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Journal articles on the topic 'Chloral Hydrate, blood'

Author: Grafiati

Published: 14 December 2022

Last updated: 31 July 2025

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1

LaManna, Joseph C., and Sami I. Harik. "Regional Studies of Blood—Brain Barrier Transport of Glucose and Leucine in Awake and Anesthetized Rats." Journal of Cerebral Blood Flow & Metabolism 6, no. 6 (1986): 717–23. http://dx.doi.org/10.1038/jcbfm.1986.128.

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d-Glucose and l-leucine are transported across the blood–brain barrier (BBB) by two separate carrier-mediated facilitated diffusion mechanisms. In the awake rat there are regional differences in blood-to-brain glucose transport among the cerebral cortex, cerebellum, hippocampus, and striatum. To determine whether these are due to variations in the regional density or affinity of the glucose transporter moiety of brain capillaries or are secondary to regional tissue perfusion and capillary arrangement characteristics, we studied (a) regional blood-to-brain transport of l-leucine in awake rats;

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Lipscomb, J. C., D. A. Mahle, W. T. Brashear, and C. M. Garrett. "A Species Comparison of Chloral Hydrate Metabolism in Blood and Liver." Biochemical and Biophysical Research Communications 227, no. 2 (1996): 340–50. http://dx.doi.org/10.1006/bbrc.1996.1511.

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Xie, Hongyu, David Y. Chung, Sreekanth Kura, et al. "Differential effects of anesthetics on resting state functional connectivity in the mouse." Journal of Cerebral Blood Flow & Metabolism 40, no. 4 (2019): 875–84. http://dx.doi.org/10.1177/0271678x19847123.

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Blood oxygen level-dependent (BOLD) functional MRI (fMRI) is a standard approach to examine resting state functional connectivity (RSFC), but fMRI in animal models is challenging. Recently, functional optical intrinsic signal imaging—which relies on the same hemodynamic signal underlying BOLD fMRI—has been developed as a complementary approach to assess RSFC in mice. Since it is difficult to ensure that an animal is in a truly resting state while awake, RSFC measurements under anesthesia remain an important approach. Therefore, we systematically examined measures of RSFC using non-invasive, wi

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Wei, Hongyan, Ling Yan, Xueqing Liu, Xiaosan Feng, and Ying Liu. "Effect of White Noise Combined with Chloral Hydrate Sedation on Improving the Success Rate of MRI Examination in Neonatal." International Journal of Anesthesia and Clinical Medicine 13, no. 1 (2025): 20–23. https://doi.org/10.11648/j.ijacm.20251301.13.

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&lt;i&gt;Objective: &lt;/i&gt;Observe the sedative effect of white noise combined with hydrolytic aldarin in the newborn MRI examination. &lt;i&gt;Methods:&lt;/i&gt; Selected 70 newborns of MRI inspections received by Zhuhai City People&apos;s Hospital from November 2021 to November 2023, using random digital tables to divide them into the observation group and control group, each group of 35 cases. The control group used 10% chloral hydrate solution to perform retention enema 30 minutes before MRI examination according to the dosing standard of 0.5 ml/kg. T

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Raysky, S. M. "High blood pressure." Kazan medical journal 25, no. 11 (2021): 1232–33. http://dx.doi.org/10.17816/kazmj80514.

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High blood pressure prof. J. Pal (Die rztliche Praxis, No. 6, 1929) divides into two main forms: acute and permanent; The first is arterial spasm, and the second is the hypertensive setting of the muscle cells of the arterial wall ("Die hypertonische Einstellung der Muskelzellen der Arterienwand"), in which the prearterioles and arterioles are in a tense state, functionally giving rise to blood pressure. Recent research by the author has established the fallacy of the existing opinion that any persistently high blood pressure is the result of renal tissue disease. The author distinguishes prim

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Дубенский, А. Ю., И. А. Рыжков, К. Н. Лапин, et al. "INFLUENCE OF ANESTHESIA TYPE ON THE BLOOD CIRCULATION IN RATS." Vestnik SurGU. Meditsina 16, no. 2 (2023): 79–86. http://dx.doi.org/10.35266/2304-9448-2023-2-79-86.

