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Journal articles on the topic 'Chloroacetoxy derivatives'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Musayeva, B. I., V. M. Farzaliyev, G. G. Ismayilova, N. N. Novotorzhina, and M. R. Safarova. "Mixed esters of xanthogenic acids containing carbonyl, dithiocarbamine and thiocyane group and their research as additives improving tribological characteristics." World of Oil products the Oil Companies Bulletin 04, no. 1 (2021): 60–64. http://dx.doi.org/10.32758/2071-5951-2021-1-4-60-64.

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On the basis of environmentally friendly raw materials of glycerol, by its interaction with monochloroacetic acid, 1,2,3-(trichloroacetyl)triglyceride was synthesized, which is used for further syntheses of xanthogenic acid derivatives containing a number of functional groups  dithiocarbamic, thiocyanic. The reaction of 1,2,3-(trichloroacetyl) triglyceride with potassium alkylxanthate in a ratio of 1:1 and 1:2 gave 1-butylxanthogenatoacetoxy-2,3-(dichloroacetoxy) propane and 1,3-di(alkylxanthogenatoacetoxy)-2-chloroacetoxypropane. Mixed esters of xanthogenic acid containing dithiocarbamic and

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2

Yassin, Fathy A. "Synthesis of New Thieno- and Pyrazolo- pyridazine Derivatives." Journal of Chemical Research 2005, no. 4 (2005): 270–73. http://dx.doi.org/10.3184/0308234054213474.

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5,6-Di(pyridin-2-yl)-3-thioxo-2,3-dihydropyridazine-4-carbonitrile 2 has been reacted with ahalocompounds, such as chloroacetone, chloroacetamide, ethyl chloroacetate and chloroacetic acid gave the corresponding 2-S-alkylated pyridazine derivatives 3, 6, 10 and 13 which have been cyclised to give the corresponding thienopyridazine derivatives 4, 7, 11, and 14 respectively. Reaction of 15 with hydrazine hydrate gave the corresponding pyrazolopyridazine 16.

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3

Tolba, Mahmoud S., Mostafa Sayed, Shaban A. A. Abdel-Raheem, Taher A. Gaber, Adel M. Kamal El-Dean, and Mostafa Ahmed. "Synthesis and spectral characterization of some new thiazolopyrimidine derivatives." Current Chemistry Letters 10, no. 4 (2021): 471–78. http://dx.doi.org/10.5267/j.ccl.2021.4.004.

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Thiazolopyrimidnes are considered one of the most interesting classes in heterocyclic chemistry due to their pharmaceutical importance. Herein, we report the synthesis of some new heterocyclic compounds containing thiazolopyrimidine starting from compound (1) which was previously prepared in literature. The starting compound was allowed to react with different alkylating agents such as chloroacetone, chloroacetyl chloride, and phenacyl bromide to afford derivatives (2-4). Compound (5), benzylidene derivative, was obtained by the reaction of compound (2) with benzaldehyde while amino-dicarbonit

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4

Athraa H Mekky and Sajida M Thamir. "Synthesis, characterisation and antibacterial evaluation of some novel 1-phenyl-1h-tetrazole-5-thiol derivatives." International Journal of Research in Pharmaceutical Sciences 10, no. 2 (2019): 1136–42. http://dx.doi.org/10.26452/ijrps.v10i2.394.

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The aim of the study is to synthesise and. Characterize — some novel, "tetrazole., -5-thiol” derivatives. Firstly, the “1-phenyl-1H7-tetrazole-5-thiol” (A1) has been., synthesised by the reaction of phenylisothiocyanate with NaN3 in water as a solvent. Secondly, the tetrazole-5-thiol derivatives (A2-A4) were synthesised by the alkylation reaction of the compound (A1) with chloroacetone, phenacyl bromide and chloromethyl acetate respectively. The resulted percentage yield was relatively high (92%, %95, %90 respectively). Compound (A5) was synthesised by the reaction of ethyl acetate tetrazole d

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5

Darwish, Elham S. "Facile Synthesis and Antimicrobial Evaluation of Some New Heterocyclic Compounds Incorporating a Biologically Active Sulfamoyl Moiety." Scientific World Journal 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/165495.

