Relevant bibliographies by topics / CHR 2002

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Academic literature on the topic 'CHR 2002'

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Published: 4 June 2021
Last updated: 12 February 2022

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Journal articles on the topic "CHR 2002"

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Kuhnert, Nikolai, Nicolai Burzlaff, Eberhard Dombrowski, and Wolfdieter A. Schenk. "Cationic Ruthenium-Sulfine Complexes: Synthesis and Dynamic Behaviour." Zeitschrift für Naturforschung B 57, no. 3 (March 1, 2002): 259–74. http://dx.doi.org/10.1515/znb-2002-0302.

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AbstractCationic ruthenium sulfine complexes [CpRu(PR´3)2(O=S=CHR)]PF6 have been obtained by a variety of methods. Oxidation of the thioaldehyde complexes [CpRu(PR´3)2(S=CHR)]PF6 with either 2-tosyl-3-phenyl-oxaziridine (PR´3 = PMe3 ) or magnesium-monoperoxyphthalate (PR´3 = 1/2 dppm) gave complexes of arylsulfines (R = Ph, 3-C6H4F, 4-C6H4Cl, 4- C6H4OMe) selectively in their thermodynamically less stable E form. Siloxane elimination from the sulfinato complexes [CpRu(PMe3)2(SO2CHRSiMe3)] yielded complexes of aliphatic sulfines, [CpRu(PMe3)2(O=S=CHR)]PF6 (R =H,Me). Treatment of [CpRu(dppm)(SO2CH2R)] with acetyl chloride led to an oxygen redistribution giving complexes of thioaldehydes [CpRu(dppm)(η2-S=CH2)]PF6 and [CpRu(dppm)(η1-S=CHR)]PF6 (R = Ph, 4-C6H4Cl). The structure of the latter was determined by X-ray crystallography. The loss of oxygen can be suppressed by performing the acylation-elimination sequence in the presence of poly-(4-vinylpyridine). This provided a selective access to complexes of Z-sulfines, [CpRu(PMe3)2(O=S=CHR)]PF6 (R = Ph, 4-C6H4Cl) and [CpRu(dppm)(O=S=CHR)]PF6 (R = Ph, 4-C6H4Cl, COOEt, Cl). Complexes of the parent sulfine O=S=CH2 were also obtained by SO transfer to the methylene complex [CpRu(PMe3)2(CH2)]PF6 and methylene transfer to the sulfur monoxide complex [Cp*Ru(PMe3)2 (SO)]PF6. Most of the new sulfine complexes exhibit dynamic behaviour in solution, i. e. ligand rotation, ligand inversion, and η2 /η1 hapticity change. O-Alkylation provided the dicationic complex [CpRu(PMe3)2 (EtO-S=CHMe)](PF6)2, and S-oxidation gave the sulfene complexes [(C5R5)Ru(PMe3)2 (O2S=CH2)]PF6 (R = H, Me).
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KITLV, Redactie. "Book Reviews." Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia 160, no. 1 (2004): 124–88. http://dx.doi.org/10.1163/22134379-90003737.

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-Barbara Watson Andaya, Susan Blackburn, Love, sex and power; Women in Southeast Asia. Clayton VIC: Monash Asia Institute, 2001, iv + 144 pp. [Monash papers on Southeast Asia 55.] -Kathryn Gay Anderson, Juliette Koning ,Women and households in Indonesia; Cultural notions and social practices. Richmond, Surrey: Curzon, 2000, xiii + 354 pp. [Nordic Institute of Asian studies, studies in Asian topics 27.], Marleen Nolten, Janet Rodenburg (eds) -Greg Bankoff, Takeshi Kawanaka, Power in a Philippine city. Chiba: Institute of developing economies, 2002, 118 pp. [IDE Occasional papers series 38.] -René van den Berg, John Lynch ,The Oceanic languages. Richmond, Surrey: Curzon, 2002, xvii + 924 pp., Malcolm Ross, Terry Crowley (eds) -H.J.M. Claessen, Douglas Oliver, Polynesia in early historic times. Honolulu: Bess Press, 2002, 305 pp. -Harold Crouch, Andrew Rosser, The politics of economic liberalisation in Indonesia; State, market and power. Richmond, Surrey: Curzon, 2002, xv + 232 pp. -Hans Hägerdal, Arend de Roever, De jacht op sandelhout; De VOC en de tweedeling van Timor in de zeventiende eeuw. Zutphen: Walburg Pers, 2002, 383 pp. -Fiona Harris, Lorraine V. Aragon ,Structuralism's transformations; Order and revision in Indonesian and Malaysian societies; Paper written in honor of Clark E. Cunningham. Tempe AZ: Arizona State University Press, 1999, lxii + 402 pp., Susan D. Russell (eds) -David Henley, Christiaan Heersink, Dependence on green gold: A socio-economic history of the Indonesian coconut island Selayar. Leiden: KITlV Press, 1999, xviii + 371 pp. [Verhandelingen 184.] -David Hicks, James T. Siegel ,Southeast Asia over three generations; Essays presented to Benedict R.O'G. Anderson 2003, 398 pp. Ithaca NY: Cornell University Southeast Asia program. [Studies on Southeast Asia 36.], Audrey R. Kahin (eds) -Janny de Jong, L. de Jong, The collapse of a colonial society; The Dutch in Indonesia during the second world war. With an introduction by Jeroen Kemperman. Leiden: KITLV Press, 2002, 570 pp. [Verhandelingen 206.] -Gerry van Klinken, Grayson Lloyd ,Indonesia today; Challenges of history. Singapore: Institute of Southeast Asian studies, 2001, 359 pp., Shannon Smith (eds) -Johanna van Reenen, Frédéric Durand, Timor Lorosa'e, pays au carrefour de l'Asie et du Pacifique; Un atlas géo-historique. Marne-la-Vallée: Presses Universitaires de Marne-la-Vallée, 2002, 208 pp. -William R. Roff, Mona Abaza, Debates on Islam and knowledge in Malaysia and Egypt; Shifting worlds. London: RoutledgeCurzon, 2002, xix + 304 pp. -Mariëtte van Selm, Chr. van Fraassen ,G.E. Rumphius, De Ambonse eilanden onder de VOC, zoals opgetekend in 'De Ambonse landbeschrijving'. Utrecht: Landelijk Steunpunt Educatie Molukkers, 2002, 254 pp., H. Straver (eds) -K. Thirumaran, Prema-Chandra Athukorala, Crisis and recovery in Malaysia; The role of capital controls. Cheltenham: Elgar, 2001, xii + 159 pp. -K. Thirumaran, John Hilley, Malaysia; Mahathirism, hegemony and the new opposition. London: Zed books, 2001, xiii + 305 pp. -Reina van der Wiel, Damien Kingsbury ,Foreign devils and other journalists. Clayton VIC: Monash Asia Institute, 2000, vi + 277 pp. [Monash papers on Southeast Asia 52.], Eric Loo, Patricia Payne (eds) -Jennifer Fraser, Philip Yampolsky, Music of Indonesia. Washington DC: Smithsonian Folkways recordings, 1991-2000, 20 compact discs plus a CD of selections from the series, Discover Indonesia. All with accompanying booklets. -Robert Wessing, Nicola Tannenbaum ,Founders' cults in Southeast Asia; Ancestors, polity, and identity. New Haven CT: Yale University Southeast Asian studies, 2003, xi + 373 pp. [Yale Southeast Asia studies Monograph 52.], Cornelia Ann Kammerer (eds) -Robert Wessing, Henri Chambert-Loir ,The potent dead; Ancestors, saints and heroes in contemporary Indonesia. Crows Nest, New South Wales: Allen and Unwin, Honolulu: University of Hawai'i Press, 2002, xxvi + 243 pp. [Southeast Asia publications series.], Anthony Reid (eds)
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Hasford, Joerg, Gianantonio Rosti, Doris Lindoerfer, Michele Baccarani, Joelle Guilhot, Lara Montrucchio, Francesca Rancati, et al. "Outcome and Prognosis of 1955 Patients with Chronic Myeloid Leukemia: First Results of the CML-Registry of the European Treatment and Outcome Study EUTOS." Blood 114, no. 22 (November 20, 2009): 1109. http://dx.doi.org/10.1182/blood.v114.22.1109.1109.

