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Dissertations / Theses on the topic 'Cholesterol and inflammatory molecules'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Lee, Dong-Young. "Modification of high-density lipoprotein 3 by secretory sphingomyelinase, its effects on cholesterol trafficking/ transport, and secretory sphingomyelinase as a protein biomarker for inflammatory disease." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21990.

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Secretory sphingomyelinase (S-SMase), one of the products of acid sphingomyelinase (ASM) or sphingomyelin phosphodiesterase-1 (SMPD-1) gene, hydrolyses sphingomyelin (SM) present in plasma membrane and lipoprotein particles. A number of studies have indicated that S-SMase plays an important role in intracellular or paracrine ceramide second messenger signaling pathways and development of subendothelial atherosclerotic plaque. However, a well-defined function of this enzyme in reverse cholesterol pathway (RCT) in vivo is yet to be elucidated. In this dissertation, we investigated modification

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2

Kanamori, Yohei. "Transcriptional regulation of hepcidin by molecules mediating inflammatory responses." Kyoto University, 2018. http://hdl.handle.net/2433/232336.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第21135号<br>農博第2261号<br>新制||農||1057(附属図書館)<br>学位論文||H30||N5109(農学部図書室)<br>京都大学大学院農学研究科応用生物科学専攻<br>(主査)教授松井徹, 教授久米新一, 教授廣岡博之<br>学位規則第4条第1項該当

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3

Li, L. "The crosstalk between Toll-like receptor signalling and cholesterol homeostasis under inflammatory stress." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1406398/.

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It is proposed that dysregulated cholesterol homeostasis resulting from inflammation and the crosstalk that develops between these two factors are important mechanisms for the progression of both atherosclerosis and chronic kidney disease (CKD). This thesis emphasizes the identification of various pathways of inflammation, Toll-like receptors (TLRs) and dysregulated cholesterol homeostasis. These factors are inter-dependent and interact in initiating foam cell formation in the vascular wall and kidney. THP-1 and HK2 cells were used as in vitro cell models. The roles of myeloid differentiation

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4

Singh, Baljit. "The role of co-stimulatory molecules and inflammatory cytokines in a murine model of inflammatory bowel disease." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275392.

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5

Crone, Elizabeth. "Spatial localisation of oxidative and inflammatory markers within advanced atherosclerotic plaques." Thesis, University of Canterbury. School of Biological Sciences, 2008. http://hdl.handle.net/10092/2259.

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Five atherosclerotic carotid and femoral plaques were sliced longitudinally. Each section was analysed for the concentrations of neopterin, α-tocopherol, TBARS, DOPA, dityrosine, protein carbonyl, protein and cholesterol. The spatial concentrations of the oxidative and inflammatory markers were diverse across and between the individual plaques suggested by the lack of consistent correlations and trends. The only correlation that occurred twice within the individual plaques was a positive correlation between α-tocopherol and cholesterol levels. In the combined plaque analysis which included dat

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6

Bloom, Stuart. "Adhesion molecules in the gastrointestinal tract : a search for cell surface molecules upregulated in inflammatory bowel disease." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239338.

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7

Sakthivel, Priya. "Co-stimulatory molecules : genes to protein in autoimmune and inflammatory disorders /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-425-9/.

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8

Nygård, Mikael. "Effects of aging and inflammatory molecules on the suprachiasmatic circadian clock /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-394-8/.

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9

Smailbegovic, Amir. "The effects of heparin and related molecules on inflammatory cell function." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406674.

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10

Coste, Emmanuel. "Development of small molecules as anti-inflammatory and anti-resorptive drugs." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/9941.

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Rheumatoid arthritis is an auto-immune inflammatory disease that leads to stiff and swollen joints. Patients also have severe bone destruction of the affected joints and another common symptom of rheumatoid arthritis is a generalised bone loss that can lead to osteoporosis. Currently, there are many treatments for rheumatoid arthritis, which provide a recession of the inflammatory symptoms. However, none of these treatments are able to provide a complete protection against the rheumatoid arthritis-induced bone loss. Furthermore, the most effective available treatments such as glucocorticoids o

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11

Wu, Nan. "Regulation of hepatic inflammatory response and lipid metabolism in metabolic disease." The American Physiological Society, 2009. http://hdl.handle.net/1993/23352.

