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Dissertations / Theses on the topic 'Chloride channels'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Low, Wendy. "Chloride channels in epithelia." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68206.

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The outwardly rectifying chloride channel is found in most vertebrate cells however its physiological role is uncertain. Patch clamp, short-circuit current, and electronic cell sizing techniques were used to investigate the role of the outward rectifier in transepithelial chloride secretion and cell volume regulation, the two main functions that have been proposed for this channel in epithelia. Patch clamp studies of the human cell lines PANC-1 and T$ sb{84}$ showed that the chloride channel blockers IAA-94 and NPPB decrease the open probability of the outward rectifier, with half-maximal inhi

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2

Thompson, Christopher Hal. "Identification and characterization of a peptide toxin inhibitor of ClC-2 chloride channels." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26604.

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Thesis (Ph.D)--Biology, Georgia Institute of Technology, 2009.<br>Committee Chair: McCarty, Nael; Committee Co-Chair: Harvey, Stephen; Committee Member: Hartzell, Criss; Committee Member: Kubanek, Julia; Committee Member: Lee, Robert. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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3

Sabanov, Victor. "Chloride Channels and Brown Fat Cells." Doctoral thesis, Stockholm : Department of Physiology, Wenner-Gren Institute, Arrhenius Laboratories, Stockholm University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-474.

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4

Bhandal, Narotam Singh. "Arthropod chloride channels as targets for pesticides." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335651.

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5

Pifferi, Simone. "Calcium Activated Chloride Channels In Olfactory Transduction." Doctoral thesis, SISSA, 2008. http://hdl.handle.net/20.500.11767/4668.

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Ca2+-activated Cl ̄ channels are an important component of olfactory transduction. Odorant binding to odorant receptors in the cilia of olfactory sensory neurons (OSNs) leads to an increase of intraciliary Ca2+ concentration by Ca2+ entry through cyclic nucleotide-gated channels. Ca2+ activates a Cl ̄ channel that leads to an efflux of Cl ̄ from the cilia, contributing to the amplification of the OSN depolarization. The molecular identity of this Cl ̄ channel remains elusive. Recent evidences have indicated that bestrophins are able to form Ca2+-activated Cl ̄ channels channels in heterologous

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6

Joo, Nam Soo. "Regulation of duodenal ion transport by uroguanylin and cloning of murine intestinal CIC-2 chloride channel." free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9924893.

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7

Sin, Sai-lung Steven, and 冼世隆. "Chloride channel in glioma cell invasion." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41508555.

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8

Sin, Sai-lung Steven. "Chloride channel in glioma cell invasion." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508555.

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9

Halstead, Meredith. "Putative glutamate-gated chloride channels from Onchocerca volvulus." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29439.

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Onchocerca volvulus, a filarial nematode, is the causative agent of onchocerciasis.<br>O. volvulus is a human parasite with no animal model host and is endemic in the tropics. O. volvulus material is scarce and must be conserved as part of the Onchocerciasis Control Program. A genomic library was constructed to provide a substantial source of renewable genetic material, in place of original parasite DNA.<br>Currently there is only one glutamate-gated chloride channel that has been sequenced from O. volvulus, but this has not yet been characterized. This GluClx partial cDNA sequence isolated by

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10

Starc, Tanja. "Structure function analysis of glutamate gated chloride channels." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79135.

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Glutamate-gated chloride channels (GluCl) belong to then icotinic ligand-gated ion channel family and are thus assumed to be heteropentamers. Each subunit contains a large extracellular N-terminal domain, four transmembrane domains (TM1--TM4), and an extracellular C terminal. Caenorhabditis elegans expresses various GluCl channels formed by alpha1, alpha2, alpha3, alpha4 and beta subunits. The best understood GluCl channel is expressed in pharyngeal muscle cells where it mediates response to the M3 motor neuron. alpha2 forms this channel, probably in association with beta. The alpha2 mu

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11

Zeltwanger, Shawn. "Gating of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels by nucleoside triphosphates." free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9924950.

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12

Mahankali, Uma. "Computer Simulation Studies of CLC Chloride Channels and Transporters." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1157115905.

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13

Yates, Darran Michael. "Characterisation of glutamate-gated chloride channels from Dirofilaria immitis." Thesis, University of Bath, 2003. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426178.

