Dissertations / Theses on the topic 'Chromatin Assembly'
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Jansen, Hailey Janice. "Characterization of chromatin assembly in murine embryos." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44768.
Full textDunleavy, Elaine. "Assembly of centromeric chromatin in fission yeast." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/13739.
Full textKats, Ellen Simona. "De-caf-einated life without chromatin assembly factors /." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3221182.
Full textTitle from first page of PDF file (viewed September 8, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
Royle, Nikki. "Expression, purification and characterisation of recombinant chromatin assembly factor 1." Thesis, University of Cambridge, 2013. https://www.repository.cam.ac.uk/handle/1810/244243.
Full textRasala, Beth A. "Defining the early steps in nuclear pore assembly chromatin-associated ELYS initiates pore assembly /." Diss., View abstract only; access to full text of dissertation for UC IP will be available after 1/1/2011, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3296834.
Full textTitle from first page of PDF file (viewed June 3, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
Pietrobon, Violena. "Chromatin assembly by CAF-1 during homologous recombination : a novel step of regulation." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00977568.
Full textNabatiyan, Arman. "The role of chromatin assembly factor-1 in human cells." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615283.
Full textWong, Hiu-ting. "A role of TSPYL2, a novel nucleosome assembly protein, in transcriptional regulation." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43085726.
Full textHuanyu, Wang. "Characterization of N1/N2 Family Histone Chaperones: Hif1p and NASP." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1279815431.
Full textHunt, Spencer Philip. "Whole-Genome Assembly of Atriplex hortensis L. Using OxfordNanopore Technology with Chromatin-Contact Mapping." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8580.
Full textWong, Hiu-ting, and 王曉婷. "A role of TSPYL2, a novel nucleosome assembly protein, in transcriptional regulation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085726.
Full textTopal, Salih. "Chromatin Dynamics Regulate Transcriptional Homeostasis." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1062.
Full textHaddad, John. "Structural and Biochemical Insights into the Assembly of the DPY-30/Ash2L Heterotrimer." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36616.
Full textAi, Xi. "Biochemical characterization of a hat1p-containing histone acetyltransferase complex." Columbus, Ohio : Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1085509452.
Full textTitle from first page of PDF file. Document formatted into pages; contains xv1, 151 p.; also includes graphics. Includes abstract and vita. Advisor: Mark Parthun, Dept. of Biochemistry. Includes bibliographical references (p. 138-151).
English, Christine Marie. "Insights into chromatin assembly through the characterization of the histone chaperone ASF1 bound to histones H3-H4 /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2006.
Find full textTypescript. Includes bibliographical references (leaves 169-185). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;
Aguilar, Gurrieri Carmen. "Etudes structurales sur l'assemblage du nucléosome." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV017/document.
Full textAssembly of chromatin is an essential process that concerns most DNA transactions in eukaryotic cells. The basic repeating unit of chromatin are nucleosomes, macromolecular complexes that consist of a histone octamer that organizes 147 bp of DNA in two superhelical turns. Although, the structures of nucleosomes are known in detail, their assembly is poorly understood. In vivo, nucleosome assembly is orchestrated by ATP-dependent remodelling enzymes, histone-modifying enzymes and a number of at least partially redundant histone chaperones. Histone chaperons are a structurally diverse class of proteins that direct the productive assembly and disassembly of nucleosomes by facilitating histone deposition and exchange. The currently accepted model is that nucleosome assembly is a sequential process that begins with the interaction of H3/H4 with DNA to form a (H3/H4)2 tetramer-DNA complex. The addition of two H2A/H2B dimers completes a canonical nucleosome. High-resolution structures of histone chaperons in complex with H3/H4 histones have resulted in detailed insights into the process of nucleosome assembly. However, our understanding of the mechanism of nucleosome assembly has been hampered by the as yet limited number of co-crystal structures of histone–chaperone complexes. In particular it remains unclear how histone chaperons mediate H2A/H2B deposition to complete nucleosome assembly. In this work, we have investigated the role of the H2A/H2B chaperon Nap1 (Nucleosome assembly protein 1) in nucleosome assembly. We have determined the crystal structure of the complex between Nap1 and H2A/H2B and analysed the assembly by various biophysical methods. The structure shows that a Nap1 dimer binds to one copy of H2A/H2B (Nap1_2-H2A/H2B). A large ~550 kDa macromolecular assembly containing 6 copies of the Nap12-H2A/H2B complex is seen in the asymmetric crystallographic unit. We confirmed by both non-denaturing mass spectroscopy and negative stain electron microscopy studies that this assembly is the predominant form of the Nap1_2-H2A/H2B complex in solution. We further investigated the potential interplay between p300-mediated histone acetylation and nucleosome assembly. Together, the structure and associated functional analysis provide a detailed mechanism for the Nap1 chaperon activity, its role in H2A/H2B deposition and in nucleosome assembly
Keenen, Bridget A. "The role of SWI/SNF chromatin remodeling enzymes in melanoma." Toledo, Ohio : University of Toledo, 2010. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1271819328.
