Relevant bibliographies by topics / Chromatographie sfc

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Chromatographie sfc'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Chromatographie sfc"

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Patilaya, Popi, Dadang Irfan Husori, and Henny Sri Wahyuni. "Aktivitas Antelmintik Subfraksi dariFraksi Etanol Daun Pugun Tanoh [Picria fel-teraae (Lour.)]." Talenta Conference Series: Tropical Medicine (TM) 1, no. 3 (2018): 111–13. http://dx.doi.org/10.32734/tm.v1i3.272.

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Pugun tanoh [Picria fel-terrae (Lour.)] merupakan salah satu tumbuhan obat Indonesia yang memiliki potensi sebagai antelmintik. Ekstrak etanol daun pugun tanoh dan fraksi-fraksinya mampu membunuh cacing parasit Ascaris lumbricoides dan Ascaridia gali. Pengujian terhadap aktivitas antelmintik subfraksi dari ekstrak etanol tersebut perlu dilakukan sebagai upaya untuk memperoleh senyawa bioaktifnya. Penelitian ini bertujuan untuk mengetahui aktivitas antelmintik subfraksi dari fraksi etanol daun pugun tanoh. Penelitian dilakukan dengan memfraksinasi 20g fraksi etanol daun pugun tanoh secara kroma
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Patilaya, Popi, Dadang Irfan Husori, and Linda Marhama Daulay. "ANTHELMINTIC ACTIVITY OF SUB-FRACTIONS FROM THE N-HEXANE FRACTION OF PICRIA FEL-TERRAE LEAVES ON PHERETIMA POSTHUMA." Asian Journal of Pharmaceutical and Clinical Research 11, no. 13 (2018): 59. http://dx.doi.org/10.22159/ajpcr.2018.v11s1.26568.

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Objective: This study was to evaluate the anthelmintic activity of the subfractions (SF) from n-hexane fraction of Picria fel-terrae leaves on Pheretima posthuma.Methods: The leaves ethanolic extract of P. fel-terrae solution was mixed with water in ratio of 7:3. The mixture was fractionated with n-hexane by liquid–liquid extraction. The n-hexane fraction was then separated on silica gel by vacuum liquid chromatography with n-hexane-ethyl acetate and methanol as mobile phases. The filtrates with same chromatogram pattern were combined to produce SF of the plant leaves. The SF at the concentrat
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Knowles, David E., Bruce E. Richter, Michele B. Wygant, Lori Nixon, and Marion R. Andersen. "Supercritical Fluid Chromatography: A New Technique for AOAC." Journal of AOAC INTERNATIONAL 71, no. 3 (1988): 451–57. http://dx.doi.org/10.1093/jaoac/71.3.451.

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Abstract Supercritical fluid chromatography (SFC) is a chromatographic technique that, in many ways, is a hybrid of gas chromatography and liquid chromatography and offers many advantages over both. As this technique continues to grow in use, SFC will become very advantageous to the AOAC analyst.
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Cutillas, Víctor, Carmen Ferrer, and Amadeo R. Fernández-Alba. "Liquid chromatography versus supercritical fluid chromatography coupled to mass spectrometry: a comparative study of performance for multiresidue analysis of pesticides." Analytical and Bioanalytical Chemistry 413, no. 23 (2021): 5849–57. http://dx.doi.org/10.1007/s00216-021-03565-4.

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AbstractAbundant studies have been published evaluating different parameters of reverse-phase liquid chromatography (LC) and supercritical fluid chromatography (SFC), both coupled to electrospray (ESI)/mass spectrometry (MS) for pesticide residue analysis. However, there is a lack of a comprehensive comparative study that facilitates deep knowledge about the benefits of using each technique. In the present study, the same mass spectrometer was used coupled to both liquid and supercritical fluid chromatographies with a multiresidue method of 215 compounds, for the analysis of pesticide residues
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Pinkston, J. David. "Advantages and Drawbacks of Popular Supercritical Fluid Chromatography / Mass Spectrometry Interfacing Approaches—A User's Perspective." European Journal of Mass Spectrometry 11, no. 2 (2005): 189–97. http://dx.doi.org/10.1255/ejms.731.