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Hyperhomocysteinemia, an elevation of blood homocysteine levels, is a metabolic disorder associated with dysfunction of multiple organs. Previous studies have shown that hyperhomocysteinemia is related to fatty liver. However, the underlying mechanism remains speculative. The objective of the present study is to investigate the regulatory mechanism of hepatic inflammatory response and cholesterol metabolism during metabolic disorders. In the present study, hyperhomocysteinemia was induced in Sprague-Dawley rats by feeding a high-methionine diet. The mRNA and protein expression of cyclooxygena

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12

Coffey, Lane Claire Katherine. "Immune Cells, Inflammatory Molecules, and CD40 in Nonhuman Primate Islets of Langerhans." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/430.

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Type 1 Diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing beta cells in the pancreas. Amelioration of T1D and the prevention of its detrimental complications are possible through islet transplantation, wherein hormone-producing clusters of cells, islets of Langerhans (islets), are separated from the pancreas and transplanted into a diabetic patient. However, alterations due to the effects of organ recovery, cold ischemia time (CIT), and islet isolation may increase the inflammatory and immunogenic properties of these islets, thereby predisposing the

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13

Garrido, Madalena Frias do Vale. "Avaliação in vivo do potencial de redução de colesterol, da capacidade antioxidante e anti-inflamatória de farelo de arroz." Master's thesis, ISA/UL, 2015. http://hdl.handle.net/10400.5/10956.

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Mestrado em Engenharia Alimentar - Instituto Superior de Agronomia<br>The present work aims to assess the impact of rice bran ingestion, one of the by-products still undervalued by Rice Industry on preventing diseases, in particular to evaluate the in vivo administration of two rice bran stabilized and defatted doses. Thus, rodent animal testing/experiments to evaluate possible initial signs of toxicity were made, as well as the evaluation of the effect of ingestion on cholesterol levels and the antioxidant and anti-inflammatory effect of ingested rice bran. These studies revealed that a singl

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14

Battu, Ganga Rao. "Anti-inflammatory and phytochemical studies of a Kenyan traditional medicinal plant, Commiphora kua." Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366837.

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15

Sade, Asli. "Interaction Of The Non Steroidal Anti-inflammatory Drug Celecoxib With Pure And Cholesterol-containing Model Membranes." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12610749/index.pdf.

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The interactions of the non steroidal anti-inflammatory drug celecoxib with pure and cholesterol containing distearoyl phosphatidylcholine multilamellar vesicles were studied using Fourier transform infrared spectroscopy, differential scanning calorimetry and turbidity technique at 440 nm. The results reveal that celecoxib exerts opposing effects on membrane order in a concentration dependent manner while cholesterol disorders and orders the membrane in the gel and liquid crystalline phase, respectively. Ternary mixtures of DSPC/Cholesterol/celecoxib behave similar to cholesterol with a smal

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16

Bruno, Ferdinando. "Design, synthesis and biological evaluation of new small molecules with anti-inflammatory activity." Doctoral thesis, Universita degli studi di Salerno, 2015. http://hdl.handle.net/10556/1851.

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Per lipossigenasi (nota più comunemente con l'abbreviazione di LOX o LO) si intende una famiglia eterogenea di enzimi in grado di perossidare i lipidi e di causare l'ossigenazione di acidi grassi polinsaturi trasformandoli, così, nei corrispettivi derivati idroperossidici. Nello specifico, la 5-LO rappresenta l'enzima chiave nell'ossidazione dell'acido arachidonico (AA) in LTA4, intermedio indispensabile per la sintesi dei leucotrieni, potenti mediatori flogistici coinvolti in una serie di differenti processi patologici. Va da sé che l'inibizione, dell'attività di tale enzima, induce la dirett

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17

Day, Richard Michael. "Study of the pathogenic significance of epithelial cell adhesion molecules in inflammatory bowel disease." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286598.

