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Dissertations / Theses on the topic 'Chloroquine resistance'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Tesfaselassie, Elias Sibhatu. "Antimalarial Drug Discovery using Triazoles to Overcome Chloroquine Resistance." PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2506.

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Malaria is considered as one of the most prevalent and debilitating diseases affecting humans. Plasmodium falciparum is the most virulent form of the parasite which developed resistance to several antimalarial drugs. Chloroquine is one of the most successful antimalarials developed that is safe, effective, and cheap. However, its use has been limited due to the emergence of drug resistance. Click chemistry, particularly, the copper(I)-catalyzed reaction between azides and alkynes has shown to have a cutting-edge advantage in medicinal chemistry by its reliability, selectivity and biocompatibil

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2

How, Cheong Wen How Chan. "Paludisme chloroquinorésistant : à propos de 17 observations de chloroquinorésistance clinique observées entre 1986 et 1988." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR1M181.

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3

Yvette, Mofenge Opute. "Novel adamantane-chloroquinolin conjugates to overcome plasmodium falciparum chloroquine resistance." University of the Western Cape, 2017. http://hdl.handle.net/11394/5930.

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Magister Scientiae - MSc (Pharmaceutical Chemistry)<br>Malaria poses devastating health and socioeconomic outcomes on global health especially among pregnant women and children below the age of 5 in endemic areas. This is exacerbated by Plasmodium falciparum resistance to available antimalarial drugs, especially chloroquine (CQ), which was the drug of choice for many years against the blood stage of malaria.

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4

Boulter, Matthew K. "Aspects of chloroquine resistance and its reversal in Plasmodium falciparum." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240437.

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5

Jehl, Patrick. "Mécanismes de la chloroquinorésistance chez "Plasmodium falciparum" : intérêt de l'étude de la multirésistance des cellules cancéreuses." Paris 5, 1989. http://www.theses.fr/1989PA05P070.

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6

Johnson, David James. "Studies on the molecular basis of chloroquine resistance in Plasmodium falciparum." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273985.

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7

Jambou, Ronan. "Evaluation des antipaludeens en zone de chloroquinoresistance recente : republique du cameroun." Nice, 1989. http://www.theses.fr/1989NICE6568.

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8

GAILLARD, JOELLE. "La chloroquinoresistance du paludisme en afrique : a propos d'observations recemment etudiees a toulouse." Toulouse 3, 1988. http://www.theses.fr/1988TOU31275.

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9

Bot, Ba Njock Simon. "Chloroquine chez l'enfant impalude : étude de la pharmacocinétique et réponses clinique et parasitologique compte tenu des conditions du terrain." Paris 5, 1991. http://www.theses.fr/1991PA05P080.

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10

Chatain, Guillaume C. "Towards an understanding of hemozoin formation and chloroquine resistance in Plasmodium falciparum." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81609.

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Malaria is a worldwide disaster that is still killing two million lives annually. The recent rise of the epidemic is mainly attributed to the emergence of resistance to the most effective, affordable and safe antimalarial, chloroquine. Unfortunately, neither the mechanism of action of these 4-aminoquinolines nor the basis of chloroquine resistance is well understood. It has been noted that a known channel blocker, verapamil, is able to modulate chloroquine resistance.<br>In this study, a chemical biology approach was taken to gain some light into these mechanisms. The design, synthesis

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11

Bray, Patrick Gerrard. "Plasmodium falciparum : studies on the mechanism of chloroquine resistance and its reversal." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316597.

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12

Carlton, Jane M. R. "The genetics of chloroquine resistance in the rodent malaria parasite Plasmodium chabaudi." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/13312.

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The aim of this work has been to use linkage analysis to determine the chromosomal location of genes involved in chloroquine resistance in the rodent malaria parasite <I>Plasmodium chabaudi</I>. The <I>P. chabaudi</I> genome was found to contain 14 chromosomes. A genetic map of each chromosome was made using DNA markers. Most of the markers were known genes from other species of <I>Plasmodium</I>. Other markers were developed by the RAPD-PCR (random amplified polymorphic DNA-polymerase chain reaction) technique, the first time this method has been developed for use with <I>Plasmodium</I> paras

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13

Paguio, Michelle Fortaleza. "Biochemical and biophysical analysis of recombinant Plasmodium falciparum chloroquine resistance transporter (pfcrt)." Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/525210083/viewonline.

