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Dissertations / Theses on the topic 'Cholera, microbiology'

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Published: 4 June 2021
Last updated: 28 July 2025

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1

Amediavor, Rita Laryea. "The Persisting Threats Of Cholera: A Cyclical Public Health Problem In Ghana." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1598992794308852.

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2

Saul-McBeth, Jessica. "Characterization of SipA, A Protein Important for Stress Responses in Vibrio cholerae." University of Toledo Health Science Campus / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=mco1544540466901883.

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3

Jahan, Nasrin. "Structural studies of Vibrio cholerae quorum sensing proteins." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2565.

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The spread of cholera is always associated with contaminated food or water and this is the reason this disease has been endemic in developing countries for centuries due to their lack of proper sanitation facilities and poor or no infrastructure for sewage systems. Cholera can spread quickly and sporadically after any natural disaster that destroys the sewage system or safe drinking water supply of both developed and undeveloped countries. In Southeast Asia in December 2004 and in Pakistan and Haiti 2010, cholera outbreaks followed the natural disasters; with most of the cholera victims being
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4

Harper, Marina. "Virulence determinants of Pasteurella multocida." Monash University, Dept. of Microbiology, 2003. http://arrow.monash.edu.au/hdl/1959.1/9341.

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5

Lo, Miranda. "Characterisation of in vivo expressed proteins of Pasteurella multocida." Monash University, Dept. of Microbiology, 2003. http://arrow.monash.edu.au/hdl/1959.1/9429.

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6

Villeneuve, Sylvain. "Caractérisation immunochimique des déterminants antigéniques du lipopolysaccharide de Vibrio cholerae O1 en vue de la préparation d'un vaccin anticholérique chimiquement défini." Paris 5, 1999. http://www.theses.fr/1999PA05N124.

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7

Resch, Craig. "Biochemistry and physiology of NhaP-type antiporters in Vibrio cholerae." Elsevier, 2010. http://hdl.handle.net/1993/31098.

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Antiporters that exchange alkali cations (Na+ or K+) for protons play an important role in the physiology of all known bacterial species. They are involved in regulating intracellular pH and maintaining cellular volume as well as the formation of a chemical Na+ gradient across the membrane, which is important to many bacteria as an energy source for processes such as accumulation of substrates, ATP synthesis, and flagellar rotation. Another important role of cation/proton antiporters is homeostasis of intracellular cation content. The situation of a thermodynamic equilibrium of Na+ or K+ on t
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8

SCIARAFFIA, ESTER. "Effects of cholera toxin on cells of immune system." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/1070.

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In questa tesi sono stati analizzati gli effetti della Tossina Colerica (CT) sulle cellule del sistema immunitario. In particolare, sono stati studiati i meccanismi di inibizione della proliferazione dei linfociti T CD4+ e CD8+ umani da parte della CT. E’ stato osservato che la CT è in grado di prevenire l’attivazione dei linfociti T nelle fasi precoci e tale inibizione coinvolge la modulazione dell’espressione delle molecole CTLA-4 e CD28. E’ stato osservato che la CT up-regola l’espressione delle molecole inibitorie CTLA-4 e down-modula le molecole costimolatorie CD28 sui linfociti T CD4+ e
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9

Hillary, Janet Barbara. "Investigation into the molecular mechanism of toxin secretion from Vibrio cholerae." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263928.

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10

Schroeder, Irmagard Cherè. "Molecular and functional characterization of the melanin biosynthetic genes from Vibrio cholerae 569B." Doctoral thesis, University of Cape Town, 1998. http://hdl.handle.net/11427/16110.

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Bibliography: p. 155-177.<br>V. cholerae 569B is a bacterium infamous for its role as the causative agent of the diarrhoeal disease cholera. Although the bacterium occurs naturally in brackish waters and estuaries, cholera outbreaks are closely linked to specific environmental conditions. For example, most outbreaks occur during the summer months when the bacterium experiences an increase in water temperature, play a role in activating virulence in V. cholerae 569B, the exact mechanism remains to be elucidated. Previously it was observed that when V. cholerae is exposed to elevated temperature
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11

Pérez-Soto, Nicolás. "Taming Vibrio cholerae with cationic polymers : engineering bacterial physiology by interfering with communication and virulence." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8857/.