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Mobile phases in supercritical fluid chromatography (SFC) have low viscosities and high diffusion coefficients with respect to those of traditional high-performance liquid chromatography (HPLC). These properties allow higher mobile phase flow rates and/or longer columns in SFC, resulting in rapid analyses and high efficiency separations. In addition, chiral SFC is becoming especially popular. Mass spectrometry (MS) is arguably the most popular “informative” detector for chromatographic separations. Most SFC/MS is performed with atmospheric pressure ionization (API) sources. Unlike LC/MS, the i
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Richter, B. E., D. J. Bornhop, J. T. Swanson, J. G. Wangsgaard, and M. R. Andersen. "Gas Chromatographic Detectors in SFC." Journal of Chromatographic Science 27, no. 6 (1989): 303–8. http://dx.doi.org/10.1093/chromsci/27.6.303.

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Yang, Yiwen, Yehui Wang, Zongbi Bao, Qiwei Yang, Zhiguo Zhang та Qilong Ren. "Progress in the Enantioseparation of β-Blockers by Chromatographic Methods". Molecules 26, № 2 (2021): 468. http://dx.doi.org/10.3390/molecules26020468.

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β-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g., timolol, are clinically marketed as an optically pure enantiomer. Therefore, the separation of racemates of β-blockers is essential both in the laboratory and industry. Many approaches have been explored to obtain the single enantiomeric β-blocker, including high performance liquid chromatography, supercritical fluid chromatography and simula
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Al Bakain, Ramia Z., Yahya Al-Degs, Bertyl Andri, Didier Thiébaut, Jérôme Vial, and Isabelle Rivals. "Supercritical Fluid Chromatography of Drugs: Parallel Factor Analysis for Column Testing in a Wide Range of Operational Conditions." Journal of Analytical Methods in Chemistry 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/5340601.

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Retention mechanisms involved in supercritical fluid chromatography (SFC) are influenced by interdependent parameters (temperature, pressure, chemistry of the mobile phase, and nature of the stationary phase), a complexity which makes the selection of a proper stationary phase for a given separation a challenging step. For the first time in SFC studies, Parallel Factor Analysis (PARAFAC) was employed to evaluate the chromatographic behavior of eight different stationary phases in a wide range of chromatographic conditions (temperature, pressure, and gradient elution composition). Design of Exp
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Li, Jian Jun, and Kevin B. Thurbide. "Novel pressure control in supercritical fluid chromatography using a resistively heated restrictor." Canadian Journal of Chemistry 87, no. 3 (2009): 490–95. http://dx.doi.org/10.1139/v09-005.

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An alternative means of independently controlling column pressure in supercritical fluid chromatography (SFC) by resistively heating the post-column restrictor is demonstrated. Compared to conventional block heating methods, resistive restrictor heating provides at least four times greater pressure programming rates and allows for much faster cooling times in between runs, thereby increasing sample throughput. When applying resistive restrictor heating in proximity to a flame ionization detector, the chromatographic baseline noise increases substantially and obscures peaks. However, adding abo
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Bajpai, Vivek K., Rajib Majumder, and Jae Gyu Park. "Isolation and purification of plant secondary metabolites using column-chromatographic technique." Bangladesh Journal of Pharmacology 11, no. 4 (2016): 844. http://dx.doi.org/10.3329/bjp.v11i4.28185.

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<p>Chromatographic techniques have significant role in natural products chemistry as well as contribute dramatically in the discovery of novel and innovative compounds of pharmaceutical and biomedical importance. This study focused on step-by-step visual demonstration of fractionation and isolation of biologically active plant secondary metabolites using column-chromatographic techniques. Isolation of bioactive compounds using column-chromatographic involves: a) Preparation of sample; b) Packing of column; c) Pouring of sample into the column; d) Elution of fractions; and e) Analysis of
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Dissertations / Theses on the topic "Chromatographie sfc"

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Martial, Frédérique. "Détection et évolution des additifs du polypropylène à l'aide de la SFC et du couplage SFE/SFC : influence sur les propriétés physiques du polypropylène." Rouen, 1995. http://www.theses.fr/1995ROUES050.

