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Journal articles on the topic 'Chiral Separations'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 July 2024

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1

Stalcup, A. M. "Chiral Separations." Annual Review of Analytical Chemistry 3, no. 1 (June 2010): 341–63. http://dx.doi.org/10.1146/annurev.anchem.111808.073635.

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2

Ward, Timothy J., and Daisy-Malloy Hamburg. "Chiral Separations." Analytical Chemistry 76, no. 16 (August 2004): 4635–44. http://dx.doi.org/10.1021/ac040093t.

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3

Ward, Timothy J. "Chiral Separations." Analytical Chemistry 78, no. 12 (June 2006): 3947–56. http://dx.doi.org/10.1021/ac060622o.

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4

Ward, Timothy J. "Chiral Separations." Analytical Chemistry 74, no. 12 (June 2002): 2863–72. http://dx.doi.org/10.1021/ac020240s.

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5

Ward, Timothy J. "Chiral Separations." Analytical Chemistry 72, no. 18 (September 2000): 4521–28. http://dx.doi.org/10.1021/ac000841o.

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6

Phinney, Karen W. "Chiral separations." Analytical and Bioanalytical Chemistry 372, no. 1 (December 8, 2001): 22. http://dx.doi.org/10.1007/s00216-001-1152-3.

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7

Ward, Timothy J., and Beth Ann Baker. "Chiral Separations." Analytical Chemistry 80, no. 12 (June 2008): 4363–72. http://dx.doi.org/10.1021/ac800662y.

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8

Rekoske, James E. "Chiral separations." AIChE Journal 47, no. 1 (January 2001): 2–5. http://dx.doi.org/10.1002/aic.690470102.

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9

White, Charles A., and John F. Kennedy. "Chromatographic chiral separations." Carbohydrate Polymers 10, no. 3 (January 1989): 255–56. http://dx.doi.org/10.1016/0144-8617(89)90016-7.

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10

Berkecz, Róbert, Dániel Tanács, Antal Péter, and István Ilisz. "Enantioselective Liquid Chromatographic Separations Using Macrocyclic Glycopeptide-Based Chiral Selectors." Molecules 26, no. 11 (June 3, 2021): 3380. http://dx.doi.org/10.3390/molecules26113380.

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Numerous chemical compounds of high practical importance, such as drugs, fertilizers, and food additives are being commercialized as racemic mixtures, although in most cases only one of the isomers possesses the desirable properties. As our understanding of the biological actions of chiral compounds has improved, the investigation of the pharmacological and toxicological properties has become more and more important. Chirality has become a major issue in the pharmaceutical industry; therefore, there is a continuous demand to extend the available analytical methods for enantiomeric separations and enhance their efficiency. Direct liquid chromatography methods based on the application of chiral stationary phases have become a very sophisticated field of enantiomeric separations by now. Hundreds of chiral stationary phases have been commercialized so far. Among these, macrocyclic glycopeptide-based chiral selectors have proved to be an exceptionally useful class of chiral selectors for the separation of enantiomers of biological and pharmacological importance. This review focuses on direct liquid chromatography-based enantiomer separations, applying macrocyclic glycopeptide-based chiral selectors. Special attention is paid to the characterization of the physico-chemical properties of these macrocyclic glycopeptide antibiotics providing detailed information on their applications published recently.
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11

Bai, Zheng-Wu, Fei Yang, Ke-Qin Fu, Xiao-Chen Wang, Jian-De Liu, Wei Chen, Shao-Hua Huang, and Sheng Tang. "Evaluation and comparison of N-cycloalkylformylated chitosan bis(arylcarbamate)s as chiral selectors for enantioseparation." New Journal of Chemistry 41, no. 19 (2017): 10561–67. http://dx.doi.org/10.1039/c7nj01611e.

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12

Kalíková, Květa, Martina Riesová, and Eva Tesařová. "Recentchiral selectors for separation in HPLC and CE." Open Chemistry 10, no. 3 (June 1, 2012): 450–71. http://dx.doi.org/10.2478/s11532-011-0142-3.