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14

Horoszok, Lucy. "Characterisation of glutamate-gated chloride channels from Caenorhabditis elegans." Thesis, University of Bath, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341158.

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15

Portillo, Maria Virginia. "Distribution and function of nematode glutamate-gated chloride channels." Thesis, University of Bath, 2003. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398437.

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16

Amjad, Asma. "Calcium-activated chloride channels in mouse vomeronasal sensory neurons." Doctoral thesis, SISSA, 2013. http://hdl.handle.net/20.500.11767/3899.

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In vomeronasal sensory neurons, signal transduction occurs in microvilli that are present at the neuron’s apical surface. The binding of pheromone to vomeronasal receptors causes an increase of the intracellular calcium concentration by calcium entry through TRPC2. An important issue is the impact of Ca2+ entry in pheromonal transduction. In the first part of this thesis we have investigated the functional role played by the increase in intracellular Ca2+ concentration in the apical region of vomeronasal sensory neurons. By taking advantage of flash photolysis of caged calcium restricted to t

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17

Gruis, Darren Ben. "The cystic fibrosis transmembrane conductance regulator : advancement of the structural model of the protein and development of a novel approach to understand defective protein processing related to cystic fibrosis /." free to MU campus, to others for purchase, 1999. http://wwwlib.umi.com/cr/mo/fullcit?p9946257.

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18

Reynolds, Annie 1978. "Over-expression of the potassium-chloride co-transporter KCC2 in developing zebrafish." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98778.

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In embryonic neurons, the intracellular chloride concentration is elevated, making GABA and glycine depolarizing. Later in development, coincident with neuronal maturation, the extruding potassium-chloride co-transporter KCC2 is expressed. It reverses the chloride gradient, rendering it hyperpolarizing. Early depolarization is assumed to play trophic roles during nervous system development. I thus decided to investigate the effects of the depolarizing chloride gradient on development in vivo in the zebrafish embryo. I first determined the temporal pattern of KCC2 expression in zebrafish and fo

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19

Shu, Yali. "Regulation of human airway epithelial chloride channels by matrix metalloproteinases." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ34416.pdf.

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20

Tan, Hua [Verfasser]. "CLC CHLORIDE CHANNELS IN INHERITED DEAFNESS AND HYPERALDOSTERONISM / Hua Tan." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1172967997/34.

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21

Delany, Natalie Samantha. "Glutamate-gated chloride channels in the parasitic nematode, Haemonchus contortus." Thesis, University of Bath, 1998. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263228.

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22

Alam, Sabina. "Detection of ligand-gated chloride ion channels on human lymphocytes." Thesis, University of Bath, 2004. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413064.

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23

Varandani, Anjali. "Adenosine 3', 5'-cyclic monophosphate activation of islet chloride channels." VCU Scholars Compass, 1998. https://scholarscompass.vcu.edu/etd/5621.

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The objective of this thesis was to understand the regulation of islet Cl⁻ current by cAMP. This current, known as Icl,islet ﬂew is the first Cl⁻ channel current characterized in pancreatic 𝛃 cells. Icl,islet has been hypothesized to modulate insulin secretion through changes in islet electrical activity. Both 5 𝛍M forskolin and 100 𝛍M IBMX (3-isobutyl-1-methylxanthine), agents that increase intracellular cAMP, were shown to activate an outwardly-rectifying ionic current in HIT cells that closely resembled Icl,islet. The current was blocked when iodide was substituted for external Cl⁻ or when

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24

Oddon, Delphine Marie. "Anion channels in the filamentous fungus Aspergillus nidulans : an investigation of the CLC chloride channel family." Thesis, Lancaster University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445459.

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25

Xiang, Yang Sunny. "CFTR chloride channels novel targets for cardioprotection against ischemia and perfusion injury /." abstract and full text PDF (free order & download UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3320885.

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26

Astill, David St John. "Characteristics of baculovirus - expressed in CIC-1 /." Title page, contents and summaryn only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09pha854.pdf.

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27

Li, Xiang. "Using alpha-aminoxy acids as building blocks to construct anion receptors and synthetic chloride channels." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/b4020344x.

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28

Adair, Jeanette. "Alternate channel therapy for the pancreatic disease of Cystic Fibrosis." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251005.

