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Journal articles on the topic 'Chromone derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Talhi, Oualid, Norah Bennamane, Artur Silva, et al. "Catalyst-Free One-Pot Synthesis of Chromeno-Imidazo-Pyridinones by an Aza-Michael Addition/Rearrangement/Heterocyclization Tandem Reaction." Synlett 29, no. 11 (2018): 1437–40. http://dx.doi.org/10.1055/s-0037-1609684.

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A one-pot synthesis of a novel series of chromeno-imidazo-pyridinone derivatives from 3-[(2-hydroxyphenyl)-3-oxoprop-1-en-1-yl]chromones and ethane-1,2-diamine at room temperature under catalyst-free conditions has been successfully developed. This approach involves a tandem aza-Michael addition reaction, a chromone-to-chromanone rearrangement, and a heterocyclization sequence, leading to chromeno-imidazo-pyridinone polyheterocycles. The structure and absolute configurations of the new compounds were elucidated by a combination of 1D- and 2D-NMR analyses and single-crystal X-ray diffraction.

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2

Mrug, Galyna, and Mykhaylo Frasinyuk. "Advances in chemistry of chromone aminomethyl derivatives." French-Ukrainian Journal of Chemistry 3, no. 2 (2015): 21–39. http://dx.doi.org/10.17721/fujcv3i2p21-39.

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Chromones play an important role in the design and discovery of new pharmacologically active compounds. A large volume of reports dedicated to synthesis and study of properties of nitrogen-containing chromone derivatives show important role of chromone alkaloid-like compounds. The present review covers achievements in the field of synthesis of chromone aminomethyl derivatives as one of perspective scaffolds.

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3

Deharkar, Pravin, Shridhar Satpute, and Deepa Panhekar. "Synthetic Routes and Biological Activities of Chromone Scaffolds: An Overview." Asian Journal of Chemistry 35, no. 4 (2023): 771–93. http://dx.doi.org/10.14233/ajchem.2023.23442.

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The central backbones of natural assets and therapeutic medications are chromone and flavone. Utilizing such preferred chalcone analogs in drug research has shown a successful blueprint, yielding new hits/leads and fast optimization procedures. Chromone can create novel molecules with pharmacological promise, particularly in neurological, inflammatory, infectious diseases, cancer and diabetes. The current perspective focuses mainly on flavones and flavonoids of biological significance, such as chromon-4-one analogs, both synthetic and natural sources. Furthermore, because drug repurposing is n

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4

Gomes, Ligia R., John Nicolson Low, Fernando Cagide, Alexandra Gaspar, and Fernanda Borges. "A comparison of the structures of some 2- and 3-substituted chromone derivatives: a structural study on the importance of the secondary carboxamide backbone for the inhibitory activity of MAO-B." Acta Crystallographica Section E Crystallographic Communications 71, no. 11 (2015): 1270–77. http://dx.doi.org/10.1107/s2056989015017958.

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The crystal structures of the 3-substituted tertiary chromone carboxamide derivative, C17H13NO3,N-methyl-4-oxo-N-phenyl-4H-chromene-3-carboxamide (1), and the chromone carbonyl pyrrolidine derivatives, C14H13NO3, 3-(pyrrolidine-1-carbonyl)-4H-chromen-4-one (3) and 2-(pyrrolidine-1-carbonyl)-4H-chromen-4-one (4) have been determined. Their structural features are discussed and compared with similar compounds namely with respect to their MAO-B inhibitory activities. The chromone carboxamide presents a –synconformation with the aromatic rings twisted with respect to each other [the dihedral angle

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5

Lei, Jie, Yong Li, Liu-Jun He, et al. "Expeditious access of chromone analogues via a Michael addition-driven multicomponent reaction." Organic Chemistry Frontiers 7, no. 8 (2020): 987–92. http://dx.doi.org/10.1039/d0qo00145g.

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A Michael addition-driven four-component reaction (4-CR) with four Ugi inputs was developed and utilized for the synthesis of chromone derivatives and tetrazole substituted chromones under mild reaction conditions.