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AbstractEnantiomers (stereoisomers) can exhibit substantially different properties if present in chiral environments. Since chirality is a basic property of nature, the different behaviors of the individual enantiomers must be carefully studied and properly treated. Therefore, enantioselective separations are a very important part of separation science. To achieve the separation of enantiomers, an enantioselective environment must be created by the addition of a chiral selector to the separation system. Many chiral selectors have been designed and used in various fields, such as the analyses of drugs, food constituents and agrochemicals. The most popular have become the chiral selectors and/or chiral stationary phases that are of general use, i.e., are applicable in various separation systems and allow for chiral separation of structurally different compounds. This review covers the most important chiral selectors / chiral stationary phases described and applied in high performance liquid chromatography and capillary electrophoresis during the period of the last three years (2008–2011).
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13

Pinto, Madalena M. M., Carla Fernandes, and Maria E. Tiritan. "Chiral Separations in Preparative Scale: A Medicinal Chemistry Point of View." Molecules 25, no. 8 (April 21, 2020): 1931. http://dx.doi.org/10.3390/molecules25081931.

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Enantiomeric separation is a key step in the development of a new chiral drug. Preparative liquid chromatography (LC) continues to be the technique of choice either during the drug discovery process, to achieve a few milligrams, or to a scale-up during the clinical trial, needing kilograms of material. However, in the last few years, instrumental and technical developments allowed an exponential increase of preparative enantioseparation using other techniques. Besides LC, supercritical fluid chromatography (SFC) and counter-current chromatography (CCC) have aroused interest for preparative chiral separation. This overview will highlight the importance to scale-up chiral separations in Medicinal Chemistry, especially in the early stages of the pipeline of drugs discovery and development. Few examples within different methodologies will be selected, emphasizing the trends in chiral preparative separation. The advantages and drawbacks will be critically discussed.
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14

Persson, Bengt-Arne, and Shalini Andersson. "Unusual effects of separation conditions on chiral separations." Journal of Chromatography A 906, no. 1-2 (January 2001): 195–203. http://dx.doi.org/10.1016/s0021-9673(00)00949-3.

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15

Cantacuzene, D. "Chiral separations by HPLC." Biochimie 71, no. 11-12 (November 1989): 1236–37. http://dx.doi.org/10.1016/0300-9084(89)90033-3.

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16

Lämmerhofer, Michael. "Chiral separations and enantioselectivity." Journal of Chromatography A 1269 (December 2012): 1–2. http://dx.doi.org/10.1016/j.chroma.2012.10.009.

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17

Fanali, Salvatore, and Michael Lämmerhofer. "Editorial: Chromatographic Chiral Separations." Journal of Separation Science 29, no. 10 (July 2006): 1303–4. http://dx.doi.org/10.1002/jssc.200690038.

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18

Schmid, Martin G., and Gerald Gübitz. "Chiral separation by ligand-exchange." Macedonian Journal of Chemistry and Chemical Engineering 30, no. 2 (December 25, 2011): 127. http://dx.doi.org/10.20450/mjcce.2011.4.

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The principle of chiral ligand-exchange, introduced by Davankov, has become a widely used technique for chiral separation in both chromatography and in electromigration techniques. This simple technique makes use of the formation of mixed metal chelate complexes between a chiral selector and both enantiomers of an analyte. In HPLC, the chiral selector can be either bonded to the stationary phase or added to the mobile phase. In CE the chiral selector is simply added to the electrolyte. A relatively new approach represents CEC, where capillaries contain a chiral stationary phase. More than thousand papers appeared in the field of chiral ligand-exchange. To cite all papers would require several books.The present article gives an overview of both milestones and our activities on chiral separation using the principle of ligand-exchange. Recent advances in chip technology for chiral separations and new approaches regarding improvement of detection sensitivity are mentioned.
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19

Juvancz, Zoltán, Rita Bodáné-Kendrovics, Lajos Szente, and Dóra Maklári. "Cyclodextrins as Dominant Chiral Selective Agents in the Capillary Separation Techniques." Periodica Polytechnica Chemical Engineering 65, no. 4 (August 26, 2021): 580–94. http://dx.doi.org/10.3311/ppch.18067.

