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Dissertations / Theses on the topic 'Cholesterol'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Edington, J. "The relationship of dietary cholesterol to plasma cholesteroll." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236284.

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2

Malcolmson, Richard Joseph. "Physical studies of cholesterol and cholesteryl esters in model membranes." Thesis, Edinburgh Napier University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385910.

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3

Velarde, Laos Edmundo, and Ana Gonzalez. "Cholesterol and Cholesterol Oxides in Chicken Meat." Revista de Química, 2012. http://repositorio.pucp.edu.pe/index/handle/123456789/99119.

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Se determinó el contenido de lípidos totales, colesterol yóxidos de colesterol en carne de pollo adquiridos en 3avícolas de Lima. La carne de pollo presentó valores de lípidostotales y colesterol diferentes porpresentó los menores valores demientras que la piel presentó losavícola. La carne de pecholípidos totales y colesterol,mayores valores de estos. Por cromatografía de gases acoplado a espectrómetro demasas (CG-EM) se confirmó la estructura de los siguientes óxidosde colesterol: 7-cetocolesterol, en las 3 avícolas; 7 β -hidroxicolesterol en ala de la avícola 1 y piel de la avícola 2; 7 -hi

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4

Kingdon, Lorraine B. "Speedy Cholesterol." College of Agriculture, University of Arizona (Tucson, AZ), 1990. http://hdl.handle.net/10150/295659.

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5

Famer, Daniel. "Implications of cholesterol and cholesterol-lowering therapy in Alzheimer's disease /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-260-6/.

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6

Burkett, Paul A. "Frequent cholesterol feedback as an aid in lowering cholesterol levels." Thesis, Virginia Tech, 1989. http://hdl.handle.net/10919/44704.

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Twenty six male and two female participants in the Cardiac Therapy Program at Virginia Tech were stratified, based upon level of total cholesterol (TC) and length of time in the Cardiac Program, and then randomly assigned to either experimental or control groups. Participants ranged in age from 43 to 68 years and all had baseline TC levels greater than 200 mg/dl. There were no significant differences between groups in terms of baseline TC (control M : 248 mg/dl; experimental M = 251 mg/dl), blood pressure (BP), weight, predicted percent body fat, dietary fat/cholesterol, age, education, or

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7

Alasmi, Mahmood Mohamed. "EFFECTS OF CHOLESTEROL SUPPLEMENTATION ON CHOLESTEROL SYNTHESIS RATES IN INFANTS." University of Cincinnati / OhioLINK, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=ucin974741712.

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8

Norlin, Maria. "Cytochrome P450 Enzymes in the Metabolism of Cholesterol and Cholesterol Derivatives." Doctoral thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1086.

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<p>Cholesterol is metabolized to a variety of important biological products in the body including bile acids and vitamin D. The present investigation is focused on enzymes that catalyze 7α-hydroxylation or 27-hydroxylation in the metabolism of cholesterol, oxysterols (side chain-hydroxylated derivatives of cholesterol) and vitamin D<sub>3</sub>. The enzymes studied belong to the cytochrome P450 enzyme families CYP7 and CYP27.</p><p>The study describes purification of a cytochrome P450 enzyme fraction active in 7α-hydroxylation of 25-hydroxycholesterol, 27-hydroxycholesterol, dehydroepiandroste

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9

Trevenen, Alexandra H. "Investigations of phospholipid/cholesterol and cholesterol derivative interactions in model membranes." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5582.

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Multinuclear solid state MAS NMR (1H and 31P), 31P CSA solid state NMR, 2H NMR and x-ray diffraction techniques have been used to compare the structure and properties of DPPC: Andro and DPPC: 4β-hydroxycholesterol with that of the properties known of DPPC: Chol mixtures in excess water. The formation of the Lo phase is known to occur with PC: Chol mixtures with sufficient concentrations of cholesterol. The formation and properties of the Lo phase was looked at with the cholesterol derivatives Andro (lacking in the hydrocarbon tail present in cholesterol) and 4β-hydroxycholesterol (possessing a

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10

Beehler, Kaitlyn. "MiR-1908 Is a Cholesterol Responsive MicroRNA Implicated In Cholesterol Regulation." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40422.

