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Relevant bibliographies by topics / Chiral xenobiotics

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Academic literature on the topic 'Chiral xenobiotics'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Chiral xenobiotics"

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Madhukar., A1 Swathi. E1* S. Pranathi1 Vineela Devi1 K. Surender Reddy2. "Analysis of Xenobiotics: A Review." Journal of Pharma Research 1, no. 1 (2012): 5–11. https://doi.org/10.5281/zenodo.1098647.

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<strong><em>ABSTRACT</em></strong> <em>A xenobiotic is a </em><em>chemical which is found in an organism but which is not normally produced or expected to be present in it. It can also cover substances which are present in much higher concentrations than are usual. This study deals with the analysis of xenobiotics in detail including the concepts like Xenobiotic Metabolism(Xenobiotic Biotransformation), Rapid analysis of pharmaceuticals and excreted xenobiotic and endogenous metabolites with atmospheric pressure infrared MALDI mass spectrometry , De

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2

Basheer, Al Arsh, Iqbal Hussain, Marcus T. Scotti, Luciana Scotti, and Imran Ali. "Advances in Chiral Separations at Nano Level." Current Analytical Chemistry 16, no. 4 (2020): 351–68. http://dx.doi.org/10.2174/1573407215666190131122413.

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Background:: Nano level chiral separation is necessary and demanding in the development of the drug, genomic, proteomic, and other chemical and the environmental sciences. Few drugs exist in human body cells for some days at nano level concentrations, that are out of the jurisdiction of the detection by standard separation techniques. Likewise, the separation and identification of xenobiotics and other environmental contaminants (at nano or low levels) are necessary for our healthiness. Discussion: Conclusion: This article will be beneficial for chiral chromatographers, academicians, pharmaceu

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3

Schmidt, W. F., and George Gassner. "Chirality and Computational Chemistry: A New Direction." Current Medicinal Chemistry 1, no. 6 (1995): 502–10. http://dx.doi.org/10.2174/092986730106220216115714.

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Abstract: Physical and biological responses to natural and synthetic chemicals occur only at molecular distances and at molecular dimensions. Computational chemistry calculates results in molecular dimensions, but has serious difficulties in accurately predicting chiral interactions between diastereoisomers and/or enantiomers. Prediction of structures and conformations for more complicated chiral interactions such as in protein folding and protein binding may be intrinsically inaccurate because the molecular consequences of the forces between these spatially close chiral centers are not explic

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4

Mohamed, Hawsar Othman, Attila Almási, and Pal Perjesi. "Effect of experimental hyperglycemia on intestinal elimination and biliary excretion of ibuprofen enantiomers in hyperglycemic rats." Journal of Pharmaceutical and Biopharmaceutical Research 4, no. 2 (2022): 283–95. http://dx.doi.org/10.25082/jpbr.2022.02.001.

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Diabetic complications are mostly due to hyperglycemia. Hyperglycemia is reported to be associated with oxidative stress. It can result in changes in the activities of drug-metabolizing enzymes and membrane-integrated transporters, which can modify the fate of drugs and other xenobiotics. An in vivo intestinal perfusion model was used to investigate how experimental hyperglycemia affects intestinal elimination and biliary excretion of ibuprofen enantiomers in the rat. Experimental diabetes was induced by intravenous (i.v.) administration of streptozotocin. The intestinal perfusion medium conta

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5

Hühnerfuss, Heinrich. "Chromatographic enantiomer separation of chiral xenobiotics and their metabolites – A versatile tool for process studies in marine and terrestrial ecosystems." Chemosphere 40, no. 9-11 (2000): 913–19. http://dx.doi.org/10.1016/s0045-6535(99)00333-1.

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6

Testa, Bernard. "Mechanisms of chiral recognition in xenobiotic metabolism and drug-receptor interactions." Chirality 1, no. 1 (1989): 7–9. http://dx.doi.org/10.1002/chir.530010104.