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18

Cepeda, Sarah Shealy. "Metal-Assisted Hydrolysis of Biological Molecules." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/chemistry_diss/32.

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In Chapter I is a general description of novel metal complexes which hydrolytically cleave peptides, proteins, DNA, and other biological molecules. These reagents are becoming the more important as potential therapeutic agents. A panel of ligands was investigated for coordination to ZrIV and other metals in groups 4, 5, and 6 to effect the greatest degree of hydrolysis. Chapter II describes a ZrIV complex which is capable of hydrolyzing a 30 amino acid peptide, insulin chain B, with amino acid specificity. Oxidized insulin chain B peptide was hydrolyzed after only 4 h of treatment at pH 7.0 an

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19

Hubler, Zita. "Enhancing Oligodendrocyte Formation via Inhibition of the Cholesterol Biosynthesis Pathway." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1595612178572819.

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20

Ma, Loretta T. K. "PKA Signaling in ABCA1 Function: A Role in Modulation of Cholesterol Efflux and Macrophage Inflammation." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/26272.

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Formation of lipid-laden macrophage foam cells and inflammation are the central components in the initiation and progression of atherosclerosis. ABCA1 is well established as an anti-atherogenic factor that facilitates cellular cholesterol and phospholipid efflux, promotes reverse cholesterol transport, and suppresses pro-inflammatory cytokine secretion. Through these functions, ABCA1 is capable of reducing the lipid burden in atherosclerotic plaque. PKA signaling is an integral factor in promoting many anti-atherogenic functions of ABCA1; however, mechanistic aspects of PKA signaling associate

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21

Arguello, Meztli. "Primary effusion lymphoma : disruption of the B cell transcriptional program and overexpression of inflammatory molecules." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103020.

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Primary Effusion Lymphoma (PEL) is a lymphoproliferative disease of B cell origin associated with HHV-8 infection and characterized by migration of tumor cells to serous body cavities. PEL cells originate from post-germinal center B cells yet harbor a non-B, non-T phenotype, a characteristic that has not been fully explained. In the present study we demonstrate that PEL cells have an impaired expression of B cell-specific transcription factors and this results in a decreased activity of promoters regulating essential B cell genes. PEL cells lack PU.1 expression, although its transcription part

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22

Selby, Anna Louise. "Identification of novel T-cell surface molecules that induce inflammatory cytokine production in human monocytes :." Thesis, St George's, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423142.

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23

Morandi, Mattia. "Disruption of model membranes' phase behavior upon interaction with hydrophilic/hydrophobic molecules." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAE041/document.

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Ce travail concerne l’altération du comportement de phase de membranes lipidiques lors de leur interaction avec des molécules hydrophiles ou hydrophobes. L’utilisation de sondes moléculaires de fluorescence sensibles à leur micro-environnement constitue un aspect majeur de ce travail. Les techniques de spectroscopie de fluorescence et de microscopie confocale ont été mises à profit pour l’étude du comportement de ces sondes, donnant accès au degré de compacité et d’ordre dans les membranes.Nos résultats montrent que le polystyrène, un plastique rencontré de façon commune dans les régions pollu

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24

Prins, Louis Hendrik Albertus. "Polycyclic cage compounds as carrier molecules for neuroprotective non-steroidal anti-inflammatory drugs / Louis H.A. Prins." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1479.

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25

Mesri, Mehdi. "T lymphocytes-blood retina barrier cells interactions in vitro : the role of adhesion molecules and inflammatory mediators." Thesis, University of Aberdeen, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320782.

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The BRB consists of both capillary endothelial cells (REC) and retinal pigment epithelial cells (RPE). Both cell types have been suggested as potential activators of circulating T cells. In this study, an <I>in vitro</I> model using cultured rat REC and syngeneic T cells was developed. Furthermore RPE and for the purpose of comparative studies, AEC were also successfully cultured. It was demonstrated that activation of T lymphocyte LFA-1 is a critical event governing the adhesion of T cells to RPE and REC as IFN-γ induced up-regulation of RPE and REC ICAM-1 expression did not increase binding

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26

Nakao, Tetsushi. "Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-inflammatory Pathways." Kyoto University, 2018. http://hdl.handle.net/2433/231004.

