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Journal articles on the topic 'Chlorobenzamido'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Hasana, Ani Riani, Siswandono Siswandono, and Marcellino Rudyanto. "Synthesis and characterization of 2-Benzamido-NBenzylbenzamide Derivative." JURNAL ILMU KEFARMASIAN INDONESIA 20, no. 2 (2022): 281. http://dx.doi.org/10.35814/jifi.v20i2.1135.

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Anthranilamide derivatives exhibit anti-inflammatory, antipyretic, antibacterial, antiangiogenic, and anticoagulant properties. With an early in silico examination of its analgesic capabilities, this study aimed to generate a novel anthranilamide molecule by altering 2-Benzamido-N-Benzylbenzamide. Modification of anthranilamide with 1/2/3-chloro benzoyl chloride by acylation resulted in the design, synthesis, characterization, and research of the analgesic effects of 2-benzamido-N-benzoylbenzamide derivatives. 2-(2-chlorobenzamido)-N-(2-chlorobenzoyl)benzamide, 2-(3-chlorobenzamido)-N-(3-chlor

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2

Yadav, Bishwa Nath, Shambhu Prasad, and Satya Murti Prasad. "Methyl 2-(2-chlorobenzamido)benzoate." Acta Crystallographica Section E Structure Reports Online 58, no. 11 (2002): o1198—o1199. http://dx.doi.org/10.1107/s160053680201807x.

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3

Khan, Islam Ullah, Onur Şahin, Rashid Javaid, Shahzad Sharif, and Orhan Büyükgüngör. "Methyl 2-(4-chlorobenzamido)benzoate." Acta Crystallographica Section E Structure Reports Online 66, no. 12 (2010): o3338. http://dx.doi.org/10.1107/s160053681004897x.

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4

Ouahrouch, Abdelaaziz, Moha Taourirte, Hassan B. Lazrek, Mohamed El Azhari, Mohamed Saadi, and Lahcen El Ammari. "Methyl 2-(3-chlorobenzamido)benzoate." Acta Crystallographica Section E Structure Reports Online 68, no. 12 (2012): o3400—o3401. http://dx.doi.org/10.1107/s1600536812046934.

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5

Breznica-Selmani, Pranvera, Kristina Mladenovska, Zoran Kavrakovski, Bozhana Mikhova, Gerald Draeger, and Emil Popovski. "[(3-Chlorobenzamido)methyl]triethylammonium Chloride." Molbank 2015, no. 2 (2015): M851. http://dx.doi.org/10.3390/m851.

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6

Khan, Zulfiqar Ali, Khalid M. Khan, and Shazia Anjum. "2-(2-Chlorobenzamido)benzoic acid." Acta Crystallographica Section E Structure Reports Online 63, no. 10 (2007): o4103. http://dx.doi.org/10.1107/s1600536807044352.

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7

Khan, Islam Ullah, Muneeb Hayat Khan, Muhammad Nadeem Arshad, and Mehmet Akkurt. "2-(4-Chlorobenzamido)acetic acid." Acta Crystallographica Section E Structure Reports Online 67, no. 4 (2011): o916. http://dx.doi.org/10.1107/s1600536811009536.

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8

Brandy, Yakini, Ray J. Butcher, Tolulope A. Adesiyun, Solomon Berhe, and Oladapo Bakare. "2-Chloro-3-(4-chlorobenzamido)-1,4-naphthoquinone." Acta Crystallographica Section E Structure Reports Online 65, no. 1 (2008): o64. http://dx.doi.org/10.1107/s1600536808040993.

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9

Moreno-Fuquen, Rodolfo, Vanessa Melo, and Javier Ellena. "Crystal structure of 2-(4-chlorobenzamido)benzoic acid." Acta Crystallographica Section E Crystallographic Communications 71, no. 11 (2015): o856—o857. http://dx.doi.org/10.1107/s2056989015017879.

