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Journal articles on the topic 'CHLORO DERIVATIVES'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Drašar, Pavel, and Jiří Beránek. "2',3'-O-Carbonyl derivatives of 6-azauridine in the synthesis of its 5-substituted and 5'-deoxy derivatives." Collection of Czechoslovak Chemical Communications 52, no. 8 (1987): 2070–82. http://dx.doi.org/10.1135/cccc19872070.

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Preparation of 2',3'-O-carbonyl derivatives of 5'-deoxy-6-azauridine and 6-azauridine using 1,1'-carbonyldiimidazole has been elaborated. 5'-Chloro and 5'-bromo derivatives were prepared by treatment of the 5'-O-mesyl derivative with quaternary ammonium halides, 5'-chloro derivatives also by direct halogenation with thionyl chloride in hexamethylphosphortriamide or with tetrachloromethane, triphenyl phosphine, and dimethylformamide. Derivatives of 5'-bromo-6-azauridine were reduced with tributyltin hydride to 5'-deoxy-6-azauridine compounds. 6-Azauridine 2',3'-carbonate (IVa) and its 5'-deriva

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2

K. Abdullah, Ebtihal. "Synthesis of New (1-alkylamino-4-phenyldithio-2-bntanol amine) andderivatives." Tikrit Journal of Pharmaceutical Sciences 6, no. 1 (2023): 78–82. http://dx.doi.org/10.25130/tjphs.2010.6.1.12.78.82.

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Anew series of(1-alkylamino-4-phenyldithio-2-bntanol amine) and derivatives,containing two functional groups (pheny ring and NCS2) here been prepared from a reaction by 3steps :- 1-In the first step the preparation of n-phenyl dithio carbamate (A) and derivatives from a reaction between Aniline and carbon disulfide in basic medium. 2-Then , preparation N-3-chloro-2-hydroxy propyl amine tt 3 )) and derivativel from reaction between N-3-chloro-2-hydroxy propylamine and epichloro hydrine in methanolic a queous.3-In three step :-preparation 1-Alkyi amino -4-phenyl dithio-2-butanol amine ( I-IV) fr

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3

Knörzer, Gabriele, Hermann Seyffer, Hans Pritzkow, and Walter Siebert. "Neuartige Allylboran- und Allyldiboran(4)-Derivate / Novel Allylboran- and Allyldiboran(4) Derivatives." Zeitschrift für Naturforschung B 45, no. 7 (1990): 985–88. http://dx.doi.org/10.1515/znb-1990-0712.

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Allyldiboran(4) derivatives la—c are obtained from allylmagnesium chloride and chloro derivatives of diboran(4). la—c are air-sensitive liquids; heating of le did not yield a 2,3-dihydro-l,2-diborole derivative (B). Reaction between 1,1-bis(dichloroboryl)-3,3-dimethyl-butane (5) and H2C=C(CH2SnMe3)2 (4) leads to the heat-sensitive chloro derivative 2a, in which the chlorine is substituted by Me3SiNMe2 to give stable 1,3-bis-dimethylamino-5-methylene-2-neopentyl- 1,3-diborinane (2 b). 1,2-Bis(dichloroboryl)benzene and 4 yield the chloro derivative 3a, and its substitution with HN(i-Pr)2 leads t

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4

Neamah, Rawaa, та Shaimaa Adnan. "Study the Biological Activity for Shiff Base and Β – Lactam Compounds that Synthesis and Identification from Pyrimidine Derivatives". International Journal of Pharmaceutical Quality Assurance 11, № 01 (2013): 37–39. http://dx.doi.org/10.25258/ijpqa.11.1.12.

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In This study We are synthesis and characterization of some Schiff base and β- lactam derivatives) by three steps. The First react 2-amino-4-Chloro-6-methyl pyrimidine with 4-amino acetophenone in an acid medium to get shiff base derivative(E)-4-(1-((4-Chloro-6-methyl pyridine-2-yl)imino)ethyl)aniline (1), the second step (1) react with (3,4- dimethoxybenzal dehyde,4-methyl benzaldehyde,4-dimethylamino benzaldehyde,4-bromo benzaldehyde,4–hydroxy benzaldehyde, 4-Nitro benzaldehyde) to get Schiff base derivatives (2-7), the last step (2-7) derivatives react with Chloro acetyl chloride to get –β-

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5

Krečmerová, Marcela, Hubert Hřebabecký, and Antonín Holý. "Synthesis of 5-Phenylcytosine Nucleoside Derivatives." Collection of Czechoslovak Chemical Communications 61, no. 4 (1996): 645–55. http://dx.doi.org/10.1135/cccc19960645.

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Reaction of silylated 5-phenylcytosine with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribose, catalyzed with tin tetrachloride, and subsequent methanolysis afforded 5-phenylcytidine (2). This compound reacted with thionyl chloride in acetonitrile to give cyclic sulfite 3 which on heating in dimethylformamide was converted into 2,2'-anhydro-1-(β-D-arabinofuranosyl)-5-phenylcytosine (4). Analogous reaction of compound 2 with thionyl chloride at reflux gave 5'-chloro-5'-deoxy-2',3'-cyclic sulfite 5. Its heating in dimethylformamide afforded 5'-chloro-2,2'-anhydro derivative 6, mild alkaline hydrolysis led

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6

Dillip, Kumar Ojha, N. Prasad R., Rao Hitesh, Gupta Yogesh, Agrawal Umesh, and Chand Pooran. "Adenosine receptors. Part 1 : (2S,3S,4R,5R)-2-(4-(alkyl/arylamino)-5Hpyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol derivatives as possible adenosine receptor agonists." Journal of Indian Chemical Society Vol. 91, Aug 2014 (2014): 1451–57. https://doi.org/10.5281/zenodo.5728670.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India Therachem Research Medilab (Ind) Pvt. Ltd., E 969, Biotechnology Park, Sitapura Industrial Area, Jaipur-302 022, Rajasthan, India <em>E-mail</em> : ojha79@gmail.com, pchand@therachemlab.com, rnp_1949@yahoo.co.in <em>Manuscript received 19 January 2014, accepted 01 February 2014</em> 6-Substitued adenosine derivatives are well known adenosine receptor agonists and a few of these derivatives are being used as therapeutic agents. A series of novel N<sup>6</sup> -substituted-9-deaza adenosine or N<sup>4</sup> -subst

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7

Horáčková, Jaroslava, and Vojeslav Štěrba. "Coupling Kinetics of Benzenediazonium Ions with 2,6-Dioxo-3-(p-substituted phenylhydrazono)-1,2,3,6-tetrahydropyridine-4-carboxylic Acid." Collection of Czechoslovak Chemical Communications 57, no. 9 (1992): 1915–27. http://dx.doi.org/10.1135/cccc19921915.