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6

Michalska, Marta, Wojciech Pajak, Justyna Kołodziejska, Andrzej Lazarenkow, and Jolanta Nawrot-Modranka. "Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin." Acta Biochimica Polonica 55, no. 3 (2008): 613–17. http://dx.doi.org/10.18388/abp.2008_3068.

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The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.

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7

K., P. Swathi*1 Mary Mathew2 Gayathri3. "In-Silico Design, Synthesis and Antiprolifertive Evaluation of Thiazolidino-Chromone Derivatives." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 249–60. https://doi.org/10.5281/zenodo.14975982.

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Chromones are a group of naturally occurring chemical compound that being existing everywhere in nature, predominantly in plants. The word chromone is derived from the Greak word Chroma,which means colour, which bringing up that most of chromone derivatives can exhibit distinctiveness, in colour.Chromones are the oxygen containing heterocyclic compounds with a benzoannelated γ-Pyrone ring (4H-Chromone-4-one,4H-benzopyran-4-one). Now a days chromone act as a valid scaffold in medicinal chemistry. Our aim was to develop novel thizolidino- chromone derivatives which inhibiting Human Topo (I

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8

Sugiyama, Takuji, Yuji Narukawa, Shunsuke Shibata, Ryo Masui, and Fumiyuki Kiuchi. "New 2-(2-Phenylethyl)chromone Derivatives and Inhibitors of Phosphodiesterase (PDE) 3A from Agarwood." Natural Product Communications 11, no. 6 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100624.

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The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6,8-dihydroxy-2-[2-(4′-methoxyphenyl)ethyl]chromone (6), and 6,7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3 A inhibitory activity with IC50 of 4.83 μM.

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9

Gomes, Ligia R., John Nicolson Low, Carlos Fernandes, Alexandra Gaspar, and Fernanda Borges. "Crystal structures of ethyl 6-(4-methylphenyl)-4-oxo-4H-chromene-2-carboxylate and ethyl 6-(4-fluorophenyl)-4-oxo-4H-chromene-2-carboxylate." Acta Crystallographica Section E Crystallographic Communications 72, no. 1 (2016): 8–13. http://dx.doi.org/10.1107/s2056989015022781.

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The crystal structures of two chromone derivatives,viz.ethyl 6-(4-methylphenyl)-4-oxo-4H-chromene-2-carboxylate, C19H16O4, (1), and ethyl 6-(4-fluorophenyl)-4-oxo-4H-chromene-2-carboxylate C18H13FO4, (2), have been determined: (1) crystallizes with two molecules in the asymmetric unit. A comparison of the dihedral angles beween the mean planes of the central chromone core with those of the substituents, an ethyl ester moiety at the 2-position and apara-substituted phenyl ring at the 6-position shows that each molecule differs significantly from the others, even the two independent molecules (a

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10

Tarasenko, Dmytro O., Andriy Y. Chumak, Oleksii O. Kolomoitsev, Volodymyr M. Kotliar, and Alexander D. Roshal. "Synthesis of a New Series of Chromones Based on Formylthiazoles." Journal of Organic and Pharmaceutical Chemistry 21, no. 4 (2023): 3–10. http://dx.doi.org/10.24959/ophcj.23.292844.

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A preparative approach to thiazole-containing chromone derivatives has been developed by modifying the corresponding aldehydes with their further transformation into propenone derivatives, and finally introducing them into the Algar-Flynn-Oyamada reaction. Several methods for obtaining propenones have been analyzed, and the most effective and practically convenient one has been found. The thiazole-containing analogs of chromones obtained have a great potential as probes for a wide range of studies.

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11

Kowalska, Ewelina, Lesław Sieroń, and Anna Albrecht. "Enantioselective, Decarboxylative (3+2)-Cycloaddition of Azomethine Ylides and Chromone-3-Carboxylic Acids." Molecules 27, no. 20 (2022): 6809. http://dx.doi.org/10.3390/molecules27206809.

