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Journal articles on the topic 'Chorée de Huntington'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 August 2024

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1

Chesselet, MF. "La chorée de Huntington." médecine/sciences 4, no. 8 (1988): 492. http://dx.doi.org/10.4267/10608/3868.

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2

Peschanski, M. "Du nouveau sur la chorée de Huntington." médecine/sciences 12, no. 4 (1996): 535. http://dx.doi.org/10.4267/10608/778.

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3

Lucotte, G. "Diagnostic prénatal de la chorée de Huntington." Journal de Pédiatrie et de Puériculture 5, no. 3 (1992): 150–52. http://dx.doi.org/10.1016/s0987-7983(05)80302-0.

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4

Liévens, Jean-Charles, and Serge Birman. "Les astrocytes dans la chorée de Huntington." médecine/sciences 23, no. 10 (2007): 845–49. http://dx.doi.org/10.1051/medsci/20072310845.

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5

Lucotte, G. "Mais où est donc passé le gène de la chorée de Huntington ?" médecine/sciences 7, no. 10 (1991): 1071. http://dx.doi.org/10.4267/10608/4508.

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6

Alex Parker, J., Margarita Arango, Salima Abderrahmane, et al. "Neuroprotection par l’activation des sirtuines dans des modèles simplifiés de chorée de Huntington." médecine/sciences 21, no. 5 (2005): 556–57. http://dx.doi.org/10.1051/medsci/2005215556.

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7

Lucotte, G. "Répétitions trinucléotidiques CAG dans les cas de chorée de Huntington : une vaste enquête mondiale." médecine/sciences 10, no. 11 (1994): 1168. http://dx.doi.org/10.4267/10608/2548.

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8

Dodé, C. "Dernière heure : le gène de la chorée de Huntington, la fin d'une longue traque." médecine/sciences 9, no. 4 (1993): 488. http://dx.doi.org/10.4267/10608/2951.

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9

Liévens, Jean-Charles, and Serge Birman. "La chorée de Huntington chez la drosophile et chez la souris : vers de nouvelles pistes thérapeutiques ?" médecine/sciences 19, no. 5 (2003): 593–99. http://dx.doi.org/10.1051/medsci/2003195593.

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10

Grandmougin, T., C. Bourdet, and JM Gurruchaga. "De la danse de Saint-Guy à la chorée de Huntington : rappels sur l'émergence d'un concept médical." médecine/sciences 13, no. 6-7 (1997): 850. http://dx.doi.org/10.4267/10608/471.

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11

Labrune, P. "Diagnostic génétique pré-implantatoire de la chorée de Huntington sans savoir si le parent « à risque » est atteint." Archives de Pédiatrie 10, no. 2 (2003): 170. http://dx.doi.org/10.1016/s0929-693x(03)00319-1.

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12

Sari, Youssef. "Huntington’s Disease: From Mutant Huntingtin Protein to Neurotrophic Factor Therapy." International Journal of Biomedical Science 7, no. 2 (2011): 89–100. http://dx.doi.org/10.59566/ijbs.2011.7089.

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Huntington's disease (HD) is an inherited disorder characterized by neuronal dysfunction and degeneration in striatum and cerebral cortex. Although the signaling pathways involved in HD are not yet clearly elucidated, mutant huntingtin protein is a key factor in the induction of neurodegeneration. The mutant huntingtin protein alters intracellular Ca2+ homeostasis, disrupts intracellular trafficking and impairs gene transcription. In this review, I emphasize the effects of mutant huntingtin protein in Ca2+ handling and transcriptional factors. Transcriptional alterations are key factors in the
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13

Forbes, James. "“A Deplorable Speech”: The Liberal Party vs. Anti-Catholicism during the Alexander Mackenzie Administration, 1873–1878." Journal of the Canadian Historical Association 28, no. 1 (2018): 193–216. http://dx.doi.org/10.7202/1050899ar.