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In the title molecule, C14H10ClNO3, the amide C=O bond isantito theo-carboxy substituent in the adjacent benzene ring, a conformation that facilitates the formation of an intramolecular amide-N—H...O(carbonyl) hydrogen bond that closes anS(6) loop. The central amide segment is twisted away from the carboxy- and chloro-substituted benzene rings by 13.93 (17) and 15.26 (15)°, respectively. The most prominent supramolecular interactions in the crystal packing are carboxylic acid-H...O(carboxyl) hydrogen bonds that lead to centrosymmetric dimeric aggregates connected by eight-membered {...HOC=O}2s

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10

M., M. DUTTA, N. GOSWAMI B., and C. S. KATAKY J. "Studies on Biologically Active Heterocycles. Part-III. Synthesis and Antibacterial Activity of some 2-Aryl/ Aralkyl-3-substituted-4-thiazolidinones." Journal of Indian Chemical Society Vol. 67, April 1990 (1990): 332–34. https://doi.org/10.5281/zenodo.6163457.

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Regional Research Laboratory, Jorhat-785 006 <em>Manuscript received 30 January 1989, revised 24 July 1989, accepted 21 November 1989</em> A series of new 2-aryl/aralkyl-3-[2,4·dichlorobenzamido]-4-thiazolidinones and 2-aryl/aralkyl-3-[2-chlorobenzamido]-4-thiazolidinones have been synthesised by con- densation of the respective hydrazones with mercaptoacetic acid. The hydrazones have been prepared by condensing different aromatic and aliphatic aldehydes with the corresponding acylhydrazides. All the compounds were screened for their antibacterial activity.

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11

Zhang, Dehua, Xiaoyan Zhang, and Lijuan Guo. "(Z)-Ethyl 3-(4-chlorobenzamido)-2-cyano-3-(4-fluorophenyl)acrylate." Acta Crystallographica Section E Structure Reports Online 65, no. 1 (2008): o90. http://dx.doi.org/10.1107/s1600536808041469.

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12

Li, Ru Lin, Lin Wang, and Gang Xue. "Study on Preparation, Biological Activity and Thermal Decomposition of N-Benzoyl-N＇-(4-Chlorobenzamido) Thiourea." Advanced Materials Research 236-238 (May 2011): 1914–18. http://dx.doi.org/10.4028/www.scientific.net/amr.236-238.1914.

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A novel compound N-benzoyl-N＇-(4-chlorobenzamido) thiourea was prepared from benzoyl isothiocyanate which was obtained from benzoyl chloride and potassium thiocyanate, and 4-chlorobenzoyl hydrazine which was obtained from ethyl 4-chlorobenzoate and hydrazine hydrate. IR,1H NMR,13C NMR and elemental analysis were utilized to determine the structure of the thiourea. The biological tests indicated that the target compound had antibacterial activity against bacillus subtilis and taphylo-coccus aurers. Meanwhile, the thermal stability was investigated by thermogrativity（TG） and differential thermog

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13

Zhang, Xiao-Hong, Ping Zhong, Zhi-Ping Yang, Mao-Lin Hu, and Hong-Ping Xiao. "5-(2-Chlorobenzamido)-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile." Acta Crystallographica Section E Structure Reports Online 61, no. 4 (2005): o806—o807. http://dx.doi.org/10.1107/s1600536805005763.

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14

Chen, Chun-Yi, Hua-Yu Hsieh, Jyh-Horung Chen, Shin-Shin Wang, Jo-Yu Tung, and Lian-Pin Hwang. "Two-stage formation of chloro (N-o-chlorobenzamido-meso-tetraphenylporphyrinato) zinc(II) methylene chloride solvate: Zn(N-NHCO(o-Cl)C6H4-tpp)Cl·CH2Cl2." Polyhedron 26, no. 15 (2007): 4602–8. http://dx.doi.org/10.1016/j.poly.2007.06.021.

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15

Medici, Antonio, Giovanni Luongo, Lucio Previtera, Daniele Naviglio, Giovanni Di Fabio, and Armando Zarrelli. "Degradation of Indomethacin in Wastewater: Removal with Sodium Hypochlorite and Analysis of Degradation Byproducts." Molecules 30, no. 10 (2025): 2180. https://doi.org/10.3390/molecules30102180.