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Leveraging miRNA-Seq data and the 1000 Genomes imputed genotypes, we identified rs174561-C as a strong miRQTL for circulating miRNA-1908-5p (P=4.8x10-31) which has an inverse relationship with circulating LDL-C, fasting glucose and A1c. Here I investigated the molecular mechanism(s) linking miR1908-5p to cholesterol metabolism. First, by overexpression experiments in HuH-7 cells demonstrate that the presence of the C allele, associated with lower LDL-C levels, significantly increases miR-1908-5p by 2.15-fold relative to the T allele. Further experiments revealed that 72-hour cholesterol deplet

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11

Jiang, Zhao-Yan. "Studies on cholesterol and bile acid metabolism in Chinese cholesterol gallstone patients." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-844-0/.

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12

Lubchak, I. V., and A. Koneva. "Inhibitors for cholesterol reduction." Thesis, Sumy State University, 2016. http://essuir.sumdu.edu.ua/handle/123456789/45956.

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Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels. Many of them involve atherosclerosis, which causes most heart attacks and strokes. Cardiovascular diseases are the leading cause of death globally. Nearly 2,200 Americans die of cardiovascular disease daily, with an average of one death occurring every 40 seconds. However, elevated levels of certain forms of cholesterol are some of the primary drivers in the development of some CVDs.

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13

Wassif, Christopher A. "Dysregulation of cholesterol homeostasis." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:da3374f0-9285-4490-b2e7-af493556d925.

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Cholesterol plays a critical role in the health and normal function of every mammalian cell. Cholesterol has multiple cellular functions including maintenance of cell membrane stability and fluidity, steroid hormone and bile acid synthesis, and membrane receptor signaling. As with any critical metabolite, cholesterol is highly regulated. I will detail my research focusing on the two prevalent disorders of cholesterol homeostasis. The first is a disorder of cholesterol biosynthesis, Smith-Lemli-Opitz syndrome (SLOS), and the second a disorder of cholesterol trafficking, Niemann-Pick disease, ty

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14

Shie, Feng-Shiun. "Cholesterol and Alzheimer's disease /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/6604.

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15

Misner, Scottie, Carol Curtis, and Evelyn Whitmer. "Fat and Cholesterol Update." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2006. http://hdl.handle.net/10150/146439.

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2 pp.<br>Of all the nutrients in the food supply, fat and cholesterol probably receive the most attention from health professionals and the public alike. The scientific evidence is clear that a high-fat diet relates to chronic health problems such as heart disease, some types of cancer, diabetes, and obesity. But both fat and cholesterol are natural components of the body that are vital to good health, and too little fat in your diet is just as unhealthy as too much. This article reviews dietary fats and provides guidelines for choosing foods to balance the type and amount of fat in your diet.

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16

Wang, Li Ph D. Massachusetts Institute of Technology. "Cholesterol and egg activation." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122709.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2019<br>Cataloged from PDF version of thesis. Page 236 blank.<br>Includes bibliographical references.<br>The high-density lipoprotein (HDL) receptor SR-BI controls the structure and fate of plasma HDL. The SR-BI knockout (KO) females are infertile, apparently due to their abnormal, cholesterol-enriched HDL particles. In this thesis, my colleagues and I examined the growth and meiotic progression of SR-BI KO oocytes and found that they underwent normal germinal vesicle breakdown; however, SR-BI KO eggs, which had accu

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17

Ridgen, Julie Elizabeth. "The effect of exercise and dietary cholesterol on cholesterol synthesis in the hamster." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27627.

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Physical inactivity and elevated plasma cholesterol are well characterized risk factors for the development of coronary heart disease (CHD). Consequently, manipulation of exercise intensity and dietary cholesterol may favourably alter lipid metabolism to reduce this risk. The present study examined both independent and interactive effects of exercise and dietary cholesterol on in vivo hepatic and intestinal cholesterol synthesis as well as plasma total and high density lipoprotein (HDL) cholesterol levels in hamsters. Male Syrian hamsters were randomized into one of i) low dietary cholesterol

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18

Bayley, Timothy M. "The longer term effect of early dietary cholesterol on cholesterol metabolism in infants." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0016/MQ44125.pdf.

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19

Demmers, Thea. "Longer-term effects of early cholesterol intake on cholesterol biosynthesis and plasma lipids." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18193.

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Endogenous cholesterol (Ch) fractional synthesis rate (FSR) is inversely related to infant dietary Ch at 4 months (mo) of age. The objective of the present study was to determine whether level of infant dietary Ch induced changes in FSR that persisted at 18 mo. Forty-seven infants received, human milk (HM) from birth until weaned (n=15), or were randomized to receive modified cow-milk formula (MCF) with added Ch (n=15), or cow-milk formula (CF, n=17), for 12 mo. Ch contents of HM, MCF, and CF were 120, 80, and 40 mg/L, respectively. At 4 mo, FSR in the HM group was lower than in CF, but at

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20

Bayley, Timothy M. "The longer term effect of early dietary cholesterol on cholesterol metabolism in infants /." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37522.

