Log in

Relevant bibliographies by topics / Choriocarcinome / Journal articles

To see the other types of publications on this topic, follow the link: Choriocarcinome.

Journal articles on the topic 'Choriocarcinome'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Choriocarcinome.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Périgny, M., S. Trahan, R. Vaillancourt, M. C. Renaud, and C. Couture. "Choriocarcinome primitif pulmonaire." Annales de Pathologie 26, no. 1 (2006): 74–75. http://dx.doi.org/10.1016/s0242-6498(06)70679-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Mohamed Lemine, Meimouna, Beya Mohamed Mahmoud Lemhaba, Nessiba Abdelkader, et al. "CHORIOCARCINOME GESTATIONNEL: A PROPOS DE 2 CAS ET REVUE DE LA LITTERATURE." International Journal of Advanced Research 9, no. 01 (2021): 1157–61. http://dx.doi.org/10.21474/ijar01/12403.

Full text

Abstract:

Le choriocarcinome est une tumeur maligne rare tres metastatique et appartient au groupe des maladies trophoblastiques gestationnelles dont le denominateur commun est une hypersecretion dhormone choriogonadotrope, les maladies trophoblastique gestationnelle regroupent la mole hydatiforme (complete et partielle), la mole hydatiforme invasive, le choriocarcinome gestationnel, la tumeur du site dimplantation placentaire.Nous rapportons 02 cas de choriocarcinome qui ont ete diagnostiquees et prise en charge dans notre formation, a travers ce deux cas nous essayons de faire une mise au point sur cette pathologie.