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The Gram-negative Vibrio cholerae is native to aquatic environments and an important human pathogen causing cholera disease. The induction of virulence in this bacterium is subjected to a wide variety of stimuli including environmental cues and quorum sensing. In this study, non-bactericidal cationic polymers were designed to capture Vibrio cholerae into clusters resulting in physiological changes. Poly(N-(3-aminopropyl) methacrylamide) (P1), poly(N-[3-dimethylamino)propyl] methacrylamide) (P2) or poly(acryloyl hydrazide) imidazole (P3) were synthesised via free radical polymerisation displayi
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12

Gerding, Matthew. "Molecular Dissection of the Essential Features of the Origin of Replication of the Second Vibrio Cholerae Chromosome." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467189.

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Vibrionaceae family members are interesting models for studying DNA replication initiation as they contain two circular chromosomes. Chromosome II (chrII) replication is governed by two evolutionarily unique, yet highly conserved elements: the origin DNA sequence, oriCII, and the initiator protein, RctB. The minimum functional region of oriCII, oriCII-min, contains multiple elements that are bound by RctB in vitro, but little is known about the specific requirements for individual elements during oriCII initiation. We utilized undirected and site-specific mutagenesis to investigate the func
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13

Iredell, J. R. "Molecular export and pilin assembly : TCP biogenesis in Vibrio cholerae /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phi648.pdf.

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14

Flores, Aguilar Lidia Escolástica. "Caracterización fenotípica y genotípica de estirpes de Salmonella choleraesuis aisladas de ambientes marinos." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2003. https://hdl.handle.net/20.500.12672/803.

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Bacterias patógenas como Salmonella, habitantes naturales del tracto intestinal de diversos animales incluido el hombre, están comúnmente presentes en efluentes de desagües principalmente domésticos que desembocan al mar en forma directa o indirecta a través de ríos y acequias, llegando a constituir parte de la flora contaminante del litoral limeño y de los alimentos provenientes del mismo. La presencia de Salmonella está determinada por las condiciones biológicas y fisicoquímicas del ambiente acuático, que permiten su supervivencia, desarrollando mecanismos de adaptación como entrar a un esta
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15

Zhao, Xiaonan. "Non-coding small RNAs regulate multiple mRNA targets to control the Vibrio cholerae quorum sensing response." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/47677.

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The waterborne bacterial pathogen Vibrio cholerae uses a process of cell-to-cell communication called quorum sensing (QS) to coordinate transcription of four sRNAs (Qrr1-4; quorum regulatory RNAs) in response to changes in extracellular QS signals that accumulate with cell density. The Qrr sRNAs are predicted to negatively control translation of several mRNAs, including hapR, which encodes the master QS transcription factor that controls genes for virulence factors, biofilm formation, protease production, and DNA uptake. The Qrr sRNAs are also predicted to positively control vca0939, which en
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16

STAUDER, MONICA. "Adesine di Vibrio Cholerae: ruolo ecologico e nuove prospettive per lo sviluppo di vaccini." Doctoral thesis, Università Politecnica delle Marche, 2011. http://hdl.handle.net/11566/243019.

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Il colera è una patologia a trasmissione oro-fecale causata da Vibrio cholerae, un microorganismo indigeno delle acque costiere dove può trovarsi sia in forma planctonica che in associazione a piante e animali acquatici. La sopravvivenza e la diffusione di V. cholerae nelle acque e l’acquisizione di determinanti di virulenza sono fortemente influenzate da fattori quali temperatura, salinità, pH e, in particolare, dalla presenza di organismi dello zooplancton. Infatti, V. cholerae è in grado di aderire tenacemente all’esoscheletro chitinoso dei crostacei zooplanctonici e, soprattutto, dei copep
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17

Roussel, Jainaba. "The cAMP receptor protein controls Vibrio cholerae gene expression in response to host colonisation." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8250/.

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The bacterium Vibrio cholerae is the causative agent of the acute diarrhoeal disease cholera. V. cholerae is naturally found in aquatic environments but can switch lifestyles to cause disease in humans. The lifestyle switch requires modulation of genetic systems. Much of the regulation occurs at the level of gene expression and is controlled by transcription factors. In this work, I show that the global transcription regulator, cAMP receptor protein (CRP), plays an integral role in the regulatory network that controls lifestyle switching. I have identified two sites for CRP in the intergenic r
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18

Bradley, Evan. "Discovery and characterization of small non-coding RNAs in Vibrio cholerae that contribute to gene regulation during infection." Thesis, Sackler School of Graduate Biomedical Sciences (Tufts University), 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3624938.

