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Journal articles on the topic 'Chloramphenicol - Side effects'

Author: Grafiati

Published: 4 June 2021

Last updated: 21 February 2023

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1

Barnhill, Alison E., Matt T. Brewer, and Steve A. Carlson. "Adverse Effects of Antimicrobials via Predictable or Idiosyncratic Inhibition of Host Mitochondrial Components." Antimicrobial Agents and Chemotherapy 56, no. 8 (2012): 4046–51. http://dx.doi.org/10.1128/aac.00678-12.

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ABSTRACTThis minireview explores mitochondria as a site for antibiotic-host interactions that lead to pathophysiologic responses manifested as nonantibacterial side effects. Mitochondrion-based side effects are possibly related to the notion that these organelles are archaic bacterial ancestors or commandeered remnants that have co-evolved in eukaryotic cells; thus, this minireview focuses on mitochondrial damage that may be analogous to the antibacterial effects of the drugs. Special attention is devoted to aminoglycosides, chloramphenicol, and fluoroquinolones and their respective single sid

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Prakairungthong, S., P. Ungchoomchoke, S. Limviriyakul, K. Suvarnsit, S. Atipas, and K. Thongyai. "Efficacy of diluted vinegar in treating granular myringitis: a randomised controlled trial." Journal of Laryngology & Otology 135, no. 1 (2021): 33–38. http://dx.doi.org/10.1017/s0022215120002716.

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AbstractObjectiveThis study aimed to evaluate the outcome of granular myringitis treatment of 1 per cent diluted vinegar ear drops or 1 per cent chloramphenicol ear drops and to assess the side effects of 1 per cent diluted vinegar.MethodTwenty-four patients aged over 18 years and diagnosed with granular myringitis grade I or II within 90 days of symptom onset were included. Patients were equally randomised into either the 1 per cent diluted vinegar group or the 1 per cent chloramphenicol group. Outcome of treatment and side effects were compared between groups. The main outcome measure was co

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Power, W. J., L. M. T. Collum, D. L. Easty, et al. "Evaluation of Efficacy and Safety of Ciprofloxacin Ophthalmic Solution versus Chloramphenicol." European Journal of Ophthalmology 3, no. 2 (1993): 77–82. http://dx.doi.org/10.1177/112067219300300205.

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The results of this clinical study demonstrate that ciprofloxacin ophthalmic solution 0.3% is as safe and as effective as 0.5% chloramphenicol ophthalmic solution in the treatment of conjunctivitis and blepharitis of bacterial aetiology. Both agents achieved microbiological improvement rates in excess of 90% after 1 week's treatment. On ciprofloxacin 93.5% of patients were judged clinically cured or improved versus 84.6% on chloramphenicol after 1 week. There were no serious adverse affects. One patient in each group suffered drug-related side-effects (chemosis, erythema) which resolved on dis

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Ilić, Budimir S., Branislava D. Kocić, Vojislav M. Ćirić, Olga G. Cvetković, and Dragoljub L. Miladinović. "AnIn VitroSynergistic Interaction of Combinations ofThymus glabrescensEssential Oil and Its Main Constituents with Chloramphenicol." Scientific World Journal 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/826219.

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The chemical composition and antibacterial activity ofThymus glabrescensWilld. (Lamiaceae) essential oil were examined, as well as the association between it and chloramphenicol. The antibacterial activities of geraniol and thymol, the main constituents ofT. glabrescensoil, individually and in combination with chloramphenicol, were also determined. The interactions of the essential oil, geraniol, and thymol with chloramphenicol toward five selected strains were evaluated using the microdilution checkerboard assay in combination with chemometric methods. Oxygenated monoterpenes were the most ab

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Rohana, Hannan, Anat Hager-Cohen, Maya Azrad, and Avi Peretz. "Trend of Changes in Chloramphenicol Resistance during the Years 2017–2020: A Retrospective Report from Israel." Antibiotics 12, no. 2 (2023): 196. http://dx.doi.org/10.3390/antibiotics12020196.

