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Journal articles on the topic 'Chloroacetyl derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Sokhraneva, V. A., D. A. Yusupova, V. S. Boriskin, and N. V. Groza. "Obtaining substituted phenol derivatives with potential antimicrobial activity." Fine Chemical Technologies 17, no. 3 (2022): 210–30. http://dx.doi.org/10.32362/2410-6593-2022-17-3-210-230.

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Objectives. With the growing resistance of pathogenic microorganisms to antibiotics, the development of new antimicrobial drugs offering specific mechanisms of action becomes an urgent task. Only few antimicrobials offer a broad spectrum of activity against gram-positive and gram-negative bacteria, molds, and yeasts. In this regard, the purpose of the work was to develop methods for synthesizing biologically active derivatives of alkyl-substituted phenols (reactions at the hydroxy group) to study their biological effect.Methods. The synthesis of imidazole acetates of substituted phenols was ca

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2

(Miss), A. M. DAVE, N. BHATT K., K. UNDAVIA N., and B. TRIVEDl P. "Studies on Synthesis of Haloginated Phenothiazine Derivatives." Journal of Chemical Indian Society Vol. 65, May 1988 (1988): 365–66. https://doi.org/10.5281/zenodo.6279483.

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University Department of Chemistry, Bhavnagar University Bhavnagar-.364-002 <em>Manuscript received 12 October 1987, revised 4 February 1988, accepted 21 March 1988</em> 1,3,7,9-Tetrachloro-10-(substituted-benzthiazol-2<em>'</em>-ylaminoacetyl)phenothiazines have been synthesised by condensation of the chloroacetyl derivative of phenothiazine with substituted-2-aminobenzthiazoles. The haloginated derivatives of phenothiazine were screened for their antibacterial efficacy.

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3

Tolba, Mahmoud S., Mostafa Sayed, Shaban A. A. Abdel-Raheem, Taher A. Gaber, Adel M. Kamal El-Dean, and Mostafa Ahmed. "Synthesis and spectral characterization of some new thiazolopyrimidine derivatives." Current Chemistry Letters 10, no. 4 (2021): 471–78. http://dx.doi.org/10.5267/j.ccl.2021.4.004.

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Thiazolopyrimidnes are considered one of the most interesting classes in heterocyclic chemistry due to their pharmaceutical importance. Herein, we report the synthesis of some new heterocyclic compounds containing thiazolopyrimidine starting from compound (1) which was previously prepared in literature. The starting compound was allowed to react with different alkylating agents such as chloroacetone, chloroacetyl chloride, and phenacyl bromide to afford derivatives (2-4). Compound (5), benzylidene derivative, was obtained by the reaction of compound (2) with benzaldehyde while amino-dicarbonit

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4

Flefel, Eman M., Walaa I. El-Sofany, Mahmoud El-Shahat, Arshi Naqvi, and Eman Assirey. "Synthesis, Molecular Docking and in Vitro Screening of Some Newly Synthesized Triazolopyridine, Pyridotriazine and Pyridine–Pyrazole Hybrid Derivatives." Molecules 23, no. 10 (2018): 2548. http://dx.doi.org/10.3390/molecules23102548.

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A series of novel pyridine and fused pyridine derivatives have been prepared starting from 6-(3,4-dimethylphenyl)-2-hydrazinyl-4-(thiophen-2-yl)-pyridine-3-carbonitrile 1 which on treatment with appropriate formic acid, acetic acid/ acetic anhydride, benzoyl chloride and/or carbon disulfide afforded the corresponding triazolopyridine derivatives 2–5. Also, treatment of hydrazide 1 with diethyloxalate, chloroacetyl chloride, chloroacetic acid and/or 1,2-dichloroethane yielded the corresponding pyridotriazine derivatives 7–10. Further transformation of compound 1 with a different active methylen

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5

KRISHNA, C. JOSHI, N. PATHAK VIJAI, and K. GOYAL MAHENDRA. "Synthesis, Anticonvulsant and Analgesic Activities of some New Fluorine containing 1,3,5-Trisubstituted-hydantoins." Journal of Indian Chemical Society Vol. 62, Nov 1985 (1985): 904–8. https://doi.org/10.5281/zenodo.6325270.

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Department of Chemistry, University of Rajasthan Jaipur-302 004 Fifteen new fluorine containing Mannich bases derived from 1,5-disubstituted-arylhydantoins have been synthesised by treating the appropriate 1,5-disubstituted-arylhydantoins with secondary amine and formaldehyde in ethanol. Seven 1,5-disubstituted-arylhydantoins were treated with chloroacetyl chloride and the resulting 3chloroacetyl-derivatives converted into the corresponding 3-dialkylaminoacetyl-1,5- disubstituted-arylhydantoins on treatment with secondary amines. Representative compounds have been screened

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6

Journal, Baghdad Science. "Synthesis of Some new 2-(4-Aryliminophenoxy)N-Arylacetamide Via p-hydroxy benzaldehyde." Baghdad Science Journal 11, no. 2 (2014): 486–90. http://dx.doi.org/10.21123/bsj.11.2.486-490.