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The kinetics have been measured of the reactions of 4-nitro-, 4-chloro-, and 4-methoxybenzenediazonium ions with substituted phenylazo derivatives of citrazinic acid in buffer solutions, and the pKa values of the corresponding monoazo and bisazo compounds have been estimated. The reactions of 4-nitrobenzenediazonium ion with 4-chloro- and 4-methoxyphenylazo derivatives and of 4-chlorobenzenediazonium ion with 4-methoxyphenylazo derivative were accompanied by a partial replacement of the substituted phenylazo group by the 4-nitro- and 4-chlorophenylazo groups, respectively. The reactions of 4-c

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8

More, Paresh S., and Santosh G. Singh. "Synthesis and Characterization of Ester Derivatives of Stilbene Derived from Acid Derivative (of P-Chloro Phenyl Acetic Acid, Substitute Benzaldehyde, Triethyl Amine) with Methanol and Sulphuric Acid." International Letters of Chemistry, Physics and Astronomy 47 (February 2015): 49–55. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.47.49.

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Two stilbene derivatives have been synthesized in two step process. First step involved synthesis of acid derivative from p-chloro phenyl acetic acid, substituted benzaldehyde and triethyl amine, where as the second step involved synthesis of substituted stilbene derivatives (enoate or esters) through very simple route. These derivatives were characterized by various spectral techniques and were screened for their antimicrobial activities.

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9

More, Paresh S., and Santosh G. Singh. "Synthesis and Characterization of Ester Derivatives of Stilbene Derived from Acid Derivative (of P-Chloro Phenyl Acetic Acid, Substitute Benzaldehyde, Triethyl Amine) with Methanol and Sulphuric Acid." International Letters of Chemistry, Physics and Astronomy 47 (February 24, 2015): 49–55. http://dx.doi.org/10.56431/p-7bsx45.

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Two stilbene derivatives have been synthesized in two step process. First step involved synthesis of acid derivative from p-chloro phenyl acetic acid, substituted benzaldehyde and triethyl amine, where as the second step involved synthesis of substituted stilbene derivatives (enoate or esters) through very simple route. These derivatives were characterized by various spectral techniques and were screened for their antimicrobial activities.

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10

Rádl, Stanislav, and Lenka Kovářová. "Some reactions of N-propadienyl-4-quinolones." Collection of Czechoslovak Chemical Communications 56, no. 11 (1991): 2413–19. http://dx.doi.org/10.1135/cccc19912413.

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N-Alkylation of ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (Vg) with 3-bromopropyne followed by acidic hydrolysis provided N-propyl derivative Ic which in alkaline media yielded N-propadienyl derivative IId. Propadienyl derivatives IIa and IIb treated with primary or secondary amines provided intermediates IIIa-IIIc which were hydrolyzed to N-acetonyl derivatives IVa and IVb, respectively. N-Benzylation of ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (Va) followed by hydrolysis yielded 1-benzyl-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic ac

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11

Sabzi, Noor Ali Hussein, and May Mohammed Jawad Al-Mudhafar. "Synthesis, characterization, and antimicrobial evaluation of new Schiff bases derived from vanillic acid conjugated to heterocyclic 4H-1,2,4-triazole-3-thiol." Pharmacia 70, no. 3 (2023): 657–63. http://dx.doi.org/10.3897/pharmacia.70.e104579.

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A multistep synthesis was established for the preparation of a new vanillic acid-1, 2, 4-1triazole-3-thiol conjugate (4). Finally, several aromatized aldehydes reacted with compound (4) to produce Schiff bases derivatives (5–11). The purpose of this research is to prepare new vanillic acid derivatives with 1, 2, 4-triazole-3-thiol heterocyclic ring structures and to evaluate their antimicrobial activity in a preliminary assessment. Fourier-transform infrared (FT-IR) and proton nuclear magnetic resonance spectroscopy (1H-NMR) were used to verify the structures of the newly synthesized compounds

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12

Benameur, Ahmed, Taoues Boumoud, Boudjemaa Boumoud, and Salah Rhouati. "A Convenient Access to Biquinoline Carbaldehydes using Nickel-Phosphine Complex-Mediated Homocoupling of Haloquinoline Carbaldehydes in One-Pot Reaction." E-Journal of Chemistry 7, no. 4 (2010): 1196–99. http://dx.doi.org/10.1155/2010/782913.

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The homocoupling of 2-chloro-carbaldehyde derivatives gave the corresponding 2,2’-biquinolines by using thein situgenerated reactive reagent Ni[(PPh3)]4. Several new 2-chloro-3-(1.3 dioxalan-2yl) quinoline derivatives are synthesized and structurally characterized. The overall structures of biquinoline derivatives are not planar.

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13

Dědek, Václav, and Ivan Hemer. "Photochemical chlorotrifluoroethylation of 1,2-, 1,3-, and 1,4-diols." Collection of Czechoslovak Chemical Communications 50, no. 12 (1985): 2743–52. http://dx.doi.org/10.1135/cccc19852743.