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Resistant bacteria limit treatment options. This challenge has awakened interest in antibiotics that are no longer in use due to side effects, such as chloramphenicol. This work investigated trends in chloramphenicol resistance rates during 2017–2020 in bacteria isolated from diverse clinical samples at the Baruch Padeh Medical Center, Poriya, Israel. Bacteria were isolated from 3873 samples and identified using routine methods, including matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) technology. Chloramphenicol susceptibility was tested using a VITEK II instrument or b

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DENDOOVEN, L., P. SPLATT, and J. ANDERSON. "The use of chloramphenicol in the study of the denitrification process: Some side-effects." Soil Biology and Biochemistry 26, no. 7 (1994): 925–27. http://dx.doi.org/10.1016/0038-0717(94)90309-3.

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7

Navirra Ayu Khudzaifah and Maria Monica Sianita Basukiwardojo. "Determination of the optimum concentration of the coupling agent in chloramphenicol analysis." World Journal of Advanced Research and Reviews 15, no. 1 (2022): 525–33. http://dx.doi.org/10.30574/wjarr.2022.15.1.0719.

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The aim of this research is to determine the optimum concentration of the coupling agent used in chloramphenicol analysis, then calculate the limit of detection of that photometric reaction. Chloramphenicol is a colorless compound that is often abused in animals whose products are consumed by humans. Chloramphenicol has side effects on the human body. So, chloramphenicol must be analyzed. To facilitate the analysis process, chloramphenicol must be converted into colored compounds called azo compounds. To make azo compounds must go through the process of reduction, diazotization, and coupling.

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Suwalsky, M., M. A. Espinoza, I. Sánchez, and F. Villena. "X-Ray Studies on Phospholipid Bilayers. XI. Interactions with Chloramphenicol." Zeitschrift für Naturforschung C 46, no. 7-8 (1991): 647–55. http://dx.doi.org/10.1515/znc-1991-7-823.

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Abstract Chloramphenicol is a widely used antibiotic with low levels of toxicity. However, scanning electron microscopy revealed morphological changes in human erythrocytes when they interacted in vitro with therapeutical concentrations of chloram phenicol. To explain this shape change, a study concerned with the possible interactions of this antibiotic with bilayers built-up of phospholipids located in either side of the red cell membrane was performed by X-ray diffraction. Results indicated that chloramphenicol was unable to perturb in any significant extent the structure of the phospholipid

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9

Bakar, MA, AJM Morshed, F. Islam, and R. Karim. "Screening of chloramphenicol residues in chickens and fish in Chittagong city of Bangladesh." Bangladesh Journal of Veterinary Medicine 11, no. 2 (2014): 173–75. http://dx.doi.org/10.3329/bjvm.v11i2.19144.

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Chloramphenicol, an illegal antibiotic has been widely used in aquaculture and poultry as an anti-microbial agent which has been banned in many countries for its toxic side effects. A random screening of chloramphenicol residues in some poultry and fishes by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) have been carried out. The determined concentrations of chloramphenicol in farmed and wild chickens and its liver, various types of farmed fishes were in the range of minimum value of 0.133 µg/ kg to the highest value of 0.515 µg/ kg. The lowest concentration of 0.133 µg/ kg was det

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10

Eraso, Alberto Jorge, and Inés Albesa. "Eriobotrya japonica Counteracts Reactive Oxygen Species and Nitric Oxide Stimulated by Chloramphenicol." American Journal of Chinese Medicine 35, no. 05 (2007): 875–85. http://dx.doi.org/10.1142/s0192415x0700534x.

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Chloramphenicol is a toxic antibiotic used for certain infections, though aplastic anaemia is one of its side-effects. The results of our experiments showed that blood cells suffered oxidative stress in the presence of chloramphenicol, with a significant increase in reactive oxygen species (ROS) detected by luminol-chemiluminescence (CL). The extract of fruits of Eriobotrya japonica markedly decreased ROS in leukocytes and erythrocytes, the oxidative stress caused by this antibiotic. Nitro Blue Tetrazolium (NBT) assay with purified leukocytes demonstrated that the antioxidant action of E. japo

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11

Tevyashova, Anna N. "Recent Trends in Synthesis of Chloramphenicol New Derivatives." Antibiotics 10, no. 4 (2021): 370. http://dx.doi.org/10.3390/antibiotics10040370.