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Le polypropylène (PP) est un matériau polyvalent de plus en plus utilisé. Pour éviter qu'il se dégrade rapidement, on lui ajoute des additifs de stabilisation. Au cours du temps, ils sont consommés et on observe parallèlement le vieillissement du PP qui se caractérise par une évolution de ses propriétés. L'objectif de nos travaux était de relier la disparition des additifs avec l'évolution des propriétés mécaniques du PP vieilli, dans le but de prévoir son temps de vie en fonction de sa stabilisation et d'appliquer ces résultats au problème du recyclage. Nous avons dans un premier temps optimi
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Raimbault, Adrien. "Analyse de molécules d'intérêt biologique en chromatographie supercritique et chromatographie unifiée - Etudes fondamentales et applications." Thesis, Orléans, 2019. http://www.theses.fr/2019ORLE3021.

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La SFC est une technique analytique ancienne qui a mis du temps à s’implanter dans les mœurs des chromatographistes, restant de longues années dans l’ombre de l’HPLC et la GC. Les petites molécules peu polaires s’analysent facilement grâce à cette technique du fait de la faible polarité du dioxyde de carbone. Qu’en est-il des composés polaires ? Plusieurs méthodes ont été mises en place afin de les analyser. Une technique intermédiaire entre la SFC et l’HPLC a été utilisée, la chromatographie unifiée.Ce travail de recherche traite de méthodes pour analyser des molécules de polarité plus élevée
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West, Caroline. "Caractérisation et utilisation du carbone graphite poreux et autres phases aromatiques en chromatographie subcritique." Paris 11, 2005. http://www.theses.fr/2005PA112377.

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Iguiniz, Marion. "Développement de méthodes bidimensionnelles en ligne LCxLC-UV/MS et LCxSFC-UV pour l’analyse de composés pharmaceutiques." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1200/document.

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La chromatographie en phase liquide bidimensionnelle est une technique à fort potentiel, offrant un grand pouvoir de séparation. Après avoir démontré son intérêt dans l’industrie pharmaceutique et présenté les enjeux liés à l’analyse quantitative, une attention particulière est portée sur le développement de méthodes. Dans l’idée de développer une stratégie d’analyse générique, la première étape est de sélectionner un set de trois systèmes 2D par le biais d’une approche développée au laboratoire. La deuxième étape est d’évaluer le potentiel de ces systèmes pour l’analyse quantitative. Ces deux
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Mourier, Pierre. "La Chromatographie en phase supercritique avec le dioxyde de carbone." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37599852p.

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Adam, Frédérick Marie. "Recherche de sélectivité pour l'analyse moléculaire des distillats moyens par chromatographie multidimensionnelle." Paris 6, 2008. http://www.theses.fr/2008PA066266.

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Dans le cadre de l’amélioration de l’outil de raffinage, l’analyse moléculaire est essentielle pour la conception de modèles cinétiques utilisés pour l’optimisation des unités de production. Les techniques conventionnelles d’analyse ne permettant pas de répondre à ce challenge, la chromatographie en phase gazeuse bidimensionnelle (GC-2D) a été mise en œuvre. Le premier volet de l'étude concerne la spéciation de composés oxygénés dans les coupes gazoles. Le pouvoir résolutif de la GC-2D a été utilisé pour séparer les esters d’huiles végétales des hydrocarbures auxquels ils sont mélangés. Le dév
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Delbeke, Valérie. "Chromatographie en phase supercritique (CPS) et détection d'émission atomique (AED) appliquées à l'analyse de produits pétroliers : perspectives du couplage CPS-AED." Rouen, 1995. http://www.theses.fr/1995ROUE5022.

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La première partie de ce travail concerne l'application de la chromatographie en phase supercritique à l'analyse de produits pétroliers, notamment pour réaliser une méthode de distillation simulée. Des solutions aux difficultés rencontrées sont proposées. Dans la seconde partie, on réalise l'étude et la mise au point de la détection d'émission atomique couplée à la chromatographie en phase gazeuse. Cette technique est appliquée à l'analyse qualitative de nombreux produits pétroliers. L'analyse quantitative révèle quant à elle la nécessité d'améliorer le contrôle des différents débits des gaz u
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Lemasson, Elise. "Stratégies chromatographiques en phase liquide et supercritique pour l'analyse de candidats médicaments." Thesis, Orléans, 2018. http://www.theses.fr/2018ORLE2005/document.