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Chloroacetamide derivatives (2a-g) have been prepared through reaction of chloroacetyl chloride(1) (which prepared by the reaction of chloroacetic acid with thionyl chloride) with primary aromatic amines and sulfa compounds to afford compounds (2a-g) which then reacted with p-hydroxy benzaldehyde via Williamson reaction to obtaine the new compounds 2-(4-formyl phenoxy)-N-aryl acetamide (3a-g). Finally , compounds (3a-g) will be use as a good synthon to prepare the Schiff bases represented by compounds 2-(4-aryliminophenoxy)-N-arylacetamide (4a-g). through , reaction with some primary aromatic

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7

Kmal, Rafid Q., Shaimaa A. Behget, and Meaad N. Husean. "Synthesis and Characterization of Formazan Derivatives from Schiff’s Base and Studying their Biological Activity." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 02 (2022): 782–88. http://dx.doi.org/10.25258/ijddt.12.2.56.

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A group of substituted formazine derivatives was prepared through several steps where the first step was the preparation of compound (1) by reacting chloroacetyl chloride with 2-aminopyrimidine, and the second step was the reaction of compound (1) with hydrazine hydrate to obtain the derivative (2) and in the third step was prepared Schiff’s base (3) by reaction of derivative (2) with para-dimethyl benzaldehyde and then a number of formazine derivatives were synthesized by reaction of derivative (3) with a number of substituted aromatic amines. The newly prepared derivatives are distinguished

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8

Zaki, Remon M., Adel M. Kamal El-Dean, Shaban M. Radwan, and Ahmed F. Saber. "Efficient synthesis, reactions and spectral characterization of pyrazolo[4’,3’:4,5]thieno[3,2-d] pyrimidines and related heterocycles." Heterocyclic Communications 25, no. 1 (2019): 39–46. http://dx.doi.org/10.1515/hc-2019-0004.

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AbstractNew pyrazolothienopyrimidines were synthesized. The key intermediate 4-aminothieno[2,3-c]pyrazole-5-carbonitrile 1 was converted to the chloroacetyl amino derivative 2 followed by nucleophilic substitution and Dimorth rearrangement upon treatment with nitrogen nucleophiles to give the pyrimidinones 3a-c. Treatment of 3a with formaldehyde and with triethyl orthoformate afforded the respective tetracyclic derivatives 4 and 5. Condensation of the amino group in the o-aminocarbonitrile 1 with triethyl orthoformate followed by cycloaddition reaction with hydrazine led to the formation of py

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9

Patel, H. S., H. D. Desai, and H. J. Mistry. "Synthesis and Antimicrobial Activity of Some New Piperazine Derivaties Containing Aryl Sulfonyloxy Group." E-Journal of Chemistry 1, no. 2 (2004): 93–98. http://dx.doi.org/10.1155/2004/732420.

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NovelN-substituted piperazine derivatives containing sulfonyloxy aniline moiety have been prepared. The various 4-sulfonyloxy aniline (SA) derivatives (2a-h) have been prepared by the condensation reaction ofN-Acetyl Sulfanilyl chloride (ASC) and sodium phenates followed by hydrolysis. The SA derivatives are then reacted with chloro acetyl chloride to give corresponding (N-Chloroacetyl) derivatives (3a-h). These derivatives are then reacted withN-phenyl piperazine to yield the corresponding piperazine derivatives (4a-h).

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10

Ammar Ferman Abbood, Ahmed M. Abdula, and Younis Baqi. "New Benzimidazoles Bearin 2-Pyrazoline Moiety: Synthesis and Antimicrobial Activity." Journal of Wasit for Science and Medicine 14, no. 3 (2023): 1–12. http://dx.doi.org/10.31185/jwsm.401.

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A new series of 5-(1H-Benzimidazol-2-yl)-4,5-dihydro-1H-pyrazol-3-yl] derivatives (1-9) were synthesized and characterized using spectral analysis. The first step includes the reaction of benzimidazole-2-carboxaldehyde with the o,p-aminoacetophenone to obtain the chalcone derivative (1, 2). The cyclization reaction of chalcone by the hydrazine hydrate afforded compound (3, 4), which represents the starting material for Schiff base derivatives. New Schiff bases (5-6) were synthesized from the reaction of benzimidazole derivative (2) with the corresponding benzaldehydes. The azetidin-2-one (7) a

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11

Al-muamin, Thanaa, Naeemah Al-lami, Suroor Rahman, and Rana Ali. "Synthesis, Characterization and Antimicrobial Activity of New Nucleoside Analogues from Benzotriazole." Chemistry & Chemical Technology 10, no. 3 (2016): 271–78. http://dx.doi.org/10.23939/chcht10.03.271.

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Novel derivatives of 1-(´1, ´3, ´4, ´6-tetra benzoyl-β-D-fructofuranosyl)-1H- benzotriazole and 1-(´1, ´3, ´4, ´6-tetra benzoyl-β-D-fructofuranosyl)-1H-benzotriazole carrying Schiff bases moiety were synthesised and fully characterised. The protection of D-fructose using benzoyl chloride was synthesized, followed by nucleophilic addition/elimination between benzotriazole and chloroacetyl chloride to give 1-(1- chloroacetyl)-1H-benzotriazole. The next step was condensation reaction of protected fructose and 1-(1-chloroacetyl)-1H-benzotriazole producing a new nucleoside analogue. The novel nucle

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12

Shockravi, Abbas, Shahram Mehdipour-Ataei, and Esmael Rostami. "BINOL Macrocycle Derivatives: Synthesis of New Dinaphthyl Sulfide Aza Oxa Thia Crowns (Lariats)." Journal of Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/598937.

