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Journal articles on the topic 'Chitosan nerve guide'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Stenberg, Lena, Maria Stößel, Giulia Ronchi, et al. "Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides." BMC Neuroscience 18, no. 1 (2017): 53. https://doi.org/10.1186/s12868-017-0374-z.

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<strong>Background: </strong>Delayed reconstruction of transection or laceration injuries of peripheral nerves is inflicted by a reduced regeneration capacity. Diabetic conditions, more frequently encountered in clinical practice, are known to further impair regeneration in peripheral nerves. Chitosan nerve guides (CNGs) have recently been introduced as a new generation of medical devices for immediate peripheral nerve reconstruction. Here, CNGs were used for 45 days delayed reconstruction of critical length 15 mm rat sciatic nerve defects in either healthy Wistar rats or diabetic Goto-Kakizak

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2

Lin, Chuang Yu, Li Tzu Li, and Wen Ta Su. "Cell Cycle Analysis of Rat Schwann Cells on Chitosan Scaffolds by Flow Cytometry." Applied Mechanics and Materials 284-287 (January 2013): 46–50. http://dx.doi.org/10.4028/www.scientific.net/amm.284-287.46.

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The fine combination of biomaterial and essential cells determines a successful artificial graft. With high biocompatibility, chitosan is a choice of materials for regeneration medicine. In the peripheral nervous system, Schwann cells are critical for nerve regeneration. Schwann cells not only help to conduct the nerve pulse but also guide the nerve extension, especially the injured nerve for recovery. Studies showed that chitosan can be a bridge material for damaged nerve regeneration. The interactions between chitosan and Schwann cells may provide important information for designing the chit

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Stößel, Maria, Jennifer Metzen, Vivien M. Wildhagen, et al. "Long-Term In Vivo Evaluation of Chitosan Nerve Guide Properties with respect to Two Different Sterilization Methods." BioMed Research International 2018 (June 4, 2018): 1–11. http://dx.doi.org/10.1155/2018/6982738.

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Severe peripheral nerve injuries are reconstructed either with autologous nerve grafts (gold standard) or alternatively with clinically approved artificial nerve guides. The most common method used to sterilize these medical products is ethylene oxide gassing (EO). However, this method has several disadvantages. An alternative, which has been barely studied so far, represents beta irradiation (β). In previous studies, we developed an artificial nerve guide made of chitosan (chitosan nerve guide, CNG), a biomaterial that is known to potentially retain toxic residues upon EO sterilization. There

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Huang, Zhong, Svenja Kankowski, Ella Ertekin, et al. "Modified Hyaluronic Acid-Laminin-Hydrogel as Luminal Filler for Clinically Approved Hollow Nerve Guides in a Rat Critical Defect Size Model." International Journal of Molecular Sciences 22, no. 12 (2021): 6554. http://dx.doi.org/10.3390/ijms22126554.

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Hollow nerve guidance conduits are approved for clinical use for defect lengths of up to 3 cm. This is because also in pre-clinical evaluation they are less effective in the support of nerve regeneration over critical defect lengths. Hydrogel luminal fillers are thought to improve the regeneration outcome by providing an optimized matrix inside bioartificial nerve grafts. We evaluated here a modified hyaluronic acid-laminin-hydrogel (M-HAL) as luminal filler for two clinically approved hollow nerve guides. Collagen-based and chitosan-based nerve guides were filled with M-HAL in two different c

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Gomes, J., Jorge R.M. Natal, and J. Belinha. "An elastoplastic constitutive model to simulate the non-linear behaviour of chitosan material for nerve regeneration guide tubes applications." Journal of Computation and Artificial Intelligence in Mechanics and Biomechanics 2, no. 2 (2022): 97–110. https://doi.org/10.5281/zenodo.7492983.

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Neurotmesis is the most severe injury a peripheral nerve can endure. One of the strategies to treat this type of nerve injury is the tubulization technique, consisting of bridging the two nerve tips enclosed by a tube made of a compatible biomaterial. Chitosan scaffolds is one of the most popular (and successful) solutions used for the tubulization technique. After implanting the chitosan tube, it will experience mechanical stimuli due to natural movements, inducing strain-stress states in the biomaterial. It is relevant to characterize the mechanical behaviour of chitosan scaffolds in order t

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Sierakowska-Byczek, Aleksandra, Julia Radwan-Pragłowska, Łukasz Janus, et al. "Environment-Friendly Preparation and Characterization of Multilayered Conductive PVP/Col/CS Composite Doped with Nanoparticles as Potential Nerve Guide Conduits." Polymers 16, no. 7 (2024): 875. http://dx.doi.org/10.3390/polym16070875.