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Over the years, the frequent and continuous use of drugs has led to a high presence of emerging micropollutants in wastewater, increasing environmental and health concerns. Among these chemicals, Indomethacin (IND), a widely used anti-inflammatory drug, has been detected up to 150 ng/L in water bodies. Its presence in aquatic environments causes increasing concerns due to its high persistence, limited biodegradability, and resistance to conventional treatment processes. This study examined the degradation of IND via oxidation with sodium hypochlorite (NaClO) and the characterization of the deg

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16

Fernández, M. J., M. S. Toledano, E. Gálvez, et al. "Structural, conformational, theoretical and pharmacological study of some amides derived from 3,7-dimethyl-9-[(N-substituted)-4-chlorobenzamido]3,7-diazabicyclo[3.3.1]nonane-9-carboxamide." Journal of Molecular Structure 351 (June 1995): 137–46. http://dx.doi.org/10.1016/0022-2860(94)08489-5.

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17

Sayedul Islam, Md, and Md Abu Sayid Mia. "A Highly Active Catalyst 2,4,6‐Tris (di‐4‐chlorobenzamido)‐1,3,5‐triazine Palladium (II) Chloride for the Green Synthesis of Substituted Dihydrobenzo[ b ]thiophene in Ionic Liquid." ChemistrySelect 5, no. 46 (2020): 14632–42. http://dx.doi.org/10.1002/slct.202003674.

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18

Wisnu, Elok Dea Orens Ubung, Indah Purnama Sary, and Dwi Koko Pratoko. "Sintesis dan Uji Aktivitas Antibakteri Senyawa N-fenil-4-klorobenzamida." Pustaka Kesehatan 6, no. 2 (2018): 212. http://dx.doi.org/10.19184/pk.v6i2.7569.

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N-phenylbenzamide is benzamide derivatives, which is potential as an antibacterial agent. N-phenyl-4-chlorobenzamide is N-phenylbenzamide derivative that substitued by chloro to the para position and it was expected to enhance the antibacterial activity. N-phenyl-4-chlorobenzamide was synthesized by reacting 1,3-diphenyilthiourea and 4-chlorobenzoil chloride. This compound has been purified and provided 53% of product with crystal shape, white color, and melting point of 195-197 oC. The purification of this compound was confirmed by TLC and the structure was identified by 1H-NMR, 13C-NMR, and

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19

Saeed, Aamer, Rasheed Ahmad Khera, Naeem Abbas, Jim Simpson, and Roderick G. Stanley. "N-Butyl-4-chlorobenzamide." Acta Crystallographica Section E Structure Reports Online 64, no. 12 (2008): o2322—o2323. http://dx.doi.org/10.1107/s1600536808036313.

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20

Xing, Zhi-Tao, Wei-Lin Ding, Hai-Bo Wang, Jun Yin, and Feng Han. "2-Chlorobenzamide oxime monohydrate." Acta Crystallographica Section E Structure Reports Online 63, no. 2 (2007): o1019—o1020. http://dx.doi.org/10.1107/s1600536807004114.

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21

Zheng, Xi, Bo Li, Qiang Wang, and Li Guo. "N-Benzylcarbamothioyl-2-chlorobenzamide." Acta Crystallographica Section E Structure Reports Online 66, no. 7 (2010): o1774. http://dx.doi.org/10.1107/s1600536810023822.

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22

Chen, Kwan-Tin, Ming Yang Tsai, Jyh-Horung Chen, Shin-Shin Wang, and Jo-Yu Tung. "Metal complexes of N-o-chlorobenzamido-meso-tetraphenylporphyrin: cis-Tl(N-NCO(o-Cl)C6H4-tpp)(OAc) and trans-Cd(N-NHCO(o-Cl)C6H4-tpp)(OAc) (tpp=5, 10, 15, 20-tetraphenylporphyrinate)." Inorganic Chemistry Communications 13, no. 4 (2010): 506–10. http://dx.doi.org/10.1016/j.inoche.2010.01.022.

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23

Khawar Rauf, M., Michael Bolte, and Amin Badshah. "N-(Benzothiazol-2-yl)-3-chlorobenzamide." Acta Crystallographica Section E Structure Reports Online 65, no. 6 (2009): o1245. http://dx.doi.org/10.1107/s1600536809016481.

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The title molecule, C14H9ClN2OS, exists in the solid state in its amide form with a typical C=O bond length, as well as shortened C—N bonds. The plane containing the HNCO atoms subtends dihedral angles of 12.3 (4) and 8.1 (3)° with the planes of the phenyl ring and benzothiazole group, respectively, whereas the dihedral angle between the planes of the phenyl ring and the benzothiazole group is 5.96 (6)°. In the crystal, molecules form intermolecular N—H...N hydrogen bonds, generating independent scissor-likeR22(8) dimers.