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This review paper shows the dominant role of the cyclodextrins in the chiral separations using capillary columns (GC, SFC, CE). The cyclodextrins (CDs) have extremely broad chiral selectivity spectra because they have several different chiral recognition sites in various arrangements and various interaction modes. Their chiral selectivity features can further improve with their various substitutions. Their selectivities are moderate therefore they need high efficiency separations (capillary columns) for good chiral resolutions. The shape selectivity of cyclodextrins is also shown with non-chiral isomers too. The utility of the cyclodextrins is demonstrated with several examples based on the personal observations of authors and critical review of literature. The theoretical backgrounds of their chiral recognitions (e.g. H-bond interaction, inclusion, induced fit) are discussed in depth. This paper is not application oriented but is dealing with mostly on the physical and chemical background of separations using CDs.
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20

Bui, Cuong Viet, Thomas Rosenau, and Hubert Hettegger. "Polysaccharide- and β-Cyclodextrin-Based Chiral Selectors for Enantiomer Resolution: Recent Developments and Applications." Molecules 26, no. 14 (July 16, 2021): 4322. http://dx.doi.org/10.3390/molecules26144322.

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Polysaccharides, oligosaccharides, and their derivatives, particularly of amylose, cellulose, chitosan, and β-cyclodextrin, are well-known chiral selectors (CSs) of chiral stationary phases (CSPs) in chromatography, because they can separate a wide range of enantiomers. Typically, such CSPs are prepared by physically coating, or chemically immobilizing the polysaccharide and β-cyclodextrin derivatives onto inert silica gel carriers as chromatographic support. Over the past few years, new chiral selectors have been introduced, and progressive methods to prepare CSPs have been exploited. Also, chiral recognition mechanisms, which play a crucial role in the investigation of chiral separations, have been better elucidated. Further insights into the broad functional performance of commercially available chiral column materials and/or the respective newly developed chiral phase materials on enantiomeric separation (ES) have been gained. This review summarizes the recent developments in CSs, CSP preparation, chiral recognition mechanisms, and enantiomeric separation methods, based on polysaccharides and β-cyclodextrins as CSs, with a focus on the years 2019–2020 of this rapidly developing field.
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21

Papp, Lajos Attila, Zoltán István Szabó, Gabriel Hancu, Lénárd Farczádi, and Eleonora Mircia. "Comprehensive Review on Chiral Stationary Phases in Single-Column Simultaneous Chiral–Achiral HPLC Separation Methods." Molecules 29, no. 6 (March 18, 2024): 1346. http://dx.doi.org/10.3390/molecules29061346.

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This comprehensive review explores the utilization of chiral stationary phases (CSPs) in the context of single-column simultaneous chiral–achiral high-performance liquid chromatography (HPLC) separation methods. While CSPs have traditionally been pivotal for enantioselective drug analysis, contemporary CSPs often exhibit notable chemoselective properties. Consequently, there is a discernible trend towards the development of methodologies that enable simultaneous enantio- and chemoselective separations utilizing a single CSP-based chromatographic column. This review provides an exhaustive overview of reported HPLC methods in this domain, with a focus on four major CSP types: cyclodextrin-, glycopeptide antibiotic-, protein-, and polysaccharide-based CSPs. This article delves into the diverse applications of CSPs, encompassing various chromatographic modes such as normal phase (NP), reverse phase (RP), and polar organic (PO). This review critically discusses method development, emphasizing the additional chemoselective separation mechanisms of CSPs. It also explores possibilities for method optimization and development, concluding with future perspectives on this evolving field. Despite the inherent challenges in understanding the retention mechanisms involved in chemoselective separations, this review highlights promising trends and anticipates a growing number of simultaneous enantio- and chemoselective methods in pharmaceutical analyses, pharmacokinetic studies, and environmental sample determinations.
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22

Lin, Wenbin. "Metal-Organic Frameworks for Asymmetric Catalysis and Chiral Separations." MRS Bulletin 32, no. 7 (July 2007): 544–48. http://dx.doi.org/10.1557/mrs2007.104.

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Metal-organic frameworks (MOFs) are an interesting class of molecule-based hybrid materials built from metal-connecting points and bridging ligands. MOFs have received much attention, owing to their potential impact on many technological areas, including gas storage, separation, and heterogeneous catalysis. The modular nature of MOFs endows them with facile tunability, and as a result, properly designed MOFs can yield ideal heterogeneous catalysts with uniform active sites through judicious choice of the building blocks. Homochiral MOFs, which can be prepared by numerous approaches (construction from achiral components by seeding with a chiral single crystal, templating with coordinating chiral co-ligands, and building from metal-connecting nodes and chiral bridging ligands), represent a unique class of materials for the economical production of optically pure compounds, whether through asymmetric catalysis or enantioselective inclusion of chiral guest molecules in their porous frameworks. As such, homochiral MOFs promise new opportunities for developing chirotechnology. This contribution provides a brief overview of recent progress in the synthesis of homochiral porous MOFs and their applications in asymmetric catalysis and chiral separations.
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23