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In this research work, dinaphthyl sulfide diester was prepared from the reaction of 1,1′-thiobis (2-hydroxy naphthalene) and methylchloroacetate. Its aza-macrocyclic derivative was synthesized from the reaction of dinaphthyl sulfide diester and diethylenetriamine. Lariats were prepared from the reaction of chloroamides (four derivatives) and initial macrocycle. Chloroamides were synthesized from the reaction of amines (aniline, benzylamine, 8-amino quinoline and 4-amino azobenzene) and chloroacetyl chloride. All the materials were identified by IR,1H NMR,13C NMR, and mass spectroscopies, and e

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13

OKA, Tatsushi, and Kazuyuki MORIHARA. "Inactivation of papain with chloroacetyl amino acid derivatives." Agricultural and Biological Chemistry 50, no. 2 (1986): 519–20. http://dx.doi.org/10.1271/bbb1961.50.519.

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14

Oka, Tatsushi, and Kazuyuki Morihara. "Inactivation of Papain with Chloroacetyl Amino Acid Derivatives." Agricultural and Biological Chemistry 50, no. 2 (1986): 519–20. http://dx.doi.org/10.1080/00021369.1986.10867417.

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15

Ogurtsova, D. N., I. V. Palamarchuk, and I. Kulakov. "Synthesis of monothiooxamide derivatives based on chloroacetamides of 3-aminopyridin-2(1n)-ones." BULLETIN of the L.N. Gumilyov Eurasian National University. Chemistry. Geography. Ecology Series 139, no. 2 (2022): 28–32. http://dx.doi.org/10.32523/2616-6771-2022-139-2-28-32.

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On the basis of biologically active 3-aminopyridine-2(1H)-ones, the authors carried out chemical modification into derivatives of the corresponding monothiooxamides for the first time. It has been shown that monothiooxamides of 3-aminopyridin-2(1H)-oneenter into transamidation reactions with hydrazine-hydrate and are further cyclized under the action of chloroacetyl chloride into conjugated 1,3,4-thiadizole derivatives.

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16

Abdelgawad, Mohamed A., Mohammad M. Al-Sanea, Mohamed A. Zaki, et al. "New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation." Journal of Chemistry 2021 (March 3, 2021): 1–11. http://dx.doi.org/10.1155/2021/6631868.

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Background. Benzoxazole derivatives have different biological activities. In pursuit of designing novel chemical entities with antiprotozoal and antimicrobial activities, benzoxazolyl aniline was utilized as a privileged scaffold of a series of (3-benzoxazole-2-yl) phenylamine derivatives, 3-benzoxazoloyl acetamide, and butyramide derivatives. Methods. These novel analogs were synthesized in straightforward simple chemistry without any quantitative chromatographic separations in reasonable yields. The biological evaluation of all target compounds as potential antimalarial, antileishmanial, ant

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17

Journal, Baghdad Science. "Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives." Baghdad Science Journal 12, no. 3 (2015): 546–54. http://dx.doi.org/10.21123/bsj.12.3.546-554.

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New series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material. The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j). The synthesized Schiff bases were cyclized by chloroacetyl chloride in the presence of triethylamine to form beta-lactam derivatives 3(a-j). The compounds were characterized by deremination melting point, FT-IR and 1H NMR. The beta-lactam derivatives were screened in vitro antibacterial against some bacterial species

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18

AL-Tamimi, Entesar O., Raad M. Muslih, and Khalida A. Thejeel. "Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives." Baghdad Science Journal 12, no. 3 (2015): 546–54. http://dx.doi.org/10.21123/bsj.2015.12.3.546-554.

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New series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material. The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j). The synthesized Schiff bases were cyclized by chloroacetyl chloride in the presence of triethylamine to form beta-lactam derivatives 3(a-j). The compounds were characterized by deremination melting point, FT-IR and 1H NMR. The beta-lactam derivatives were screened in vitro antibacterial against some bacterial species

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19

AL-ALAAF, Hiba Ameen, and Mohammed A. AL-IRAQI. "Synthesis of Some New Hydrazones from Quinazolinone Moiety." Eurasia Proceedings of Science Technology Engineering and Mathematics 16 (December 31, 2021): 52–56. http://dx.doi.org/10.55549/epstem.1068546.

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Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate (4) is one of the important heterocyclic compounds. It isused as a precursor to synthesis new derivatives of quinazolin-4-one moiety. The compound (4) was synthesized via a series of steps from anthranilic acid. The anthranilic acid was converted to its methyl ester (1) by esterification with methanol under acidic condition. The ester (1) was reacted with chloroacetyl chloride to produce methyl α-chloroacetamido benzoate (2). The chloro compound (2) was converted to the corresponding thiocyanato compound (3) by its reaction with ammonium thiocyanate

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20

S. Hmood, Kasim, and Amer N. Elias. "Synthesis, Characterization, and Antimicrobial Evaluation of New Ceftriaxone Derivatives." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 23, no. 2 (2017): 75–88. http://dx.doi.org/10.31351/vol23iss2pp75-88.

