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Relevant bibliographies by topics / CHO HOST CELL PROTEINS

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Dissertations / Theses

Academic literature on the topic 'CHO HOST CELL PROTEINS'

Author: Grafiati

Published: 11 September 2023

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Dissertations / Theses on the topic "CHO HOST CELL PROTEINS"

1

Goey, Cher Hui. "Cascading effects in bioprocessing : the impact of cell culture environment on CHO cell behaviour and host cell protein species." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/52703.

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One of the reasons for the rejection of new drugs during clinical trials is the presence of host cell proteins (HCPs) in the drug formulation. HCPs are immunogenic impurities that can compromise patient safety. Moreover, proteolytic and binding HCPs compromise the integrity, and, hence, the stability and efficacy of a recombinant protein. Therefore, HCPs should be removed from the bioprocess train as soon as possible. Current downstream purification platforms are challenged by HCP-mAb co-elution. A Quality by Design strategy to overcome this problem is to reduce the number of HCPs in the downs

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2

Carr, Sharon. "Adenovirus and its interaction with host cell proteins /." St Andrews, 2007. http://hdl.handle.net/10023/219.

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3

Qashqari, Fadi Saleh I. "Regulation of host cell proteins by adenovirus oncoproteins." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/8020/.

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Adenovirus early region proteins, ElA, E1B-55K, E4orf3 and E4orf6 regulate host cell processes to facilitate viral replication. E4orf3 suppress host cell anti-viral activities through association with host cell proteins in E4orf3 nuclear-track structures, whilst E1B-55K, E4orf3 and E4orf6 are all recruited to viral replication centres during infection to promote viral DNA replication and inhibit host cell antiviral activities. Immunoprecipitation coupled to mass spectrometry identified Toplla as an Ad12 E4orf3-binding protein that localized with E4orf3 in adenovirus-infected cells. It was dete

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4

Bjertsjö, Rennermalm Anna. "Staphylococcal cell wall associated proteins : characteristics and host interactions /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-542-9/.

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5

Huang, Edwin P. C. Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line." Awarded by:University of New South Wales. School of Biotechnology and Biomolecular Sciences, 2006. http://handle.unsw.edu.au/1959.4/24940.

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A novel metal-inducible and amplifiable metallothionein (MT) expression system, pNK, was firstly optimised and characterised for the production of a reporter protein, human growth hormone (hGH) in a suspension CHO cell line grown in a serum-free media. The pNK-based hGH production was demonstrated in cadmium-free condition under various fermentation modes (batch, fed-batch and perfusion) and scales (flask to bench-top bioreactor). Improvement of specific productivity of recombinant protein from pNK was shown to be possible by addition of butyrate or substrate substitution of glutamine by gluta

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6

Mohamed, Ahmed Attia Ali. "Interaction of hepatitis C virus polymerase with host cell proteins." Thesis, Durham University, 2009. http://etheses.dur.ac.uk/2107/.

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Hepatitis C virus (HCV) interacts with host cell proteins to modify cellular pathways creating a favourable environment that facilitates its replication and persistence. The purpose of the work presented in this thesis was to identify cellular proteins that can interact with NS5B, the virus's RNA-dependent RNA polymerase, that may contribute to the virus's biology. A number of cellular proteins were found to interact with NS5B using the yeast two-hybrid system. These proteins were involved in cellular pathways such as interferon signalling, lipid transport and metabolism, protein trafficking,

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7

Goldman, Merlin Hesper. "The effect of process variables on the glycosylation of gamma-interferon produced in CHO cells." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244743.

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8

Patel, Amit. "Interaction of enteropathogenic 'Escherichia coli' (EPEC) tir with host cell proteins." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431869.

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9

Cowlishaw, Deborah Anne. "Identification of host proteins required for bacteriophage infection of Streptomyces sp." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367589.

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10

Rytkönen, Anne. "Molecular studies of Neisseria - host cell interactions /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-018-4/.

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