Zhao, Yuan, Xuecheng Zhu, Wei Jiang, Huilin Liu, and Baoguo Sun. "Chiral Recognition for Chromatography and Membrane-Based Separations: Recent Developments and Future Prospects." Molecules 26, no. 4 (February 21, 2021): 1145. http://dx.doi.org/10.3390/molecules26041145.

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With the rapid development of global industry and increasingly frequent product circulation, the separation and detection of chiral drugs/pesticides are becoming increasingly important. The chiral nature of substances can result in harm to the human body, and the selective endocrine-disrupting effect of drug enantiomers is caused by differential enantiospecific binding to receptors. This review is devoted to the specific recognition and resolution of chiral molecules by chromatography and membrane-based enantioseparation techniques. Chromatographic enantiomer separations with chiral stationary phase (CSP)-based columns and membrane-based enantiomer filtration are detailed. In addition, the unique properties of these chiral resolution methods have been summarized for practical applications in the chemistry, environment, biology, medicine, and food industries. We further discussed the recognition mechanism in analytical enantioseparations and analyzed recent developments and future prospects of chromatographic and membrane-based enantioseparations.
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24

D'Hulst, Annick, and Norbert Verbeke. "Separation of the enantiomers of coumarinic anticoagulant drugs by capillary electrophoresis using maltodextrins as chiral modifiers." Chirality 6, no. 4 (January 1994): 225–29. http://dx.doi.org/10.1002/chir.530060403.

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AbstractThe separation and quantitation of coumarinic anticoagulant drug enantiomers were achieved by direct chiral capillary electrophoresis using complex maltooligosaccharide mixtures as stereoselective electrolyte modifiers. Chiral separations were characterized by a high selectivity and efficiency, enabling enantiomeric excess determinations. In addition, preliminary results indicate the applicability of the method for the determination of individual enantiomers in biological samples. So the method can be used to perform stereoselective pharmacokinetic studies. © 1994 Wiley‐Liss, Inc.
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25

Ward, Timothy J., and Karen D. Ward. "Chiral Separations: Fundamental Review 2010." Analytical Chemistry 82, no. 12 (June 15, 2010): 4712–22. http://dx.doi.org/10.1021/ac1010926.

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26

BORMAN, STU. "Apoenzyme membranes achieve chiral separations." Chemical & Engineering News 75, no. 34 (August 25, 1997): 10–11. http://dx.doi.org/10.1021/cen-v075n034.p010a.

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27

Rocco, Anna, Zeineb Aturki, and Salvatore Fanali. "Chiral separations in food analysis." TrAC Trends in Analytical Chemistry 52 (December 2013): 206–25. http://dx.doi.org/10.1016/j.trac.2013.05.022.

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28

D'Orazio, Giovanni, Chiara Fanali, María Asensio-Ramos, and Salvatore Fanali. "Chiral separations in food analysis." TrAC Trends in Analytical Chemistry 96 (November 2017): 151–71. http://dx.doi.org/10.1016/j.trac.2017.05.013.

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29

Vespalec, Radim, and Petr Boček. "Chiral Separations in Capillary Electrophoresis." Chemical Reviews 100, no. 10 (October 2000): 3715–54. http://dx.doi.org/10.1021/cr9411583.

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30

JACOBY, MITCH. "FAST SEPARATIONS FOR CHIRAL DRUGS." Chemical & Engineering News 79, no. 21 (May 21, 2001): 68–69. http://dx.doi.org/10.1021/cen-v079n021.p068.

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31

Schurig, Volker. "Chiral separations using gas chromatography." TrAC Trends in Analytical Chemistry 21, no. 9-10 (September 2002): 647–61. http://dx.doi.org/10.1016/s0165-9936(02)00808-7.

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32

Barry, Eugene F. "Chiral separations by liquid chromatography." Microchemical Journal 45, no. 2 (April 1992): 249–50. http://dx.doi.org/10.1016/0026-265x(92)90016-v.

