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Dissertations / Theses on the topic 'Chlorine Organic compounds'

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1

Heidbrink, Jenny. "A Study of the Behavior of Chlorine and Organic Compounds During Combustion in an AFBC System." TopSCHOLAR®, 1996. http://digitalcommons.wku.edu/theses/801.

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The purpose of this study is to understand the behavior of chlorine and the emission of organic compounds during combustion in an atmospheric fluidized bed combustion (AFBC) system. Inefficient, uncontrolled use of coal gives rise to organic emissions which can be detrimental to health. The chlorine in coal may cause corrosion problems during utilization, if its concentration is high enough. The method for collection of the emissions of organic compounds involved the use of a Tenax resin as an absorbent for the organic compounds as they were emitted from the combustor. A combined gas chromatog
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2

Ben, Amor Hedi. "Le bioxyde de chlore dans la filière de production des eaux de consommation : contribution à l'étude de son mécanisme d'action sur les molécules modèles et sur les substances humiques aquatiques." Poitiers, 1988. http://www.theses.fr/1988POIT2314.

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3

DUARTE, CELINA L. "Aplicacao do processo avancado de oxidacao por feixe de eletrons na degradacao de compostos organicos presentes em efluentes industriais." reponame:Repositório Institucional do IPEN, 1999. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10757.

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Made available in DSpace on 2014-10-09T12:43:41Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:09:56Z (GMT). No. of bitstreams: 1 06654.pdf: 9860874 bytes, checksum: a9212efd0462f2603abb2f237d62a703 (MD5)<br>Tese (Doutoramento)<br>IPEN/T<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
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4

Soriano, Junior Roberto. "Avaliação da presença de vapores no solo em antiga área industrial contaminada por hidrocarbonetos : concentrações medidas e simuladas /." Rio Claro : [s.n.], 2009. http://hdl.handle.net/11449/92755.

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Orientador: José Eduardo Zaine<br>Banca: Scandar Gasperazzo Ignatius<br>Banca: Fábio Augusto Gomes Vieira Reis<br>Resumo: A contaminação de solos e água subterrânea por hidrocarbonetos derivados de petróleo tende a liberar vapores que migram da subsuperfície para o ar, expondo, principalmente o ser humano à inalação de compostos que podem oferecer risco a sua saúde. Porém a volatilização destes compostos pode indicar as possíveis fontes de contaminação em subsuperfície. As agências de proteção ambiental, como a EPA (Environmental Protection Agency), nos Estados Unidos, e os órgãos ambientais n
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5

Soriano, Junior Roberto [UNESP]. "Avaliação da presença de vapores no solo em antiga área industrial contaminada por hidrocarbonetos: concentrações medidas e simuladas." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/92755.

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Made available in DSpace on 2014-06-11T19:26:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-06-09Bitstream added on 2014-06-13T19:54:11Z : No. of bitstreams: 1 sorianojunior_r_me_rcla.pdf: 1949675 bytes, checksum: a6d5cc4f07790ee2fa65e002e7a11372 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A contaminação de solos e água subterrânea por hidrocarbonetos derivados de petróleo tende a liberar vapores que migram da subsuperfície para o ar, expondo, principalmente o ser humano à inalação de compostos que podem oferecer risco a sua saúde. Porém a volat
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6

Croué, Jean-Philippe. "Contribution a l'etude de l'oxydation par le chlore et l'ozone d'acides fulviques naturels extraits d'eaux de surface." Poitiers, 1987. http://www.theses.fr/1987POIT2289.

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7

Tue, Bi Balo. "Etude de la synthèse électrochimique de chloro-oléfines par réaction de Wittig-Horner in situ." Rouen, 1988. http://www.theses.fr/1988ROUES025.