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Tissue engineering constitutes the most promising method of severe peripheral nerve injuries treatment and is considered as an alternative to autografts. To provide appropriate conditions during recovery special biomaterials called nerve guide conduits are required. An ideal candidate for this purpose should not only be biocompatible and protect newly forming tissue but also promote the recovery process. In this article a novel, multilayered biomaterial based on polyvinylpyrrolidone, collagen and chitosan of gradient structure modified with conductive nanoparticles is presented. Products were

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Li, Xiaoxia, Wei Wang, Guoqiang Wei, Guanxiong Wang, Weiguo Zhang, and Xiaojun Ma. "Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration." Biotechnology Letters 32, no. 9 (2010): 1333–37. http://dx.doi.org/10.1007/s10529-010-0287-8.

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8

Alvites, Rui D., Mariana V. Branquinho, Ana C. Sousa, et al. "Combined Use of Chitosan and Olfactory Mucosa Mesenchymal Stem/Stromal Cells to Promote Peripheral Nerve Regeneration In Vivo." Stem Cells International 2021 (January 2, 2021): 1–32. http://dx.doi.org/10.1155/2021/6613029.

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Peripheral nerve injury remains a clinical challenge with severe physiological and functional consequences. Despite the existence of multiple possible therapeutic approaches, until now, there is no consensus regarding the advantages of each option or the best methodology in promoting nerve regeneration. Regenerative medicine is a promise to overcome this medical limitation, and in this work, chitosan nerve guide conduits and olfactory mucosa mesenchymal stem/stromal cells were applied in different therapeutic combinations to promote regeneration in sciatic nerves after neurotmesis injury. Over

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9

Cárdenas-Triviño, Galo, and Rodrigo Soto-Seguel. "CHITOSAN COMPOSITES PREPARATION AND CHARACTERIZATION OF GUIDE TUBES FOR NERVE REPAIR." Journal of the Chilean Chemical Society 65, no. 3 (2020): 4870–78. http://dx.doi.org/10.4067/s0717-97072020000204870.

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10

Russo, Teresa, Stefania Scialla, Marietta D’Albore, Iriczalli Cruz-Maya, Roberto De Santis, and Vincenzo Guarino. "An Easy-to-Handle Route for Bicomponent Porous Tubes Fabrication as Nerve Guide Conduits." Polymers 16, no. 20 (2024): 2893. http://dx.doi.org/10.3390/polym16202893.

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Over the past two decades, the development of nerve guide conduits (NGCs) has gained much attention due to the impellent need to find innovative strategies to take care of damaged or degenerated peripheral nerves in clinical surgery. In this view, significant effort has been spent on the development of high-performance NGCs by different materials and manufacturing approaches. Herein, a highly versatile and easy-to-handle route to process 3D porous tubes made of chitosan and gelatin to be used as a nerve guide conduit were investigated. This allowed us to fabricate highly porous substrates with

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Biazar, Esmaeil, and Saeed Heidari Keshel. "Chitosan–Cross-Linked Nanofibrous PHBV Nerve Guide for Rat Sciatic Nerve Regeneration Across a Defect Bridge." ASAIO Journal 59, no. 6 (2013): 651–59. http://dx.doi.org/10.1097/mat.0b013e3182a79151.

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Biazar, Esmaeil, and Saeed Heidari Keshel. "Development of chitosan-crosslinked nanofibrous PHBV guide for repair of nerve defects." Artificial Cells, Nanomedicine, and Biotechnology 42, no. 6 (2013): 385–91. http://dx.doi.org/10.3109/21691401.2013.832686.

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13

Yan, Xiumei, Yi Yu, Shaobing Wang, et al. "Preparation and characterization of conductive nerve guide conduit filled with dual drug-loaded nanofibers." Journal of Bioactive and Compatible Polymers 36, no. 6 (2021): 531–47. http://dx.doi.org/10.1177/08839115211053917.