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The study aims to detect the effects of non-inhaled anesthetics of two different types on the parameters of the central hemodynamics and microcirculation in an occlusive reactive hyperemia test in two groups of male Wistar rats weighting 400–500 g. The “ChH” group received 6 % chloral hydrate solution at a dose of 300 mg/kg intraperitoneally, while the “zol + xyl” group received 20 mg/kg of tiletamine/zolazepam (Zoletil 100, France) mixed with 5 mg/kg of xylazine (Xylanit, Russia) intraperitoneally. The following parameters were measured: blood pressure, average heart rate, duration of PQ, QRS

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Schmitt, Thomas C. "Determination of chloral hydrate and its metabolites in blood plasma by capillary gas chromatography with electron capture detection." Journal of Chromatography B 780, no. 2 (2002): 217–24. http://dx.doi.org/10.1016/s1570-0232(02)00371-9.

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Boz, Mustafa, Pergin Atilla, Alper B. Iskit, and Mustafa Ilhan. "Effects of ATP-sensitive potassium channel blockers on vascular hyporeactivity, mesenteric blood flow, and survival in lipopolysaccharide-induced septic shock model." Canadian Journal of Physiology and Pharmacology 94, no. 8 (2016): 858–67. http://dx.doi.org/10.1139/cjpp-2015-0381.

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In this study, the possible therapeutic effects of various ATP-sensitive potassium channel (KATP) blockers (glibenclamide, repaglinide, 5-HD, HMR-1098) have been tested in experimental septic shock model. Rats were given lipopolysaccharide (1 mg·kg−1) to create experimental shock model and 4 h later, under 400 mg·kg−1 chloral hydrate anesthesia, parameters such as blood pressure, mesenteric blood flow, the response of mesenteric circulation to phenylephrine (vasoconstrictor stimulation), and organ and oxidative damage were analyzed. Also 75 mg·kg−1 lethal dose of lipopolysaccharide was given t

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Heimann, A., S. Kroppenstedt, P. Ulrich, and O. S. Kempski. "Cerebral Blood Flow Autoregulation during Hypobaric Hypotension Assessed by Laser Doppler Scanning." Journal of Cerebral Blood Flow & Metabolism 14, no. 6 (1994): 1100–1105. http://dx.doi.org/10.1038/jcbfm.1994.144.

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Hypobaric hypotension was used to reduce systemic blood pressure in rats below the lower threshold of CBF autoregulation to evaluate a new laser Doppler (LD) “scanning” technique. Spontaneously breathing male Wistar Kyoto rats (n = 8) were anesthetized with chloral hydrate and the head fixed in a stereotaxic head holder. A cranial window with intact dura mater was introduced to assess local CBF (lCBF) by LD. One stationary probe served to detect rapid flow changes, whereas the second probe was used to sample lCBF recordings from many cortical locations by means of a stepping motor-controlled m

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Fett, Jordan, Richard Hackbarth, Brian Boville, Anthony Olivero, Alan Davis, and John Winters. "Comparative Effectiveness of Intranasal Dexmedetomidine–Midazolam versus Oral Chloral Hydrate Targeting Moderate Sedation during Pediatric Transthoracic Echocardiograms." Journal of Pediatric Intensive Care 06, no. 03 (2016): 182–87. http://dx.doi.org/10.1055/s-0036-1597696.

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Objective To compare efficacy and safety of two moderate sedation regimens for transthoracic echocardiography (TTE): intranasal dexmedetomidine–midazolam (DM) versus oral chloral hydrate (CH) syrup. Method This was a retrospective cohort of 93 children under 4 years of age receiving moderate sedation with either DM or CH for TTE from January 2011 through December 2014. Measurements and Main Results Forty-nine patients received oral CH and 44 received the intranasal combination of DM. The demographics between groups were similar except the DM patients were slightly older and heavier (each p &lt

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Lomynoha, Y. R., P. V. Zadorozhnii, V. V. Kiselev, and A. V. Kharchenko. "Synthesis of potential anticonvulsants based on chloral hydrate and carbamazepine: their spectral characteristics and in silico ADME profiling." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 5 (November 2024): 48–53. http://dx.doi.org/10.32434/0321-4095-2024-156-5-48-53.

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This paper reports the synthesis of a new potential anticonvulsant, N-(2,2,2-trichloro-1-hydroxyethyl)-5H-dibenzo[b,f]azepine-5-carboxamide. Its synthesis is based on condensing the anticonvulsant drug carbamazepine with chloral hydrate used in medical practice. The reaction was carried out in a melt or by boiling in dry benzene with the removal of the resulting water from the reaction medium. The product was obtained with yields of 88 and 79%, respectively. Replacing the hydroxyl group in the resulting condensation product with an amino group led to the formation of N-(1-amino-2,2,2-trichloro

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Bringmann, Gerhard, Ralf God, Silvia Fähr, Doris Feineis, Katalin Fornadi та Ferenc Fornadi. "Identification of the Dopaminergic Neurotoxin 1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline in Human Blood after Intake of the Hypnotic Chloral Hydrate". Analytical Biochemistry 270, № 1 (1999): 167–75. http://dx.doi.org/10.1006/abio.1999.4088.

