Academic literature on the topic 'Chlordiazepoxide'

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Journal articles on the topic "Chlordiazepoxide"

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Lech, Anna, Patrycja Garbacz, Artur Sikorski, Maria Gazda, and Marek Wesolowski. "New Saccharin Salt of Chlordiazepoxide: Structural and Physicochemical Examination." International Journal of Molecular Sciences 23, no. 19 (2022): 12050. http://dx.doi.org/10.3390/ijms231912050.

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Since the formation of organic salts can improve the solubility, bioavailability, and stability of active pharmaceutical ingredients, the aim of this work was to prepare an organic salt of chlordiazepoxide with saccharin. To achieve this goal, the saccharin salt of chlordiazepoxide was obtained from a physical mixture of both components by grinding them with a small volume of solvent and by crystallizing them with complete evaporation of the solvent. The resulting salt was examined by methods such as Powder X-ray Diffraction (PXRD), Single Crystal X-ray Diffraction (SCXRD), Differential Scanni
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Nokhodchi, Ali, Roya Talari, Hadi Valizadeh, and Mohammad Barzegar Jalali. "An investigation on the solid dispersions of chlordiazepoxide." International Journal of Biomedical Science 3, no. 3 (2007): 210–16. http://dx.doi.org/10.59566/ijbs.2007.3210.

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The aim of this study was to prepare solid dispersions of chlordiazepoxide techniques to improve its dissolution rate. To this end, three techniques namely, two solvent methods and co-grinding technique were used. Solid dispersions of chlordiazepoxide in polyvinylpyrrolidone (PVP), Eudragit E100, Mannitol and Sorbitol with two different ratios of drug to carrier (5:5 and 1:9) were prepared. These solid dispersions were evaluated using dissolution tester to monitor dissolution behaviour and Fourier-transform infrared spectroscopy to investigate interaction between the drug and carriers in solid
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Harvey, S. "Benzodiazepine antagonism of thyrotrophin-releasing hormone receptors: biphasic actions on growth hormone secretion in domestic fowl." Journal of Endocrinology 137, no. 1 (1993): 35–42. http://dx.doi.org/10.1677/joe.0.1370035.

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ABSTRACT Benzodiazepines are pharmacological agents widely used for their anxiolytic and anticonvulsant properties. However, as these drugs are known to antagonize the binding and action of thyrotrophin-releasing hormone (TRH) in pituitary tissue, the possibility that they may modulate GH secretion was investigated in domestic fowl, in which TRH is a GH-releasing factor. Chlordiazepoxide (an antagonist of central-type benzodiazepine receptors) had no significant effect on the basal release of GH from incubated chicken pituitary glands, but at concentrations > 10 μmol/l chlordiazepoxide supp
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Balston, Alfred, Kuljit Hunjan, and Michael J. Kelleher. "The use of chlordiazepoxide for outpatient gamma-butyrolactone (GBL) detoxification: An observational study." Drug Science, Policy and Law 9 (January 2023): 205032452311675. http://dx.doi.org/10.1177/20503245231167544.

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Background Various detoxification regimens are used for gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL), including diazepam, barbiturates, baclofen and GHB itself. However, these regimens are primarily derived from inpatient units, and literature on outpatient GBL detoxification is sparse with no previous reports on chlordiazepoxide. We describe the characteristics of outpatient GBL detoxification using chlordiazepoxide. Methods Observational study of all patients who attended a community outpatient addiction service in South London between August 2015 and November 2017 seeking detox
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&NA;. "Chlordiazepoxide withdrawal." Reactions Weekly &NA;, no. 647 (1997): 7. http://dx.doi.org/10.2165/00128415-199706470-00017.

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Hoey, Lori L., Avi Nahum, and Kyle Vance‐Bryan. "A Prospective Evaluation of Benzodiazepine Guidelines in the Management of Patients Hospitalized for Alcohol Withdrawal." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 14, no. 5 (1994): 579–85. http://dx.doi.org/10.1002/j.1875-9114.1994.tb02854.x.

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Our institution adopted guidelines for the selection of benzodiazepines to be administered to patients hospitalized for alcohol withdrawal. We assessed the guidelines' impact on prescribing habits, benzodiazepine dosage requirements and costs, and length of intensive care unit (ICU) stay. A 6‐month prospective, observational study was performed in 50 patients who exhibited signs of alcohol withdrawal and received benzodiazepine therapy. Appropriate therapy was defined as lorazepam for patients 60 years and older or those with hepatic dysfunction, and chlordiazepoxide for all other patients. Be
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Jawaro, Tara, Ayan Kumar, Oleksandr Pistun, and Deepali Dixit. "Stevens-Johnson Syndrome Associated With Chlordiazepoxide." Journal of Pharmacy Technology 34, no. 2 (2018): 82–85. http://dx.doi.org/10.1177/8755122517753595.