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<p> Small non-coding RNAs (sRNAs) are being increasingly recognized as critical regulators of a wide variety of processes in bacteria. To investigate the contribution of unknown sRNAs to virulence gene regulation in <i>Vibrio cholerae,</i> we undertook a screen to identify previously uncharacterized sRNAs under the control of the major virulence gene activator in <i> V. cholerae,</i> ToxT. Using a combination of direct sRNA cloning and sequencing together with a genome-wide ToxT <i>in vitro</i> binding assay, we identified 18 putative ToxT-regulated sRNAs. Two of these ToxT regulated sRNAs wer
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19

DeAngelis, Cara Marie. "Characterization of the Vibrio cholerae Phage Shock Protein Response." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1556723496251854.

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20

Jones, Lim Stephen. "Mobile genetic elements associated with blaNDM-1 in Acinetobacter spp. and Vibrio cholerae." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/74109/.

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NDM-producing bacteria are associated with extensive antimicrobial resistance (AMR). This thesis reports on detailed molecular analysis, including whole genome sequencing, of Acinetobacter spp. and Vibrio cholerae isolates. A study of clinical Acinetobacter baumannii isolates from India, demonstrated spread of a single strain containing blaNDM-1 but with evidence of significant genetic plasticity between isolates. A novel plasmid, pNDM-32, was fully characterised in isolate CHI-32. This contained multiple AMR genes including blaNDM-1 and the aminoglycoside methyltransferase gene armA. A repAci
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21

Vaitkevicius, Karolis. "Effects of Vibrio cholerae protease and pigment production on environmental survival and host interaction." Doctoral thesis, Umeå universitet, Molekylärbiologi (Medicinska fakulteten), 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1474.

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Only two out of more than 200 V. cholerae serogroups, classified on the basis of LPS structure, are associated with epidemic or pandemic cholera. These toxigenic serogroups carry phage-derived pathogenicity islands coding for the main virulence factors for establishment of cholera disease – cholera toxin (CTX) and toxin-coregulated pilus (TCP). The latter also serves as a bacterial surface receptor for the CTXΦ – the filamentous phage which carries the cholera toxin genes into otherwise harmless to human, environmental bacterium V. cholerae. In its natural aquatic habitat V. cholerae is subjec
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22

Gruaz-Guyon, Anne. "Reponse anticorps et protection locale induites par des immunogenes synthetiques selectionnes dans la sequence de la toxine cholerique : immunisation systemique et orale." Paris 6, 1987. http://www.theses.fr/1987PA066409.

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Proposition d'une sequence immunogenique devant contenir des tetrapeptides absents de proteines de l'hote (ou presentant peu d'homologie avec les sequences contenues dans les banques de donnees) en association avec les sequences capables de reconnaitre les antigenes du complexe majeur d'histocompatibilite
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23

Barbarite, Gabrielle M. "The Occurrence of Vibrio vulnificus, V. parahaemolyticus and V. cholerae in the Indian River Lagoon, Florida, with Implications for Human Health." Thesis, Florida Atlantic University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10300318.

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<p> Vibrio bacteria are emerging pathogens responsible for 80,000 illnesses and 100 deaths in the United States each year. Infections are directly linked to the marine environment and are acquired by consuming contaminated seafood or exposing wounds during aquatic activities. Florida has the highest national incidence of vibriosis, with 20% of its cases reported from the Indian River Lagoon region, a popular recreation destination. This study utilized a combination of cultivation and molecular techniques to investigate the local distribution of V. vulnificus, V. parahaemolyticus and V. cholera
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24

Farfán, Sellarés Maribel. "Estudio de la estructura genética de poblaciones de "Vibrio cholerae"." Doctoral thesis, Universitat de Barcelona, 2002. http://hdl.handle.net/10803/2415.

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Se ha estudiado la variabilidad genética de poblaciones de <i>V. cholerae</i> procedentes de distintas fuentes y orígenes geográficos, que agrupan diferentes serogrupos y biotipos de esta especie. Se ha analizado la variabilidad genética a dos niveles: a un nivel proteico, aplicando la técnica de electroforesis de aloenzimas multilocus (MLEE), y a un nivel génico, realizando el análisis de secuencias multilocus (MLST). Con ello, se ha intentado determinar la relación genética existente entre las distintas cepas estudiadas, considerando los datos obtenidos globalmente y por subgrupos de poblaci
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25

Yahyai, Sadaf. "Optimization of a method for testing ballast water for enterococci and an investigation on the occurrence of antibiotic resistance in vibrio cholerae." Thesis, University of Maryland, College Park, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1552707.

