Academic literature on the topic 'Choriocarcinome'
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Journal articles on the topic "Choriocarcinome"
Périgny, M., S. Trahan, R. Vaillancourt, M. C. Renaud, and C. Couture. "Choriocarcinome primitif pulmonaire." Annales de Pathologie 26, no. 1 (February 2006): 74–75. http://dx.doi.org/10.1016/s0242-6498(06)70679-4.
Full textMohamed Lemine, Meimouna, Beya Mohamed Mahmoud Lemhaba, Nessiba Abdelkader, Karam Mouhammed Saoud, Nessrine Mamouni, Senae Errarhay, Chahrazad Bouchikhi, et al. "CHORIOCARCINOME GESTATIONNEL: A PROPOS DE 2 CAS ET REVUE DE LA LITTERATURE." International Journal of Advanced Research 9, no. 01 (January 31, 2021): 1157–61. http://dx.doi.org/10.21474/ijar01/12403.
Full textKhanfir, A., T. Kaffel, N. Gouiaa, T. Boudawara, M. Abdelmoula, and M. Frikha. "Choriocarcinome gingivo-mandibulaire primitif." Revue de Stomatologie et de Chirurgie Maxillo-faciale 113, no. 5 (November 2012): 382–84. http://dx.doi.org/10.1016/j.stomax.2011.12.001.
Full textCharfi, Slim, Lobna Ayadi, Afef Khanfir, Khaireddine Ben Mahfoudh, Abdelmajid Khabir, Ibticem Bahri, Naourez Gouiaa, et al. "Métastase mammaire d’un choriocarcinome." Imagerie de la Femme 17, no. 2 (June 2007): 129–31. http://dx.doi.org/10.1016/s1776-9817(07)88743-8.
Full textDiouf, A., M. L. Cissé, A. Laïco, D. Ndiaye, J. C. Moreau, and F. Diadhiou. "Aspects échographiques du choriocarcinome gestationnel." Journal de Radiologie 86, no. 5 (May 2005): 469–73. http://dx.doi.org/10.1016/s0221-0363(05)81391-5.
Full textLe Bret, T., P. Tranbaloc, J. L. Benbunan, D. Salet-Lizée, and R. Villet. "Choriocarcinome utérin en péri-ménopause." Journal de Gynécologie Obstétrique et Biologie de la Reproduction 34, no. 1 (February 2005): 85–89. http://dx.doi.org/10.1016/s0368-2315(05)82674-2.
Full textRegis, C., S. Taieb, A. Lesoin, M. C. Baranzelli, T. Blehaut, and E. Leblanc. "Présentation inhabituelle d'un choriocarcinome gestationnel." Gynécologie Obstétrique & Fertilité 34, no. 9 (September 2006): 716–19. http://dx.doi.org/10.1016/j.gyobfe.2006.05.005.
Full textTouboul, C., E. Faivre, C. Boithias, A. E. Mass, M. V. Senat, H. Fernandez, and X. Deffieux. "Hémorragie fœtomaternelle sur choriocarcinome placentaire." Journal de Gynécologie Obstétrique et Biologie de la Reproduction 39, no. 2 (April 2010): 156–58. http://dx.doi.org/10.1016/j.jgyn.2009.10.008.
Full textAucouturier, J. S., G. Bader, G. El Fata, B. Guyot, A. Louboutin, and E. Camus. "Choriocarcinome ovarien : à propos d’un cas." Gynécologie Obstétrique & Fertilité 31, no. 6 (June 2003): 539–42. http://dx.doi.org/10.1016/s1297-9589(03)00134-6.
Full textZerbib, P., E. Prieur, A. Khoury-Helou, P. Catala, F. R. Pruvot, and J. P. Chambon. "Métastases digestives hémorragiques du choriocarcinome testiculaire." Annales de Chirurgie 127, no. 4 (April 2002): 300–301. http://dx.doi.org/10.1016/s0003-3944(02)00743-5.
Full textDissertations / Theses on the topic "Choriocarcinome"
JOPPIN, LEWANDOWKI ELISABETH. "Le choriocarcinome gestationnel a haut risque." Amiens, 1991. http://www.theses.fr/1991AMIEM127.
Full textBourgeat-Faure, Delphine. "Choriocarcinome gestationnel avec enfant vivant à terme." Saint-Etienne, 1995. http://www.theses.fr/1995STET6213.
Full textPoaty, Henriette. "Etude génomique du choriocarcinome gestationnel par aCGH 244K." Paris 6, 2011. http://www.theses.fr/2011PA066641.