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Adamyan, N. H., Q. M. Shamilyan, A. G. Zhamharyan, H. V. Topchyan, and M. G. Balasanyan. "Investigation of cerebrovascular activity of new GABA-derived short peptides." NEW ARMENIAN MEDICAL JOURNAL, no. 4 (2022): 89–95. http://dx.doi.org/10.56936/18290825-2022.16.4-89.

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Based on the important role of endogenous substances in the cerebral blood flow regulation, the cerebrovascular activity of new synthesized short peptides of γ-aminobutyric acid (GABA) and pyroglutamate has been investigated, considering the development of new drugs for the correction of cerebral circulation. Taking into account the proven ability to increase cerebral blood flow of γ-aminobutyric acid and its endogenous metabolites, such as gamma butyrolactone, gamma hydroxybutyric acid, pyrrolidone, pyroglutamic acid, as well as synthetic analogues, such as picamilon, the influence of pyroglu

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Ye, Weijian, Chongliang Lin, Guanyang Lin, et al. "Tissue Distribution of Engeletin in Mice by UPLC-MS/MS." Current Pharmaceutical Analysis 15, no. 6 (2019): 604–11. http://dx.doi.org/10.2174/1573412914666180501114659.

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Introduction: Engeletin is the main active component in the engelhardia leaf that promotes circulation and removes stasis, and has hypoglycemic, hypolipidemic, and anti-inflammatory actions. The aim of this study was to develop an ultra-performance liquid chromatography- tandem mass spectrometry method to detect engeletin in plasma and tissues and investigate its absorption, distribution, and mechanism in mice, which could provide very useful information for its pharmacological effect in vivo. Materials and Methods: Twenty-five mice were intraperitoneally injected with 20 mg/kg engeletin, and

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Hayashi, Naoyuki. "Exercise pressor reflex in decerebrate and anesthetized rats." American Journal of Physiology-Heart and Circulatory Physiology 284, no. 6 (2003): H2026—H2033. http://dx.doi.org/10.1152/ajpheart.00400.2002.

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I investigated whether muscular contraction evokes cardiorespiratory increases (exercise pressor reflex) in α-chloralose- and chloral hydrate-anesthetized and precollicular, midcollicular, and postcollicular decerebrated rats. Mean arterial pressure (MAP), heart rate (HR), and minute ventilation (V˙e) were recorded before and during 1-min sciatic nerve stimulation, which induced static contraction of the triceps surae muscles, and during 1-min stretch of the calcaneal tendon, which selectively stimulated mechanosensitive receptors in the muscles. Anesthetized rats showed various patterns of MA

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Ratjen, F., R. Zinman, and M. E. Wohl. "A new technique to demonstrate flow limitation in partial expiratory flow-volume curves in infants." Journal of Applied Physiology 67, no. 4 (1989): 1662–69. http://dx.doi.org/10.1152/jappl.1989.67.4.1662.

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Partial expiratory flow-volume (PEFV) curves in infants are generated by applying a compressive pressure over the chest wall with an inflatable jacket. This study addresses two issues: pressure transmission to and across the chest wall and whether flow limitation can be identified. Eleven infants sedated with chloral hydrate were studied. Pressure transmission to the chest wall, measured with neonatal blood pressure cuffs placed on the infant's body surface, was 72 +/- 4% of jacket pressure during compression maneuvers. The pressure transmission to the air spaces, determined by measuring airwa

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Martins, Emerson Fachin, and Gerson Chadi. "Glial reaction in the hippocampus after global cardiogenic ischemia." Acta Cirurgica Brasileira 16, no. 1 (2001): 05–14. http://dx.doi.org/10.1590/s0102-86502001000100003.