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The present study was designed to synthesize a number of new Ceftriaxone derivatives by its involvement with a series of different amines, through the chemical derivatization of its 2-aminothiazolyl- group into an amide with chloroacetyl chloride, which on further conjugation with these selected amines will produce compounds with pharmacological effects that may extend the antimicrobial activity of the parent compound depending on the nature of these moieties. Ceftriaxone was first equipped with a spacer arm (linker) by the action of chloroacetyl chloride in aqueous medium and then furth

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21

V., H. SHAH, A. CHAUHAN N., and R. PARIKH A. "Studies on Acetamide Derivatives. Part-II. Preparation, Antimicrobial and Anthelmintic Activity of N-Arylaminoacetylbenzimidazole/ sulphadiazine or sulphamethazine and N-Arylbenzimidazol-1-yl/sulphadiazin-4-yl or sulphamethazin-4-yl/ acetamides." Journal of Indian Chemical Society Vol. 64, Nov 1987 (1987): 678–81. https://doi.org/10.5281/zenodo.6236615.

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Department of Chemistry, Saurashtra University, Rajkot 360 005 <em>Manuscript received 24 June 1985, revised 14 July 1987, accepted 18 September 1987</em> We have synthesised <em>N</em>-arylaminoacetylbenzimidazole/sulphadiazine or sulphamethazine by the condensation of <em>N</em>-chloroacetylbenzimidazole or 4-<em>N</em>-chloroacetylsulphadiazine derivatives with different aromatic amines. <em>N</em>-Arylbenzimidazol-1- yl/sulphadiazin-4-yl- or sulphamethazine-4-yl-acetamides were also obtained by the condensation of benzimidazole or sulphadiazine derivatives with<em> N</em>-ch

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22

Bhat, S. S., S. N. MamleDesai, V. Narvekar, S. G. Shingade, P. K. Dighe, and B. S. Biradar. "DESIGN, SYNTHESIS AND EVALUATION OF 6-SUBSTITUTED-4-HYDROXY-1-(2- SUBSTITUTEDACETYL)-3-NITROQUINOLIN-2(1H)-ONES FOR ANTICANCER ACTIVITY." INDIAN DRUGS 56, no. 12 (2019): 20–27. http://dx.doi.org/10.53879/id.56.12.11967.

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The present work deals with the synthesis of a series of 6-substituted-4-hydroxy-1-(2-substitued alicyclicaminoacetyl)-3-nitroquinolin-2(1H)-one {IVa-d (1-3)} derivatives and evaluation of their in vitro anticancer activity. Docking study was carried out using EGFR-tyrosine kinase binding site (PDB ID: 1m17) and revealed encouraging results. The sequence of reactions consists of the initial synthesis of 6-substituted 4-hydroxyquinolin-2(1H)-ones (Ia-d), which were further subjected to nitration reaction to give 6- substituted-4-hydroxy-3-nitroquinolin-2(1H)-one (IIa-d). Condensation of compoun

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23

Raauf, Ayad M. R. "Synthesis, Characterization and Biological Activity of New Mefenamic acid - Oxoazetidine Derivatives." Al Mustansiriyah Journal of Pharmaceutical Sciences 13, no. 1 (2013): 75–81. http://dx.doi.org/10.32947/ajps.v13i1.181.

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Several new oxoazetidine derivatives based on mefenamic acid were synthesized via a four steps method in good yields.1st step was prepared 2-[2-chloro-N-(2,3- dimethylphenyl)acetamido]benzoic acid (2) by condensation of mefenamic acid with chloroacetyl chloride, which on amination with hydrazine hydrate in ethanol to give 2-[N- (2,3-dimethylphenyl)-2-hydrazinylacetamido] benzoic acid (3) in good yields(2nd step).Compound 3, on condensation with various aldehydes afforded a series of Schiff bases 2-[N- (2,3-dimethylphenyl)-2-(2-arylhydrazinyl)acetamido]benzoic acid (4a-f) (3rd step).A series of

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24

Çimen, Zeynep, Senem Akkoç, and Zülbiye Kökbudak. "Reactions of aminopyrimidine derivatives with chloroacetyl and isophthaloyl chlorides." Heteroatom Chemistry 29, no. 4 (2018): e21458. http://dx.doi.org/10.1002/hc.21458.

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25

Zaki, Remon M., Adel M. Kamal El Dean, Maisa I. Abd El Monem, and Mohamed A. Seddik. "Novel synthesis and reactions of pyrazolyl-substituted tetrahydrothieno[2,3-c]isoquinoline derivatives." Heterocyclic Communications 22, no. 2 (2016): 103–9. http://dx.doi.org/10.1515/hc-2015-0204.

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AbstractTreatment of isoquinolinecarboxamide 4a with triethyl orthoformate, chloroacetyl chloride or carbon disulfide afforded the pyrimidinone 7, oxopyrimidinethione 12 and chloromethylpyrimidinone 18, respectively. These products were used as versatile starting materials for synthesis of other heterocyclic compounds. The heterocyclic hydrazide 6 was also obtained.

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26

Hanoon, H. D., H. A. Abd Al Hussain, and S. K. Abass. "Synthesis and characterization of azetidin-2-one and 1,3-oxazepine derivatives using Schiff bases derived from 1,1’-biphenyl-4,4’-diamine." Journal of Physics: Conference Series 2063, no. 1 (2021): 012010. http://dx.doi.org/10.1088/1742-6596/2063/1/012010.