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A facile and convenient synthesis of new heterocyclic compounds containing a sulfamoyl moiety suitable for use as antimicrobial agents was reported. The precursor 3-oxo-3-phenyl-N-(4-sulfamoylphenyl)propionamide was coupled smoothly with arenediazonium salt producing hydrazones which reacted with malononitrile or triethylorthoformate affording pyridazine and triazine derivatives, respectively. Also, the reactivity of the same precursor with DMF-DMA was followed by aminotriazole; aromatic aldehydes was followed by hydrazine hydrate, triethylorthoformate, or thiourea affording triazolo[1,5-a]pyr

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6

Salem, Mohamed A., Samir Y. Abbas, Marwa A. M. Sh El-Sharief, et al. "Novel Structural Hybrids of Pyrrole and Thiazole Moieties: Synthesis and Evaluation of Antibacterial and Antifungal Activities." Acta Chimica Slovenica 68, no. 4 (2021): 990–96. http://dx.doi.org/10.17344/acsi.2021.6980.

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One of the best ways to design new biocidal agents is synthesizing hybrid molecules by combining two or more bioactive moieties in a single molecular scaffold. So, new series of pyrroles bearing a thiazole moiety were synthesized using 1-methyl-1H-pyrrole-2-carbaldehyde thiosemicarbazones 1a–c. Cyclization of thiosemicarbazone derivatives 1a–c with ethyl chloroacetate, ethyl 2-chloropropanoate, chloroacetone and phenacyl bromide afforded the corresponding thiazolidin-4-ones 2a–c, 5-methylthiazolidin-4-ones 3a–c, 4-methyl-2,3-dihydrothiazoles 4a–c, and 4-phenyl-2,3-dihydrothiazoles 5a–c, respec

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7

Hradil, Pavel, Jan Vaněček, Jan Hlaváč, and Juraj Ševčík. "Synthesis of 2-Substituted-6,7-dimethoxy- and 6,7,8-Trimethoxy-3-hydroxyquinolin-4(1H)-ones." Collection of Czechoslovak Chemical Communications 64, no. 2 (1999): 257–64. http://dx.doi.org/10.1135/cccc19990257.

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Acetonyl and phenacyl esters of 4,5-dimethoxy- and 3,4,5-trimethoxyanthranilic acids 3 were prepared by reduction of corresponding nitro derivatives 2. Acetonyl 4,5-dimethoxyanthranilate (3a) was prepared by reaction of 4,5-dimethoxyanthranilic acid and chloroacetone. Cyclization of these acetonyl and phenacyl esters in polyphosphoric acid provided the corresponding 2-substituted-6,7-dimethoxy- and 6,7,8-trimethoxy-3-hydroxyquinolin-4(1H)-ones 4. A new method of the thermal cyclization is also described. The structure of the prepared compounds was confirmed by 1H NMR spectroscopy.

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8

El-Hagrassey, Eman A., Ehab Abdel-Latif, and Gamal M. Abdel-Fattah. "Synthesis and efficiency of new pyridine, chromene and thiazole containing compounds as antimicrobial and antioxidant agents." Bulletin of the Chemical Society of Ethiopia 36, no. 1 (2022): 137–48. http://dx.doi.org/10.4314/bcse.v36i1.12.

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ABSTRACT. The versatile scaffold, N'-(2-cyanoacetyl)-2-hydroxybenzohydrazide (3) was utilized in the production of new pyridine, chromene and thiazole derivatives as antimicrobial and antioxidant agents. The synthetic strategy involves the treatment of precursor 3 with various arylidene-malononitrile and 3-aryl-2-cyanoacrylate compounds to furnish substituted pyridines 5 and 7. The interaction of 3 with salicylaldehyde and/or phenyl isothiocyanate followed by cyclization with chloroacetone produced the corresponding 2-imino-2H-chromene-3-carbohydrazide and (thiazol-2-ylidene-acetyl)-salicylic

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9

Murat Saracoglu, Murat Saracoglu, Zulbiye Kokbudak Zulbiye Kokbudak, and Zeynep imen and Fatma Kandemirli Zeynep imen and Fatma Kandemirli. "Synthesis and DFT Quantum Chemical Calculations of Novel Pyrazolo[1,5-c]pyrimidin-7(1H)-one Derivatives." Journal of the chemical society of pakistan 41, no. 3 (2019): 479. http://dx.doi.org/10.52568/000746/jcsp/41.03.2019.