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Abstract Abstract 1109 Poster Board I-131 The main objective of the CML-Registry of the European Treatment and Outcome Study (EUTOS) is to collect diagnostic, treatment and outcome data of CML-patients in Europe in order to allow for the analysis of prognostic factors, the evaluation of the quality of care and the comparative assessment of outcomes. Methods Eligibility criteria were: diagnosis of chronic phase Ph+ or bcr/abl positive CML between 2002 and 2006, age ≥ 18 years, and start with any kind of imatinib-based treatment in a prospective study within six months after first diagnosis. For hematologic (HR), cytogenetic (CgR), and molecular (MR) remission the ELN criteria were used. Competing risk estimations and Landmark analyses were applied when indicated. Patients from the FI-LMC-group in France (n=526), Germany (n=644), Italy (n=513), The Netherlands (n=119), the Nordic Countries (Denmark, Finland, Norway, Sweden, n=140)) and Switzerland (n=13) were included (date: 07/11/2009), for an overall n of 1955 patients. Results Median age was 52.5 years and 45% were female. The Euro prognostic score profile was for 38% of the patients low, for 51% intermediate and for 11% high risk. Imatinib 400 mg was allocated to 41%, Imatinib 600 mg to 8%, Imatinib 800 mg to 17%, and Imatinib-based combinations with IFN or Ara C to 34% of the patients. Median observation time was 24 months (range: 1-81). Complete hematologic remission (CHR) was finally achieved by 97%, complete cytogenetic remission (CCgR) by 94%, and major molecular remission (MMR) after 18 months by 62%. Overall survival (OS) after 60 months was 92%. Euro score clearly separated high risk vs. non high risk patients with regard to CHR (p=.0002), CCgR (p=.0023), but not for MMR, whereas Sokal score did so for CCgR (p<.0001). Deletion 9q did not show any impact on CHR, CCgR or MMR. Using Landmark-analysis with those 1012 patients who provided complete data for CHR, CCgR and MMR, CHR within 6 months from day 1 of imatinib treatment showed an impact on the chance to achieve CCgR (96.1% vs. 87.5% p=.0003) and MMR at 18 month (56.1% vs. 48.5%, p=.087). CHR within 3 months did not show a relevant impact on CCgR and MMR. Partial CgR (Ph+ < 35%, n=725)) within 6 months was associated with a higher chance to achieve MMR at 18 month (62.8% vs. 51.4% p=.0003). Patients who did not achieve CCgR within 3 (93%), 6 (70%), 12 (29%) or 18 (18%) months experienced an increasing risk for disease progression of 6%, 7%, 11% and 14% respectively but still showed a chance to eventually achieve CCgR of 87%, 83%, 60%, and 36%. Conclusions: This combined analysis of multinational European data showed very good response data regarding CHR, CCgR, MMR, and OS. Current prognostic CML scores seem to not separate prognosis of CML-patients sufficiently well. Early response markers like CHR and CgR after 6 months allow to differentiate the prognosis with regard to MMR but their clinical relevance may be questioned. Patients without CCgR within 6 months have a higher risk for disease progression and thus a closer follow up is indicated. With accumulating observation time the European CML Registry will allow to answer many clinically relevant questions about the prognostic value of early response markers. Disclosures Hasford: Novartis Pharma: Research Funding. Rosti:Novartis Pharma, Bristol Myers Squibb: Consultancy, Speakers Bureau. Baccarani:Novartis Pharma, Bristol Myers Squibb, Merck Sharp & Dome, Pfizer: Consultancy, Speakers Bureau. Montrucchio:Novartis Pharma : Employment. Rancati:Novartis Pharma: Employment. Simonsson:Novartis, BMS, Schering-Plough: Consultancy, Honoraria, Research Funding. Ossenkoppele:Novartis Pharma, BMS: Consultancy. Hehlmann:Novartis Pharma: Research Funding.
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Pagnano, Katia BB, Marcia T. Delamain, Eliana C. M. Miranda, Vagner O. Duarte, Brunna Eulálio Alves, Carmino Antonio De Souza, and Irene Lorand-Metze. "Impact of Imatinib Dose Escalation in Chronic Myeloid Leukemia Patients in Chronic Phase with Sub-Optimal Response or Failure with Imatinib 400 Mg." Blood 114, no. 22 (November 20, 2009): 3289. http://dx.doi.org/10.1182/blood.v114.22.3289.3289.

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Abstract Abstract 3289 Poster Board III-1 Imatinib dose escalation has been used in sub-optimal response and therapeutic failure to imatinib in conventional doses. The aim of this study was to evaluate the efficacy of imatinib dose increase in CML patients in CP who did not achieve the best response to imatinib 400 mg QID. Patients and methods: All CML patients in CP treated in our institution with imatinib 400mg between March 2002 and December 2008 were evaluated. Imatinib was escalated to 600–800mg in cases with sub-optimal response or failure, according to Leukemia Net or IRIS Trial criteria. All survival curves were calculated from date of dose increase: overall survival (OS) until death or last follow-up, event free survival (EFS) until loss of complete hematological response (CHR) or major cytogenetic response (MCyR), progression to accelerated phase (AP) or blast crisis (BC) or death from any cause. Transformation free survival (TFS) was calculated from dose increase until progression to AP, BC or death. Results: 137 patients in CP were treated with imatinib 400 mg. Dose was escalated in 55 (40%) patients due to loss or failure to achieve CRH (13 = 24%); progression to BC (2 = 3.5%); no CCR (11 = 20%); loss of RCC (5 = 9%); CCR without major molecular response (MMR) after 18 months of imatinib (24 = 43.5%). Males: 37, females 18 cases. Median age: 44 (16–74) years. Twenty-eight patients (49%) were treated with imatinib as first line therapy and 51% had used IFN previously. Median time between diagnosis and imatinib start was 4.5 (0–94) months. Responses: 94% achieved CHR; 58% CCR and 34% MMR. After dose increase, 31 (56%) responded: 58% of the patients with previous sub-optimal molecular response achieved MMR. Among those who benefited from dose increase, only 3 cases lost the response: one with hematological resistance and two with cytogenetic resistance (2 lost CCR and one CHR). Seven out of 16 patients who increased dose due to cytogenetic failure (loss of response, failure and sub-optimal response) achieved response: one had partial cytogenetic response (PCyR) and 6 CCR. Five patients with hematological failure presented response: CHR (2), CCR (1), PCyR (1) and MMR (1). Patients with BC (2 cases) did not respond to dose escalation. TFS was 89% and 67% in 2 and 5 years, respectively. EFS was 71% and 64% in 2 and 5 years respectively. When stratified by the type of failure, EFS was 100%, 49% and 34% in the group with molecular sub-optimal response with median time of 22 (4–41) months, cytogenetic 17 (1.2–42) and hematological failure 7.7 (0.2–57), respectively (P<0.03). Conclusions: imatinib dose escalation was successful in molecular sub-optimal response. However, the patients who do not achieve MMR might be candidates to second line treatment. Patients who did not achieve cytogenetic or hematological response did worse with imatinib dose escalation. Disclosures: No relevant conflicts of interest to declare.
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Murugan, M., P. K. Shetty, Thomas George, R. Ravi, A. Subbiah, and K. Vijayakumar. "Pesticide Use in Indian Cardamom Hills." International Journal of Social Ecology and Sustainable Development 5, no. 3 (July 2014): 65–80. http://dx.doi.org/10.4018/ijsesd.2014070106.

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Surveys and analyses among cardamom and tea planters were carried out in and around cardamom hill reserves during 2009-2012 to quantify the annual pesticide consumption of cardamom and tea. The survey revealed that cardamom had consumed 26.59 kg a.i ha-1 in comparison with tea (8.70kg a.i ha-1). Pesticide intensity of cardamom (0.0322 kg kg-1) was higher than tea (0.0046 kg kg-1). Risk weighed active ingredients values were 3.326 and 0.029 kg ha-1 for cardamom and tea respectively. The pesticide use intensity in major cardamom growing areas of the CHR has experienced significant increase from 2002 and 2003. It was 7.10 kg a.i ha-1 in the year 2002 and decreased slightly to 5.42 kg a.i ha-1 for the year 2003. The number of pesticide sprays has been increased during the last two years (2011-2012). Pesticide residues in soils of all three cardamom growing hot spots were high. Hospital data of these cardamom hot spot regions showed higher levels of pesticide poisonings particularly for organophosphorous compounds. Therefore, the analysis and results reported here on pesticide consumption by cardamom and tea must be taken seriously to safeguard the degraded rainforest cardamom agroforestry system.
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Avitia, Miguel Angel Alvarez, Jose Luis Aguilar Ponce, Gisell Anaid Lara, Violeta Moreno Molina, Jaime G. De La Garza, Martin Granados-Garcia, Juan Cruz M, Andres Moran Mendoza, and Abraham Ruiz. "Induction chemotherapy (ICh) followed by concurrent chemoradiotherapy (ChR) in locally advanced squamous cell carcinoma of head and neck (SCCHN): Experience in a Mexican institute." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): e17031-e17031. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e17031.

