Academic literature on the topic 'Chromatin'

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Journal articles on the topic "Chromatin"

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Mishra, Prashant K., Sultan Ciftci-Yilmaz, David Reynolds, et al. "Polo kinase Cdc5 associates with centromeres to facilitate the removal of centromeric cohesin during mitosis." Molecular Biology of the Cell 27, no. 14 (2016): 2286–300. http://dx.doi.org/10.1091/mbc.e16-01-0004.

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Sister chromatid cohesion is essential for tension-sensing mechanisms that monitor bipolar attachment of replicated chromatids in metaphase. Cohesion is mediated by the association of cohesins along the length of sister chromatid arms. In contrast, centromeric cohesin generates intrastrand cohesion and sister centromeres, while highly cohesin enriched, are separated by >800 nm at metaphase in yeast. Removal of cohesin is necessary for sister chromatid separation during anaphase, and this is regulated by evolutionarily conserved polo-like kinase (Cdc5 in yeast, Plk1 in humans). Here we addre
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Daban, Joan-Ramon. "The energy components of stacked chromatin layers explain the morphology, dimensions and mechanical properties of metaphase chromosomes." Journal of The Royal Society Interface 11, no. 92 (2014): 20131043. http://dx.doi.org/10.1098/rsif.2013.1043.

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The measurement of the dimensions of metaphase chromosomes in different animal and plant karyotypes prepared in different laboratories indicates that chromatids have a great variety of sizes which are dependent on the amount of DNA that they contain. However, all chromatids are elongated cylinders that have relatively similar shape proportions (length to diameter ratio approx. 13). To explain this geometry, it is considered that chromosomes are self-organizing structures formed by stacked layers of planar chromatin and that the energy of nucleosome–nucleosome interactions between chromatin lay
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Chen, Yu-Fan, Chia-Ching Chou, and Marc R. Gartenberg. "Determinants of Sir2-Mediated, Silent Chromatin Cohesion." Molecular and Cellular Biology 36, no. 15 (2016): 2039–50. http://dx.doi.org/10.1128/mcb.00057-16.

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Cohesin associates with distinct sites on chromosomes to mediate sister chromatid cohesion. Single cohesin complexes are thought to bind by encircling both sister chromatids in a topological embrace. Transcriptionally repressed chromosomal domains in the yeastSaccharomyces cerevisiaerepresent specialized sites of cohesion where cohesin binds silent chromatin in a Sir2-dependent fashion. In this study, we investigated the molecular basis for Sir2-mediated cohesion. We identified a cluster of charged surface residues of Sir2, collectively termed the EKDK motif, that are required for cohesin func
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Giménez-Abián, J. F., D. J. Clarke, A. M. Mullinger, C. S. Downes, and R. T. Johnson. "A postprophase topoisomerase II-dependent chromatid core separation step in the formation of metaphase chromosomes." Journal of Cell Biology 131, no. 1 (1995): 7–17. http://dx.doi.org/10.1083/jcb.131.1.7.

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Metaphase chromatids are believed to consist of loops of chromatin anchored to a central scaffold, of which a major component is the decatenatory enzyme DNA topoisomerase II. Silver impregnation selectively stains an axial element of metaphase and anaphase chromatids; but we find that in earlier stages of mitosis, silver staining reveals an initially single, folded midline structure, which separates at prometaphase to form two chromatid axes. Inhibition of topoisomerase II prevents this separation, and also prevents the contraction of chromatids that occurs when metaphase is arrested. Immunolo
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Muñoz, Sofía, Francesca Passarelli, and Frank Uhlmann. "Conserved roles of chromatin remodellers in cohesin loading onto chromatin." Current Genetics 66, no. 5 (2020): 951–56. http://dx.doi.org/10.1007/s00294-020-01075-x.

