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Dissertations / Theses on the topic 'CHM1'

Author: Grafiati
Published: 5 June 2025
Last updated: 2 August 2025

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1

Blaeschke, Franziska [Verfasser], Stefan [Akademischer Betreuer] [Gutachter] Burdach, and Uta A. D. [Gutachter] Behrends. "Generation of Ewing's sarcoma antigens CHM1- and EZH2-selective and HLA-A*0201-restricted T-cell receptor transgenic T cells / Franziska Blaeschke. Betreuer: Stefan Burdach. Gutachter: Stefan Burdach ; Uta A. D. Behrends." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1103658344/34.

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2

Dordor, Aurélien. "Etude du mécanisme de polymérisation des protéines du complexe ESCRT-III." Thesis, Grenoble, 2012. http://www.theses.fr/2012GRENV047/document.

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La machinerie ESCRT (Endosomal Sorting Complexes Required for Transport) est impliquée dans plusieurs processus cellulaires fondamentaux faisant intervenir le remodelage de structures membranaires comme la séparation des cellules filles lors de la division cellulaire ou le tri des protéines cargo vers le lysosome. Cette machinerie est détournée par de nombreux virus enveloppés comme le VIH pour assurer le bourgeonnement des virions.Le complexe ESCRT-III (constitué des protéines CHMP) est responsable de l'activité de fission membranaire de la machinerie en formant des structures polymériques qu
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3

Högger, Patrik Jules. "Dissemination of the cryphonectria hypovirus CHV1 /." [S.l.] : [s.n.], 1999. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13276.

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4

Schadel, Vanessa. "Identifikation neuer Komponenten der Chk1 vermittelten Signaltransduktion." [S.l. : s.n.], 2009. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-88315.

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5

Martinho, Rui Goncalo V. R. C. "Analysis of Rad3 and Chk1 checkpoint protein kinases." Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297946.

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6

Conchon, Elizabeth. "Synthèse de nouveaux carbazoles inhibiteurs de la Chk1." Clermont-Ferrand 2, 2006. https://theses.hal.science/tel-00717338/document.

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La granulatimide et l'isogranulatimide, molécules naturelles isolées d'une ascidie Didemmum granulatum sont connues pour être des inhibiteurs de la Chk1, enzyme régulatrice du point de contrôle en G2 du cycle cellulaire. La première partie de ce travail est consacrée à la présentation du point de contrôle en G2 du cycle cellulaire et plus particulièrement à la checkpoint 1 kinase Chk1. Dans une seconde partie, la synthèse de nouveaux carbazoles analogues de la granulatimide et l'isogranulatimide sera décrite. Parmi ces analogues l'hétérocycle imidique sera tout d'abord remplacé par un lactame,
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7

Platel, Marie. "Régulation du programme spatio-temporel de la réplication de l'ADN lors du développement précoce du Xénope." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS043.

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Chez les eucaryotes supérieurs, la réplication de l'ADN est initiée à partir de plusieurs milliers d'origines. Mais la régulation spatio-temporelle de leur activation reste mal caractérisée. Une voie de contrôle (checkpoint) de la phase S est activée lorsque les fourches de réplication sont bloquées, inhibant ainsi l'activation d'origines tardives. L'objectif de ma thèse consistait à étudier deux facteurs essentiels dans le programme spatio-temporel de la réplication, dans le système du xénope : la protéine « checkpoint » Chk1, qui est un facteur inhibiteur de l'activation des origines, et les
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8

Lang, Doris. "L1 and CHL1 : two members of the L1 family /." Zürich, 2000. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13402.

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9

Bernreuther, Christian. "Funktionelle Analysen der humanen neuralen Zellerkennungsmoleküle L1 und CHL1." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=969073542.

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10

Zhu, Cailei, and 祝彩磊. "Identification and characterization of CHL1 in esophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B46329559.