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Le profilage d’impuretés de candidats médicaments est une préoccupation majeure des industries pharmaceutiques. L’identification et la quantification des impuretés doivent être strictement contrôlées pour assurer l’efficacité et la toxicité limitée du principe actif. Il est donc nécessaire de disposer de méthodes analytiques performantes afin de s’assurer que l’ensemble des impuretés est identifié. L’HPLC phase inverse sur phase C18 reste aujourd’hui la méthode de choix pour cette tâche. Cependant, il arrive que cette méthode échoue, notamment lorsque le principe actif n’est pas suffisamment r
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COUSIN, JACKY. "Couplage entre la chromatographie en phase supercritique et la spectrometrie de masse." Paris 6, 1987. http://www.theses.fr/1987PA066776.

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Conception et realisation d'un couplage entre un chromatographe en phase supercritique avec des colonnes capillaires et un spectrometre de masse, en mode d'ionisation chimique. L'appareil cps-sm a ete monte et a ete ensuite applique a l'analyse de substances peu volatiles ou thermosensibles, telles que des hydrocarbures polyaromatiques, des esters d'acides gras, des triglycerides et des peg. Comparaison avec le couplage chromatographie en phase liquide spectrometrie de masse
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Chouchi, Dalida. "Extrographie : couplage in situ entre extraction et chromatographie supercritique, application à la déterpénation et à la détoxification des huiles essentielles d'agrumes." Vandoeuvre-les-Nancy, INPL, 1995. http://www.theses.fr/1995INPL022N.

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L’utilisation du dioxyde de carbone supercritique comme éluant d'extraction pour les produits naturels a fait ses preuves depuis quelques années, toutefois, il reste peu sélectif pour le fractionnement de produits de structure chimique proche. Pour la séparation de ce type de composés, les procédés chromatographiques supercritiques, au contraire, donnent de bons résultats, cependant ceux-ci sont peu productifs par rapport à l'extraction supercritique. Dans ce travail, nous présentons les recherches sur le développement d'un nouveau procédé de fractionnement baptisé extrographie qui est le coup
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Books on the topic "Chromatographie sfc"

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Berger, T. A. Packed column SFC. The Royal Society of Chemistry, 1995.

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Workshop, on Supercritical Fluid Chromatography (1988 Park City Utah). SFC applications: The 1988 Workshop on Supercritical Fluid Chromatography, held in Park City, Utah, on January 12-14, 1988. Brigham Young University Press, 1988.

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Symposium/workshop on Supercritical Fluid Chromatography (1989 Snow Bird, Utah). SFC applications: The 1989 Symposium/workshop on Supercritical Fluid Chromatography held at Snow Bird, Utah, on June 13-15, 1989. Brigham Young University Press, 1989.

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Lubcke, K. Supercritical-fluid chromatography: Commissioning and evaluation of a Gilson SF3 for the fractioncollection of lubricant additives. University of Wolverhampton, 1993.

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Muneo, Saito, Yamauchi Yoshio, and Okuyama Tsuneo, eds. Fractionation by packed-column SFC and SFE: Principles and applications. VCH, 1994.

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BERGER, T. PACKED COLUMN SFC (Chromatography Monographs). Royal Society of Chemistry, 1995.

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Associates, White, ed. SFaCts: A comprehensive bibliography of SFC and related articles. The Associates, 1987.

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Chromatography of polymers: Characterization by SEC and FFF. American Chemical Society, 1993.

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Provder, Theodore. Chromatography of Polymers: Characterization by SEC and FFF (Acs Symposium Series). An American Chemical Society Publication, 1998.

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1939-, Provder Theodore, and American Chemical Society Meeting, eds. Chromatography of polymers: Hyphenated and multidimensional techniques. American Chemical Society, 1999.