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Herein, we describe the synthesis of a variety of chiral hybrid pyrrolidine-chromanone polycyclic derivatives. A convenient (3+2)-annulation of azomethine ylides with chromone-3-carboxylic acid realized under Brønsted base catalysis produced highly functionalized products in high yields with good stereoselectivities through asymmetric, intermolecular, and decarboxylative (3+2)-cyclization.

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12

Gomes, Ligia R., John Nicolson Low, Fernando Cagide, Daniel Chavarria, and Fernanda Borges. "New insights in the discovery of novelh-MAO-B inhibitors: structural characterization of a series ofN-phenyl-4-oxo-4H-chromene-3-carboxamide derivatives." Acta Crystallographica Section E Crystallographic Communications 71, no. 5 (2015): 547–54. http://dx.doi.org/10.1107/s2056989015007859.

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SixN-substituted-phenyl 4-oxo-4H-chromene-3-carboxamides, namelyN-(2-nitrophenyl)-4-oxo-4H-chromene-3-carboxamide, C16H10N2O5(2b),N-(3-methoxyphenyl)-4-oxo-4H-chromene-3-carboxamide, C17H13NO4, (3a),N-(3-bromophenyl)-4-oxo-4H-chromene-3-carboxamide, C16H10BrNO3, (3b),N-(4-methoxyphenyl)-4-oxo-4H-chromene-3-carboxamide, C17H13NO4, (4a),N-(4-methylphenyl)-4-oxo-4H-chromene-3-carboxamide, C17H13NO3, (4d), andN-(4-hydroxyphenyl)-4-oxo-4H-chromene-3-carboxamide, C16H11NO4, (4e), have been structurally characterized. All compounds exhibit ananticonformation with respect to the C—N rotamer of the ami

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13

Shablykina, Olga, Viktoriia Moskvina, and Volodymyr Khilya. "Features of the synthesis and biological evaluation of 3-(carboxyphenyl)chromones." Ukr. Bioorg. Acta 2020, Vol. 15, N2 15, no. 2 (2020): 3–12. http://dx.doi.org/10.15407/bioorganica2020.02.00.

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Flavonoids and their derivatives have historically been a source of therapeutic agents. Every year, more and more data is published on new flavonoid compounds, both synthetic and isolated from natural sources, and their innumerable physiological and pharmacological activities. This review presents synthetic routes towards 3-(carboxyphenyl)chromones and evaluation of their biological activity as published in both journal and patent literature. We have focused specifically on the 3-(carboxyphenyl)chromones, because while methods of synthesis and biological activity of 2(3)-substituted and 2,3-di

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14

Shablykina, Olga V., Viktoriia S. Moskvina, and Volodymyr P. Khilya. "Features of the synthesis and biological evaluation of 3-(carboxyphenyl)chromones." Ukrainica Bioorganica Acta 15, no. 2 (2020): 3–12. http://dx.doi.org/10.15407/bioorganica2020.02.003.

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Flavonoids and their derivatives have historically been a source of therapeutic agents. Every year, more and more data is published on new flavonoid compounds, both synthetic and isolated from natural sources, and their innumerable physiological and pharmacological activities. This review presents synthetic routes towards 3-(carboxyphenyl)chromones and evaluation of their biological activity as published in both journal and patent literature. We have focused specifically on the 3-(carboxyphenyl)chromones, because while methods of synthesis and biological activity of 2(3)-substituted and 2,3-di

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15

Pozdnyakov, Dmitry I., Andrey V. Voronkov, Anastasiya E. Rybalko, Viktoriya M. Rukovitsyna, and Eduard T. Oganesyan. "Chromone-3-aldehyde derivatives – sirtuin 2 inhibitors for correction of muscular dysfunction." Current Issues in Pharmacy and Medical Sciences 32, no. 1 (2019): 45–50. http://dx.doi.org/10.2478/cipms-2019-0010.