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The UV light-initiated reaction of chlorotrifluoroethylene with 1,2-ethanediol (I) proceeds only in the presence of acetone and affords 2-(2-chloro-1,1,2-trifluoroethyl)-2-methyl-1,3-dioxolane (VI). It has been proved that I is first photolyzed to acetaldehyde. Its acetalization in the reaction mixture gives 2-methyl-1,3-dioxolane (V) which then undergoes chlorotrifluoroethylation. The chlorotrifluoro derivative of 1,2-ethanediol XII was prepared by hydrolysis of 4-(2-chloro-1,1,2-trifluoroethyl)-2,2-dimethyl-1,3-dioxolane (XIII). 1,3-Propanediol (II) reacted to give 5-chloro-4,4,5-trifluoro-1

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14

Tudose, Madalina, Florin Badea, Miron Caproiu, et al. "New N-aryloxy-phthalimide derivatives. Synthesis, physico-chemical properties, and QSPR studies." Open Chemistry 8, no. 4 (2010): 789–96. http://dx.doi.org/10.2478/s11532-010-0063-6.

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AbstractStarting from N-hydroxyphthalimide 1 and the reactive fluoro- or chloro-nitroaryl derivatives 2, 3 and 4a-e (2-chloro-3,5-dinitropyridine; 3, NBD-chloride; 4a, 1-fluoro-2,4-dinitrobenzene; 4b, picryl chloride; 4c, 4-chloro-3,5-dinitrobenzotrifluoride; 4d, 2-chloro-3,5- dinitrobenzotrifluoride; 4e, 4-chloro-3,5-dinitrobenzoic acid) the corresponding N-(2-nitroaryloxy)-phthalimide derivatives 5a-e, or 6 and 7 were obtained and characterized by IR, UV-Vis 1H-NMR and 13C-NMR spectroscopy. The TLC behavior and the hydrophobicity of these derivatives have been experimentally evaluated by RM0

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15

Callebaut, Gert, Sven Mangelinckx, Pieter Van der Veken, Karl W. Törnroos, Koen Augustyns та Norbert De Kimpe. "Asymmetric synthesis of γ-chloro-α,β-diamino- and β,γ-aziridino-α-aminoacylpyrrolidines and -piperidines via stereoselective Mannich-type additions of N-(diphenylmethylene)glycinamides across α-chloro-N-sulfinylimines". Beilstein Journal of Organic Chemistry 8 (5 грудня 2012): 2124–31. http://dx.doi.org/10.3762/bjoc.8.239.

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The asymmetric synthesis of new chiral γ-chloro-α,β-diaminocarboxylamide derivatives by highly diastereoselective Mannich-type reactions of N-(diphenylmethylene)glycinamides across chiral α-chloro-N-p-toluenesulfinylaldimines was developed. The resulting (S S,2S,3S)-γ-chloro-α,β-diaminocarboxylamides were formed with the opposite enantiotopic face selectivity as compared to the (S S,2R,3R)-γ-chloro-α,β-diaminocarboxyl esters obtained via Mannich-type addition of analogous N-(diphenylmethylene)glycine esters across a chiral α-chloro-N-p-toluenesulfinylaldimine. Selective deprotection under diff

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16

Sabzi, Noor Ali Hussein, and May Mohammed Jawad Al-Mudhafar. "Synthesis, characterization, and antimicrobial evaluation of new Schiff bases derived from vanillic acid conjugated to heterocyclic 4H-1,2,4-triazole-3-thiol." Pharmacia 70, no. (3) (2023): 657–63. https://doi.org/10.3897/pharmacia.70.e104579.

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A multistep synthesis was established for the preparation of a new vanillic acid-1, 2, 4-1triazole-3-thiol conjugate (4). Finally, several aromatized aldehydes reacted with compound (4) to produce Schiff bases derivatives (5–11). The purpose of this research is to prepare new vanillic acid derivatives with 1, 2, 4-triazole-3-thiol heterocyclic ring structures and to evaluate their antimicrobial activity in a preliminary assessment. Fourier-transform infrared (FT-IR) and proton nuclear magnetic resonance spectroscopy (<sup>1</sup>H-NMR) were used to verify the structures of the newly synthesize

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17

S., Ganguly, P. Singh S., and Chandra R. "Synthesis and antimicrobial activity of some new 2-methyl-5-nitroimidazole derivatives." Journal of India Chemical Society Vol 81, Sep 2004 (2004): 781–82. https://doi.org/10.5281/zenodo.5833148.

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Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835 215, India <em>E-mail</em>: pompil23@rediffmail.com <em>Manuscript received 29 September 2003. revised 15 March 2004, accepted 6 April 2004</em> Amines and phenoxy derivatives of 1-(3'-chlorn-2'-hydroxypropyl)-2-methyl-5-nitroimidazole were synthesized by reacting 1-(3' -chloro-2' -hydroxypropyl)-2-mcthyl-5-nitroimidazole with appropriate amines and phenols. These compounds were characterized by spectral and elemental analyses. All the compounds were screened for their antimicrobial act

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18

Rajni Swamy, V., P. Gunasekaran, R. V. Krishnakumar, N. Srinivasan, and P. Müller. "Crystal structure of [4-(2-methoxyphenyl)-3-methyl-1-phenyl-6-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-5-yl](thiophen-2-yl)methanone." Acta Crystallographica Section E Structure Reports Online 70, no. 9 (2014): o974—o975. http://dx.doi.org/10.1107/s1600536814017437.

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The title compound, C26H18F3N3O2S, a 2-methoxy-substituted derivative, is closely related to its 4-methyl- and 4-chloro-substituted analogues and yet displays no structural relationships with them. The thiophene ring is disorder free and the –CF3group exhibits disorder, respectively, in contrast and similar to that observed in the 4-methyl- and 4-chloro-substituted derivatives. The torsion angle which defines the twist of the thiophene ring is −69.6 (2)° (gauche) in the title compound, whereas it is anticlinal in the 4-methyl- and 4-chloro-substituted derivatives, with respective values of 99.

