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Dissertations / Theses on the topic 'Chromatin Chromatin Receptors'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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1

Strömberg, Kia. "Notch signaling: from receptor cleavage to chromatin remodeling /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-540-2/.

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2

Jiang, Yan. "Chromatin Remodeling in Transgenic Mouse Brain: Implications for the Neurobiology of Depression: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/423.

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Histone lysine methylation is an important epigenetic mark for regulation of gene expression and chromatin organization. Setdb1 (Set domain, bifurcate 1), one of the histone lysine methyltransferases, specifically methylates histone H3 at lysine 9 (H3K9) and participates in transcriptional repression and heterochromatin formation. The major task of my thesis work was to investigate the epigenetic roles of Setdb1 in regulating brain functions. I started my thesis work by examining Setdb1 expression pattern during mouse brain development. The most robust signal of Setdb1 was detected in the feta
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3

Bharadwaj, Rahul. "Regulation of Higher Order Chromatin at GRIN2B and GAD1 Genetic Loci in Human and Mouse Brain: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/651.

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Little is known about higher order chromatin structures in the human brain and their function in transcription regulation. We employed chromosome conformation capture (3C) to analyze chromatin architecture within 700 Kb surrounding the transcription start site (TSS) of the NMDA receptor and schizophrenia susceptibility gene, GRIN2B, in human and mouse cerebral cortex. Remarkably, both species showed a higher interaction between the TSS and an intronic sequence, enriched for (KRAB) Krueppel associated Box domain binding sites and selectively targeted by the (H3K9) histone 3 lysine 9 specific me
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4

Bharadwaj, Rahul. "Regulation of Higher Order Chromatin at GRIN2B and GAD1 Genetic Loci in Human and Mouse Brain: A Dissertation." eScholarship@UMMS, 2002. http://escholarship.umassmed.edu/gsbs_diss/651.

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Little is known about higher order chromatin structures in the human brain and their function in transcription regulation. We employed chromosome conformation capture (3C) to analyze chromatin architecture within 700 Kb surrounding the transcription start site (TSS) of the NMDA receptor and schizophrenia susceptibility gene, GRIN2B, in human and mouse cerebral cortex. Remarkably, both species showed a higher interaction between the TSS and an intronic sequence, enriched for (KRAB) Krueppel associated Box domain binding sites and selectively targeted by the (H3K9) histone 3 lysine 9 specific me
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5

Guan, Wenyue. "TET proteins, New Cofactors for Nuclear Receptors." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEN035/document.

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L'hormone thyroïdienne (T3) contrôle à la fois les processus développementaux et physiologiques. Elle agit via les récepteurs de l'hormone thyroïdienne (TR), membres de la famille des récepteurs hormonaux nucléaires. Ils agissent comme des facteurs de transcription dépendants du ligand. La méthylation de l'ADN en position 5 de la cytosine est une modification épigénétique importante qui affecte la structure de la chromatine et l'expression des gènes. Des études récentes ont établi un rôle important des protéines de la famille TET (Ten-eleven translocation) dans la régulation de la dynamique de
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6

Lunazzi, Giulia 1981. "Analysis of NFAT5 expression and activity in response to toll-like receptors." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/666120.

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Stimulation of Toll-like receptors (TLRs) in cells of the innate immune system activates the expression of a proinflammatory and antimicrobial gene program controlled by a network of transcriptional regulators. We show that NFAT5, which belongs to the Rel family of transcription factors and was previously characterized as an osmostress responsive factor, is required for the expression of a group of TLR-responsive genes in macrophages, such as Nos2, Il6 and Tnf. NFAT5 recruitment to its target genes is dependent on IKKβ activity, de novo protein synthesis and is sensitive to histone deacetylase
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7

Harish, S. "Transcriptional Regulation By Nuclear Receptor Homodimers Binding To The Direct Repeat Motif DR1 : Investigations In An in vitro Transcription System Derived From Rat Liver Nuclear Extracts." Thesis, Indian Institute of Science, 2000. http://hdl.handle.net/2005/164.

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Nuclear receptors (NRs) are important transcription factors involved in the regulation of a variety of physiological processes such as embryonic development, cell differentiation and homeostasis (for review, see Mangelsdorf et al., 1995 TenBaum and Baniahrned, 1997). In contrast to membrane bound receptors, they bind small lipophilic ligands and function in the nucleus as ligand-modulated transcription factors. The ligands for nuclear receptors include steroids (glucocorticoids, progestins, mineralocorticoids, androgens and estrogens), vitamin D3, retinoids, thyroid hormone, prostaglandins, fa
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8

Lee, Huay-Leng. "Glucocorticoid receptor mediated MMTV chromatin remodelling in vivo." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq28504.pdf.