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Chloramphenicol (CAM), the bacteriostatic broad-spectrum antibiotic, isolated from Streptomyces venezuelae during the “golden era” of antibiotic discovery, nowadays has limited clinical potential due to adverse side effects and frequent antimicrobial resistance. Numerous CAM analogs were synthesized in order to find the derivatives with improved pharmacological properties and activity on resistant bacterial strains. This work aims to summarize the most recent achievements in obtaining new CAM analogs reported during the last five years. Current investigations are mainly focused on elucidating

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Al-Safi, Shatha Mousa, Hala Baqer Al-Bayati, Nadia K. J. Al-Dawah, and Saadia Saleh Mehdy. "Review Article. Effects of Antibiotic residues in animal products on human health and environments." Kufa Journal For Veterinary Medical Sciences 11, no. 1 (2020): 52–56. http://dx.doi.org/10.36326/kjvs/2020/v11i13302.

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Veterinary pharmaceutical products are among the most important components of animal feed production, especially antibiotics. the main use of antibiotics in animals is to treat and prevent diseases, and to promote growth. Antibiotic use in animals can cause residues of antibiotics in foods such as meat., eggs , and milk. These residues can cause numerous side effects such as human transmission of antibiotic resistant bacteria, pathological immunological effects, allergies, parasitic mutations, nephropathy (gentamicin), hepatotoxicity, reproductive disorders, toxicity to the bone marrow (chlora

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Lorenzo. "Chloramphenicol Resurrected: A Journey from Antibiotic Resistance in Eye Infections to Biofilm and Ocular Microbiota." Microorganisms 7, no. 9 (2019): 278. http://dx.doi.org/10.3390/microorganisms7090278.

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The advent of multidrug resistance among pathogenic bacteria is devastating the worth of antibiotics and changing the way of their administration, as well as the approach to use new or old drugs. The crisis of antimicrobial resistance is also due to the unavailability of newer drugs, attributable to exigent regulatory requirements and reduced financial inducements. The emerging resistance to antibiotics worldwide has led to renewed interest in old drugs that have fallen into disuse because of toxic side effects. Thus, comprehensive efforts are needed to minimize the pace of resistance by study

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Kong, C. T., D. E. Holt, S. K. Ma, A. KW Lie, and L. C. Chan. "Effects of antioxidants and a caspase inhibitor on chioramphenicol-induced toxicity of human bone marrow and HL-60 cells." Human & Experimental Toxicology 19, no. 9 (2000): 503–10. http://dx.doi.org/10.1191/096032700672635987.

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Chloramphenicol (CAP), a board spectrum antibiotic widely used in many developing countries, has toxic side effects on bone marrow, the most serious of which is aplastic anemia. Recent studies suggest that effects of CAP on suppressing hematopoietic colony formation may be abrogated by antioxidants. In addition, there is preliminary evidence that CAP induces apoptosis in hemopoietic stem cells, leading to aplastic anemia. We have been unable to demonstrate the protective effects of a variety ofantioxidants on CAP-induced suppression of burst-forming unit erythroid (BFU-E) and colony-forming un

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Miladinović, Dragoljub L., Budimir S. Ilić, Tatjana M. Mihajilov-Krstev, Jovana L. Jović, and Marija S. Marković. "In vitro Antibacterial Activity of Libanotis montana Essential Oil in Combination with Conventional Antibiotics." Natural Product Communications 9, no. 2 (2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900238.

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The chemical composition and antibacterial activity were examined of Libanotis montana Crantz subsp. leiocarpa (Heuff.) Soó. (Apiaceae) essential oil. Gas chromatography and gas chromatography/mass spectrometry were used to analyze the chemical composition of the oil. The antibacterial activity was investigated by the broth microdilution method against thirteen bacterial strains. The interactions of the essential oil and three standard antibiotics: tetracycline, streptomycin and chloramphenicol toward five selected strains were evaluated using the microdilution checkerboard assay in combinatio

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Miladinović, Dragoljub L., Budimir S. Ilić, Branislava D. Kocić, Marija S. Marković, and Ljiljana C. Miladinović. "In Vitro Trials of Dittrichia graveolens Essential Oil Combined with Antibiotics." Natural Product Communications 11, no. 6 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100642.