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e17031 Background: ICh has taken an important role in the treatment of locally advanced disease, but it has not been recognized in which patients (pts) may be the best option ICh followed by ChR or just ChR. We present our experience with ICh followed by ChR regimen in the National Cancer Institute of Mexico (INCan). Methods: We identified 69 patients (pts) diagnosed with locally and/or regionally advanced non-metastatic squamous cell cancer of head and neck, who were attended at the INCan from 2008-2012, in whom, the original treatment was ICh with two cycles of Paclitaxel (P), cisplatin (C) and 5Fluorouracil (5FU) scheme, followed by concurrent ChR with C. But only 35 pts of the original group accomplished the treatment. Results: 13 pts were women (37%) and 22 were men (63%).The median age at diagnosis was 59 years old. In stages III (28%), IVa (46%), and IVb (26%); AJCC, 2002. The subsites per pts. studied were: oral cavity 9 (25.7%), larynx 9 (25.7%), hypopharynx 7 (20%), paranasal sinuses 7 (20%) and oropharynx 3 (8.6%). The rate response was observed in 83%: complete objective rate response (CR) in13 pts (37%), partial response rate in 16 pts (46%) and progression rate in 6 pts. (17%). The mean survival was of 18.3 months (mth) (CI-95: 0.32-0.68).Median survival was not achieved in pts with CR with a median follow up of 2 yrs, pts with PR had a median survival of 15 mth (CI-95: 0.27-0.75) and the median progression was 11 mth (CI-95: 0.11-0.80). We have not got any CR with ICh only, but 13 patients obtained CR at the end of the ChR. Neither age, sex nor subsites were crucial to the clinical response. Conclusions: Our results cannot distinguish patients who might benefit from ICH. In the intention-to-treat population, more than a half of pts did not complete the proposed scheme. Recently, we reported a study using an alternative scheme: Cisplatin and gemcitabine concurrent with radiotherapy to treat pts with advanced SCCHN, and we found that this scheme of treatment is effective and well tolerated, with a 5 yr progression-free survival rate of 27.8 (CI-95: 0–61.5). Yet further studies are needed to compare ICh followed by RCh vs RCh to assess what the best treatment may be.
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Ferrari, Anna, Cristina Papayannidis, Carmen Baldazzi, Ilaria Iacobucci, Stefania Paolini, Antonella Padella, Viviana Guadagnuolo, et al. "Leukemia Associated TP53 Mutations in AML Patients ARE Strongly Associated with Complex Karyotype and Poor Outcome." Blood 124, no. 21 (December 6, 2014): 2379. http://dx.doi.org/10.1182/blood.v124.21.2379.2379.

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Abstract Background: AML is a heterogeneous disease with various chromosomal aberrations. The karyotype at diagnosis provides important prognostic information that influences therapy and outcome, and patients (pts) with complex karyotype (CK) have generally a poor outcome. TP53 is the most frequently mutated gene in human tumors. The reported TP53 mutation rate in AML is low (2.1%). In contrast, the incidence of TP53 mutations in AML with a complex aberrant karyotype is higher (69-78%). Aims: To investigate the frequency, the types of mutations, the associated cytogenetic abnormalities and the prognostic role of TP53 mutations in adult AML pts, we focused the screening on subgroups of AML with chromosome abnormalities. Patients and Methods: 886 AML patients were analysed at the Seràgnoli Institute of Bologna between 2002 and 2013 for morphology, immunophenotype, cytogenetic and for a panel of genetic alterations (FLT3, NPM, WT1, CBF fusion transcripts, DNMT3A, IDH1, IDH2, etc). Of these, 172 adult AML pts were also examined for TP53 mutations using several methods, including Sanger sequencing, Next-Generation deep-Sequencing (Roche) and HiSeq 2000 (Illumina) platform (35/172 pts). 40 samples were genotyped with Genome-Wide Human SNP 6.0 arrays or with CytoScan HD Array (Affymetrix) and analysed by Nexus Copy Number™ v7.5 (BioDiscovery). Results: Of the 886 AML patients beforehand analysed, 172 pts were screened for TP53 mutations and were correlated with cytogenetic analysis (excluding 15 pts where the karyotype was not available). 1. Fifty-two pts (30,2%) have 3 or more chromosome abnormalities, i.e. complex karyotype; 2. 71 (41,3%) presented one or two cytogenetic abnormalities (other-AML) and 3. 34 pts (19,8%) have normal karyotype. Sanger sequencing analysis detected TP53 mutations on 29 patients with 36 different types of mutations; seven pts (4%) have 2 mutations. Mostly (23/29) of the TP53 mutated pts (79.3%) had complex karyotype while only 6/29 mutated pts have “no CK” (21% and 3% of the entire screened population). Overall, between pts with complex karyotype, TP53 frequency is 44.2%. Regarding the types of the TP53 alterations, 32 were deleterious point mutations (http://p53.iarc.fr/TP53GeneVariations.aspx) and 4 deletions. Forty pts were also analysed for Copy Number Alterations (CNAs) by Affymetrix SNP arrays: several CNAs were found ranged from loss or gain of complete chromosome (chr) arms to focal deletions and gains targeting one or few genes involving macroscopic (>1.5 Mbps), submicroscopic genomic intervals (50 Kbps - 1.5 Mbps) and LOH (>5 Mbps) events. Of relevance, gains located on chr 8 were statistically associated with TP53 mutations (p = 0.001). Seven genes are included in these regions (RGS20, TCEA1, LINC01299, ARMC1, MTFR1, RAD54B, KIAA1429). In addition to the trisomy of the chr 8, others CNAs, located on other chromosomes are significantly associated (p = 0.05) with TP53 mutations: loss of chr 5q, chr 3 (p22.3), chr 12 (p12.3) and the gain of chr 17 (p11.2), chr 16 (p11.2-11.3) and chr 14 (q32.33). The zinc finger gene ZNF705B, implicated in the regulation of transcription was the most differentially associated gene (gain). WES analysis was done in 37 pts, 32 TP53 were wt while 5 pts were TP53 mutated: of importance, CDC27, PLIN4 and MUC4 were found also mutated in 3 out of 5 TP53 mutated (60%). Clinical outcome: as previously reported, alterations of TP53 were significantly associated with poor outcome in terms of both overall survival and disease free-survival (P < 0.0001). Conclusions: Our data demonstrated that TP53 mutations occur in 16.86% of AML with a higher frequency in the subgroup of complex karyotype AML (p< 0.0001–Fischer’s exact test). Since TP53 mutations have predicted to be deleterious and significantly correlated with prognosis, TP53 mutation screening should be recommended at least in complex karyotype AML pts. Furthermore, although further studies in larger numbers of patients are needed, the gain of chromosome 8 was observed to be significantly associated to TP53 mutations pts. Supported by: ELN, AIL, AIRC, PRIN, progetto Regione-Università 2010-12 (L. Bolondi), FP7 NGS-PTL project. Disclosures Martinelli: Novartis: Speakers Bureau; Bristol Mayers Squibb: Speakers Bureau; Pfizer: Speakers Bureau.
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Hehlmann, Ruediger, Susanne Saussele, Michael Lauseker, Ulrike Proetel, Elena Kovalevskaya, Armin Leitner, Claudia Haferlach, et al. "Randomized Comparison of Imatinib 400 Mg Vs. Imatinib + IFN Vs. Imatinib + AraC Vs. Imatinib after IFN Vs. Imatinib 800 Mg: Optimized Treatment and Survival. Designed First Interim Analysis of the German CML Study IV." Blood 112, no. 11 (November 16, 2008): 184. http://dx.doi.org/10.1182/blood.v112.11.184.184.