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In this study, a convenient procedure for the preparation of pyrazolo[1,5-c]pyrimidin-7(1H)-one derivatives is described. The new pyrazolo[1,5-c]pyrimidin-7(1H)-one derivatives (2a, b) were synthesized from the cyclocondensation reaction of the compounds 1-amino-5-(4-methoxybenzoyl)-4-(4-methoxyphenyl)pyrimidin-2(1H)-one (1a) and 1-amino-5-(4-methylbenzoyl)-4-(4-methylphenyl)pyrimidin-2(1H)-one (1b) with α-chloroacetone. The structures of the compounds (2a, b) were characterized by elemental analysis, FT-IR, 1H-NMR and 13C-NMR spectroscopic techniques. In addition to experimental study in orde

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10

M., B. Deshmukh, S. Jagtap S., A. Deshmukh S., D. Jadhav S., V. Anbhule P., and W. Suryawanshi A. "Synthesis and biological activity of some benzothiazolyl thiazolidinones." Journal of Indian Chemical Society Vol. 84, May 2007 (2007): 498–500. https://doi.org/10.5281/zenodo.5820289.

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Department of Chemistry, Shivaji University, Kolhapur-416 004, Maharashtra, India <em>E-mail</em> : m_deshmukhl@rediffmail.com <em>Manuscript received 1 June 2006, accepted 22 March 2007</em> A facile route for the synthesis of some thiazolidinone derivatives incorporating a benzothiazole moiety has been reported. <em>S</em>-(2-Propanoyl)-1,3-benzothiazole (2) was synthesized by reacting 2-mercapto benzothiazole with chloroacetone in dry acetone, which was subsequently reacted with substituted aryl hydrazides to give the corresponding hydrazones (3}. These on cyclocondensation with mercaptoace

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11

R. Harish Kumar, D., and M. D. Karvekar. "Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial Activity." E-Journal of Chemistry 7, no. 2 (2010): 636–40. http://dx.doi.org/10.1155/2010/817480.

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2-Acetyl benzofuran (1) was synthesized by refluxing salicylaldehyde and dry chloroacetone in presence of potassium carbonate. The product formed was reacted with 2-aminobenzothiazole with catalystp-toluene sulphonic acid to formN-[(1Z)-1-(benzofuran-2-yl)ethylidene]1,3-benzothiazol-2-amine (2). In cold condition, Staudinger reaction was carried out for compound (2) with various acid chlorides in presence of triethylamine to synthesize 4-[1-benzofuran-2-yl]-1-[1, 3-benzothiazol-2-yl]-4-methylazetidin-2-one (3a-3j). All the synthesized compounds were characterized on the basis of analytical dat

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12

Veerapur, Bharathi Sharanappa, L. N. Netravati, H. M. Naveenakumari, and K. M. Basavaraja. "Design, synthesis, molecular docking and biological evaluation of some pyridinone bearing scaffold benzofuran as antimicrobial and antioxidant activity." Current Chemistry Letters 12, no. 1 (2023): 167–74. http://dx.doi.org/10.5267/j.ccl.2022.8.008.