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Les composés du titre sont préparés par une réaction d'Horner Emmons entre un dérivé carbonylé (aldéhydes et cétones aliphatiques et aromatiques) et l'anion issu de la réduction électrochimique du o,o-diéthyl trichlorométhyl phosphanate. On propose une méthode de préparation des dichloro- et chlorométhylphosphonates par électrolyse à courant constant sur cathode à feutre de carbone. Le comportement électrochimique des oléfines dichlorées préparées est étudié. On obtient également un époxyphosphonate par réduction électrochimique d'un sel de phosphonium dérivant du trichlorométhylphosphonate
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8

Hammoud, Abdelhay. "Syntheses de pheromones et de molecules isosteres de pheromones d'insectes pour preciser les mecanismes moleculaires de la reconnaissance des signaux chimiques au niveau des recepteurs antennaires." Paris 6, 1988. http://www.theses.fr/1988PA066679.

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9

Tan, Swee Hain. "Organic corrosion inhibitors." Murdoch University, 1991. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20060818.150145.

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The overall aims of this thesis were to conduct a broad survey of possible organic corrosion inhibitors in near-neutral chloride solutions and to elucidate the mechanisms of such action. Altogether, 130 organic compounds were studied as possible corrosion inhibitors for pure iron, mild steel, copper and aluminium in aerated near-neutral (pH = 8.4) solutions containing 500 ppm NaCl and 100 ppm NaHCO,, conditions often encountered in water-based automotive engine coolants. Inhibitor behaviour was investigated using steady-state electrochemical techniques including polarisation curves, Stern-Gear
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10

Rabeony, Haveloma Manese. "Phenomenes de nucleation en phase vapeur : condensation a basse temperature et en presence d'ions." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13012.

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Etude experimentale de la germination homogene de vapeurs organiques a basse temperature a l'aide d'une chambre a diffusion thermique en vue de tester sur le plus grand intervalle possible de temperature la theorie classique de la germination homogene et de confronter les resultats obtenus avec ceux d'autres techniques experimentales. Etude theorique et experimentale de la germination heterogene en presence d'ions : l'etude theorique permet de verifier l'aptitude des differentes theories a prevoir correctement l'influence de l'ion central, puis les predictions sont confrontees aux resultats ex
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11

Saunders, Justin S. "Combined effects of termiticides, volatile organic compounds, and mechanical stress on chlorinated polyvinyl chloride (CPVC)." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0013263.

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12

Elgadi, Abdelaziz. "Nouvelles applications de la réaction de darzens en synthèse." Nancy 1, 1987. http://www.theses.fr/1987NAN10028.

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13

Abd, Allah Zaenab. "Non-thermal atmospheric pressure plasma for remediation of volatile organic compounds." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/nonthermal-atmospheric-pressure-plasma-for-remediation-of-volatile-organic-compounds(2826f483-e29f-402e-93a7-5f73818c4292).html.

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Non-thermal plasma generated in a dielectric barrier packed-bed reactor has been used for the remediation of chlorinated volatile organic compounds. Chlorinated VOCs are important air pollutant gases which affect both the environment and human health. This thesis uses non-thermal plasma generated in single and multiple packed-bed plasma reactors for the decomposition of dichloromethane (CH2Cl2, DCM) and methyl chloride (CH3Cl). The overall aim of this thesis is to optimize the removal efficiency of DCM and CH3Cl in air plasma by investigating the influence of key process parameters. This thesi
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14

Laboue, Blandine. "Preparation de cetones par acylation de composes organomanganeux : extension et amelioration de la methode." Paris 6, 1987. http://www.theses.fr/1987PA066464.

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Preparation des cetones acetyleniques fonctionnelles et de divers alcools tertiaires par acylation des composes organomagnesiens en presence de sels de manganese seuls ou associes a des sels de cuivre
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15

Zhang, Ye. "Development of amide-derived P,O-ligands for Suzuki cross-coupling of aryl chlorides and the asymmetric version /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202005%20ZHANG.

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16

Wiegert, Charline. "Application of two dimensional compound specific carbon-chlorine isotope analyses for degradation monitoring and assessment of organic pollutants in contaminated soil and groundwater." Doctoral thesis, Stockholms universitet, Institutionen för tillämpad miljövetenskap (ITM), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-93923.