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11

Tho, Lye Mun. "Investigating the role of Chk1 in mouse skin homeostasis and tumourigenesis." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2504/.

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Chk1 is a key regulator of DNA damage response and genome stability in eukaryotes. To better understand how checkpoint proficiency affects cancer development particularly tumours induced by chemical carcinogens in murine skin, I investigated the effect of conditional genetic ablation of chk1. I found that complete deletion of chk1 immediately prior to carcinogen exposure strongly suppressed papilloma formation, and the few, small lesions that did form always retained Chk1 expression. Remarkably, chk1 deletion was accompanied by spontaneous cell proliferation followed by DNA damage and cell dea
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12

Guervilly, Jean-Hugues. "Activation et rôle de la voie Fanconi : interactions fonctionnelles avec CHK1." Paris 11, 2009. http://www.theses.fr/2009PA112181.

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L’anémie de Fanconi (AF) est un syndrome génétique humain rare associant anémie aplasique et prédisposition élevée aux cancers. Cette pathologie résulte de mutations dans l’un des gènes définissant la voie FANC/BRCA. Huit protéines FANC forment un complexe catalysant la réaction de mono-ubiquitinylation de FANCD2 et FANCI. La perte de cette voie résulte en une hypersensibilité aux agents pontant l’ADN tels la mitomycine C (MMC) et des défauts du cycle cellulaire. Nous avons montré que de nombreuses protéines intervenant lors de la réponse aux dommages de l’ADN régulent l’activation de la voie
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13

Clement, Jason Anderson. "Studies of Bioactive Natural Products and Mechanism-Based Bioassays." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/29879.

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An extract of the sponge <i>Rhabdastrella globostellifera</i> was active in an assay measuring stabilization of the binding of DNA with DNA polymerase &beta;. From this extract, four isomalabaricane triterpenoids were isolated and characterized, three of which were active in the binding assay. All compounds were active in the A2780 ovarian cancer cell line assay.&#13; Bioassay-guided fractionation of an extract of a sponge of species <i>Dysidea</i> using the A2780 bioassay yielded the known scalarane sesterterpenoid heteronemin in good yield. Four derivatives of heteronemin were prepared s
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14

Khan, Sara. "Adiposity and Pulmonary Function: Analysis of the Canadian Health Measures Survey (CHMS)." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23892.

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Adiposity has been linked to impaired respiratory function in adults but whether the distribution of adipose tissue has a differential effect on pulmonary function is still uncertain. Moreover, in children, the relationship between adiposity and lung dysfunction is not clearly understood. A two-stage multivariate analysis was conducted using data from 5604 Canadians aged 6 to 79 years who participated in the Canadian Health Measures Survey (CHMS). The associations of various anthropometric and skinfold measures with lung function were examined separately in adults and children. After adjustmen
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15

Oehler, Verena. "Role of Chk1 and Chk2 in mitotic checkpoint control in vertebrate cells." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/148/.

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Two conserved protein kinases, Chk1 and Chk2, are activated in response to genotoxic stress and mediate multiple cell cycle checkpoint mechanisms that ensure genomic integrity. The establishment of mitotic checkpoint delay in response to DNA damage or incompletely replicated DNA is conventionally thought to be accomplished through inhibition of the cyclin-dependent kinase, Cdc2. Both Chk1 and Chk2 have the potential to operate in this pathway. Therefore, the initial aim of this study was to investigate the relative requirement of Chk1 and Chk2 for mitotic delay mechanisms triggered by DNA dama
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16

Toh, Yew Kwang. "Docking-dependent regulation of checkpoint kinase chk1 by the growth regulator p21WAF1." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4215.