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A series of benzofuran derivatives compounds have been designed and synthesized. Here, Benzofuran linked with pyridinone compounds is reported. The desired compounds were prepared by using 2-nitrosalisaldehydnitrile (1). After, this is treated with chloroacetone, which results in the formation of 1-(3-amino-5-nitro-1-benzofuran-2-yl) ethanone (2). Later the 3a-b is produced by a reaction of acetylation and benzylation on compound 2 respectively. The alkylation of compounds 4a-b react with sodium hydroxide, we get new pyridinone compounds. All the synthesized compounds were characterized by IR,

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13

Konovalenko, Artem, Oleh Shablykin, Olga Shablykina, Andrii Kozytskyi, and Volodymyr Brovarets. "Convenient and versatile method of 8-amino-6-(2-R-thiazol-4-yl)-1,7-naphthyridines synthesis." Current Chemistry Letters 13, no. 1 (2024): 163–72. http://dx.doi.org/10.5267/j.ccl.2023.7.004.

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On the base of 3-formylpicolinic acid by two successive heterocyclizations (the formation of a pyrone fragment by the cyclization of chloroacetone with the carboxyl and formyl groups; and the construction of the thiazole cycle through the bromination of the acetyl fragment and following interaction with thioamides), 6-(2-(phenyl/thiophen-2-yl)thiazole-4-yl)-8H-pyrano[3,4-b]pyridin-8-ones were obtained; and then the pyrone fragment was converted to pyridone by the action of ammonia under high pressure. When such 6-(2-R-thiazol-4-yl)-1,7-naphthyridin-8(7H)-ones reacted with triflic anhydride, O-

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14

Agili, Fatimah. "Novel Thiazole Derivatives Containing Imidazole and Furan Scaffold: Design, Synthesis, Molecular Docking, Antibacterial, and Antioxidant Evaluation." Molecules 29, no. 7 (2024): 1491. http://dx.doi.org/10.3390/molecules29071491.

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Carbothioamides 3a,b were generated in high yield by reacting furan imidazolyl ketone 1 with N-arylthiosemicarbazide in EtOH with a catalytic amount of conc. HCl. The reaction of carbothioamides 3a,b with hydrazonyl chlorides 4a–c in EtOH with triethylamine at reflux produced 1,3-thiazole derivatives 6a–f. In a different approach, the 1,3-thiazole derivatives 6b and 6e were produced by reacting 3a and 3b with chloroacetone to afford 8a and 8b, respectively, followed by diazotization with 4-methylbenzenediazonium chloride. The thiourea derivatives 3a and 3b then reacted with ethyl chloroacetate

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15

Al-Wahaibi, Lamya H., Essmat M. El-Sheref, Alaa A. Hassan, et al. "Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAFV600E Dual Inhibitors Endowed with Antiproliferative Activity." Pharmaceuticals 16, no. 7 (2023): 1014. http://dx.doi.org/10.3390/ph16071014.

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2,3,4-trisubstituted thiazoles 3a–i, having a methyl group in position four, were synthesized by the reaction of 1,4-disubstituted thiosemicarbazides with chloroacetone in ethyl acetate/Et3N at room temperature or in ethanol under reflux. The structures of new compounds were determined using NMR spectroscopy, mass spectrometry, and elemental analyses. Moreover, the structure of compound 3a was unambiguously confirmed with X-ray analysis. The cell viability assay of 3a–i at 50 µM was greater than 87%, and none of the tested substances were cytotoxic. Compounds 3a–i demonstrated good antiprolife

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16

Ramazani, Ali, Fatemeh Zeinali Nasrabadi, Zahra Karimi, and Morteza Rouhani. "Four-Component Synthesis of Disubstituted 1,3,4-Oxadiazoles fromN-Isocyaniminotriphenylphosphorane, Phenylacetylenecarboxylic Acid, Chloroacetone Derivatives, and Primary Amines." Synthetic Communications 43, no. 13 (2013): 1818–30. http://dx.doi.org/10.1080/00397911.2012.673447.

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17

Kumar, Mahesh, K. M. Basavaraja, Manjunatha Harihara Mathada, and M. Mylarappa. "Synthesis and Antimicrobial activity of 1-(3-amino-5-chloro-2, 3-dihydro-1-benzofuran-2-yl) ethan-1-one [2, 1-b]-furan and their derivatives." Research Journal of Chemistry and Environment 26, no. 11 (2022): 185–96. http://dx.doi.org/10.25303/2611rjce1850196.