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Abstract Cohesin is a conserved, ring-shaped protein complex that topologically entraps DNA. This ability makes this member of the structural maintenance of chromosomes (SMC) complex family a central hub of chromosome dynamics regulation. Besides its essential role in sister chromatid cohesion, cohesin shapes the interphase chromatin domain architecture and plays important roles in transcriptional regulation and DNA repair. Cohesin is loaded onto chromosomes at centromeres, at the promoters of highly expressed genes, as well as at DNA replication forks and sites of DNA damage. However, the fea
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Stephens, Andrew D., Julian Haase, Leandra Vicci, Russell M. Taylor, and Kerry Bloom. "Cohesin, condensin, and the intramolecular centromere loop together generate the mitotic chromatin spring." Journal of Cell Biology 193, no. 7 (2011): 1167–80. http://dx.doi.org/10.1083/jcb.201103138.

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Sister chromatid cohesion provides the mechanistic basis, together with spindle microtubules, for generating tension between bioriented chromosomes in metaphase. Pericentric chromatin forms an intramolecular loop that protrudes bidirectionally from the sister chromatid axis. The centromere lies on the surface of the chromosome at the apex of each loop. The cohesin and condensin structural maintenance of chromosomes (SMC) protein complexes are concentrated within the pericentric chromatin, but whether they contribute to tension-generating mechanisms is not known. To understand how pericentric c
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Lawrimore, Josh, Ayush Doshi, Brandon Friedman, Elaine Yeh, and Kerry Bloom. "Geometric partitioning of cohesin and condensin is a consequence of chromatin loops." Molecular Biology of the Cell 29, no. 22 (2018): 2737–50. http://dx.doi.org/10.1091/mbc.e18-02-0131.

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SMC (structural maintenance of chromosomes) complexes condensin and cohesin are crucial for proper chromosome organization. Condensin has been reported to be a mechanochemical motor capable of forming chromatin loops, while cohesin passively diffuses along chromatin to tether sister chromatids. In budding yeast, the pericentric region is enriched in both condensin and cohesin. As in higher-eukaryotic chromosomes, condensin is localized to the axial chromatin of the pericentric region, while cohesin is enriched in the radial chromatin. Thus, the pericentric region serves as an ideal model for d
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Ghaddar, Nagham, Pierre Luciano, Vincent Géli, and Yves Corda. "Chromatin assembly factor-1 preserves genome stability in ctf4∆ cells by promoting sister chromatid cohesion." Cell Stress 7, no. 9 (2023): 69–89. http://dx.doi.org/10.15698/cst2023.09.289.

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Chromatin assembly and the establishment of sister chromatid cohesion are intimately connected to the progression of DNA replication forks. Here we examined the genetic interaction between the heterotrimeric chromatin assembly factor-1 (CAF-1), a central component of chromatin assembly during replication, and the core replisome component Ctf4. We find that CAF-1 deficient cells as well as cells affected in newly-synthesized H3-H4 histones deposition during DNA replication exhibit a severe negative growth with ctf4∆ mutant. We dissected the role of CAF-1 in the maintenance of genome stability i
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SIMPSON, R. T. "Chromatin Research Surveyed: Chromatin." Science 243, no. 4895 (1989): 1220. http://dx.doi.org/10.1126/science.243.4895.1220.

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Stanyte, Rugile, Johannes Nuebler, Claudia Blaukopf, et al. "Dynamics of sister chromatid resolution during cell cycle progression." Journal of Cell Biology 217, no. 6 (2018): 1985–2004. http://dx.doi.org/10.1083/jcb.201801157.

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Faithful genome transmission in dividing cells requires that the two copies of each chromosome’s DNA package into separate but physically linked sister chromatids. The linkage between sister chromatids is mediated by cohesin, yet where sister chromatids are linked and how they resolve during cell cycle progression has remained unclear. In this study, we investigated sister chromatid organization in live human cells using dCas9-mEGFP labeling of endogenous genomic loci. We detected substantial sister locus separation during G2 phase irrespective of the proximity to cohesin enrichment sites. Alm
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Dissertations / Theses on the topic "Chromatin"

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Jurisic, Anamarija. "Développement d'une approche méthodologique basée sur la biotinylation in vivo de protéines de la chromatine - Application à l’étude des interactions entre des domaines chromosomiques et une protéine de l'enveloppe nucléaire dans des cellules individuelles." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS349.