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Checkpoint kinase 1 (Chk1) is a key player in the DNA damage response signalling pathway and the mode of Chk1 activation whereby it undergoes ATRdependent phosphorylation at Ser317 and Ser345 is well characterised. It has been suggested that phosphorylation at the ATR sites relieves the auto-inhibitory action conferred by the C-terminal negative regulatory domain on the catalytic core of Chk1. In this study, we show that Chk1 activity can also be stimulated by docking to an N-terminal region of the growth regulator p21waf1 and this docking domain is necessary for efficient Chk1-dependent phosp
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17

Kim, Catherine S. "Investigating the Influence of CHD1 on Newly Deposited Histones in Drosophila Melanogaster." Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/scripps_theses/584.

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Chromatin remodelers such as CHD1 (chromodomain, helicase/ATPase, DNA-binding domain) regulates histone dynamics and allows for higher order of chromatin compaction.CHD1 has been found to be important in fertility, wing development, and it colocalizes with elongating RNA polymerase II in Drosophila melanogaster. CHD1 is also important in embryonic stem cell pluripotency in mice and chd1 is the second most deleted gene in prostate cancer in humans. Furthermore, CHD1 suppresses the level of H3 dimethylated on lysine 9 (H3K9me2) and heterochromatin protein 1a (HP1a) to antagonize repressive chrom
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18

Cartel, Maëlle. "Fonctions et régulations de la kinase CHK1 dans l'hématopoïèse normale et leucémique." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30150.

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La protéine Checkpoint kinase 1 (CHK1) est un acteur clé du cycle cellulaire qui agit comme un agent double, à la fois dans un contexte cellulaire normal mais également en condition de stress tel que l'apparition de dommages à l'ADN. Ma thèse a consisté à évaluer les fonctions et la régulation de cette protéine dans ces deux contextes, en m'intéressant à l'hématopoïèse normale et leucémique. Plusieurs études mettent déjà en avant un rôle de CHK1 dans l'hématopoïèse normale, mais une meilleure compréhension de l'importance de CHK1 dans la différenciation, notamment dans la voie mégacaryocytaire
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19

Stones, Rachel Suzanne. "Integration and racemisation for the CHMO catalysed synthesis of optically pure lactones." Thesis, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394466.

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20

Huber, Bryan. "Evaluation of CHK1 and WEE1 as Candidate Sensitizers to Cisplatin and Paclitaxel." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/281179.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Ovarian cancer is the foremost cause of death from gynecologic malignancies in the developed world. The American Cancer Society estimated 22,280 new cases in 2012 and 15,500 deaths. The majority of patients with advanced ovarian cancer relapse from primary treatment and develop drug-resistant disease. The mechanisms underlying drug-resistance are poorly understood. Inhibition of CHK1, a cell cycle G2/M checkpoint kinase has previously
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21

Egger, Tom. "Mutations de la voie ATR-CHK1, réponse au stress réplicatif et cancer." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT031.

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Le cancer colorectal est responsable de plus de 17500 décès par an et se situe à la 3ème place des cancers les plus fréquents en France. En altérant le processus de réplication de l’ADN des cellules cancéreuses, certaines des molécules utilisées en chimiothérapie induisent du stress réplicatif. Au niveau cellulaire, ce stress est géré par la voie ATR-CHK1. Quand elle est activée par des régions d’ADN simple brin protégées par RPA au niveau de fourches de réplication ralenties/bloquées, ATR déclenche l’activation du checkpoint intra-S via la phosphorylation de son effecteur CHK1. Ce checkpoint
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22

Asif, Muhammad. "Customization of Docbook to Generate PDF, HTM & CHM." Thesis, Linköping University, Department of Computer and Information Science, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-52484.

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<p>Software documentation is an important aspect of software projects. Software documentation plays a key role in software</p><p>development if it is up-to-date and complete. Software documentation should have the synchronization with the software</p><p>development. One of the problems is duplication; same information is written in different documents and stored in different</p><p>places with different formats making things complex to manage. By using traditional documentation tools, it’s hard to maintain</p><p>documentation for complex systems and it is time consuming.</p><p>To overcome these
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23

Rolf, Bettina. "Functional analysis of the cell adhesion molecules L1, CHL1 and NCAM in vivo." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965755711.