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Abstract The aim of the study was to evaluate experimentally, the myoprotective effect of new chromone-3-aldehyde derivatives in conditions of muscular dysfunction and to establish a potential mechanism of myoprotective activity – the blockade of the function of sirutin 2. Materials and methods. The effect of new chromone-3-aldehyde derivatives on the development of muscular dysfunction under the conditions of an electromiostimulation test, was studied. The degree of muscle fatigue was evaluated in the «grip-strength» and through test biochemical assays (determination of the activity of lactat

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16

Maicheen, Chirattikan, Chokchaloemwat Churnthammakarn, Nichapat Pongsroypech, et al. "One-Pot Synthesis and Evaluation of Antioxidative Stress and Anticancer Properties of an Active Chromone Derivative." Molecules 28, no. 7 (2023): 3129. http://dx.doi.org/10.3390/molecules28073129.

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Chromones are the structural building blocks of several natural flavonoids. The synthesis of chromones, which contain a hydroxy group on the ring, presents some challenges. We used the one-pot method to synthesize ten chromone derivatives and two related compounds using modified Baker-Venkataraman reactions. The structures were confirmed using FT-IR, 1H NMR, 13C NMR, and HRMS. The in vitro antioxidant assay revealed that compounds 2e, 2f, 2j, and 3i had potent antioxidant activity and that all these synthesized compounds, except those containing nitro groups, were harmless to normal cells. In

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17

Kumla, Decha, José Pereira, Tida Dethoup, et al. "Chromone Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Penicillium erubescens KUFA0220 and Their Antibacterial Activity." Marine Drugs 16, no. 8 (2018): 289. http://dx.doi.org/10.3390/md16080289.

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A previously unreported chromene derivative, 1-hydroxy-12-methoxycitromycin (1c), and four previously undescribed chromone derivatives, including pyanochromone (3b), spirofuranochromone (4), 7-hydroxy-6-methoxy-4-oxo-3-[(1E)-3-oxobut-1-en-1-yl]-4H-chromene-5-carboxylic acid (5), a pyranochromone dimer (6) were isolated, together with thirteen known compounds: β-sitostenone, ergosterol 5,8-endoperoxide, citromycin (1a), 12-methoxycitromycin (1b), myxotrichin D (1d), 12-methoxycitromycetin (1e), anhydrofulvic acid (2a), myxotrichin C (2b), penialidin D (2c), penialidin F (3a), SPF-3059-30 (7), G

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18

Shokol, Tatyana, Natalia Gorbulenko, Magdalina Tsapko, and Volodymyr Khilya. "Mannich Bases of Chromones Containing a 2,3-fused Heterocyclic Ring." French-Ukrainian Journal of Chemistry 12, no. 1 (2024): 1–16. https://doi.org/10.17721/fujcv12i1p1-16.

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Aminomethylation of chromones сontaining a 2,3-fused heterocyclic ring, such as indolizine, pyrroloquinoline and pyrrolothiazole, namely 9-hydroxy-6/8-alkyl-12H-chromeno[3,2-a]indolizin-12-ones, 10-(alk)oxy-9-R-7Н-сhromeno[3',2':3,4]pyrrolo[1,2-а]quinolin-7-ones and 9-alkyl-8-hydroxy-3-methyl-5-R-11H-chromeno[3’,2’:3,4]pyrrolo[2,1-b][1,3]thiazol-11-ones with bisdialkylaminomethanes was studied. The α-position of the pyrrole ring and the ortho-positions to the hydroxyl group in the benzene ring in the above mentioned systems are active sites and the Mannich reaction can occur at these three pos

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19

Chua, Lee Suan, Abirame Segaran, and Hoi Jin Wong. "LC-PDA-MS/MS-Based Characterization of Key Phytochemicals in Eurycoma Longifolia Roots." Journal of Chromatographic Science 59, no. 7 (2021): 659–69. http://dx.doi.org/10.1093/chromsci/bmab041.