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14

VIGUIER, KOURTA MARIE-JEANNE. "Perturbations biologiques au cours du paludisme a plasmodium falciparum chloroquinoresistant." Toulouse 3, 1989. http://www.theses.fr/1989TOU31703.

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15

Gunsaru, Bornface. "Simplified Reversed Chloroquines to Overcome Malaria Resistance to Quinoline-based Drugs." PDXScholar, 2010. https://pdxscholar.library.pdx.edu/open_access_etds/400.

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Malaria is a major health problem, mainly in developing countries, and causes an estimated 1 million deaths per year. Plasmodium falciparum is the major type of human malaria parasite, and causes the most infections and deaths. Malaria drugs, like any other drugs, suffer from possible side effects and the potential for emergence of resistance. Chloroquine, which was a very effective drug, has been used since about 1945, but its use is severely limited by resistance, even though it has mild side effects, and is otherwise very efficacious. Research has shown that there are chloroquine reversal a

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16

Cabrera, Mynthia. "Analysis of the cellular and molecular mechanisms of Chloroquine Resistance in Plasmodium Falciparum." Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/501018382/viewonline.

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17

Noisang, Chaturong. "Molecular detection of drug resistance in Plasmodium vivax." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21781.

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Introduction: Surveillance of drug resistance is essential for early warning systems and to advocate for appropriate drug policies. Many countries experience a high prevalence of antimalarial drug resistance, which threatens malaria control and elimination programs. The molecular methods used to monitor chloroquine resistance in Plasmodium vivax, target a multidrug resistance 1 (Pvmdr1) gene, and a putative transporter protein (Pvcrt-o) gene. Molecular detection of resistance in sulphadoxine-pyrimethamine, which is often accidentally used to treat against P. vivax, has dihydrofolate reductase

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18

Pokomi, Rostand Fankam. "Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities." University of the Western Cape, 2020. http://hdl.handle.net/11394/7950.

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Magister Pharmaceuticae - MPharm<br>Malaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are urgently needed due to the surge in resistance of the Plasmodium falciparum (the parasite that causes malaria in humans) to existing antimalarial drugs. One approach to circumvent the problem of P. falciparum resistance to antimalarial drugs could be the discovery of novel compounds with unique scaffolds and possibly new mechanisms of action.

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19

Ayoun, Anthony-Charles. "La chloroquine ex-panacée du traitement antipaludique peut-elle être remplacée par la pyronaridine ?" Paris 5, 1998. http://www.theses.fr/1998PA05P251.

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20

Modrzynska, Katarzyna Kinga. "Genetics of drug resistance in malaria : identification of genes conferring chloroquine and artemisinin resistance in rodent malaria parasite Plasmodium chabaudi." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/4888.

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Resistance to antimalarial drugs continues to be a major obstacle in controlling and eradicating malaria. The identification of genetic markers of resistance is vital for disease management but they can be difficult to predict before resistance arises in the field. This thesis describes an alternative approach to gene identification, combining an in vivo experimental evolution model, Linkage Group Selection (LGS) and Solexa genome re-sequencing. Here this model was used to resolve the genetic basis of chloroquine and artemisinin resistance in the rodent malaria parasite Plasmodium chabaudi. AS

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21

DECOCQ, FABRICE. "Aspects epidemiologiques et cliniques du paludisme a plasmodium falciparum chloroquino resistant au gabon : a propos d'une etude portant sur 690 non-immuns, sous chloroquinoprophylaxie pendant un sejour de 4 mois et 2 mois apres le retour." Toulouse 3, 1988. http://www.theses.fr/1988TOU31096.

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22

Makowa, Hazel Beverly. "The relationship between the insecticide dichloro-diphenyl-trichloroethane and chloroquine in Plasmodium falciparum resistance." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20310.