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33

Belder, Detlev, and Martin Ludwig. "Microchip electrophoresis for chiral separations." ELECTROPHORESIS 24, no. 15 (August 2003): 2422–30. http://dx.doi.org/10.1002/elps.200305497.

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34

Vespalec, Radim, and Petr Boček. "Chiral separations in capillary electrophoresis." Electrophoresis 20, no. 13 (September 1, 1999): 2579–91. http://dx.doi.org/10.1002/(sici)1522-2683(19990901)20:13<2579::aid-elps2579>3.0.co;2-r.

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35

Turner, D. R. "Engineering chiral frameworks for separations." Acta Crystallographica Section A Foundations and Advances 79, a2 (August 22, 2023): C184. http://dx.doi.org/10.1107/s2053273323094251.

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36

Yu, Raymond B., and Joselito P. Quirino. "Chiral Selectors in Capillary Electrophoresis: Trends During 2017–2018." Molecules 24, no. 6 (March 21, 2019): 1135. http://dx.doi.org/10.3390/molecules24061135.

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Chiral separation is an important process in the chemical and pharmaceutical industries. From the analytical chemistry perspective, chiral separation is required for assessing the fit-for-purpose and the safety of chemical products. Capillary electrophoresis, in the electrokinetic chromatography mode is an established analytical technique for chiral separations. A water-soluble chiral selector is typically used. This review therefore examines the use of various chiral selectors in electrokinetic chromatography during 2017–2018. The chiral selectors were both low and high (macromolecules) molecular mass molecules as well as molecular aggregates (supramolecules). There were 58 papers found by search in Scopus, indicating continuous and active activity in this research area. The macromolecules were sugar-, amino acid-, and nucleic acid-based polymers. The supramolecules were bile salt micelles. The low molecular mass selectors were mainly ionic liquids and complexes with a central ion. A majority of the papers were on the use or preparation of sugar-based macromolecules, e.g., native or derivatised cyclodextrins. Studies to explain chiral recognition of macromolecular and supramolecular chiral selectors were mainly done by molecular modelling and nuclear magnetic resonance spectroscopy. Demonstrations were predominantly on drug analysis for the separation of racemates.
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37

Juvancz, Zoltán, Rita Bodáné-Kendrovics, Zita Laczkó, Róbert Iványi, and Erzsébet Varga. "Chiral Separations of Pyrethroic Acids Using Cyclodextrin Selectors." Molecules 27, no. 24 (December 9, 2022): 8718. http://dx.doi.org/10.3390/molecules27248718.

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Pyrethroid insecticides are broadly used. They have low toxicity for warm-blooded living creatures, but high toxicity for both insects and fish. Therefore, it is important to reduce the environmental impact of pyrethroids. Pyrethroic acids are chiral compounds. An effective way to decrease pollution is to use enantio-pure insecticide products instead of their racemic mixtures. Enantiomer-pure products require enantiomer selective synthesis and analysis. The chiral selective analysis of pyrethroic acids (an intermediate of pyrethroids) is also important in terms of process control and from the point of view of their degradation metabolism in the environment. This study used various enantiomeric selective chromatographic methods for the separation of different pyrethroic acids, including gas chromatography, supercritical fluid chromatography and capillary electrophoresis. Systematic experiments were conducted to find the optimum conditions for their chiral separation. The employed enantio-selective agents were cyclodextrin derivatives with different ring sizes and substitution patterns. The β-cyclodextrin proved to be excellent for the chiral separation of these acids. The different chiral recognition mechanisms were established using different ring-sized cyclodextrins. The results of these systematic studies demonstrated the correlations of the chiral selectivity features of selectors and the structures of analytes.
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38

Zhou, Jie, Bo Yang, Jian Tang, and Weihua Tang. "A cationic cyclodextrin clicked bilayer chiral stationary phase for versatile chiral separation in HPLC." New Journal of Chemistry 42, no. 5 (2018): 3526–33. http://dx.doi.org/10.1039/c7nj04960a.

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39

Rizzi, Andreas M., and Christina Plank. "Coupled column chromatography in chiral separations: systems employing β-eyclodextrin phases for chiral separation." Journal of Chromatography A 557 (September 1991): 199–213. http://dx.doi.org/10.1016/s0021-9673(01)87133-8.