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Nearly 250,000 sites with past and present potentially polluting activities need urgent remediation within Europe. Major pollutants include organochlorines (OCls), e.g. chlorinated ethenes (CEs) and hexachlorocyclohexanes (HCHs), mainly used as industrial solvents and pesticides, respectively. Due to improper handling and disposal, OCls contaminants are present in the soil or groundwater surrounding sites, where they have been produced or used. CEs and HCHs can undergo degradation by microorganisms indigenous to the soil or groundwater. Therefore natural attenuation (NA), relying on the in sit
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17

Alami, Mouâd. "Addition conjuguee de composes organomanganeux sur divers composes carbonyles alpha -beta ethyleniques." Paris 6, 1987. http://www.theses.fr/1987PA066232.

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18

García, V. (Verónica). "Reclamation of VOCs, n-butanol and dichloromethane, from sodium chloride containing mixtures by pervaporation:towards efficient use of resources in the chemical industry." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514292644.

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Abstract Volatile Organic Compounds (VOCs) in wastewaters from the chemical industry are of major concern because of their environmental and health impacts. The reclamation of VOCs from wastewaters would not only reduce the hazard to the environment but also contribute to an efficient use of resources. The thesis explores the reclamation of n-butanol and dichloromethane from sodium chloride containing mixtures by pervaporation. Another aim was to gain understanding of mass transport phenomena during the pervaporation of multicomponent systems, and the effect of sodium chloride on the pervapora
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19

Lendar, Maria. "Dégradation atmosphérique d’une série d’alcools, d’esters et de l’hexafluoroisobutène." Thesis, Orléans, 2012. http://www.theses.fr/2012ORLE2042/document.

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Cette thèse présente le devenir atmosphérique de trois alcools saturés CH3(CH2)4OH, CH3CH2CH2CH(OH)CH3 et (C2H5)2CHOH, de trois esters CH3CH2CH2C(O)OC2H5, CH3CH2C(O)OC2H5 et CH3CH2C(O)OCH2CH2CH3 ainsi que d’un HFC insaturé (CF3)2C=CH2 avec OH et Cl. La constante de vitesse de la réaction avec OH de ces composés a été déterminée en fonction de la température (253 – 373 K), en utilisant la technique Photolyse Laser Pulsée couplée à la Fluorescence Induite par Laser (PLP-FIL). La constante de vitesse de la réaction de OH et de Cl avec les alcools, les esters et l’hexafluoroisobutène (HFIB) a été
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20

Denys, Goument Colombe. "Dicétones-1,4 thiosubstituées." Rouen, 1988. http://www.theses.fr/1988ROUES023.

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21

Brodbeck, Claude. "Transitions doubles induites par collisions dans des melanges gazeux comprimes." Paris 6, 1987. http://www.theses.fr/1987PA066285.

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Etude des transitions doubles (simultanees) correspondant a l'absorption d'un seul photon par deux molecules en interaction pour les systemes gazeux comprimes : h::(2) + cf::(4) ou sf::(6), o::(2) ou n::(2) + sf::(6), n::(2) + co::(2). Determination de coefficients d'absorption binaire integres et des profils normalises que l'on compare aux valeurs theoriques calculees en utilisant le moment dipolaire induit et l'intensite de la transition induite en fonction des regles de selection sur les nombres quantiques. Choix des differents parametres caracterisant les deux molecules et leur potentiel d
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22

Chavant, Pierre Yves. "Reaction de type barbier ou reformatsky effectuees a l'aide de manganese." Paris 6, 1988. http://www.theses.fr/1988PA066138.

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Etude de la reactivite du manganese metallique vis-a-vis d'halogenures allyliques et d'halogeno-2 esters. Une etude de l'influence du solvant et de la presence de divers sels metalliques, a debouche sur la mise au point d'une nouvelle voie d'acces a des alcools homoallyliques
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23

Colombano, Stéfan. "Improvement of the recovery of heavy chlorinated organic compounds in saturated porous media by thermal and chemical enhancements : experimental and two-phase flow modeling approaches." Thesis, Paris Est, 2019. http://www.theses.fr/2019PESC2032.