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Les arguments en faveur d’un rôle important de l'architecture des chromosomes en interphase pour la régulation des gènes et la maintenance du génome s’accumulent rapidement. Au cours de l'interphase, les chromosomes sont positionnés de façon non aléatoire l’un par rapport à l'autre et fournissent ainsi des points de repère nucléaires. Deux types d'interactions contribuent probablement à ce positionnement non aléatoire: (i) des domaines subchromosomiques interagissent avec des structures nucléaires telles l'enveloppe nucléaire (EN) et (ii) des interactions intrachromosomiques s’établissent entr
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Gasser, Regula. "Active chromatin /." [S.l.] : [s.n.], 1993. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10389.

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Belaghzal, Houda. "Chromatin Interaction Dynamics Revealed by Liquid Chromatin Hi-C." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1046.

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Development and application of genomic approaches based on 3C methods combined with increasingly powerful imaging approaches have enabled high-resolution genome-wide analysis of the spatial organization of chromosomes in genome function. In this thesis, I first describe an updated protocol for Hi-C (Hi-C 2.0), integrating recent improvements that significantly contribute to the efficient and high-resolution capture of chromatin interactions. Secondly, I present an assessment of the epigenetic landscape and chromosome conformation around the MYC gene in acute myeloid leukemia (AML) cells before
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Besnard, Emilie. "Modifications de l'organisation de la chromatine liées à l’entrée en sénescence et son impact sur la réplication du génome." Thesis, Montpellier 1, 2010. http://www.theses.fr/2010MON1T008.

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L'entrée en sénescence, considérée comme un arrêt irréversible du cycle, se caractérise par une modification de l'organisation de la chromatine formant de véritables foyers d' hétérochromatine spécifiques (SAHF) coordonnée à une modification d'expression génique et à un déclin progressif de la compétence à répliquer le génome. Ainsi, au cours de ma thèse, j'ai voulu comprendre en quoi ces changements d'organisation du génome pouvaient influer sur la distribution et l'activation des origines d e réplication lors de l'entrée en sénescence réplicative ou déclenchée de façon prématurée par l'inhib
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Clynes, David Alexander. "Signalling to chromatin." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496840.

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Jang, Boyun. "Analysis of chromatin targeting modules in the chromatin remodelling enzyme NURF." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5204/.

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Drosophila nucleosome remodelling factor (NURF) is one of the founding members of the ISWI family of ATP-dependent chromatin remodelling enzymes and mediates energy-dependent nucleosome sliding leading to transcription regulation. In previous work (Wysocka et al., 2006), NURF was shown to be recruited to gene targets by binding specific histone modifications. The largest subunit of NURF, NURF301, contains a bromodomain and three PHD finger domains that have the ability to recognize specific histone modifications. Here we determine the histone binding-specificities of these domains, and how NUR
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Marie, Corentine. "The role of Chd7 & Chd8 chromatin remodelers in oligodendrogenesis and (re)myelination." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066365/document.

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Les oligodendrocytes (OLs) sont les cellules myélinisantes du système nerveux central, s’enroulant autour des axones et permettant la conduction saltatoire du potentiel d’action. Dans la Sclérose en Plaques, des gaines de myélines sont détruites et l’efficacité de la remyélinisation par les précurseurs d’oligodendrocytes (OPCs) diminue avec la progression de la maladie. Une meilleure compréhension du mécanisme qui contrôle la génération des OPCs et leur différentiation est donc essentielle pour développer des thérapies efficaces de remyélinisation. L’oligodendrogenèse, qui comprend les étapes
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Beurton, Flore. "Étude de l’interaction physique et fonctionnelle entre le complexe histone méthyltransférase SET-2/SET1 et le complexe histone déacétylase SIN-3S dans l’embryon de C. elegans." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEN017.

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Les complexes histones méthyltransférases SET1, hautement conservés de la levure aux mammifères, sont ciblés aux régions promotrices par la protéine CFP1/CXXC, résultant en l’implémentation de la méthylation de la lysine 4 de l’histone H3 (H3K4me), modification post-traductionnelle influençant l’expression des gènes selon le contexte chromatinien. La présence de plusieurs complexes SET1 distincts dans différents systèmes modèles eucaryotes a compliqué l’étude de leurs fonctions dans un contexte développemental. Caenorhabditis elegans contient une seule protéine homologue de SET1, SET-2, et d’u
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Nothjunge, Stephan [Verfasser], and Stefan [Akademischer Betreuer] Günther. "Chromatin-Interaktionen in Kardiomyozyten." Freiburg : Universität, 2019. http://d-nb.info/1185390979/34.