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Objective: To report a case of chlordiazepoxide-associated Stevens-Johnson syndrome (SJS). Case Summary: This case provides insight into a serious adverse drug reaction secondary to a drug not commonly associated with SJS. A 29-year-old female presented with a 4-day history of rash and pruritus. The rash started on her arms and spread all over her body. The patient was started on chlordiazepoxide 3½ weeks ago. On examination, there were multiple, raised, round erythematous lesions in various stages of healing. Skin erosions were noted on her lips and buccal mucosa. However, the rash did not in
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Nisbett, Khalin E., Leandro F. Vendruscolo, and George F. Koob. "Indulging Curiosity: Preliminary Evidence of an Anxiolytic-like Effect of Castor Oil and Ricinoleic Acid." Nutrients 16, no. 10 (2024): 1527. http://dx.doi.org/10.3390/nu16101527.

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In the process of validating the elevated zero maze, a common test of anxiety-like behavior, in our laboratory, we demonstrated an anxiolytic-like effect of castor oil and its primary component, ricinoleic acid. We tested the effects of vehicle and chlordiazepoxide in male mice in the elevated zero maze following a 30-min pretreatment time. Chlordiazepoxide is a United States Food and Drug Administration-approved drug that was previously shown to exert anxiolytic-like effects in both the elevated zero maze and elevated plus maze. Chlordiazepoxide was administered at doses of 5 or 10 mg/kg. We
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&NA;. "Chlordiazepoxide/clidinium bromide." Reactions Weekly &NA;, no. 868 (2001): 8. http://dx.doi.org/10.2165/00128415-200108680-00018.

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Fischer, Andreas. "Chlordiazepoxide dichloromethane monosolvate." Acta Crystallographica Section E Structure Reports Online 68, no. 4 (2012): o1011. http://dx.doi.org/10.1107/s1600536812009695.

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In the title compound (systematic name: 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide dichloromethane monosolvate), C16H14ClN3O·CH2Cl2, the seven-membered ring adopts a boat conformation with the CH2group as the prow and the two aromatic C atoms as the stern. The dihedral angle between the benzene rings is 75.25 (6)°. The crystal structure features centrosymmetric pairs of chlordiazepoxide molecules linked by pairs of N—H...O hydrogen bonds, which generateR22(12) loops.
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Dissertations / Theses on the topic "Chlordiazepoxide"

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McCullough, Trevor. "Intracerebroventricular chlordiazepoxide and the partial reinforcement extinction effect." Thesis, University of Ulster, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284859.

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Vickers, Gary John Carleton University Dissertation Psychology. "The effects of chlordiazepoxide and RO15-4513 on cocaine self-administration." Ottawa, 1993.

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Padlubnaya, Diana B. "Effects of dizocilpine, chlordiazepoxide, and scopolamine alone and in combination on a multiple-component, repeated-acquisition test of spatial learning /." Electronic version (PDF), 2003. http://dl.uncw.edu/etd/2003/padlubnayad/dianapadlubnaya.html.

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Becerra, Andrea Milena Garcia. "Os efeitos farmacológicos de drogas ditas ansiolíticas e ansiogênicas administradas em ratos testados no labirinto em cruz elevado na presença e ausência de luminosidade." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/59/59134/tde-07022007-085305/.

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Há relatos de que doses baixas de pentilenotetrazol (PTZ) apresentam um efeito ansiogênico em testes comportamentais que medem ansiedade. No labirinto em cruz elevado a droga reduz a porcentagem de entradas e o tempo gasto nos braços abertos. O clordiazepóxido (CDP), por outro lado, é uma droga que tem efeitos ansiolíticos, aumentando a exploração dos braços abertos do labirinto ao reduzir a aversão natural dos ratos aos braços abertos. Obtém-se um efeito similar quando o teste ocorre no escuro. Cafeína (CAF) é um composto estimulante que, aplicada em baixas doses, estimula a atividade motora
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Foister, Nicola. "Behavioural phenotyping of mice with genetic alterations of the GABA[subscript A] receptor." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/988.

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GABA is the main inhibitory neurotransmitter of the central nervous system. GABA[subscript A]Rs are multimeric transmembrane receptors, which are composed of 5 subunits. It is known that there are 19 subunits that can make up the GABA[subscript A]Rs, allowing for a vast array of receptor subtypes. In addition to the GABA binding site GABA[subscript A]Rs have distinct allosteric binding sites for benzodiazepines, barbiturates, ethanol, certain general anaesthetics and neuroactive steroids. The molecular heterogeneity of the GABA[subscript A]R is accompanied by distinct pharmacological profiles
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Thullier, Francine. "Contribution à l'étude de la différenciation comportementale dans des groupes de rats soumis à une difficulté d'accès a la nourriture : influence de l'effectif, approche pharmacologique (effets du chlordiazepoxyde sur des rats de différents profils)." Nancy 1, 1992. http://www.theses.fr/1992NAN10036.