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24

Ghare, Sakshi. "Synthesis of 2-chloro-benzamides for evaluation antimicrobial and disinfectant activity: Part-I." Current Trends in Pharmacy and Pharmaceutical Chemistry 6, no. 1 (2024): 26–27. http://dx.doi.org/10.18231/j.ctppc.2024.009.

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2-Chlorobenzamide derivatives have been synthesized and claimed in this research study. The compound SG1 and SG2 were synthesized by known methods Ethylene diamine and isopropyl amine was dissolved in ethanolic 1 N NaOH separately and to it 2-Chlorobenzoyl chloride was added. The products SG1 and SG2 were collected respectively.

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25

Ramesh, Balu, and Masilamani Jeganmohan. "Cobalt(iii)-catalyzed redox-neutral [4+2]-annulation of N-chlorobenzamides/acrylamides with alkylidenecyclopropanes at room temperature." Chemical Communications 57, no. 30 (2021): 3692–95. http://dx.doi.org/10.1039/d1cc00654a.

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An efficient synthesis of substituted 3,4-dihydroisoquinolinones through [4+2]-annulation of N-chlorobenzamides/acrylamides with alkylidenecyclopropanes using a less expensive and air stable Co(iii) catalyst is demonstrated.

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26

Qingxiang, Zhou, Lu Wenying, Liu Guoguang, and Xue Xiuling. "Study on the Hydrolysis of 2-Chlorobenzamide." Journal of Agricultural and Food Chemistry 48, no. 6 (2000): 2572–75. http://dx.doi.org/10.1021/jf990163a.

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27

COŞMAN, Sertaç. "Experimental Research of the Effects of Benzoylthiourea Derivative Fuel and Gasoline Mixtures on Engine Performance and Emissions." International Journal of Automotive Science and Technology 7, no. 4 (2023): 403–9. http://dx.doi.org/10.30939/ijastech..1397506.

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In this study, the influences of Benzoylthiourea Derivative Fuel N-(2-amino-5-bromo-1,dihydropyridine-1-yl)carbonothioyl)-2-chlorobenzamide as an additive into gas-oline were researched on engine performance and exhaust emissions. For this reason, a single-cylinder four stroke gasoline engine was run at wide open throttle, and 2400, 2800, 3200, 3600 and 4000 rpm engine speeds. The changes of engine torque, power output, specific fuel consumption, thermal efficiency, CO, CO2 and HC emissions were experi-mentally investigated.

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28

Cockcroft, Jeremy K., Asma B. M. Buanz, Anastasia Ntantou, et al. "Polymorphism in 2-Chlorobenzamide: Run of the Mill or Not?" Crystal Growth & Design 16, no. 11 (2016): 6144–47. http://dx.doi.org/10.1021/acs.cgd.6b00973.

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29

Schoenleber, A., P. Pattison, and G. Chapuis. "Structure and phase transition ofp-chlorobenzamide described in the superspace formalism." Acta Crystallographica Section A Foundations of Crystallography 58, s1 (2002): c183. http://dx.doi.org/10.1107/s0108767302092358.

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30

Skibiński, Robert, and Łukasz Komsta. "Application of Curve Resolution Algorithms in the Study Drug Photodegradation Kinetics—The Example of Moclobemide." Journal of AOAC INTERNATIONAL 95, no. 3 (2012): 708–12. http://dx.doi.org/10.5740/jaoacint.sge_skibinski.

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Abstract The photodegradation of moclobemide was studied in methanolic media. Ultra-HPLC (UHPLC)/MS/MS analysis proved decomposition to 4-chlorobenzamide as a major degradation product and small amounts of Ro 16-3177 (4-chloro-N-[2-[(2-hydroxyethyl)amino] ethyl]benzamide) and 2-[(4-chlorobenzylidene)amino]-N-[2-ethoxyethenyl]ethenamine. The methanolic solution was investigated spectrophotometrically in the UV region, registering the spectra during 30 min of degradation. Using reference spectra and a multivariate chemometric method (multi- variate curve resolution-alternating least squares), th

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31

B., Thimme Gowda, C. Mary M., and Jyothi K. "Kinetics and mechanism of oxidation of thiosemicarbazide by substituted-N-chlorobenzamides in aqueous methanol medium." Journal of Indian Chemical Society Vol. 78, Aug 2001 (2001): 407–11. https://doi.org/10.5281/zenodo.5878491.