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Book chapters on the topic "Chromatographie sfc"

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Klesper, E., and S. Küppers. "Chromatographie mit überkritischen dichten mobilen Phasen (SFC)." In Analytiker-Taschenbuch. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77526-0_2.

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Gey, Manfred H. "Chromatographie-3: LC/HPTLC & GC – SFC." In Instrumentelle Analytik und Bioanalytik. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-63952-8_6.

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Wenclawiak, Bernd. "SFC and SFE: An Introduction for Novices." In Analysis with Supercritical Fluids: Extraction and Chromatography. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-77474-4_1.

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Klesper, Ernst, and Franz P. Schmitz. "Gradients in SFC." In Analysis with Supercritical Fluids: Extraction and Chromatography. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-77474-4_5.

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Greibrokk, Tyge. "Injection Techniques in SFC." In Analysis with Supercritical Fluids: Extraction and Chromatography. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-77474-4_6.

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Brunner, Gerd. "Chromatography with Supercritical Fluids (Supercritical Fluid Chromatography, SFC)." In Topics in Physical Chemistry. Steinkopff, 1994. http://dx.doi.org/10.1007/978-3-662-07380-3_9.

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McElroy, Con R., and Thomas M. Attard. "CHAPTER 5. Supercritical Fluid Chromatography (SFC)." In Green Chemistry Series. Royal Society of Chemistry, 2018. http://dx.doi.org/10.1039/9781788013543-00106.

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Mori, Sadao, and Howard G. Barth. "SEC Method Development." In Size Exclusion Chromatography. Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-662-03910-6_5.

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Brunner, Gerd H., and Dirk Upnmoor. "Scale up of Supercritical Fluid Chromatography (SFC)." In Supercritical Fluids. Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-015-8295-7_28.

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Arpino, P. J. "Combined Supercritical Fluid Chromatography/Mass Spectrometry (SFC/MS)." In Mass Spectrometry in the Biological Sciences: A Tutorial. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2618-2_15.

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Conference papers on the topic "Chromatographie sfc"

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Bonanno, Anthony S., Kelly L. Norton, Jyisy Yang, and Peter R. Griffiths. "On-line detection for capillary and packed-column supercritical fluid chromatography by direct-deposition SFC-FTIR." In Luebeck - DL tentative, edited by Herbert M. Heise, Ernst H. Korte, and Heinz W. Siesler. SPIE, 1992. http://dx.doi.org/10.1117/12.56410.

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Strachan, S., E. Kontopoulou, D. Reinhardt, B. Giebel, and B. Thakur. "Comparison of differential ultracentrifugation (DC) and size exclusion chromatography (SEC) based exosome isolation methods." In 31. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch onkologische Forschung. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1645025.

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Ramesh, Chetan, Abhinav Bhushan, Edward Overton, and Michael C. Murphy. "Design and Fabrication of Fast Micro Heaters for Temperature Programming Micro Gas Chromatographs." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-43112.

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Prototype, low power, high rate resistance heaters for temperature programming metal micro gas chromatograph (GC) separation column chips were fabricated using UV lithography. Spin coated polyimide was used as the electrically insulating layer between the heating coil and the GC column chip because of its excellent thermal properties — in particular the ability to match the coefficient of thermal expansion with nickel and copper, and ease of application. Low resistivity, copper and nickel, metal heating elements were electrodeposited directly on the polyimide layer spin coated on top of the ni
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Qiu, Ni, Gangwen Xie, Qiang Yao, Yulong Miao, Fuping Zeng, and Liangjun Dai. "The Detection of Hydrolyzable Fluoride in SF6 Equipment by Ion Chromatography and Application in Fault Determination." In 2019 2nd International Conference on Electrical Materials and Power Equipment (ICEMPE). IEEE, 2019. http://dx.doi.org/10.1109/icempe.2019.8727271.

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Stachowiak, Jeanne C., Erin E. Shugard, Pamela Caton, et al. "Automated Sample Preparation System for Rapid Biological Threat Detection." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-80945.