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9

Wallberg, Annika. "Chromatin remodeling complexes involved in gene activation by the glucocorticoid receptor /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3956-X/.

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10

Carnesecchi, Julie. "Régulation réciproque et coopération transcriptionnelle du complexe ERRalpha-LSD1." Thesis, Lyon, École normale supérieure, 2014. http://www.theses.fr/2014ENSL0935.

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Les récepteurs nucléaires sont des facteurs de transcription qui exercent leur fonction via le contrôle de la transcription de leurs gènes cibles, une régulation qui est dépendante de cofacteurs associés. Les complexes transcriptionnels ainsi formés dialogueront avec l’environnement chromatinien (méthylation de l’ADN, remodelage des nucléosomes, modifications post-traductionnelles des histones) afin de promouvoir la répression ou l’activation transcriptionnelle des cibles géniques de ces récepteurs. Ce projet a identifié une interaction entre la lysine déméthylase LSD1 et le récepteur nucléair
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11

Le, billan Florian. "Identification et régulation transcriptionnelle des gènes cibles du récepteur des minéralocorticoïdes dans les cellules rénales." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS277.

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Le récepteur minéralocorticoïde (MR), activé par l’aldostérone, exerce de nombreuses fonctions pléïotropes, notamment au niveau rénal où il régule l’homéostasie hydrosodée. Des dysfonctionnements de la signalisation minéralocorticoïde sont impliqués dans des pathologies majeures chez l’Homme. Dans ce travail, nous avons identifié par ChIP sequencing le premier cistrome du MR dans une lignée cellulaire rénale humaine. La caractérisation des cibles génomiques a permis de décrire l’élément de réponse spécifique du MR, et de démontrer l’existence de deux modes d’action pour le MR : par liaison dir
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12

El-Hajj, Raed Ahmad. "Pharmacological and immunological identification of native [alpha]7 nicotinic receptors: evidence for homomeric and heteromeric [alpha]7 receptors /." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1198155366.

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13

Starick, Stephan Raphael [Verfasser]. "DNA sequence and chromatin landscape regulate genomic binding of the glucocorticoid receptor / Stephan Raphael Starick." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1070820016/34.

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14

Wiltshire, John Howard. "An in vitro and in vivo analysis of retinoid receptor-nucleosome interactions and chromatin remodelling." Thesis, University of Portsmouth, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494004.

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DNA is compacted in the nucleus of eukaryotic cells into chromatin and the fundamental subunit is the nucleosome that consists of an octamer of histones surrounded by 1.67 superhelical turns of 146-147 bp DNA. Nucleosomes will therefore invariably affect the regulation of gene expression by restricting the access of regulatory proteins to DNA. The retinoid receptors are class II nuclear receptors that form heterodimers and bind to retinoic acid response elements (RAREs), found in the promoters of retinoid responsive genes.
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15

Zaurín, Quer Roser. "Sequence-Dependent nucleosome positioning and chromatin remolleing of hormone-responsive genes." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7207.

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Evidències recents han remarcat la importància del paper de l'estructura de la cromatina i el posicionament de nucleosomes en processos cel·lulars bàsics com és la regulació de la transcripció gènica. L'avenç de noves tecnologies en el camp ha permès l'estudi detallat de la disposició de nucleosomes en genomes sencers. Hi ha hagut també molts intents per definir les característiques de la seqüència de l'ADN que podrien arribar a guiar el posicionament dels nucleosomes; sent el conjunt d'aquestes característiques l'anomenat "codi nucleosòmic". En la present tesis doctoral, s'aporten evidències
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16

Degner, Stephanie C. "Regulation of Cyclooxygenase-2 by Environmental and Dietary Factors." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/195632.

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Each year over 260,000 new cases of breast cancer will be diagnosed in the U.S. and approximately 40,000 women will die of metastatic breast cancer. The etiology of breast cancer is poorly understood and only 5 -10% of cases can be attributed to genetic factors. This suggests that the development of breast cancer may involve environmental factors including diet, lifestyle, and exposure to chemicals. Several lines of experimental and epidemiological evidence have highlighted COX-2 as a potential target for breast cancer prevention. The central hypothesis of this proposal is that activation o
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17

Wenger, Bryan W. "Expression of multiple populations of nicotinic acetylcholine receptors in bovine adrenal chromaffin cells." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1070496780.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xii, 120 p.; also includes graphics. Includes bibliographical references (p. 110-120).
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18

Geertsen, Susanne. "The regulation of nicotinic alpha-bungarotoxin receptors in adrenal chromaffin cells." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39391.