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29

Brookfield, Rebecca. "The pharmacology and cardiovascular function of TMEM16A channels." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-pharmacology-and-cardiovascular-function-of-tmem16a-channels(bdc16466-cecd-4343-9d40-b20bc647d70f).html.

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Calcium-activated chloride channels (CaCCs) are ubiquitously expressed in a plethora of cell types and, consequently, are involved in numerous cellular processes as diverse as epithelial secretion, regulation of cardiac excitability and smooth muscle contraction. Current pharmacology of CaCCs is limited to compounds with low potency and poor selectivity. The lack of knowledge surrounding the molecular identity of the CaCC has greatly hindered the development of more specific drugs and has impaired our understanding of the channel physiology and biophysics. The recent discovery that the TMEM16A

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30

Huang, Zheng. "Molecular physiology of Cl.ir [sic] channels in the heart." abstract and full text PDF (UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3312252.

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31

Li, Xiang, and 李祥. "Using alpha-aminoxy acids as building blocks to construct anion receptors and synthetic chloride channels." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B4020344X.

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The Best PhD Thesis in the Faculties of Dentistry, Engineering, Medicine and Science (University of Hong Kong), Li Ka Shing Prize,2007-2008<br>published_or_final_version<br>Chemistry<br>Doctoral<br>Doctor of Philosophy

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32

Ernest, Nola Jean. "The role of chloride in the volume regulation of human glioma cells." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. http://www.mhsl.uab.edu/dt/2007p/ernest.pdf.

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33

Batthish, Michelle. "Ischemic preconditioning of the myocardium, role of chloride and inward-rectifier potassium channels." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63191.pdf.

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34

Monaghan, Alan S. "Chloride and potassium channels of enterocytes isolated from guinea-pig small intestinal villi." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338067.

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35

Alothaid, Hani M. M. "Characterisation of the pathophysiological role of chloride ion channels in human leukocytes function." Thesis, University of Sheffield, 2019. http://etheses.whiterose.ac.uk/22720/.

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36

Habela, Christa Whelan. "Progression through the cell cycle is regulated by dynamic chloride dependent changes in cell volumes." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/habela.pdf.

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37

Forrester, Sean Geritt. "Characterization of a macrocyclic lactone receptor subunit from Haemonchus contortus." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82872.

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Glutamate-gated chloride channels (GluCls) are the proposed site of action for macrocyclic lactone anthelminthics, such as IVM, and the milbemycins, such as MOX. The objective of this thesis was to determine whether Haemonchus contortus GluCls are important targets for these anthelminthics. To begin to address this we cloned a full length GluCl alpha-subunit cDNA from H. contortus (HcGluCla). This subunit shares a high homology with GluCl subunits from Caenhorhabditis elegans that have been shown to be important targets for IVM, suggesting that HcGluCla is also an IVM target. However, i

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38

Cho, Jeong Han. "Gating of CFTR chloride channels distinct closd states revealed by the action of AMP-PNP /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/5867.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2006.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on August 10, 2007) Vita. Includes bibliographical references.

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39

Chang, Martin Chung-San. "On the regulation and function of potassium and chloride channels in human T lymphocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ45775.pdf.

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40

Smith, S. M. "The properties of agonist-activated chloride channels on rat spinal neurones in cell culture." Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379367.

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41

Fromm, Jan. "Investigating the expression and role of chloride ion channels in diffuse intrinsic pontine glioma." Thesis, Fromm, Jan (2021) Investigating the expression and role of chloride ion channels in diffuse intrinsic pontine glioma. Honours thesis, Murdoch University, 2021. https://researchrepository.murdoch.edu.au/id/eprint/63626/.

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Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive type of glial brain tumour found in the pons region of the brainstem. DIPG accounts for about 10% of childhood central nervous system tumours and the prognosis for these children is poor. Resistance to radiation, the only current available therapy for DIPG, is one of the biggest challenges. This resistance could be due to the plasticity of DIPG cells, allowing them to rapidly adapt in response to different conditions. Preliminary RNA sequencing analyses of patient tumours identified the expression of ion channel genes including the

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42

Ben, Soussia Ismail. "Rôle des canaux chlore volume-sensibles dans la physiologie des fibroblastes: implication dans la physiopathologie vasculaire." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209437.