APA, Harvard, Vancouver, ISO, and other styles

3

Khanfir, A., T. Kaffel, N. Gouiaa, T. Boudawara, M. Abdelmoula, and M. Frikha. "Choriocarcinome gingivo-mandibulaire primitif." Revue de Stomatologie et de Chirurgie Maxillo-faciale 113, no. 5 (2012): 382–84. http://dx.doi.org/10.1016/j.stomax.2011.12.001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Charfi, Slim, Lobna Ayadi, Afef Khanfir, et al. "Métastase mammaire d’un choriocarcinome." Imagerie de la Femme 17, no. 2 (2007): 129–31. http://dx.doi.org/10.1016/s1776-9817(07)88743-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Diouf, A., M. L. Cissé, A. Laïco, D. Ndiaye, J. C. Moreau, and F. Diadhiou. "Aspects échographiques du choriocarcinome gestationnel." Journal de Radiologie 86, no. 5 (2005): 469–73. http://dx.doi.org/10.1016/s0221-0363(05)81391-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Le Bret, T., P. Tranbaloc, J. L. Benbunan, D. Salet-Lizée, and R. Villet. "Choriocarcinome utérin en péri-ménopause." Journal de Gynécologie Obstétrique et Biologie de la Reproduction 34, no. 1 (2005): 85–89. http://dx.doi.org/10.1016/s0368-2315(05)82674-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Regis, C., S. Taieb, A. Lesoin, M. C. Baranzelli, T. Blehaut, and E. Leblanc. "Présentation inhabituelle d'un choriocarcinome gestationnel." Gynécologie Obstétrique & Fertilité 34, no. 9 (2006): 716–19. http://dx.doi.org/10.1016/j.gyobfe.2006.05.005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Touboul, C., E. Faivre, C. Boithias, et al. "Hémorragie fœtomaternelle sur choriocarcinome placentaire." Journal de Gynécologie Obstétrique et Biologie de la Reproduction 39, no. 2 (2010): 156–58. http://dx.doi.org/10.1016/j.jgyn.2009.10.008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Aucouturier, J. S., G. Bader, G. El Fata, B. Guyot, A. Louboutin, and E. Camus. "Choriocarcinome ovarien : à propos d’un cas." Gynécologie Obstétrique & Fertilité 31, no. 6 (2003): 539–42. http://dx.doi.org/10.1016/s1297-9589(03)00134-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Zerbib, P., E. Prieur, A. Khoury-Helou, P. Catala, F. R. Pruvot, and J. P. Chambon. "Métastases digestives hémorragiques du choriocarcinome testiculaire." Annales de Chirurgie 127, no. 4 (2002): 300–301. http://dx.doi.org/10.1016/s0003-3944(02)00743-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Tardif, C., C. Nowak, C. Sagan, J. S. Frenel, and H. J. Philippe. "Présentation anténatale atypique d’un choriocarcinome gestationnel." Gynécologie Obstétrique & Fertilité 42, no. 10 (2014): 725–28. http://dx.doi.org/10.1016/j.gyobfe.2014.07.033.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Cisse, C. T., N. Lo, J. C. Moreau, C. Fall-Gaye, V. Mendez, and F. Diadhiou. "Choriocarcinome au Sénégal : épidémiologie, pronostic et prévention." Gynécologie Obstétrique & Fertilité 30, no. 11 (2002): 862–69. http://dx.doi.org/10.1016/s1297-9589(02)00456-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Sadiki, B., M. A. Lakmichi, A. Fettouh, Z. Dahami, M. S. Moudouni, and I. Sarf. "Choriocarcinome gestationnel révélé par une métastase rénale." African Journal of Urology 20, no. 3 (2014): 158–60. http://dx.doi.org/10.1016/j.afju.2014.03.037.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Ouarssani, A., M. Asseban, M. Ftouhi, and M. I. Rguibi. "Hémoptysie révélant une métastase endobronchique d’un choriocarcinome testiculaire." Revue des Maladies Respiratoires 30, no. 1 (2013): 81–83. http://dx.doi.org/10.1016/j.rmr.2012.06.013.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Olezac, A. S., I. Papanikolaou, L. Bengrine-Lefevre, and C. Chouaid. "Choriocarcinome avec atteinte pulmonaire : stratégie diagnostique et thérapeutique." Revue des Maladies Respiratoires 26, no. 7 (2009): 769–72. http://dx.doi.org/10.1016/s0761-8425(09)72428-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Durieu, I., R. Loire, N. Berger, P. H. Guillaud, and J. F. Cordier. "Métastases pulmonaires hémorragiques controlatérales d'un choriocarcinome pulmonaire primitif." La Revue de Médecine Interne 13, no. 7 (1992): S522. http://dx.doi.org/10.1016/s0248-8663(05)81101-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Emin, L., A. Izard, S. Schiavone, et al. "Transfusion materno-fœtale et diagnostic de choriocarcinome gestationnel." Gynécologie Obstétrique & Fertilité 43, no. 3 (2015): 250–52. http://dx.doi.org/10.1016/j.gyobfe.2015.01.016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Dumesnil, C., E. Gatbois, and G. Leverger. "Le choriocarcinome infantile : une tumeur exceptionnelle et curable." Archives de Pédiatrie 12, no. 12 (2005): 1721–25. http://dx.doi.org/10.1016/j.arcped.2005.09.023.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Kangambega, W., P. Kangambega, J. Helene-Pelage, et al. "Fissuration d’un choriocarcinome révélant la cause d’une hyperthyroïdie." Annales d'Endocrinologie 73, no. 4 (2012): 308. http://dx.doi.org/10.1016/j.ando.2012.07.252.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Vautier-Rit, S., G. Ducarme, L. Devisme, D. Vinatier, and J. L. Leroy. "Choriocarcinome primitif de l'ovaire : à propos d'un cas." Gynécologie Obstétrique & Fertilité 32, no. 7-8 (2004): 620–23. http://dx.doi.org/10.1016/j.gyobfe.2004.05.016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Sahraoui, S., F. Ouhtatou, A. Benider, et al. "P51 Le choriocarcinome du testicule: à propos d'un cas." Cancer/Radiothérapie 2, no. 5 (1998): 630. http://dx.doi.org/10.1016/s1278-3218(98)80124-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Couder, F., F. Golfier, F. Vaudoyer, et al. "Naissance vivante après hystérectomie partielle pour choriocarcinome gestationnel chimiorésistant." Gynécologie Obstétrique & Fertilité 40, no. 6 (2012): 376–78. http://dx.doi.org/10.1016/j.gyobfe.2012.02.006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Inani, K., M. Meziane, Y. Bouyahyaoui, et al. "Le choriocarcinome : une face cachée de la pemphigoïde gestationnelle." Gynécologie Obstétrique & Fertilité 42, no. 5 (2014): 357–59. http://dx.doi.org/10.1016/j.gyobfe.2013.11.003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Poaty, Henriette, Philippe Coullin, Éric Leguern, et al. "Étude cytogénomique de la môle hydatiforme et du choriocarcinome gestationnel." Bulletin du Cancer 99, no. 9 (2012): 827–43. http://dx.doi.org/10.1684/bdc.2012.1621.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Trastour, C., A. Rahili, A. Chevallier, et al. "P174 - Choriocarcinome surrénalien bilatéral : un jeu de piste sans solution ?" Annales d'Endocrinologie 66, no. 5 (2005): 471–72. http://dx.doi.org/10.1016/s0003-4266(05)82015-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Nayama, M., J. P. Lucot, M. Boukerrou, P. Collinet, M. Cosson, and D. Vinatier. "Choriocarcinome tubaire: à propos d'un cas et revue de la littérature." Journal de Gynécologie Obstétrique et Biologie de la Reproduction 36, no. 1 (2007): 83–86. http://dx.doi.org/10.1016/j.jgyn.2006.10.003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Sauvestre, Fanny, Dominique Carles, Martie Faure, et al. "Choriocarcinome gestationnel intra-placentaire de découverte fortuite sur un placenta à terme." Annales de Pathologie 34, no. 2 (2014): 119–23. http://dx.doi.org/10.1016/j.annpat.2014.02.009.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Rao, K. V. L. Narasinga, Subhas Konar, Jagathlal Gangadharan, V. Vikas, and S. Sampath. "A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature." Journal of Neurosciences in Rural Practice 06, no. 04 (2015): 578–81. http://dx.doi.org/10.4103/0976-3147.169780.