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27

Telford, Erica. "Dual role of three natural molecules in regulating the expression of β-defensin-3 and pro-inflammatory mediators". Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC273.

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Les peptides antimicrobiens (PAMs) sont des effecteurs de la réponse innée produits et sécrétés par les cellules épithéliales intestinales. A l’interface entre l’épithélium et les microbes, ils représentent un élément important de la barrière muqueuse. Certains PAMs, tels que la bêta-défensine humaine 1 (BDH-1), sont exprimés de manière constitutive, tandis que d'autres PAMs, dont la BDH-2 et la BDH-3, sont induits par des signaux dérivés des microbes et de l'hôte. Les PAMs contrôlent la densité des bactéries commensales dans la lumière intestinale ainsi que la capacité invasive des agents pat

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28

Potenza, Marianna. "Computational chemistry techniques for the design and the synthesis of molecules with anti-inflammatory and anti-tumor activity." Doctoral thesis, Universita degli studi di Salerno, 2019. http://elea.unisa.it:8080/xmlui/handle/10556/4270.

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2017 - 2018<br>In the last few years, computational chemistry has played an important role in disclosing novel compounds with relevant biological activity. Inflammation and cancer processes have been recently linked, and the identification of new molecular entities able to interfere with biological targets involved in these pathologies is strongly needed. The analysis of ligand-macromolecule interactions and the evaluation of possible “binding modes” are the starting points in the design and the identification of new and more powerful drugs. Also, in silico Virtual Screening campaigns of large

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Albtoush, Nansy. "Inhibiting the Function of TSG-6 in Inflammatory Models as a Possible Therapeutic Intervention." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1544060182841309.

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30

Parekh, Gita. "Leukocyte-mediated degradation of lung extracellular matrix & serum molecules in chronic inflammatory disease, as discerned through urinary biomarkers." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/120257/.

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Chronic Obstructive Pulmonary disease (COPD) is an irreversible inflammatory disease of the lung, characterised by abnormal inflammation of the lungs in response to inhalation of noxious particles or toxic gases, especially cigarette smoke. COPD exacerbations, defined as acute sustained worsening of symptoms from usual stable state, accounts for significant morbidity and mortality. Improved diagnostics which give advanced warning of an exacerbation could help prevent further declines in lung function. The quest to identify a marker or a combination of markers associated with COPD exacerbations

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31

Frasson, Alvise. "Analysis of the Expression of Pro-Inflammatory Cytokines and Vascular Adhesion Molecules in Cirrhotic Patients with or without Hepatocarcinoma." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3426211.

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Background: Hepatocarcinoma (HCC) is the fifth most commonly diagnosed cancer and the second cause of cancer death in men worldwide, while in women represents the seventh most frequently diagnosed cancer and the sixth leading cause of cancer related death. HCC incidence is 10-20/100.000 per year and its mortality rate is 16/100.000 per year. 70-90% of patients are affected by liver cirrhosis and indeed this represents the greatest risk factor for HCC. Worldwide almost 54% of HCC is attributable to HBV infections, while 30% are caused by HCV and 15% by alcohol consumption. During progression fr

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32

Moshfegh, Ali. "The biological mechanisms in neutrophil and eosinophil adhesion and transmigration in vitro and their relation to the inflammatory process in vivo /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-122-5/.

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33

Hatta, Ichiro, Susumu Okazaki, Kimiko Oono, and Yoshimichi Andoh. "A molecular dynamics study of the lateral free energy profile of a pair of cholesterol molecules as a function of their distance in phospholipid bilayers." AIP Publishing, 2012. http://hdl.handle.net/2237/20839.

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34

Eduardo, Da Silva Acarilia. "Nanotechnological delivery systems for the oral administration of active molecules : Polymeric microparticles and microemulsions applied to anti-inflammatory and anti-infectious drugs." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00856598.