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Thesis (MSc)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: Dichloro-diphenyl-trichloroethane (DDT) was extensively used in agriculture pest control and is still used for indoor residual spraying to control malaria. The lipophylicity of DDT and its breakdown product dichloro-diphenyl-dichloroethylene (DDE) dictates that they associate with membranes, lipids and hydrophobic proteins in the biological environment. Their poor degradable nature causes DDT and DDE to persist for decades in the environment and in individuals who are or were in contact with the pesticide. In many countrie

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23

Taylor, Dale. "The Use of Combinations of Chemosensitisers to Reverse Chloroquine Resistance in Mice infected with Malaria." Doctoral thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/14394.

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Although several dozen different compounds are able to transiently alter chloroquine resistance via chemosensitisation, the phenomenon has never evolved beyond laboratory practice as a result of in vivo difficulties. Chemosensitising compounds either need to be administered at doses which are toxic to the host in order to reverse resistance, or the drug is so highly bound to serum proteins that there is an insufficient circulating quantity available to restore sensitivity. Nine chemosensitisers were evaluated in vitro against several resistant isolates of the malaria parasite in order to devel

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24

Fortuin, Elton E. "Novel aminoquinoline-polycyclic hybrid molecules as potential antimalarial agents." University of the Western Cape, 2014. http://hdl.handle.net/11394/4463.

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Magister Pharmaceuticae - MPharm<br>Plasmodium falciparum malaria continues to be a worldwide health problem, especially in developing countries in Africa and is responsible for over a million fatalities per annum. Chloroquine (CQ) is low-cost, safe and was the mainstay aminoquinoline derived chemotherapeutic agent that has been used for many years against blood-stage malaria. However, today the control of malaria has been complicated by increased resistance of the malaria parasite to existing antimalarial agents such as CQ. The primary cause of resistance is mutation in a putative ATP-powered

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25

Jourdan, Guy. "Etude comparative du traitement du paludisme a plasmodium falciparum chloroquinoresistant par la mefloquine et l'halofantrine : suivi biologique sous traitement ; a propos de 114 observations." Toulouse 3, 1989. http://www.theses.fr/1989TOU31704.

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26

Ursing, Johan. "Plasmodium Falciparum response to chloroquine and artemisinin based combination therapy (Act) in Guinea Bissau." Stockholm : Karolinska institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-695-8/.

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27

Haupt, Hayley Claire. "Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents." Master's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/6974.

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Bibliography: leaves 108-113.<br>Compounds containing the quinoline and acridine moieties have been utilized extensively in the search for new antiprotozoal and multidrug resistance reversal agents. Hence, these moieties formed the basis for the synthesis of new compounds. New sulfonamides, ureas and amine analogues were synthesized and evaluated for inhibitory activity against trypanothione reductase (TryR), in vitro activity against the causative agents of trypanosomiasis, leishmaniasis as well as chloroquine-sensitive and resistant malaria. Some were also evaluated as potential tumour multi

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28

Yeh, Susan. "An investigation of privileged substructural motifs as templates for the discovery and design of chloroquine-resistance reversal agents." Doctoral thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/3305.

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29

Hafiz, Rehan A. "The role of cytochrome P450 and P-glycoprotein in the development of resistance by Plasmodium falciparum to chloroquine." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU068608.

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1. Drug resistant strains of <I>P. falciparum</I> are becoming increasingly prevalent in most malaria endemic areas of the world, complicating treatment and prophylaxis. The prevalence of <I>P. falciparum</I> was assessed in six villages in the Punjab, Pakistan. The study was carried out during the months of August-October, 1992. A total of 566 people was surveyed. Fifty blood samples from positive plasmodial cases were analysed. Overall <I>P. falciparum</I> comprised the highest proportion of cases (62.39%) followed by <I>P. vivax</I> (36.7%) and mixed infection (0.85%) and mixed infection (0

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30

Crouzet, Isabelle. "Le paludisme chloroquino-résistant : à propos de 46 observations recueillies à l'hôpital de Cayenne (Guyane française)." Montpellier 1, 1988. http://www.theses.fr/1988MON11224.