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Abstract In spite of favorable response and survival results for the majority of CML patients on imatinib therapy, in a substantial minority imatinib fails or shows suboptimal responses. A treatment optimization study was therefore designed to compare in a randomized fashion standard imatinib vs. imatinib + interferon alpha (IFN) vs. imatinib + low dose araC vs. imatinib after IFN (for low- and intermediate-risk patients) or vs. imatinib 800 mg (for high-risk patients). Inclusion criteria were newly diagnosed BCR/ABL positive CML in chronic phase. In July 2005, randomization to the arms imatinib + araC and imatinib after IFN was discontinued and recruitment for imatinib 800 mg was expanded to low- and intermediate-risk patients. Primary goals are: rates of hematologic, cytogenetic and molecular remissions, duration of chronic phase, overall survival, adverse events and analysis of subsequent allografting. Since its activation in 7/2002, 1203 patients have been randomized. The current evaluation represents the first of three designed, statistically adjusted interim analyses of 710 patients randomized by the end of 2005 with a followup of at least 2 years. Analysis was according to intention to treat. 666 patients (545 with primary imatinib, 121 with primary IFN) were evaluable for hematologic, 621 for cytogenetic, and 631 for molecular responses. Median age was 53 years, 60% were male, median values were for Hb 12.5 g/dl, WBC 71.2/nl and platelets 384/nl, 35% had low, 53% intermediate and 12% high risk (Euro score). Median observation time was 3.5 years. Median duration of IFN pretreatment was &lt;4 months. At 1 year, the cumulative incidence of complete hematologic remission (CHR) was 82.3% and 74.4%, of major cytogenetic remission (MCR) 65.6% and 40.6%, of complete cytogenetic remission (CCR) 52% and 19.7%, and of major molecular remission (MMR) 33.2% and 4.7% for primary imatinib and IFN therapies, respectively. At 3 years, the cumulative incidence of CHR was 96.4% and 93.8%, of MCR 89.5% and 89.1%, of CCR 85.2% and 78.5%, and of MMR 79% and 63% for primary imatinib and IFN therapies, respectively. 5-year-survival probability of all patients currently exceeds 90% (94% for imatinib-, 91% for IFN-based therapy, Figure 1). Event free survival after two years (no progression, no death, CCR within the first 18 months, no loss of CHR or MCR) was 80.3%. 36 patients died, 51 patients were transplanted in first chronic phase, and 80 patients progressed, 43 of which were switched to alternative treatments (16 to new drugs, 18 to transplantation, 9 received both). Type and severity of adverse events (AE) did not significantly differ from those reported previously. Hematologic AEs (leukopenia, thrombocytopenia) were most frequent in the imatinib 800 mg arm. Nonhematologic AEs (gastrointestinal) were most frequent in the combination arms and with imatinib 800 mg. In no case recruitment had to be changed due to superiority or inferiority of any arm. This applies also to the high dose imatinib arm where earlier response might translate into better survival. In conclusion, this first interim analysis shows favorable survival and long term response rates. Imatinib in combination with, or after, IFN or with low dose araC are feasible and equally safe treatment alternatives. More definite information will be provided by the next interim evaluation after recruitment has been terminated. Figure Figure
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Ganesan, Prasanth, Tenali Gnana Sagar, Krishnarathnam Kannan, and Rejiv Rajendranath. "Upfront Imatinib in Pediatric Chronic Myeloid Leukemia Yields Results Comparable to Stem Cell Transplant,." Blood 118, no. 21 (November 18, 2011): 3763. http://dx.doi.org/10.1182/blood.v118.21.3763.3763.

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Abstract Abstract 3763 Background: Imatinib mesylate (IM) is the standard therapy in adult patients with chronic myeloid leukemia (CML). In children, the superiority of Imatinib over allogenic transplantation is not well established. Concerns exist about the long term effects of Imatinib in this population. Methods: Outcomes of children (≤18 years) diagnosed with chronic phase CML from 2002 to 2008 were retrospectively analysed. All received Imatinib at a dose of 260–300mg/m2/day. Progression free survival (PFS- time from starting treatment till loss of complete hematologic response (CHR), or disease acceleration), ad Overall survival (OS) were estimated by the Kaplan Meier method. Those who progressed received higher doses of Imatinb or were changed to hydroxyurea. No patient had access to second line tyrosine kinase inhibitors or to allogenic stem cell transplant. Results: 31 patients, median age 13 (6–18)years, Males-17 (48.6%), were treated. The presenting complaints over a median symptom duration of 1 month (10 days to 12 months) were abdominal distension and/or pain (68%), fever (38%), weight loss (13%), bone pains (10%), anemic symptoms (16%). Examination revealed splenomegaly (100%), heptomegaly (47%) and lymphadenopathy (6%). Laboratory: Hemoglobin (9.3g/dL;4.2–10.9), White cell count (228,000/mm3;10,000–800,000), Platelet count (412,000/mm3, 120,000–12,80,000), peripheral eosinophilia (2%;0–10), basophilia (2%; 0–7). CHR was seen in 30/31 (97%) at a median of 2 months (1.5–8). Sokal risk category was low in 13 (41%), intermediate in 15 (48.4%) and high in 3 (9.7%). The cumulative incidence of Major and Complete cytogenetic response (MCR and CCR) among those who had not progressed by 2 years (n=23) was 82% and 70% respectively. Molecular assessment done in 11 patients who had achieved CCR by 2 years showed MMR in 6/11 (55%). After a median follow up of 49.2 months (4.4 – 86.4) disease progression occurred in 8 patients (5-year PFS 68%-median not reached) which led to death in 6 patients (5-year OS 75.8%). Among those with cytogenetic data, the PFS for those with CCR vs those without was 93.8% and 53.6 % respectively at 5 years (p=0.048). The drug was well tolerated with no discontinuation because of toxicity. Conclusions: Imatinib is a reasonable option in the first line therapy of pediatric CML and gives 5 year PFS and OS rates comparable to the results of upfront allogenic transplant. It is to be considered as an alternative especially in resource constrained settings where options for transplant are limited. Disclosures: No relevant conflicts of interest to declare.
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Rea, Delphine, Gabriel Etienne, Franck Emmanuel Nicolini, Pascale Cony-Makhoul, Hyacinthe Johnson-Ansah, Laurence Legros, Francoise Huguet, et al. "Front-Line Imatinib Mesylate (IM) in Patients with Newly Diagnosed Accelerated Phase (AP)-Chronic Myeloid Leukemia (CML), a Study From the FILMC Group (France Intergroupe Leucemie Myeloide Chronique)." Blood 114, no. 22 (November 20, 2009): 3288. http://dx.doi.org/10.1182/blood.v114.22.3288.3288.

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Abstract Abstract 3288 Poster Board III-1 IM is approved for the treatment of AP-CML at 600mg daily. Clinical trials in which IM was evaluated in this setting have mainly enrolled patients (pts) who have failed prior therapies and the efficacy of the drug in newly diagnosed AP-CML has never been specifically studied. We collected data from 43 de novo pts with disease acceleration at diagnosis and treated with first-line IM. Thirty-three showed hematological acceleration (HEMAP) according to WHO 2002 or ELN 2006 criteria and 10 had cytogenetic acceleration only (CYAP), defined as the presence of chromosomal abnormalities additional (ACA) to the Philadelphia (Ph) chromosome. Ph variant translocations, loss of the Y chromosome and constitutional cytogenetic abnormalities were excluded from ACA definition. Ten out of 33 HEMAP pts (30%) had also ACA. ACA included Ph duplication (n=4), trisomy 8 (n=5), add(6) (n=3), monosomy 7 (n=1), del(5q) (n=1), t(3;21)(q26;q22) (n=1) and others (n=7). Median age at diagnosis was 51 years (19–67), 32 pts were males (75%) and 11 were females (25%). The median time from diagnosis to IM initiation was 15 days (0–140). The initial IM dose was 600mg/d (n=32) or 400mg/d (n=11). The median duration of IM therapy was 20 months (1–90). A sustained complete hematologic response (CHR) for at least 4 weeks was achieved in 38/43 pts (88.4%, 95% CI 78.4–99.3), including 29 HEMAP and 9 CYAP pts (87.9% versus 90%, not significant (ns)). The median time to achievement of CHR was 42 days (0–97). CHR was lost in 3 pts after 4, 6 and 10 months. Pts with lack or loss of CHR were initially classified as HEMAP (n=5) or CYAP (n=3), all except one harboured ACA at diagnosis. In addition, 4/7 screened pts had a BCR-ABL mutation (E255K n=3, E355G n=1) at the time of IM failure. A major cytogenetic response (MajCR) was observed in 31/43 patients (72.1%, 95% CI 58.1–86.1), and a complete cytogenetic response (CCR) was obtained by 27/43 pts (62.8 %, 95% CI 44.7–78.8), with 22 HEMAP pts and 5 CYAP pts (66.6% versus 50%, ns). The median time to reach CCR was 6 months (3–23). The rate of CCR in HEMAP pts with ACA was significantly lower than that in HEMAP pts without ACA (36.4% vs 80%, p=0.023). Eighteen pts with CCR (16 HEMAP pts and 2 CYAP pts) also gained a major molecular response (MMR: BCR-ABL/ABL ratio % IS ≤ 0.1%). The median time to MMR was 9 months (5–34). Seven pts subsequently lost their MajCR (CCR n=3, partial CR n=4) 3 to 31 months after first achieving it, 2 due to a poor compliance to IM and 5 due to acquired resistance. Of the latter, 4/5 had ACA at diagnosis and a BCR-ABL mutation emerged in 3/5 (E355G n=1, E255K n=1 and T315I n=1). Four pts (2 HEMAP and 2 CYAP) who failed to achieve CHR or CCR evolved toward blast crisis (BC) while on IM, after 1 to 11 months of treatment. The event-free survival (EFS) rate on IM was 57.1% (95% CI 41.4–72.7) at 24 months, events being defined as lack/loss of response, BC or death, whichever came first. The progression-free survival (PFS) rate on IM was 89.7% (95% CI 80–99.4) at 24 months, progression being defined as BC or death. EFS and PFS and did not significantly differ between HEMAP and CYAP pts but EFS at 24 months was significantly poorer in HEMAP pts with ACA at diagnosis than that in HEMAP pts without ACA (26% vs 74.7%, p=0.0055). Twenty-three out of 43 (53.5%) pts discontinued IM after a median duration of treatment of 11 months (1–90), because of treatment failure/progression (n=14), intolerance (n=8) or undetectable molecular residual disease (UMRD, n=1). For those on continuous IM therapy, the median observation time was 32 months (3–76). Following IM discontinuation, 15 pts were switched to second generation tyrosine kinase inhibitors (TKI) and 2 of them evolved toward BC and died, 3 pts underwent allogeneic hematopoietic stem cell transplantation, 4 pts received intensive chemotherapy with or without TKI and 1 was further transplanted, and the last pt with UMRD remained treatment-free. To conclude, although IM front-line induces substantial and durable responses in de novo AP-CML, our results suggest that there may be room for further improvement, especially in case of HEMAP together with ACA. The potential of other front-line therapies such as second generation TKI may be evaluated in this setting. Disclosures: No relevant conflicts of interest to declare.
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Dissertations / Theses on the topic "CHR 2002"