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24

Conchon, Elisabeth. "Synthèse de nouveaux carbazoles inhibiteurs de la Chk1. Etude de leurs propriétés biologiques." Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2006. http://tel.archives-ouvertes.fr/tel-00717338.

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La granulatimide et l'isogranulatimide, molécules naturelles isolées d'une ascidie Didemmum granulatum sont connues pour être des inhibiteurs de la Chk1, enzyme régulatrice du point de contrôle en G2 du cycle cellulaire. La première partie de ce travail est consacrée à la présentation du point de contrôle en G2 du cycle cellulaire et plus particulièrement à la checkpoint 1 kinase Chk1. Dans une seconde partie, la synthèse de nouveaux carbazoles analogues de la granulatimide et l'isogranulatimide sera décrite. Parmi ces analogues l'hétérocycle imidique sera tout d'abord remplacé par un lactame,
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25

Thompson, Ruth Helen. "Inhibition of Chk1 abrogates differential cell cycle responses to cisplatin whilst enhancing cytotoxicity." Thesis, University of Sheffield, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527234.

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26

施國雄 and Johnny Sze. "Heterologous expression and localization of cryptic haloacid dehalogenase Chd1 of Burkholderia cepacia MBA4." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3122670X.

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27

Farnung, Lucas [Verfasser], and Patrick [Akademischer Betreuer] Cramer. "Nucleosome-Chd1 structure and implications for chromatin remodelling / Lucas Farnung ; Betreuer: Patrick Cramer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1148276181/34.

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28

Saavedra, Bocanegra Stephy. "Producción de L-asparaginasa intracelular en Bacillus sp. CH11 halotolerante en cultivo discontinuo." Master's thesis, Universidad Nacional Mayor de San Marcos, 2021. https://hdl.handle.net/20.500.12672/17518.

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L-asparaginasa hidroliza L-asparagina generando ácido aspártico y amonio; utilizada en la industria farmacéutica, alimentaria, y biomédica, producida por diversos microorganismos. Por esta razón, se investigó la producción de L-asparaginasa intracelular en Bacillus sp. CH11 halotolerante en cultivo discontinuo. Para ello, se realizó un screening en 13 cepas del género Bacillus aisladas de las salinas de Maras (Cusco), Chilca (Lima) y Pilluana (San Martín) en medios de producción de L-asparaginasa conteniendo colorantes indicadores de pH; 10 cepas fueron productoras de esta enzima. Despué
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Sze, Johnny. "Heterologous expression and localization of cryptic haloacid dehalogenase Chd1 of Burkholderia cepacia MBA4 /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23735892.

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30

Wang, Wei-Ting. "Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/7080/.

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This study focuses on the apparently distinct roles of various checkpoint associated kinases including ATM, ATR, and CHK1 in bladder cancer compared with normal human urothelial (NHU) cells. The primary signalling cascade that responds to replication stress in bladder cancer cells (ATR-CHK1) is deficient in normal urothelial cells after treatment with a replication inhibitor and these cells do not depend upon CHK1 for protection from apoptosis during replication stress. This is very different from the situation in bladder cancer cells, where ATR-CHK1 plays a prominent role. Instead ATM signall
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Yuan, Ling Li. "Les kinases Pim phosphorylent Chk1 et régulent ses fonctions dans les leucémies aiguës myéloïdes." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2197/.

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La kinase Chk1 est un régulateur central des points de contrôles du cycle cellulaire qui sont importants pour maintenir la stabilité génétique. La phosphorylation par Akt sur la Ser280 entraîne la rétention cytoplasmique et l'inactivation de la kinase Chk1, ce qui conduit à l'instabilité génétique des cellules PTEN-/-. Dans les cellules de leucémies aiguës myéloïdes portant la mutation Flt3-ITD, nous avons observé des taux élevés de phosphorylation de Chk1 sur la Ser280. De plus, cette phosphorylation est dépendante de l'activité de Flt3-ITD. Des inhibiteurs pharmacologiques et d'interférence
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32

Wyatt, Brent. "Chromodomain Helicase DNA Binding Protein 1 (Chd1) is required for orofacial development in Xenopus." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5365.