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La synthese endogene du cholesterol (CH) a ete etudie chez 81 nouveau-nes, ages de 4 mois (BRAS 1) ou de 11 a 12 mois (BRAS2), afin d'evaluer les effets a long terme d'un supplement de CH sur l'homeostasie du CH. BRAS 1 etait compose de 32 nouveau-nes recevant soit du lait humain (HUM) (6M, 7F), une formule a base de lait de vache (VAC) (6M, 3F) contenant 3.5 mg CH/dl, ou une formule a base de lait de vache modifiee (VACM) (6M, 7F) contenant 13.5 mg CH/dl, afin d'evaluer l'effet du supplement sur les taux de synthese du CH. BRAS2 etait compose de 49 autres enfants recevant soit HUM (11M, 6F),

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21

Guérin, Maryse. "Transport inverse du cholesterol : roles de la lecithine cholesterol acyltransferase (lcat) et de la proteine de transfert des esters de cholesterol (cetp)." Paris 6, 1994. http://www.theses.fr/1994PA066136.

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Dans le compartiment plasmatique les lipoproteines de basse densite assurent l'approvisionnement en cholesterol des tissus extra hepatiques. Les tissus peripheriques sont cependant incapables de degrader le cholesterol ainsi accumule. Dans ces conditions, l'homeostasie du cholesterol ne peut etre maintenue que grace a un systeme d'epuration et de transport vers le foie. Cette voie de retour du cholesterol, des tissus peripheriques vers le foie, est nommee transport reverse du cholesterol. Ce systeme peut etre divise en plusieurs etapes. La premiere constitue l'efflux du cholesterol cellulaire.

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22

Mahammad, Saleemulla. "Cholesterol in T cells homeostasis, plasma membrane organization and signaling /." Doctoral thesis, Stockholm : The Wenner-Gren Institute, Stockholm University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-38357.

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Diss. (sammanfattning) Stockholm : Stockholms universitet, 2010.<br>At the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 2: Manuscript. Paper 3: In press.

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23

Marijanovic, Zrinka. "Cellular requirements for cholesterol and identification of genes involved in cholesterol biosynthesis and homeostasis." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966109104.

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24

Grebe, Alena [Verfasser]. "Targeting cholesterol crystals in atherosclerosis with cholesterol solubilizing 2-hydroxypropyl-beta-cyclodextrin / Alena Grebe." Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/1124540296/34.

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25

Shen, Haiqing. "New candidate gene involved in reverse cholesterol transport (RCT) : the case for phospholipid transfer protein (PLTP): interactions with dietary factors /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2004.

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Thesis (Ph.D.)--Tufts University, 2004.<br>Adviser: Jose Ordovas. Submitted to the School of Nutrition Science and Policy. Includes bibliographical references (leaves 136-137). Access restricted to members of the Tufts University community. Also available via the World Wide Web;

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26

Al-Seeni, Madeha N. "Control of hepatic cholesterol esterification." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293154.

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27

Kacher, Radhia. "Role of the cholesterol hydroxylase enzyme CYP46A1 in cholesterol metabolism and neuroprotection in Huntington's disease." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS154.

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La maladie de Huntington (MH) est une maladie génétique autosomique dominante, causée par une augmentation du nombre de CAG sur le gène de la huntingtin. L’homéostasie du cholestérol cérébral est altérée dans la MH. L’expression de CYP46A1, enzyme neuronale catabolisant le cholestérol dans le cerveau, est diminuée dans le putamen des patients et dans le striatum de souris modèles de la MH. Après restauration de l’expression de CYP46A1 dans le striatum des souris Knock-In zQ175, les capacités locomotrices sont améliorées, l’agrégation de la huntingtine mutée est diminuée, l’atrophie neuronale e

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28

Devadoss, Anando. "Cholesterol Oxidase Modified Microelectrodes for Detection of Cholesterol in the Plasma Membrane of Single Cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1126199194.

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29

Paredes-Aramburú, Jacqueline, and Antonio Bernabe-Ortiz. "Asociación entre la participación en programas de asistencia alimentaria y patrones del perfil lipídico en Perú." Sociedad Chilena de Nutricion Bromatologia y Toxilogica, 2018. http://hdl.handle.net/10757/624651.