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Weiß, Norman. "Martin H. W. Möllers ; Robert Chr. van Ooyen (Hrsg.): Jahrbuch Öffentliche Sichterheit 2004/2005 / [rezensiert von] Norman Weiß." Universität Potsdam, 2005. http://opus.kobv.de/ubp/volltexte/2011/5642/.

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Keller, Derek Lawrence Baraka Imamu Amiri. "Fear ego love : (2002-2004) for amplified mixed quartet, rock band, and chamber choir /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3166409.

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Thesis (Ph. D.)--University of California, San Diego, 2004.
Amplified quartet consists of flute, guitar, violoncello, and percussion; chamber choir for a minumum of 16 performers, SSSSAAAATTTTBBBB. Text fragments taken from Black magic by Amiri Baraka. Includes performance instructions preceding score. Vita.
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Baimatova, Nasiba. "Die Kunst des Wölbens in Mittelasien Lehmziegelgewölbe (4.-3. Jt. v. Chr. - 8. Jh. n. Chr.) /." [S.l. : s.n.], 2004. http://www.diss.fu-berlin.de/2004/148/index.html.

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Ndem, Imo F. "Trend Analysis of Automobile Collision Amongst 15-19 year olds in Virginia, 2000-2004." VCU Scholars Compass, 2007. http://hdl.handle.net/10156/1624.

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Ess, Hans van. "Politik und Gelehrsamkeit in der Zeit der Han (202 v. Chr.-220 n. Chr.) : die Alttext/Neutext-Kontroverse /." Wiesbaden : Harrassowitz Verlag, 1993. http://catalogue.bnf.fr/ark:/12148/cb40112040k.

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Ragones, Timothy. "A content analysis of the on-air language of CNN election night coverage in 2000 and 2002 /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1422957.

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Gonçalves, Thais Souza. "Monetarização de gases poluentes de veículos do ciclo Otto no Brasil de 2000 a 2009." Universidade Federal do Tocantins, 2015. http://hdl.handle.net/11612/581.

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O agravamento de inúmeros problemas ambientais nas últimas décadas – contaminação do ar e da água, epidemias, secas prolongadas, enchentes, incêndios florestais, perdas da qualidade do solo, desastres nucleares e químicos, o crescimento do buraco na camada de ozônio e a atual escassez de água – têm emitido alertas a gestores e sociedade sobre a devida responsabilidade acerca dos recursos naturais. Nesse sentido, a valoração ou monetarização da emissão dos principais poluentes veiculares é fundamental para a formulação de políticas públicas ambientais, de gestão de transporte e trânsito que busquem resultados mais efetivos no controle das emissões. Esse trabalho apresenta uma breve discussão sobre as emissões veiculares de poluentes e as principais políticas públicas adotadas no setor e das emissões evitadas pelo uso do álcool carburante. Apresentou uma metodologia de cálculo baseada no quantitativo da frota de veículos, da intensidade de uso, dos fatores de emissão e dos valores monetários de referência de monóxido de carbono, óxido de nitrogênio, hidrocarbonetos e material particulado. Como resultado, apresenta-se as análises com seus respectivos valores das emissões referentes ao quantitativo monetário dos gases selecionados. Com o aumento do carro com tecnologia flex-fuel, observou-se a redução das emissões totais dos gases poluentes, embora a frota tenha aumentado em valores absolutos. Os valores monetários calculados por meio dos Indicadores de Monetarização de Emissões demonstraram que o monóxido de carbono é o principal responsável das emissões por automóveis que utilizam o ciclo Otto no Brasil, representando 45,7% das emissões e o valor monetário foi de R$ 4.736.386.753,28. Os hidrocarbonetos são o segundo gás mais emitido pela frota de automóveis, sendo responsável por 27,3% das emissões, e valor monetário de R$ 2.835.304.578,20. Em seguida surgem as emissões de óxido de nitrogênio, que em teve suas emissões reduzidas em 26,8% e foi responsável por R$ 2.785.548.815,02. Já as emissões de material particulado, em 2000 foram de R$ 705.307,57. Com a redução de 23%, foram responsáveis por R$ 545.752,13. Pode-se verificar, também, que o custo ambiental do período de 2000 a 2009, provocado pela frota de automóveis do ciclo Otto, dedicados ou de tecnologia flex-fuel, movidos à gasolina C e etanol hidratado, foi de R$ 10.363.277.869,40.
The worsening of numerous environmental problems in recent decades - contamination of air and water, epidemics, prolonged droughts, floods, forest fires, loss of soil quality, nuclear and chemical disasters, the hole growth in the ozone layer and the current shortage water - have issued alerts to managers and society on the proper responsibility about natural resources. In this sense, the valuation or monetization of emission of key vehicle pollutants is essential for the formulation of environmental policies, transportation management and traffic that seek more effective results in controlling emissions. This paper presents a brief discussion on vehicle emissions of pollutants and major public policies adopted in the industry and emissions avoided by the use of fuel ethanol. Presented a calculation method based on the amount of the vehicle fleet, the intensity of use, emission and monetary values of carbon monoxide reference factors, nitrogen oxides, hydrocarbons and particulate matter. As a result, the analysis is presented with the respective emission values for the quantitative currency of selected gases. With increasing car with flex-fuel technology, there was a reduction of total emissions of greenhouse gases, although the fleet has increased in absolute terms. The monetary values calculated using the emissions of monetization indicators showed that carbon monoxide is primarily responsible for emissions from motor vehicles the Otto cycle in Brazil, representing 45.7% of the emissions and the monetary value was R $ 4,736 .386.753,28. Hydrocarbons are the second most gas emitted by the car fleet, accounting for 27.3% of emissions, and monetary value of R $ 2,835,304,578.20. Then come the emissions of nitrogen oxide, which had its emission reductions of 26.8% and accounted for R $ 2,785,548,815.02. While emissions of particulate matter in 2000 were R $ 705,307.57. With the reduction of 23%, accounted for R $ 545,752.13. You can also check that the environmental cost for the period 2000-2009, caused by the fleet of vehicles of the Otto cycle, dedicated or flex-fuel technology, moved to C gasoline and hydrous ethanol was R $ 10,363,277,869 40.
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Reid, Jennifer Lea. "Obesity and associated cardiovascular disease risk factors the impact on American Indians residing in Southern California, 2002-2006 /." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3352690.

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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2009.
Title from first page of PDF file (viewed June 16, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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Moura, Luciana. "An empirical study of the impact of Opec announcements on stock returns of selected sector indexes of the Stockholm stock market 2005-2007." Thesis, Södertörns högskola, Institutionen för samhällsvetenskaper, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-11552.