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Peripheral nerve injury (PNI) has become one of the common clinical diseases. How to promote the regeneration and function recovery of the damaged peripheral nerve has been the focus of attention in the medical field. Evidence suggests that the longitudinal filling of oriented fibers in nerve guide conduit (NGC) is especially beneficial to the repair of long gap PNI. In this study, polypyrrole (PPy) nanospheres (PNSs) were prepared by the soft-templating method, and mixed with poly (lactic acid) (PLA) to prepare conductive PNSs/PLA NGC, and the optimal ratio of PNSs was 4.5%. PLA and vascular

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Sorkin, Jonathan A., Ziv Rechany, Mara Almog, et al. "A Rabbit Model for Peripheral Nerve Reconstruction Studies Avoiding Automutilation Behavior." Journal of Brachial Plexus and Peripheral Nerve Injury 17, no. 01 (2022): e22-e29. http://dx.doi.org/10.1055/s-0042-1747959.

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Abstract Background The rabbit sciatic nerve injury model may represent a valuable alternative for critical gap distance seen in humans but often leads to automutilation. In this study, we modified the complete sciatic nerve injury model for avoiding autophagy. Materials and Methods In 20 adult female New Zealand White rabbits, instead of transecting the complete sciatic nerve, we unilaterally transected the tibial portion and preserved the peroneal portion. Thereby loss of sensation in the dorsal aspect of the paw was avoided. The tibial portion was repaired in a reversed autograft approach i

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Fornasari, Benedetta E., Marwa El Soury, Giulia Nato, et al. "Fibroblasts Colonizing Nerve Conduits Express High Levels of Soluble Neuregulin1, a Factor Promoting Schwann Cell Dedifferentiation." Cells 9, no. 6 (2020): 1366. http://dx.doi.org/10.3390/cells9061366.

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Conduits for the repair of peripheral nerve gaps are a good alternative to autografts as they provide a protected environment and a physical guide for axonal re-growth. Conduits require colonization by cells involved in nerve regeneration (Schwann cells, fibroblasts, endothelial cells, macrophages) while in the autograft many cells are resident and just need to be activated. Since it is known that soluble Neuregulin1 (sNRG1) is released after injury and plays an important role activating Schwann cell dedifferentiation, its expression level was investigated in early regeneration steps (7, 14, 2

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Xie, Feng, Qing Feng Li, Bin Gu, Kai Liu, and Guo Xiong Shen. "In vitro and in vivo evaluation of a biodegradable chitosan-PLA composite peripheral nerve guide conduit material." Microsurgery 28, no. 6 (2008): 471–79. http://dx.doi.org/10.1002/micr.20514.

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Nie, Xin, Manjing Deng, Maojin Yang, Luchuan Liu, Yongjie Zhang та Xiujie Wen. "Axonal Regeneration and Remyelination Evaluation of Chitosan/Gelatin-Based Nerve Guide Combined with Transforming Growth Factor-β1 and Schwann Cells". Cell Biochemistry and Biophysics 68, № 1 (2013): 163–72. http://dx.doi.org/10.1007/s12013-013-9683-8.

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Simões, M. J., A. Gärtner, Y. Shirosaki, et al. "In vitro and in vivo chitosan membranes testing for peripheral nerve reconstruction." Acta Médica Portuguesa 24, no. 1 (2011): 43. http://dx.doi.org/10.20344/amp.344.

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Tissue regeneration over a large defect with a subsequent satisfactory functional recovery still stands as a major problem in areas such as nerve regeneration or bone healing. The routine technique for the reconstruction of a nerve gap is the use of autologous nerve grafting, but still with severe complications. Over the last decades several attempts have been made to overcome this problem by using biomaterials as scaffolds for guided tissue regeneration. Despite the wide range of biomaterials available, functional recovery after a serious nerve injury is still far from acceptable. Prior to th

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Sierakowska-Byczek, Aleksandra, Aleksandra Gałuszka, Łukasz Janus, and Julia Radwan-Pragłowska. "Bioactive Three-Dimensional Chitosan-Based Scaffolds Modified with Poly(dopamine)/CBD@Pt/Au/PVP Nanoparticles as Potential NGCs Applicable in Nervous Tissue Regeneration—Preparation and Characterization." Molecules 29, no. 22 (2024): 5376. http://dx.doi.org/10.3390/molecules29225376.