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The chemical composition and antibacterial activity of Dittrichia graveolens (L.) Greuter essential oil were examined. Gas chromatography and gas chromatography/mass spectrometry were used to analyze the chemical composition of the essential oil. The antibacterial activity was investigated by the broth microdilution method against thirteen bacterial strains. The interactions of the essential oil and three standard antibiotics: chloramphenicol, tetracycline and streptomycin toward five selected strains were evaluated using the microdilution checkerboard assay in combination with chemometric met

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Vagdalkar, Deepali, Muppala Hanvitha, Santosh U. Karpur, and Sanjeev D. Rao. "Bacteriological profile and the sensitivity patterns of culture positive organisms in COVID-19 positive patients." Indian Journal of Microbiology Research 8, no. 4 (2021): 285–90. http://dx.doi.org/10.18231/j.ijmr.2021.058.

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Use of antibiotics without proper confirmation carries risk of over use of antibiotics. It is associated with certain side effects like loss of natural bacterial flora present in the human body. It can lead to resistance to the bacteria due to irrational use of antibiotics. Present study was carried out to study the bacteriological profile and the sensitivity patterns of culture positive organisms in COVID-19 positive patients.Hospital based cross-sectional study was carried out from March 2021 to June 2021 in the Department of Microbiology, Malla Reddy Institute of Medical Sciences (MRIMS), H

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Giri, Ardhendu Sekhar, Animes Kumar Golder, and Sankar Chakma. "Kinetics, degradation mechanisms and antibiotic activity reduction of chloramphenicol in aqueous solution by UV/H2O2 process." Water Science and Technology 84, no. 3 (2021): 524–37. http://dx.doi.org/10.2166/wst.2021.254.

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Abstract In this study, the aim was to explore the effectiveness of the UV/H2O2 photolysis (UVP) process in terms of antimicrobial activity reduction and increasing the mean oxidation number of carbon (MONC) under the degradation of chloramphenicol (CHPL) drug. CHPL degradation kinetics and the effects of foreign anions on CHPL degradation were explored in this study. The order of the inhibition effect was found as Cl− &gt; NO3− &gt; HCO3− due to their different in HO• radical scavenging capacity. A pseudo-first-order model for CHPL degradation was well established, and the rate consta

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Chaowagul, Wipada, Wirongrong Chierakul, Andrew J. Simpson, et al. "Open-Label Randomized Trial of Oral Trimethoprim-Sulfamethoxazole, Doxycycline, and Chloramphenicol Compared with Trimethoprim-Sulfamethoxazole and Doxycycline for Maintenance Therapy of Melioidosis." Antimicrobial Agents and Chemotherapy 49, no. 10 (2005): 4020–25. http://dx.doi.org/10.1128/aac.49.10.4020-4025.2005.

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ABSTRACT Melioidosis (infection caused by Burkholderia pseudomallei) requires a prolonged course of oral antibiotics following initial intravenous therapy to reduce the risk of relapse after cessation of treatment. The current recommendation is a four-drug regimen (trimethoprim [TMP], sulfamethoxazole [SMX], doxycycline, and chloramphenicol) and a total treatment time of 12 to 20 weeks. Drug side effects are common; the aim of this study was to compare the efficacy and tolerance of the four-drug regimen with a three-drug regimen (TMP-SMX and doxycycline). An open-label, randomized trial was co

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Rublenko, N. M., and A. M. Holovko. "Antimicrobial susceptibility of isolates of Salmonella enterica subsp. Enterica isolated in Ukraine during the period of 2014–2017." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 22, no. 97 (2020): 58–68. http://dx.doi.org/10.32718/nvlvet9711.

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The results of the study of sensitivity to antibacterial drugs in isolates of Salmonella enterica isolated from poultry are shown in the article. Antibacterial sensitivity was determined by disc diffusion to such drugs: ampicillin, cefoperazone, ceftriaxone, ceftazidime, tetracycline, doxycycline, streptomycin, gentamicin, nalidixic acid, chloramphenicol, ciprofloxacin, trimethoprim. Growth retardation zones were interpreted according to the CLSI standard. Among the isolates tested, a significant percentage of isolates resistant to nalidixic acid and ciprofloxacin were found – (19 (63.3 %) and

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Yudi Cahyoko, Ekasari, Wahju Tjahjaningsih,. "Daya Antibakteri Tepung Cacing Tanah (Lumbricus rubellus) Terhadap Pertumbuhan Bakteri Vibrio harveyi Secara In Vitro [Antibacterial Activity Of Earthworm Powder (Lumbricus rubellus) To Vibrio harveyi Growth’s In Vitro]." Jurnal Ilmiah Perikanan dan Kelautan 4, no. 1 (2019): 1. http://dx.doi.org/10.20473/jipk.v4i1.11575.