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Abstract The present study included the synthesis of two series of heterocyclic compounds, azetidin-2-one and 1,3-oxazepine derivatives. All synthesized compounds were characterized using FT-IR and 1H NMR spectra. The study was divided into two parts. The first synthesis Schiff bases derivatives (1-4) via the condensation reaction of 1,1′-biphenyl-4,4′-diamine (A) with benzaldehyde derivatives (2,5-dimethoxybenzaldehyde, 4-hydroxy-3-methoxybenzaldehyde, furan-2-carbaldehyde and 3-hydroxybenzaldehyde). The second synthesis azetidine-2-one derivatives (5-8) from the reaction of Schiff bases with

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27

KRISHNA, C. JOSHI, N. PATHAK VIJAY, and K. GOYAL MAHENDRA. "Mass and 13C Nmr Spectral Studies of some 1,5-Di- and 1 ,3,5-Trisubstituted Fluorine-containing Hydantoins." Journal of Indian Chemical Society Vol. 66, Nov 1989 (1989): 806–9. https://doi.org/10.5281/zenodo.6105977.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004 <em>Manuscript received 10 November 1988, accepted 26 June 1989</em> The mass spectral decomposition modes of various hydantoin derivatives containing C-5 fluoroaryl, N-aryl, N-3 dialkylaminomethyl, N-3 chloroacetyl and N-3 dialkylaminoacetyl substituents have been investigated. <sup>13</sup>C nmr spectral studies of some of the representative compounds have also been discussed.

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28

Farah Smaysem and Ahmed Salim. "Synthesis and Characterization of Some Heterocyclic Compounds and Evaluation of Antibacterial Activity." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 2068–78. http://dx.doi.org/10.26452/ijrps.v11ispl4.4421.

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In this study, heterocyclic compounds with two nitrogen atoms are prepared by reaction of 2-aminobenzimidazole with formic acid to get amide derivatives (A), reacts with phenylhydrazine to get phenyl hydrazone derivatives (B), reacts with ethyl chloroacetate to obtain ethyl acetate derivatives (C). The derivative (D) obtains on heating in a basic medium. The (B) reacts with 2-chloroacetyl chloride to give derivatives (E). A number of Schiff bases are prepared (F, I) from reacting 2-aminobenzimidazole with benzaldehyde derivatives. The(F) reacts with propargyl bromide to give propargyl bromide

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29

Neelgundmath, Mahabaleshwaraiah, and Oblennavar Kotresh. "Synthesis, Evaluation and Characterization of Some 1,3,4-Triazole-2-one Derivatives as Antimicrobial Agents." E-Journal of Chemistry 9, no. 4 (2012): 2407–14. http://dx.doi.org/10.1155/2012/672125.

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A series of novel compounds like 3[(phenyl substituted)-5-methyl-1(Benzosulphonylamine)]-1,3,4-triazole-2-ones II(a-f) were synthesized by treating 4-amino-1-phenyl-3-methyl-5-oxo-1,2,4-triazoles with benzene sulphonyl chloride using pyridine as solvent. Similarly by using 4-amino-1-aryl-3-methyl-5-oxo-1,2,4-triazoles and acetic anhydride as starting material 3[(phenyl substituted)-5-methyl-1(acetylamino)]-1,3,4-triazole-2-ones III(a-f) were synthesized and also 3[(phenyl substituted)-5-methyl-1(chloroacetyl)]-1,3,4-triazole-2-ones I(a-f) were synthesized by treating 4-amino-1-aryl-3-methyl-5-

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30

Prakash, Ram, R. B. Singh, R. K. Vishnoi та K. Srivastava. "Synthesis, Characterization and biological activity of some novel heterocyclic β-lactam/thiazol compounds derived from 4-phenyl-4,5-dihydrothiazol-2-yl-imino". Research Journal of Chemistry and Environment 27`, № 10 (2023): 115–21. http://dx.doi.org/10.25303/2710rjce1150121.

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An efficient and convenient synthesis of β-lactam/ thiazol derivatives has been achieved by the reaction of acetophenone, substituted aromatic aldehyde and thiourea yield substituted schiff’s bases which further undergo the cyclization in the presence of chloroacetyl chloride, triethyl amine/ZnCl2, thioglycoolic acid. All the synthesized novel derivatives have been established by % of C, N, S elements, FT-IR, 1H NMR and Mass spectral studies. Further in-vitro antimicrobial activity of novel derivatives was carried out against some Gram-positive and Gram-negative bacteria by serial dilution met

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31

Mohammed Kamil Hadi, Maadh Qusay Abdulkadir, Mohammed Abdulameer Oleiwi, Sarah Ahmed, and Zainab Dhia Kamms. "Synthesis, Characterization and Preliminary Antimicrobial Study of Some New Ether and Thioether Derivatives of Sulfadiazine." Iraqi Journal of Pharmaceutical Sciences 34, no. 1 (2025): 176–84. https://doi.org/10.31351/vol34iss1pp176-184.

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A new series of ether and thioether derivatives of sulfadiazine (T1-T3 and E1-E3) have been synthesized from reaction of sulfadiazine with chloroacetyl chloride and the resultant compounds treated with different phenols and thiols. The structures of target ether and thioether derivatives were confirmed depending on their analytical and spectral data. The antimicrobial effect of the final derivatives has been tested in vitro with gram-positive and gram-negative bacteria and candida albicans. The antibacterial activity of the target compounds after three days of incubation demonstrated that all

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32

D’Souza, Malcolm J., Zoon Ha Ryu, Byoung-Chun Park та Dennis N. Kevill. "Correlation of the rates of solvolysis of acetyl chloride and α-substituted derivatives". Canadian Journal of Chemistry 86, № 5 (2008): 359–67. http://dx.doi.org/10.1139/v08-028.