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After decades of raising the “no popery” cry and fighting for the strict separation of church and state, Canada’s Liberal Party leaders began in the 1870s to distance themselves from their previous reputation for anti-Catholicism and from their hardline approach to church-state policy. This article examines the Alexander Mackenzie administration’s response to the Argenteuil Speech of 1875, in which Liberal cabinet minister Lucius Huntington called for all Protestants to unite with liberal Catholics to challenge the Roman Catholic Church’s rising political influence in Canada. Although several
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14

Quintanas, Anna. "Una crítica político-antropológica al «choque de civilizaciones» de Samuel P. Huntington." Isegoría, no. 26 (June 30, 2002): 239–50. http://dx.doi.org/10.3989/isegoria.2002.i26.577.

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15

Molina Santamaria, Ximena, and Tatiana Paola Bautista Safar. "Del Choque de Civilizaciones al choque con la realidad: Samuel Huntington 20 años después." El Ágora USB 19, no. 1 (2019): 220–30. http://dx.doi.org/10.21500/16578031.3392.

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Samuel Huntington plantea en 1996 las líneas de fractura en su obra Choque de civilizaciones, como guía para entender los conflictos mundiales. Veinte años después de su lanzamiento, se pretende determinar si las hipótesis del autor son vigentes para el caso de Crimea en el contexto actual. El documento hará un acercamiento a la teoría planteada por Huntington, profundizando en las críticas hechas a los postulados para analizar su vigencia, en el caso ucraniano.
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16

Estrada-Sánchez, Ana María, Courtney L. Blake, Scott J. Barton, Andrew G. Howe, and George V. Rebec. "Lack of mutant huntingtin in cortical efferents improves behavioral inflexibility and corticostriatal dynamics in Huntington’s disease mice." Journal of Neurophysiology 122, no. 6 (2019): 2621–29. http://dx.doi.org/10.1152/jn.00777.2018.

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Abnormal communication between cerebral cortex and striatum plays a major role in the motor symptoms of Huntington’s disease (HD), a neurodegenerative disorder caused by a mutation of the huntingtin gene ( mHTT). Because cortex is the main driver of striatal processing, we recorded local field potential (LFP) activity simultaneously in primary motor cortex (M1) and dorsal striatum (DS) in BACHD mice, a full-length HD gene model, and in a conditional BACHD/Emx-1 Cre (BE) model in which mHTT is suppressed in cortical efferents, while mice freely explored a plus-shaped maze beginning at 20 wk of
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17

Urrutia León, Manuel María. "¿Hacia una civilización universal? Una crítica del «choque de civilizaciones» de Huntington." Estudios de Deusto 56, no. 2 (2012): 105. http://dx.doi.org/10.18543/ed-56(2)-2008pp105-133.

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Desde su aparición en 1993, la teoría del «choque de civilizaciones » del politólogo Samuel P. Huntington se ha convertido en una de las más divulgadas y debatidas. En este artículo, tras una minuciosa lectura del libro de Huntington, se realiza una serie de críticas fundamentales a su paradigma para la política global: su concepción cerrada de las civilizaciones, su visión negativa de la diversidad cultural, su relativismo cultural, etc. Para concluir defendiendo un paradigma alternativo para las relaciones internacionales: el de un diálogo intercultural basado en el núcleo universalista de l
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18

Arriaga Martínez, Rafael. "Yihad, islam e inmigración: ¿Choque de civilizaciones o guerra de dioses?" Revista Temas Sociológicos, no. 19 (October 26, 2016): 201. http://dx.doi.org/10.29344/07194145.19.267.

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ResumenEn este trabajo consideramos la experiencia de los franceses de culturamusulmana a partir de dos visiones teóricas presentes implícitamenteen el debate de la inmigración. La primera, asociada estrechamente a lafigura de Samuel Huntington, quien postula como irremediable el conflictoentre las culturas y, en consecuencia, la dificultad de integración de losinmigrantes en las sociedades receptoras. La segunda, defendida en el marcodel multiculturalismo y otras corrientes de pensamiento, sostiene por elcontrario la posibilidad del diálogo, el entendimiento entre los individuoscon culturas d
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Arriaga Martínez, Rafael. "Yihad, islam e inmigración: ¿Choque de civilizaciones o guerra de dioses?" Revista Temas Sociológicos, no. 19 (October 26, 2016): 201. http://dx.doi.org/10.29344/07196458.19.267.