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Abnormalities affecting orofacial development are some of the most common, expensive, and devastating birth defects. Children born with such defects may experience difficulties with eating, breathing, and speech and in addition, these defects often require multiple surgeries to correct them. Therefore, it is critical to understand how the orofacial region develops in order to better treat and prevent these types of birth defects. Xenopus laevis has emerged as a strong model in which to examine orofacial development and was utilized here to investigate the cellular and molecular mechanisms unde
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Yin, Ling. "Activation of DNA Replication Initiation Checkpoint in Fission Yeast." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/194.

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In the fission yeast, Schizosacchromyces pombe, blocks to DNA replication elongation trigger the intra-S phase checkpoint that leads to the activation of the Cds1 kinase. Cds1 is required to both stabilize stalled replication forks and to prevent premature entry into mitosis. Interestingly, although Cds1 is essential to maintain the viability of mutants defective in DNA replication elongation, my study shows that mutants defective in DNA replication initiation require the Chk1 kinase, rather than Cds1. This suggests that failed initiation events can lead to activation of the DNA damage checkpo
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Thompson, Mark David, and Mark David Thompson. "Channelrhodopsin-1: Cellular Localization and Role in Eyespot Assembly and Placement in Chlamydomonas reinhardtii." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/620817.

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The eyespot of the single-celled alga Chlamydomonas aids the cell in detecting the direction of light in the environment. The complex assembly and asymmetric placement of the eyespot provides a model to ask questions about assembly and asymmetric placement of organelles. Understanding the mechanisms that underlie assembly and asymmetric placement of the eyespot can be applied more broadly to their functions in other eukaryotic organisms. This study sought to understand the role of a key protein in those processes, Channelrhodopsin-1 (ChR1). ChR1 was found to localize along the entire length o
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Carter, Ayesha DonNell. "Loss of Chk1 Function and Exogenous Expression of Cyclin A1/Cdk2 Results in Apoptosis after the MBT in Early Xenopus laevis Embryos." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/27644.

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Early Xenopus laevis embryonic cell cycles exemplify rapid, non-pathological cell cycles without checkpoint pathways to arrest cell cycles in response to DNA assaults. There is no transcription or apoptosis during these cell cycles, and they continue unperturbed until the 12th cell cycle, marking a period called the midblastula transition (MBT). At the MBT, the embryo undergoes a period of developmental remodeling: gap phases are acquired, zygotic transcription is initiated, and the maternal mRNAs are degraded. After the MBT, checkpoint pathways can be activated in response to unreplicated
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Adjerid, Nassiba. "The Dynamics of the Unreplicated DNA Checkpoint in Xenopus laevis Embryos and Extracts." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/26681.

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When unreplicated or damaged DNA is present, cell cycle checkpoint pathways cause cell cycle arrest by inhibiting cyclin-dependent kinases (Cdks). In Xenopus laevis, early embryonic development consists of twelve rapid cleavage cycles between DNA replication (S) and mitosis (M) without checkpoints or gap phases. However, checkpoints are engaged in Xenopus once the embryo reaches the midblastula transition (MBT). At this point, the embryo initiates transcription, acquires gap phases between S and M phases, and establishes a functional apoptotic program. During the cell cycle, there are two mai
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Wang, Yulin. "Discovering novel immunoregulatory molecules that can be manipulated for clinical advantage." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/420595.