Full text

Abstract:

ABSTRACT Choriocarcinoma is the most malignant tumour of gestational trophoblastic origin. Most ovarian choriocarcinomas are gestational in origin and usually metastasize to the ovary from uterine or tubal choriocarcinoma. Non gestational choriocarcinoma (NGOC) of the ovary is exceedingly rare and usually seen along with other germ cell tumors. Non gestational choriocarcinoma has been found to be resistant to single-agent chemotherapy and has a worse prognosis than gestational choriocarcinoma. We are reporting long term follow up of published rare case of pure non gestational ovarian choriocarcinoma (NGOC) with concurrent metastases to the spleen and adrenal glands, who developed a delayed solitary brain metastases, two years after completion of primary treatment. Surgery along with triple agent chemotherapy and radiotherapy was found to give good remission in this aggressive disease.

APA, Harvard, Vancouver, ISO, and other styles

29

Rao, K. V. L. Narasinga, Subhas Konar, Jagathlal Gangadharan, V. Vikas, and S. Sampath. "A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature." Journal of Neurosciences in Rural Practice 06, no. 04 (2015): 578–81. http://dx.doi.org/10.4103/0976-3147.169869.

Full text

Abstract:

ABSTRACTChoriocarcinoma is the most malignant tumour of gestational trophoblastic origin. Most ovarian choriocarcinomas are gestational in origin and usually metastasize to the ovary from uterine or tubal choriocarcinoma. Non gestational choriocarcinoma (NGOC) of the ovary is exceedingly rare and usually seen along with other germ cell tumors. Non gestational choriocarcinoma has been found to be resistant to single-agent chemotherapy and has a worse prognosis than gestational choriocarcinoma. We are reporting long term follow up of published rare case of pure non gestational ovarian choriocarcinoma (NGOC) with concurrent metastases to the spleen and adrenal glands, who developed a delayed solitary brain metastases, two years after completion of primary treatment. Surgery along with triple agent chemotherapy and radiotherapy was found to give good remission in this aggressive disease.

APA, Harvard, Vancouver, ISO, and other styles

30

Sahraoui, S., A. Tahri Joueti Hassani, F. Ouhtatou, A. Acharki, A. Benider, and A. Kahlain. "Choriocarcinome pur du testicule : à propos d'un cas avec revue de la littérature." Annales d'Urologie 35, no. 2 (2001): 125–28. http://dx.doi.org/10.1016/s0003-4401(01)00005-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Mailly, N., J.-P. Delord, A. Dubois, and P. Gandia. "Choriocarcinome placentaire métastatique chez la mère et son nouveau né : à propos d’un cas." Journal de Radiologie 89, no. 4 (2008): 517–20. http://dx.doi.org/10.1016/s0221-0363(08)71458-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Røge, Rasmus, Carsten Simonsen, and Astrid Christine Petersen. "Primary Mediastinal Choriocarcinoma in an Elderly Patient with Concurrent Goserelin-Treated Prostate Adenocarcinoma." Case Reports in Pathology 2019 (May 6, 2019): 1–3. http://dx.doi.org/10.1155/2019/2734815.

Full text

Abstract:

Mediastinal pure choriocarcinomas are exceedingly rare representations of germ cell tumours and are associated with a poor prognosis. To date, fewer than 20 cases have been reported. This current report describes an elderly patient who developed a large rapidly growing mediastinal tumour. Unfortunately, the patient expired before a definitive diagnosis could be reached. An autopsy revealed that the histomorphological features of the tumour showed two distinct tumour cell populations (syncytio- and cytotrophoblasts), and the diagnosis of choriocarcinoma was made. Immunohistochemical analysis showed a characteristic staining pattern in agreement with published studies. Here, we report a case of primary mediastinal choriocarcinoma in an elderly male with concurrent metastasizing prostate adenocarcinoma treated with long-term goserelin deposits, which, as we speculate, could have induced the choriocarcinoma.