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Many experimental surgerical procedures have been perfomed in the analyse of the phenomenon of brain trophism and plasticity, however undesirable intercorrence can occour leading to specific changes in the results that should be taken into attention. To study this issue we have promoted a transient cardiogenic interruption of the blood flow together with a transient occlusion of the bilateral common carotid arteries (2VO) in rats and analysed the state of activation of astrocyte and microglia by means of the glial fibrillary acidic protein (GFAP) and OX42 immunohistochemistry, respectively. Ra

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Kano, Michihisa, Michael A. Moskowitz, and Masayuki Yokota. "Parasympathetic Denervation of Rat Pial Vessels Significantly Increases Infarction Volume following Middle Cerebral Artery Occlusion." Journal of Cerebral Blood Flow & Metabolism 11, no. 4 (1991): 628–37. http://dx.doi.org/10.1038/jcbfm.1991.114.

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Studies were undertaken in Long Evans rats to examine the hypothesis that chronic unilateral sectioning of vasodilating nerve fibers (parasympathetic and/or sensory) innervating the circle of Willis increases infarction volume following unilateral branch occlusion of the middle cerebral artery (MCA) combined with temporary (45 min) bilateral common carotid occlusion. Infarct size was measured 24 h after surgical occlusion from seven coronal slices. Infarction volume (mean ± SD) in sham animals (group A) and surgically naive animals (group B) measured 153 ± 43 and 131 ± 38 mm3, respectively. Af

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Шатохина, С. Н., В. В. Александрин, and В. Н. Шабалин. "Evaluation of the anesthesia depth in experimental animals by parameters of cerebral blood flow and structures of the blood serum solid phase (experimental study)." Nauchno-prakticheskii zhurnal «Patogenez», no. 3 (September 29, 2021): 24–31. http://dx.doi.org/10.25557/2310-0435.2021.03.24-31.

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Актуальность. Важным патогенетическим звеном развития осложнений при введении наркоза является нарушение дыхания в виде апноэ, которое может переходить в агонию. Вместе с тем, не существует работ по регистрации мозгового кровотока в период агонии. Несмотря на многочисленные результаты исследований на животных, демонстрирующих, что общая анестезия приводит к нейродегенерации и когнитивным нарушениям, на сегодняшний день чёткого консенсуса о влиянии анестетиков на человека всё ещё не достигнуто. Цель исследования: выявить маркёры стадий наркоза у экспериментальных животных по структурам твёрдой

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Saleh, T. M., and D. F. Cechetto. "Peptides in the parabrachial nucleus modulate visceral input to the thalamus." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 264, no. 4 (1993): R668—R675. http://dx.doi.org/10.1152/ajpregu.1993.264.4.r668.

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The role of neuropeptides in ascending visceral pathways was investigated by recording the changes in the response of thalamic neuronal activity evoked by vagal stimulation before and after peptide injection in the parabrachial nucleus (PB). Male Wistar rats (n = 25) were anesthetized with chloral hydrate and ventilated, and blood pressure and heart rate were continuously monitored. The left cervical vagus nerve was stimulated at submaximal current intensities to elicit changes in single and multiunit activity in the parvocellular visceral relay nuclei in the ventral basal thalamus. Peristimul

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Saleh, T. M., and D. F. Cechetto. "Neurochemical interactions in the parabrachial nucleus mediating visceral inputs to visceral thalamic neurons." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 268, no. 3 (1995): R786—R795. http://dx.doi.org/10.1152/ajpregu.1995.268.3.r786.

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Previously we demonstrated that glutamatergic and noradrenergic receptors mediate the relay of visceral information through the parabrachial nucleus (PBN) and that calcitonin gene-related peptide (CGRP), substance P (SP), somatostatin (SOM), neurotensin (NT), and cholecystokinin (CCK) may modulate these responses. The interactions of these neurotransmitters and neuropeptides were examined in male Wistar rats (17) that were anesthetized with chloral hydrate and ventilated and in which blood pressure and heart rate were continuously monitored. The left cervical vagus nerve was stimulated at subm

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Александрин, В. В., А. В. Иванов, and А. А. Кубатиев. "Wavelet analysis of cerebral blood flow in terminal rats." Nauchno-prakticheskii zhurnal «Patogenez», no. 1 (March 31, 2022): 69–73. http://dx.doi.org/10.25557/2310-0435.2022.01.69-73.

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В последнее десятилетие внимание клиницистов привлекает проблема церебральной гипоперфузии - диапазона ишемического мозгового кровотока от нижней границы ауторегуляции до порога некроза. Поиски методов исследования регуляции кровотока при гипоперфузии остаются актуальным научным направлением. Цель исследования. Изучить посредством лазерной допплеровской флоуметрии (ЛДФ) состояние регуляторных влияний на микрососуды мозга в условиях тяжелой ишемии. Материалы и методы. Эксперименты проведены на 10 контрольных и 10 опытных крысах под наркозом (хлоралгидрат, 400 мг/кг, в/б). Регистрацию мозгового

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Saleh, T. M., and D. F. Cechetto. "Neurotransmitters in the parabrachial nucleus mediating visceral input to the thalamus in rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 266, no. 4 (1994): R1287—R1296. http://dx.doi.org/10.1152/ajpregu.1994.266.4.r1287.