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This thesis was devoted to the development of innovative oral delivery systems for two different molecules. In the first part, microparticles (MPs) based on xylan and Eudragit® S-100 were produced and used to encapsulate 5-aminosalicylic acid for colon delivery. Xylan was extracted from corn cobs and characterized in terms of its physicochemical, rheological and toxicological properties. The polymeric MPs were prepared by interfacial cross-linking polymerization and spray-drying and characterized for their morphology, mean size and distribution, thermal stability, crystallinity, entrapment eff

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Silva, Acarilia Eduardo da. "Nanotechnological delivery systems for the oral administration of active molecules: Polymeric microparticles and microemulsions applied to anti-inflammatory and anti-infectious drugs." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13309.

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Made available in DSpace on 2014-12-17T14:13:48Z (GMT). No. of bitstreams: 1 AcariliaES_TESE.pdf: 9221805 bytes, checksum: 71876e327362584aeb9dcac7d3652c4d (MD5) Previous issue date: 2013-04-05<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>This thesis was devoted to the development of innovative oral delivery systems for two different molecules. In the first part, microparticles (MPs) based on xylan and Eudragit? S- 100 were produced and used to encapsulate 5-aminosalicylic acid for colon delivery. Xylan was extracted from corn cobs and characterized in terms of its phy

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36

BREUGNOT, CHRISTINE. "Peroxydation des lipoproteines de basse densite et atherosclerose : effet protecteur des molecules amphiphiles et etude in vitro de l'accumulation des esters de cholesterol par les macrophages." Paris 6, 1991. http://www.theses.fr/1991PA066435.

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La peroxydation des lipoproteines de basse densite est une etape importante dans la formation de la plaque d'atherome. La recherche de molecules pouvant l'inhiber sont des enjeux essentiels de la recherche pharmaceutique. La modification des ldl peut etre induite in vitro en presence de cellules endotheliales, de monocytes ou d'ions cu#2#+. Dans cette etude, nous avons montre que certaines molecules depourvues d'activite antioxidante protegent les ldl de la peroxydation par le cuivre ou les cellules endotheliales. C'est le cas des phenothiazines et de certains antagonistes calciques. Cet effet

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Zara, Carolina. "Fine-tuning of intracellular redox state by pro-glutathione molecules modulates the cellular immune/inflammatory response to infections: in vivo and in vitro studies." Doctoral thesis, Urbino, 2020. http://hdl.handle.net/11576/2681328.

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38

Quercini, Leila. "The antimicrobial peptide SET-M33. Characterization of back-up molecules for the setup of novel antibiotics and development of a medical device for removing bacterial toxins from blood." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1070198.

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The increasing frequency of multidrug-resistant (MDR) and extensively drug- resistant pathogens creates an urgent need for new antimicrobial drugs and new strategies for the treatment of infectious diseases The peptide SET-M33 is currently under preclinical development for the set-up of a new antibacterial agent to treat infections caused by Gram-negative pathogens. It is a cationic non-natural peptide synthetized in a tetra-branched form that makes it more resistant to degradation in biological fluids. SET-M33 has broadly shown high antimicrobial activity, both in vitro and in vivo, anti-infl

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Amsalem, Muriel. "Le canal Nav1.9, un acteur de la douleur inflammatoire régulé par le cholestérol : mécanisme d'action et perspectives thérapeutiques." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5008.

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La prise en charge de la douleur est un enjeu médical majeur car il existe toujours des douleurs réfractaires aux traitements antalgiques actuels. La détection de la douleur est assurée par les neurones nociceptifs dont l'excitabilité est majoritairement contrôlée par les canaux sodiques dépendants du potentiel (Nav). Parmi eux, le canal Nav1.9 se distingue par son expression restreinte dans les nocicepteurs et par ses caractéristiques électrophysiologiques qui lui confèrent un rôle particulier dans l'électrogenèse de ces neurones. Au cours de ce travail de thèse nous avons caractérisé le rôle

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Huang, Tzu-Hsuan. "Fusion of anti-HER2/neu with inflammatory cytokines IFN-a and TNF-a results in molecules that elicit an anti-tumor response or potentiate wound healing." Diss., Restricted to subscribing institutions, 2006. http://proquest.umi.com/pqdweb?did=1276406491&sid=11&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Bonato, M. "A PILOT STUDY OF BRISK WALKING IN SEDENTARY CART-TREATED PATIENTS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/258148.