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40

Lu, Tingting, Wenfu Yan, and Ruren Xu. "Chiral zeolite beta: structure, synthesis, and application." Inorganic Chemistry Frontiers 6, no. 8 (2019): 1938–51. http://dx.doi.org/10.1039/c9qi00574a.

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41

Ismail, Omar, Simona Felletti, Chiara Luca, Luisa Pasti, Nicola Marchetti, Valentina Costa, Francesco Gasparrini, Alberto Cavazzini, and Martina Catani. "The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid Chromatography." Molecules 23, no. 10 (October 20, 2018): 2709. http://dx.doi.org/10.3390/molecules23102709.

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Until less than 10 years ago, chiral separations were carried out with columns packed with 5 or 3 μ m fully porous particles (FPPs). Times to resolve enantiomeric mixtures were easily larger than 30 min, or so. Pushed especially by stringent requirements from medicinal and pharmaceutical industries, during the last years the field of chiral separations by liquid chromatography has undergone what can be defined a “true revolution”. With the purpose of developing ever faster and efficient method of separations, indeed, very efficient particle formats, such as superficially porous particles (SPPs) or
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42

Duan, Xinzhe. "Advancement of Chiral Resolution and Separations: Techniques and Applications." Highlights in Science, Engineering and Technology 83 (February 27, 2024): 305–10. http://dx.doi.org/10.54097/h64b4b49.

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Chirality, a ubiquitous phenomenon in nature, denotes the incapability of an entity to superimpose onto its mirror image. This property is inherently manifested in biological systems, where critical biomolecules such as DNA, enzymes, and proteins exist as chiral substances. Notably, proteins often demonstrate enantioselectivity towards their interacting partners, underscoring the critical role of chirality in drug-protein interactions. Consequently, the chirality of pharmaceutical agents significantly influences their efficacy and interaction with targeted proteins, necessitating a profound understanding and ability in chiral separation science to address challenges about chiral drug availability. Despite the complexity of enantiomer separation, the past few decades have witnessed substantial advancements in chiral resolution techniques. This article elucidates several pivotal methods: crystallization-based techniques, chromatographic separation, kinetic resolution, membrane-based separation, etc. Furthermore, the author spotlighted the application of chiral resolution methodologies at various drug research and development junctures, exemplified by a detailed case study on Sotorasib. This discourse aims to accentuate the burgeoning significance and the strides achieved in chiral resolution, paving the way for future innovative developments in this vital scientific domain.
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43

Kalíková, Květa, Denisa Folprechtová, and Zuzana Kadlecová. "Sub/supercritical Fluid Chromatography for Chiral Compounds Analysis." Chemické listy 116, no. 3 (March 15, 2022): 146–51. http://dx.doi.org/10.54779/chl20220146.

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Chirality is an essential feature of nature as it is common for many biologically active compounds. The different biological effects of individual enantiomers in a chiral environment are generally known. Therefore, there is a need for fast, efficient, and robust methods for their separation, quantification, and purification, too. The easiest way is to use chromatographic methods utilizing chiral stationary phases. Sub/supercritical fluid chromatography has become popular in the field of enantioselective separations in various scopes and, in some cases, has become a method of the first choice. Therefore, this review article covers actual trends and possibilities of sub/supercritical fluid chromatography in enantioseparations. Ways to influence enantioselectivity of the separation system by column coupling, screening approaches, and processes of methodical development for fast and efficient analyses are discussed. Sub/supercritical fluid chromatography under suitable experimental conditions provides fast and highly efficient separation of chiral compounds.
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44

Gong, Ya-Nan, Qi-Yu Ma, Ying Wang, Jun-Hui Zhang, You-Ping Zhang, Rui-Xue Liang, Bang-Jin Wang, Sheng-Ming Xie, and Li-Ming Yuan. "Preparation of Chiral Porous Organic Cage Clicked Chiral Stationary Phase for HPLC Enantioseparation." Molecules 28, no. 7 (April 4, 2023): 3235. http://dx.doi.org/10.3390/molecules28073235.