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The putative neurotransmitters in ascending visceral pathways were investigated by recording changes in the response of thalamic neuronal activity evoked by vagal stimulation before and after neurotransmitter antagonist injections into the parabrachial nucleus (PB). Male Wistar rats (n = 39) were anesthetized with chloral hydrate and alpha-chloralose, ventilated, and blood pressure and heart rate were continuously monitored. The left cervical vagus nerve was stimulated to elicit changes in single and multiunit activity in the visceral thalamus. Peristimulus-time histograms of thalamic activity

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Thaw, Andrew. "The Release of Satiety-Inducing Immune Factors in Response to Fat, Carbohydrate, and Protein Diets." Current Developments in Nutrition 4, Supplement_2 (2020): 1236. http://dx.doi.org/10.1093/cdn/nzaa057_052.

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Abstract Objectives To examine the release of satiety-inducing cytokines in response to diets rich in fat, carbohydrates or protein. Methods The feeding behavior of 40 male Sprague-Dawley rats was continuously monitored for 23 hours per day. Food was made available at 1200 each day and removed at 1800 each day. Rats were divided into 4 groups of 10 rats each and each group received a specific diet (60% fat, 60% carbohydrate, 60% protein, or normal rat chow) for 14 days. On the 15th day, rats were presented with their meal and allowed one hour to eat. Next, rats were removed from their chamber,

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Kotsyumbas, G. I., and M. R. Khalaniia. "Pathomorphology of the cerebral cortex of cats for infectious peritonitis." Scientific Messenger of LNU of Veterinary Medicine and Biotechnology 21, no. 93 (2019): 3–9. http://dx.doi.org/10.32718/nvlvet9301.

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The article presents the results of histological studies of the frontal area of the cerebral cortexб taken from 10 corpses of cats aged from 3 months to 5.5 years, in which infectious peritonitis (based on anamnesis, clinical signs, morphological and biochemical blood analysis , ultrasound diagnostics, Rivalt test and express diagnosis) was diagnosed during their life. A pathoanatomical study was conducted; samples of the frontal area of the cerebral cortex of cats, which were fixed in a 12% aqueous solution of neutral formalin, a solution of Carnoua and 96° ethyl alcohol, were selected. The h

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Засеева, А. М., В. К. Хугаева, and А. В. Ардасенов. "The effect of lymphostimulating peptide on the dynamics of mortality in experimental myocardial infarction." Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», no. 4 (December 12, 2022): 132–37. http://dx.doi.org/10.25557/0031-2991.2022.04.132-137.

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Актуальность проблемы определяется сохранением высокой смертности и инвалидизации населения страны и за рубежом от сердечно-сосудистых заболеваний, среди которых инфаркт миокарда (ИМ) занимает первое место. цель - оценка влияния лимфостимулирующего пептида на динамику летальности при экспериментальном инфаркте миокарда. методика. Экспериментально изучали роль в патогенезе ИМ активации лимфотока в микрососудах с помощью лимфостимуляторов прямого действия пептидной природы. Эксперименты выполнены на 44 белых беспородных крысах самцах, наркотизированных внутримышечным введением 8% раствора хлорал

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Amin, Ramzi, A. K. Ansyori, Riani Erna, and Lilianty Fauzi. "Anti-receptor Advanced Glycation End Products Decreases Inflammatory Pathways in Retinopathy Diabetics: In vivo Study." Open Access Macedonian Journal of Medical Sciences 8, A (2020): 414–17. http://dx.doi.org/10.3889/oamjms.2020.4293.