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The present studies investigate the molecular mechanisms involved in the nicotinic antagonist-induced up-regulation of $ alpha$-bungarotoxin ($ alpha$-BGT) binding sites in bovine adrenal chromaffin cells in culture. To assess the possibility that cellular depolarization and/or the activation of protein kinase C might be involved in the nicotinic antagonist-induced up-regulation, experiments were carried out in which nicotinic antagonists, K$ sp+$ and/or phorbol esters were added to the cells in various combinations. These latter two treatments resulted in increases in the number of toxin bind
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19

Subtil, Rodriguez Alicia. "Regulation of the 11beta-hydroxysteroid dehydrogenase type 2 promoter by steroid hormones in breast cancer cells. Convergence of progesterone receptor binding to DNA and JAK/START pathway activation." Doctoral thesis, Universitat Pompeu Fabra, 2007. http://hdl.handle.net/10803/7180.

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El gen humano 11&#61538;-HSD2 es un modelo para investigar la contribución de los efectos de los receptores de esteroides en células de cáncer de mama. El análisis del promotor mostró que la región distal está implicada en la mayor parte de la activación dependiente de hormona. En respuesta a hormona, STAT5A se recluta a la región distal y PR a las regiones distal y proximal del promotor. El reclutamiento de PR se debe a dos mecanismos diferentes, la unión directa de PR a la región proximal, y la implicación vía JAK/STAT en el reclutamiento a la región distal. La inducción del gen 11&#61538;-H
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20

Wenger, Bryan William. "Expression of multiple populations of nicotinic acetylcholine receptors in bovine adrenal chromaffin cells." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1070496780.

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21

Ovesen, Jerald Lee. "Aryl Hydrocarbon Receptor Ligands of Widely Different Toxic Equivalency Factors Induce Similar Histone Marks in Target Gene Chromatin." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1291408173.

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22

Wagatsuma, Keisuke. "STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus". 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/204582.

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23

Sankeralli, Marcel John. "A quantitative analysis of normal post-receptoral chromatic mechanisms and its applications to visual dysfunction." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=26416.

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Measurements of acquired colour deficits can aid in the detection of certain visual ailments (King-Smith (1991)). Such ailments cause selective deficits among the different neural colour and luminance coding mechanisms at the post-receptoral level. These mechanisms consist of varying combinations of inputs from the three cone types (L, M, S) responsible for phototransduction in the human visual system. An efficient colour test can measure the sensitivities of these mechanisms independently. In order to achieve this, precise estimates of the cone inputs (or cone weightings) to these mechanisms
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24

Kosilo, M. "The contribution of the luminance and opponent chromatic post-receptoral mechanisms to visual working memory." Thesis, City, University of London, 2017. http://openaccess.city.ac.uk/19357/.

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Visual Working Memory (visual WM) is an ability to encode and temporarily maintain visual information. There is some evidence that early perceptual processes make an important contribution to successful WM performance. However, perceptual contributions to WM are not yet fully understood. In vision, signals originating from three classes of photoreceptors in the retina (L, M and S-cones) are combined into three distinct mechanisms, which form the fundamentals of visual perception. These mechanisms are the two opponent chromatic mechanisms (L – M and S – (L + M)) and an achromatic, luminance mec
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25

Al-Rasheed, Nouf. "Receptor-mediated catecholamine release from chromaffin cells : the role of protein kinase C." Thesis, University of Leicester, 2006. http://hdl.handle.net/2381/29950.

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This study reveals that bovine chromaffin cells express PKC-alpha, -beta, -epsilon and -iota and that they were differentially activated by nicotine receptors and a range of Gaq/11-coupled GPCRs. Thus, nicotinic receptor stimulation recruited PKC-alpha, -beta and -epsilon from the cytoplasm to the plasma membrane, indicative of activation. In contrast, activation of Gaq/11-coupled receptors with histamine activated all the expressed PKC isoforms and angiotensin II only activated PKC-alpha and -epsilon.;Inhibition of PKC using general or isoform-selective inhibitors potentiated catecholamine re
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26

Pennini, Meghan E. "Toll-like Receptor 2-dependent Inhibition of Interferon gamma Signaling by Mycobacterium tuberculosis." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1152115234.