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The current study is focused on the conversion of 2- chlorosalicylaldehyde into its oxime which was then converted into 5-chloro-2-hydroxy-benzonitrile 1, a key starting material for the present synthetic work. The nitrile 1 on reaction with chloroacetone/phenacyl bromide/4-chlorophenacyl bromide in anhydrous acetone and potassium carbonate gave 2-acyl-3- amino-5-chlorobenzofuran (2a-c). Acetylation of compounds 2a-c furnishes 2-acyl-3acetamido-5- chlorobenzofuran (3a-c). Compounds 3a-c on further treatment with hydrazine hydrate undergo ring closure producing 3-amino-8- chloro-2, 4-dimethyl-3

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18

Shekhovtsov, Nikita A., Elena B. Nikolaenkova, Alexey A. Ryadun, Denis G. Samsonenko, Alexsei Ya Tikhonov, and Mark B. Bushuev. "ESIPT-Capable 4-(2-Hydroxyphenyl)-2-(Pyridin-2-yl)-1H-Imidazoles with Single and Double Proton Transfer: Synthesis, Selective Reduction of the Imidazolic OH Group and Luminescence." Molecules 28, no. 4 (2023): 1793. http://dx.doi.org/10.3390/molecules28041793.

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1H-Imidazole derivatives establish one of the iconic classes of ESIPT-capable compounds (ESIPT = excited state intramolecular proton transfer). This work presents the synthesis of 1-hydroxy-4-(2-hydroxyphenyl)-5-methyl-2-(pyridin-2-yl)-1H-imidazole (LOH,OH) as the first example of ESIPT-capable imidazole derivatives wherein the imidazole moiety simultaneously acts as a proton acceptor and a proton donor. The reaction of LOH,OH with chloroacetone leads to the selective reduction of the imidazolic OH group (whereas the phenolic OH group remains unaffected) and to the isolation of 4-(2-hydroxyphe

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19

Ramazani, Ali, Fatemeh Zeinali Nasrabadi, Zahra Karimi, and Morteza Rouhani. "Preparation of Fully Substituted 1,3,4-Oxadiazole Derivatives from N-Isocyaniminotriphenylphosphorane, (E)-Cinnamic Acids, Chloroacetone and Primary Amines." Bulletin of the Korean Chemical Society 32, no. 8 (2011): 2700–2704. http://dx.doi.org/10.5012/bkcs.2011.32.8.2700.

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20

Ho, Yuh Wen, and Wei Hua Yao. "Thioxopyrimidine in Heterocyclic Synthesis III: Synthesis and Properties of Some Novel Heterocyclic Chalcone Derivatives Containing a Thieno[2,3-d]pyrimidine-Based Chromophore." Journal of Chemistry 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/649576.

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Cyclization of 4-methyl-2-phenyl-6-thioxo-1,6-dihydropyrimidine-5-carbonitrile1with chloroacetone in DMF in the presence of excess potassium carbonate anhydrous gave the 1-(5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidin-6-yl)ethanone3, which can react with 2,5-dimethoxytetrahydrofuran in glacial acetic acid producing the 1-[4-methyl-2-phenyl-5-(1H-pyrrol-1-yl)thieno[2,3-d]pyrimidin-6-yl]ethanone4. On the other hand, a series of novel 3-aryl-1-[4-methyl-2-phenyl-5-(1H-pyrrol-1-yl)-thieno[2,3-d]pyrimidin-6-yl]prop-2-en-1-one chalcone dyes6a—nwere obtained by the condensation reaction of 1-[4-me

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21

Mohareb, Rafat M., and Eman M. Samir. "The Reaction of Cyanoacetylhydrazine with Chloroacetone: Synthesis of 1,2,4-Triazine, 1,3,4-Oxadiazine and Their Fused Derivatives with Antitumor Activities." Open Journal of Medicinal Chemistry 02, no. 01 (2012): 1–9. http://dx.doi.org/10.4236/ojmc.2012.21001.