Full text"Submitted to the Graduate Faculty as partial fulfillment of the requirements for the Doctor of Philosophy Degree in Biomedical Sciences." Title from title page of PDF document. "A Dissertation entitled"--at head of title. Bibliography: p. 63-71, 126-140.
Rodriges, Blanko Elena V. "ANALYSIS OF HUMAN DNA MISMATCH REPAIR IN THE CHROMATIN ENVIRONMENT." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/dissertations/967.
Full textWalfridsson, Julian. "The CHD chromatin remodeling factors in schizosaccharomyces pombe /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-106-7/.
Full textBennett, Gwendolyn M. "Chromatin Regulators and DNA Repair: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/742.
Full textBennett, Gwendolyn M. "Chromatin Regulators and DNA Repair: A Dissertation." eScholarship@UMMS, 2012. http://escholarship.umassmed.edu/gsbs_diss/742.
Full textGe, Zhongqi. "Role of Nuclear Hat1p Complex and Acetylation of Newly Synthesized Histone H4 in Chromatin Assembly." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1356622980.
Full textAgudelo, Garcia Paula A. "Identification of New Roles for Histone Acetyltransferase 1." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492599746298382.
Full textNguyen, Vu Quang. "Structural insights into the assembly and dynamics of the ATP-dependent chromatin-remodeling complex SWR1." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11606.
Full textLiu, Jessica Chishow. "Biochemical Characterization of the Domain Architecture of Chromatin Assembly Motor Proteins Human CHD1 and CHD2." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226060.
Full textKlapholz, Benjamin. "Le facteur d'assemblage de la chromatine CAF-1 : analyse fonctionnelle chez la drosophile." Paris 6, 2008. http://www.theses.fr/2008PA066322.
Full textPugieux, Céline. "Meiotic spindle assembly on chromatin micropatterns : investigating the roles of Augmin, Kinesin-10 and Kinesin-4." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ011.
Full textCell division is essential for the survival of every living organism. During this process, the chromosomes of the dividing cell are transmitted to the two daughter cells. The partition of the chromosomes is orchestrated by a transient sub-cellular structure called the mitotic spindle (or meiotic spindle in gamete cells). The spindle is composed of microtubules, numerous proteins and molecular motors, which interact in an intricate and yet precise manner leading to a highly dynamic and complexstructure. As some molecular mechanisms remain elusive, we have chosen to address the question of meiotic spindle assembly in Xenopus egg extracts. Xenopus laevis is a model system that is evolutionary close to human, and suitable for cell division studies. We have combined this with an in vitro assay - spindle array - which we developed prior to this work, and which provides advantages over existing approaches. A spindle array is composed of chromatin-coated beads that are immobilized according to geometrical patterns obtained by microcontact printing. The assembly of meiotic spindles wasvisualized by time-lapse fluorescence confocal microscopy. Using these tools, we first addressed the role of augmin in the assembly of meiotic spindles. Augmin is a recently identified protein complex that has been hypothesized to induce microtubule nucleation from the side of preexisting microtubules. By depleting augmin, we found that microtubule nucleationwas reduced and that spindles were morphologically impaired. Spindles were predominantly multipolar but finally reached bipolarity as a result of a newly uncovered augmin-independent microtubule nucleation pathway from acentrosomal poles. Our results thus reveal that augmin is essential for the proper establishment of the microtubule scaffolding and the bipolarity ofacentrosomal spindles. Secondly, we investigated the functions of the chromokinesins kinesin-4 (Xklp1) and kinesin-10 (Xkid)in acentrosomal spindle architecture and motions. Xkid plays a major role in the polar ejection forces leading chromosome movements during congression while the main function of XKlp1 is to regulate microtubule dynamics. We studied spindle assembly in depleted extracts and we report that Xkid limits the dynamics of spindle longitudinal movements, contributes to spindle bipolarity and affects spindle length while XKlp1 controls the spindle microtubule mass. Altogether these findings contribute to a better understanding of meiotic spindle assembly and confirm the pertinence of our method to study spindle morphogenesis
Garinther, Wendy Irene. "Studies of the topoisomerase and cofactor requirements for nucleosome reconstitution in a yeast chromatin assembly system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/mq22598.pdf.
Full textMocavini, Ivano 1991. "Variations of Polycomb assembly in mouse embryonic stem cells and early differentiation." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2022. http://hdl.handle.net/10803/673953.
Full textLos complejos de represión Polycomb (PRC)1 y 2 juegan un papel central en la regulación de la expresión génica, preservando la memoria epigenética del estado de silenciamiento. El uso de células madre embrionarias de ratón (mESCs) como modelo para el estudio de los complejos Polycomb, ha permitido la identificación de muchos factores accesorios. Sin embargo, no se conocen los mecanismos que regulan la composición de PRC1/2 en las mESCs. Además, varios informes han demostrado que, tras la diferenciación celular, ocurren ciertos cambios en la composición, aunque se sabe poco sobre la relevancia funcional de estos. En esta tesis doctoral trato de abordar estas cuestiones centrándome en dos ejemplos concretos: primero, caracterizo la red de proteínas asociadas a PRC1 tras la diferenciación de mESCs al endodermo primitivo (PrE), e intento evaluar su rol durante esta transición de identidad celular. En segundo lugar, informo del hallazgo de una nueva isoforma de splicing de Suz12, un componente central de PRC2, con implicaciones para la composición y la actividad de PRC2 en la cromatina.