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Abstract The objective of the study was to fractionate the crude extract of Eurycoma longifolia (E. longifolia) roots and identify the intense peaks using HPLC-PDA-MS/MS, UPLC–MS/MS and H-NMR. Column chromatography was used to fractionate the crude extract into individual fractions using six solvent systems ranged from ethyl acetate, methanol and water in increasing polarity. Two fractions with nearly pure and intense peaks were selected for compound identification. Chromenone (coumarin) and chromone derivatives were putatively identified, besides several previously reported quassinoid glycosi

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20

Benny, Anjitha Theres, Sonia D. Arikkatt, Cijo George Vazhappilly, et al. "Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity." Mini-Reviews in Medicinal Chemistry 22, no. 7 (2022): 1030–63. http://dx.doi.org/10.2174/1389557521666211124141859.

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: Chromones are the class of secondary metabolites that broadly occur in the plant kingdom in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged scaffolds in compounds” in medicinal chemistry. Their wide biological responses have made them an important moiety in a drug discovery program. This review provides updates on the various methods of synthesis of chromones and biological applications in medicinal chemistry. Various synthetic strategies for the construction of chromones include readily available phenols, salicylic acid and its derivatives, ynones, chal

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21

Machado, N. F. L., and M. P. M. Marques. "Bioactive Chromone Derivatives – Structural Diversity." Current Bioactive Compounds 6, no. 2 (2010): 76–89. http://dx.doi.org/10.2174/157340710791184859.

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22

Ibrahim, Sabrin R. M. "New 2-(2-Phenylethyl)chromone Derivatives from the Seeds of Cucumis melo L var. reticulatus." Natural Product Communications 5, no. 3 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500313.

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Chemical investigation of the methanolic extract of the seeds of Cucumis melo L. var. reticulatus (Cucurbitaceae) afforded three new chromone derivatives; 5,7-dihydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone 3, 5,7-dihydroxy-2-[2-(3,4-dihydroxyphenyl)ethyl]chromone 4, and 7-glucosyloxy-5-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone 6, together with three known compounds; β-amyrin 1, β-sitosterol 2, and β-sitosterol-3- O-β-glucopyranoside 5. Their structures were established by UV, IR, 1D and 2D NMR, in addition to mass spectroscopic data and comparison with literature data. The n-hexane and meth

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23

Faizal, Ahmad, Rizkita Rachmi Esyanti, Nadia Puji Utami, et al. "Elicitation of Secondary Metabolites in Aquilaria malaccensis Lam. Callus Culture by Crude Mycelial Extract of Fusarium solani and Methyl Jasmonate." Forests 14, no. 1 (2022): 48. http://dx.doi.org/10.3390/f14010048.

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Agarwood is a resinous wood of great economic value produced by trees from the Thymelaeaceae family in response to stress. The natural formation of agarwood can take decades after exposure to the stressors. Artificial agarwood induction by inoculating the stem with fungi has been successfully demonstrated, but resin accumulation occurs very slowly. Cell suspension and callus cultures may serve as an alternative solution to provide a fast-growing plant material to produce artificial agarwood in a short period. Here, we induced agarwood formation in callus cultures of Aquilaria malaccensis by ap

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24

Han, Shouye, Yu Liu, Wan Liu та ін. "Chromone Derivatives with α-Glucosidase Inhibitory Activity from the Marine Fungus Penicillium thomii Maire". Molecules 26, № 17 (2021): 5273. http://dx.doi.org/10.3390/molecules26175273.

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The fungal strain YPGA3 was isolated from the sediments of the Yap Trench and identified as Penicillium thomii. Eight new chromone derivatives, named penithochromones M−T (1–8), along with two known analogues, 9 and 10, were isolated from the strain. The structures were established by detailed analyses of the spectroscopic data. The absolute configuration of the only chiral center in compound 1 was tentatively determined by comparing the experimental and the calculated specific rotations. Compounds 7 and 8 represent the first examples of chromone derivatives featuring a 5,7-dioxygenated chromo

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25

Molefe, Duduzile M., Mlungiseleli M. Ganto, Kevin A. Lobb, and Perry T. Kaye. "Chromone Studies. Part 17. Tricyclic Scaffolds from Reactions of chromone-3-carbaldehydes and methyl vinyl ketone under Baylis–Hillman conditions." Journal of Chemical Research 2009, no. 7 (2009): 452–56. http://dx.doi.org/10.3184/030823409x465277.