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22

Ramazani, Ali, Fatemeh Zeinali Nasrabadi, Zahra Karimi, and Morteza Rouhani. "ChemInform Abstract: Four-Component Synthesis of Disubstituted 1,3,4-Oxadiazoles from N-Isocyaniminotriphenylphosphorane, Phenylacetylenecarboxylic Acid, Chloroacetone Derivatives, and Primary Amines." ChemInform 44, no. 40 (2013): no. http://dx.doi.org/10.1002/chin.201340134.

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23

Ramazani, Ali, Fatemeh Zeinali Nasrabadi, and Yavar Ahmadi. "One-Pot, Four-Component Synthesis of Fully Substituted 1,3,4-Oxadiazole Derivatives from (Isocyanoimino)triphenylphosphorane, a Primary Amine, an Aromatic Carboxylic Acid, and Chloroacetone." Helvetica Chimica Acta 94, no. 6 (2011): 1024–29. http://dx.doi.org/10.1002/hlca.201000356.

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Ramazani, Ali, Fatemeh Zeinali Nasrabadi, and Yavar Ahmadi. "ChemInform Abstract: One-Pot, Four-Component Synthesis of Fully Substituted 1,3,4-Oxadiazole Derivatives from (Isocyanoimino)triphenylphosphorane, a Primary Amine, an Aromatic Carboxylic Acid, and Chloroacetone." ChemInform 42, no. 41 (2011): no. http://dx.doi.org/10.1002/chin.201141125.

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Burbulienė, Milda Malvina, Julita Dargytė, Eglė Maldutytė, and Povilas Vainilavičius. "Simple and efficient synthesis of new N(3)-, O- and S-substituted 2-methylthio-6-phenylpyrimidin-4(3H)-one based derivatives." Chemija 27, no. 2 (2016). https://doi.org/10.6001/chemija.2016.27.2.6.

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Reactions of sodium salt of 2-methylthio-6-phenylpyrimidin-4(3H)-one with chloroacetone, ω-bromoacetophenone and methyl bromoacetate in different solvents were studied. Regioselective N(3)-alkylation took place in tetrachloromethane at reflux, while in dimethylformamide at ambient temperature O-acylmethyl derivatives were obtained. 2-Methylthio-6-phenylpyrimidine-4(3H)-thione reacted with chloroacetone and ω-bromoacetophenone in a sodium methoxide–methanol solution to give the corresponding S-substituted derivatives. Oxidation reactions of the resulting N(3)-, O- and S-acylmethyl derivatives w

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Al‐Harbi, Reem A. K., Heba A. Emam, and Samir Y. Abbas. "Synthesis of new 2‐pyridinone and thiazole derivatives containing coumarin moiety." Journal of Heterocyclic Chemistry, October 22, 2023. http://dx.doi.org/10.1002/jhet.4746.

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AbstractCoumarin has shown considerable therapeutic potency because of its versatile biological prosperities. Also, pyridines have been adopted in medicinal chemistry as potent ring. Moreover, several investigations reported the potency of thiazole‐containing compounds. So, during this research, new functionalized 2‐pyridinone and thiazole derivatives bearing coumarin moiety were aimed to synthesize. Many trials to obtain the 6‐amino‐2‐oxo‐pyridine‐3,5‐dicarbonitriles through the condensation of cyanoacetohydrazone of 3‐acetyl coumarin with 2‐(arylidene)malononitriles were carried out using di

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Elmorsy, Mohamed R., Sara H. Yousef, Ehab Abdel-Latif, and Safa A. Badawy. "Molecular structures and in Silico molecular docking of new pyrazine-based heterocycles as antibacterial agents." BMC Chemistry 19, no. 1 (2025). https://doi.org/10.1186/s13065-025-01535-w.