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Additional specific rates of solvolysis have been determined for acetyl chloride and diphenylacetyl chloride. These are combined with literature values to carry out correlation analyses, using the extended Grunwald–Winstein equation with incorporation of literature values for solvent nucleophilicity (NT) and solvent ionizing power (YCl). Parallel analysis are carried out using literature values for the specific rates of solvolysis of trimethylacetyl chloride, chloroacetyl chloride, phenylacetyl chloride, and α-methoxy-α-trifluoromethylphenylacetyl chloride (MTPAC). Chloroacetyl chloride and MT

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33

Vashi, Kamal, and H. B. Naik. "Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity." E-Journal of Chemistry 1, no. 5 (2004): 272–75. http://dx.doi.org/10.1155/2004/158924.

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A series of Compound 4-(2᾽-hydroxy-3᾽-chloro-5᾽-ethyl phen-1᾽-yl)-1-(4᾽-tolyl)-3-chloro-2-azetidinone 4a-j have been prepared by the reaction of 2 -hydroxy-3 -chloro-5 -ethyl-N-(p-tolyl)-chalconimines 3a-j with chloroacetyl chloride in the presence of triethylamine. The Schiff base derivatives 3a-j has been prepared by the condensation of different substituted chalone derivatives 1 with p-toluidine 2. The synthesized compounds were screened for their antibacterial activity againstStaphylococcus aureusandEscherichia coli.

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34

Lin, Tsau-Yen, and David W. Kuo. "Inactivation of Human Fibroblast Collagenase by Chloroacetyl N-Hydroxypeptide Derivatives." Journal of Enzyme Inhibition 5, no. 1 (1991): 33–40. http://dx.doi.org/10.3109/14756369109069058.

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35

KRISHNA, C. JOSHI, N. PATHAK VIJAI, and K. GOYAL MAHENDRA. "Mass and 13C Nmr Spectral Studies of some 1,5-Di- and 1,3,5-Trisubstituted Fluorine-containing Hydantoins." Journal of Indian Chemical Society Vol. 66, Nov 1989 (1989): 806–9. https://doi.org/10.5281/zenodo.6076692.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004 <em>Manuscript received 10 November 1988, accepted 26 June 1989</em> <strong>The mass spectral decomposition modes of various hydantoin derivatives containing C-5 fluoroaryl, N-aryl, N-3 dialkylaminomethyl, N-3 chloroacetyl and N-3 dialkylaminoacetyl substituents have been investigated. <sup>12</sup>C nmr spectral studies of some of the representative compounds have also been discussed.</strong>

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36

Mustafa Taha Abdull, Monther F. Mahdi, and Ayad k. Khan. "Molecular docking, Synthesis and Characterization of New Indomethacin and Mefenamic Acid Analogues as Potential Anti-inflammatory Agents." Al Mustansiriyah Journal of Pharmaceutical Sciences 23, no. 3 (2023): 336–44. http://dx.doi.org/10.32947/ajps.v23i3.1052.

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In this work the pharmacological study and synthesis of new thiadiazine bearing on triazole which obtained from hippuric acid , indomethacin and mefenamic acid that have carboxylic acid moiety, Drugs with carboxylic groups and thiocarbohydrazide interacted to produce the 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol (1a-c). and the starting products 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol) were treated with chloroacetyl chloride to produce final products (2a-c). To confirm the structure of the generated compounds, FT-IR, 1H-NMR, and mass spectroscopy were used to characterize all derivatives

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37

M., B. HOGALE, K. SALUNKHE V., and S. KACHARE D. "Preparation of 5-Methyl-N-propylamino- 2,3-dihydroindole Derivatives." Journal of Indian Chemical Society Vol. 66, Jul 1989 (1989): 484–86. https://doi.org/10.5281/zenodo.6223842.

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Department of Chemistry, Shivaji University, Kolhapur-416 004 <em>Manuscript received 8 April 1987, revised 26 July 1988,accepted 23 May 1989</em> Preparation of 5-Methyl-<em>N</em>-propylamino-  2,3-dihydroindole Derivatives

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38

S., S. SANDHU, SINGH JASWlNDER, and SHARMA SANJAY. "Spectral Study of some N-Acyldipeptides and their Derivatives." Journal Of Indian Chemical Society Vol. 66, Feb 1989 (1989): 104–5. https://doi.org/10.5281/zenodo.6302299.

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Department of Chemistry, Guru Nanak Dev University, Amritsar-148 005 <em>Manuscript received 21 September 1987, revised 21 ]uly 1988, accepted 18 November 1988</em> The <em>N</em>-acyldlpeptides, such as (<em>N</em>-formyl, <em>N-</em>aeetyl, <em>N</em>-benzoyl, <em>N</em>-chloroacetyl, <em>N</em>-trlfiuoroacetyl) L-pheny lalanylglyeine, and their etbylesters were prepared and characterised. The effect of different substituents on a particular group have been studied using <sup>13</sup>C nmr spectral data.  

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39

S., S. SANDHU, SINGH JASWINDER, and SHARMA SANJAY. "Spectral Study of some N-Acyldipeptides and their Derivatives." Journal of Indian Chemical Society Vol. 66, February 1989 (1989): 104–5. https://doi.org/10.5281/zenodo.5948729.

