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Relevant bibliographies by topics / Chondrosarcoma Immunohistochemistry Notch receptors Notch ligands cells

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Academic literature on the topic 'Chondrosarcoma Immunohistochemistry Notch receptors Notch ligands cells'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Chondrosarcoma Immunohistochemistry Notch receptors Notch ligands cells"

1

Filipović, M., A. Šućur, D. Flegar, et al. "FRI0372 INCREASED EXPRESSION OF NOTCH RECEPTORS ON OSTEOCLAST PROGENITORS INDUCED BY RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 783.1–783. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1693.

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Background:Systemic and periarticular bone loss in rheumatoid arthritis (RA) is mediated by osteoclasts, multinucleated cells originating from the myeloid lineage. Recently, Notch signaling pathway has emerged as a potential regulator of osteoclast progenitor (OCP) differentiation and activation.Objectives:The exact role of Notch signaling in the context of arthritis is still unknown; however, its inhibition has beneficial effects in animal arthritis models. We aimed to determine the expression of Notch receptors and ligands on specific OCP subpopulations and define changes that occur in murin

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Luo, B., J. C. Aster, R. P. Hasserjian, F. Kuo, and J. Sklar. "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor." Molecular and Cellular Biology 17, no. 10 (1997): 6057–67. http://dx.doi.org/10.1128/mcb.17.10.6057.

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Signaling through Notch receptors has been implicated in the control of cellular differentiation in animals ranging from nematodes to humans. Starting from a human expressed sequence tag-containing sequence resembling that of Serrate, the gene for a ligand of Drosophila melanogaster Notch, we assembled a full-length cDNA, now called human Jagged2, from overlapping cDNA clones. The full-length cDNA encodes a polypeptide having extensive sequence homology to Serrate (40.6% identity and 58.7% similarity) and even greater homology to several putative mammalian Notch ligands that have subsequently

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Kim, Jin-A., Young-Ju Kang, Kyung-Sin Park, Eek-Hoon Jho, and Il-Hoan Oh. "Microenvironmental Cross-Talk of Wnt/Notch Signal in Hematopoietic Stem Cell." Blood 112, no. 11 (2008): 3569. http://dx.doi.org/10.1182/blood.v112.11.3569.3569.

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Abstract Microenvironment in the stem cell niche plays an important role to regulate self-renewal and differentiation of hematopoietic stem cells (HSCs). We previously showed opposing effects of b-catenin activation on HSC depending on target of activation in the bone marrow microenvironment. To further analyze the microenvironmental regulation of HSC by Wnt/b-catenin signal, we examined b-catenin activation mode in the trabecular bone marrows. In-situ immunohistochemistry of bone marrows revealed a compartmentalized enrichment of b-catenin in the spindle shaped, CD45(−) endosteal stroma of bo

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Alexander, Katherine A., Jason W. Eng, Yu Kato, et al. "Abstract 1610: Notch4 plays distinct roles in different cell types of the breast cancer microenvironment." Cancer Research 85, no. 8_Supplement_1 (2025): 1610. https://doi.org/10.1158/1538-7445.am2025-1610.

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Abstract The Notch developmental pathway regulates cell fate in tumor angiogenesis and influences immune cell phenotypes in the tumor microenvironment (TME). While Notch receptors Notch1-3 have been extensively studied, the role of Notch4 in the tumor microenvironment is poorly understood. Previous efforts to target Notch signaling and tumor angiogenesis have been limited by broad expression of Notch receptors and their cognate ligands, leading to significant gastrointestinal toxicity. However, Notch4 is thought to be expressed primarily in the endothelium, making it a highly specific and, the

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Chen, Junyi, and Jiahui Fang. "Abstract 4628: Exploring the differences in immunotherapy efficacy and immune microenvironment characteristics among colorectal cancer patients with different notch receptor gene subtypes." Cancer Research 85, no. 8_Supplement_1 (2025): 4628. https://doi.org/10.1158/1538-7445.am2025-4628.

