Relevant bibliographies by topics / Chloroquine resistance

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Academic literature on the topic 'Chloroquine resistance'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Chloroquine resistance"

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de Bruijn, M. H. L. "Chloroquine resistance." Parasitology Today 5, no. 10 (1989): 326. http://dx.doi.org/10.1016/0169-4758(89)90125-7.

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Edaye, Sonia, Dagobert Tazoo, D. Scott Bohle, and Elias Georges. "3-Halo Chloroquine Derivatives Overcome Plasmodium falciparum Chloroquine Resistance Transporter-Mediated Drug Resistance in P. falciparum." Antimicrobial Agents and Chemotherapy 59, no. 12 (2015): 7891–93. http://dx.doi.org/10.1128/aac.01139-15.

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ABSTRACTPolymorphism in thePlasmodium falciparumchloroquine resistance transporter (PfCRT) was shown to cause chloroquine resistance. In this report, we examined the antimalarial potential of novel 3-halo chloroquine derivatives (3-chloro, 3-bromo, and 3-iodo) against chloroquine-susceptible and -resistantP. falciparum. All three derivatives inhibited the proliferation ofP. falciparum; with 3-iodo chloroquine being most effective. Moreover, 3-iodo chloroquine was highly effective at potentiating and reversing chloroquine toxicity of drug-susceptible and -resistantP. falciparum.
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Chen, Nanhua, Dennis E. Kyle, Cielo Pasay, et al. "pfcrt Allelic Types with Two Novel Amino Acid Mutations in Chloroquine-Resistant Plasmodium falciparum Isolates from the Philippines." Antimicrobial Agents and Chemotherapy 47, no. 11 (2003): 3500–3505. http://dx.doi.org/10.1128/aac.47.11.3500-3505.2003.

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ABSTRACT Mutations in the pfcrt and pfmdr1 genes have been associated with chloroquine resistance in Plasmodium falciparum. Ten and five mutations, respectively, have been identified in these genes from chloroquine-resistant parasites worldwide. Mutation patterns in pfcrt revealed that chloroquine resistance evolved independently in southeast Asia, South America, and Papua New Guinea. However, the evolution of chloroquine resistance in the rest of the Pacific region is unclear. In this study, we examined sequence polymorphisms in these genes in isolates from Morong, Philippines, and compared t
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Lim, Pharath, Sophy Chy, Frédéric Ariey, et al. "pfcrt Polymorphism and Chloroquine Resistance in Plasmodium falciparum Strains Isolated in Cambodia." Antimicrobial Agents and Chemotherapy 47, no. 1 (2003): 87–94. http://dx.doi.org/10.1128/aac.47.1.87-94.2003.

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ABSTRACT Plasmodium falciparum chloroquine resistance was first detected in Cambodia in the early sixties. Treatment with chloroquine was abandoned 20 years ago. In vitro chloroquine sensitivity monitoring indicates that all eastern Cambodian isolates were sensitive to chloroquine, whereas most isolates collected from western provinces displayed reduced susceptibility to chloroquine. This indicates that the rate of chloroquine resistance remains high and stable in this region in the absence of chloroquine pressure. Characterization of codons 72 to 78 and 218 to 220 of pfcrt revealed six distin
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Shafik, Sarah Heckmatt, Sashika Natasha Richards, Ben Corry, and Rowena Elizabeth Martin. "Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT." PLOS Biology 20, no. 5 (2022): e3001616. http://dx.doi.org/10.1371/journal.pbio.3001616.

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Polymorphisms in the Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene and the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene alter the malaria parasite’s susceptibility to most of the current antimalarial drugs. However, the precise mechanisms by which PfMDR1 contributes to multidrug resistance have not yet been fully elucidated, nor is it understood why polymorphisms in pfmdr1 and pfcrt that cause chloroquine resistance simultaneously increase the parasite’s susceptibility to lumefantrine and mefloquine—a phenomenon known as collateral drug sensitivity
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Lehane, Adele M., and Kiaran Kirk. "Chloroquine Resistance-Conferring Mutations in pfcrt Give Rise to a Chloroquine-Associated H+ Leak from the Malaria Parasite's Digestive Vacuole." Antimicrobial Agents and Chemotherapy 52, no. 12 (2008): 4374–80. http://dx.doi.org/10.1128/aac.00666-08.