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BACKGROUND: Diabetic retinopathy is an emerging microvascular complication of diabetes mellitus and a causes of blindness in individuals between ages 30 and 70 years, which is characterized by increased proliferation of blood vessels, vascular occlusion, angiogenesis, loss of pericytes from retinal capillaries, microaneurysms, retinal bleeding, increased retinal capillary permeability, thickening of capillary basal membranes, and infarcts that affect the retina, induced to permanent blindness. AIM: This study aimed to find the role of receptor advanced glycation end products (RAGE) inhib

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Shabanova, Natalia B., Anastasia D. Gerashchenko, and Marina P. Efremova. "THE EFFECT OF PYRIMIDINE AND CAVINTON DERIVATIVES ON THE CHANGE BIOELECTRIC POTENTIAL IN THE CONDITIONS OF FOCAL CEREBRAL ISCHEMIA OF THE RAT BRAIN." Acta medica Eurasica, no. 1 (March 30, 2023): 101–7. http://dx.doi.org/10.47026/2413-4864-2023-1-101-107.

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Acute disorders of cerebral hemodynamics lead to the development of socially and demographically significant diseases, as a result of which they are one of the main health problems requiring a rational pharmacological approach. In the pathogenesis of pathologies of cerebral circulation, in addition to a decrease in blood flow, an important role is played by a violation of the bioelectric activity of brain tissues, which is evidenced by changes in the frequency and amplitude of oscillations on the encephalogram. Pyrimidine derivatives have proven themselves as potential cerebroprotectors, as a

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Morris, Stephen, and Teresa Brooks. "P44 Alfentanil for analgesia and sedation in children’s critical care." Archives of Disease in Childhood 108, no. 5 (2023): 24.1–24. http://dx.doi.org/10.1136/archdischild-2023-nppg.42.

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IntroductionSafe and effective sedation and analgesia in children’s critical care is a complex area of medicines use. Analgesia and sedation are needed to treat any pain during a critical care stay, and also to facilitate the delivery of invasive interventions such as mechanical ventilation and intravenous access devices.Strong opioids are a group of medicines often used to achieve good sedation and pain relief. In adult critical care, alfentanyl has become the opioid of choice as it reduces the length of stay.1 2This could be attributed to the pharmacokinetic profile of alfentanyl. Alfentanyl

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Коваленко, А. А., Г. П. Титова, and В. К. Хугаева. "Histological examination of rat small intestine after surgical removal of obturation small bowel obstruction and peptide stimulation of lymph flow." ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», no. 4() (November 21, 2018): 157–62. http://dx.doi.org/10.25557/0031-2991.2018.04.157-162.

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Оперативное лечение различных заболеваний кишечника сопровождается осложнениями в виде нарушений микроциркуляции в области анастомоза кишки. Ранее нами показана способность лимфостимуляторов пептидной природы восстанавливать нарушенную микроциркуляцию, что послужило основой для настоящего исследования. Цель работы - оценка влияния стимуляции лимфотока в стенке кишки на процессы восстановления микроциркуляции, структуры и функции тонкой кишки в области оперативного вмешательства. Методика. В экспериментах на наркотизированных крысах (хлоралгидрат в дозе 0,6 г/кг в 0,9% растворе NaCl) моделирова

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Suzuki, Chie, Mutsumi Kosugi, and Yasuhiro Magata. "Conscious rat PET imaging with soft immobilization for quantitation of brain functions: comprehensive assessment of anesthesia effects on cerebral blood flow and metabolism." EJNMMI Research 11, no. 1 (2021). http://dx.doi.org/10.1186/s13550-021-00787-6.

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Abstract Background Animal brain functions evaluated by in vivo imaging under anesthesia can be affected by anesthetic agents, resulting in incorrect assessment of physiological brain function. We therefore performed dynamic positron emission tomography (PET) imaging of conscious rats using recently reported soft immobilization to validate the efficacy of the immobilization for brain function assessments. We also determined the effects of six anesthetic agents—a mixed anesthetic agent (MMB), ketamine + xylazine (KX), chloral hydrate (Chloral), pentobarbital (PTB), propofol (PF), and isoflurane

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Kumru, S., M. Şimşek, B. Yilmaz, et al. "Differential regulation of preovulatory luteinizing hormone and follicle-stimulating hormone release by opioids in the proestrous rat." Physiological Research, 2001, 397–403. http://dx.doi.org/10.33549/physiolres.930062.

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We have investigated the role of m- and k-opioid receptors in the central control of preovulatory LH and FSH release in the proestrous rat. Animals were anesthetized with chloral hydrate at 14:00 h on proestrus day. Following femoral artery cannulation, they were mounted in a stereotaxic apparatus. Morphine and U-50488H (benzene-acetamide methane sulphonate) were infused intracerebroventricularly either alone or in combination with naloxone and MR1452, respectively. Controls received sterile saline alone. Blood samples were obtained at hourly intervals between 15:00 h and 17:00 h. Plasma LH an

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Li, Yan, Yuan Liang, Yuan-yuan Fang, et al. "Effects of sodium para-aminosalicylic acid on chelation treatment in Pb-exposed mice." Toxicology and Industrial Health, July 5, 2023. http://dx.doi.org/10.1177/07482337231183208.