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27

Dammer, Eric B. "Chromatin, SF-1, and CtBP structural and post-translational modifications induced by ACTH/cAMP accelerate CYP17 transcription rate." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26595.

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Thesis (Ph.D)--Biology, Georgia Institute of Technology, 2009.<br>Committee Chair: Marion B. Sewer; Committee Member: Alfred H. Merrill, Jr.; Committee Member: Donald F. Doyle; Committee Member: Dr. Edward T. Morgan; Committee Member: Kirill S. Lobachev. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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28

Hamed, Munerah. "Characterization of the Epigenetic Signature Underlying Early Myogenic Differentiation." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39559.

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Although skeletal myogenesis is largely controlled by myogenic regulatory factors, epigenetic modifications have recently emerged as an essential regulatory mechanism of gene expression. Molecular regulation of stem cell differentiation is exerted through both genetic and epigenetic factors over distal enhancer regions. Understanding the mechanistic action of active or poised enhancers is therefore, imperative for the control of stem cell differentiation. Based on the genome-wide co-occurrence of different epigenetic marks in proliferating myoblasts, we have generated a chromatin state model t
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29

Lopez, Isabel. "Effects of antimitotic agents on cultured adrenal chromaffin cells : implications for microtubule involvement with adrenal nicotinic receptors /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487776801318513.

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30

Font, Mateu Jofre 1977. "Dynamics of progesterone receptor interactors in breast cancer cells upon hormone exposure." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/511363.

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El receptor de la progesterona és un regulador clau per la proliferació de les cèl·lules de càncer de mama dependents d’hormona. El mecanisme d’acció del PR ha tingut un paper important en la resolució del mecanisme molecular d’activació de la transcripció. No obstant això, no hi ha hagut un estudi a fons de les seves interaccions en resposta a hormona. En aquest treball s'han identificat per RIME (immunoprecipitació ràpida per l'espectrometria de masses de proteïnes endògenes) 315 interactors d’alta confiança del PR en cèl·lules de càncer de mama exposades a la potent agonista de la progester
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31

Telvi, Louise. "Effets des immunomodulateurs sur certaines fonctions lymphocytaires T." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37610262p.

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32

Sripathy, Smitha P. "MECHANISMS OF TRANSCRIPTIONAL REGULATION: GENE REPRESSION BY KRAB ZINC FINGER PROTEINS AND GENE INDUCTION BY ESTROGEN RECEPTOR beta." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1220648756.

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33

Monot, Clément. "La particule ribonucléoprotéique de l'élément L1 humain : spécificité de l'activité transcriptase inverse et partenaires cellulaires." Thesis, Nice, 2013. http://www.theses.fr/2013NICE4062.

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Les éléments LINE-1 (L1) sont les seuls éléments transposables autonomes et actifs, constituant 20% de notre ADN. Ils prolifèrent via un intermédiaire ARN dans un processus appelé rétrotransposition. Les L1s encodent deux protéines, ORF1p et ORF2p, qui s’associent avec l’ARN du L1 pour former une particule ribonucléoprotéique (RNP), constituant l’intermédiaire fonctionnel de la rétrotransposition. Les L1s « sautent » activement dans les cellules germinales, les cellules souches embryonnaires et dans l’embryon précoce, conduisant occasionnellement à des maladies génétiques. Ils sont également e
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34

Jackson, Adele. "Oxygen sensing, plasticity and catecholaminergic functions in cultured chromaffin cells of rat carotid body and adrenal medulla : modulation by chronic hypoxia and acetylcholine receptors /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0018/NQ30096.pdf.

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35

Gu, Hyangja. "The effects of antimitotic drugs and mAb35 on ?-tubulin mRNA, microtubules and nicotinic receptor-mediated catecholamine secretion in adrenal chromaffin cells in culture /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487759914759158.

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36

Zhang, Li. "Chromaffin cell scinderin redistribution, cortical F-actin disassembly and secretion are evoked by histamine through activation of the H(1) receptor-phophatidylinositol 4,5-bisphosphate transduction pathway." Thesis, University of Ottawa (Canada), 1995. http://hdl.handle.net/10393/9991.