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Department of Chemistry, Guru Nanak Dev University, Amritsar-148 006 Manuscript <em>received 21 September 1987, revised 21 July 1988, accepted 18 November 1988</em> <strong>The <em>N</em>-acyldipeptides, such as (<em>N</em>-formyl, <em>N</em>-acetyl, <em>N</em>-henzoyl, <em>N</em>-chloroacetyl. <em>N</em>-trifluoroacety1)-<sub>L</sub>-phenyialanylglycine, and their ethylesters were prepared and characterised. The effect of different substituents on a particular group have been studied using <sup>12</sup>C nmr spectral data</strong>

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40

KRISHNA, C. JOSHI, N. PATHAK VIJAI, and K. GOYAL MAHENDRA. "Mass and 13C Nmr Spectral Studies of some 1,5-Di- and 1,3,5-Trisubstituted Fluorine-containing Hydantoins." Journal of Indian Chemical Society Vol. 66, November 1989 (1989): 806–9. https://doi.org/10.5281/zenodo.6010194.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004 <em>Manuscript received 10 November 1988, accepted 26 June 1989</em> <strong>The mass spectral decomposition modes of various hydantoin derivatives containing C-5 fluoroaryl, N-aryl, N-3 dialkylaminomethyl, N-3 chloroacetyl and N-3 dialkylaminoacetyl substituents have been investigated. <sup>11</sup>C nmr spectral studies of some of the representative compounds have also been discussed.</strong>

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41

Kamal, Ahmed, and Shaimaa Adnan. "Synthesis, Characterization and Study the Biological Activity for Some New Heterocyclic Derivative from 4,5-dichloro Imidazole." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1542–46. http://dx.doi.org/10.25258/ijddt.12.4.10.

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Creating a multi-step method for synthesizing heterocyclic compounds is the goal of this research. The first step involves reacting 4,5-dichloro-2- phenylenediamine with 3- amino- 4-“hydroxybenzoic acid to produce an imidazole derivative (1), which then reacts with salicyldehyde to produce the azo compound (2). Two, a Schiff base derivative is produced via a reaction with p-chloro aniline (23). Final steps involve reactions (3) with chloroacetyl chloride, alanine, sodium azide, thioglycol acid, anthranilic acid, and maleic anhydride, yielding beta-lactam derivatives (4), imidazolidine (5), tet

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42

Wameed Raad Abd-allah and Khaled Mtani Al – Janabi. "Preparation and diagnosis of new picolinic acid derivatives." Tikrit Journal of Pure Science 23, no. 6 (2023): 101–10. http://dx.doi.org/10.25130/tjps.v23i6.679.

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In this study, a new series of heterocyclic rings derived from picolinic acid was prepared. The quaternary reaction of acid hydrazone with chloroacetyl chloride was intended to obtain the azitidine-2-on ring known as beta-lactam and the preparation of the seventh ring of acid hydrazone reaction with the anhydride and phthalic anhydride To obtain a 3.1-oxabine loop. The five-ring of the picolinic acid hydrazide reaction with CS2 was also destined to obtain a 4,3,1-oxadiazole-2-thaion ring. The new compounds were diagnosed using FT-IR techniques and resonance technique Nuclear Magnetic H-NMR and

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43

Tank, Manishkumar Jinabhai, Navinkumar A. Kucha, Chirag G. Naik, Tina R. Barot, and G. M. Malik. "Adamantane-pyrido[2,3-d]pyrimidine Derivatives; Synthesis, Characterization and Investigation of Antimicrobial Study." Oriental Journal Of Chemistry 39, no. 2 (2023): 393–402. http://dx.doi.org/10.13005/ojc/390219.

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Target molecules based on Adamantane-pyrido[2,3-d]pyrimidine derivatives were prepared. Adamantane-pyrido[2,3-d]pyrimidine series using N-(hydroxyadamantan-1-yl)-5-(2,4-substitutedphenyl)-2-Methyl-4-Oxo-7-(2-oxo-2H-Chromen-3-yl)pyrido[2,3-d]Pyrimidine-3(4H)carboxamide (6a-j) was synthesized by reaction between 3-(2-chloroacetyl)-5-(2,4-substitutedphenyl)-2-Methyl-7-(2-Oxo-2H-Chromen-3-yl) pyrido[2,3-d]pyrimidin-4(3H)-one (5a-j) and 3-aminoadamantan-1-ol. These derivatives of Adamantane-pyrido[2,3-d]Pyrimidine were investigated in vitro for their biological characteristics against the strains w

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44

Mohsen Ibrahim, Youssef, and Muna Ismael Khalaf. "SYNTHESIS AND CHARACTERIZATION OF SOME HETEROCYCLIC COMPOUNDS DERIVED FROM METOCLOPRAMIDE DRUG AND MEASUREMENT of BIOLOGICAL ACTIVITY." iraqi journal of market research and consumer protection 16, no. 1 (2024): 248–60. http://dx.doi.org/10.28936/jmracpc16.1.2024.(21).

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This study included the synthesis of some new Schiff bases and heterocyclic compounds [1‐6] from the reaction of metoclopramide with some aromatic aldehydes by the classical Schiff method, then the Schiff bases were treated with chloroacetyl chloride and thioglycolic acid to obtain cyclic derivatives of beta-lactams [5,6] and 4-thiazolidinone [3,4], respectively. These derivatives were characterized by their melting points by FT IR, 1H NMR. Some compounds prepared were evaluated for their antioxidant activity by oxidation with 2,2-diphenyl-1-picrylhydryl (DPPH). Comparison of the antioxidant a

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45

Journal, Baghdad Science. "Synthesis of New Some Imidazole Derivatives Containing ?-Lactam Ring." Baghdad Science Journal 13, no. 2 (2016): 307–16. http://dx.doi.org/10.21123/bsj.13.2.307-316.