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Tissue engineering of nervous tissue is a promising direction in the treatment of neurological diseases such as spinal cord injuries or neuropathies. Thanks to technological progress and scientific achievements; the use of cells; artificial scaffolds; and growth factors are becoming increasingly common. Despite challenges such as the complex structure of this tissue, regenerative medicine appears as a promising future approach to improve the quality of life of patients with nervous injuries. Until now; most functional biomaterials used for this purpose were based on decellularized extra cellul

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Meyer, Cora, Lena Stenberg, Francisco Gonzalez-Perez, et al. "Chitosan-film enhanced chitosan nerve guides for long-distance regeneration of peripheral nerves." Biomaterials 76 (January 2016): 33–51. http://dx.doi.org/10.1016/j.biomaterials.2015.10.040.

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Shirosaki, Yuki, Satoshi Hayakawa, Akiyoshi Osaka, et al. "Challenges for Nerve Repair Using Chitosan-Siloxane Hybrid Porous Scaffolds." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/153808.

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The treatment of peripheral nerve injuries remains one of the greatest challenges of neurosurgery, as functional recover is rarely satisfactory in these patients. Recently, biodegradable nerve guides have shown great potential for enhancing nerve regeneration. A major advantage of these nerve guides is that no foreign material remains after the device has fulfilled its task, which spares a second surgical intervention. Recently, we studied peripheral nerve regeneration using chitosan-γ-glycidoxypropyltrimethoxysilane (chitosan-GPTMS) porous hybrid membranes. In our studies, these porous membra

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Duda, Sven, Lutz Dreyer, Peter Behrens, et al. "Outer Electrospun Polycaprolactone Shell Induces Massive Foreign Body Reaction and Impairs Axonal Regeneration through 3D Multichannel Chitosan Nerve Guides." BioMed Research International 2014 (2014): 1–16. http://dx.doi.org/10.1155/2014/835269.

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We report on the performance of composite nerve grafts with an inner 3D multichannel porous chitosan core and an outer electrospun polycaprolactone shell. The inner chitosan core provided multiple guidance channels for regrowing axons. To analyze thein vivoproperties of the bare chitosan cores, we separately implanted them into an epineural sheath. The effects of both graft types on structural and functional regeneration across a 10 mm rat sciatic nerve gap were compared to autologous nerve transplantation (ANT). The mechanical biomaterial properties and the immunological impact of the grafts

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Gonzalez-Perez, Francisco, Stefano Cobianchi, Claudia Heimann, James B. Phillips, Esther Udina, and Xavier Navarro. "Stabilization, Rolling, and Addition of Other Extracellular Matrix Proteins to Collagen Hydrogels Improve Regeneration in Chitosan Guides for Long Peripheral Nerve Gaps in Rats." Neurosurgery 80, no. 3 (2017): 465–74. http://dx.doi.org/10.1093/neuros/nyw068.

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Abstract BACKGROUND: Autograft is still the gold standard technique for the repair of long peripheral nerve injuries. The addition of biologically active scaffolds into the lumen of conduits to mimic the endoneurium of peripheral nerves may increase the final outcome of artificial nerve devices. Furthermore, the control of the orientation of the collagen fibers may provide some longitudinal guidance architecture providing a higher level of mesoscale tissue structure. OBJECTIVE: To evaluate the regenerative capabilities of chitosan conduits enriched with extracellular matrix-based scaffolds to

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Jorge, Belinha. "Journal of Computation and Artificial Intelligence in Mechanics and Biomechanics - Volume 2 - Issue 2." Journal of Computation and Artificial Intelligence in Mechanics and Biomechanics 2, no. 2 (2022): 55–110. https://doi.org/10.5281/zenodo.7493001.

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Journal of Computation and Artificial Intelligence in Mechanics and Biomechanics (JCAIMB) is a scholarly online peer review free open access journal fully sponsored by "Publicações ISEP". All manuscripts are available in the ZENODO repository database, from OpenAIRE project, allowing an automatically abstracting and indexation and free open access.   Thus, JCAIMB is committed to ensure free Open Science to both authors and readers and to publish only quality works, which are reviewed by experts in related field. Moreover, JCAIMB aims to publish quality original res

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Patel, Minal, Li Mao, Bin Wu, and Pamela VandeVord. "GDNF blended chitosan nerve guides: Anin vivostudy." Journal of Biomedical Materials Research Part A 90A, no. 1 (2009): 154–65. http://dx.doi.org/10.1002/jbm.a.32072.