APA, Harvard, Vancouver, ISO, and other styles

33

Whaley, Rumeal D., Rachel E. Dougherty, Liang Cheng, and Thomas M. Ulbright. "Fluorescence In Situ Hybridization for the X and Y Chromosome Centromeres Helps Differentiate Between Gestational and Nongestational Choriocarcinoma in Clinically Ambiguous Cases." Archives of Pathology & Laboratory Medicine 144, no. 7 (2019): 863–68. http://dx.doi.org/10.5858/arpa.2019-0207-oa.

Full text

Abstract:

Context.— Gestational choriocarcinoma usually presents during the reproductive years, typically within 1 year of pregnancy, although presentation remote from pregnancy also occurs and may cause confusion with other tumors, including choriocarcinoma of germ cell origin and somatic carcinomas with choriocarcinomatous differentiation. It is important to separate these tumors for treatment and prognostic reasons. Objective.— To assess the utility of fluorescence in situ hybridization for the X and Y chromosome centromeres in determining the gestational origin of clinically ambiguous extrauterine choriocarcinomas in women. Design.— A review of female patients with extrauterine choriocarcinomas who had no evidence of prior gestational trophoblastic disease was performed. Samples were analyzed by fluorescence in situ hybridization for the X and Y chromosome centromeres using standard methodologies. Results.— Five cases met the criteria, all of which displayed trophoblastic cells and necrosis. Three cases (60%) had Y chromosomes by fluorescence in situ hybridization, which confirmed gestational origin. Although the 2 cases without a Y chromosome would ordinarily require molecular genotyping for paternal genetic material to establish gestational origin, in one of these cases a subsequent recurrence of yolk sac tumor allowed confirmation of its mediastinal origin. Conclusions.— Fluorescence in situ hybridization for detection of the X and Y chromosome centromeres is an effective screening test for gestational choriocarcinoma. It provided a definitive diagnosis of metastatic gestational choriocarcinoma in 3 of 5 potential cases that lacked a clinical history of gestational trophoblastic disease. An additional benefit is that more laboratories have the capability to perform fluorescence in situ hybridization than can perform molecular genotyping for definitive diagnosis.

APA, Harvard, Vancouver, ISO, and other styles

34

Goichot, B., T. Petit, F. Grunenberger, et al. "Hyperthyroïdie secondaire à un choriocarcinome : rôle de la sous-unité alpha et évolution sous traitement." La Revue de Médecine Interne 15 (January 1994): 141s. http://dx.doi.org/10.1016/s0248-8663(05)82730-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

de Saint-Denis, T., F. Zairi, L. Thines, P. Bourgeois, and J. P. Lejeune. "Rupture d’anévrisme métastatique de choriocarcinome : à propos de deux cas et revue de la littérature." Neurochirurgie 57, no. 4-6 (2011): 301. http://dx.doi.org/10.1016/j.neuchi.2011.09.162.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Alam, AMM Shariful, Syeda Nurjahan Bhuiyan, and Md Rashid Un Nabi. "Primary Nongestational Choriocarcinoma of the Ovary." Journal of Enam Medical College 4, no. 1 (2014): 56–59. http://dx.doi.org/10.3329/jemc.v4i1.18070.

Full text

Abstract:

Pure primary ovarian choriocarcinoma is an extremely rare and aggressive tumor. It can be of gestational or nongestational in origin. The gestational type can arise from an ovarian pregnancy or can be of metastatic origin from uterine choriocarcinoma. The nongestational type is a very rare germ cell neoplasm. It is important to distinguish between two types of choriocarcinomas as nongestational origin is highly malignant and has worse prognosis than gestational type. But it is very difficult to differentiate by routine histological examination. Nongestational choriocarcinoma has been found to be resistant to single agent chemotherapy. It occurs usually around 13 years of age and is mainly confined to females under 20. Here we report a case of primary pure nongestational choriocarcinoma of the ovary in an unmarried girl of 14 years, diagnosed in 2001 and treated successfully with surgery and combination chemotherapy and remained disease-free till last reporting in September 2013. DOI: http://dx.doi.org/10.3329/jemc.v4i1.18070 J Enam Med Col 2014; 4(1): 56-59

APA, Harvard, Vancouver, ISO, and other styles

37

Vincent, Marjolaine, Isabelle Court-Fortune, Georgia Karpathiou, Marios E. Froudarakis, and Jean-Michel Vergnon. "An Extremely Rare Case of Postpartum Gestational Choriocarcinoma with Long-Term Survival." Tumori Journal 103, no. 1_suppl (2017): S16—S18. http://dx.doi.org/10.5301/tj.5000660.