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Antiretroviral treatments (ART) have dramatically reduced HIV infection mortality, transforming HIV infection into a chronic disease requiring life-long treatment. Sadly, treatment is associated with a number of metabolic, cardiovascular, osteoarticular, renal and central nervous system toxicities. Moreover, Chronic HIV infection is associated with low-level inflammation and increased risk of chronic diseases and mortality. As a result, long-term treated patients may present with increased risk of cardiovascular and cerebrovascular disease, lypodystrophy, early diabetes, kidney failure, osteop

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42

Raut, Nilesh G. "BIOSENSING SYSTEMS FOR THE DETECTION OF BACTERIAL QUORUM SENSING MOLECULES: A TOOL FOR INVESTIGATING BACTERIA-RELATED DISORDERS AND FOOD SPOILAGE PREVENTION." UKnowledge, 2012. http://uknowledge.uky.edu/chemistry_etds/13.

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Quorum sensing enables bacteria to communicate with bacteria of the same or different species, and to modulate their behavior in a cell-density dependent manner. Communication occurs by means of small quorum sensing signaling molecules (QSMs) whose concentration is proportional to the population size. When a QSM threshold concentration is reached, certain genes are expressed, thus allowing control of several processes, such as, virulence factor production, antibiotic production, and biofilm formation. Not only many pathogenic bacteria are known to produce QSMs, but also QSMs have been identifi

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Vilela, rodrigues Thaís. "Caractérisation de la protéine MAM (Microbial Anti-inflammatory Molecule) du genre Faecalibacterium : structure, diversité et implications anti-inflammatoires." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASB023.

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La Microbial Anti-inflammatory Molecule (MAM) est une protéine unique produite par le genre Faecalibacterium, un groupe clé de bactéries commensales du microbiote intestinal humain. Parmi elles, Faecalibacterium duncaniae (anciennement F. prausnitzii) est particulièrement abondante et étroitement associée à l'homéostasie intestinale et à la santé générale. MAM a démontré des propriétés anti-inflammatoires significatives ; cependant, ses caractéristiques moléculaires et fonctionnelles, ainsi que ses mécanismes d'action, restent encore mal compris. Ce travail vise à étudier le rôle physiologique

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Belinati, Karen Daher. "Efeitos do ácido clorogênico sobre funções de neutrófilos: estudos in vitro." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-31012011-135341/.

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Ácido clorogênico (ACG) é o termo utilizado para designar um grupo de compostos fenólicos oriundos da reação de esterificação entre ácidos hidroxicinâmicos (p-cumárico, caféico e ferúlico) e ácido quínico. São amplamente encontrados em produtos naturais e exercem ações antioxidantes, citotóxicas, antitumorais, antibacterianas, antifúngicas e antiinflamatórias. Apesar da descrição dos seus efeitos antiinflamatórios em diferentes modelos experimentais, a literatura é carente quanto suas ações específicas em funções inflamatórias de neutrófilos. Assim, o objetivo do presente trabalho foi investig

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Silveira, Angélica Aparecida Antoniellis 1987. "Investigação do papel do óxido nítrico e de Rho GTPases na adesão de neutrófilos sob condições inflamatórias = Investigation of the role of nitric oxide and Rho GTPases in neutrophils adhesion under inflammatory conditions." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311498.