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19

Šindelář, Karel, Vladimír Valenta, Jiří Holubek, Oluše Matoušová, and Miroslav Protiva. "Potential antidepressants. Synthesis of 6,11-dihydrodibenzo[b,e]thiepin-11-yl (dimethylaminomethyl)phenyl ethers, sulfides, amines and some related compounds." Collection of Czechoslovak Chemical Communications 55, no. 1 (1990): 282–95. http://dx.doi.org/10.1135/cccc19900282.

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Reactions of 11-chloro-6,11-dihydrodibenzo[b,e]thiepin and its 2-bromo derivative with the isomeric (dimethylaminomethyl)phenols, (dimethylaminomethyl)thiophenols, and (dimethylaminomethyl)anilines in toluene afforded the title compounds IIIb,c, Va, VIIIa,b,c, and Xa,b,c. Reactions of 11-chloro-6,11-dihydrodibenzo[b,e]thiepin and its 2-chloro and 2-methyl derivatives with N,N-dimethyl-2-(4-aminophenoxy)ethylamine and N,N-dimethyl-3-(4-aminophenoxy)propylamine by heating in dimethylformamide in the presence of sodium carbonate gave the diamino ethers XI-XIV. The compounds showed only indication

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20

Adnan, Shaimaa, and Abdullah Shakir. "Synthesis and Characterization of some new Formazan Derivatives from 2-Amino-4-Hydroxy-6-Methyl Pyrimidine and Study the Biological Activity (Anti-Bacteria and Anti-Cancer)." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 11, no. 01 (2020): 53–59. http://dx.doi.org/10.25258/ijpqa.11.1.8.

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This study involves a synthesis of some formazan derivatives starting from react chloro acetyl chlorid with 2-amino-4-hydroxy-6-methyl pyrimidine to gate compound (a), (a) react with hydrazine hydrate to give compound (b) also (b) react with 3-4-dimethoxy benzaldehyd to product Schiff base derivative (c) then (c) react with deferent amin derivatives to get formazan derivatives. All these compounds characterized by 13C-NMR, fourier transform infrared spectroscopy (FTIR), 1HMNR. After that, we study the biological activity for all formazan derivatives toward two different kinds of bacteria and a

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21

Di Santo, R., R. Costi, M. Artico, et al. "1,2,5-Benzothiadiazepine and Pyrrolo[2,1-d]-[1,2,5]Benzothiadiazepine Derivatives with Specific Anti-Human Immunodeficiency Virus Type 1 Activity." Antiviral Chemistry and Chemotherapy 9, no. 2 (1998): 127–37. http://dx.doi.org/10.1177/095632029800900204.

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We synthesized and tested as novel inhibitors of human immunodeficiency virus type 1 (HIV-1) bi- and tricyclic thiadiazine ring homologues of 7-chloro-2-ethyl-2 H-1,2,4-benzothiadiazin-3-(4 H)-one 1,1-dioxide, which is a compound endowed with anti-HIV-1 activity at low micromolar concentrations. Benzothiadiazepine derivatives were obtained by alkylation of 8-chloro-2,3-dihydro-3-methyl-1,2,5-benzothiadiazepin-4(5 H)-one 1,1-dioxide, which was obtained by intramolecular cyclization of 2-(2-amino-5-chloro-benzenesulphonamido) propanoic acid. Pyrrolobenzothiadiazepines were synthesized from N-sub

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22

Ukirde, R. D., R. B. Patil, and S. D. Sawant. "Design, Synthesis and Evaluation of Antioxidant Activity of Some Coumarin Derivatives." Asian Journal of Organic & Medicinal Chemistry 4, no. 3 (2019): 138–43. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p172.

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Coumarin derivatives are an important class of heterocyclic compounds, specifically 4-amino substituted coumarins with antioxidant, anticancer activities. The above observations prompted us to synthesize new coumarins with various substitutions. The starting material 4-chloro-2H-chromen-2-one was synthesized by refluxing a mixture of 4-hydroxy-2H-chromen-2-one in phosphoryl chloride. The 4-substituted amine derivatives of coumarin were synthesized by refluxing 4-chloro-2H-chromen-2- one with 4-substituted amines and anhydrous K2CO3 and methanol. All the eleven 4-substituted amine derivatives o

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23

Vasuki, B., N. Mahadevan, V. Sekar, M. Vijayabaskaran, and V. Senthil. "Synthesis and cytotoxicity of Mannich Base of Benzimidazole Derivatives against Neuroblastoma Cell line." Research Journal of Chemistry and Environment 27, no. 4 (2023): 113–19. http://dx.doi.org/10.25303/2704rjce1130119.

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The present study is to synthesize a novel Mannich base of benzimidazole derivatives and to screen for cytotoxicity in a neuroblastoma cell line using the MTT assay. 2-phenyl benzimidazole, formaldehyde, adamantine 1-carboxylicacid and substituted benzylamine such as 4-methyl, 4-methoxy, 4-chloro, 2-chloro, 4-fluoro, 3-methoxy, 4-trifluoromethyl, 3,4-dichloro and 3,5 bistrifluoromethyl were used to synthesize Mannich bases of (3r, 5r, 7r)-N-Benzyl-N-((2-phenyl-1H-benzo[d]imidazol-1-yl) methyl) adamantane-1-carboxamide. The MTT cell viability assay was performed to determine the half maximal in

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24

Olszewska, E., B. Tarasiuk, and S. Pikus. "New powder diffraction data of some N-derivatives of 4-chloro-3,5-dimethylphenoxyacetamide-potential pesticides." Powder Diffraction 26, no. 4 (2011): 337–45. http://dx.doi.org/10.1154/1.3652921.