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Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri-574 199, India <em>E-mail</em> : gowdabt@yahoo.com  <em> Fax </em>: 91-824-7423671742424 Manuscript received 18 October 2000, accepted 22 March 2001 The kinetics of oxidation of thiosemicarbazide by <em>N</em>-chlorobenzamide, <em>N</em>-chloro-<em>p</em>-methyl-, <em>N</em>-chloro-<em>p</em>-chloro- and <em>N</em>-chloro-<em>p</em>-nitrobenzamides have been studied in aqueous methanol in the presence of perchloric acid. The reactions show first order kinetics in [oxidant], fractiona

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32

Hempel, Andrew, Norman Camerman, Donald Mastropaolo, and Arthur Camerman. "A monoamine oxidase B inhibitor:N-(2-aminoethyl)-p-chlorobenzamide (Ro16-6491) hydrochloride." Acta Crystallographica Section E Structure Reports Online 61, no. 7 (2005): o2283—o2285. http://dx.doi.org/10.1107/s1600536805019008.

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33

Sow, Salif, Felix Odame, Ngoné Diouf, et al. "Syntheses and X-ray Structure of N-(Benzothiazol-2-yl)-3-chlorobenzamide." International Research Journal of Pure and Applied Chemistry 25, no. 4 (2024): 1–9. http://dx.doi.org/10.9734/irjpac/2024/v25i4861.

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The reaction of 3-chloro-benzoyl chloride and 2-aminobenzothiazole in the presence of potassium thiocyanate yielded a yellowish solid C15H10ClN3OS2 (1). Reaction of 1 with cobalt chloride yield a yellowish solid C14H11ClN2O2S (2) which gives crystal suitable for X-ray analyses. The compounds were characterized by elemental analyses FTIR spectroscopy and melting point measurement. Compound 2 crystallizes in the triclinic space group Pī with the following parameters: a = 7.0299(2) Å b = 7.0466(2) Å c = 14.5490(2) Å a = 103.844(3)° β = 92.929(2)° g = 107.291(3) V = 662.33(4) Å3 Z= 2 R1 = 0.030 wR

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34

Chakravarty, Akhil R., F. Albert Cotton, and Derek A. Tocher. "Synthesis and structure of a binuclear ruthenium 4-chlorobenzamidato complex." Polyhedron 4, no. 6 (1985): 1097–102. http://dx.doi.org/10.1016/s0277-5387(00)84088-7.

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35

Farook, N. A. Mohamed, and G. A. Seyed Dameem. "Kinetics of Oxidation of 3-Benzoylpropionic Acid byN-Chlorobenzamide in Aqueous Acetic Acid Medium." E-Journal of Chemistry 8, no. 2 (2011): 561–64. http://dx.doi.org/10.1155/2011/697973.

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The kinetics of oxidation of 3-benzoylpropionic acid(KA)byN-chlorobenzamide(NCB)in aqueous acetic acid medium in the presence of perchloric acid have been investigated. The observed rate of oxidation is first order dependence each in[KA],[NCB]and [H+]. The main product of the oxidation is the corresponding carboxylic acid. The rate decreases with the addition of benzamide, one of the products of the reaction. Variation in ionic strength of the reaction medium has no significant effect on the rate of oxidation. But the rate of the reaction is enhanced by lowering the dielectric constant of the

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36

Djinović, K., M. Globokar, and P. Zupet. "Structure of bezafibrate (2-{p-[2-(p-chlorobenzamide)ethyl]phenoxy}-2-methylpropanoic acid)." Acta Crystallographica Section C Crystal Structure Communications 45, no. 5 (1989): 772–75. http://dx.doi.org/10.1107/s0108270188013459.

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37

Muniraj, Nachimuthu, and Kandikere Ramaiah Prabhu. "Cobalt(III)-Catalyzed [4 + 2] Annulation of N-Chlorobenzamides with Maleimides." Organic Letters 21, no. 4 (2019): 1068–72. http://dx.doi.org/10.1021/acs.orglett.8b04117.

