Relevant bibliographies by topics / Cholinergic toxidrome

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Academic literature on the topic 'Cholinergic toxidrome'

Author: Grafiati
Published: 24 April 2022
Last updated: 30 July 2025

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Journal articles on the topic "Cholinergic toxidrome"

1

Krishna, M. Ravi, and N. Sneha. "Tracheal gas insufflation for refractory hypercapnia." Journal of Mechanical Ventilation 5, no. 3 (2024): 109–13. http://dx.doi.org/10.53097/jmv.10108.

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A 65 year male patient got admitted to ICU after alleged intake of ~ 250 ml of Chlorpyrifos (Organophosphate insecticides which cause cholinergic toxidrome) and cypermethrin (Synthetic pyrethroid) and presented with cholinergic toxidrome with severe hypercapnia (supercarbia). All conventional and advanced modes of ventilation failed to ventilate the patient because of severe bronchospasm and a prolonged expiratory time constant with high airway pressures and high auto-peep. As a last resort, we resorted to unconventional modes, as the patient could not afford ECMO. Tracheal gas insufflation wa
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Krishna, M. Ravi, and N. Sneha. "Tracheal gas insufflation for refractory hypercapnia." Journal of Mechanical Ventilation 5, no. 3 (2024): 109–13. https://doi.org/10.53097/JMV.10108.

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Abstract A 65-year male patient got admitted to ICU after alleged intake of ~ 250 ml of Chlorpyrifos (Organophosphate insecticides which cause cholinergic toxidrome) and cypermethrin (Synthetic pyrethroid) and presented with cholinergic toxidrome with severe hypercapnia (supercarbia). All conventional and advanced modes of ventilation failed to ventilate the patient because of severe bronchospasm and a prolonged expiratory time constant with high airway pressures and high auto-peep. As a last resort, we resorted to unconventional modes, as the patient could not afford ECMO. Tracheal gas insuff
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3

Kravets, O. V., V. V. Yekhalov, V. A. Sedinkin, O. V. Pylypenko, and D. A. Martynenko. "Anticholinergic syndrome in the perioperative period (review). Part 1." EMERGENCY MEDICINE 21, no. 4 (2025): 414–19. https://doi.org/10.22141/2224-0586.21.4.2025.1890.

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Anticholinergic syndrome is a febrile toxidrome characterized by the suppression of cholinergic neurotransmission in muscarinic receptors. A prerequisite for its development is that pharmacological agents must be lipophilic and capable of crossing the blood-brain barrier to block muscarinic cholinergic receptors. Triggers of anticholinergic toxidrome include alkaloids from over 2,000 species of plants and fungi, antipsychotics, antidepressants, antiparkinsonian drugs, antispasmodics, ocular and antihistamine medications, general and local anesthetics, which are often prescribed in combinations
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Marshall, Katherine, Kathy Fritz, Wayne Thom, and Glen L. Xiong. "Toxic Interaction Between Fluoxetine And Donepezil: A Case Of Cholinergic Toxidrome." Journal of Neuropsychiatry and Clinical Neurosciences 24, no. 2 (2012): E50. http://dx.doi.org/10.1176/appi.neuropsych.11060133.

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Villa, Antonio. "Acute aldicarb (Chumbinho) poisoning in a young Brazilian woman: A case report." Advances in Medicine, Psychology, and Public Health 2, no. 1 (2024): 72–75. https://doi.org/10.5281/zenodo.12507853.

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Al-Shalchi, R. F., and F. K. Mohammad. "Changes in propofol anaesthesia and dichlorvos toxicity in mice following repeated dosing with three hypolipidemic statins." BULGARIAN JOURNAL OF VETERINARY MEDICINE 28, no. 2 (2025): 267–77. https://doi.org/10.15547/bjvm.2024-0002.

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Undesirable effects of hypolipidemic statins in rodents are characterised by neurobehavioural alterations with changes in the cholinergic/cholinesterase and neurotropic systems. The purpose of the study was to administer repeatedly three different statins: atorvastatin, simvastatin and rosuvastatin, in male Swiss mice and explore their behavioural outcomes after challenging them with the anaesthetic propofol and the cholinesterase inhibitor dichlorvos. A total of 92 mice were randomly allocated to each statin (200 mg/kg/day) or distilled water-control (10 mL/kg/day) treatment groups (n= 8 or 1
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Wojtyła-Buciora, Paulina, Teresa Grzelak, Wojciech Giermaziak, Rafał Mikołajczak, Lucyna Kapka-Skrzypczak, and Edyta Mądry. "Novel Psychoactive Substances as a Vital and Ever-Changing Concern in Public Health." Biuletyn Głównej Biblioteki Lekarskiej 56, no. 381 (2023): 97–106. https://doi.org/10.2478/bgbl-2023-0016.

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Summary New/novel psychoactive substances (NPS) are substances of varying chemical structures and, in their physical forms, are taken and ingested and exhibit many diverse drug interactions. They are used in pure form and/or as mixtures of psychoactive substances, also often combined with other drugs or ethyl alcohol, which can change how receptors function, whether they be adrenergic, serotonergic, or dopaminergic, opioid and/or cannabinoid. Identifying NPS users is difficult because of the constantly changing range of new drugs available, which poses analytical challenges in finding sufficie
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Rafiqul Islam, Mohammad, Sarmistha Biswas, Syed Zakir Hossain, Nafizul Islam, Gourab Dewan, and Mohammad Robed Amin. "Pattern and risk factors of acute poisoning in a tertiary hospital of Central Bangladesh." Journal of Emergency Practice and Trauma 5, no. 1 (2018): 23–28. http://dx.doi.org/10.15171/jept.2018.11.