Full text

Abstract:

Gestational choriocarcinomas are highly malignant tumors with elevated serum human chorionic gonadotropin (hCG) levels. We report an extremely rare case of a 27-year-old woman who presented 4 months after normal delivery, with pulmonary, renal and intracardiac metastases of a choriocarcinoma. No primary uterine tumor was found. She was surgically treated for the renal and cardiac metastases as well as with cisplatin-etoposide chemotherapy. No recurrence has been observed 16 years after initial diagnosis, and the patient was able to have a second child. This case report shows that appropriate treatment of metastatic gestational choriocarcinoma can cure the patient without compromising her fertility.

APA, Harvard, Vancouver, ISO, and other styles

38

Caldas, Rita Ferraz, Paula Oliveira, Cátia Rodrigues, et al. "Intraplacental Choriocarcinoma: Rare or Underdiagnosed? Report of 2 Cases Diagnosed after an Incomplete Miscarriage and a Preterm Spontaneous Vaginal Delivery." Case Reports in Medicine 2017 (2017): 1–4. http://dx.doi.org/10.1155/2017/7892980.

Full text

Abstract:

Intraplacental choriocarcinoma is a rare malignant tumor diagnosed after an abortion, an ectopic pregnancy, or a term or preterm pregnancy or following the diagnosis of a hydatidiform mole. During pregnancy, it may be more common than reported, as most patients are asymptomatic and placental choriocarcinomas are usually inconspicuous macroscopically and are often mistaken for an infarct. Based upon a case study methodology, we describe 2 cases of intraplacental choriocarcinoma: the first case was identified in the product of a uterine curettage following an incomplete miscarriage and the second in one of the placentas of a bichorionic twin pregnancy. Maternal investigation did not reveal evidence of metastatic disease and neither did the infants’ one in the second case. The two cases underwent maternal surveillance with serum hCG and remained disease-free until the present. In conclusion, intraplacental choriocarcinoma is easily underdiagnosed but with current treatment, even in the presence of metastasis, the prognosis is excellent. A routine microscopic examination of all the placentas and products of miscarriage can increase the real incidence of this entity and consequently improve its management.

APA, Harvard, Vancouver, ISO, and other styles

39

Radovanovic, Natasa, Alicia De Castro, Yenong Cao, Hima Reddy Ammana, and Leigh Kwak. "Choriocarcinoma Induced Thyrotoxicosis in a Male Adult." Journal of the Endocrine Society 5, Supplement_1 (2021): A924. http://dx.doi.org/10.1210/jendso/bvab048.1888.

Full text

Abstract:

Abstract Introduction: Germ cell tumors normally occur in the gonads but may be found in extragonadal sites (due to abnormal migration of germ cells during embryogenesis). Metastatic choriocarcionomas are non-seminomatous germ cell tumors which overproduce beta Human Chorionic Gonadotropin (hCG). Rarely, thyrotoxicosis can be driven by germ cell tumor-mediated hCG excess. This hormone binds to the TSH receptor with reduced potency compared to intact TSH. Paraneoplastic thyrotoxicosis, driven by extremely high levels of hCG, is a rare condition which can be associated with choriocarcinomas. Case Presentation: We present a case of 29-year-old man with metastatic extragonadal choriocarcinoma under active treatment with oxaliplatin, paclitaxel, gemcitabine (2 cycles completed), right upper lobe resection and whole brain radiation. He was admitted for small bowel obstruction and persistent tachycardia which prompted evaluation of thyroid function. His initial labs were remarkable for TSH <0.01 mclU/mL (0.27-4.20 mclU/mL), FT4 of 6.38 ng/dL (0.93-1.70 ng/dL), total T3 261 ng/dL (75-170 ng/dL), and beta hCG 578,259 mlU/ML (0-2 mlU/ML). His most recent round of chemotherapy was 7 days prior to admission. He was started on atenolol and methimazole but his FT4 rapidly declined, hence methimazole was stopped after one dose of 40 mg. Sevenfold decrease in FT4 to 0.93 ng/dL correlated with fivefold decrease in beta hCG levels to 98,921 mlU/ML. A week later his FT4 increased to 2.42 ng/dL along with increase of beta hCG to 448,116 mlU/ML. At this point he developed multiple complications due to progressive metastatic disease including acute urinary retention, shortness of breath, abdominal pain, tachycardia, acute anemia and thrombocytopenia, anxiety and was started on methimazole as part of palliative treatment for symptom relief. Unfortunately, he passed away three weeks after initial presentation of thyrotoxicosis due to widespread disease. Discussion: Choriocarcinoma is very rare and aggressive germ cell tumor especially in males. Unfortunately, the widespread nature of choriocarcinomas at the time of diagnosis is a major main reason for poor prognosis. Clinical manifestations of thyrotoxicosis associated with choriocarcinoma such as tachycardia, anxiety, tachypnea are variable and often can overlap with constitutive symptoms in widespread malignancy. Even if a definitive cure of choriocarcinoma is not attainable, recognizing an associated paraneoplastic thyrotoxicosis can provide an important pathway to provide palliative symptom relief.