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N-derivatives of 4-chloro-3,5-dimethylphenoxyacetamide—2-(4-chloro-3,5-dimethylphenoxy)-N-(4-fluorophenyl)acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-(3-chloro-4-fluorophenyl) acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-[4-chloro-3-(trifluoromethyl)phenyl] acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-[3-chloro-4-methylphenyl]acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-(2,4,6-tribromophenyl) acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-pyridin-2-ylacetamide, 1-[(4-chloro-3,5-dimethylphenoxy)acetyl]-4-methylpiperazine, and 1-benzyl-4-[(4-chloro-3,5-dimethylphenoxy)acetyl]piperazine—have

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25

Saini, Minaxi, Dinesh Kumar Mehta, and Rina Das. "Biological Evaluation and Molecular Docking Studies of Synthesized 5-Substituted-2-chlorophenyl-4-chloro Derivatives Bearing Pyridazinone Moiety." Letters in Organic Chemistry 17, no. 3 (2020): 170–83. http://dx.doi.org/10.2174/1570178616666190705152605.

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Chemical modification of pyridazinone may lead to a potent therapeutic agent. In this study, biological properties of pyridazinone derivatives were evaluated by assessing their antimicrobial and in-vitro antioxidant activities. The reaction of a mucochloric acid and 3-chloro-phenylhydrazine hydrochloride led to the formation of 5-aryl-4-chloro-2-(3-chloro-phenyl)-2H-pyridazin-3-one derivatives 2(a-j). The target compounds were synthesized using nucleophilic substitution reaction. In-silico molecular docking studies of the synthesized compounds were carried out with the help of V-Life Science M

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26

Tadić, Živorad D., Bratislav Ž. Jovanovic, and Dušan G. Antonović. "The thermal dealkylation of 2-chloro-4,6-bis(bornyl- and norbornylamino)-s-triazines." Collection of Czechoslovak Chemical Communications 55, no. 1 (1990): 256–60. http://dx.doi.org/10.1135/cccc19900256.

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The thermal dealkylation of 2-chloro-4,6-bis(isobornylamino)-s-triazine (I), 2-chloro-4,6-bis(bornylamino)-s-triazine (II), 2-chloro-4,6-bis(exo-norbornylamino)-s-triazine (III) and 2-chloro-4,6-bis(endo-norbornylamino)-s-triazine (IV) was performed at 250 °C. The high degree of dealkylation in the case of isobornyl derivative I was ascribed to a reaction via a seven-membered cyclic transition state, as well as to steric interaction of the dimethylmethylene group and the triazine ring. The presence of tricyclenes in the dealkylation products of this derivative also indicates that the reaction

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27

Journal, Baghdad Science. "Synthesis of Some Heterocyclic Compounds Derived from 2-Mercapto Benzoxazole." Baghdad Science Journal 10, no. 3 (2013): 766–78. http://dx.doi.org/10.21123/bsj.10.3.766-778.

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New series of 2-mecapto benzoxazole derivatives (1-20) incorporated into fused to different nitrogen and suphur containing heterocyclic were prepared from 2-meracpto benzoxazole, when treated with hydrazine hydrate to afford 2-hydrazino benzoxazol (1). Compound (1) converted to a variety of pyridazinone andphthalazinone derivatives (2-4) by reaction with different carboxylic anhydride. Also, reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-phenyl-1,3-thiazolidin-2,4-dione-2-(benzoxazole-2-yl-hydrazone) (6). Azomethines (7-10) were prepared through reaction of (1)

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Askar, Firyal W., Huda A. Hassan, and Nahida A. Jinzeel. "Synthesis of Some Heterocyclic Compounds Derived from 2-Mercapto Benzoxazole." Baghdad Science Journal 10, no. 3 (2013): 766–78. http://dx.doi.org/10.21123/bsj.2013.10.3.766-778.

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New series of 2-mecapto benzoxazole derivatives (1-20) incorporated into fused to different nitrogen and suphur containing heterocyclic were prepared from 2-meracpto benzoxazole, when treated with hydrazine hydrate to afford 2-hydrazino benzoxazol (1). Compound (1) converted to a variety of pyridazinone andphthalazinone derivatives (2-4) by reaction with different carboxylic anhydride. Also, reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-phenyl-1,3-thiazolidin-2,4-dione-2-(benzoxazole-2-yl-hydrazone) (6). Azomethines (7-10) were prepared through reaction of (1)

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Patel, H. S., and H. D. Desai. "Synthesis of Some New Azetidinone Derivatives Containing Aryl Sulfonyloxy Group." E-Journal of Chemistry 1, no. 4 (2004): 194–98. http://dx.doi.org/10.1155/2004/258752.

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Some novel azetidinone derivatives containing aryl sulfonyloxy group have been prepared. The 4-sulfonyloxy aniline derivative (2) has been prepared by reaction of 4-nitro phenol (sodium salt) with N-acetyl sulfanilyl chloride (ASC) followed by hydrolysis by ethanolic HCl. This compound (2) undergoes facile condensation reaction with aromatic aldehydes to yield different Schiff’s bases (3a-h). Cyclocondensation of compounds (3a-h) with chloro acetyl chloride yields different 2-azetidinone derivatives (4a-h).

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30

Yadav, Yadav, Manisha Negi, Ranjit Singh, and ,. Sanjay Singh. "Design, Synthesis and Characterization Of Benzofuran Derivatives For Anti-Bacterial Activity – A Research Article." Cuestiones de Fisioterapia 54, no. 1 (2025): 645–56. https://doi.org/10.48047/2jxp1j63.

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Many compounds are produced by different modifications of the benzofuran moiety, and each of those molecules exhibits a wide range of biological activity. New benzofuran derivatives (M5a-M5t) were produced using various reagents and techniques. The benzofuran derivatives (M5a-M5t) were made by combining 7-chlorobenzofuran-3-yl hydrazine and 5-nitrobenzofuran-3-yl)hydrazine with various benzaldehydes, such as 2-chloro, 4-Chloro, 4-Nitro, 2-Nitro, 4-Fluoro, 3-Methoxy, 4-bromo, 3-Bromo, 3-Chloro and 3-Nitrobenzaldehyde were used.

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Vashi, Kamal, and H. B. Naik. "Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity." E-Journal of Chemistry 1, no. 5 (2004): 272–75. http://dx.doi.org/10.1155/2004/158924.