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In this work 5-methylene-yl - (2-methy –oxazole-4-one) (1H) imidazole (1) were synthesized from the reaction of L-Histidine with acetic anhydride and which converted to the of 5-methylene-yl-(2-methyl 3-amino imidazole-4-one)-1H-imidazole (2) by reaction with hydrazine hydrate. Schiff bases (3-6) were synthesized from the reaction of compound (2) with different aromatic aldehyde. Reaction of compounds (3-6) with chloroacetyl chloride gives azetidinone one derivatives (7-10). These compounds were characterized by FT-IR and some of them with 1H-NMR and 13C-NMR spectroscopy.

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46

S., Guru, Yadav R., Srivastava Soumya, K. Srivastava S., and D. Srivastava S. "Synthesis of some new N1-[(2-oxo-3-chloro-4-aryl-azitidin)-(acetyl amino)]-indole derivatives and their pharmacological activity." Journal of Indian Chemical Society Vol. 83, Dec 2006 (2006): 1236–124. https://doi.org/10.5281/zenodo.5834026.

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Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H. S. Gour University, Sagar-470 003, Madhya Pradesh, India <em>E-mail </em>: professorsks@rediffmail.com <em>Manuscript received 17 March 2006, revised 25 July 2006, accepted 7 September 2006</em> Indole on reaction with chloroacetyl chloride afforded N<sup>1</sup>-(1-chloro acetyl)-indole which was renuxed with hydrazine hydrate to give <em>N</em><sup>1</sup>-[(1-hydrazino)acetyl]-indole. The hydrazino derivative of indole was further treated with various substituted aromatic carbonyls to get <em>N</em><sup>1</sup>-[(benzyl

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47

El-Ablack, Fawzia Zakaria. "Synthesis of Some New Benzimidazole Derivatives of Pharmaceutical Interest." E-Journal of Chemistry 8, no. 2 (2011): 748–52. http://dx.doi.org/10.1155/2011/723421.

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Reaction of 2-(aminomethyl)benzimidazole dihydrochloride (1) with ethyl acetoacetate was studied to give diazepinone-benzimidazole derivative (2), while, treatment of 1 with phenylhydrazono ethylacetoacetate afforded phenylhydrazino diazepinone derivative (3). On the other hand, reaction of 1 with acetyl acetone resulted in the formation of diazepine derivative (4). The reaction of 1 with ethyl cyanoacetate was studied to give 3-aminodiazepinone derivative (5). Also the reaction of 1 with acetophenone and/or benzophenone has been investigated to give the fused imidazolines 6 and 7 respectively

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48

Bhat, Ishwar, Sunil Chaithanya, P. D. Satyanarayana, and Balakrishna Kalluraya. "The synthesis and antimicrobial study of some azetidinone derivatives with the para-anisidine moiety." Journal of the Serbian Chemical Society 72, no. 5 (2007): 437–42. http://dx.doi.org/10.2298/jsc0705437b.

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Azetidinones were synthesized from p-anisidine in two steps. First the Schiff's bases were prepared by reacting the hydrazide of an anisidine derivative with different aromatic aldehydes. Cyclocondensation of the Schiff's bases with chloroacetyl chloride in the presence of triethylamine resulted in the formation of the corresponding azetidinone analogues. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR and mass spectroscopic analysis. The antibacterial and antifungal potential of the synthesized compounds were evaluated by the agar disc method.

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49

Deeb, Ali, Besher Bayoumy, Fathy Yasine, and Rida Fikry. "Pyridazine Derivatives and Related Compounds, Part 4. Pyrrolo[2,3-c]pyridazines and Furo[2,3-c]pyndazines, Synthesis and Some Reactions." Zeitschrift für Naturforschung B 47, no. 3 (1992): 418–23. http://dx.doi.org/10.1515/znb-1992-0320.

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Ethyl 5-amino-3,4-diphenyl-7H-pyrrolo[2,3-c]pyridazine-6-carboxylate (1), ethyl 5-aminofuro[ 2,3-c]pyridazine-6-carboxylate (2) and 5-aminofuro[2,3-c]pyridazine-6-carboxamide (3), are obtained from 4-cyano-5,6-diphenyl-3(2H)-pyridazinone. 5-Acetamido and 5-chloroacetamido derivatives prepared from 1, undergo cyclization on heating to form 2-substituted pyridazino[4',3':4,5]pyrrolo[3,2-d]oxazin-4(5H)-one (5a, b). The reaction of 1 and 2 with hydrazine gave 6-carbohydrazide derivatives (7 a, b). Compound 3 undergoes condensation with acetyl chloride, chloroacetyl chloride, benzoyl chloride, form

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50

Qu, Fan-Zhi, Ya-Fei Liu, Jia-Qing Cao, et al. "Novel 25-hydroxyprotopanaxadiol derivatives incorporating chloroacetyl chloride and their anti-tumor evaluation." Bioorganic & Medicinal Chemistry Letters 24, no. 23 (2014): 5390–94. http://dx.doi.org/10.1016/j.bmcl.2014.10.050.

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