APA, Harvard, Vancouver, ISO, and other styles

40

Xue, W. C., H. C. Feng, S. W. Tsao, et al. "Methylation status and expression of E-cadherin and cadherin-11 in gestational trophoblastic diseases." International Journal of Gynecologic Cancer 13, no. 6 (2003): 879–88. http://dx.doi.org/10.1136/ijgc-00009577-200311000-00022.

Full text

Abstract:

The clinical significance of cadherins in gestational trophoblastic diseases (GTD) is not fully understood. In this study, the expression of E-cadherin and cadherin-11 in 12 normal placentas, 32 cases of hydatidiform mole (HM) including 15 complete HMs and 17 partial HMs, and five choriocarcinomas was investigated by immunohistochemistry and correlated with follow-up of HMs. Cases with available frozen blocks were further analyzed by western blot and semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR). Methylation of E-cadherin was investigated by methylation-specific PCR in six normal first trimester placentas, 19 HMs and their associated deciduas. E-cadherin expression was localized to cytotrophoblast and intermediate trophoblast whereas cadherin-11 was expressed in syncytiotrophoblast, intermediate trophoblast, and decidua. Immunoreactivity of E-cadherin was reduced in choriocarcinoma and complete HM when compared with that in normal first trimester placenta (P < 0.01, P = 0.04). Hypermethylation of E-cadherin was demonstrated in three complete HMs with the lowest level of E-cadherin. Compared with normal first trimester placenta, immunoreactivity of cadherin-11 was higher in complete HM (P = 0.02), but lower in choriocarcinoma (P = 0.02). Such differential expression was confirmed by western blot and semiquantitative RT-PCR. No obvious association was observed between the development of persistent trophoblastic disease with the expression of E-cadherin and cadherin-11.

APA, Harvard, Vancouver, ISO, and other styles

41

Farman, C. A., K. Benirschke, M. Horner, and P. Lappin. "Ovarian Choriocarcinoma in a Rhesus Monkey Associated with Elevated Serum Chorionic Gonadotropin Levels." Veterinary Pathology 42, no. 2 (2005): 226–29. http://dx.doi.org/10.1354/vp.42-2-226.

Full text

Abstract:

A clinically normal, 3-year-old female rhesus monkey ( Macaca mulatta), which was part of a routine toxicology study, had a mass in the right ovary with metastases to the adjacent mesentery and lungs. The histologic features and immunohistochemistry results were consistent with the diagnosis of choriocarcinoma. Neoplastic cell types included cytotrophoblast (positive for cytokeratin), syncytiotrophoblast (positive for human chorionic gonadotropin), and extravillous trophoblast (positive for human placental lactogen). Because the neoplasm was present in the ovary, the uterus was normal, and the animal was not currently pregnant, this was considered a primary ovarian neoplasm of germ cell origin. The monkey had elevated serum levels of chorionic gonadotropin at the beginning of the study, indicating that, as in women, choriocarcinomas in monkeys can be associated with increased gonadotropin levels and that the tumor was preexisting at the start of the toxicology study.

APA, Harvard, Vancouver, ISO, and other styles

42

Barreda Bolaños, Fernando, Humberto Liu Bejarano, Jéssica Alférez Andía, Roxana Inoñan García, Henry Guerra Miller, and Eduardo Payet Meza. "Coriocarcinoma gástrico primario: reporte de caso." Horizonte Médico (Lima) 19, no. 2 (2019): 93–96. http://dx.doi.org/10.24265/horizmed.2019.v19n2.12.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Jacques, Suzanne M., Faisal Qureshi, Barbara J. Doss, and Adnan Munkarah. "Intraplacental Choriocarcinoma Associated with Viable Pregnancy: Pathologic Features and Implications for the Mother and Infant." Pediatric and Developmental Pathology 1, no. 5 (1998): 380–87. http://dx.doi.org/10.1007/s100249900052.