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<p> Several methods of enumerating Enterococci in water are suggested in the literature, notably membrane filtration and mEA plating. To establish optimal growth conditions, including incubation time, (24 and 48 hr) and temperature (35&deg;C and 41&deg;C), samples of 0.1 mL, 1 mL and 10 mL filtered water collected from Lake Artemisia, MD, USA were amended with known concentrations of Enterococcus faecalis (ATCC 29212), filtered using 0.45 &micro;m membrane filters, and incubated on mEA agar under different conditions: 35&deg;C/24h, 35&deg;C/48h, and 41&deg;C/48h, following U. S. Environ
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26

Markman, Caroline Viana. "Caracterização de Vibrio cholerae, V. parahaemolyticus e V. vulnificus em amostras da região costeira do estado de São Paulo, de regiões portuárias brasileiras e de tanques de lastro de navios." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-16072009-132501/.

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A poluição, alteração física do habitat e a introdução de espécies invasoras via água de lastro, representam os maiores impactos antropogênicos para os ambientes costeiros. Foram pesquisadas em amostras da região costeira de S. Paulo, regiões portuárias brasileiras e de tanques de lastro de navios, bactérias das espécies Vibrio cholerae (Vc), V. parahaemolyticus (Vp) e V. vulnificus (Vv) que são as que têm maior implicação na saúde pública. As amostras foram avaliadas levando-se em conta parâmetros físico-químicos e microbiológicos e suas relações com a presença de Vc, Vp e Vv. As relações cl
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27

Du, Preez Martella. "Development of novel seminested polymerase chain reaction assays for detecting toxigenic Vibrio cholerae and Shigella spp. in water." Diss., University of Pretoria, 2001. http://hdl.handle.net/2263/26893.

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28

Menezes, Francisca Gleire Rodrigues de. "Caracterização fenotípica e genotípica de bactérias do gênero Vibrio isoladas em alguns estuários do Estado do Ceará." reponame:Repositório Institucional da UFC, 2011. http://www.repositorio.ufc.br/handle/riufc/18711.

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MENEZES, Francisca Gleire Rodrigues de. Caracterização fenotípica e genotípica de bactérias do gênero Vibrio isoladas em alguns estuários do Estado do Ceará. 2011. 94 f. : Tese (doutorado) - Universidade Federal do Ceará, Centro de Ciências Agrárias, Departamento de Engenharia de Pesca, Fortaleza-CE, 2011<br>Submitted by Nádja Goes (nmoraissoares@gmail.com) on 2016-07-26T13:27:46Z No. of bitstreams: 1 2011_tese_fgrmenezes.pdf: 2453594 bytes, checksum: 0370cb8f6e2c333d91e3ccc575df6f2b (MD5)<br>Approved for entry into archive by Nádja Goes (nmoraissoares@gmail.com) on 2016-07-26T13:28:01Z (GMT)
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SÁ, Lena Líllian Canto de. "Diversidade genética de isolados ambientais de Vibrio cholerae da Amazônia brasileira." Universidade Federal do Pará, 2009. http://repositorio.ufpa.br/jspui/handle/2011/4761.

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Submitted by Cleide Dantas (cleidedantas@ufpa.br) on 2014-02-07T11:44:28Z No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Tese_DiversidadeGeneticaIsolados.pdf: 1765217 bytes, checksum: e159b664332d4cd1ed8d170a0a2c6559 (MD5)<br>Approved for entry into archive by Ana Rosa Silva(arosa@ufpa.br) on 2014-02-12T15:56:27Z (GMT) No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Tese_DiversidadeGeneticaIsolados.pdf: 1765217 bytes, checksum: e159b664332d4cd1ed8d170a0a2c6559 (MD5)<br>Made available in DSpace
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Arcidiacono, Diletta. "VCC, citolisina di Vibrio cholerae,promuove secrezione di cloruro dalle cellule intestinali e produzione di citochine TH2 nei mastociti." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425205.

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Cholera has long been considered a classic paradigm of a non-inflammatory toxigenic diarrhoea until Vibrio cholerae infection was found to induce a TH2-type of immune profile and the recruitment of inflammatory cells in the intestinal mucosa (Mathan MM, 1995; Qadri F, 2000). Recent reports indicate increased levels of inflammatory mediators in patients infected by Vibrio cholerae that occur in parallel with recruitment of innate immune cells, including mast cells and neutrophils, in the crypt and villus lamina propria (Qadri F, 2004). Enteropathogenic Vibrio cholerae can elaborate different
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Abd, Hadi. "Interaction between waterborne pathogenic bacteria and Acanthamoeba castellanii /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-569-0/.