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38

Shang, Ruo-Feng, Si-Jie Liu, Yu Liu, and Jian-Ping Liang. "Crystal structure of 14-O-[(2-chlorobenzamide-2-methylpropane-2-yl) thioacetate] Mutilin, C33H46ClNO5S." Zeitschrift für Kristallographie - New Crystal Structures 228, no. 4 (2013): 473–75. http://dx.doi.org/10.1515/ncrs.2013.0220.

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39

Shang, Ruo-Feng, Jian-Ping Liang, and Wen-Zhu Guo. "Crystal structure of 14-O-[(3-chlorobenzamide-2-methylpropane-2-yl) thioacetate] Mutilin, C33H46ClNO5S." Zeitschrift für Kristallographie - New Crystal Structures 228, no. 1 (2013): 135–37. http://dx.doi.org/10.1524/ncrs.2013.0068.

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40

Kubo, Atsushi, Ryuichi Ikeda, and Daiyu Nakamura. "Structural Phase Transition and Molecular Motion of p-Chlorobenzamide as Studied by the Temperature Variations of 35Cl NQR Frequencies, Chlorine Nuclear Quadrupolar Relaxation Times, and 1H Magnetic Dipolar Relaxation Times." Zeitschrift für Naturforschung A 41, no. 1-2 (1986): 270–74. http://dx.doi.org/10.1515/zna-1986-1-248.

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The temperature dependences of 35Cl NQR frequencies, 35Cl (37Cl) nuclear quadrupolar relaxation times (T1ClQ), 1H NMR absorption, and of 1H NMR relaxation times were observed for p-chlorobenzamide, p-ClC6H4CONH2 and its N-deuterated analog. The existence of three 35Cl NQR lines already reported was confirmed for the known low temperature phase below 316 K. A single sharp 35Cl NQR line was detected in the high temperature phase up to 447 K just below the melting point 451 K. At lower temperatures, three different 35Cl T1ClQ values attributable to the fluctuation of the electric field gradient d

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41

SURESH, P. NAYAK, and THIMME GOWDA B. "Oxidation of Thiosemicarbazide, its Metal Complex and Hydrazones by N-Chlorobenzamide in Aquo-acetic Acid Medium-A Kinetic and Mechanistic Study." Journal of Indian Chemical Society Vol. 69, Oct 1992 (1992): 637–41. https://doi.org/10.5281/zenodo.6018509.

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Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri-574 199 <em>Manuscript received 14 August 1991, revised 17 June 1992, accepted 22 July 1992</em> The kinetics of oxidation of thiosemicarbazide (TSC), its zinc metal complex and hydrazones by <em>N</em>-chlorobenzamide (NCB) have been investigated in aquo-acetic acid (1 : 1, v/v) medium in the presence of perchloric acid. The hydrazones studied are benzaldehyde, propionaldehyde, acetone and acetophenone thiosemicarbazones. The oxidations follow first order kinetics in [NCB], fractional order d

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42

M. Salih, Kezhal, and Hashim J. Azeez. "Synthesis and Spectral Characterization of a New Series of N-4-Chlorobenzamide-5- phenylthiazolidin-3-one." Rafidain Journal of Science 27, no. 1 (2018): 15–28. http://dx.doi.org/10.33899/rjs.2018.141182.

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43

Zhao, Fengwu, and Guirong Wang. "Crystal structure of 14-O-[(4-chlorobenzamide-2-methylpropane-2-yl)-thioacetate] mutilin diethanol solvate, C37H58ClNO7S." Zeitschrift für Kristallographie - New Crystal Structures 228, no. 3 (2013): 422–24. http://dx.doi.org/10.1524/ncrs.2013.0154.

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44

Edwards, M. R., William Jones, and W. D. Samuel Motherwell. "Cocrystal formation of 4-methyl and 4-chlorobenzamide with carboxylic acids: Chloro/methyl interchange and crystal structure." CrystEngComm 8, no. 7 (2006): 545. http://dx.doi.org/10.1039/b607423e.