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Purpose: To assess whether the participation in food assistance programs (Community Kitchens and Glass of Milk) was associated with lipid profile patterns in the Peruvian population. We conducted a secondary data analysis using data from the National Survey of Nutritional, Biochemical, Socioeconomic, and Cultural Indicators related to Chronic Degenerative Diseases. The sample included individuals aged ≥20 years, selected from five geographic strata in Peru. From each stratum a random sample of clusters was chosen. Different Poisson regression models with robust variance were built to determine

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30

Macklin, Diana C. "A comparison of cholesterol measurements via various blood sample types." Virtual Press, 1991. http://liblink.bsu.edu/uhtbin/catkey/774768.

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There has been inconsistencies in the performance of dry-chemistry analyzers using different blood sample types. Therefore, the purpose of this study was to determine precision and accuracy of both capillary and venous whole blood analyzed by the Reflotron (Boehringer Mannheim Diagnostics, Indianapolis, Indiana) and capillary plasma analyzed by the Ektachem DT60 (Eastman Kodak Company, Rochester, New York). Fifty subjects were recruited to provide a representative sample of cholesterol concentrations. One technician performed two fingerstick punctures and one venipuncture on each subject and a

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31

McMullen, Todd Patrick William. "Physical studies of cholesterol-phospholipid and cholesterol-glycolipid interactions in model and Acholeplasma laidlawii B membranes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq21603.pdf.

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32

Sabeva, Nadezhda Steliyanova. "REGULATION OF ABCG5 AND ABCG8 STEROL TRANSPORTERS IN BILIARY CHOLESTEROL ELIMINATION, REVERSE CHOLESTEROL TRANSPORT AND DYSLIPIDEMIA." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/193.

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ATP-binding cassette transporters ABCA1 and ABCG1 initiate reverse cholesterol transport generating HDL particles, whereas ABCG5/G8 promote biliary cholesterol secretion thereby facilitating the last step of reverse cholesterol transport. Mutations in the leptin axis result in obesity and dyslipidemia in ob/ob and db/db mice. These mice have defective HDL clearance, increased plasma cholesterol and decreased biliary cholesterol elimination. My studies demonstrate that ABCG5/G8 protein is low in these animals and can be restored with caloric restriction or leptin replacement. To directly test w

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33

Volk, Catherine B. "Role of inhibition of protein prenylation in the cholesterol-dependent and cholesterol-independent effects of simvastatin." Virtual Press, 2006. http://liblink.bsu.edu/uhtbin/catkey/1339597.

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Statins are widely used to treat hypercholesterolemia. Statins inhibit cholesterol biosynthesis, thereby activating genes involved in cholesterol homeostasis, which are under the control of the Sterol Regulatory Element (SRE). Statins also have cholesterol-independent beneficial cardiovascular effects mediated through the phosphoinositide 3-kinase (PI3-K) / Akt signaling pathway and by inhibition of protein prenylation. Because statins inhibit the synthesis of isoprenoids, they can act by inhibiting the small signaling GTPases Ras and Rho, which require post-translational prenylation to become

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34

Blanco, Carlos. "Theoretical effects of decreasing saturated fat and cholesterol intake on total serum and LDL Cholesterol Levels /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu148793324553977.

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35

LEVASSEUR, DANIELLE. "Etude de la regulation de la biosynthese du cholesterol par des derives endogenes oxydes du cholesterol." Université Louis Pasteur (Strasbourg) (1971-2008), 1996. http://www.theses.fr/1996STR13251.

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Les maladies coronariennes sont la principale cause de mortalite dans les pays industrialises. L'hypercholesterolemie constitue l'un des facteurs de risques majeurs de ces pathologies. L'une des solutions adoptees en therapie consiste a reduire le taux de cholesterol circulant. Parmi les substances hypocholesterolemiantes, les inhibiteurs de la 3-hydroxy-3-methylglutaryl-coa reductase (hmgcoa reductase), enzyme regulatrice principale de la voie de biosynthese du cholesterol, sont les plus employes a ce jour. Cependant l'inhibition de la biosynthese a un stade plus tardif peut etre envisagee. A

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36

Mitter, Diana. "Cholesterol und der Synaptophysin-Synaptobrevin-Komplex." Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=966236181.

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37

Tan, Qiulin. "Inhibition of cholesterol biosynthesis under hypoxia." Texas A&M University, 2005. http://hdl.handle.net/1969.1/3101.