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La pollution des eaux souterraines par des composés organochlorés constitue un problème majeur. En effet, ces polluants, particulièrement toxiques, dégradent durablement les sols et les eaux souterraines. Leur dispersion (par solubilisation et volatilisation) à partir des sources de pollution peut générer des panaches de contamination importants. La récupération de ces composés sous forme de produit pur (DNAPL) est principalement basée sur les techniques de pompage/traitement. Pour autant, cette technique est lente et ne permet pas de récupérer le DNAPL de manière efficace. Une quantité de DNA
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24

Houllemare, Didier. "Allylation de dérivés carbonylés dans l'eau. Synthèse et réactivité de sélénoéthers β-hydroxylés delta-insaturés". Rouen, 1997. http://www.theses.fr/1997ROUES076.

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L'allylation et la propargylation de dérivés carbonylés par l'étain dans l'eau sont étudiées. L'ajout d'iodure de potassium autorise l'utilisation de dérivés chlorés allyliques de structures variées, connus pour leur très faible réactivité. Nous montrons que la substitution halogénure-iodure s'effectue dans l'eau avant réaction. L'étude de l'allylation par le système chlorure stanneux/iodure de potassium, dans le même solvant, nous a permis de déterminer les meilleures conditions expérimentales. Seuls les aldéhydes sont réactifs. Les dérivés chlorés dans ces conditions sont aussi utilisables.
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25

Ngono, Bernadette. "Organométalliques à carbonyle masqué : quelques propriétés du lithio-1 triméthylsiloxy-2 éthylène." Rouen, 1989. http://www.theses.fr/1989ROUES021.

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La condensation du lithio-1 triméthylsiloxy-2 éthylène avec les chlorotrialkylsilanes et le triflate de t-butyldiméthylsilyle conduit aux éthers d'énols silyles -silyles. L'hydrolyse acide de ces derniers permet d'isoler le t-butyldiméthylsilyl acétaldéhyde. D'autre part, la condensation du lithio-1 triméthylsiloxy-2 éthylène avec les chlorures d'acides non énolisables conduit a des esters d'énols de -cétoaldéhydes
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26

Milton, Edward J. "Pd catalysed C-C & C-O bond formation using bis-(dialkyl/diarylphosphino)ferrocene ligands." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/1022.

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A brief introduction explaining phosphine ligand properties, Pd catalysed cross-coupling reactions; the importance of the steps involved in the catalytic cycle (oxidative addition, transmetalation & reductive elimination), mechanistic studies and a comparison of various reactions will give an overview of important cross-coupling reactions and their limitations. The development of a “super-concentrated” (5M) Pd catalysed Kumada type coupling reaction has been developed for coupling a range of aryl bromide and chloride substrates with the Grignard reagents ((p-CF₃-C₆H₄)MgBr)) and PhMgBr in methy
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27

Zhou, Jian Sheng. "Correlation entre tension interfaciale et composition de la couche adsorbee de systemes diphasiques capable de donner des microemulsions : influence de l'alcool comme cotensioactif." Paris 6, 1987. http://www.theses.fr/1987PA066674.

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La composition de la couche adsorbee a l'interface de systemes diphasiques : eau+nacl; dodecane, dodecylsulfate de sodium ou dodecylbenzenesulfonate comme agent de surface et butanol, pentanol ou alcool benzylique comme coagent de surface, est determinee par application de la loi de gibbs
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28

Liu, Huaqin. "Etude de l'oligomérisation des alpha-oléfines amorcées par des systèmes bimétalliques à base de dérivés d'un métal de transition (groupe IV B) et de composés organoaluminiques." Paris 6, 1986. http://www.theses.fr/1986PA066087.

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29

Therrien, Annamarie F. "Degradation of Chlorinated Hydrocarbons in Groundwater Passing Through the Treatment Wetland at Wright-Patterson Air Force Base: Analysis of Results Collected During 2001-'06." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1363477561.

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30

Loret, Jean-François. "Extraction de metaux precieux par des gels organiques." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13068.

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Preparation de gels qui sont des polymeres reticules qui gonflent lorsqu'ils sont plonges dans des solvants adequats. Le gel pvc-tbp est utilise pour extraire l'or en milieu hcl : les ions m(cn)::(2)**(-) (m=ag,au) en milieu koh sont extraits par le gel dcy-18c6-chcl::(3)-br (br = polylentadiene)
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31

RIFI, EL HOUSSEINE. "Extraction metallique par des gels hydrophobes." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13158.