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Colin et Desor ont décrit un phénomène de différenciation comportementale dans des groupes de six rats lorsque l'accès à la nourriture est rendu difficile par l'immersion progressive de la seule voie d'accès. Il y a alors deux catégories principales qui apparaissent: des rats transporteurs qui plongent et rapportent la nourriture dans la cage et des non-transporteurs qui restent dans la cage et pour se nourrir volent la nourriture à leurs congénères. L'objectif de ce travail a été double: fondamental en poursuivant l'étude de ce phénomène, et appliqué en cherchant à adapter cette situation pou
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Bonuti, Rafael Carvalho. "Um estudo do comportamento social de duplas de ratos (Rattus norvegicus)." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/59/59134/tde-14012015-111252/.

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Uma das dificuldades de se estudar o comportamento social é que para que ele ocorra são necessários pelo menos dois sujeitos, o que dificulta medidas de um deles, sem que seja necessário levar em conta o comportamento do outro. O presente trabalho investiga o comportamento social de duplas de ratos separados por uma grade, para minimizar o efeito que o comportamento de um rato possa ter sobre o outro. Como equipamento, foi utilizado um campo aberto de madeira (120 x 120 x 40 cm) forrado de fórmica marrom escuro. Uma das paredes podia estar intacta ou apresentar uma abertura por onde se podia a
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Books on the topic "Chlordiazepoxide"

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Arabshahi, Nikzad. Chlordiazepoxide: Nikzad Arabshahi, Parichehr Tayebi. Etemad Gallery, 2012.

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McCullough, Trevor. Intracerebroventricular chlordiazepoxide and the partial reinforcement extinction effect. The Author], 1996.

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Entwistle, Neil. Chlordiazepoxide breakdown in human viscera: An investigation into the degradation of chlordiazepoxide in human bloodand liver samples. 1987.

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Ulrich, Jeffrey. Chlordiazepoxide: A Proven Guide to the Treatment of Alcoholism,its Understanding and Withdrawal. Independently Published, 2019.

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Bonn, Universität, ed. Einfluss von Alter und Geschlecht auf die Kinetik des Benzodiazepins Chlordiazepoxid: Beziehungen zur Antipyrin-Clearance. 1990.

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Book chapters on the topic "Chlordiazepoxide"

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Courtney, John C. "Chlordiazepoxide." In Encyclopedia of Clinical Neuropsychology. Springer New York, 2011. http://dx.doi.org/10.1007/978-0-387-79948-3_1636.

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Courtney, John C., and Efrain Antonio Gonzalez. "Chlordiazepoxide." In Encyclopedia of Clinical Neuropsychology. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56782-2_1636-2.

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Courtney, John C., and Efrain Antonio Gonzalez. "Chlordiazepoxide." In Encyclopedia of Clinical Neuropsychology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_1636.

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Hoyer, Daniel, Eric P. Zorrilla, Pietro Cottone, et al. "Chlordiazepoxide." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1731.

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Balogh, Nicholas J. "Chlordiazepoxide." In Encyclopedia of Child Behavior and Development. Springer US, 2011. http://dx.doi.org/10.1007/978-0-387-79061-9_1653.

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Maxwell, Robert A., and Shohreh B. Eckhardt. "Chlordiazepoxide and Diazepam." In Drug Discovery. Humana Press, 1990. http://dx.doi.org/10.1007/978-1-4612-0469-5_13.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of copper(II) complex with chlordiazepoxide." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54237-8_216.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of copper(II) complex with chlordiazepoxide." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54237-8_217.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of copper(II) complex with chlordiazepoxide." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54237-8_218.

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Benkert, Otto, Ion Anghelescu, Christoph Fehr, et al. "Chlordiazepoxid." In Pocket Guide Psychopharmaka von A bis Z. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-01910-4_20.

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Conference papers on the topic "Chlordiazepoxide"

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Walsh, B. C. "Chlordiazepoxide Induced Steven-Johnson Syndrome." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6125.

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Al-Samarrai, Teeba A., and Khalaf F. Al-Samarrai. "Spectrophotometric determination of chlordiazepoxide with 2-(chloromethyl)-5-methyl-1H-benzo [d] imidazole reagent." In 1ST SAMARRA INTERNATIONAL CONFERENCE FOR PURE AND APPLIED SCIENCES (SICPS2021): SICPS2021. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0121414.

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