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Les canaux chlore volume-sensibles (VRACs) régulent les activités différenciatives, migratoires et prolifératives des fibroblastes et pourraient donc être impliqués dans la pathobiologie de l’hypertension artérielle pulmonaire (HTAP) et la fibrose pulmonaire interstitielle (FPI). Diverses études antérieures ont montré que l’endothéline-1 (ET1) a des propriétés pro-fibrosantes, en plus cette molécule participe au remodelage des artérioles pulmonaires dans l’HTAP. D’autre part, ces pathologies d’HTAP et de fibrose pulmonaire peuvent être antagonisées par la mélatonine et par l’interaction entre

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43

Nguyen, Di Kim. "X chromosome upregulation and its biological significance in mammals /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/6326.

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44

Liu, Jie 1970. "Genomic organization and expression of an avermectin receptor subunit from Haemonchus contortus." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80320.

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Avermectins and milbemycins are believed to exert their anthelmintic effects by binding to glutamate-gated chloride channels (GluCls). Two GluCl subunits have been localized in the pharynx in Caenorhabditis elegans , and the pharynx has been implicated as a major target for avermectins in C. elegans. The HcGluCla gene encoding an alpha-type GluCl subunit has been cloned from Haemonchus contortus previously, however the localization of this gene has not been identified. To begin to investigate the expression site of this HcGluCla gene we have isolated a 1439bp 5'-flanking region and the

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45

Pantazis, Antonios. "Characterization of two novel histamine-gated chloride channels from the visual system of Drosophila melanogaster." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614187.

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46

Cilento, Eugene Miler. "Ubiquitin Ligase Trim32 and Chloride-sensitive WNK1 as Regulators of Potassium Channels in the Brain." ScholarWorks @ UVM, 2015. http://scholarworks.uvm.edu/graddis/431.

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The voltage-gated potassium channel Kv1.2 impacts membrane potential and therefore excitability of neurons. Expression of Kv1.2 at the plasma membrane (PM) is critical for channel function, and altering Kv1.2 at the PM is one way to affect membrane excitability. Such is the case in the cerebellum, a portion of the brain with dense Kv1.2 expression, where modulation of Kv1.2 at the PM can impact electrical activity of neurons and ultimately cerebellum-dependent learning. Modulation of Kv1.2 at the PM can occur through endocytic trafficking of the channel; however mechanisms behind this process

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47

Sharma, Aarushi. "HUMAN CLCA2 MODULATES THE CONDUCTANCE OF CALCIUM-ACTIVATED CHLORIDE CHANNELS BY REGULATION OF INTRACELLULAR CALCIUM." OpenSIUC, 2016. https://opensiuc.lib.siu.edu/dissertations/1252.

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Chloride channels play an essential role in the physiology of the respiratory system, the gastrointestinal tract, and secretory glands. Their dysregulation underlies debilitating pathologies such as cystic fibrosis, asthma, and certain cancers. The CLCA (Chloride Channel Accessory) gene family is thought to determine severity of these diseases by modulating an unidentified Calcium-activated Chloride Channel (CaCC). Recent evidence indicates Ano1 to be the mediator of strong quintessential calcium-activated chloride current in several cell types. Ano1 is highly expressed in airway epithelium an

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48

Yang, Cui, and 杨淬. "Roles of prostaglandin E2 receptors and chloride channels in epoxyeicosatrienoic acids-induced relaxation in rat mesentericarteries." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45140273.

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49

O'Driscoll, Kate E. "Molecular and functional expression of the murine Bestrophin family from cardiovascular tissues." abstract and full text PDF (free order & download UNR users only), 2007. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3289453.

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50

Pellegrino, Mark. "Association between GLC-4 and AVR-14 : role of GluCl subunit composition in Caenorhabditis elegans ivermectin sensitivity and behaviour." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79110.

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The glutamate-gated chloride (GluCl) channel family of receptors are members of the ligand-gated ion channel (LGIC) family. In addition to being essential for physiological and behavioural aspects of an organism, they are also exploited as a target for the drug ivermectin. A novel GluCl subunit in C. elegans, GLC-4, was characterized in order to further understand the diversity of GluCls and their implications in biological and behavioural processes. Sequencing of cDNAs generated by RT-PCR indicate that GLC-4 possesses the typical features of a GluCl subunit. In addition, they also sugg

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