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Etude de l'extraction liquide-gel de cu, v et eu. On montre que les lois de la thermodynamique d'extraction de cu par les acyl-4 pyrazolones-5 ne sont pas pertubees par la presence du polymere, mais que la cinetique l'est fortement. L'impregnation des polybutadienes par la trilamylamine presente des difficultes; l'utilisation de pvc gonfle dans des solutions d'oxyde d'octylphenyl n,n-diisobutylcarbamoylmethylphosphine dans tbp est interessante
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32

Talbaoui, Ahmed. "Etude en microscopie électronique par cryofracture des systèmes chlorures et bromure de dodécylamine-eau." Rouen, 1989. http://www.theses.fr/1989ROUES006.

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Après une importante bibliographie concernant les phases lyotropes et les techniques cryogéniques en microscopie électronique, l'auteur expose les résultats de ses observations en cryofracture sur les systèmes du titre. Description de la transition lamellaire-nématique et comparaison aux modèles présentés par d'autres auteurs. Discussion de la validité de la technique de cryofracture pour ce type de systèmes
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33

Francese, Catherine. "Reactions du bromotrifluoromethane en presence de zinc : trifluoromethylations dans les conditions de barbier." Paris 6, 1987. http://www.theses.fr/1987PA066381.

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34

Bedioui, Fethi. "Etude électrochimique de complexes de métaux de transition (bases de Schiff et porphyrines) en solution et sous forme d'électrodes modifiées : application à la catalyse électroassistée de réactions organiques." Paris 6, 1986. http://www.theses.fr/1986PA066338.

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Les propriétés électrochimiques des complexes co-base de Schiff (phenylene-bis(salicylideneiminoto)-co, ou Co(II)saloph, et n-methylenepropylene-bis-(salicylideneiminoto)-co, ou co-selnmedpt) et de tetraphenylporphine-co, ou CoTPP, sont utilisées pour étudier la réduction électroassistée d'halogénures organiques, Rx, avec un catalyseur fixe sur support conducteur, en milieu organique. On étudie: 1) la réduction du chlorure de benzyle électrocatalysée par des électrodes de graphite modifiées par du co-saloph et 2) l'oxydation par l'oxygène moléculaire du di-tert-butylphenol, électrocatalysée pa
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35

Hsieh, Shui-Chuan, and 謝瑞全. "Clays catalyzed the reactions between the organic compounds in water and disinfectants (chlorine)." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/60904566955536763346.

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碩士<br>國立中央大學<br>環境工程研究所<br>90<br>To study disinfection by-products formation potential (DBPFP) in water purification system, dissolving organic compounds (DOCs) including humic acid and fulvic acid have recently gained added importance because of the need to determine DOCs reactivity with disinfecting agents. In addition to DOCs, turbility matter is the other important factor to affect the DBPs formation. In this study, the influences of surface characteristics of clays on organic compounds chlorination in drinking water purification processes were investigated. The characteristics of organic
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36

Nihemaiti, Maolida. "Formation of emerging DBPs from the chlorination and chloramination of seawater algal organic matter and related model compounds." Thesis, 2014. http://hdl.handle.net/10754/316699.

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Limited studies focused on reactions occurring during disinfection and oxidation processes of seawater. The aim of this work was to investigate disinfection by-products (DBPs) formation from the chlorination and chloramination of seawater algal organic matter and related model compounds. Simulated algal blooms directly growing in Red Sea, red tide samples collected during an algal bloom event and Hymenomonas sp. monoculture were studied as algal organic matter sources. Experiments were conducted in synthetic seawater containing bromide ion. A variety of DBPs was formed from the chlorination an
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37

Hu, Cheng. "Modeling reaction kinetics of chlorine dioxide and volatile organic compounds with artificial neural networks." 2003. http://purl.galileo.usg.edu/uga%5Fetd/hu%5Fcheng%5F200312%5Fms.