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Abstract Vibrio harveyi is the most common pathogenic agent of Penaeus monodon and causing large economic losses to the shrimp farming industry. Antibiotic has been used as the diseases treatment, but it has been banned due to the side effects. This problem was required an alternative solution by using natural material, such as earthworm powder (L. rubellus). This research was conducted to know the bacterial growth inhibition V. harveyi by using earthworm powder (L. rubellus). The research method is experimental and data analysis done descriptively. Inhibition of V. harveyi growth was tested u

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Treiber, Fritz Michael, and Heide Beranek-Knauer. "Antimicrobial Residues in Food from Animal Origin—A Review of the Literature Focusing on Products Collected in Stores and Markets Worldwide." Antibiotics 10, no. 5 (2021): 534. http://dx.doi.org/10.3390/antibiotics10050534.

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The extensive use of antibiotics leads to antibiotic residues in frequently consumed foods. Generally, the main use of antibiotics in animals is to treat and prevent diseases and growth promotion. However, the residues and their breakdown products have several side effects on the human body and, in a broader sense, on the environment. In relation to the human body, the frequency of mutations is increased, the bone marrow is damaged (chloramphenicol), and the reproductive organs of humans are affected. Carcinogenic effects have been found with antibiotics such as sulfamethazine, oxytetracycline

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Fatimah, Siti, Yuliana Prasetyaningsih, and Riska Amelia. "Daya Antibakteri Ekstrak Etanol Daun Kubis (Brassica oleracea var.capitata f.alba) Terhadap Bakteri Escherichia coli Secara In Vitro." Journal of Health 3, no. 2 (2016): 62. http://dx.doi.org/10.30590/vol3-no2-p62-68.

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Background :. Escherichia coli is a bacteria cause of infections such as diarhea and urinary tractus infection. Antibiotic used for treatment of diarhea and urinary tractus infection include ampicilin, penicilin G, amoxicilin, chloramphenicol, tetracycline, and sulbenicin. These antibiotic are often used, but it has some side effects as well as the emergence of resistance. Treatment with minimal effects and does not cause mildew resistance continue to alternative antibacteria. Cabbage leaf is a vegetable which contains flavonoid, saponin, polifenol, and tanin that are antibacteria. The purpose

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Silina, Ekaterina, Victor Stupin, Natalia Manturova, et al. "Acute Skin Wounds Treated with Mesenchymal Stem Cells and Biopolymer Compositions Alone and in Combination: Evaluation of Agent Efficacy and Analysis of Healing Mechanisms." Pharmaceutics 13, no. 10 (2021): 1534. http://dx.doi.org/10.3390/pharmaceutics13101534.

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We studied the efficacy of using mesenchymal stem cells (MSC) and a polymeric compound (based on chitosan and cellulose with integrated cerium dioxide nanoparticles (PCCD)) in wound healing, and to compare the effects with various invasive and external drugs used for the same purpose. Two wounds were made on the backs of each of 112 Wistar rats, removing the skin. Eight groups were studied: Control_0—intact wounds; Control_ss—0.9% NaCl injections; MSC injections; Control_msc—intact wounds on the opposite side of the body from the MSC group; external application of the PCCD; external applicatio

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López, Elena, and Jesús Blázquez. "Effect of Subinhibitory Concentrations of Antibiotics on Intrachromosomal Homologous Recombination in Escherichia coli." Antimicrobial Agents and Chemotherapy 53, no. 8 (2009): 3411–15. http://dx.doi.org/10.1128/aac.00358-09.

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ABSTRACT Subinhibitory concentrations of some antibiotics, such as fluoroquinolones, have been reported to stimulate mutation and, consequently, bacterial adaptation to different stresses, including antibiotic pressure. In Escherichia coli, this stimulation is mediated by alternative DNA polymerases induced via the SOS response. Sublethal concentrations of the fluoroquinolone ciprofloxacin have been shown to stimulate recombination between divergent sequences in E. coli. However, the effect of ciprofloxacin on recombination between homologous sequences and its SOS dependence have not been stud

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O. Amadi, Lawrence, Faith T, Emeka, and Grace I, Lekia. "Biofilm Production in Borehole Water Sources and their Susceptibility to Antibiotics and Antibiofilm Effect of Noni Foliar Extracts." South Asian Journal of Research in Microbiology 14, no. 3 (2022): 24–33. http://dx.doi.org/10.9734/sajrm/2022/v14i3273.