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Nicotinic stimulation of chromaffin cells causes disassembly of cortical F-actin networks and redistribution of scinderin, a Ca$\sp{2+}$-dependent F-actin severing protein. These Ca$\sp{2+}$-dependent events precede exocytosis. Activation of scinderin by Ca$\sp+$ may cause severing of F-actin and disassembly of actin networks leaving cortical areas of low cytoplasmic viscosity which are the sites of exocytosis. Histamine is a known chromaffin cell secretagogue which induces Ca$\sp+$-dependent release of catecholamines. However, conflicting evidence exists as to the source of Ca$\sp{2+}$ utiliz
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37

Lefkowitz, Jason J. "Role of Internal Calcium Stores in Exocytosis and Neurotransmission: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/467.

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A central concept in the physiology of neurosecretion is that a rise in cytosolic [Ca2+] in the vicinity of plasmalemmal Ca2+ channels due to Ca2+ influx, elicits exocytosis. This dissertation examines the effect on both spontaneous and elicited exocytosis of a rise in focal cytosolic [Ca2+] in the vicinity of ryanodine receptors (RYRs) due to release from internal stores in the form of Ca2+ syntillas. Ca2+ syntillas are focal cytosolic transients mediated by RYRs, which we first found in hypothalamic magnocellular neuronal terminals. (Scintilla, Latin for spark, found in nerve terminals, norm
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38

Calvo, Vidal Verónica Alejandra. "Searching for a functional relationship between the breast cancer susceptibility gene BRCA1 and the progesterone receptor in breast cancer cells." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7239.

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Germ-line mutations in the breast cancer susceptibility gene BRCA1 strongly increase the risk of developing breast and ovarian cancer in women. Different hypothesis have been proposed to explain this tissue specificity. One of the most argued hypothesis is the one that proposes a link between BRCA1 and ovarian hormones' action. Much data have been published in the last years pointing to an important role of progesterone receptor (PR) in inducing normal mammary development and also breast cancer formation. This study aimed to search for a functional relationship between BRCA1 and PR in breast c
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39

Kodjo, Magloire K. "Contribution à l'étude du mécanisme d'action des tachykinines dans la régulation de la stéroïdogénèse surrénalienne chez les amphibiens." Rouen, 1996. http://www.theses.fr/1996ROUES048.

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La surrénale de la grenouille Rana ridibunda est richement innervée par un réseau de fibres contenant deux tachykinines, i. E. La ranakinine et la [Leu3, Ile7]neurokinine A. Ces deux tachykinines stimulent la sécrétion des corticostéroïdes in vitro. L'objectif du présent travail était de déterminer le mode d'action de la ranakinine sur la surrénale de grenouille et d'analyser les mécanismes de transduction associés à son effet corticotrope. Les observations en microscopie optique et électronique ont montré que les fibres A tachykinines sont étroitement associées aux seules cellules chromaffine
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40

Dermawan, Josephine Kam Tai. "From NF-κB to FACT: Mechanisms and Translational Applications of EGFR-mediated NF-κB Regulation". Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1436292263.

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41

Myers, Stephen Anthony. "Kallikrein Gene Regulation in Hormone-Dependent Cancer Cell Lines." Queensland University of Technology, 2003. http://eprints.qut.edu.au/15842/.

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Hormone-dependent cancers (HDCs), such as those of the prostate, ovary, breast and endometrium, share characteristics that indicate similar underlying mechanisms of carcinogenesis. Through steroid hormone signalling on "down-stream" target genes, the growth, development and progression of HDCs are regulated. One such family of target genes, highly expressed in HDCs and regulated by steroid hormones, are the tissue kallikreins (KLKs). The KLKs are a multigene family of serine proteases involved in physiological processes such as blood pressure regulation, inflammation, and tumour development an
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42

Bencheikh, Laura. "Fonctions nucléaires du récepteur de CSF-1 dans les monocytes humains." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS426/document.

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CSF-1R (colony-stimulating factor 1 receptor) est un récepteur transmembranaire à activité tyrosine kinase exprimé à la surface des monocytes, des macrophages et de leurs progéniteurs. Son ligand, CSF-1, oriente les cellules souches hématopoïétiques vers le lignage myéloïde et permet la différenciation des monocytes en macrophages. Une localisation nucléaire de CSF-1R a été décrite dans certaines lignées tumorales, dans des tumeurs mammaires primitives et dans les macrophages murins. Dans le noyau de ces cellules, CSF-1R régulerait la phosphorylation de protéines nucléaires et l'expression de
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43

Ruiz, Sandra. "The orphan nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2) regulates decidualization." Thèse, 2014. http://hdl.handle.net/1866/12396.