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31

FADAT, GILLES. "Efficacite in vivo et in vitro de l'amodiaquine dans le traitement de l'acces palustre simple a plasmodium falciparum au cameroun (zone de chimioresistance a la chloroquine)." Lyon 1, 1991. http://www.theses.fr/1990LYO1M220.

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32

Vezmar, Marko. "Pharmacological effects of quinoline-related compounds in human tumour cells overexpressing the multidrug resistance protein (MRP)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0003/MQ37175.pdf.

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33

Matsabisa, Motlalepula Gilbert. "The antimalarial activity of Dicoma anomala and the chloroquine resistance reversing effects of Sclerocarya birrea on Plasmodium falciparum in vitro." Doctoral thesis, University of Cape Town, 2001. http://hdl.handle.net/11427/3427.

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Includes bibliographical references.<br>Two plants, Dicoma anomala [Sond.]; a member of the Asteraceae and Sclerocarya birrea [(A. Rich) Hoechst. subspecies caffra (Sond.) Kokwaro], a member of the Anarcadiaceae families, are used widely in Africa for a variety of traditional treatments. In this thesis it has been shown that these plants possess in vitro pharmacological activities against the malaria parasite. The extracts of D. anomala are active in vitro against Plasmodium falciparum and those of S. birrea selectively enhance the in vitro accumulation of chloroquine in resistant strains of P

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34

Liebman, Katherine May. "New 4-Aminoquinoline Compounds to Reverse Drug Resistance in P. falciparum Malaria, and a Survey of Early European Antimalarial Treatments." PDXScholar, 2014. http://pdxscholar.library.pdx.edu/open_access_etds/2114.

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Intermittent fevers caused by Plasmodium parasites have been known for millennia, and have caused untold human suffering. Today, millions of people are afflicted by malaria each year, and hundreds of thousands die. Historically, the most successful synthetic antimalarial drug was chloroquine, as it was safe, inexpensive, and highly efficacious. However, plasmodial resistance to chloroquine now greatly limits its utility. Previously in our laboratories it has been shown that attachment of a "reversal agent moiety" to the side chain of chloroquine can result in the restoration of activity agains

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35

Monserie, Catherine. "Traitement de recours face au paludisme à "Plasmodium falciparum" chloroquino-résistant : place de la méfloquine et de l'halofantrine." Paris 5, 1991. http://www.theses.fr/1992PA05P037.

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36

Jankowska-Döllken, Monika [Verfasser], and Michael [Akademischer Betreuer] Lanzer. "Functional studies on the chloroquine resistance transporter (PfCRT) and the HECT E3 ubiquitin-protein ligase (PfUT) in Plasmodium falciparum / Monika Jankowska-Döllken ; Betreuer: Michael Lanzer." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1192579186/34.

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37

Lelièvre, Joël. "Approche du mode d'action et du mécanismes de résistance pour trois antipaludiques : la chloroquine, l'artémisinine et la trioxaquine." Toulouse 3, 2007. http://www.theses.fr/2007TOU30005.

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Le paludisme, dont le principal agent est Plasmodium falciparum constitue un sérieux problème de santé publique. Malgré la fréquence des souches résistantes dans toutes les zones d'endémie, la plupart des pays utilisent encore la chloroquine en 1ère intention. Une meilleure connaissance des mécanismes de résistance et du mode d'action des molécules actuellement utilisées ou en développement permettrait d'obtenir des thérapeutiques ciblées. Parmi les molécules phares, l'artémisinine constitue une priorité du fait de son efficacité. Nous avons étudié l'activité des trioxaquines, molécules duales

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38

Villalta, Montoya Tamara. "Variation at position 86 of the pfmdr1 gene in samples from an area with seasonal transmission in eastern Sudan." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-111838.