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ResumenEn este trabajo consideramos la experiencia de los franceses de culturamusulmana a partir de dos visiones teóricas presentes implícitamenteen el debate de la inmigración. La primera, asociada estrechamente a lafigura de Samuel Huntington, quien postula como irremediable el conflictoentre las culturas y, en consecuencia, la dificultad de integración de losinmigrantes en las sociedades receptoras. La segunda, defendida en el marcodel multiculturalismo y otras corrientes de pensamiento, sostiene por elcontrario la posibilidad del diálogo, el entendimiento entre los individuoscon culturas d
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20

Necpál, Ján, and Michal Patarák. "Hereditary chorea with a tendency to insanity and adult onset: 150 years since George Huntington and his disease." Neurologie pro praxi 23, no. 1 (2022): 93–96. http://dx.doi.org/10.36290/neu.2022.015.

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21

Nittari, Giulio, Proshanta Roy, Ilenia Martinelli, et al. "Rodent Models of Huntington’s Disease: An Overview." Biomedicines 11, no. 12 (2023): 3331. http://dx.doi.org/10.3390/biomedicines11123331.

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Huntington’s disease (HD) is an autosomal-dominant inherited neurological disorder caused by a genetic mutation in the IT15 gene. This neurodegenerative disorder is caused by a polyglutamine repeat expansion mutation in the widely expressed huntingtin (HTT) protein. HD is characterized by the degeneration of basal ganglia neurons and progressive cell death in intrinsic neurons of the striatum, accompanied by dementia and involuntary abnormal choreiform movements. Animal models have been extensively studied and have proven to be extremely valuable for therapeutic target evaluations. They reveal
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22

Zimmer, Luís Gustavo, and Guilherme Cardoso Estevão. "Pentecostalismo e o choque de civilizações: o Brasil e a identidade judaico-cristã." Sacrilegens 18, no. 1 (2021): 83–98. http://dx.doi.org/10.34019/2237-6151.2021.v18.34140.

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O presente artigo propõe discutir, por meio de perspectivas das Relações Internacionais, a relação entre o choque de civilizações e o pentecostalismo brasileiro. Nosso intuito aqui não é declarar apoio ou discordar da polêmica tese de Huntington, mas sim averiguar um apelo à identidade civilizacional neste grupo. Para tanto, buscaremos analisar a construção da identidade judaico-cristã fomentada pelos discursos de políticos e pastores pentecostais, bem como as implicações para esse “Outro” islâmico que surge nestes discursos. A religião é parte importante dessa lógica, ao originar civilizações
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23

Minati, Ludovico, Sylvie Piacentini, Francesca Ferrè, et al. "Choice-option evaluation is preserved in early Huntington and Parkinson’s disease." NeuroReport 22, no. 15 (2011): 753–57. http://dx.doi.org/10.1097/wnr.0b013e32834acb6e.

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24

Monclús, Antonio. "Una alternativa al choque de civilizaciones: el modelo educativo y cultural de Paulo Freire." Revista Iberoamericana de Educación 50 (May 1, 2009): 155–72. http://dx.doi.org/10.35362/rie500667.

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En su célebre libro sobre el choque de civilizaciones la teoría de Huntington se refiere no solo a la lucha de civilizaciones, que tienen líneas divisorias religiosas y no políticas, sino, además, a la reconstrucción, al reordenamiento, del orden mundial. Esta polémica sobre el choque de civilizaciones y culturas, aireada, aunque no originada en Huntington, se engarza con otra que, desde los años ochenta y a partir de la crisis suscitada en la unesco durante el último periodo del educador musulmán de origen senegalés Amadou-Mahtar M’Bow como director general, sigue vigente en torno a los model
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25

Hewitt, Samuel RC, Alice J. White, Sarah L. Mason, and Roger A. Barker. "Metacognitive insight into cognitive performance in Huntington’s disease gene carriers." BMJ Neurology Open 4, no. 1 (2022): e000268. http://dx.doi.org/10.1136/bmjno-2022-000268.