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La période de réceptivité endométriale chez l’humain coïncide avec la différentiation des cellules stromales de l’endomètre en cellules hautement spécifiques, les cellules déciduales, durant le processus dit de décidualisation. Or, on sait qu’une transformation anormale des cellules endométriales peut être à l’origine de pertes récurrentes de grossesses. LRH-1 est un récepteur nucléaire orphelin et un facteur de transcription régulant de nombreux évènements relatif à la reproduction et comme tout récepteur, son activation promouvoit l’activité transcriptionnelle de ses gènes cibles. Nous av
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44

Le, Billan Florian. "Identification et régulation transcriptionnelle des gènes cibles du récepteur des minéralocorticoïdes dans les cellules rénales." Thesis, 2017. http://www.theses.fr/2017SACLS277/document.

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Le récepteur minéralocorticoïde (MR), activé par l’aldostérone, exerce de nombreuses fonctions pléïotropes, notamment au niveau rénal où il régule l’homéostasie hydrosodée. Des dysfonctionnements de la signalisation minéralocorticoïde sont impliqués dans des pathologies majeures chez l’Homme. Dans ce travail, nous avons identifié par ChIP sequencing le premier cistrome du MR dans une lignée cellulaire rénale humaine. La caractérisation des cibles génomiques a permis de décrire l’élément de réponse spécifique du MR, et de démontrer l’existence de deux modes d’action pour le MR : par liaison dir
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POSPĚCH, Alexandr. "Attempts on chromatin immunoprecipitation with \kur{C. elegans} nuclear receptor NHR-25." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-80493.

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The aim of the work presented in this thesis was to establish chromatin immunoprecipitation method in our laboratory as a tool to study target genes of the nuclear receptor NHR-25 in C. elegans. Once the method is established, it will be also useful for studies of other DNA binding proteins. ChIP was performed in transiently transfected cells HEK293 and analyzed using PCR and qPCR. Although ChIP is typically used to find authentic target genes in the cell or in organisms, testing protein-DNA interactions by ChIP in transient transfection system (by transfecting both the expression vector of th
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"Gene-specific control of inflammation by toll-like-receptor induced chromatin modifications." YALE UNIVERSITY, 2008. http://pqdtopen.proquest.com/#viewpdf?dispub=3317263.

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Lyons, MR, and AE West. "Mechanisms of specificity in neuronal activity-regulated gene transcription." Thesis, 2011. http://hdl.handle.net/10161/5425.

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The brain is a highly adaptable organ that is capable of converting sensory information into changes in neuronal function. This plasticity allows behavior to be accommodated to the environment, providing an important evolutionary advantage. Neurons convert environmental stimuli into long-lasting changes in their physiology in part through the synaptic activity-regulated transcription of new gene products. Since the neurotransmitter-dependent regulation of Fos transcription was first discovered nearly 25 years ago, a wealth of studies have enriched our understanding of the molecular pathways th
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Tewari, Alok. "Integrated Chromatin Analyses Offer Insights Into Trans-factor Function In Cancer Cell Lines." Diss., 2012. http://hdl.handle.net/10161/5789.

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<p>Understanding the mechanisms whereby the sequence of the human genome is interpreted into diverse cellular phenotypes is a critical endeavor in modern biology. A major determinant of cellular phenotype is the spatial and temporal pattern gene expression, which is regulated in part by epigenomic properties such as histone post-translational modifications, DNA methylation, chromatin accessibility and the 3-dimensional architecture of the genome within the nucleus. These properties regulate the dynamic assembly of transcription factors and their co-regulatory proteins upon chromatin. To pro
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Sui, An Li, and 隋安莉. "Studies of muscarinic receptors in bovine adrenal medullary chromaffin cells." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/86870500390551864612.

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Hilmi, Khalid. "Mécanismes d'action des antioestrogènes totaux." Thèse, 2012. http://hdl.handle.net/1866/9718.

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Le cancer du sein est le cancer qui a la plus forte fréquence au Canada. En 2012, on estime que 23 200 nouveaux cas de cancer du sein seront diagnostiqués. Deux tiers des tumeurs mammaires expriment ou surexpriment le récepteur des oestrogènes α (ERα). De même, les oestrogènes sont importants pour la croissance de ces tumeurs. La présence des récepteurs hormonaux est un critère qui détermine le choix de la thérapie; à cet égard, le ciblage des récepteurs des oestrogènes par les antioestrogènes a pour but d’inactiver ces récepteurs et diminuer leur contribution à la croissance tumorale. Les an
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