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ABSTRACT Chloroquine resistance in the malaria parasite Plasmodium falciparum is conferred by mutations in the P. falciparum chloroquine resistance transporter (PfCRT). PfCRT localizes to the membrane of the parasite's internal digestive vacuole, an acidic organelle in which chloroquine accumulates to high concentrations and exerts its toxic effect. Mutations in PfCRT are thought to reduce chloroquine accumulation in this organelle. How they do so is the subject of ongoing debate. Recently we have shown that in the presence of chloroquine there is an increased leak of H+ from the digestive vac
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Ridley, Robert G. "Malaria: Dissecting chloroquine resistance." Current Biology 8, no. 10 (1998): R346—R349. http://dx.doi.org/10.1016/s0960-9822(98)70218-0.

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Adagu, I. S., W. N. Ogala, D. J. Carucci, M. T. Duraisingh, and D. C. Warhurst. "Field chloroquine-resistance determinants." Annals of Tropical Medicine & Parasitology 91, sup1 (1997): S107—S111. http://dx.doi.org/10.1080/00034983.1997.11813248.

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ADAGU, I. S. "Field chloroquine resistance determinants." Annals of Tropical Medicine And Parasitology 91, no. 2 (1997): 107–12. http://dx.doi.org/10.1080/00034989761391.

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Ridley, R. G., W. Hofheinz, H. Matile, et al. "4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum." Antimicrobial Agents and Chemotherapy 40, no. 8 (1996): 1846–54. http://dx.doi.org/10.1128/aac.40.8.1846.

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We have synthesized several 4-aminoquinolines with shortened side chains that retain activity against chloroquine-resistant isolates of Plasmodium falciparum malaria (W. Hofheinz, C. Jaquet, and S. Jolidon, European patent 94116281.0, June 1995). We report here an assessment of the activities of four selected compounds containing ethyl, propyl, and isopropyl side chains. Reasonable in vitro activity (50% inhibitory concentration, < 100 nM) against chloroquine-resistant P. falciparum strains was consistently observed, and the compounds performed well in a variety of plasmodium berghei animal
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Dissertations / Theses on the topic "Chloroquine resistance"

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Tesfaselassie, Elias Sibhatu. "Antimalarial Drug Discovery using Triazoles to Overcome Chloroquine Resistance." PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2506.

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Malaria is considered as one of the most prevalent and debilitating diseases affecting humans. Plasmodium falciparum is the most virulent form of the parasite which developed resistance to several antimalarial drugs. Chloroquine is one of the most successful antimalarials developed that is safe, effective, and cheap. However, its use has been limited due to the emergence of drug resistance. Click chemistry, particularly, the copper(I)-catalyzed reaction between azides and alkynes has shown to have a cutting-edge advantage in medicinal chemistry by its reliability, selectivity and biocompatibil
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How, Cheong Wen How Chan. "Paludisme chloroquinorésistant : à propos de 17 observations de chloroquinorésistance clinique observées entre 1986 et 1988." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR1M181.

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Yvette, Mofenge Opute. "Novel adamantane-chloroquinolin conjugates to overcome plasmodium falciparum chloroquine resistance." University of the Western Cape, 2017. http://hdl.handle.net/11394/5930.

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Magister Scientiae - MSc (Pharmaceutical Chemistry)<br>Malaria poses devastating health and socioeconomic outcomes on global health especially among pregnant women and children below the age of 5 in endemic areas. This is exacerbated by Plasmodium falciparum resistance to available antimalarial drugs, especially chloroquine (CQ), which was the drug of choice for many years against the blood stage of malaria.
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Boulter, Matthew K. "Aspects of chloroquine resistance and its reversal in Plasmodium falciparum." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240437.

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Jehl, Patrick. "Mécanismes de la chloroquinorésistance chez "Plasmodium falciparum" : intérêt de l'étude de la multirésistance des cellules cancéreuses." Paris 5, 1989. http://www.theses.fr/1989PA05P070.

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Johnson, David James. "Studies on the molecular basis of chloroquine resistance in Plasmodium falciparum." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273985.

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Jambou, Ronan. "Evaluation des antipaludeens en zone de chloroquinoresistance recente : republique du cameroun." Nice, 1989. http://www.theses.fr/1989NICE6568.

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GAILLARD, JOELLE. "La chloroquinoresistance du paludisme en afrique : a propos d'observations recemment etudiees a toulouse." Toulouse 3, 1988. http://www.theses.fr/1988TOU31275.

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Bot, Ba Njock Simon. "Chloroquine chez l'enfant impalude : étude de la pharmacocinétique et réponses clinique et parasitologique compte tenu des conditions du terrain." Paris 5, 1991. http://www.theses.fr/1991PA05P080.

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Chatain, Guillaume C. "Towards an understanding of hemozoin formation and chloroquine resistance in Plasmodium falciparum." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81609.