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Shirosaki, Yuki, Satoshi Hayakawa, Akiyoshi Osaka, José D. Santos, and Ana C. Maurício. "Nerve Regeneration by Using of Chitosan-Silicate Hybrid Porous Membranes." Key Engineering Materials 529-530 (November 2012): 361–64. http://dx.doi.org/10.4028/www.scientific.net/kem.529-530.361.

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The treatment of peripheral nerve injuries is still one of the most challenging tasks in neurosurgery, as functional recovery is rarely satisfactory in these patients. The concept behind the use of biodegradable nerve guides is that no foreign material should be left in place after the device has fulfilled its task, so as to spare a second surgical intervention. In a previous study, flexible and biodegradable chitosan-γ-glycidoxypropyltrimethoxysilane (GPTMS) hybrid membranes exhibited better cytocompatibility in terms of osteoblastic cells than chitosan membrane. Porous chitosan hybrid membra

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Shirosaki, Yuki, Satoshi Hayakawa, Akiyoshi Osaka, et al. "Preparation of inorganic-organic hybrid membrane for peripheral nerve reconstruction." Additional Conferences (Device Packaging, HiTEC, HiTEN, and CICMT) 2013, CICMT (2013): 000173–76. http://dx.doi.org/10.4071/cicmt-wp33.

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The treatment of peripheral nerve injuries is still one of the most challenging tasks in neurosurgery, as functional recovery is rarely satisfactory in these patients. The concept behind the use of biodegradable nerve guides is that no foreign material should be left in place after the device has fulfilled its task, so as to spare a second surgical intervention. In a previous study, flexible and biodegradable chitosan-3-glycidoxypropyltrimethoxysilane (GPTMS) hybrid membranes exhibited better cytocompatibility in terms of osteoblastic cells than chitosan membrane. Porous chitosan hybrid membra

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Patel, Minal, Pamela J. Vandevord, Howard W. Matthew, Stephen De Silva, Bin Wu, and Paul H. Wooley. "Collagen—Chitosan Nerve Guides for Peripheral Nerve Repair: A Histomorphometric Study." Journal of Biomaterials Applications 23, no. 2 (2008): 101–21. http://dx.doi.org/10.1177/0885328207084521.

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Patel, Minal, Li Mao, Bin Wu, and Pamela J. VandeVord. "GDNF–chitosan blended nerve guides: a functional study." Journal of Tissue Engineering and Regenerative Medicine 1, no. 5 (2007): 360–67. http://dx.doi.org/10.1002/term.44.

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Stocco, Elena, Silvia Barbon, Aron Emmi, et al. "Bridging Gaps in Peripheral Nerves: From Current Strategies to Future Perspectives in Conduit Design." International Journal of Molecular Sciences 24, no. 11 (2023): 9170. http://dx.doi.org/10.3390/ijms24119170.

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In peripheral nerve injuries (PNI) with substance loss, where tensionless end-to-end suture is not achievable, the positioning of a graft is required. Available options include autografts (e.g., sural nerve, medial and lateral antebrachial cutaneous nerves, superficial branch of the radial nerve), allografts (Avance®; human origin), and hollow nerve conduits. There are eleven commercial hollow conduits approved for clinical, and they consist of devices made of a non-biodegradable synthetic polymer (polyvinyl alcohol), biodegradable synthetic polymers (poly(DL-lactide-ε-caprolactone); polyglyco

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Patel, Minal, Pamela J. VandeVord, Howard W. Matthew, Stephen DeSilva, Bin Wu, and Paul H. Wooley. "Functional Gait Evaluation of Collagen Chitosan Nerve Guides for Sciatic Nerve Repair." Tissue Engineering Part C: Methods 14, no. 4 (2008): 365–70. http://dx.doi.org/10.1089/ten.tec.2008.0166.

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Gonzalez-Perez, Francisco, Joaquim Hernández, Claudia Heimann, James B. Phillips, Esther Udina, and Xavier Navarro. "Schwann cells and mesenchymal stem cells in laminin- or fibronectin-aligned matrices and regeneration across a critical size defect of 15 mm in the rat sciatic nerve." Journal of Neurosurgery: Spine 28, no. 1 (2018): 109–18. http://dx.doi.org/10.3171/2017.5.spine161100.