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Orientador: Nicola Amanda Conran Zorzetto<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T05:53:22Z (GMT). No. of bitstreams: 1 Silveira_AngelicaAparecidaAntoniellis_M.pdf: 1268408 bytes, checksum: 22c750391706cfa07cb1fd66d9e8a9c1 (MD5) Previous issue date: 2012<br>Resumo: Durante a resposta inflamatória, os neutrófilos e outros leucócitos aderem ao endotélio, deixando os vasos sanguíneos e movimentando-se ativamente em direção ao foco inflamatório. A migração dos neutrófilos para sítios inflamatórios depe

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Pinedo, Fernanda Júdice. "Efeitos da hidroquinona sobre atividades funcionais da célula endotelial e de neutrófilos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-15012010-130114/.

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A hidroquinona (HQ) é um composto fenólico obtido a partir da metabolização endógena do benzeno, está presente no cigarro, medicamentos, reveladores fotográficos, alimentos e plantas medicinais. Temos demonstrado que a intoxicação experimental de ratos à HQ compromete a migração de leucócitos para o pulmão na vigência de resposta inflamatória alérgica ou inespecífica. O presente trabalho visou avaliar os efeitos da HQ sobre atividades da célula endotelial e de neutrófilos envolvidas na inflamação. Culturas primárias de células endoteliais da rede microcirculatória obtidas do músculo cremaster

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Gnansounou, Senankpon Martial. "Etude des activités anti-inflammatoire, antioxydante et screening par chromatographie gazeuse couplée à la spectrométrie de masse d’extraits éthanoliques de trois fabacées du Bénin : isolement de molécules bioactives." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0603.

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Face à la résurgence de pathologies infectieuses, notre étude a porté sur le potentiel thérapeutique de Dialium guineense, Parkia biglobosa et Tamarindus indica afin de rechercher des molécules bioactives pouvant contrer l’antibiorésistance ou ses corolaires. L’état de l’art des molécules bioactives des trois plantes a montré que de nombreuses familles de composés sont identifiées dans différents organes aériens. Toutefois le lien avec les activités biologiques reste non élucidé. Ensuite, nous avons évalué quelques activités biologiques des extraits éthanoliques ou hydro-éthanoliques des feuil

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D'ORAZIO, GIUSEPPE. "Glycoderivatives: drug candidates and molecular tools." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/41154.

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The research project is focused on the development and the synthesis of glycoderivatives as potential drug candidates, for therapeutic use, and as molecular tools, for the study of biological processes. The project includes the study of SGLT1 (Sodium-Glucose co-transporter 1), its role in inflammatory processes and the development of potential carbohydrate-based anti-inflammatory agents. Furthermore, new glycoderivatives and glycoconjugates will be synthetized for other potential pharmacological applications such as the targeting of cytotoxic drugs, as novel potential anticancer agents, and f

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Van, Antwerpen Pierre. "Contribution à l'étude du pouvoir antioxydant de divers agents d'intérêt thérapeutique: ciblage du système myélopéroxydase/péroxyde d'hydrogène/chlorure." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210755.

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<p align="justify">The production of reactive oxygen species is strictly kept under control in the Human body. However, several conditions are characterized by the over-production or the uncontrolled production of these species, promoting damage to the host tissue. Among oxygen species producer, the myeloperoxidase/hydrogen peroxide/chloride system is a key element. This the consequence of the large quantity of myeloperoxidase found in neutrophils and that can be released rapidly during an inflammatory process. Moreover, hypochlorous acid, synthesized by this system, is a powerful oxidant.</p>

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Hebeda, Cristina Bichels. "Inibição in vivo das óxido nítrico sintases: efeitos sobre a expressão de moléculas de adesão e secreção de mediadores inflamatórios." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-26012009-223227/.

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Resultados preliminares do nosso grupo de pesquisa demonstraram que a inibição da síntese de NO por período de tempo prolongado reduz o recrutamento de leucócitos para focos inflamatórios, dependente, pelo menos em parte, da inibição da interação leucócito-endotélio e da expressão de L-selectina. 0 presente trabalho visou complementar os estudos sobre os mecanismos envolvidos nesta ação antiinflamatória. Para tanto, ratos Wistar machos (180 a 220g) receberam L-NAME (20mg/Kg; v.o.; 14 dias) ou água pela mesma via e período de tempo. Foi avaliada a atividade das enzimas óxido nítrico sintases (N

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