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Little, Gillian H. "Stat5 binding to chromatin." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/12435.

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Expression of milk proteins including β-lactoglobulin is controlled by prolactin activation of the transcription factor Stat5 via the Janus kinase/Signal transducer and activator of transcription (Jak/STAT) pathway. Stat5 has previously been shown to tetramerise where binding sites are tandemly linked and the proximity of these binding sites appears to be important for these interactions. This work and previous large scale mapping of the β-lactoglobulin promoter shows that the dyad of a strongly positioned nucleosome lies at -184 bp from the transcription start on the promoter of the β-lactogl
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Books on the topic "Chromatin"

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David, Allis C., and Wu Carl, eds. Chromatin and chromatin remodeling enzymes. Elsevier/Academic Press, 2004.

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Horsfield, Julia, and Judith Marsman, eds. Chromatin. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2140-0.

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van Holde, Kensal E. Chromatin. Springer New York, 1989. http://dx.doi.org/10.1007/978-1-4612-3490-6.

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David, Allis C., and Wu Carl, eds. Chromatin and chromatin remodeling enzymes. Elsevier Academic Press, 2004.

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1942-, Gualerzi Claudio O., Pon Cynthia L. 1942-, and Symposium "Selected Topics on Chromatin Structure and Function" (1985 : University of Camerino), eds. Bacterial chromatin. Springer-Verlag, 1986.

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Becker, Peter B. Chromatin Protocols. Humana Press, 1999. http://dx.doi.org/10.1385/1592596819.

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Chellappan, Srikumar P., ed. Chromatin Protocols. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2474-5.

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Zini, Armand, and Ashok Agarwal, eds. Sperm Chromatin. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6857-9.

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Gualerzi, Claudio O., and Cynthia L. Pon, eds. Bacterial Chromatin. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71266-1.

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Morse, Randall H., ed. Chromatin Remodeling. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-477-3.

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Book chapters on the topic "Chromatin"

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Carlberg, Carsten, and Ferdinand Molnár. "Chromatin." In Human Epigenetics: How Science Works. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-22907-8_2.

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Hoyer, Daniel, Eric P. Zorrilla, Pietro Cottone, et al. "Chromatin." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_743.

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Arnemann, J. "Chromatin." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_3449.

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Arnemann, J. "Chromatin." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_3449-1.

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Brahmachari, Vani, and Shruti Jain. "Chromatin." In Encyclopedia of Systems Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_845.

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Gooch, Jan W. "Chromatin." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13387.

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Dame, Remus T. "Ultrastructure and Organization of Bacterial Chromosomes." In Bacterial Chromatin. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-3473-1_1.

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Bell, Stephen D., and Malcolm F. White. "Archaeal Chromatin Organization." In Bacterial Chromatin. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-3473-1_10.

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Travers, Andrew, and Georgi Muskhelishvili. "The Topology and Organization of Eukaryotic Chromatin." In Bacterial Chromatin. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-3473-1_11.

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Dorman, Charles J. "Bacterial Chromatin and Gene Regulation." In Bacterial Chromatin. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-3473-1_12.

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Conference papers on the topic "Chromatin"

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Keizer, Veer, Simon Grosse-Holz, Maxime Woringer, et al. "Magnetic micromanipulation of chromatin in live cells." In Optical Trapping and Optical Micromanipulation XXI, edited by Halina Rubinsztein-Dunlop, Kishan Dholakia, and Giovanni Volpe. SPIE, 2024. http://dx.doi.org/10.1117/12.3029469.

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Celms, Edgars, Lelde Lace, Gatis Melkus, et al. "Enhanced Graph Representations of Chromatin Interaction Networks." In 16th International Conference on Bioinformatics Models, Methods and Algorithms. SCITEPRESS - Science and Technology Publications, 2025. https://doi.org/10.5220/0013173100003911.