Full text

Abstract:

Choriocarcinoma arising in the placenta, or intraplacental choriocarcinoma, has seldom been reported, particularly in the absence of maternal metastases. Reluctance to diagnose choriocarcinoma in the presence of chorionic villi can delay diagnosis; however, timely diagnosis of choriocarcinoma is prognostically important, both for the mother and infant. We report the clinicopathologic findings in five mothers and infants in whom choriocarcinoma was identified in the placenta. None of the mothers had a history of gestational trophoblastic disease in previous pregnancies. Three placentas were similar with a single small lesion grossly suggesting a small infarct; microscopically these consisted of infarcted areas surrounded by choriocarcinoma. These three mothers were unusual in that none had metastatic choriocarcinoma; two were treated with chemotherapy and remained disease-free; the third was lost to follow-up shortly following delivery. The remaining two mothers had known pulmonary metastases at time of delivery. One of these latter two placentas contained a large marginal lesion microscopically identified as choriocarcinoma. The fifth placenta had rare microscopic foci of choriocarcinoma, and sheets of necrotic choriocarcinoma were identified in “blood clot” submitted with the placenta. In four of the five cases the choriocarcinoma appeared to be arising from otherwise normal chorionic villi, and in no case was there invasion of the villous stroma. All of the infants survived, and none had evidence of choriocarcinoma. These cases support the concept that choriocarcinoma associated with otherwise normal pregnancy arises in the placenta and may be more common than reported.

APA, Harvard, Vancouver, ISO, and other styles

44

N. R., Sindhu, and Shraddha Shetty. "Choriocarcinoma presenting following a molar pregnancy and preterm vaginal delivery: rarest of rare case." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 2 (2021): 781. http://dx.doi.org/10.18203/2320-1770.ijrcog20210343.

Full text

Abstract:

Choriocarcinoma is the aggressive histologic type of GTN and is characterized by vascular invasion and metastases of widespread. Choriocarcinoma metastasizes hematogenously. Suction and evacuation were done on admission. Beta-hCG was 67900 mIU/ml and 144523 mIU/ml on day 1 and day 3 respectively and histopathology showed Choriocarcinoma. This is very unusual case of reviewing sequential events. It was difficult to detect is it new pregnancy or choriocarcinoma. Investigators were biased with high beta-hCG values indicating malignancy. So there was differential diagnosis as choriocarcinoma based on history of molar pregnancy and increasing beta-hCG value and also dictum of 'non molar pregnancy following live birth is always choriocarcinoma. However histopathology report suggested choriocarcinoma and was diagnostic.

APA, Harvard, Vancouver, ISO, and other styles

45

Graham, Charles H., and Peeyush K. Lala. "Mechanisms of placental invasion of the uterus and their control." Biochemistry and Cell Biology 70, no. 10-11 (1992): 867–74. http://dx.doi.org/10.1139/o92-135.

Full text

Abstract:

Trophoblast cells of the placenta in many species have acquired mechanisms to invade the uterus, inclusive of its blood vessels, to establish efficient fetomaternal exchange of molecules. This invasion is strictly controlled both spatially and temporally and, in humans, usually continues until midgestation. Key mechanisms underlying various steps in trophoblast invasion are (i) the attachment to the basement membrane, most likely by binding to laminin; (ii) the detachment from the basement membrane matrix, a process requiring the presence of complex-type oligosaccharides on the cell surface; and (iii) the breakdown of basement membrane components, mediated by secretion of metalloproteases (such as type IV collagenases) and serine proteases (plasminogen activator). Activation of trophoblast-derived metalloproteases appears to be plasmin dependent. Trophoblast invasiveness in situ is controlled by the microenvironment, owing to local production of anti-invasive factors by the decidual tissue of the uterus. One of these factors is TIMP (tissue inhibitor of metalloproteases), which neutralizes metalloproteases in an equimolar ratio. Another is TGF-β (transforming growth factor-β), which has a dual effect: it induces TIMP-1 secretion by the trophoblast and decidual cells and promotes differentiation of invasive trophoblast cells into multinucleated giant cells, which are presumably noninvasive. Thus, TGF-β provides the key control of trophoblast invasiveness in situ. This control is lost in certain choriocarcinomas. In contrast to the response shown by the normal trophoblast, JAR and JEG-3 choriocarcinoma cell invasiveness does not seem to be inhibited by TGF-β. In fact, in preliminary studies, JAR cells responded to TGF-β by increased invasiveness. The reasons for the differential effects of TGF-β on normal versus malignant trophoblast cell invasiveness are currently under study.Key words: trophoblast, invasion, control, choriocarcinoma, transforming growth factor-β.