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A series of Compound 4-(2᾽-hydroxy-3᾽-chloro-5᾽-ethyl phen-1᾽-yl)-1-(4᾽-tolyl)-3-chloro-2-azetidinone 4a-j have been prepared by the reaction of 2 -hydroxy-3 -chloro-5 -ethyl-N-(p-tolyl)-chalconimines 3a-j with chloroacetyl chloride in the presence of triethylamine. The Schiff base derivatives 3a-j has been prepared by the condensation of different substituted chalone derivatives 1 with p-toluidine 2. The synthesized compounds were screened for their antibacterial activity againstStaphylococcus aureusandEscherichia coli.

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32

Aesha F SH Abdassalam, Aesha F. SH Abdassalam, Semih Kurban Semih Kurban, and Nahide Gulsah Deniz and Cigdem Sayil Nahide Gulsah Deniz and Cigdem Sayil. "Synthesis and Characterization of New Naphtho- and Tetracyclic Diazaquinone Derivatives." Journal of the chemical society of pakistan 41, no. 5 (2019): 834. http://dx.doi.org/10.52568/000805/jcsp/41.05.2019.

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In this study, new 1,4-naphtho- and 5-nitro-1,4-naphtho derivatives containing N- and N,N-substituted groups which has not been reported yet, have been synthesized from 2,3-dichloronaphthalene-1,4-diones (1,9). Compounds of 2-choloro-3-((2,4,6-triflorophenyl)amino)naphthalene-1,4-dione (3) and 2-chloro-3-((4-florophenyl)amino)naphtalene-1,4-dione (7) were obtained by reactions of 2,3-dichloronaphthalene-1,4-dione 1 with 4-fluoroaniline (6) and 2,4,6-trifloroaniline (2), respectively involving a Michael addition. We reported the cyclization reactions of compounds 1 to benzo[g]pirido[3,2-b]quino

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33

Wang, Zisu, Denis Spasyuk, and Thomas Baumgartner. "On the reactivity of P-chloro dithieno[3,2-b:2′,3′-d]phosphole oxide." Canadian Journal of Chemistry 96, no. 6 (2018): 555–60. http://dx.doi.org/10.1139/cjc-2017-0619.

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The P-functionalization of dithieno[3,2-b:2′,3′-d]phosphole oxides via reaction of a P-chloro derivative with aromatic amines and alcohols is reported. The reactions proceed rapidly and provide the products in good yields, highlighting the synthetic versatility of the P-chloro dithienophosphole oxide toward effectively modifying the molecular scaffold without the need for elaborate phosphorus precursor syntheses. The resulting phosphinic amide and ester products show interesting photophysics that strongly depend on the nature of the P-substituent such as high luminescence quantum yields for th

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34

Jovanovic-Santa, Suzana, Vjera Pejanovic, and Julijana Petrovic. "A novel route to 3-hydroxy-16,17-seco-estrone derivatives." Journal of the Serbian Chemical Society 64, no. 5-6 (1999): 391–94. http://dx.doi.org/10.2298/jsc9906391j.

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Starting from 3-benzyloxy-17-hydroxy-16,17-secoestra-1,3,5(10)-triene-16-nitrile (1b), 17-tosylate 2b and also 17-chloro-, 17-bromo- and 17-iodo-derivatives 4b, 5b, and 6b, were obtained. The fluoro-derivative 3b was obtained from2b in the reaction with tetrabutyl ammonium fluoride. The deprotection of the 3-hydroxyl group was achieved by action of hydrogen in presence of Pd/C as a catalyst, yielding six new 3-hydroxy-16,17-seco-estrone derivatives.

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35

Gaikwad, D., R. Murkute, and S. Gaikwad. "Pharmacological Investigation of Fluoro, Iodo and Hydroxy Derivative of Chloro Substituted Homoisoflavonoids." Asian Journal of Organic & Medicinal Chemistry 7, no. 1 (2022): 31–36. http://dx.doi.org/10.14233/ajomc.2022.ajomc-p357.

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In present study, the synthesized substituted homoisoflavonoid derivatives were screened for their in vivo/in vitro antiarthritic activity, in vitro anti-inflammatory and DPPH free radical scavenging activity. The male Wistar rats were used for investigation of in vivo antiarthritic activity against complete freund’s adjuvant (CFA) induced arthritis and assessment was done for change in paw volume, serum marker enzymes (ALP, SGOT and SGPT) and membrane stabilization potential. in vitro anti-inflammatory activity was assessed by the protein denaturation method. In vitro free radical scavenging

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36

Chaudhari, J. A., R. P. Patel, and M. V. Hathi. "Studies on Novel Bisaryl Hydrazino-s-triazine Derivatives - Part 2." E-Journal of Chemistry 4, no. 3 (2007): 385–89. http://dx.doi.org/10.1155/2007/805637.

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Various 2(4-chloro phenyloxy)-4,6-bisarylhydrazino-1,3,5-triazines(3a-f) were prepared by reaction of 2(4-chloro phenyloxy)-4,6-dichloro -1,3,5-triazine and various aryl hydrazine derivatives. All the 3a-f derivatives were characterized by elemental analysis and IR spectral studies. All the compounds were screened for microbial activity against gram-positive and gram-negative bacteria.

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37

Bzowska, Agnieszka, Lucyna Magnowska, and Zygmunt Kazimierczuk. "Synthesis of 6-Aryloxy- and 6-Arylalkoxy-2-chloropurines and Their Interactions with Purine Nucleoside Phosphorylase from Escherichia coli." Zeitschrift für Naturforschung C 54, no. 12 (1999): 1055–67. http://dx.doi.org/10.1515/znc-1999-1210.