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The successful control of malaria parasites by an infected host requires complex and balanced interactions between pro-inflammatory and regulatory immune responses. An excessive, dysregulated pro-inflammatory response results in tissue damage and the subsequent development of severe pathologies, with the routinely fatal cerebral malaria among them. Conversely, uncontrolled immunoregulatory responses promoted by Plasmodium species serve to inhibit protective host immunity, contributing to the delay, or even failure, of parasite clearance. The most advanced anti-malarial vaccine candidate RTS,S
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Akinsete, Juliana. "CHMP1 is implicated in the development of pancreatic tumor via the retinoic acid signaling pathway." Huntington, WV : [Marshall University Libraries], 2006. http://www.marshall.edu/etd/descript.asp?ref=694.

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Wright, Amanda Gates Maness Patricia. "Close Homolog of L1 CHL1 mediates guidance of thalamocortical axons through extracellular and intracellular interactions." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1402.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Apr. 25, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biochemistry and Biophysics." Discipline: Biochemistry and Biophysics; Department/School: Medicine.
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Bui, Phuongngan Thi. "Investigating the Influence of CHD1 on Gene Expression in Drosophila Melanogaster Using Position Effect Variegation." Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/scripps_theses/537.

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Position Effect Variegation (PEV) is the mosaic expression of a gene that has been moved out of its optimal environment and into a different area on the chromosome. Changing a gene’s environment may have profound effects on its eligibility for proper expression, which is a complicated process regulated by many factors. The PEV phenomenon is used as an assay to study gene expression as regulated by chromatin structure. In this study, the Drosophila melanogaster white gene was used as a reporter to study the various effects of CHD1, a chromatin regulating factor, on PEV gene expression. Inspired
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Fokas, Emmanouil. "Targeting the PI3K/mTOR and ATK/Chk1 pathways to improve radiation efficacy for cancer therapy." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572788.

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The purpose of the present thesis was to better understand the effect of targeting key biological mechanisms in order to improve radiotherapy response. Two important and distinct pathways were targeted using novel agents: (1) the phosphoinoside-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway; (2) the ataxia telangiectasia-mutated-Rad3-related (ATR)/Chkl pathway. The role of the PI3K1mTOR signalling pathway in tumour radiosensitivity and tumour microerivlronment (TME) was examined using three, recently-developed signalling inhibitors obtained from Novartis Pharma: NVP-BEZ235 (d
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Liu, Jessica Chishow. "Biochemical Characterization of the Domain Architecture of Chromatin Assembly Motor Proteins Human CHD1 and CHD2." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226060.

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The sites where the basic unit of chromatin, the nucleosome, is assembled greatly affects the dynamic compaction/decompaction of eukaryotic genetic material and how the DNA is accessed, read, and interpreted. The nucleosome, which consists of ~147 base pairs of DNA wrapped in a left-handed superhelix around an octameric core made up of histone proteins, is the targeted substrate for ATP-dependent protein machineries called chromatin remodelers. Remodelers are essential regulators of DNA accessibility and are often grouped into four families: SWI/SNF, INO80/SWR1, ISWI, and CHD. Though remodeler
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Svensson, Susanne. "In vitro and in vivo inhibition of Chk1 sensitize lung cancer stem cells to chemotherapy." Thesis, Universita' degli Studi di Catania, 2011. http://hdl.handle.net/10761/98.

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Development of resistance to radiation and chemotherapy turns the treatment of solid cancers into a therapeutic challenge. One of the most exciting breakthroughs being explored in cancer research today is the concept of cancer stem cells (CSCs). CSCs are a minority of cells within a tumor that are the source of tumor cell renewal and thereby determine the behavior of tumors, including proliferation, spreading and response to therapy. CSCs are highly resistant to conventional treatment and are therefore emerging as the preferred target of drug therapies in order to obtain eradication of tumors.
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Domingues, Stefany Fontes. "Caracterização das interações protéicas envolvidas no tráfego celular do transportador de colina de alta afinidade - CHT1." Universidade Federal de Minas Gerais, 2006. http://hdl.handle.net/1843/SMOC-6W7NGY.