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Background: Bacteria produce biofilm in a variety of systems; water, implant devices in humans and living tissues. They can be persistent and express virulent factors, increased resistance to antimicrobials and human immunity. Plant-based extracts have shown promising outcomes in inhibiting quorum sensing system and modulation of biofilm formation with lesser side effects. Thus, foliar extracts of Noni plant was the subject of such trial as an antibiofilm/antibacterial agent.  Objective: Investigate borehole water sources from three communities in Port Harcourt Local Government Area (PHA

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Kofogoue, Achille C., Cedric F. Tchinda, Armelle T. Mbaveng, and Victor Kuete. "Antibacterial and antibiotic-potentiating activities of Desmodium uncinatum, Neoboutonia glabrescens, Ternstroemia cameroonensis and eight other Cameroonian medicinal plants against multi-drug resistant bacteria expressing active efflux pumps." Investigational Medicinal Chemistry and Pharmacology 5, no. 1 (2022): 1–16. http://dx.doi.org/10.31183/imcp.2022.00062.

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Background: Infectious diseases remain a major public health problem in the world with a considerable impact in developing countries. Bacterial infections are of increasing concern due to the emergence and spread of bacteria resistant to antibiotics. Thus, it is necessary to develop methods and means to tackle drug resistance. The present study aimed at evaluating the antibacterial and antibiotic-potentiating activities of eleven Cameroonian medicinal plants: Sambucus nigra, Erigeron floribundus, Desmodium uncinatum, Neoboutonia glabrescens, Ficus exasperata, Sida rhombifolia, Echinaceae augus

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Abdul-Nabi AL-Nasiry, Ban Sahib. "Pathological changes of Salmonella typhimurim and treatments with some extracts of Cinnomomum zeylanicum and comparing with chloramphenicol in mice." Biochemical and Cellular Archives, October 15, 2022, 3719–28. http://dx.doi.org/10.51470/bca.2022.22.2.3719.

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The study aimed to illustrate the effect of alcoholic and oil extracts of Cinnomomum zeylanicum (cin. Zey.) on pathogenicity of Salmonella typhimurim (sal.T.m.) in mice infected experimentally and comparison of the action of these extracts with chloramphenicol antibiotic. 60 white mice were divided into six groups, they all orally infected with 6x107 cfu /ml of (sal.T.m.), five groups were treated using different ways and only one was a positive control group. The results demonstrated typical pathological pictures of salmonellosis in control group (G1). Also, the infection was clear of the gro

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Novaes, Stefani Faro de, Lígia Lindner Schreiner, Isabella Pereira e. Silva, and Robson Maia Franco. "Residues of veterinary drugs in milk in Brazil." Ciência Rural 47, no. 8 (2017). http://dx.doi.org/10.1590/0103-8478cr20170215.

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ABSTRACT: Veterinary drugs are used in dairy cattle management mainly for therapy and prophylaxis of diseases, which chemicals may leave residues in milk. Human exposure and the unintentional consumption of residues of drugs can lead to side effects and development of resistant bacteria, representing a considerable concern to consumer health. This paper presents the occurrence of residues of veterinary drugs in milk from 2009 to 2011 in Brazil, monitored by the Official Program for Analysis of Residues of Veterinary Drugs in Foods of Animal Origin. A total of 961 samples were collected in the

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Tewkesbury, Daniel H., Evelyn Looi, Peter J. Barry, et al. "Isolation of Exophiala dermatitidis is not associated with worse clinical outcomes during acute pulmonary exacerbations in cystic fibrosis." Journal of Medical Microbiology 71, no. 5 (2022). http://dx.doi.org/10.1099/jmm.0.001431.

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Introduction. The black yeast Exophiala dermatitidis has been isolated in respiratory samples from people with cystic fibrosis (CF). However, adequate detection may require longer incubation periods than the current UK national standard for CF respiratory samples. Furthermore, it is unclear whether isolation of E. dermatitidis is associated with poorer clinical outcomes in CF. Hypothesis/gap statement. E. dermatitidis does not cause clinically significant lung disease in CF adults. Aim. To evaluate differences in clinical outcomes over a 12 month period and during acute pulmonary exacerbations

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