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OBJECTIVEArtificial nerve guides are being developed to substitute for autograft repair after peripheral nerve injuries. However, the use of conduits is limited by the length of the gap that needs to be bridged, with the success of regeneration highly compromised in long gaps. Addition of aligned proregenerative cells and extracellular matrix (ECM) components inside the conduit can be a good strategy to achieve artificial grafts that recreate the natural environment offered by a nerve graft. The purpose of this study was to functionalize chitosan devices with different cell types to support re

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Patel, Minal, Pamela J. Vandevord, Howard Matthew, Bin Wu, Stephen Desilva, and Paul H. Wooley. "Video-Gait Analysis of Functional Recovery of Nerve Repaired with Chitosan Nerve Guides." Tissue Engineering 12, no. 11 (2006): 3189–99. http://dx.doi.org/10.1089/ten.2006.12.3189.

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Dietzmeyer, Nina, Zhong Huang, Tobias Schüning, et al. "In Vivo and In Vitro Evaluation of a Novel Hyaluronic Acid–Laminin Hydrogel as Luminal Filler and Carrier System for Genetically Engineered Schwann Cells in Critical Gap Length Tubular Peripheral Nerve Graft in Rats." Cell Transplantation 29 (January 1, 2020): 096368972091009. http://dx.doi.org/10.1177/0963689720910095.

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In the current study we investigated the suitability of a novel hyaluronic acid–laminin hydrogel (HAL) as luminal filler and carrier system for co-transplanted cells within a composite chitosan-based nerve graft (CNG) in a rat critical nerve defect model. The HAL was meant to improve the performance of our artificial nerve guides by giving additional structural and molecular support to regrowing axons. We filled hollow CNGs or two-chambered nerve guides with an inserted longitudinal chitosan film (CNG[F]s), with cell-free HAL or cell-free HA or additionally suspended either naïve Schwann cells

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Carvalho, Cristiana R., João B. Costa, Lígia Costa, et al. "Enhanced performance of chitosan/keratin membranes with potential application in peripheral nerve repair." Biomaterials Science 7, no. 12 (2019): 5451–66. http://dx.doi.org/10.1039/c9bm01098j.

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In this work, the physicochemical and biological effect of incorporating human hair extracted keratin in 5% degree of acetylation chitosan membranes and its possible use as a guided tissue regeneration-based membrane were investigated.

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HUANG, YI-CHENG, and YI-YOU HUANG. "TISSUE ENGINEERING FOR NERVE REPAIR." Biomedical Engineering: Applications, Basis and Communications 18, no. 03 (2006): 100–110. http://dx.doi.org/10.4015/s101623720600018x.

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Nerve regeneration is a complex biological phenomenon. Once the nervous system is impaired, its recovery is difficult and malfunctions in other parts of the body may occur because mature neurons don't undergo cell division. To increase the prospects of axonal regeneration and functional recovery, researches have focused on designing “nerve guidance channels” or “nerve conduits”. For developing tissue engineered nerve conduits, four components come to mind, including a scaffold for axonal proliferation, supporting cells such as Schwann cells, growth factors, and extracelluar matrix. This articl

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Zhang, Fengshi, Bo Ma, Qicheng Li, Meng Zhang, and Yuhui Kou. "Chitin Conduits with Different Inner Diameters at Both Ends Combined with Dual Growth Factor Hydrogels Promote Nerve Transposition Repair in Rats." Journal of Functional Biomaterials 14, no. 9 (2023): 442. http://dx.doi.org/10.3390/jfb14090442.

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Severe peripheral nerve injuries, such as deficits over long distances or proximal nerve trunk injuries, pose complex reconstruction challenges that often result in unfavorable outcomes. Innovative techniques, such as nerve transposition repair with conduit suturing, can be employed to successfully treat severe peripheral nerve damage. However, cylindrical nerve guides are typically unsuitable for nerve transposition repair. Furthermore, angiogenic and neurotrophic factors are necessary to stimulate the emergence of axonal lateral sprouts, proximal growth, and the rehabilitation of neuron stru

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Balducci, Cristian, Martina Roso, Annj Zamuner, et al. "Multilayer Electrospun Scaffolds of Opposite-Charged Chitosans." International Journal of Molecular Sciences 25, no. 6 (2024): 3256. http://dx.doi.org/10.3390/ijms25063256.