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Rapid, automated sample preparation of bacterial cells and spores is required for threat analysis by remotely deployed chemical and biological warning systems. Sandia is designing, building, and testing an automated front-end sample preparation system based on miniature and microfluidic components, with the goal of concentrating bacterial species collected from the air, harvesting and solubilizing proteins from them, and delivering them to Sandia’s MicroChemLab capillary gel electrophoresis system1,2 for analysis (Fig. 1). Miniature, motorized valves and pumps control flow between system compo
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Owen, B. A., and W. G. Owen. "ASSOCIATION OF HEPARIN AND FACTOR Xa: INFLUENCE ON THE RATE OF INHIBITION OF FACTOR Xa BY ANTITHROMBIN III-HEPARIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643837.

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Association of heparin non-covalently with bovine factor Xa was analyzed by Superose-12 gel chromatography. In 0.05 M NaCl, 0.02 M Tris, pH 7.5, DEGR-Xa (factor Xa inactivated by dans-Glu-Gly-Arg-CH2Cl) was eluted as a single, sharp peak at Ve/Vt=0-65 (elution volume/internal volume). Mixtures of heparin and DEGR-Xa were eluted as two partially resolved peaks of protein at Ve/Vt=0.59 and 0.65. The fraction of DEGFUXa in the leading peak was directly proportional to [heparin], and at 100 yM heparin the leading peak contained more than half the total protein. When 0.02 M HEPES was substituted fo
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Orthner, Carolyn L., Prabir Bhattacharya, and Dudley K. Strikland. "PURIFICATION AND CHARACTERIZATION OF A PROTEIN C ACTIVATOR FROM THE VENOM OF AGKISTRODON CONTORTRIX CONTORTRIX." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643813.

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There are two recent reports on the purification and properties of a protein C activator (PCA) from the venom of the Southern copperhead snalce. The purification of a 37,000 Mr nonenzymatic PCA (Martinoli and Stocker, Thrcmb. Res. 43, 253, 1976) as well as of a 20,000 Mr thrombin-like enzyme (Klein and Walker, Biochem. ,25, 4175, 1986) have been described. The purpose of this investigation was to purify and further characterize the PCA(s) from this vencm. A PCA has been isolated by sulphopropyl-Sephadex followed by gel filtration chromatography resulting in approximately a 100-fold purificatio
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Palareti, G., M. Maccaferri, M. Poggi, et al. "EFFECTS OF GABEXATE MESILATE (FOY), A NEW SYNTHETIC SERINE PROTEASE INHIBITOR, ON BLOOD COAGULATION IN PATIENTS WITH DIC." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644343.

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A pilot open controlled study of FOY was performed in 20 intensive care patients (pts, age 18-63) with DIC diagnosed with standard laboratory criteria (at least 3 of the following: Normotest 70%, fibrinogen 150 mg%, AT III 80%, FDP 20 ug/ml, platelets 150000). Besides the usual treatments, FOY was given to 10 pts (FOY G.) by continuous i.v. infusion (1mg/kg/h) for up to 7 days, while in 10 control pts (Hep.G.) the treatment included low dose s.c. heparin. Blood clotting tests were performed at admission to the study and daily for 7 days; we consider here results obtained at baseline and at the
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Winocour, P. P., P. D. Rand, J. D. Vickers, R. L. Kinlough-Rathbone, and J. F. Mustard. "ENHANCED THROMBIN-INDUCED AGGREGATION AND INOSITOL TRISPHOSPHATE FORMATION OF PLATELETS FROM SPONTANEOUSLY HYPERCHOLESTEROLEMIC RATS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643811.

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Platelets from rats with diet-induced hypercholesterolemia are hypersensitive to thrombin through a pathway independent of released ADP or thromboxane A2 (TXA2) formation. We examined if platelets from rats with spontaneous hypercholesterolemia (HC) are similarly hypersensitive. HC rats (plasma cholesterol: 130±4 mg/dl, n=15) were compared with their normocholesterolemic genetic controls (NC) (87±4 mg/dl, p<0.001, n=16). Total cholesterol/109 platelets was not different between the groups (HC: 0.314±0.032 μmole, n=7; NC: 0.357±0.046 ymole, n=7). Washed platelets were prelabelled with 14c-se
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