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45

Rameshwar, N., K. Krishna, B. Ashok Kumar, and T. Parthasarathy. "QSAR studies of N1-(5-chloro-2-pyridyl)-2-{[4-(alkyl methyl)benzoyl]amino}-5-chlorobenzamide analogs." Bioorganic & Medicinal Chemistry 14, no. 2 (2006): 319–25. http://dx.doi.org/10.1016/j.bmc.2005.07.058.

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46

Ahmed, Atteeque, Aamer Saeed, Omar M. Ali, et al. "Exploring Amantadine Derivatives as Urease Inhibitors: Molecular Docking and Structure–Activity Relationship (SAR) Studies." Molecules 26, no. 23 (2021): 7150. http://dx.doi.org/10.3390/molecules26237150.

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This article describes the design and synthesis of a series of novel amantadine-thiourea conjugates (3a–j) as Jack bean urease inhibitors. The synthesized hybrids were assayed for their in vitro urease inhibition. Accordingly, N-(adamantan-1-ylcarbamothioyl)octanamide (3j) possessing a 7-carbon alkyl chain showed excellent activity with IC50 value 0.0085 ± 0.0011 µM indicating that the long alkyl chain plays a vital role in enzyme inhibition. Whilst N-(adamantan-1-ylcarbamothioyl)-2-chlorobenzamide (3g) possessing a 2-chlorophenyl substitution was the next most efficient compound belonging to

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Cabezas, N., M. Martinez, E. Galvez, M. S. Arias, F. Florencio та S. Garcia-Blanco. "Synthesis and structural study of N-(8-isopropyl-nortropan-3-α-yl)-2-methoxy-4-amino-5-chlorobenzamide". Journal of Molecular Structure 172 (лютий 1988): 381–94. http://dx.doi.org/10.1016/0022-2860(88)87030-3.

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Nayak, Suresh P., and B. Thimme Gowda. "Kinetics and mechanisms of oxidation of thiosemicarbazide, its metal complex and hydrazones byN-chlorobenzamide in water methanol medium." Journal of Physical Organic Chemistry 5, no. 11 (1992): 755–63. http://dx.doi.org/10.1002/poc.610051108.

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Y., Dominic Ravichandran, Kishor Rachna, Hariharasubramanian A., Mohana Priya K., and S. Khora Samanta. "Synthesis and characterization of N-substituted benzimidazole derivatives and study of their antibacterial and antifungal activity." Journal of Indian Chemical Society Vol. 92, Jun 2015 (2015): 915–17. https://doi.org/10.5281/zenodo.5637656.

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Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore-632 014, Tamilnadu, India <em>E-mail </em>: dominic.y@vit.ac.in Medical Biotechnology Division, School of Bioscience and Technology, VIT University, Vellore-632 014, Tamilnadu, India N-(4-(1<em>H</em>-Benzo[d]imidazol-1-yl)phenyl)-3-nitrobenzamide, N-(4-(1<em>H</em>-benzo[d]imidazol-1-yl)phenyl)-4- chlorobenzamide, 4-(1<em>H</em>-benzo[d]imidazol-1-yl)benzenamine and N-(4-(1<em>H</em>-benzo[<em>d</em>]imidazol-1-yl)phenyl)-4-bromobenzamide were synthesized and characterized by IR and NMR techniques. These N-substi

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Kesuma, Dini, Tegar Achsendo Yuniarta, Alfiani Damayanti Suherto, Galih Satrio Putra, Sutrisno Sutrisno, and Farida Anwari. "Synthesis, molecular docking, molecular dynamics, pharmacokinetics prediction and bioassay of N-(phenylcarbamothioyl)-4-chlorobenzamide as anti-breast cancer candidate." Journal of Pharmacy & Pharmacognosy Research 13, no. 2 (2025): 551–64. http://dx.doi.org/10.56499/jppres24.2092_13.2.551.

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Context: Breast cancer ranks as the leading cause of mortality among women in Indonesia. Thiourea is a compound containing sulfur atom and nitrogen in which its chemical structure resembles urea compound, which has been applied as an anticancer, such as hydroxyurea, nitrosourea, 5-fluorouracil, and sorafenib. Aims: To develop anticancer candidates as a new compound of thiourea derivative, N-(phenylcarbamothioyl)-4-chloro-benzamide (4-Cl-PCTB). Methods: The compound was synthesized from phenylthiourea and 4-chloro-benzoyl chloride by applying nucleophilic acyl substitution reactivity. The compo

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