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ObjectivesInsight is an important predictor of quality of life in Huntington’s disease and other neurodegenerative conditions. However, estimating insight with traditional methods such as questionnaires is challenging and subjected to limitations. This cross-sectional study experimentally quantified metacognitive insight into cognitive performance in Huntington’s disease gene carriers.MethodsWe dissociated perceptual decision-making performance and metacognitive insight into performance in healthy controls (n=29), premanifest (n=19) and early-manifest (n=10) Huntington’s disease gene carriers.
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26

Venkatramaniah, C., and A. Mary Antony Praba. "A STUDY ON THE BEHAVIOUR OF HUNTINGTON’S CHOREA RAT MODELS ON ROTAROD: TREATED WITH WITHANOLIDE A AND THE ETHANOLIC EXTRACT OF WITHANIA SOMNIFERA." International Journal of Anatomy and Research 3, no. 4 (2015): 1510–14. http://dx.doi.org/10.16965/ijar.2015.286.

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27

Anderson, Karen E., Shirley Eberly, Karen S. Marder, et al. "The choice not to undergo genetic testing for Huntington disease: Results from the PHAROS study." Clinical Genetics 96, no. 1 (2019): 28–34. http://dx.doi.org/10.1111/cge.13529.

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28

Nogueira dos Santos, Robson. "A EXPANSÃO DO MUNDO ISLÂMICO PARA EUROPA." Geographia Opportuno Tempore 3, no. 1 (2017): 135–48. http://dx.doi.org/10.5433/got.2017.v3.31898.

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O presente artigo tem por finalidade fazer uma análise da expansão do mundo islâmico principalmente em direção a Europa, buscando interpretar como ocorre o crescimento desta população dentro de países europeus, ao mesmo tempo em que se utiliza da perspectiva do “Choque de Civilizações”. O trabalho é fundamentado na Teoria do Choque de Civilizações de Samuel Huntington, publicado nos anos de 1990. Discutimos neste trabalho o expansionismo islâmico, que historicamente conquistou inúmeros territórios após seu surgimento no século VII, entrando em confrontação com outras civilizações. Dessa forma,
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29

De Matos, Givaldo Mauro, and Elaine De Oliveira Silva. "O DESAFIO DA UNIVERSALIZAÇÃO DOS DIREITOS HUMANOS FRENTE AO MULTICULTURALISMO." Revista Jurídica 20, no. 1 (2021): 121–40. http://dx.doi.org/10.37951/2236-5788.2020v20i1.p121-140.

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O trabalho tem por finalidade demonstrar os valores dos direitos humanos, pois, os valores são elementos de uma cultura ou civilização. É bem verdade que existem direitos humanos que são conceitos muito locais, a questão a ser discutida é sobre a sua universalização. Como ponto de partida apresentaremos duas teses importantes no âmbito dos direitos humanos, de um lado a tese do português Boaventura de Sousa Santos que trabalha uma relativização da importância da cultura, que devem ser julgadas a partir de critérios internos, de outro lado, o americano Samuel P. Huntington, com a teoria do “cho
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30

Vaportzis, E., N. Georgiou-Karistianis, A. Churchyard, and JC Stout. "J15 Dual task performance in Huntington's disease: comparing choice reaction time tasks." Journal of Neurology, Neurosurgery & Psychiatry 83, Suppl 1 (2012): A40.2—A40. http://dx.doi.org/10.1136/jnnp-2012-303524.125.

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31

LEONARD, WANTCHEKON. "The Paradox of “Warlord” Democracy: A Theoretical Investigation." American Political Science Review 98, no. 1 (2004): 17–33. http://dx.doi.org/10.1017/s0003055404000978.

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Political theorists from Machiavelli to Huntington have denied the possibility of popular government arising out of the chaos of civil war, instead prescribing an intermediate stage of one-man rule by a Prince, Leviathan, or a military dictator. Based on recent empirical evidence of post-civil war democratization in El Salvador, Mozambique, and elsewhere, I show that democracy can arise directly from anarchy. Predatory warring factions choose the citizenry and democratic procedures over a Leviathan when (1) their economic interests depend on productive investment by the citizens, (2) citizens'
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32

van Wouwe, Nelleke C., Kristen E. Kanoff, Daniel O. Claassen, et al. "The Allure of High-Risk Rewards in Huntington’s disease." Journal of the International Neuropsychological Society 22, no. 4 (2015): 426–35. http://dx.doi.org/10.1017/s1355617715001241.