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Malaria is a worldwide disaster that is still killing two million lives annually. The recent rise of the epidemic is mainly attributed to the emergence of resistance to the most effective, affordable and safe antimalarial, chloroquine. Unfortunately, neither the mechanism of action of these 4-aminoquinolines nor the basis of chloroquine resistance is well understood. It has been noted that a known channel blocker, verapamil, is able to modulate chloroquine resistance.<br>In this study, a chemical biology approach was taken to gain some light into these mechanisms. The design, synthesis
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Books on the topic "Chloroquine resistance"

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Lee, Andrew Hojin. Investigating mutability and the plasmodium falciparum chloroquine resistance transporter in drug resistant malaria parasites. [publisher not identified], 2016.

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Kim, Jonathan Young. Structural Investigation of Plasmodium falciparum Chloroquine Resistance Transporter in the Context of Anti-Malarial Drug Resistance. [publisher not identified], 2019.

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Book chapters on the topic "Chloroquine resistance"

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Krogstad, D. J., P. H. Schlesinger, and I. Y. Gluzman. "Susceptibility and Resistance of Plasmodium falciparum to Chloroquine." In Handbook of Experimental Pharmacology. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74095-4_3.

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Kumar, Pawan, and Indira Ghosh. "Probing with Pharmacophore Modeling the Chloroquine Resistance and Designing Novel Antimalarials." In Biophysical and Computational Tools in Drug Discovery. Springer International Publishing, 2021. http://dx.doi.org/10.1007/7355_2021_131.

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Martiney, James A., Angel S. Ferrer, Anthony Cerami, Sergey Dzekunov, and Paul Roepe. "Chloroquine Uptake, Altered Partitioning and the Basis of Drug Resistance: Evidence for Chloride-Dependent Ionic Regulation." In Novartis Foundation Symposium 226 - Transport and Trafficking in the Malaria-Infected Erythrocyte. John Wiley & Sons, Ltd., 2007. http://dx.doi.org/10.1002/9780470515730.ch18.

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Moran, J. S., and K. W. Bernard. "Chloroquine-Resistant Malaria in West Africa." In Travel Medicine. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73772-5_21.

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Hodoameda, Peter. "P. falciparum and Its Molecular Markers of Resistance to Antimalarial Drugs." In Plasmodium Species and Drug Resistance [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98372.

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The use of molecular markers of resistance to monitor the emergence, and the spread of parasite resistance to antimalarial drugs is a very effective way of monitoring antimalarial drug resistance. The identification and validation of molecular markers have boosted our confidence in using these tools to monitor resistance. For example, P. falciparum chloroquine resistance transporter (PfCRT), P. falciparum multidrug resistance protein 1 (PfMDR1), P. falciparum multidrug kelch 13 (pfk13), have been identified as molecular markers of resistance to chloroquine, lumefantrine, and artemisinin respec
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Wirth, Dyann F., and Alan Cowman. "Mechanisins of drug resistance in protozoan parasites." In Molecular Biology of Parasitic Protozoa. Oxford University PressOxford, 1996. http://dx.doi.org/10.1093/oso/9780199636020.003.0010.

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Abstract Drug resistance in microorganisms is an increasing problem in world health today. Commonly used antimicrobial agents are no longer effective and the rate at which resistance develops, often to multiple drugs, has increased the urgency for a solution to this problem. Drug-resistant strains have been found among almost all infectious organisms from viruses to multicellular parasitic nematodes. The impact of drug-resistant infectious diseases on world health is just beginning to be assessed. Certain antimicrobial agents are no longer usable as resistance is so widespread. An example of t
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Tsegaye Tseha, Sintayehu. "Plasmodium Species and Drug Resistance." In Plasmodium Species and Drug Resistance [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98344.

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Malaria is a leading public health problem in tropical and subtropical countries of the world. In 2019, there were an estimated 229 million malaria cases and 409, 000 deaths due malaria in the world. The objective of this chapter is to discuss about the different Plasmodium parasites that cause human malaria. In addition, the chapter discusses about antimalarial drugs resistance. Human malaria is caused by five Plasmodium species, namely P. falciparum, P. malariae, P. vivax, P. ovale and P. knowlesi. In addition to these parasites, malaria in humans may also arise from zoonotic malaria parasit
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Goodman, Catherine. "Choosing the first-line drug for malaria treatment—how can cost-effectiveness analysis inform policy?" In The Economics of Infectious Disease. Oxford University PressOxford, 2006. http://dx.doi.org/10.1093/oso/9780198516217.003.0002.