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Abstract Compound 2-(2-cyanoacetamido)pyrazine (3) serves as a key precursor for synthesizing various new pyrazine-linked heterocycles, including pyridine, thiazole, pyrazole, chromene, and pyrazolotriazine derivatives. Pyrazine-pyridone analogues 5a-d were obtained by reacting compound 3 with substituted 2-(arylidene)malononitriles (4a–d). Substituted pyrazine-thiazoles (8 and 9) were synthesized by condensation with phenyl isothiocyanate, followed by cyclization using ethyl bromoacetate or chloroacetone. Pyrazine-chromenes (14, 15) and pyrazine-naphthoxazines (16, 17) were prepared by reacti

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Burbulienė, Milda M., Rita Mažeikaitė, Lina Rekovič, and Povilas Vainilavičius. "Quinazoline-4-thiones: formation and reaction with hydrazine hydrate." Chemija 26, no. 4 (2015). https://doi.org/10.6001/chemija.2015.26.4.6.

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2-(Methylthio)quinazoline-4(3H)-thione was synthesized by the reaction of the corresponding 4-oxo quinazoline with Lawesson’s reagent (LR). 2-(Methylthio-4-thioxoquinazolin-3-yl)acetate was obtained in a similar way, while (4-oxoquinazolin-3-yl)ketones reacted with LR to give a mixture of thionation products – (4-thioxoquinazolin-3-yl)ketones and [1,3]thiazolo[2,3-b]quinazoline-5-thiones. Alkylation of 2-(methylthio)quinazoline-4(3H)-thione with chloroacetone, ω-bromoacetophenone or ethyl bromoactate gave the corresponding 4-S-substituted derivatives, which in the reaction with hydrazine hydra

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Khidre, Rizk E., and Ibrahim Ali M. Radini. "Design, synthesis and docking studies of novel thiazole derivatives incorporating pyridine moiety and assessment as antimicrobial agents." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-86424-7.

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AbstractA novel series of substituted 4,6-dimethyl-2-oxo-1-(thiazol-2-ylamino)-1,2-dihydropyridine-3-carbonitrile derivatives6,9,13,15, and17was synthesized in a good to excellent yield from the reaction of 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)thiourea with 2-oxo-N'-arylpropanehydrazonoyl chloride, chloroacetone,α-bromoketones, ethyl chloroacetate, and 2,3-dichloroquinoxaline, respectively. The potential DNA gyrase inhibitory activity was examined using in silico molecular docking simulation. The novel thiazoles exhibit dock score values between − 6.4 and − 9.2 kcal/mol and they were

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Mohareb, Rafat M., Karam A. El-Sharkawy, Abeer A. Mohamed, and Fatma Omar Al Farouk. "New approaches for the synthesis N-alkylated benzo[b]thiophene derivatives together with their Antiproliferative and molecular docking studies." Anti-Cancer Agents in Medicinal Chemistry 23 (March 16, 2023). http://dx.doi.org/10.2174/1871520623666230316103419.

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Background: 2-Amino thiophene derivatives are important compounds not only for their uses in many heterocyclic reactions but also due to their wide range of pharmaceutical and biological activities. background: Sulfur containing heterocyclic compounds are important compounds that were recently used in many heterocyclic reactions. 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile belongs to these compounds which was used in plenty of reactions to produce biologically active compounds. Objective: The aim of this work was to explore a number of new heterocyclic derivatives, studying thei

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Keltoum, Cheham Oum, Zaid Mohamed El Amine, Nasser Belboukhari, Khaled Sekkoum, and Hassan Y. Aboul-Enein. "Synthesis And Chiral Separation Of Some New Derivatives Of imidazo [1, 2-a] pyridine." Current Analytical Chemistry 19 (June 26, 2023). http://dx.doi.org/10.2174/1573411019666230626162832.

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Abstract:

Introduction: Mannich base is the result of the three-part chemical reaction known as the Mannich reaction, which includes the amino alkylation of an acidic proton adjacent to a carbonyl group by formaldehyde and either a primary or secondary amine. Method and Material: In a 1L flask, dissolve 28.2g (0.3mol) of 2-aminopyridine, and 400mL of ethanol, then add 32.6g (0.3mol) of chloroacetone and put 30 drops of acetic acid. The organic phases are combined and dried with Magnesium sulfate. After solvent evaporation, we have recovered our product which is a 2-methylimidazo [1, 2-a] pyridine produc

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