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Lead (Pb) is a corrosion-resistant, heavy, non-ferrous metal. Several metal chelators have been used for the treatment of Pb poisoning. However, the efficacy of sodium para-aminosalicylic acid (PAS-Na) in enhancing Pb excretion has yet to be fully characterized. Healthy male mice (90) were divided into six groups, the normal control group was intraperitoneally (i.p.) injected with saline and the remaining group of mice i.p. 120 mg/kg Pb acetate. Four hour later, mice were subcutaneously (back) injected (s.c.) with (80, 160, 240 mg/kg) PAS-Na or 240 mg/kg edetate calcium disodium (CaNa2EDTA) or

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Gude, Philipp, Thomas P. Weber, Stefan Dazert, et al. "Comparison of cerebral oxygen desaturation events between children under general anesthesia and chloral hydrate sedation - a randomized controlled trial." BMC Pediatrics 22, no. 1 (2022). http://dx.doi.org/10.1186/s12887-022-03739-8.

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Abstract Background During pediatric general anesthesia (GA) and sedation, clinicians aim to maintain physiological parameters within normal ranges. Accordingly, regional cerebral oxygen saturation (rScO2) should not drop below preintervention baselines. Our study compared rScO2 desaturation events in children undergoing GA or chloral hydrate sedation (CHS). Methods Ninety-two children undergoing long auditory assessments were randomly assigned to two study arms: CHS (n = 40) and GA (n = 52). Data of 81 children (mean age 13.8 months, range 1–36 months) were analyzed. In the GA group, we follo

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Cipolla, Marilyn, Italo Linfante, Abe Abuchowski, Ronald Jubin, and Siu-Lung Chan. "Abstract 62: Sanguinate TM Opens Collaterals, Improves Reperfusion and Decreases Infarct in Hypertensive Rats." Stroke 48, suppl_1 (2017). http://dx.doi.org/10.1161/str.48.suppl_1.62.

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Background: The PEGylated cell-free carboxyhemoglobin gas exchanger Sanguinate TM (SG) has multiple beneficial actions that may improve stroke outcome including anti-inflammatory, vasodilatory and oxygen delivery capacity. We investigated the ability of SG to improve infarction in spontaneously hypertensive rats (SHR) that are known to have vasoconstricted pial collaterals and poor stroke outcome. Methods: SHR were treated IV with SG (8 ml/kg; n=8) or vehicle (Lactated Ringer’s; n=6) plus tPA (0.9 mg/ml) after 30 min of proximal middle cerebral artery occlusion (MCAO) by filament occlusion. Pi

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Qiu, Fubin, Rui Li, Siyu Gu, Yimin Zhao, and Linxue Yang. "The effect of iron dextran on vitamin D3 metabolism in SD rats." Nutrition & Metabolism 19, no. 1 (2022). http://dx.doi.org/10.1186/s12986-022-00681-5.

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Abstract Background Iron and vitamin D (VD) is essential to health. Previous studies have shown that iron homeostasis has a potential effect on VD metabolism, but the mechanism is not fully understood. Objectives To explore the relationship between VD metabolism and iron metabolism, as well as the regulatory mechanism of iron on VD metabolism. Methods 40 male rats were fed adaptively for 7 days and randomly divided into control (C, n = 6 normal diet) group and model (M, n = 24 iron deficient diet) by simple randomization, the latter was used to establish iron deficiency anemia (IDA) model. Aft

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West, Christopher, Mehdi Ahmadian, Erin Erskine, et al. "Experimental high-thoracic spinal cord injury reduces splanchnic sympathetic nerve activity and is associated with persistent hypotension." Physiology 38, S1 (2023). http://dx.doi.org/10.1152/physiol.2023.38.s1.5733707.

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Objective: High-thoracic spinal cord injury (SCI) is associated with blood pressure (BP) dysregulation that consists of persistent hypotension, orthostatic intolerance and autonomic dysreflexia. Whilst several mechanisms have been suggested to underlie blood pressure dysregulation post-SCI, the most common inference made is that the sub-lesional sympathetic circuitry is hypoactive due to a loss of medullary input to the sympathetic preganglionic neurons. Yet, a remarkable paucity of data exists from electrophysiological studies that have assessed sympathetic nerve activity (SNA) in the setting

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Александрин, В. В. "PARTICIPATION OF ENDOTHELIAL-NEURONAL COMPLEXES IN THE PROCESS OF AUTOREGULATION OF CEREBRAL BLOOD FLOW." Естественные и технические науки, no. 1(176) (February 20, 2023). http://dx.doi.org/10.25633/etn.2023.01.17.