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Oxygen balance is very important and tightly regulated in mammals. Under hypoxia, hypoxia inducible factor 1(HIF-1) dimerizes with hypoxia inducible factor 1± (HIF-) and activates expression of several genes. Using a mammalian two hybrid assay, we found that HIF-1 interacted with sterol response element binding protein 1a (SREBP1a). SREBP1a regulates transcription of HMG-CoA reductase via binding to the sterol response element (SRE) in the promoter region. HMG-CoA reductase is the rate-limiting enzyme in cholesterol biosynthesis. The interaction between SREBP1a and HIF-1suggests that HIF-1 may

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38

Patel, Dilipkumar. "Cholesterol metabolism in monocyte-derived macrophages." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46492.

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39

Cowan, Graeme James Macfarlane. "Studies of the cholesterol-dependent cytolysins." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486876.

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The cholesterol-dependent cytoiysins (COGs) are a group of toxins produced by several genera of Gram-positive bacteria, that bind to and form large oligomeric pores in target cell membranes that contain cholesterol. In addition to cell lysis, a great number of other biological functions have been described for many members of the group, including induction of cytokine release and complement activation. Some of the COGs have been shown to be critical virulence factors of their producing organisms and immunisation with a number of the COCs has been shown to be protective against disease caused b

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40

Sather, Paula Joan. "Synthesis of cholesterol based model glycolipids." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29876.

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The synthesis of glycolipids containing a variable length polyethylene glycol spacer group between a glucuronic acid (glu) headgroup and a cholesterol (chol) tail glu-0CH₂(CH₂OCH₂ )nCH₂O-chol is described. The homologs (n=2,3,5) were prepared by reaction of an excess of commercially available tri, tetra and hexaethylene glycols with cholesteryl-p-toluene sulfonate. 3-O-(8-hydroxy-3,6-dioxaoctyl) cholest-5-ene (2), 3-O-(ll-hydroxy-3,6,9-trioxaundecyl)cholest-5-ene (3) and 3-O-(17-hydroxy-3,6,9,12,15-pentaoxaheptadecyl)cholest-5-ene (4) were produced, and yields were dependent on the amount of

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41

Garofalo, Flavio A. (Flavio Alberto). "Removal of cholesterol by Pseudomonas pictorum." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63857.

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42

Corvera, Poiré Eugenia. "Permeability of lipid bilayers containing cholesterol." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60030.

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Lipid-cholesterol bilayers are studied by means of a microscopic multi-state lattice model and Monte Carlo computer simulations. The model used is a direct extension of the Pink model for the main transition of pure lipid bilayers. Cholesterol is introduced as a bulky, rigid molecule with no internal degrees of freedom. The model is able to account for the chain melting of lipid molecules, and is expected to be valid at low cholesterol concentrations.<br>A minimal model for the transport of ions across membranes is used to predict the changes in the passive permeability of lipid-cholesterol bi

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43

Hoang, Van Quyen. "Cholesterol metabolism in cultured hamster hepatocytes." Thesis, Royal Veterinary College (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522583.

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44

Banerjee, Subhashis. "INHIBITION OF CHOLESTEROL SYNTHESIS BY POLICOSANOL." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/4.

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Cholesterol is an essential component of the cell, but excessive blood levels are a major risk factor for the development of atherosclerotic plaques that can lead to heart disease and stroke, the foremost cause of premature death in Western societies. Policosanol, a mixture of very long chain alcohols derived from sugarcane, has gained considerable attention among the public as safe and effective means to reduce blood cholesterol levels, a belief based on some early clinical studies. My research investigates one possible mechanism by which policosanol might decrease blood cholesterol levels: t

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45

曾紹怡 and Siu-yee Patricia Tsang. "Regulation of cholesterol metabolism in hepatocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31969835.

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46

Donckers-Roseveare, Kathryn. "Periodic feedback to reduce cholesterol levels." Thesis, Virginia Tech, 1990. http://hdl.handle.net/10919/41912.

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47

Simonen, Piia. "Cholesterol metabolism in type 2 diabetes." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/simonen/.

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48

Tsang, Siu-yee Patricia. "Regulation of cholesterol metabolism in hepatocytes." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22032459.

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49

Boone, Lindsey R. "Thyroid Hormone Regulation of Cholesterol Metabolism." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0003089.

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50

Sampson, William James. "The intracellular control of cholesterol metabolism." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/26913.

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The liver has a major role in the metabolism of cholesterol, being the main site of lipoprotein assembly and degradation and the only tissue where the metabolism of cholesterol to bile acids occurs. This provides the major pathway for the removal of cholesterol from the body. The results described in this thesis concern the use of specific enzyme inhibitors (58-035, Azacholesterol, Mevinolin) to determine the intracellular use of different sources of cholesterol in monolayers of rat hepatocytes. In particular, the fates of newly synthesized cholesterol from mevalonic acid and cholesterol deriv

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