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Objective: Acute poisoning is a common cause of hospital admission in Bangladesh. But, risk factors and characteristics of victims of different modes of poisoning have not been evaluated for possible intervention strategies. So, in this study we aimed to describe the pattern of acute poisoning in central Bangladesh as well as identifying risk factors for various mode of poisoning. Methods: A prospective observational study was undertaken in Dhaka Medical College Hospital in 2015. Consenting adult acute poisoning victims were included as study subjects. A pretested structured case record form w
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Amin, Md Robed. "Basic approach to poisoning focusing “Toxidrome”." Bangladesh Journal of Medicine, May 24, 2023, 185–86. http://dx.doi.org/10.3329/bjm.v34i20.66125.

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Background: The term “toxidrome” is derived from the term “toxic syndrome.”A toxidrome is a constellation of signs and symptoms that are seen with particular classes of poisons. Methods: A systematic review of English literature was done with search item naming toxidrome and or basic approach to poisoning. Search engine was multiple leaded by pubmed having mesh term of toxidrome. The journal sites of asiajol and banglajol was also searched for related topics. Personal communication with toxicology related paper was also applied during the process. Results: All of the toxidromes can be identifi
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Hoffman, Robert J., and Andrea Nillas. "Toxidromes and a general approach to poisoning." Archives of Disease in Childhood, February 20, 2025, archdischild—2024–326969. https://doi.org/10.1136/archdischild-2024-326969.

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A toxicologic syndrome, or toxidrome, is a distinct pattern of effects of poisoning. Well-defined toxidromes are the opioid, anticholinergic, cholinergic and sympathomimetic, and an additional described toxidrome is GABAergic. These toxidromes are named for the receptor effects causing their specific clinical findings, and knowledge of toxidromes allows rapid pattern recognition of specific poisonings. In this review, toxidromes and the initial assessment and general approach to management of acute poisoning are discussed. This article details the receptor-level effects of the poisoning, key c
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Book chapters on the topic "Cholinergic toxidrome"

1

Dorsett, Maia. "Vomiting." In Acute Care Casebook, edited by Jeremy T. Cushman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190865412.003.0011.

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This case illustrates the priorities of management in a patient with acute organophosphate toxicity in the prehospital environment. Organophosphates are common components of pesticides. They act as toxins and can lead to development of the cholinergic toxidrome by blocking breakdown of the neurotransmitter acetylcholine at nerve endings. The cholinergic toxidrome is a clinical syndrome marked by parasympathetic excess (bradycardia, bronchorrhea, bronchospasm, miosis, lacrimation, salivation, urination, and defecation), neuromuscular junction activation (muscle fasciculations), and central nerv
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Espinoza, Luis, and Joshua da Silva. "Acetylcholine Overload: Organophosphate and Carbamate Exposures." In Medical Toxicology. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780197635513.003.0031.

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Abstract Pesticides and insecticides containing organophosphates cause roughly 3 million poisonings and approximately 250,000 deaths worldwide every year. When exposed, these agents block acetylcholinesterase from breaking down acetylcholine, leading to a dangerous buildup of acetylcholine in the neuronal spaces. This accumulation continually stimulates postsynaptic nicotinic and muscarinic receptors, leading to a cholinergic toxidrome characterized by excess hyperstimulation of secretions and respiratory paralysis, as well as a host of other symptoms. If untreated, exposure can lead to coma a
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Horoszczak, Cassian, and Stacey Watt. "Chemical and Biological Warfare." In Advanced Anesthesia Review, edited by Alaa Abd-Elsayed. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/med/9780197584521.003.0341.

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Abstract Chemical and biological warfare agents pose as major health threats in not only modern warfare, but also their potential use in domestic terrorism. Chemical warfare agents can be categorized into toxic agents (which includes nerve agents and cyanide salts), incapacitating agents, and incendiary/burn-causing agents. Nerve agents function as anticholinesterase inhibitors, causing a cholinergic toxidrome, which is treated with atropine and pralidoxime following exposure. Cyanide inactivates cytochrome oxidase, resulting in cellular anoxia and is treated with a first-line combination of s
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Garcia, Samuel, and Aaron Skolnik. "Hot as a hare: Critically ill toxidromes." In Critical Care Emergencies, edited by Lillian Liang Emlet. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/med/9780190082581.003.0035.

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Abstract This chapter summarizes critical toxidromes that are commonly encountered in the emergency department and provides an in-depth review of anticholinergic poisoning. It describes the classic presentation for five common toxidromes: opioid, sedative–hypnotic, sympathomimetic, cholinergic, and anticholinergic. A case is presented of a patient with a known overdose of an anticholinergic drug who arrives to the emergency department in extremis: She is tachycardic, hypertensive, hyperthermic, and anhidrotic and has altered mentation. The presentation, diagnosis, treatment, and disposition of
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Aki, Ehab, Mohammed Abdurabu, and Mohamed Elgassim. "Toxicology in Emergency Medicine." In Poisoning - New Insights [Working Title]. IntechOpen, 2025. https://doi.org/10.5772/intechopen.1010983.

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Toxicology is a critical component of emergency medicine, requiring rapid assessment and management to prevent morbidity and mortality. This chapter provides a structured approach to poisoned patients, beginning with initial stabilization using airway, breathing, and circulation (ABCs) and a focused history, including the AMPLE mnemonic (Allergies, Medications, Past medical history, Last meal, Events leading to presentation). A key focus is on toxidromes—distinctive clinical syndromes that offer diagnostic clues for poisoning—including cholinergic, anticholinergic, opioid, sympathomimetic, and
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