Full textGestational Choriocarcinoma, a metastasing tumor, is the major complication of hydatidiform moles (HM) which belong to trophoblastic diseases. The complete HM are diploid and for ten of them, studied by metaphasic CGH, no chromosomal abnormalities were observed. Eleven CC had their diagnosis confirmed by histopathology, and the androgenic etiology by a microsatellite marker analysis, that also confirmed the absence of contamination of tumor DNA by maternal DNA. The samples of DNA from these CC and three cell lines, BeWo, JAR, and JEG were studied by metaphasic CGH and by high resolution 244K aCGH. FISH verifications of chromosomal abnormalities were performed. According to aCGH analysis, the de novo CC exhibited simple chromosomal rearrangements or normal profiles. The cell lines showed various and complex chromosomal aberrations. Chromosomes 1, 11, 14, 17, 18, 19, 20, X Copy Number Anomalies (CNA) were observed in tumors and cell lines, while 5, 7, 8, 9, 10, 12, 16 CNAs were only found in cell lines. Minimal Critical Regions were defined, that allowed to list the genes that were potentially implicated. Testing the expression of several genes by Immunohistochemistry showed a correlation with CNA. Among the MCR, unusually high numbers of microRNA clusters and imprinted genes were observed. Gene disorders caused by abnormal chromosomal imbalances could be superimposed to the initial abnormal expression of imprinted genes
Reynaud, Déborah. "Rôle de la protéine NLRP7 dans la placentation normale et tumorale : cas du choriocarcinome." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAV073.
Full textComplete hydatidiform moles (CHM) are benign precancerous lesions of the placenta that evolve in 5% of cases into a highly proliferative cancer called choriocarcinoma (CC). Numerous studies have reported correlations between the development of recurrent CHM and mutations in the NLRP7 gene. NLRP7 protein belongs the NLRP7-inflammasome, whose activation contributes to the production of mature IL-1 and IL-18. Most of the work published on NLRP7 was focused on the study of NLRP7 mutations in CHM. Though, no study has characterized its role in normal and tumor placental development. The aim of my thesis project was to characterize the role of this protein in the normal and tumor placenta. Three approaches were used, i) A clinical approach, in collaboration with Casablanca University Hospital; the French reference center of Trophoblastic Gestational Disease and with McGill University. These collaborations allowed for tissue access from MHC and CC patients; ii) An in Vitro / Ex Vivo approach for the characterization of the role of NLRP7 in key processes of normal and tumor placental development using 2D and 3D culture systems. Two trophoblastic cell types were used, a non-tumor cell line, the HTR-8 Sv/Neo and the JEG3 cells, derived from human CC; iii) An In Vivo approach through orthotopic injection of JEG3 cells, invalidated or not for the expression of the NLRP7 gene (ShRNA strategy), in the placenta of gravid mice. The tumor impact of JEG3 following their injection into the uterine horn and the vein of the tail of non-pregnant mice was also examined.The first part of my work showed that NLRP7 protein is abundantly expressed in the normal placenta during the first trimester of pregnancy, that its expression is upregulated by hypoxia, a key parameter in placental development, and that this protein controls key processes of placental development such as proliferation and differentiation. Importantly, I have also demonstrated that NLRP7 plays an important compensatory role in the pathology of intrauterine growth retardation. The second part of my work concerning the role of NLRP7 protein in the placental tumor development demonstrated that i) NLRP7 protein levels are increased in the placenta of MHC and CC patients, and that components of the inflammasome machinery are also deregulated, ii) the JEG3 cells overexpress NLRP7 compared to HTR-8 Sv/Neo, iii) NLRP7 knock-down in JEG3 induced a significant decrease in their proliferation and an increase in their migration and invasion both in the 2D and 3D culture systems. The in vivo study demonstrated that the knock-down of NLRP7 decreased the development and metastasis of human CC in the three tested routes. Immunohistological, RNAseq and antibody-array analyses allowed the characterization of the pathways regulated by the NLRP7 protein in JEG3 cells.Altogether my PhD project characterized the critical role of the NLRP7 protein in normal and tumor placental development and proposes the NLRP7 machinery as a potential target for CC treatment
Ricard, Sylvie. "Tumeurs germinales primitives du système digestif : à propos d'un cas." Montpellier 1, 2001. http://www.theses.fr/2001MON11016.
Full textRoussel, Etienne. "Prise en charge des maladies trophoblastiques gestationnelles dans la région Centre entre 1997 et 2001 : Etude rétrospective multicentrique." Tours, 2004. http://www.theses.fr/2004TOUR3062.
Full textMaldonado-Estrada, Juan Guillermo. "Expression membranaire/intracellulaire des récepteurs de chimiokines CXCR4/CCR5 par les cellules de cytotrophoblaste villeux de placenta humain précoce / à terme et de choriocarcinome : effet des cytokines proinflammatoires." Rennes 1, 2002. http://www.theses.fr/2002REN10135.