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Malaria is the most common parasitic disease of humans worldwide. A factor that aggravates the many attempts to control the epidemiologic malaria situation is the spreading of resistance against anti-malarial drugs. In this project the point mutation at position 86 of the Plasmodium. falciparum multidrug resistance gene (pfmdr1), which is thought to contribute to Chloroquine resistance, was analysed in 188 samples from a low transmission area in eastern Sudan, where malaria endemicity is seasonal. The patient group studied had asymptomatic and sub patent parasitemia that persisted during the t

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39

Mangou, François. "Résistance de Plasmodium Falciparum et de Plasmodium Berghei à quatre antimalariques à noyau quinoléine : intervention des mécanismes de détoxication par les cytochromes P450 et le glutathion et rôle du gène Pbmdr." Bordeaux 2, 1999. http://www.theses.fr/1999BOR28663.

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40

Lindt, Meinrad. "Expression of the P-glycoprotein Homologue1 on food vacuoles isolated from Chloroquine-sensitive and resistant Plasmodium falciparum strains." Master's thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/26932.

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Worldwide occurrence of chloroquine resistance is an expanding problem in prophylaxis and treatment of malaria. Similarities between the drug resistance phenotype in certain cancers and in malaria suggest that homologue multidrug resistance proteins might be involved in the mechanism of resistance. In this thesis, the expression of a putative multidrug resistance protein of the malaria parasite Plasmodium falciparum, the P-glycoprotein homologue1 (Pgh1), was quantified on food vacuoles, the site of action of chloroquine. Chloroquine susceptibility was determined in 8 different P. falciparum st

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41

Ruddy, Samantha. "Preferential Estrogen Receptor β Ligands Inhibit Proliferation and Reduce Bcl-2 Expression in Fulvestrant-resistant Breast Cancer Cells". Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23669.

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Endocrine resistance is a significant clinical problem in the treatment of estrogen (E2) receptor positive breast cancers. There are two ER subtypes, ERα and ERβ, which promote and inhibit breast cancer cell proliferation respectively. While ER positive breast cancers typically express a high ratio of ERα to ERβ, the acquisition of antiestrogen resistance in vitro and in vivo is associated with increased relative expression of the ERβ. On some gene enhancers ERβ has been shown to function in opposition to the ERα in the presence of E2. Here we demonstrate that exposure to two different ERβ ag

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42

Lee, Andrew Hojin. "Investigating mutability and the plasmodium falciparum chloroquine resistance transporter in drug resistant malaria parasites." Thesis, 2016. https://doi.org/10.7916/D8X34XGD.

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Malaria persists today as a significant burden for a large part of the world. However, over the past few decades, a concerted effort by governments, non-governmental organizations, researchers, and community health workers worldwide has yielded progress in reducing the deadly impact of this disease. Today, some of these gains are threatened by the rise of antimalarial drug resistance, a recurring problem that has impeded global malaria reduction efforts before. Research on Plasmodium falciprum resistance to the numerous antimalarial compounds used today and in the past has made significant pro

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43

Shafik, Sarah. "Exploring the substrate specificity of the Plasmodium falciparum 'chloroquine resistance transporter'." Phd thesis, 2021. http://hdl.handle.net/1885/219247.

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The Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key contributor to multidrug resistance and is also essential for the survival of the malaria parasite, yet its natural function remains unresolved. The native substrates of PfCRT were investigated in both the Xenopus oocyte expression system and isogenic parasite lines expressing different pfcrt isoforms, using complementary physiological, biochemical, and metabolomic approaches. Host-derived peptides of 4-11 amino acid residues, varying in both charge and composition, were identified as the substrates of PfCRT in vit

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Kim, Jonathan Young. "Structural Investigation of Plasmodium falciparum Chloroquine Resistance Transporter in the Context of Anti-Malarial Drug Resistance." Thesis, 2019. https://doi.org/10.7916/d8-c5s0-ff42.

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Malaria is a mosquito borne infectious disease caused by a unicellular Apicomplexan parasite of the Plasmodia genus. The emergence and subsequent spread of drug resistance in the highly virulent Plasmodium falciparum parasite has been a major setback in eradicating malaria, which affects an estimated 216 million individuals and causes 445,000 deaths annually worldwide. Chloroquine (CQ) was once used as the first-line antimalarial drug treatment, until CQ-resistant parasites emerged in endemic regions including Africa, Southeast Asia, and South America. More recently, parasites have developed r

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45

Prozesky, Erwin Antoni. "Antiplasmodial- and chloroquine resistance reversal properties of a new diterpene from Croton steenkampianus." Thesis, 2005. http://hdl.handle.net/2263/27220.