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This study presents an observation of the impact of Opec announcements on the behavior of sector indexes returns of the Stockholm stock market. It looks at the effects of the announcements on the stock returns of three sectors indices of theStockholm stock market: Energy, Telecommunications and Financial using the general market index return (OMX Stockholm 30) as the explanatory variable. The time period analyzed is limited to the years of 2005 to 2007 when markets worldwide were taken by euphoria and panic caused by the anticipation of the upcoming financial crisis given that it has been well proved that such events do cause a substantial effect on stock prices. In order to estimate the reaction of the sector index returns over Opec announcements, the author uses the event studies and constructs an extended version of the CAPM model by introducing dummy variables for each day of the set of announcements over the event window. It is used stationary time series data and the returns on the three sector indices were subdivided in an event window of 5 days around the announcement dates in continuous intervals of 3 years according to the Stockholm stock market trading days. As to improve the results obtained with the CAPM model, the author uses the Cumulative Abnormal Returns (CAR) which adds all the coefficients of the dummy variables which are the returns in excess of what is expected. The empirical findings for the event study reveal that none of the dummy variable coefficients were significant which indicate that none of the sector indexes is sensitive to the announcements. For the CAR results, the Telecommunication was the only sector that responded to news. Most likely because the general market index OMXST30 has proved to create extra returns around these dates. That is probably the reason that the three sector indexes could not produce significant additional response.
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Weiss, Martin. "Politik im Vorfeld von Irak-Krieg und Zweitem Makedonischen Krieg : ein historischer Vergleich zwischen den USA und der Römischen Republik /." Hamburg : Diplomica-Verl, 2007. http://d-nb.info/98655622X/04.

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Books on the topic "CHR 2002"

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Damsté, Christiaan Paul. Chr. Paul Damsté: 65 jaar ; assemblages und collages 2002-2009. [Emmerich]: Skulpturen-Achse Hochelten-Kleve e.V., 2009.

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It takes a worried man: Stories. Dallas: Southern Methodist University Press, 2002.

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Research, Construction Forecasting and. CFR Construction Forecasts 2003-2004. London: Experian Business Strategies, 2003.

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Che Lovelace: Paintings, 2004-2008. Trinidad and Tobago: Robert & Christopher, 2008.

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Beijing ban shi cha xun: 2002-2003. [Lhasa?]: Xizang ren min chu ban she, 2001.

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Britain), Commission for Health Improvement (Great. Lessons from CHI investigations 2000-2003. London: TSO, 2004.

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CHF Center for Contemporary History and Policy. Research report, 2004-2006. Philadelphia, Pa: Chemical Heritage Foundation, 2007.

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CHF Center for Contemporary History and Policy. Research report, 2004-2006. Philadelphia, Pa: Chemical Heritage Foundation, 2007.

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Yŏsŏngbu, Korea (South). Che 2-chʻa yŏsŏng chŏngchʻaek kibon kyehoek (2003-2007) 2004-yŏndo sihaeng silchŏk mit 2005-yŏndo sihaeng kyehoek. [Seoul]: Yŏsŏngbu, 2005.

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Kingdom of the instant. Boston: Houghton Mifflin, 2002.

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Book chapters on the topic "CHR 2002"

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Wixom, Robert L., and Charles W. Gehrke. "Today's Chromatographers and their Discoveries (2000-2008)." In Chromatography, 101–98. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470555729.ch5.

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Ottmann, Henning. "Polybios (ca. 200–120 v. Chr.)." In Geschichte des politischen Denkens, 52–69. Stuttgart: J.B. Metzler, 2002. http://dx.doi.org/10.1007/978-3-476-03759-6_3.

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Marthinsen, John E. "Four Paradoxes of the 2008-2009 Economic and Financial Crisis." In Lessons from the Financial Crisis, 59–67. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118266588.ch9.

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Dalmijn, W. L., and J. A. van Houwelingen. "Car scrap recycling towards 2000." In EMC ’91: Non-Ferrous Metallurgy—Present and Future, 265–71. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3684-6_27.

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Jahoda, Pavel, Jan Cech, and Jiri Matas. "Autonomous Car Chasing." In Computer Vision – ECCV 2020 Workshops, 337–52. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-66823-5_20.

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Wolf, Armin. "Adaptive Constraint Handling with CHR in Java." In Principles and Practice of Constraint Programming — CP 2001, 256–70. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/3-540-45578-7_18.

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Bernsen, Niels Ole. "User Modelling in the Car." In User Modeling 2003, 378–82. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/3-540-44963-9_52.

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Fu, Yuxi, and Zhenrong Yang. "Chi Calculus with Mismatch." In CONCUR 2000 — Concurrency Theory, 596–610. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/3-540-44618-4_42.

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Wogan, Peter. "Car Crash." In Corner-Store Dreams and the 2008 Financial Crisis, 25–29. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-52264-7_5.

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Peter, Hadrian, and Charles Greenidge. "Data Extraction from Deep Web Sites." In Encyclopedia of Internet Technologies and Applications, 142–49. IGI Global, 2008. http://dx.doi.org/10.4018/978-1-59140-993-9.ch021.

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Traditionally a great deal of research has been devoted to data extraction on the web (Crescenzi, et al, 2001; Embley, et al, 2005; Laender, et al, 2002; Hammer, et al, 1997; Ribeiro-Neto, et al, 1999; Huck, et al, 1998; Wang & Lochovsky, 2002, 2003) from areas where data is easily indexed and extracted by a Search Engine, the so-called Surface Web. There are, however, other sites that are greater and potentially more vital, that contain information which cannot be readily indexed by standard search engines. These sites which have been designed to require some level of direct human participation (for example, to issue queries rather than simply follow hyperlinks) cannot be handled using the simple link traversal techniques used by many web crawlers (Rappaport, 2000; Cho & Garcia-Molina, 2000; Cho et al, 1998; Edwards et al, 2001). This area of the web, which has been operationally off-limits for crawlers using standard indexing procedures, is termed the Deep Web (Zillman, 2005; Bergman, 2000). Much work still needs to be done as Deep Web sites represent an area that is only recently being explored to identify where potential uses can be developed.
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Conference papers on the topic "CHR 2002"

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Farmer, J. C., J. J. Haslam, S. D. Day, T. Lian, R. Rebak, N. Yang, and L. Aprigliano. "Corrosion Resistance of Iron-Based Amorphous Metal Coatings." In ASME 2006 Pressure Vessels and Piping/ICPVT-11 Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/pvp2006-icpvt-11-93835.

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New amorphous-metal thermal-spray coatings have been developed recently that may provide a viable coating option for spent nuclear fuel & high-level waste repositories [Pang et al. 2002; Shinimiya et al. 2005; Ponnambalam et al. 2004; Branagan et al. 2000–2004]. Some Fe-based amorphous-metal formulations have been found to have corrosion resistance comparable to that of high-performance alloys such as Ni-based Alloy C-22 [Farmer et al. 2004–2006]. These materials rely on Cr, Mo and W for enhanced corrosion resistance, while B is added to promote glass formation and Y is added to lower the critical cooling rate (CCR). Materials discussed in this paper include yttrium-containing SAM1651 with CCR ∼ 80 K/s and yttrium-free Formula 2C with CCR ∼ 600 K/s. While nickel-based Alloy C-22 and Type 316L stainless steel lose their resistance to corrosion during thermal spraying, Fe-based SAM1651 and Formula 2C amorphous-metal coatings can be applied with thermal spray processes without any significant loss of corrosion resistance. In the future, such corrosion-resistant thermal-spray coatings may enable the development of less expensive containers for spent nuclear fuel (SNF) and high-level waste (HLW), including enhanced multipurpose containers (MPCs), protected closure welds, and shields to protect containers from drips and falling rocks. These materials are extremely hard and provide enhanced resistance to abrasion and gouges from backfill operations. For example, Type 316L stainless steel has a hardness of approximately 150 VHN, Alloy C-22 has a hardness of approximately 250 VHN, while the Fe-based amorphous metals typically have hardness values of 1100–1300 VHN. Both Formula 2C and SAM1651 have high boron content which allow them to absorb neutrons, and therefore be used for enhanced criticality control. Cost savings can also be realized through the substitution of Fe-based alloy for Ni-based materials. Applications are also envisioned in oil & gas industry.
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Odermatt, Daniel, Thomas Heege, Jens Nieke, Mathias Kneubuhler, and Klaus Itten. "MERIS Chl-a Timeseries of Lake Constance 2003-2006." In IGARSS 2008 - 2008 IEEE International Geoscience and Remote Sensing Symposium. IEEE, 2008. http://dx.doi.org/10.1109/igarss.2008.4779855.

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Taşdoğan, Celal, and Bilgen Taşdoğan. "Emissions Responsibility and Relative Importance of the Productive Sectors in Turkey: 2002-2011." In International Conference on Eurasian Economies. Eurasian Economists Association, 2014. http://dx.doi.org/10.36880/c05.01095.

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Turkey has realized high growth rates during the period of 2002-2011, except in 2008 and 2009 years. It is thought that the rapidly growing in the country may cause a lot of environmental damage, especially air pollution problems. In other words, the productive sectors have produced two outputs which are economic value added and air pollutants. This study used input output matrixes are to find out the strategically important sectors as it is known key sectors and weak sectors caused the environmental effects in the country. For this purpose, it has been tried to investigate air pollutant quantities which caused by the production process of the sectors in the period of 2002-2011 and performed the input-output tables for Turkey constructed in the World Input Output Database (WIOD) Project. These input-output tables include the emission satellite accounts, which are CO2 emissions and other air pollutants, respectively N2O, CH4, N2O, NOx, SOx, CO, NMVOC and NH3, disaggregated for the 34 sectors. It is expected that the outcomes of the study may contribute to sustainable growth debates and environmental policy implementations in Turkey.
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Tam Dao, N. H., and V. Vinh Duong. "TEC and Scintillation observed over Ho Chi Minh, Vietnam during 2009-2012." In 2013 International Conference on Space Science and Communication (IconSpace). IEEE, 2013. http://dx.doi.org/10.1109/iconspace.2013.6599511.