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BAHIA, Márcia de Nazaré Miranda. "Caracterização molecular de Vibrio cholerae O1 sacarose negativa de isolados clínicos e ambiente na Amazônia brasileira." Universidade Federal do Pará, 2011. http://repositorio.ufpa.br/jspui/handle/2011/4890.

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Submitted by Cleide Dantas (cleidedantas@ufpa.br) on 2014-02-10T14:29:20Z No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Dissertacao_CaracterizacaoMolecularVibrio.pdf: 3174345 bytes, checksum: 206791fda17f07e3185ab94a45a6791f (MD5)<br>Approved for entry into archive by Ana Rosa Silva (arosa@ufpa.br) on 2014-04-16T15:10:09Z (GMT) No. of bitstreams: 2 Dissertacao_CaracterizacaoMolecularVibrio.pdf: 3174345 bytes, checksum: 206791fda17f07e3185ab94a45a6791f (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5)<br>Made
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Sulca, Lopez Marcos Alejandro. "Identificación y caracterización de integrones y su asociación con la resistencia a antibióticos en cepas de Vibrio spp. aisladas de ambientes marinos contaminados de Lima-Perú." Master's thesis, Universidad Nacional Mayor de San Marcos, 2010. https://hdl.handle.net/20.500.12672/3326.

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La investigación tuvo como objetivo incorporar una metodología de identificación rápida conocida como ARDRA (Amplified Ribosomal DNA Restriction Analysis) para identificar especies del género Vibrio. Se estandarizó la técnica con cepas referenciales. Luego, se aislaron cepas bacterianas asociadas con el cultivo de Litopenaeus vannamei. Posteriormente, se realizaron pruebas bioquímicas para encontrar cepas candidatas de pertenecer al género Vibrio. Al finalizar esta primera etapa, la técnica ARDRA estandarizada, fue aplicada en las cepas candidatas, confirmando de esta manera la factibilidad d
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Vdovikova, Svitlana. "Roles of membrane vesicles in bacterial pathogenesis." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138714.

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The production of membranous vesicles is observed to occur among organisms from all domains of the tree of life spanning prokaryotes (bacteria, archaea) and eukaryotes (plants, animals and fungi). Bacterial release of membrane-derived vesicles (MVs) has been studied most extensively in cases of Gram-negative species and implicating their outer membrane in formation of extracellular MVs. However, recent studies focusing on Gram-positive bacteria have established that they also undergo MV formation. Membrane vesicles are released during normal bacterial growth, they are derived from the bacteria
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35

Baron, Sandrine. "Dynamique de population, diversité génétique et potentiel pathogène de Vibrio cholerae en milieu aquatique anthropisé (estuaire de la Rance en amont de l’usine électrique marée-motrice)." Rennes 1, 2005. http://www.theses.fr/2005REN1S190.

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Vibrio cholerae est une espèce bactérienne aquatique euryhaline. Le but de cette étude est de mieux connaître son écologie et son potentiel pathogène dans le contexte des eaux estuariennes. Dans un cadre géographique et temporel bien défini (estuaire de la Rance en amont de l’usine marée-motrice, six mois à quatre stations d’observation au pas de temps de 14 jours), (i) la modulation de la dynamique de la population de V. Cholerae non toxinogène par certains facteurs environnementaux aquatiques a été observée, et (ii) les variations spatiales et temporelles dans la composition génétique de la
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Thomas, Martha Barnett. "Creation of a viable csrA mutant in Vibrio cholerae." 2013. http://hdl.handle.net/2152/22621.

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Vibrio cholerae, the causative agent of cholera, has been a lethal enteric pathogen to humans for most of recorded history. Even though it is well studied, it still kills many people every year due to rapid and severe dehydrations from diarrhea. Part of what makes V. cholerae such an effective pathogen is its ability to control virulence factors depending on its environment. ToxR is a major virulence protein that has upstream control of most of the virulence genes that are turned on when in a human host. Two of the most critical virulence factors, toxin coregulated pilus and cholera toxin are
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Alodaini, Dema Abdullah. "Blood group O and risk of infection with Vibrio cholerae." Thesis, 2017. https://hdl.handle.net/2144/23761.