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Malaria remains the most serious and deadly parasitic disease, affecting millions of people mostly in the poorest countries in the world. With no vaccine likely in the foreseeable future, drugs remain the best means of controlling the disease. Plants have provided most of the antimalarial drugs so far and it is likely that more antimalarial drugs will be discovered in this way. A previous study on South African plants yielded very good results on the extract level. In this study Croton steenkampianus leaf extract was selected for isolation of active principles. Bio-guided fractionation of the

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46

"In vivo tests of resistance to chloroquine by malaria parasites using adjunctive primaquine therapy and prophylaxis." Tulane University, 1994.

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Resistance to the blood schizonticidal drug chloroquine by malaria parasites causes severe problems where malaria is endemic. A better means of testing for resistance to chloroquine by malaria parasites may improve the efficacy of public health strategies for controlling morbidity and mortality caused by this disease. Resistance to chloroquine by Plasmodium vivax may be an important emerging problem, but there is no established procedure for detecting resistant strains. One possible approach is a primaquine adjunct to a standard in vivo test of resistance. Primaquine is a tissue schizonticidal

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Gabryszewski, Stanislaw J. "Dissecting the molecular basis of PfCRT-mediated antimalarial drug resistance." Thesis, 2016. https://doi.org/10.7916/D8V40VB0.

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The protozoan parasite Plasmodium falciparum is responsible for the deadliest form of malaria, which causes 584,000 fatalities annually and whose complications include coma, anemia, respiratory distress, and renal failure. Although malaria eradication efforts were hindered by the rise of chloroquine (CQ) resistance (CQR), CQ continues to be clinically deployed in resistance-free regions. CQR is primarily mediated by mutations in the P. falciparum chloroquine resistance transporter (pfcrt) gene, which also modulates parasite susceptibility to first-line artemisinin-based combination therapies (

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48

Summers, Robert Leon. "The malaria parasite’s chloroquine resistance transporter: An exploration of its interactions with drugs and of its evolution as a drug transporter." Phd thesis, 2016. http://hdl.handle.net/1885/118190.

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The malaria parasite’s chloroquine resistance transporter: An exploration of its interactions with drugs and of its evolution as a drug transporter Abstract: Initially identified as the primary determinant of chloroquine resistance in the malaria parasite Plasmodium falciparum, mutations in the ‘chloroquine resistance transporter’ (PfCRT) can influence the parasite’s susceptibility to diverse molecules. The ability of PfCRT to affect the activity of so many compounds is likely to be a product of its location at the membrane of the parasite’s d

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49

Vathsala, P. G. "Identification Of Chloroquine Resistant Haplotypes Of Plasmodium Falciparum In India And Development Of New Antimalarial Combinations." Thesis, 2006. https://etd.iisc.ac.in/handle/2005/368.

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Malaria afflicts 300-500 million people in the world and the mortality ranges from 1-2 million, children in Africa being the most susceptible. With a vaccine not being available against malaria and the front line drugs such as chloroquine and antifolates registering widespread parasite resistance, the challenge of malaria treatment is a formidable task. While, research to discover new drugs has become essential, it has also become necessary to identify therapeutic strategies in the short-term. One approach is to examine whether known drugs used for other applications can be used to trea

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Vathsala, P. G. "Identification Of Chloroquine Resistant Haplotypes Of Plasmodium Falciparum In India And Development Of New Antimalarial Combinations." Thesis, 2006. http://hdl.handle.net/2005/368.

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Malaria afflicts 300-500 million people in the world and the mortality ranges from 1-2 million, children in Africa being the most susceptible. With a vaccine not being available against malaria and the front line drugs such as chloroquine and antifolates registering widespread parasite resistance, the challenge of malaria treatment is a formidable task. While, research to discover new drugs has become essential, it has also become necessary to identify therapeutic strategies in the short-term. One approach is to examine whether known drugs used for other applications can be used to treat ma

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