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AbstractObjectives: Huntington’s disease (HD) is a neurodegenerative disorder that produces a bias toward risky, reward-driven decisions in situations where the outcomes of decisions are uncertain and must be discovered. However, it is unclear whether HD patients show similar biases in decision-making when learning demands are minimized and prospective risks and outcomes are known explicitly. We investigated how risk decision-making strategies and adjustments are altered in HD patients when reward contingencies are explicit. Methods: HD (N=18) and healthy control (HC; N=17) participants comple
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33

Vaportzis, Eleftheria, Nellie Georgiou-Karistianis, Andrew Churchyard, and Julie C. Stout. "Dual task performance in Huntington’s disease: A comparison of choice reaction time tasks." Neuropsychology 29, no. 5 (2015): 703–12. http://dx.doi.org/10.1037/neu0000172.

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34

Popescu, Ionut. "Pragmatism and Practicality: Rethinking U.S. Civil–Military Relations Models for a Turbulent Era." Armed Forces & Society 45, no. 1 (2018): 198–205. http://dx.doi.org/10.1177/0095327x18765473.

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In his recent article Saving Samuel Huntington and the Need for Pragmatic Civil–Military Relations, Travis proposes a model of civil–military relations based on “pragmatic civilian control.” This model has three main shortcomings. First, it does not adequately answer the question of “professional supremacy” versus “civilian supremacy” in making crucial decisions during wartime. Second, the distinctions between “wars of choice” and “wars of necessity,” and about the “kind of war” being fought, key theoretical variables mentioned by the author, are hard to judge objectively. And third, the new m
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35

Jayshwal, Vijay Prasad, and Seema Kumari Shah. "Narratives of ‘Common Civilization’ of South Asia: Tracing the Origin of Shared Values and Culture." Dera Natung Government College Research Journal 8, no. 1 (2023): 155–68. http://dx.doi.org/10.56405/dngcrj.2023.08.01.11.

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South Asia is a constructed concept. Although South Asian countries choose to function within the paradigm of independent statehood, they are undergoing overlapping developments rooted in the distant and recent colonial past. This paper reflects on the notion that South Asia has a common past. In this context, the civilizational politics of India is addressed and the discourse on civilization is unwrapped to understand its contemporary and historical perspectives. The study of South Asian history constructs that Indus valley civilization presents a common ground for cultural and civilizational
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36

Adjeroud, Najia, Sara Yagüe, Libo Yu-Taeger, et al. "Reduced impact of emotion on choice behavior in presymptomatic BACHD rats, a transgenic rodent model for Huntington Disease." Neurobiology of Learning and Memory 125 (November 2015): 249–57. http://dx.doi.org/10.1016/j.nlm.2015.10.003.

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37

PIROGOVSKY, EVA, JODY GOLDSTEIN, GUERRY PEAVY, MARK W. JACOBSON, JODY COREY-BLOOM, and PAUL E. GILBERT. "Temporal order memory deficits prior to clinical diagnosis in Huntington’s disease." Journal of the International Neuropsychological Society 15, no. 5 (2009): 662–70. http://dx.doi.org/10.1017/s1355617709990427.

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AbstractThe current study examined temporal order memory in preclinical Huntington’s disease (pre-HD). Participants were separated into less than 5 years (pre-HD near) and more than 5 years (pre-HD far) from estimated age of clinical diagnosis. Participants completed a temporal order memory task on a computerized radial eight-arm maze. On the study phase of each trial, participants viewed a random sequence of circles appearing one at a time at the end of each arm. On the choice phase, participants viewed two circles at the end of the study phase arms and chose the circle occurring earliest in
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38

Trueman, R. C., S. B. Dunnett, L. Jones, and S. P. Brooks. "Five choice serial reaction time performance in the HdhQ92 mouse model of Huntington's disease." Brain Research Bulletin 88, no. 2-3 (2012): 163–70. http://dx.doi.org/10.1016/j.brainresbull.2011.10.019.

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39

Jansson, Erik Karl Håkan, Laura Emily Clemens, Olaf Riess, and Huu Phuc Nguyen. "Reduced Motivation in the BACHD Rat Model of Huntington Disease Is Dependent on the Choice of Food Deprivation Strategy." PLoS ONE 9, no. 8 (2014): e105662. http://dx.doi.org/10.1371/journal.pone.0105662.