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Porous organic cages (POCs) are a new subclass of porous materials, which are constructed from discrete cage molecules with permanent cavities via weak intermolecular forces. In this study, a novel chiral stationary phase (CSP) has been prepared by chemically binding a [4 + 6]-type chiral POC (C120H96N12O4) with thiol-functionalized silica gel using a thiol-ene click reaction and applied to HPLC separations. The column packed with this CSP presented good separation capability for chiral compounds and positional isomers. Thirteen racemates have been enantioseparated on this column, including alcohols, diols, ketones, amines, epoxides, and organic acids. Upon comparison with a previously reported chiral POC NC1-R-based column, commercial Chiralpak AD-H, and Chiralcel OD-H columns, this column is complementary to these three columns in terms of its enantiomeric separation; and can also separate some racemic compounds that cannot be separated by the three columns. In addition, eight positional isomers (iodoaniline, bromoaniline, chloroaniline, dibromobenzene, dichlorobenzene, toluidine, nitrobromobenzene, and nitroaniline) have also been separated. The influences of the injection weight and column temperature on separation have been explored. After the column has undergone multiple injections, the relative standard deviations (RSDs) for the retention time and selectivity were below 1.0 and 1.5%, respectively, indicating the good reproducibility and stability of the column for separation. This work demonstrates that POCs are promising materials for HPLC separation.
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45

Basheer, Al Arsh, Iqbal Hussain, Marcus T. Scotti, Luciana Scotti, and Imran Ali. "Advances in Chiral Separations at Nano Level." Current Analytical Chemistry 16, no. 4 (June 1, 2020): 351–68. http://dx.doi.org/10.2174/1573407215666190131122413.

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Background:: Nano level chiral separation is necessary and demanding in the development of the drug, genomic, proteomic, and other chemical and the environmental sciences. Few drugs exist in human body cells for some days at nano level concentrations, that are out of the jurisdiction of the detection by standard separation techniques. Likewise, the separation and identification of xenobiotics and other environmental contaminants (at nano or low levels) are necessary for our healthiness. Discussion: Conclusion: This article will be beneficial for chiral chromatographers, academicians, pharmaceutical industries, environmental researchers and Government regulation authorities.
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Ferraro, John M., and Weston J. Umstead. "Chiral Separation of Cannabichromene, Cannabicyclol, and Their Acidic Analogs on Polysaccharide Chiral Stationary Phases." Molecules 28, no. 3 (January 24, 2023): 1164. http://dx.doi.org/10.3390/molecules28031164.

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Until recently, chirality has not been a major focus in the study of cannabinoids, as most cannabinoids of interest, such as cannabidiol and tetrahydrocannabinol, exist as a single isomer from natural sources. However, this is changing as more cannabinoids are identified, and compounds such as cannabichromene and cannabicyclol are emerging as potential investigatory candidates for varying indications. Because these molecules are chiral, the separation and study of the individual enantiomers’ biological and physiological effects should therefore be of interest. The purpose of this study was to identify analytical separation conditions and then adapt those conditions to preparative separation. This was accomplished with a column-screening approach on Daicel’s immobilized polysaccharide chiral stationary phases using non-traditional mobile phases, which included dichloromethane, ethyl acetate, and methyl tert-butyl ether under high-performance liquid chromatography conditions. CHIRALPAK® IK was found to separate all four compounds well with mobile phases containing hexane-dichloromethane (with or without an acidic additive). From these methods, the separation productivities were calculated to better visualize the separation scalability, which shows that the kilogram-scale separations of each are feasible.
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Licea-Perez, Hermes, and Christopher A. Evans. "New insights into supercritical fluid chromatography for chiral separations." Analytical Methods 9, no. 17 (2017): 2603–10. http://dx.doi.org/10.1039/c7ay00452d.

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Supercritical fluid chromatography in combination with chiral stationary phases has proven to be a great tool for chiral resolution, alleviating some of the challenges associated with bioanalysis of stereoisomers.
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Dowling, Victoria A., Joseph A. M. Charles, Emily Nwakpuda, and Linda B. McGown. "A Reversible Gel for Chiral Separations." Analytical Chemistry 76, no. 15 (August 2004): 4558–63. http://dx.doi.org/10.1021/ac0400010.

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Wang, Fang, and Morteza G. Khaledi. "Chiral Separations by Nonaqueous Capillary Electrophoresis." Analytical Chemistry 68, no. 19 (January 1996): 3460–67. http://dx.doi.org/10.1021/ac960537o.

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Schwarz, Maria A., and Peter C. Hauser. "Chiral On-Chip Separations of Neurotransmitters." Analytical Chemistry 75, no. 17 (September 2003): 4691–95. http://dx.doi.org/10.1021/ac030148b.

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