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Abstract Background: The NOTCH signaling pathway is a highly conserved signaling system regulated by close-range cell-to-cell interactions. The interaction between NOTCH receptors (NOTCH1-4) and "classical" ligands, or the activation of other non-classical pathways, is associated with the occurrence and progression of various tumors. Although some studies have confirmed a correlation between the efficacy of immunotherapy and NOTCH gene mutations, no definitive conclusion has been reached in colorectal cancer. Exploring the tumor immune microenvironment may help us find better answers. Methods:

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Guillaumet-Adkins, Amy, Praveen Anand, Huiyoung Yun, et al. "Single Cell RNA-Seq Reveals Deranged Developmental Hierarchy with Coexisting Oncogenic States and Immune Evasion Programs in ETP T-ALL." Blood 134, Supplement_1 (2019): 3953. http://dx.doi.org/10.1182/blood-2019-130482.

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Introduction: Early T-cell precursor acute lymphoblastic leukemia (ETP T-ALL) is a distinct subtype of T-ALL characterized by higher rates of relapse and induction failure. Large-scale genetic sequencing studies have identified frequently mutated oncogenes and gene fusions in ETP T-ALL, while bulk transcriptome analyses have revealed expression features resembling myeloid precursors and myeloid malignancies. However, the contributions of intra-tumoral functional heterogeneity and microenvironment to tumor biology and treatment failure remain unknown. Methods: We performed full-length single-ce

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Medina, Vanessa, Guadalupe Aparicio Gallego, Isabel Santamarina, Manuel Valladares Ayerbes, and Luis M. Antón Aparicio. "Biomolecular characterization of formalin-fixed paraffin-embedded primary renal tumor specimens." Journal of Clinical Oncology 30, no. 5_suppl (2012): 421. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.421.

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421 Background: Renal cell carcinoma (RCC) is the most common type of kidney cancer. It is required a better understanding of signalling pathways involved in renal cells. Methods: We assessed using immunohistochemistry (IHC) and quantitative real-time PCR (qPCR) with SYBR Green the profile of predictive markers involved in the cascade of events leading to the formation and progression: invasiveness, angiogenesis and antiapoptotic mechanisms. 80 RCC tissues were detected by IHC. RNA of quality only was obtained in 72 (80% clear RCC, 10% papillary RCC and 10% chromophobe RCC) to carry out the st

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Härzschel, Andrea, Peter William Krenn, Elisabeth Bayer, et al. "The Integrin Adaptor Kindlin-3 Is Important for Development and Retention of Marginal Zone B Cells." Blood 136, Supplement 1 (2020): 46–47. http://dx.doi.org/10.1182/blood-2020-136905.

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Introduction The development and maturation of B cells is highly dependent on signals provided by the microenvironment of the lymphatic organs. As B cells move from one developmental stage and niche to the next, the integrin family of adhesion molecules provides important cues for their correct positioning and retention. The integrin adaptor protein Kindlin-3 (encoded by the Fermt3 gene) regulates integrin activity and function in a wide range of hematopoietic cell types. In this study, we aimed to define its precise role in the development and function of the different murine B cell subsets.

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Siar, C. H., K. O. Ha, L. O. Aung, et al. "IMMUNOLOCALIZATION OF NOTCH SIGNALING PROTEIN MOLECULES IN A MAXILLARY CHONDROSARCOMA AND ITS RECURRENT TUMOR." June 19, 2017. https://doi.org/10.5281/zenodo.811988.

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Background: Notch receptors are critical determinants of cell fate in a variety of organisms. Notch signaling is involved in the chondrogenic specification of neural crest cells. Aberrant Notch activity has been implicated in numerous human diseases including cancers; however its role in chondrogenic tumors has not been clarified. Method: Tissue samples from a case of primary chondrosarcoma of the maxilla and its recurrent tumor were examined immunohistochemically for Notch1-4 and their ligands (Jagged1, Jagged2 and Delta1) expression. Results: Both primary and recurrent tumors were histopatho

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Siar, C. H., K. Nakano, K. H. Ng, M. Tomida, H. Nagatsuka, and T. Kawakami. "Squamous odontogenic tumor of the mandible: A case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1." June 19, 2017. https://doi.org/10.5281/zenodo.811996.

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Background: Squamous odontogenic tumor (SOT) is a rare benign odontogenic epithelial neoplasm. A slow-growing painless expansive swelling is the common presenting symptom. Histopathologically, SOT can be easily misdiagnosed as an acanthomatous ameloblastoma. Although Notch receptors and ligands have been shown to play a role in cell fate decisions in ameloblastomas, the role of these cell signaling molecules in SOT is unknown. Case report: This paper describes a case of SOT affecting the anterior mandible of a 10-year-old Indian female. The patient was treated by local surgical excision and th

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