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40

Taju, Atalia Eureka Putri, and Kholifatus Saadah. "Talking about Ideal Civil-Military Relationship: Comparation Cases between Military in Indonesia and India in Dealing with Covid-19 Pandemic." Journal of International Studies on Energy Affairs 2, no. 2 (2020): 165–78. http://dx.doi.org/10.51413/jisea.vol2.iss2.2021.165-178.

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The relationship between civil and military has many dimensions, and this relationship may be ideal. This article uses Huntington and Feaver's preferences to explain the ideal civil-military relationship in India and Indonesia through case studies of handling the COVID-19 pandemic. The choice of the two countries was due to Indonesia and India showing the dynamics of the relationship between civilians and the military from being quite harsh to be ideal. The ideal civil-military relationship can be described as a military subject to civilian control. However, this does not mean that the civilia
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Bedin, Gilmar Antonio, Elenise Felzke Schonardie, and Aline Michele Pedron Leves. "OS DIREITOS HUMANOS, A MULTICULTURALIDADE E O RISCO DO CHOQUE DE CIVILIZAÇÕES: UMA ANÁLISE DO MUNDO PÓS-GUERRA FRIA." Revista Direito em Debate 28, no. 52 (2019): 92–105. http://dx.doi.org/10.21527/2176-6622.2019.52.92-105.

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O presente tem como objetivo examinar, no mundo pós-guerra fria, a emergência da globalização e os riscos de choque de civilizações daí decorrentes. Partindo do pressuposto de que o direito e a história sempre estiveram algum nível de conexão, nota-se que as transformações do pós-segunda Guerra mundial e os processos decorrentes do fenômeno da globalização tornaram mais evidente esse processo e que, em consequência, potencializaram os riscos de conflitos de grande intensidade e violação dos direitos humanos. Nesse sentido, torna-se evidente o questionamento acerca de como é possível superar os
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42

Jahanshahi, M., R. G. Brown, and C. D. Marsden. "A comparative study of simple and choice reaction time in Parkinson's, Huntington's and cerebellar disease." Journal of Neurology, Neurosurgery & Psychiatry 56, no. 11 (1993): 1169–77. http://dx.doi.org/10.1136/jnnp.56.11.1169.

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43

Hill, Allen, and Julie Nantel. "Sensitivity of discrete symmetry metrics: Implications for metric choice." PLOS ONE 17, no. 5 (2022): e0268581. http://dx.doi.org/10.1371/journal.pone.0268581.

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Gait asymmetry is present in several pathological populations, including those with Parkinson’s disease, Huntington’s disease, and stroke survivors. Previous studies suggest that commonly used discrete symmetry metrics, which compare single bilateral variables, may not be equally sensitive to underlying effects of asymmetry, and the use of a metric with low sensitivity could result in unnecessarily low statistical power. The purpose of this study was to provide a comprehensive assessment of the sensitivity of commonly used discrete symmetry metrics to better inform design of future studies. Mo
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44

Rafael, Hernando, and María Teresa Valadez. "Hypothalamic Revascularization and Rejuvenation." Journal of Aging and Gerontology 2, no. 1 (2014): 24–29. http://dx.doi.org/10.12974/2309-6128.2014.02.01.4.

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Background: Since 1990 and to date, four therapeutic methods have been used against aging. All of them, to increase the plasma growth hormone levels. Material and Method: We choose 38 patients to analyse the postoperative rejuvenation. Previously, all of them have been received omental transplantation on the optic chiasma, the carotid bifurcation and the anterior perforated space. Patients with stroke in 14 cases, Alzheimer´s disease (AD) in 23 and Huntington´s disease (HD) in 1. The clinical data of rejuvenation were obtained by observation, videotape and photography. Results: Neurological im
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45

Atterton, Peter. "What It Means to Be an American Today: Democracy “To Come”." Culture and Dialogue 1, no. 2 (2013): 37–61. http://dx.doi.org/10.1163/24683949-00102003.