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7

Aline, Telzerow, Paris Juraj, Håkansson Maria, et al. "Amine Transaminase from Exophiala Xenobiotica – Crystal Structure and Engineering of a Fold IV Transaminase that Naturally Converts Biaryl Ketones." ACS Catalysis 9, no. 2 (2018): 1140–48. https://doi.org/10.5281/zenodo.3233728.

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ABSTRACT: Amine transaminases are frequently used for the production of chiral amines starting from prochiral ketones. These amines can be applied as active pharmaceutical ingredients or drug precursors. However, there are still limitations to the use of amine transaminases when it comes to bulky ketone substrates, such as biaryl ketones. Using data mining, an (<em>R</em>)-selective amine transaminase from <em>Exophiala xenobiotica</em> was identified which naturally converts biaryl ketone substrates to the corresponding amines with up to 85% conversion and excellent enantioselectivity (>99

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8

Wang, L., and S. J. Khan. "Enantioselective analysis and fate of polycyclic musks in a water recycling plant in Sydney (Australia)." Water Science and Technology 69, no. 10 (2014): 1996–2003. http://dx.doi.org/10.2166/wst.2014.095.

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Synthetic polycyclic musks (PCMs) Galaxolide (HHCB), Tonalide (AHTN), Phantolide (AHDI), Traseolide (ATII) and Cashmeran (DPMI) are chiral chemicals that are commonly used in washing product industries as racemic mixtures. The major source of PCMs in municipal wastewater is from personal care and household products. Recent studies have shown that PCMs may enhance the relative toxicity of other environmental chemicals by inhibiting cellular xenobiotic defence systems. High sensitivity enantioselective analysis of these compounds enables improved characterisation of the environmental persistence

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9

Peters, Christin, Florian Rudroff, Marko D. Mihovilovic, and Uwe T. Bornscheuer. "Fusion proteins of an enoate reductase and a Baeyer-Villiger monooxygenase facilitate the synthesis of chiral lactones." Biological Chemistry 398, no. 1 (2017): 31–37. http://dx.doi.org/10.1515/hsz-2016-0150.

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Abstract Nature uses the advantages of fusion proteins for multi-step reactions to facilitate the metabolism in cells as the conversion of substrates through intermediates to the final product can take place more rapidly and with less side-product formation. In a similar fashion, also for enzyme cascade reactions, the fusion of biocatalysts involved can be advantageous. In the present study, we investigated fusion of an alcohol dehydrogenase (ADH), an enoate reductase (ERED) and a Baeyer-Villiger monooxygenase (BVMO) to enable the synthesis of (chiral) lactones starting from unsaturated alcoho

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Kageyama, Yu-Ichi, Yoshimitsu Yamazaki, Adel S. Afify, Yoshikatsu Ogawa, Tomoko Okada, and Hiroaki Okuno. "Stereoselective hydrolysis of xenobiotic esters by different cell lines from rat liver and hepatoma and its application to chiral prodrugs for designated growth suppression of cancer cells." Chirality 7, no. 4 (1995): 297–304. http://dx.doi.org/10.1002/chir.530070418.

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Books on the topic "Chiral xenobiotics"

1

1944-, Hühnerfuss H., ed. Chiral environmental pollutants: Trace analysis and ecotoxicology. Springer, 2001.

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2

Kallenborn, R., and H. Hühnerfuss. Chiral Environmental Pollutants. Springer, 2001.

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Book chapters on the topic "Chiral xenobiotics"

1

Kallenborn, Roland, and Heinrich Hühnerfuss. "Chiral Xenobiotics in the Environment." In Chiral Environmental Pollutants. Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-662-06243-2_3.

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2

Rostron, Chris. "Drug Synthesis." In Drug Design and Development. Oxford University Press, 2020. http://dx.doi.org/10.1093/hesc/9780198749318.003.0009.

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This chapter assesses drug synthesis, which has become an integral component, not only of drug development, but also of drug design. Key to any synthetic method is the nature of the starting materials. Wherever possible, a balance must be achieved between the availability and cost of starting materials and the relative probability of them giving rise to the required final product. In addition to the starting materials, the nature of the chemical reactions involved in the synthetic pathway need to be taken into consideration. The chapter examines the design of drug synthetic pathways, diversity

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