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Chitosan (CS) is a polysaccharide obtainable by the deacetylation of chitin, which is highly available in nature and is consequently low-cost. Chitosan is already used in the biomedical field (e.g., guides for nerve reconstruction) and has been proposed as a biomaterial for tissue regeneration in different body districts, including bone tissue. The interest in chitosan as a biomaterial stems from its ease of functionalization due to the presence of reactive groups, its antibacterial properties, its ease of processing to obtain porous matrices, and its inherent similarity to polysaccharides tha

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Chávez-Delgado, M. E., U. Gomez-Pinedo, A. Feria-Velasco, et al. "Ultrastructural analysis of guided nerve regeneration using progesterone- and pregnenolone-loaded chitosan prostheses." Journal of Biomedical Materials Research Part B: Applied Biomaterials 74B, no. 1 (2005): 589–600. http://dx.doi.org/10.1002/jbm.b.30243.

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Zhou, Yansheng, Ying Li, Daqing Li, Yidan Yin, and Fenglei Zhou. "Electrospun PHB/Chitosan Composite Fibrous Membrane and Its Degradation Behaviours in Different pH Conditions." Journal of Functional Biomaterials 13, no. 2 (2022): 58. http://dx.doi.org/10.3390/jfb13020058.

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Peripheral nerve injury (PNI) is a neurological disorder that causes more than 9 million patients to suffer from dysfunction of moving and sensing. Using biodegradable polymers to fabricate an artificial nerve conduit that replicates the environment of the extracellular matrix and guides neuron regeneration through the damaged sites has been researched for decades and has led to promising but primarily pre-clinical outcomes. However, few peripheral nerve conduits (PNCs) have been constructed from controllable biodegradable polymeric materials that can maintain their structural integrity or com

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Gonzalez-Perez, F., S. Cobianchi, S. Geuna, et al. "Tubulization with chitosan guides for the repair of long gap peripheral nerve injury in the rat." Microsurgery 35, no. 4 (2014): 300–308. http://dx.doi.org/10.1002/micr.22362.

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Stößel, Maria, Vivien M. Wildhagen, Olaf Helmecke, et al. "Comparative Evaluation of Chitosan Nerve Guides with Regular or Increased Bendability for Acute and Delayed Peripheral Nerve Repair: A Comprehensive Comparison with Autologous Nerve Grafts and Muscle-in-Vein Grafts." Anatomical Record 301, no. 10 (2018): 1697–713. http://dx.doi.org/10.1002/ar.23847.

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Awadhesh Kumar Pandey and Arun Kumar Dwivedi. "Recent advancement in wound healing dressing material." International Journal of Research in Pharmaceutical Sciences 10, no. 3 (2019): 2572–77. http://dx.doi.org/10.26452/ijrps.v10i3.1512.

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Wounds have been occurring as long as the existence of life. Presently available advanced wound care products for dressing are beyond the reach of the majority Indian population, and they also do not completely fulfil the required benefits of therapeutic value. The dermal patch technology is the best-known and widely used approach for delivering drugs. It has been proven to be the fastest, easiest, safest and most economical way for drug delivery. The use of biodegradable polymers in wound management has been brought into prominence with new innovations in drug delivery system. Thus with a new

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Zhu, Yaqiong, Dan Yi, Jing Wang, et al. "Harnessing three-dimensional porous chitosan microsphere embedded with adipose-derived stem cells to promote nerve regeneration." Stem Cell Research & Therapy 15, no. 1 (2024). http://dx.doi.org/10.1186/s13287-024-03753-w.

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Abstract Background Nerve guide conduits are a promising strategy for reconstructing peripheral nerve defects. Improving the survival rate of seed cells in nerve conduits is still a challenge and microcarriers are an excellent three-dimensional (3D) culture scaffold. Here, we investigate the effect of the 3D culture of microcarriers on the biological characteristics of adipose mesenchymal stem cells (ADSCs) and to evaluate the efficacy of chitosan nerve conduits filled with microcarriers loaded with ADSCs in repairing nerve defects. Methods In vitro, we prepared porous chitosan microspheres by

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Lin, Ying-Ting, Ching-Wen Li, and Gou-Jen Wang. "The Micro/Nanohybrid Structures Enhancing B35 Cell Guidance on Chitosan." Journal of Nanotechnology in Engineering and Medicine 6, no. 3 (2015). http://dx.doi.org/10.1115/1.4032602.