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The phase transfer method was applied to perform the nucleophilic substitution of 2,6- dichloropurines by modified arylalkyl alcohol or phenols. Since under these conditions only the 6-halogen is exchanged, this method gives 2-chloro-6-aryloxy- and 2-chloro-6-arylalkoxypurines. 2-Chloro-6-benzylthiopurine was synthesized by alkylation of 2-chloro-6-thiopurine with benzyl bromide. The stereoisomers of 2-chloro-6-(1-phenyl-1-ethoxy)purine were obtained from R- and S-enantiomers of sec.-phenylethylalcohol and 2,6-dichloropurine. All derivatives were tested for inhibition with purified hexameric E

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38

Werfeli, Ali, Svatava Voltrová, Viktor Prutianov, and Josef Kuthan. "Optically Active Furanoids Containing Cytosine-, Adenine- and Nicotinamide-Like Moieties." Collection of Czechoslovak Chemical Communications 61, no. 8 (1996): 1223–32. http://dx.doi.org/10.1135/cccc19961223.

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3-Hydroxymethyl-5-(2,3-O-isopropylidene-β-D-erythro-furanosyl)-2-methylfuran (2) prepared from 3-ethoxycarbonyl derivative 1 was converted to 3-chloromethyl-5-(2,3-O-isopropylidene-β-D-erythro-furanosyl)-2-methylfuran (3). Compound 3 reacted with cytosine, adenine, 6-chloropurine, 6-mercaptopurine, and nicotinamide to corresponding optically active heterocyclic derivatives 5-10 and 14. The 6-chloro derivative 9 was converted to 6-alkoxy derivatives 11 and 12 by the reaction with methanol or ethanol, respectively, in the presence of diazabicyclooctane. Dithionite reduction of quaternary chlorid

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39

Lamkane, Rachana B., Priyanka M. Khadasare, Pooja M. Shinde, et al. "Synthesis and Biological Screening of Novel Derivatives of Benzothiazol as Anticonvulsant Agents." SAR Journal of Medical Biochemistry 4, no. 01 (2023): 6–15. http://dx.doi.org/10.36346/sarjmb.2023.v04i01.002.

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The Benzothiazole ring system belongs to a much studied class of compound. In the last few decades, the chemistry of benzothiazole and their fused heterocyclic derivatives have received considerable attention owing to their significant and effective biological activity. The present study aimed to design and synthesize novel derivatives of bezothiazole obtained from 3-chloro-4-flouro aniline treated with potassium thiocynide with chloro acetyl chloride gives (7-chloro-6-fluro-1,3-benzothiazol-2-yl) acetyl chloride which is converted into hydrazide and yields the resultant compound derivatives o

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40

Konečný, Václav, Jozefína Žúžiová, Štefan Kováč, and Tibor Liptaj. "Synthesis of Novel 4-Amino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones." Collection of Czechoslovak Chemical Communications 62, no. 5 (1997): 800–808. http://dx.doi.org/10.1135/cccc19970800.

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Substituted 4-amino-2-phenyl-2H-pyridazin-3-ones 5a-5j have been prepared from 4-amino-5-chloro-2-phenyl-2H-pyridazin-3-one 1 which on reactions with acetyl chloride or acetic anhydride gives 4-acetylamino derivative 2 or 4-diacetylamino derivative 3, respectively. Derivatives 2 and 3 with dialkylamines and cyclic amines yielded appropriate 4-acetylamino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones 4a-4j. Subsequent alkaline hydrolysis of the acetylamino derivatives 4a-4j let to the title compounds 5a-5j, which were screened for pesticidal activity, but none of them reached activity of

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41

Dinçer, Hatice Akin, Ahmet Gül, and Makbule Burkut Koçak. "A novel route to 4-chloro-5-alkyl-phthalonitrile and phthalocyanines derived from it." Journal of Porphyrins and Phthalocyanines 08, no. 10 (2004): 1204–8. http://dx.doi.org/10.1142/s1088424604000544.

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A new route to the synthesis of 4-chloro-5-alkyl-phthalonitrile derivatives was shown by the displacement reaction of 4,5-dichloro-phthalonitrile and diethylmalonate, a CH -acidic precursor, in the presence of K 2 CO 3. Cyclotetramerization of 1-chloro-3,4-dicyano-6-(1,1-dicarbethoxy-methyl)benzene and the metal salt without any solvent gave the corresponding metallophthalocyanines ( M = Co , Cu or Pd ). Transesterification occurred when the reaction was carried out in hexanol in the presence of DBU to obtain the metal-free derivative. Treatment of 1-chloro-3,4-dicyano-6-(1,1-dicarbethoxy-meth

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42

Dabaeva, V. V., M. R. Baghdasaryan, I. M. Barkhudaryants, E. G. Paronikyan, and Sh Sh Dashyan. "Synthesis of new fused 3(4)-substituted 11-furylthieno[3,2-<i>d</i>]pyrimidine derivatives." Журнал общей химии 93, no. 9 (2023): 1351–57. http://dx.doi.org/10.31857/s0044460x23090056.

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A method was developed for the synthesis of new fused 3-alkyl-substituted derivatives of thieno[3,2- d ]pyrimidin-4(3 H )-ones based on 11-(2-furyl)-8,8-dimethyl-7,10-dihydro-8 H -pyrano[3′′,4′′:5′,6′]pyrido[3′,2′:4,5]-thieno[3,2- d ]pyrimidin-4(3 H )-one via nucleophilic substitution in the pyrimidine ring. A series of fused 4-amino-substituted 11-furylthieno[3,2- d ]pyrimidine derivatives was also synthesized from the corresponding 4-chloro derivative.

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43

Radhi Shahood, Anwar, and Zainab Muhsin Bdaiwi. "Synthesis and Evaluation of the Biological Activity of Heterocyclic Derivatives Containing the 1,3,4 Thiadiazole Ring." University of Thi-Qar Journal Of Medicine 28, no. 2 (2024): 259–76. https://doi.org/10.32792/jmed.v28i2.586.