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Abstract Malaria drug policy in Africa is frequently argued to be in, or fast approaching, crisis (Attaran et al. 2004; Institute of Medicine 2004). Malaria is already responsible for over 10% of the total disease burden in sub-Saharan Africa, and its impact is increasing as a result of antimalarial drug resistance. For decades, most countries have relied on chloroquine as their first-line drug for treating uncomplicated malaria, benefiting from its effectiveness, low price and good safety profile. Those days are over because chloroquine resistance is already high in many African countries and
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Garg, Dr Gopal. "Antimalarial Drugs." In Edited Book of Pharmacology-III [According to Latest Syllabus of B. Pharm-VI Semester of Pharmacy Council of India]. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/nbennurphch14.

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Antimalarial drugs are medications used to prevent and treat malaria, a life-threatening disease caused by *Plasmodium* parasites transmitted through the bites of infected Anopheles mosquitoes. These drugs target different stages of the parasite's life cycle, including the liver and blood stages. Common antimalarial drugs include chloroquine, quinine, mefloquine, atovaquone-proguanil, and artemisinin-based combination therapies (ACTs). Chloroquine and mefloquine interfere with the parasite's ability to detoxify heme, a toxic byproduct of hemoglobin digestion. Quinine, a traditional remedy, dis
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Budi Setia Asih, Puji, and Din Syafruddin. "Plasmodium vivax and Drug Resistance." In Plasmodium Species and Drug Resistance [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97320.

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Resistance to antimalarial drugs is a threat to global efforts to eliminate malaria by 2030. Currently, treatment for vivax malaria uses chloroquine or ACT for uncomplicated P. vivax whereas primaquine is given to eliminate latent liver stage infections (a method known as radical cure). Studies on P. vivax resistance to antimalarials and the molecular basis of resistance lags far behind the P. falciparum as in vitro cultivation of the P. vivax has not yet been established. Therefore, data on the P. vivax resistance to any antimalarial drugs are generated through in vivo studies or through moni
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Conference papers on the topic "Chloroquine resistance"

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Jansen, G., RJ Scheper, and B. Dijkmans. "THU0017 Chloroquine resistance in human cem (t) cells is mediated by multidrug resistance protein 1." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.526.

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Konieczna, I., L. Lechowicz, M. Chrzanowska, et al. "AB1319 Drug resistance in bacteria isolated from urine of rheumatoid arthritispatients and induction of resistance by chloroquine." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.5607.

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Jansen, G., RJ Scheper, and B. Dijkmans. "THU0018 Differential chloroquine sensitivity of human cem (t) cells with various mechanisms of resistance to methotrexate." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.527.

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Sultan, Ali A., Devendra Bansal, Fahmi Y. Khan, et al. "Point Mutation in Chloroquine Resistance-Associated Genes (Pfcrt and Pfmdr-1) in Imported Cases of Malaria in Qatar." In Qatar Foundation Annual Research Conference Proceedings. Hamad bin Khalifa University Press (HBKU Press), 2016. http://dx.doi.org/10.5339/qfarc.2016.hbpp2721.

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Rieber, Manuel. "Abstract 4334: Greater resistance of mutant p53 tumor cells to hypoxia or chloroquine with glucose or pyruvate supplementation is diminished under glucose starvation." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4334.

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Dalesio, N., H. Lam, N. Kim, P. L. Zeitlin, S. A. McGrath-Morrow, and S. S. An. "Epithelium and Smooth Muscle from CF Airways Are Resistant to Bitter Taste Receptor-Mediated Relaxation with Chloroquine." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7451.

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Singh, Preeti, Madan Godbole, Geeta Rao, et al. "Abstract B98: Chloroquin converts molecular iodine induced autophagy in MDAMB231 to apoptotic cell death: Implications for overcoming chemotherapeutic resistance." In Abstracts: Frontiers in Cancer Prevention Research 2008. American Association for Cancer Research, 2008. http://dx.doi.org/10.1158/1940-6207.prev-08-b98.

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Reports on the topic "Chloroquine resistance"

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Tesfaselassie, Elias. Antimalarial Drug Discovery using Triazoles to Overcome Chloroquine Resistance. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.2503.

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Kyle, Dennis E., Wilbur K. Milhous, and Richard N. Rossan. Reversal of Plasmodium Falsiparum Resistance to Chloroquine in Panamanian Aotus Monkeys. Defense Technical Information Center, 1993. http://dx.doi.org/10.21236/ada263042.

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San Pedro, Ekaterina Ellyce. A brief historical overview of the antimalarials chloroquine and artemisinin: An investigation into their mechanisms of action and discussion on the predicament of antimalarial drug resistance. Iowa State University, 2021. http://dx.doi.org/10.31274/cc-20240624-10.

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Gunsaru, Bornface. Simplified Reversed Chloroquines to Overcome Malaria Resistance to Quinoline-based Drugs. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.400.

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