Swygert, Sarah G. "The Shape of Silence: The Solution-State Conformation of Sir Heterochromatin: A Dissertation." eScholarship@UMMS, 2015. http://escholarship.umassmed.edu/gsbs_diss/790.
Full textTacheva, Silvia K. "Post-translational Modifications of Newly Synthesized Histones H3 and the Role of H3 K56 Acetylation on Chromatin Assembly in Mammalian Cells." Thesis, Boston College, 2010. http://hdl.handle.net/2345/1745.
Full textThe project I am presenting aimed to: 1. Elucidate the pattern of post- translational modification on the different variants of newly synthesized histones H3 in mammalian cells; 2. Reveal whether the acetylation of residue K56 on newly synthesized H3 histones plays a role in the incorporation of the histone into chromatin in mammalian cells; and 3. Determine whether the acetylation of residue K56 on newly synthesized H3 histones plays a role in the incorporation of the histone specifically in replicating chromatin in mammalian cells. The experiments to answer these questions were performed using HEK293 cells with inducible expression of FLAG-histones, enabling us to control the synthesis of new histones of interest and to detect and analyze their presence and relative levels in the cells. The results suggest that the acetylation of lysine 56 on histone H3 may play a positive role in the incorporation of the histone into new chromatin, and lack of acetylation may be reducing the efficiency of incorporation compared to acetylated histones
Thesis (MS) — Boston College, 2010
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Biology
Harding, Katherine. "Silencing Proteins Sir3 and Sir4 have Distinct Roles in the Assembly of Silent Chromatin in Budding Yeast." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31578.
Full textLu, Chenning. "Cooperative Binding of Sir Proteins to Nucleosomes and Its Implications for Silent Chromatin Assembly in Saccharomyces Cerevisiae." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467201.
Full textMedical Sciences
Levenstein, Mark E. "Development and characterization of a highly defined, fully recombinant in vitro chromatin assembly system with Drosophila factors /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3045785.
Full textManning, Benjamin J. "ATP-Dependent Heterochromatin Remodeling: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/795.
Full textManning, Benjamin J. "ATP-Dependent Heterochromatin Remodeling: A Dissertation." eScholarship@UMMS, 2009. http://escholarship.umassmed.edu/gsbs_diss/795.
Full textGao, Min. "Structural and Dynamic Studies of Supramolecular Assemblies by Solid State NMR Spectroscopy." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385135235.
Full textYang, Xiaofang. "Functional and Structural Dissection of the SWI/SNF Chromatin Remodeling Complex: A Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/330.
Full textBryant, Victoria. "CMG Helicase Assembly and Activation: Regulation by c-Myc through Chromatin Decondensation and Novel Therapeutic Avenues for Cancer Treatment." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6191.
Full textHughes, Amanda L. "Dissecting cis and trans Determinants of Nucleosome Positioning: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/743.
Full textHughes, Amanda L. "Dissecting cis and trans Determinants of Nucleosome Positioning: A Dissertation." eScholarship@UMMS, 2011. http://escholarship.umassmed.edu/gsbs_diss/743.
Full textAlvarez-Saavedra, Matias A. "The Snf2h and Snf2l Nucleosome Remodeling Proteins Co-modulate Gene Expression and Chromatin Organization to Control Brain Development, Neural Circuitry Assembly and Cognitive Functions." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30304.
Full textMarfella, Concetta G. A. "The Role of CHD2 in Mammalian Development and Disease: a Dissertation." eScholarship@UMMS, 2007. http://escholarship.umassmed.edu/gsbs_diss/334.
Full textKolpa, Heather J. "XIST and CoT-1 Repeat RNAs are Integral Components of a Complex Nuclear Scaffold Required to Maintain SAF-A and Modify Chromosome Architecture: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/825.
Full textKolpa, Heather J. "XIST and CoT-1 Repeat RNAs are Integral Components of a Complex Nuclear Scaffold Required to Maintain SAF-A and Modify Chromosome Architecture: A Dissertation." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/825.
Full textSalma, Nunciada. "Transcriptional Regulation During Adipocyte Differentiation: A Role for SWI/SNF Chromatin Remodeling Enzymes: A Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/50.
Full textSilveira, Alexandra C. "Characterization of SUDS3 as a BRMS1 family member in breast cancer." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/silveira.pdf.
Full textLinger, Jeffrey G. "The role of histone chaperones in double-strand DNA repair and replication-independent histone exchange /." Connect to full text via ProQuest. IP filtered, 2006.
Find full textTypescript. Includes bibliographical references (leaves 153-171). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
BERTORA, STEFANIA. "ROLE OF NUCLEAR ENVELOPE PROTEIN MAN1 IN NUCLEAR ORGANISATION AND MAINTENANCE OF GENOME STABILITY." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/554706.
Full textPennini, Meghan E. "Toll-like Receptor 2-dependent Inhibition of Interferon gamma Signaling by Mycobacterium tuberculosis." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1152115234.
Full text