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A novel chitosan scaffold with micro- and nano-hybrid structures was proposed in this study. The hemispheric array of the barrier layer of an anodic aluminum oxide (AAO) film was used as the substrate. Microelectromechanical systems and nickel electroforming techniques were integrated for fabricating chitosan scaffolds with different micro/nanohybrid structures. Nerve cells were then cultured on the conduits. It was demonstrated that the scaffold with pure microstructures can guide the nerve cells to grow along the ridges of the microstructure and some cells to grow across the groove in betwee

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Shen, Xuezhen, Feng Qu, Yilun Pei, et al. "Repairing sciatic nerve injury with self-assembling peptide nanofiber scaffold-containing chitosan conduit." Frontiers in Neurology 13 (October 13, 2022). http://dx.doi.org/10.3389/fneur.2022.867711.

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BackgroundAn increasing number of nerve guide scaffolds have been used to replace the “gold-standard” autologous nerve graft for repairing peripheral nerve defects, but nerve regeneration is usually far from complete.MethodsHere, we designed and prepared two functionalized self-assembling peptides (SAP) with the IKVAV and KLT sequences, which were derived from the combination of laminin and VEGF, respectively. Their mixtures were also obtained to combine the effects of neuroprotective and neurotrophic and proangiogenic factors.ResultsThe beneficial effect of peptide gels on nerve regeneration

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Lopes, Bruna, Ana Catarina Sousa, Patrícia Sousa, et al. "In vitro evaluation of dental pulp stem cells for sciatic nerve regeneration: foundations for future in vivo applications." Frontiers in Cell and Developmental Biology 13 (February 19, 2025). https://doi.org/10.3389/fcell.2025.1528213.

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IntroductionPeripheral nerve injuries, resulting from trauma or medical interventions, present significant clinical challenges due to their severe physiological and functional impacts. Despite various therapeutic approaches, optimal methods for promoting nerve regeneration remain difficult to obtain. This study is a preliminary step towards the future use of chitosan nerve guide conduits combined with human dental pulp stem cells and their conditioned media to promote nerve regrowth in a rat model with severe sciatic nerve damage.MethodsPreliminary characterization of conditioned medium from h

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Fang, Jiaqi, Bo Xu, Xuehan Jin, et al. "Nerve Guide Conduits Integrated with Fisetin‐Loaded Chitosan Hydrogels for Reduces Oxidative Stress, Inflammation And Nerve Regeneration." Macromolecular Bioscience, January 21, 2024. http://dx.doi.org/10.1002/mabi.202300476.

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AbstractPeripheral nerve injuries represent a prevalent and severe category of damage resulting from traumatic incidents. Predominantly, the deficiency in nerve regeneration can be ascribed to enduring inflammatory reactions, hence imposing substantial clinical implications for patients. Fisetin, a flavonoid derived from plants, is naturally present in an array of vegetables and fruits, including strawberries, apples, onions, and cucumbers. It exhibits immunomodulatory properties through the reduction of inflammation and oxidative stress. In the present research, a nerve defect was addressed f

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Tereshenko, Vlad, Irena Pashkunova-Martic, Krisztina Manzano-Szalai, et al. "MR Imaging of Peripheral Nerves Using Targeted Application of Contrast Agents: An Experimental Proof-of-Concept Study." Frontiers in Medicine 7 (December 11, 2020). http://dx.doi.org/10.3389/fmed.2020.613138.

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Introduction: Current imaging modalities for peripheral nerves display the nerve's structure but not its function. Based on a nerve's capacity for axonal transport, it may be visualized by targeted application of a contrast agent and assessing the distribution through radiological imaging, thus revealing a nerve's continuity. This concept has not been explored, however, may potentially guide the treatment of peripheral nerve injuries. In this experimental proof-of-concept study, we tested imaging through MRI after administering gadolinium-based contrast agents which were then retrogradely tran

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Zhang, Xu, Tong Qi, Yu Sun, et al. "Chitosan nerve conduit filled with ZIF-8-functionalized guide microfibres enhances nerve regeneration and sensory function recovery in sciatic nerve defects." Chemical Engineering Journal, December 2023, 147933. http://dx.doi.org/10.1016/j.cej.2023.147933.

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