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Cholera is an acute diarrheal illness burdening several developing countries caused by toxigenic Vibrio cholerae, where endemics maintain a seasonal pattern and occur more than once a year. Cholera is endemic in certain regions of Africa and South America, and southern Asia, where outbreaks are associated with poor hygiene and sanitary conditions. Every year, 3–5 million cases of cholera are diagnosed, and it causes more than 100,000 deaths worldwide. Cholera toxin is secreted by the V. cholerae bacteria and causes extreme secretory diarrhea, most commonly in poor hygiene environment. Watery
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"Construction and characterization of molecular chimeras of cholera toxin and the heat-labile enterotoxin of Escherichia coli." Tulane University, 2001.

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Cholera toxin (CT) and E. coli heat-labile enterotoxin (LT) have demonstrated potent adjuvant properties in a variety of vaccination strategies. Although similar in structure and function, these molecules exhibit different properties with respect to the nature of the immune enhancement they elicit. Our goal in this study has been to determine the basis for these differences by constructing and characterizing chimeric CT/LT molecules. Plasmids were constructed by subcloning gene fragments, facilitated by site-directed mutagenesis, in order to create two constructs, each expressing the enzymatic
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39

Sarrias, Marion. "Identification des mécanismes de résistance de V. cholerae aux peptides antimicrobiens." Thesis, 2020. http://hdl.handle.net/1866/24513.

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L’organisation mondiale de la santé estime que le choléra entraîne 100, 000 décès par an pour environ 4 millions de cas recensés, plaçant ainsi cette maladie comme un enjeu de santé publique majeur. Cette infection est causée par Vibrio cholerae, une bactérie à Gram négatif vivant en milieu aquatique. Face à cette agression, l’épithélium intestinal et les bactéries du microbiote agissent comme une barrière, en exprimant notamment des peptides antimicrobiens (PAM). V. cholerae, comme de nombreux pathogènes, montre une résistance accrue aux PAM. Malgré une avancée constante sur la compréhe
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Trento, Ilaria. "Genetic elements carrying virulence and antibioticresistant genes: incidence and exchange mechanisms among microorganisms of the marine community also including allochthonous bacterial species of medical interest." Doctoral thesis, 2015. http://hdl.handle.net/11562/909386.

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È risaputo che i batteri possono acquisire geni di antibiotico-resistenza e virulenza attraverso lo scambio orizzontale di geni, e che gli antibiotici selezionano meccanismi di resistenza esistenti e nuove mutazioni che rendono il batterio resistente (Smith et al., 2002). Recentemente sono stati isolati dei ceppi clinici di Vibrio cholerae contenenti geni di antibiotico resistenza rilevati in precedenza in batteri marini (Pande et al., 2012). Inoltre, durante vari studi precedenti condotti nel nostro laboratorio (Labella et al., 2013; Gennari et al., 2012; Caburlotto et al., 2010), era stato
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Cros, Candice. "L'étude des antimicrobiens comme modulateurs du système de sécrétion de type VI de vibrio cholerae." Thèse, 2019. http://hdl.handle.net/1866/22814.

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Quinn, Matthew J. "Molecular and genetic assessment of selected antiporters and methyl-accepting chemotaxis proteins in Vibrio cholerae." Thesis, 2011. http://hdl.handle.net/1957/26906.

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The pathogen Vibrio cholerae uses cations as a primary currency of virulence and environmental persistence, using gradients of those cations to move, acquire nutrients, and control virulence gene expression. An understanding of the overlapping roles of bioenergetics and chemotaxis in the virulence and environmental survival of V. cholerae issues from a large body of prior work, but the interplay of each component is not yet clearly understood. To this end, the activity of the antiporters Vc-NhaP1, Vc-NhaA, and Vc-NhaB was assayed, as was the sodium transporting respiratory pump NQR, and enviro
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REPETTO, Barbara. "Persistance of Vibrio cholerae and other vibrios in the aquatic environment and link with pathogenicity for humans." Doctoral thesis, 2009. http://hdl.handle.net/11562/337499.

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Nei primi anni ’80 un gran numero di evidenze sperimentali ha confermato che i microrganismi, anche patogeni, appartenenti al genere Vibrio sono batteri autoctoni dell’ambiente acquatico. A partire da allora l’ecologia acquatica dei vibrioni è stata largamente studiata ed è stato messo in evidenza come l’ambiente acquatico abbia un ruolo fondamentale nel determinare la persistenza, la disseminazione e l’evoluzione di questi microrganismi, e conseguentemente la loro trasmissione all’uomo. La presenza di vibrioni nell’ambiente acquatico è correlata ai valori di temperatura, di salinità e di ma
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