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Существуют два противоречащих друг другу понятия ауторегуляци мозгового кровотока : первое подразумевает поддержание постоянства кровотока в условиях изменения перфузионного давления, а второе – подстройку кровотока под меняющиеся метаболические потребности нервных клеток. В настоящем исследовании развивается понятие модуляции, которая задает величину кровотока, поддерживаемого затем на постоянном уровне при изменениях перфузионного давления. Графически это выглядит как диагональное смещение кривой ауторегуляции. Целью исследования было зарегистрировать процесс модуляции при активной фазе ауто

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Yunosuke, Yokota, Goh Kodama, Sakuya Itou, et al. "P0523PROTECTIVE ROLE OF REGULATORY B CELLS ON THE RENAL TISSUE REPAIRMEN AFTER ISCHEMIA REPERCUSSION INJURY." Nephrology Dialysis Transplantation 35, Supplement_3 (2020). http://dx.doi.org/10.1093/ndt/gfaa142.p0523.

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Abstract Background and Aims Acute kidney injury (AKI), even if followed by renal recovery, is a risk factor for the future development of chronic kidney disease (CKD) and end- stage renal disease. It has been postulated that interleukin-10 (IL-10)-producing Regulatory B cells (Breg) play an important role for the tissue repairment in several tissues and organs. Basically, protective role of Breg has been reported in inflammatory bowel disease. In the kidney, it has been shown that IL-10 suppresses renal function decline and improves renal prognosis in IRI model, a typical model of AKI. Howeve

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Jing, Wen, Chuanfen Li, and Jingguo Zhao. "PO-111 Effects of aerobic exercise on fatty acid metabolism in liver of NAFLD Rats." Exercise Biochemistry Review 1, no. 4 (2018). http://dx.doi.org/10.14428/ebr.v1i4.9583.

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Objective Aerobic exercise can improve liver metabolic diseases such as non-alcoholic fatty liverdisease (NAFLD), but the molecular mechanism is not completely clear, which limits the applicationof aerobic exercise in the treatment and improvement of NAFLD. In this paper, the effects of aerobicexercise on the expression levels of important genes regulating fatty acid metabolism in the liver ofNAFLD rats were studied in order to explore the possible molecular mechanism of aerobic exerciseregulating hepatic fatty acid metabolism.Methods 1. Animal grouping. 36 male Sprague Dawley (SD) rats aged 2

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Ahmadian, Mehdi, Liisa Wainman, Erin Erskine, et al. "Acute Intermittent Hypoxia Induces Chemoreflex-Independent Sympathetic Plasticity and Improves Cardiovascular Function in a Rodent Model of Spinal Cord Injury." Physiology 39, S1 (2024). http://dx.doi.org/10.1152/physiol.2024.39.s1.427.

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Background: Cardiovascular complications are one of the leading causes of morbidity and mortality in people with spinal cord injury (SCI). Activation of spinal sympathetic circuitry is critical to offset cardiovascular dysregulation and disease in those with high-level SCI. Acute intermittent hypoxia (AIH) elicits plasticity (i.e., a gradual increase in nerve activity post-AIH exposure) in phrenic and non-phrenic spinal motor circuitry and improves motor function — yet the cardiovascular benefits of AIH after SCI are largely unexplored. Aims: Determine mechanisms (Aim 1) and potential benefits

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Gao, Zhao, Xingping Yang, Yuan Zhang, and Qin Xu. "OR-014 Chronic exercise potentiates anorectic effects of leptin in hypothalamic Pomc neurons." Exercise Biochemistry Review 1, no. 2 (2018). http://dx.doi.org/10.14428/ebr.v1i2.9143.

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Objective Chronic imbalance of energy homeostasis leads to obesity and metabolic mellitus, which has developed as a major public health and economic burdens around the world. Disruption of “beige” fat mediated thermogenesis and hypothalamic neurons manipulated energy intake exaggerate this process. Multiple factors including hormonal regulation, fuel availability, and behavior contribute to energy utilization. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. In the CNS, proopiomelanocortin (Pomc) neurons receive and integrate in

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