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Wang, Geng, Ruyi Gong, Nicolas Acosta, et al. "Nanoscale multimodal imaging platform for chromatin study (Conference Presentation)." In Multimodal Biomedical Imaging XX, edited by Xavier Intes, Marien Ochoa, and Mohammad A. Yaseen. SPIE, 2025. https://doi.org/10.1117/12.3042540.

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Wang, Geng, Ruyi Gong, Yuanzhe Su, et al. "Label-free DNA spectroscopic photon-localization nanoscopy." In Novel Techniques in Microscopy. Optica Publishing Group, 2025. https://doi.org/10.1364/ntm.2025.nm1c.5.

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We present Label-free DNA Spectroscopic Photon-Localization Nanoscopy, an intrinsic-contrast 3D genomic imaging technology with nanometer resolution, leveraging DNA autofluorescence and spectral algorithms to resolve chromatin types, map genomic domains, and reconstruct 3D genome structures.
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Adenot, P. G., M. Gèze, P. Debey, and M. S. Szöllösi. "Chromatin ‘‘in real time’’." In The living cell in four dimensions. AIP, 1991. http://dx.doi.org/10.1063/1.40579.

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Emmett, Kevin, Benjamin Schweinhart, and Raul Rabadan. "Multiscale Topology of Chromatin Folding." In 9th EAI International Conference on Bio-inspired Information and Communications Technologies (formerly BIONETICS). ACM, 2016. http://dx.doi.org/10.4108/eai.3-12-2015.2262453.

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Zhong, Jian, Zhenqing Ye, Chad Clark, et al. "Abstract 5180: Enhanced and controlled chromatin extraction for chromatin-based epigenetic assays in FFPE tissues." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-5180.

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Zhong, Jian, Zhenqing Ye, Chad Clark, et al. "Abstract 5180: Enhanced and controlled chromatin extraction for chromatin-based epigenetic assays in FFPE tissues." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-5180.

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Iashina, E. G., E. Yu Varfolomeeva, R. A. Pantina, et al. "MODEL OF CHROMATIN ORGANIZATION IN BIOLOGICAL CELL NUCLEI BASED ON SANS AND SAXS DATA." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-172.

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Summarizing the results of SAS on biological cell nuclei and the success of describing transcriptionally inactive (closed) chromatin by the fractal globule model, we propose a bifractal model of the structure of the nucleus, according to which a system of transport channels (logarithmic fractal) is located inside the densely packed closed chromatin, and active chromatin is localized near or inside the transport channels and forms volumetric fractal structures.
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Kudrin, Roman, and Andrey Mironov. "Inferring chromatin states with stochastic autoencoder." In 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2018. http://dx.doi.org/10.1109/bibm.2018.8621155.

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Reports on the topic "Chromatin"

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Kun, Ernest. Molecular Toxicology of Chromatin. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada247307.

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Jeans, C., M. Thelen, and A. Noy. Single Molecule Studies of Chromatin. Office of Scientific and Technical Information (OSTI), 2006. http://dx.doi.org/10.2172/877892.

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Pandita, Tej K. Chromatin Structure and Breast Cancer Radiosensitivity. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada434814.

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Pandita, Tej K. Chromatin Structure and Breast Cancer Radiosensitivity. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada588290.

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Pandita, Tej K. Chromatin Structure and Breast Cancer Radiosensitivity. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada423679.

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Bradbury, E. M. Neutron scatter studies of chromatin structures related to functions. Office of Scientific and Technical Information (OSTI), 1991. http://dx.doi.org/10.2172/6000035.

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Bradbury, E. M. Neutron scatter studies of chromatin structures related to functions. Office of Scientific and Technical Information (OSTI), 1992. http://dx.doi.org/10.2172/7224363.

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Bradbury, E. M. Neutron scatter studies of chromatin structures related to functions. Office of Scientific and Technical Information (OSTI), 1992. http://dx.doi.org/10.2172/5312037.

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Nordeen, Steven. Classical and Nonclassical Estrogen Receptor Action on Chromatin Templates. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada382501.

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Bradbury, E. M. Neutron scatter studies of chromatin structure related to functions. Office of Scientific and Technical Information (OSTI), 1989. http://dx.doi.org/10.2172/5445330.

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