Full textBellingard, Valérie. "Etude in vitro des relations paracrines entre le stroma de l'endomètre et les cytotrophoblastes : inhibition de la sécrétion endométriale de la prométalloprotéinase-3." Montpellier 1, 1996. http://www.theses.fr/1996MON1T011.
Full textTraboulsi, Wael. "Rôle de l’EG-VEGF (Endocrine Gland Derived-Vascular Endothelial Growth Factor) dans le développement et la progression tumorale placentaire : cas du choriocarcinome." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV039/document.
Full textChoriocarcinoma is a highly malignant trophoblastic tumor that often develop from molar pregnancies also called hydatidiform mole (HM). Nevertheless, HM progression towards choriocarcinoma remains uncharacterized. Involvement of angiogenic factors in this process is proposed. Here, we investigated the role of a new placental angiogenic factor, EG-VEGF (Endocrine Gland-Derived Endothelial Growth Factor) in choricarcinoma pathogenesis. EG-VEGF acts via two GPCR receptors PROKR-1 and PROKR-2. Three approaches were used to verify this hypothesis. A clinical approach using sera and placental samples collected from HM (n=38) and Choriocarcinoma patients (n=3) and from normal pregnant women (n=18); all collected during the first trimester of pregnancy. An In vitro approach using JEG3 cells, a human choriocarcinoma cell line and normal first trimester trophoblast cells (NTC). An in vivo approach that aimed at developing an animal model of choriocarcinoma in which therapeutic agents have been tested. Circulating EG-VEGF levels were significantly higher in HM and choriocarcinoma compared to normal patients. Placental EG-VEGF, PROKR1 and PROKR2 expression exhibited the same pattern. In JEG3 cells, EG-VEGF increased i) the expression of PROKR-1 and PROKR-2, ii). Their migration, proliferation invasion and spheroid formation using both 2 and 3D culture systems. These effects were abolished using PROKR1 and PROKR2 antagonists, iii) phosphorylation of different proteins involved in tumor progression as well as secretion of MMP-2 and MMP-9. Choriocarcinoma model has been developed by injection of JEG3 cells orthotopically within the placenta of SCID mice (Patent in progress). Within 12 days, injected gravid mice developed a choricarcinoma that metastasis in multiple organs. Importantly, injection of EG-VEGF receptors antagonists significantly reduced tumor development and its progression. Also, we have characterized the mechanism by which EG-VEGF contributes to tumor progression. This mechanism involves the cleavage of the key junctional protein, the VE-cadherin, following its phosphorylation at the tyrosine 685, by EG-VEGF. In total my thesis project i) demonstrated the direct involvement of the EG-VEGF in the development and progression of choriocarcinoma ii) elucidated the mechanism of this progression and iii) proposes a potential therapeutic for choriocarcinoma through the antagonisation of its receptors
Bolze, Pierre-Adrien. "Recherche de biomarqueurs prédictifs de l’évolution et de la réponse au traitement dans les maladies trophoblastiques gestationnelles." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSEN016.
Full textHydatidiform moles are a pretumoral placental proliferation which can turn into a tumorrequiring chemotherapy. In order to reduce mortality and propose an optimal therapeuticmanagement, the aim of this thesis is to identify genes which are predictive of postmolartumor transformation and chemoresistance.Concerning the prediction of transformation, the expression analysis of candidate-geneson molar tissue shows a relocalization of Syncytin-1 at the syncytiotrophoblast apicalborder in moles followed by malignant transformation, without modification oftranscription of its receptors and two other retroviral placental envelopes. A wholetranscriptomeapproach using 3 different microarrays-based methods did not identify anydifferentially expressed gene according to the post molar evolution. This may reflect thatinter-individual variability and the different criteria used for tumor diagnosis impede theidentification of robust biomarkers.Concerning the prediction of chemoresistance, a broad-spectrum transcriptomicapproach on choriocarcinoma tumor tissue identifies a down regulation of HLA-G in case of monochemoresistance, confirmed at the protein level by immunohistochemistry.Pathway analysis of the differentially expressed genes suggests thatmonochemoresistance is associated with impaired T-cell differentiation, whereaspolychemoresistance is associated with impaired proliferation of blood cells.Ultimately, the evidence of trophoblastic ubiquitous expression of the PD-L1 immunecheckpoint led us to the evaluation of the efficacy of PD-L1 blockade in chemoresistantpatients. The encouraging results of this trial and the possibility of stratifying patientswith HLA-G and Syncytin-1 markers encourages the assessment of PD-L1 blockadecombined with monochemotherapy as a first line treatment for trophoblastic tumors
Books on the topic "Choriocarcinome"
Palmer, Julie R. Choriocarcinoma. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0050.
Full textAlapetite, Claire, Takaaki Yanagisawa, and Ryo Nishikawa. Germ cell tumours. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199651870.003.0014.