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In this article: A series of new heterocyclic molecules with five and six members were prepared from 1,3,4-thiadiazole derivative with a terminal primary amine group and was used to synthesize a Schiff base (6) by interaction with 5-chloro salicylaldehyde and using ethanol as a solvent. After that, it was able to prepare numerous chemical compounds utilizing the Schiff base. Which contains a C=N group with (2-aminobenzoic acid, 2-mercaptobenzoic acid, valine, alanine, and sodium azide) to prepare hydroqinazoline (6a), thiazinone derivative (6b), and imidazolidine derivatives, (6c,6d). TLC foll

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44

Lauro, Figueroa-Valverde, Díaz-Cedillo Francisco, Rosas-Nexticapa Marcela, et al. "Design and Synthesis of Two Oxazine Derivatives Using Several Strategies." Journal of Chemistry 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/757953.

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Several oxazine derivatives have been synthesized; nevertheless, expensive reagents and special conditions are required. Therefore, in this study, two oxazine derivatives (2-chloro-3-{{2-[-(3-chloro-2-oxo-cyclobutyl)-(2,3-dimethoxy-9,10-dihydrostrychnid-10-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1H-naphtho[1,2-e][1,3-oxazin-2-yl)-2-phenyl-2,3-dihydro-1H-pyrazol-3-yl]-amino}-cyclobutanone and 2-chloro-3-{{2-[(3-chloro-2-oxo-cyclobutyl)-(1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1H-naphtho[1,2-e][1,3]oxazin-2-yl)-2-phenyl-2,3-dihydro-1H-pyrazol-3-yl]-amino}-cyclobutanone

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45

C., B. Rajashekar Reddy, Rajasekhara Reddy Sabbasani, Shivaji Naidu, Muralidhar B., and Jayachandra R. "An improved, practical and efficient method for the synthesis of novel N-chloro derivatives using calcium hypochlorite." Journal of Indian Chemical Society Vol. 92, Jun 2015 (2015): 847–50. https://doi.org/10.5281/zenodo.5636284.

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Organic Chemistry Division, Department of Chemistry, VIT University, Vellore-632 014, Tamilnadu, India <em>E-mail</em> : sekharareddy@vit.ac.in, sekharareddyiitm@gmail.com The developed method was employed in the synthesis of medicinally important compounds and intermediates in the organic synthesis. Herein we report a variety of novel <em>N</em>-chloro derivatives of benzisoxazole, benzimidazoles and several other <em>N</em>-chloro derivatives using 1.2 equivalents of calcium hypochlorite. The process does not require any additives like acids or bases and produced moderate to excellent yields

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46

Hoogeveen, A. P. J. "Derivatives of n-hexylamine with chloro-dinitro- and chloro-trinitronaphthalenes." Recueil des Travaux Chimiques des Pays-Bas 46, no. 12 (2010): 918–21. http://dx.doi.org/10.1002/recl.19270461210.

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47

Raad, Saad Jihad, Abed Abdul-Reda Nabeel та Mousa Juda Al-Shamari Amer. "Synthesis, characterization and molecular docking of new deriva-tives that contain quіnoxazlіne moities and study antioxidant prop-erties". Pakistan Journal of Analytical & Environmental Chemistry 23, Special Issue (2023): 174–88. https://doi.org/10.5281/zenodo.7702678.

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<strong>   Abstract </strong>     In this study we are prepared some novel derivatives from cetirizine Impurity A by react 1-((4-chlorophenyl)(phenyl) methyl)piperazine with 2-chloro acetyl chloride to prepared 2-chloro-1-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethan-1-one (1) from this directive prepared the derivatives (2-6) when react with o-phenylenediamine derivatives to obtain analytically pure quinoxaline derivatives .The reaction was monitored by thin‐layer chromatography (TLC) technique. All new compounds were characterized by melting points, element

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48

Tumosienė, Ingrida, Kristina Kantminienė, Ilona Jonuškienė, Artūras Peleckis, Sergey Belyakov, and Vytautas Mickevičius. "Synthesis of 1-(5-Chloro-2-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylic Acid Derivatives and Their Antioxidant Activity." Molecules 24, no. 5 (2019): 971. http://dx.doi.org/10.3390/molecules24050971.

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A series of novel 1-(5-chloro-2-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylic acid derivatives containing chloro, hydroxyl, isopropyl, nitro, nitroso, and amino substituents at benzene ring and 1-(5-chloro-2-hydroxyphenyl)-5-oxopyrrolidine-3-carbohydrazide derivatives bearing heterocyclic moieties were synthesized. Antioxidant activity of the synthesized compounds was screened by DPPH radical scavenging method and reducing power assay. A number of compounds were identified as potent antioxidants. Antioxidant activity of 1-(5-chloro-2-hydroxyphenyl)-4-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)p

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49

Deshpande, Shreenivas R., and K. Vasantakumar Pai. "Synthesis, Antibacterial and Analgesic Activities of 4-[1-Oxo-3-(substituted aryl)-2-propenyl]-3-(4-methylphenyl) sydnones." E-Journal of Chemistry 7, no. 1 (2010): 59–64. http://dx.doi.org/10.1155/2010/237473.

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A series of sydnone derivatives containing styryl ketone moiety, 4-[1-oxo-3-(substituted aryl)-2-propenyl]-3-(4-methylphenyl)sydnones (6a-i) has been synthesized and characterized by spectral data. The synthesized compounds have been screened for preliminary antibacterial activity by cup plate method and analgesic activity by the method of acetic acid induced writhing in mice. The chloro and nitro derivatives showed good antibacterial activity against both gram positive and gram negative bacteria while the chloro and furyl derivatives exhibited highest analgesic effect among the series.

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50

Swamy, Peraka, Macharla Arun Kumar, Marri Mahender Reddy, Mameda Naresh, Kodumuri Srujana та Nama Narender. "The vicinal functionalization of olefins: a facile route to the direct synthesis of β-chlorohydrins and β-chloroethers". RSC Adv. 4, № 50 (2014): 26288–94. http://dx.doi.org/10.1039/c4ra01641f.

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A general and green approach for the highly regio- and stereoselective synthesis of α-hydroxy-β-chloro and α-methoxy-β-chloro derivatives from olefins using inexpensive and industrially acceptable reagents is reported.

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