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Kurata, Osamu, Norihiko Iki, Takayuki Matsunuma, Tetsuhiko Maeda, Satoshi Hirano, Katsuhiko Kadoguchi, Hiromi Takeuchi, and Hiro Yoshida. "Start Time Control of Micro Gas Turbine CHP System With Heat Storage." In ASME 2011 Power Conference collocated with JSME ICOPE 2011. ASMEDC, 2011. http://dx.doi.org/10.1115/power2011-55372.

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Combined heat and power (CHP) systems are widely used considering the prevention of global climate change and the reduction of energy costs. In distributed CHP systems, both high efficiency of elements and good coordination of the systems are considered as the points to solve. We had been researched and demonstrated the micro gas turbine CHP system with heat storage at Sapporo City University from April 2006 to March 2010. At first, the start times of microturbine (MGT) and heat storage system (HST) was set up by schedule timers. In 2008 the schedule timers were substituted to a new programmable logic controller (PLC) and the start times of MGT and HST were calculated as the function of temperature outside and room temperature. Setting the start time of MGT at maximum 5 hours before 8:00 and interlocking relays of HST on MGT, the start times were calculated from temperature outside and room temperature at 21:00 the day before. Control of start time using PLC was demonstrated from Feb. 21, 2009 to June 1 and from Nov. 16 to Jan. 7, 2010. It is shown the time series data of temperature and analysis of the CHP with the original boiler heating system.
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Tong, Timothy, Mohsen Abou-Ellail, Yuan Li, and Karam R. Beshay. "Numerical Computation of Reacting Flow in Porous Burners With an Extended CH4-Air Reaction Mechanism." In ASME 2004 Heat Transfer/Fluids Engineering Summer Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/ht-fed2004-56012.

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The present paper presents, numerical computations for flow, heat transfer and chemical reactions in an axisymmetric inert porous burner. The porous media re-radiate the heat absorbed from the gaseous combustion products by convection and conduction. In the present work, the porous burner species mass fraction source terms are computed from an ‘extended’ reaction mechanism, controlled by chemical kinetics of elementary reactions. The porous burner has mingled zones of porous/nonporous reacting flow, i.e. the porosity is not uniform over the entire domain. Therefore, it has to be included inside the partial derivatives of the transport governing equations. Finite-difference equations are obtained by formal integration over control volumes surrounding each grid node. Up-wind differencing is used to insure that the influence coefficients are always positive to reflect the real effect of neighboring nodes on a typical central node. Finite-difference equations are solved, iteratively, for U, V, p’ (pressure correction), enthalpy and species mass fractions, utilizing a grid of (60×40) nodes. The sixty grid nodes in the axial direction are needed to resolve the detailed structure of the thin reaction zone inside the porous media. The porous burner uses a premixed CH4-air mixture, while its radiating characteristics are computed numerically, using a four-flux radiation model. Sixteen species are included, namely CH4, CH3, CH2, CH, CH2O, CHO, CO, CO2, O2, O, OH, H2, H, H2O, HO2, H2O2, involving 49 chemical reaction equations. It was found that 900 iterations are sufficient for complete conversion of the computed results with errors less than 0.1%. The computed temperature profiles of the gas and the solid show that, heat is conducted from downstream to the upstream of the reaction zone. Most stable species, such as H2O, CO2, H2, keep increasing inside the reaction zone staying appreciable in the combustion products. However, unstable products, such as HO2, H2O2 and CH3, first increase in the preheating region of the reaction zone, they are then consumed fast in the post-reaction zone of the porous burner. Therefore, it appears that their important function is only to help the chemical reactions continue to their inevitable completion of the more stable combustion products.
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Czerwinski, Mary, Desney Tan, Arnie Lund, and Ben Shneiderman. "CHI 2008 Preview." In the SIGCHI Conference. New York, New York, USA: ACM Press, 2007. http://dx.doi.org/10.1145/1240624.2181002.

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Wixon, Dennis, Mary Beth Rosson, and David Gilmore. "CHI 2007 Welcome." In the SIGCHI Conference. New York, New York, USA: ACM Press, 2007. http://dx.doi.org/10.1145/1240624.2181033.

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Tyrell, David, David Jeong, Karina Jacobsen, and Eloy Martinez. "Improved Tank Car Safety Research." In ASME 2007 Rail Transportation Division Fall Technical Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/rtdf2007-46013.

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Three recent accidents involving the release of hazardous material have focused attention on the structural integrity of railroad tank cars: (1) Minot, ND, on January 18, 2002; (2) Macdona, TX, on June 28, 2004; and (3) Graniteville, SC, on January 6, 2005. Each of these accidents resulted in fatalities. Research is being conducted to develop strategies for improving railroad tank cars so they can maintain tank integrity in severe accidents. A collaborative effort called the Next Generation Rail Tank Car (NGRTC) Project intends to use these research results to help develop improved tank car designs. Dow Chemical Company, Union Pacific Railroad, and Union Tank Car Company are the industry sponsors of the NGRTC Project. The Federal Railroad Administration (FRA) and Transport Canada participate in the NGRTC project through Memoranda of Cooperation. FRA and the Pipeline and Hazardous Materials Safety Administration intend to use these research results to support rulemaking. The approach taken in performing this research is to define the collision conditions of concern, to evaluate the behavior of current design equipment in these scenarios, and to develop alternative strategies for increasing the maximum impact speed for which tank integrity is maintained. The accident scenarios have been developed from a review of accidents and are intended to bound the range of main-line accidents that can lead to a release of hazardous material from a tank car. The accident scenarios and collision modes have been used to define car-to-car impact scenarios. These car-to-car impact scenarios define the conditions under which the commodity must be contained. The impact scenarios are being used to evaluate the integrity of current design and improved design tank cars. Full-scale impact tests are also being conducted, to help validate modeling of the baseline equipment. The models have been refined based on the test results. The models are now being applied to develop the improved equipment designs. This paper describes the overall research framework and provides an overview of the research done to date, as well as the planned efforts.
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Watkins, Robert W., Bradley M. Loftin, and Don S. Hoang. "Authorizing the DOT Specification 6M Packaging for Continued Use at the Savannah River Site." In ASME 2010 Pressure Vessels and Piping Division/K-PVP Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/pvp2010-25437.

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The U.S. Department of Transportation (DOT) Specification 6M packaging was in extensive use for more than 40 years for in-commerce shipments of Type B quantities of fissile and radioactive material (RAM) across the USA, among the Department of Energy (DOE) laboratories, and between facilities in the DOE production complex. In January 2004, the DOT Research and Special Programs Administration (RSPA) Agency issued a final rule in the Federal Register to amend requirements in the Hazardous Materials Regulations (HMR) pertaining to the transportation of radioactive materials. The final rule became effective on October 1, 2004. One of those changes discontinued the use of the DOT specification 6M, along with other DOT specification packagings, on October 1, 2008. A main driver for the change was due to the fact that 6M specification packagings were not supported by a Safety Analysis Report for Packagings (SARP) that was compliant with Title 10 of the Code of Federal Regulations (CFR) Part 71 (10 CFR 71). The regulatory rules for the discontinued use have been edited in Title 49 of the Code of Federal Regulations (CFR) Parts 100 – 185, 2004 Edition and thereafter. Prior to October 1, 2008, the use of the 6M within the boundaries of the Savannah River Site (SRS), called an onsite transfer, was governed by an onsite transportation document that referenced 49 CFR Parts 100 – 185. SRS had to develop an Onsite Safety Assessment (OSA) which was independent of 49 CFR in order to justify the continued use of the DOT Specification 6M for the transfer of radioactive material (RAM) at the SRS after October 1, 2008. This paper will discuss the methodology for and difficulties associated with authorizing the DOT Specification 6M Packaging for continued use at the Savannah River Site.
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Reports on the topic "CHR 2002"

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Prussin, S., D. Slaughter, J. Pruet, M. Descalle, A. Bernstein, J. Hall, M. Accatino, et al. Nuclear car wash status report, August 2005. Office of Scientific and Technical Information (OSTI), July 2005. http://dx.doi.org/10.2172/877756.