APA, Harvard, Vancouver, ISO, and other styles

46

Pullar, Michael, Peter C. Blumbergs, Gael E. Phillips, and Paul G. Carney. "Neoplastic cerebral aneurysm from metastatic gestational choriocarcinoma." Journal of Neurosurgery 63, no. 4 (1985): 644–47. http://dx.doi.org/10.3171/jns.1985.63.4.0644.

Full text

Abstract:

✓ This case of metastatic gestational choriocarcinoma presented as intracerebral hemorrhage from an atypical distal middle cerebral artery aneurysm. Operative evacuation of the intracerebral hematoma was undertaken and histopathological examination revealed choriocarcinoma invading the vessel wall. Neoplastic cerebral aneurysms are unusual, being reported in metastatic choriocarcinoma, cardiac myxoma, bronchogenic carcinoma, and undifferentiated carcinoma. Metastatic choriocarcinoma should be considered in the differential diagnosis of intracerebral hemorrhage in women of child-bearing age. Recent advances in treatment have resulted in a 75% cure rate for metastatic choriocarcinoma.

APA, Harvard, Vancouver, ISO, and other styles

47

Lee, Eunhyun, and Hyunjin Cho. "A Case of Intraplacental Choriocarcinoma with Pulmonary Metastasis." Case Reports in Oncology 12, no. 3 (2019): 802–6. http://dx.doi.org/10.1159/000503816.

Full text

Abstract:

Intraplacental choriocarcinoma is a rare type of gestational choriocarcinoma occurring in the placenta, of which only a small number of cases have been reported. Gestational choriocarcinoma rapidly metastasizes to organs such as the lung, brain, and liver; thus, early diagnosis and treatment are essential. In addition, intraplacental choriocarcinoma can affect fetal mortality. We present a case of a 33-year-old woman diagnosed with intraplacental choriocarcinoma based on placental biopsy performed after the pregnancy had reached term. The patient had pulmonary metastasis at the time of diagnosis, but after the combination chemotherapy with EMA-EP, complete remission is maintained.

APA, Harvard, Vancouver, ISO, and other styles

48

Brooks, Timothy, and Laura Nolting. "Cutaneous Manifestation of Metastatic Infantile Choriocarcinoma." Case Reports in Pediatrics 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/104652.

Full text

Abstract:

Infantile choriocarcinoma is a highly malignant rare germ cell tumor that arises from the placenta. Simultaneous intraplacental choriocarcinoma involving both mother and infant is extremely rare. Cutaneous metastasis in infantile choriocarcinoma is even rarer with only a few case reports available. Here we describe a case of a female neonate who presented to the ED with a rapidly growing and bleeding vascular lesion to her right cheek. She was eventually diagnosed by biopsy with metastatic choriocarcinoma. In addition to the cutaneous tumor, she also had metastatic disease in her lungs. Her mother was subsequently found to have choriocarcinoma with metastatic disease to the lungs as well.

APA, Harvard, Vancouver, ISO, and other styles

49

Manandhar, Tara, Rakchya Upreti, and Sarita Sitaula. "Choriocarcinoma associated with ectopic pregnancy. A case report." Birat Journal of Health Sciences 4, no. 3 (2020): 873–76. http://dx.doi.org/10.3126/bjhs.v4i3.27045.

Full text

Abstract:

Choriocarcinoma is an uncommon malignant neoplasia and even rarer is the Choriocarcinoma associated with ectopic pregnancy. Here, we present a case of Choriocarcinoma in a young lady who had undergone laparoscopic salphingectomy for rupture ectopic pregnancy, and presenting after 2month in hemorrhagic shock requiring urgent laparotomy.

APA, Harvard, Vancouver, ISO, and other styles

50

Nandan, Neetha, Kishan Prasad, Mubeena Begum, and Supriya Rai. "Primary tubal choriocarcinoma." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 6 (2018): 2509. http://dx.doi.org/10.18203/2320-1770.ijrcog20182379.

Full text

Abstract:

Choriocarcinoma is extremely aggressive form of gestational trophoblastic disease. It occurs due to neoplastic changes in the chorionic villi. The most common site of origin is uterus but rarely can occur in tube, cervix or ovary. Tubal choriocarcinoma may develop either by malignant transformation of a tubal pregnancy or can arise denovo without an ectopic pregnancy. The reported incidence of tubal choriocarcinoma is approximately 1.5/1,000,000 births. Here, we report a case in which salphingectomy was done thinking it was an acute ectopic pregnancy, but histopathological examination showed tubal choriocarcinoma. This tubal choriocarcinoma occurred denovo and was not secondary to an ectopic pregnancy. Patient did not need adjuvant chemotherapy as it was detected early and is being followed up by β-hcg monitoring.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!