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The high affinity choline transporter (CHT1) is responsible for choline uptake, which is derived from acetylcholine degradation, in the synaptic cleft of cholinergic neurons. CHT1 activity is very important since cholinergic neurons have very low ability to synthesize acetylcholine de novo. Although CHT1 is mainly a plasma membrane transporter, it is found predominantly recycling between intracellular vesicles and the cell surface. Cellular trafficking seems to play an important role in the transporter activity. In the present experiments, we identified proteins that might interact with CHT1,
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45

Höglund, Andreas. "Regulation of DNA damage responses by the Myc oncogene : implications for future anti-cancer therapies." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-44284.

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Myc is a transcription factor frequently found deregulated in human cancer. Cells with deregulated expression of Myc carry a selective advantage against its neighbours due to the fact that Myc-mediated transcription governs crucial cellular events such as proliferation and growth. In addition, Myc has been implicated in several other aspects of tumour biology like cellular immortality, the formation of new blood vessels and the colonization of distant tissues through the process of metastasis. Therapy aimed at disrupting essential pathways regulated by Myc is important because of the many diff
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46

Colapinto, Cynthia. "Examining the Folate Status of Canadians: An Analysis of the Canadian Health Measures Survey to Assess and Guide Folate Policies." Thesis, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/26103.

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Canada fortifies certain products with folic acid and has periconceptional supplementation guidelines – policies designed to improve folate status and reduce the incidence of poor birth outcomes. Though optimal folate concentrations have been linked to health benefits, concerns have been raised regarding potential associations with adverse health outcomes. Direct biochemical assessment of the folate status of Canadians based on a nationally representative sample has not been done in more than 40 years. The overall purpose of this research was to investigate the folate status of the Canadian po
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Silva, Isilda Cristina Laranjeira da. "Empenhamento organizacional dos enfermeiros do Centro Hospitalar do MédioTejo." Master's thesis, FEUC, 2011. http://hdl.handle.net/10316/23242.

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Dissertação de mestrado em Gestão e Economia da Saúde, apresentada à Faculdade de Economia da Universidade de Coimbra, sob a orientação de Manuela Frederico.<br>Todas as organizações, nomeadamente as organizações de saúde estão em processo de mudança. Pretendem-se os melhores resultados com os mais baixos custos. Mudam-se politicas, estratégias, objectivos e regras. Mas muitas vezes os gestores esquecem o essencial: o capital humano da organização. Os gestores das organizações de saúde devem compreender que os seus colaboradores devem ser integrados num processo de mobilização para a excel
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Rittenour, William R. "The biological control potential of Cryphonectria parasitica strains containing an infectious cDNA copy of hypovirus CHV1-Euro7." Morgantown, W. Va. : [West Virginia University Libraries], 2005. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4200.

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Thesis (M.S.)--West Virginia University, 2005.<br>Title from document title page. Document formatted into pages; contains vii, 79 p. : ill. (some col.), col. map. Includes abstract. Includes bibliographical references (p. 68-75).
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Binti, Abd Kadir Nurul Huda. "Cytotoxicity of 2-propenyl and 3-butenyl glucosinolate hydrolysis products in cHo1 and MCL 5 cell lines." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/39393.

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Aubets, Gil Eva. "Gene Silencing of WEE1, CHK1 and Thymidylate Synthase using PPRHS. Non-Viral and Viral Delivery of PPRHs." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673927.

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This work is focused on the study of Polypurine Reverse Hoogsteen hairpins (PPRHs) as a gene silencing tool, and on the search of alternative methods for their delivery, including viral and non-viral vectors. PPRHs are single stranded non-modified DNA hairpins formed by two antiparallel polypurine mirror repeat strands linked by five thymidines and bound intramolecularly by Hoogsteen bonds. These hairpins can bind specifically to a pyrimidine target sequence in genomic DNA and induce the displacement of the purine strand, resulting in the inhibition of gene expression. During the last decade,
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