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Chapman, Ray, Phu Luong, Sung-Chan Kim, and Earl Hayter. Development of three-dimensional wetting and drying algorithm for the Geophysical Scale Transport Multi-Block Hydrodynamic Sediment and Water Quality Transport Modeling System (GSMB). Engineer Research and Development Center (U.S.), July 2021. http://dx.doi.org/10.21079/11681/41085.

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The Environmental Laboratory (EL) and the Coastal and Hydraulics Laboratory (CHL) have jointly completed a number of large-scale hydrodynamic, sediment and water quality transport studies. EL and CHL have successfully executed these studies utilizing the Geophysical Scale Transport Modeling System (GSMB). The model framework of GSMB is composed of multiple process models as shown in Figure 1. Figure 1 shows that the United States Army Corps of Engineers (USACE) accepted wave, hydrodynamic, sediment and water quality transport models are directly and indirectly linked within the GSMB framework. The components of GSMB are the two-dimensional (2D) deep-water wave action model (WAM) (Komen et al. 1994, Jensen et al. 2012), data from meteorological model (MET) (e.g., Saha et al. 2010 - http://journals.ametsoc.org/doi/pdf/10.1175/2010BAMS3001.1), shallow water wave models (STWAVE) (Smith et al. 1999), Coastal Modeling System wave (CMS-WAVE) (Lin et al. 2008), the large-scale, unstructured two-dimensional Advanced Circulation (2D ADCIRC) hydrodynamic model (http://www.adcirc.org), and the regional scale models, Curvilinear Hydrodynamics in three dimensions-Multi-Block (CH3D-MB) (Luong and Chapman 2009), which is the multi-block (MB) version of Curvilinear Hydrodynamics in three-dimensions-Waterways Experiments Station (CH3D-WES) (Chapman et al. 1996, Chapman et al. 2009), MB CH3D-SEDZLJ sediment transport model (Hayter et al. 2012), and CE-QUAL Management - ICM water quality model (Bunch et al. 2003, Cerco and Cole 1994). Task 1 of the DOER project, “Modeling Transport in Wetting/Drying and Vegetated Regions,” is to implement and test three-dimensional (3D) wetting and drying (W/D) within GSMB. This technical note describes the methods and results of Task 1. The original W/D routines were restricted to a single vertical layer or depth-averaged simulations. In order to retain the required 3D or multi-layer capability of MB-CH3D, a multi-block version with variable block layers was developed (Chapman and Luong 2009). This approach requires a combination of grid decomposition, MB, and Message Passing Interface (MPI) communication (Snir et al. 1998). The MB single layer W/D has demonstrated itself as an effective tool in hyper-tide environments, such as Cook Inlet, Alaska (Hayter et al. 2012). The code modifications, implementation, and testing of a fully 3D W/D are described in the following sections of this technical note.
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EVANS, C. B. Implementation Evaluation Criteria for January 2001 Amended 10 CFR Part 830 Nuclear Safety Management. Office of Scientific and Technical Information (OSTI), February 2001. http://dx.doi.org/10.2172/806002.

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Bayless, Paul David. RELAP5/MOD3.2 Assessment Using CHF Data from the KS-1 and V-200 Experiment Facilities. Office of Scientific and Technical Information (OSTI), July 2001. http://dx.doi.org/10.2172/910685.

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SIngh, M. Freedom car and vehicle technologies heavy vehicle program : FY 2007 benefits analysis, methodology and results -- final report. Office of Scientific and Technical Information (OSTI), February 2008. http://dx.doi.org/10.2172/925390.

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Birt, Brenna, Rachael Boothe, Genevieve Braus, Theodore Devito, Larry Durbin, John Eickhoff, Eryn Lussier, Tom Ryon, Kurt Schlomberg, and Eric Schmitz. Environmental Performance Report 2020: Annual Site Environmental Report per the U.S. Department of Energy Order 231.1B Chg 1. Office of Scientific and Technical Information (OSTI), August 2021. http://dx.doi.org/10.2172/1814599.

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Torres, Marissa, Norberto Nadal-Caraballo, and Alexandros Taflanidis. Rapid tidal reconstruction for the Coastal Hazards System and StormSim part II : Puerto Rico and U.S. Virgin Islands. Engineer Research and Development Center (U.S.), August 2021. http://dx.doi.org/10.21079/11681/41482.

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This Coastal and Hydraulics Engineering Technical Note (CHETN) describes the continuing efforts towards incorporating rapid tidal time-series reconstruction and prediction capabilities into the Coastal Hazards System (CHS) and the Stochastic Storm Simulation System (StormSim). The CHS (Nadal-Caraballo et al. 2020) is a national effort for the quantification of coastal storm hazards, including a database and web tool (https://chs.erdc.dren.mil) for the deployment of results from the Probabilistic Coastal Hazard Analysis (PCHA) framework. These PCHA products are developed from regional studies such as the North Atlantic Coast Comprehensive Study (NACCS) (Nadal-Caraballo et al. 2015; Cialone et al. 2015) and the ongoing South Atlantic Coast Study (SACS). The PCHA framework considers hazards due to both tropical and extratropical cyclones, depending on the storm climatology of the region of interest. The CHS supports feasibility studies, probabilistic design of coastal structures, and flood risk management for coastal communities and critical infrastructure. StormSim (https://stormsim.erdc.dren.mil) is a suite of tools used for statistical analysis and probabilistic modeling of historical and synthetic storms and for stochastic design and other engineering applications. One of these tools, the Coastal Hazards Rapid Prediction System (CHRPS) (Torres et al. 2020), can perform rapid prediction of coastal storm hazards, including real-time hurricane-induced flooding. This CHETN discusses the quantification and validation of the Advanced Circulation (ADCIRC) tidal constituent database (Szpilka et al. 2016) and the tidal reconstruction program Unified Tidal analysis (UTide) (Codiga 2011) in the Puerto Rico and U.S. Virgin Islands (PR/USVI) coastal regions. The new methodology discussed herein will be further developed into the Rapid Tidal Reconstruction (RTR) tool within the StormSim and CHS frameworks.
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David Allen, Paul Clay. U. S. Department of Energy Air Emissions Annual Report 40 Code of Federal Regulations (CFR) 61.94, Subpart H Calendar Year 2007 - DE-AC05-98OR22700: Calendar Year 2007 Oak Ridge Reservation Air Emissions Annual Report Certification. Office of Scientific and Technical Information (OSTI), June 2008. http://dx.doi.org/10.2172/972798.

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Kaboré, Gisele, and Idrissa Kabore. Analyse secondaire des données de l'analyse situationnelle des services de santé de la reproduction. Population Council, 2009. http://dx.doi.org/10.31899/pgy20.1000.

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En début 2002, l’UNFPA a soutenu un projet intitulé Renforcement des services sanitaires et sociaux pour faire face aux besoins de santé sexuelle et reproductive des adolescentes. Le projet avait pour objectif d’améliorer la connaissance des adolescentes mariées en ce qui concerne la législation et leurs propres droits; les éduquer à prendre soin de leur propre santé et de celle de leurs enfants; et augmenter leur accessibilité aux services de santé reproductive, particulièrement dans les régions les plus pauvres du Burkina Faso. Le projet a affirmé que les normes de fonctionnement ne sont pas remplies en termes d’infrastructures, d’équipement, de matériel et de ressources humaines. Les services disponibles ne sont pas bien connus par les populations, ce qui peut limiter la fréquentation. Il apparaît aussi que les services offerts aux adolescents ne sont pas assez développés car peu de prestataires ont des compétences nécessaires. Quelques recommandations ont été formulées en réponses aux problèmes et aux insuffisances constatées, sur la capacité d’offre et la qualité des services.
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Brown, Anne, Alice Grossman, and Lucy Noble. Via2G Microtransit Pilot Evaluation. Mineta Transportation Institute, May 2021. http://dx.doi.org/10.31979/mti.2021.2002.

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Google partnered with Via to launch an on-demand microtransit called Via2G between January and March 2020. The pilot provided employees with free travel to/from two of its offices in suburban, congested Silicon Valley. While the pilot was cut short due to COVID-19, rider participation grew steadily during operation. Of trip requests, 8,636 (87.8%) resulted in a ride offer. Unfulfilled requests were primarily outside of pilot operating times or when rider demand exceeded driver supply. Most users (72%) completed at least two trips, although recurring users were less likely to complete errands on the commute and fewer had a car available for commuting compared to all surveyed Google employees. Prior to Via2G, two-thirds (66%) of survey respondents drove to work at least one day per week, while a plurality (42%) drove five days per week. Compared to non-participants, pilot users were more likely to take ride-hail (14 vs 22 percent) or the Google Bus (24 vs 30 percent) at least once a week prior to the pilot. Recommendations suggest iterations for Google or other centralized employers to consider in future microtransit programs.
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