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38

Leusen, Frank J. J. "Crystal Structure Prediction of Diastereomeric Salts: A Step toward Rationalization of Racemate Resolution." 2003. http://hdl.handle.net/10454/3555.

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No<br>Crystal structure prediction simulations were carried out to explore the solid state packing alternatives of two diastereomeric salts consisting of a chlorine-substituted cyclic phosphoric acid and the two enantiomers of ephedrine. The experimentally observed crystal structures were correctly simulated with an error of a few kcal/mol. This represents a significant achievement in crystal structure prediction due to the complexity of the mathematical search problem at hand (two distinct molecules in the asymmetric unit, one of which is flexible) and due to the complex energetics of these o
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39

Hei, Cheng-Ming, and 黑正明. "Characteristics of Destruction of Airborne Chlorine- and Nitrogen-Containing Volatile Organic Compounds (VOCs) by Regenerative Thermal Oxidizers." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/43647110435114317366.

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博士<br>國立中山大學<br>環境工程研究所<br>95<br>In this study, two regenerative thermal oxidizers (RTO) were used to test the thermal destruction, thermal recovery efficiency and the gas pressure drop over the beds characteristics when burning, respectively, airborne chlorine- and nitrogen-containing volatile organic compounds (VOCs). First, an electrically-heated RTO containing two 0.5 m × 0.5 m × 2.0 m (L × W × H) beds, both packed with gravel particles with an average diameter of around 0.0116 m and a height of up to 1.48 m with a void fraction of 0.41 in the packed section was used to study the destructi
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40

Pors, Klaus, Z. Paniwnyk, Laurence H. Patterson, K. C. Ruparelia, J. A. Hartley, and L. R. Kelland. "Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor cells." 2004. http://hdl.handle.net/10454/3164.

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No<br>Novel 1- and 1,4-substituted chloroethylaminoanthraquinones with DNA binding and alkylating properties along with their respective hydroxyethylaminoanthraquinone intermediates were synthesized. Selected chloroethylaminoanthraquinones were shown to cross-link DNA and alkylate guanines (at low nM concentration) with a preference for reaction sites containing 5'-PyG. A compound (Alchemix) with the bis-chloroethyl functionality confined to one side chain alkylated but did not cross-link DNA. All the 1,4-disubstituted chloroethylaminoanthraquinones were potently cytotoxic (nM IC50s) against c
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41

Fang, Tian Zhi, and 方天志. "the effect of organic and inorganic chloride on the formation of CO, HCI and organic compounds during incineration process." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/72170196249058575904.

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42

Marks, Alison J. "Nonadiabatic transition-state theory: A Monte Carlo Study of competing bond fission processes in bromoacetyl chloride." 2001. http://hdl.handle.net/10454/4107.

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No<br>Nonadiabatic Monte Carlo transition-state theory is used to explore competing C¿Cl and C¿Br bond fission processes in a simple model of 1[n,pi*(CO)] photoexcited bromoacetyl chloride. Morse potentials are used to represent bond stretching coordinates, and the positions and magnitudes of nonadiabatic coupling between excited state potentials are modeled using ab initio data. The main effect of nonadiabaticity is to favor C¿Cl fission over C¿Br, despite a larger barrier to C¿Cl dissociation. The absolute values of the rate constants are smaller than observed experimentally, but the calcula
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Teesdale-Spittle, P. H., Klaus Pors, R. Brown, Laurence H. Patterson, and J. A. Plumb. "Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells." 2005. http://hdl.handle.net/10454/3191.

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Abstract:
No<br>A novel series of 1,4-disubstituted aminoanthraquinones were prepared by ipso-displacement of 1,4-difluoro-5,8-dihydroxyanthraquinones by hydroxylated piperidinyl- or pyrrolidinylalkyl-amino side chains. One aminoanthraquinone (13) was further derivatized to a chloropropyl-amino analogue by treatment with triphenylphosphine-carbon tetrachloride. The compounds were evaluated in the A2780 ovarian cancer cell line and its cisplatin-resistant variants (A2780/ cp70 and A2780/MCP1). The novel anthraquinones were shown to possess up to 5-fold increased potency against the cisplatin-resistant ce
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