Full textSusan C. Modesitt M.D. (Foreword), ed. Gestational Trophoblastic Neoplasia: A Guide for Women Dealing with Tumors of the Placenta, such as Choriocarcinoma, Molar Pregnancy and Other Forms of GTN. Your Health Press, 2007.
Find full textJohnson, Tara, and Meredith Schwartz Ph D. Gestational Trophoblastic Neoplasia: A Guide for Women Dealing with Tumors of the Placenta, such as Choriocarcinoma, Molar Pregnancy and Other Forms of GTN. Your Health Press, 2012.
Find full textBook chapters on the topic "Choriocarcinome"
Baergen, Rebecca N. "Choriocarcinoma." In Manual of Pathology of the Human Placenta, 447–57. Boston, MA: Springer US, 2010. http://dx.doi.org/10.1007/978-1-4419-7494-5_24.
Full textBenirschke, Kurt, and Peter Kaufmann. "Choriocarcinoma." In Pathology of the Human Placenta, 816–40. New York, NY: Springer New York, 1990. http://dx.doi.org/10.1007/978-1-4757-4193-3_28.
Full textBenirschke, Kurt, and Peter Kaufmann. "Choriocarcinoma." In Pathology of the Human Placenta, 686–708. New York, NY: Springer New York, 1995. http://dx.doi.org/10.1007/978-1-4757-4196-4_23.
Full textBower, M., C. Brock, R. A. Fisher, E. S. Newlands, and G. J. S. Rustin. "Gestational choriocarcinoma." In The Teaching Cases from Annals of Oncology, 111–16. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5456-7_21.
Full textBaldaia, Helena. "Choriocarcinoma, Gastrointestinal." In Encyclopedia of Pathology, 130–32. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-40560-5_1571.
Full textGoldson, Alfred L. "Extragonadal Choriocarcinoma." In Practical Approaches to Cancer Invasion and Metastases, 37–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-84885-8_11.
Full textHui, Pei. "Gestational Choriocarcinoma." In Gestational Trophoblastic Disease, 127–37. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-61779-394-3_8.
Full textSobis, Halina. "Choriocarcinoma, Uterus, Rat." In Genital System, 138–40. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72550-0_21.
Full textOber, William B. "Choriocarcinoma: Historical Notes." In Clinical Perspectives in Obstetrics and Gynecology, 1–7. New York, NY: Springer New York, 1987. http://dx.doi.org/10.1007/978-1-4612-4698-5_1.
Full textWeissferdt, Annikka, and Cesar A. Moran. "Primary Mediastinal Choriocarcinoma." In Encyclopedia of Pathology, 337–41. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-66796-6_12.
Full textConference papers on the topic "Choriocarcinome"
Soni, Abhishek, Nupur Bansal, A. K. Dhull, Vivek Kaushal, and A. K. Chauhan. "Pure primary non gestational choriocarcinoma ovary – diagnostic dilemma and treatment intricacy." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685331.
Full textReis, Baltazar, Bruno da Costa, Marcus de Oliveira, Luís Moraes, Paulo Scaldaferri, and Jair Raso. "Primary Intracranial Choriocarcinoma: Neurorradiological Features." In XXXII Congresso Brasileiro de Neurocirurgia. Thieme Revinter Publicações Ltda, 2018. http://dx.doi.org/10.1055/s-0038-1672775.
Full textYadav, Sushma. "Unusual clinical presentation of chriocarcinoma in young patients – Neulological meatastasis." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685389.
Full text"Gestational choriocarcinoma after term pregnancy: A case report." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685341.
Full textRuggiero, Rosechelle M., and Todd Hoopman. "A Rare Case Of Primary Pulmonary Choriocarcinoma." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3847.
Full textLaw, Jeffrey, Alice Luca, Guihua Zhang, Lynne-Marie Postovit, and Moshmi Bhattacharya. "Abstract 3257: Nodal signalling in choriocarcinoma cells." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3257.
Full textDajao, Michelle Lureineil, and Sherry Joahne Villariasa. "434 Metastatic postmolar choriocarcinoma of the skin." In ESGO SoA 2020 Conference Abstracts. BMJ Publishing Group Ltd, 2020. http://dx.doi.org/10.1136/ijgc-2020-esgo.175.
Full textPeshkova, T., S. Beridze, I. Nakashidze, and K. Kamashidze. "237 Fallopian tube choriocarcinoma: a case report." In IGCS 2020 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2020. http://dx.doi.org/10.1136/ijgc-2020-igcs.203.
Full textLee, B., C. D. Onofrei, and A. Noor. "Diagnosis of a Rare Entity: Primary Pulmonary Choriocarcinoma." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6926.
Full textVizcaíno Gómez, M., R. Betoret Gustems, and E. Cazorla Amorós. "EP1145 Choriocarcinoma after term delivery: a difficult diagnosis." In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.1186.
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