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This essay addresses the question of what it means to be an American today. In the first half, I respond to Samuel P. Huntington’s claim that America’s national identity is fundamentally Anglo-Protestant by rehearsing Jacques Derrida’s argument that the founding of a nation whose self-understanding is based on the idea of a social contract, such as the United States, implies an “originating violence” governed by extralegal considerations. In the second half, I discuss the “melting pot” and “salad bowl” concepts of American identity and show how deconstruction does not force us to choose betwee
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Daniels, Jo, Peter McGuffin, and Mike Owen. "Molecular genetic research on IQ: can it be done? Should it be done?" Journal of Biosocial Science 28, no. 4 (1996): 490–507. http://dx.doi.org/10.1017/s0021932000022550.

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An obvious requirement before embarking on molecular genetic investigation of a trait is prior evidence from ‘classic’ genetic studies that there is indeed a genetic component. Many behavioural traits are familial and these range from comparatively uncommon single gene disorders such as Huntington's disease which has a typical mendelian dominant pattern of transmission, to much commoner characteristics such as career choice or religious denomination which, it might be assumed, are heavily influenced by cultural factors. In between, there is a wide range of attributes including personality type
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Zhang, Jiqian, Wei Dai, Pengcheng Geng, et al. "Midazolam Enhances Mutant Huntingtin Protein Accumulation via Impairment of Autophagic Degradation In Vitro." Cellular Physiology and Biochemistry 48, no. 2 (2018): 683–91. http://dx.doi.org/10.1159/000491895.

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Background/Aims: Autophagy is a well-known pathway to “clean” the misfolded mutant huntingtin protein (mHtt), which plays a considerable role in polyglutamine diseases. To date, there have been few studies of the choice of anesthetic during surgery in patients with polyglutamine diseases and evaluation of the effects and underlying mechanisms of anesthetics in these patients. Methods: GFP-Htt (Q74)-PC12 cells, which stably express green fluorescent protein-tagged Htt protein containing 74 glutamine repeating units, were used throughout this study. Cells were treated with 15 μM midazolam and 10
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Ishizaki, Junko, and Masaru Mimura. "Dysthymia and Apathy: Diagnosis and Treatment." Depression Research and Treatment 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/893905.

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Dysthymia is a depressive mood disorder characterized by chronic and persistent but mild depression. It is often difficult to be distinguished from major depression, specifically in its partially remitted state because “loss of interest” or “apathy” tends to prevail both in dysthymia, and remitted depression. Apathy may also occur in various psychiatric and neurological disorders, including schizophrenia, stroke, Parkinson's disease, progressive supranuclear palsy, Huntington's disease, and dementias such as Alzheimer's disease, vascular dementia, and frontotemporal dementia. It is symptomatol
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Rodrigues, Eric Cyon. "As Cruzadas e as apropriações contemporâneas da Idade Média (2001 - 2020)." Epígrafe 10, no. 2 (2021): 296–329. http://dx.doi.org/10.11606/issn.2318-8855.v10i2p296-329.

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Após os Ataques de 11 de setembro de 2001, os Estados Unidos iniciaram uma campanha militar de guerra ao terrorismo. Nesse contexto, os conceitos de “choque de civilizações”, cunhado pelo cientista político Samuel Huntington, e o de “cruzadas” se tornaram muito frequentes nos debates políticos e na imprensa. Essas ideias foram apropriadas para definir a natureza dos conflitos entre as nações e o terrorismo. Uma década mais tarde, com a ascensão da extrema-direita brasileira, apropriações semelhantes foram feitas no Brasil. O objetivo deste artigo é analisar como as cruzadas, ocorridas na Idade
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Awaluddin, Awaluddin, Andi Dewi Primayanti, and Belona Danduru Salurante. "PENGUATAN PARTISIPASI PEMILIH DALAM MENGHADAPI PEMILU SERENTAK TAHUN 2024 DI PROVINSI SULAWESI TENGAH." Maleo Law Journal 6, no. 2 (2022): 233–41. http://dx.doi.org/10.56338/mlj.v6i2.2868.

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Participation literally means participation. in a political context this refers to citizens' participation in various political processes. Political participation can also be understood as the process of citizen involvement in all stages of policy, from decision making to decision evaluation, including the opportunity to participate in the implementation of decisions. Widespread political participation is a hallmark of political modernization. The term political participation has been used in various meanings related to behavior, attitudes and perceptions which are an absolute requirement for
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