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Reaction of a series of chromone-3-carbaldehydes with methyl vinyl ketone under Baylis–Hillman conditions, using 3-hydroxyquinuclidine in chloroform or DABCO in 1-methyl-2-pyrrolidinone, affords unprecedented tricylic chromone derivatives which, depending on the conditions, may be accompanied by the normal Baylis–Hillman products or their respective tricyclic dimers.

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26

Soujanya, Jilla, D. Ravisankar Reddy, and Gade Kalyani. "Synthesis, Characterization and Biological Evaluation of Novel Triazole Linked Chromone Biheterocycle Analogs." Asian Journal of Chemistry 34, no. 1 (2021): 53–59. http://dx.doi.org/10.14233/ajchem.2022.23420.

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The current work focused on the synthesis of novel chromone biheterocycle analogs followed by its characterization through physico-chemical and spectral techniques like FTIR, mass and NMR spectroscopy. The basic triazole heterocycle and its analogs have different biological properties. At the point when one biological active molecule is connected to another, the resultant shows improved potency (biheterocycles). Chromone and triazole are selected in this study to develop new efficient, simple, economically viable and biologically active synthetic compounds. All the novel derivatives of triazol

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27

Wang, Sin-Ling, Hsiang-Ruei Liao, Ming-Jen Cheng, et al. "Four New 2-(2-Phenylethyl)-4H-chromen-4-one Derivatives from the Resinous Wood of Aquilaria sinensis and Their Inhibitory Activities on Neutrophil Pro-Inflammatory Responses." Planta Medica 84, no. 18 (2018): 1340–47. http://dx.doi.org/10.1055/a-0645-1437.

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AbstractFour new 2-(2-phenylethyl)-4H-chromen-4-one derivatives, 6-hydroxy-5-methoxy-2-[2-(4′-methoxyphenyl)ethyl]chromone (1), 6,7-dimethoxy-2-[2-(2′-hydroxyphenyl)ethyl]chromone (2), 5-hydroxy-6-methoxy-2-[2-(3′-methoxyphenyl)ethyl]-chromone (3), and 7-chloro-8-hydroxy-2-[2-(4′-methoxyphenyl)ethyl]chromone (4), have been isolated from the resinous wood of Aquilaria sinensis, together with 16 known compounds (5–20). Among these, 7-methoxy-2-[2-(4′-methoxyphenyl)ethyl]chromone (5) was isolated from a natural source for the first time. The structures of the new compounds were established by spe

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28

HASHIMOTO, KEIJI, SACHIKO NAKAHARA, TAKEHISA INOUE, YOSHIO SUMIDA, MUTSUKO TAKAHASHI, and YOSHIRO MASADA. "A new chromone from agarwood and pyrolysis products of chromone derivatives." CHEMICAL & PHARMACEUTICAL BULLETIN 33, no. 11 (1985): 5088–91. http://dx.doi.org/10.1248/cpb.33.5088.

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29

Dong, Wen-Hua, Hao Wang, Feng-Juan Guo, et al. "Three New 2-(2-Phenylethyl)chromone Derivatives of Agarwood Originated from Gyrinops salicifolia." Molecules 24, no. 3 (2019): 576. http://dx.doi.org/10.3390/molecules24030576.

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Two new 2-(2-phenylethyl)chromone derivatives (1–2), comprising 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone and benzylacetone moieties, together with one new 2-(2-phenylethenyl)chromone (3) were isolated from the ethyl acetate extraction of agarwood originated from Gyrinops salicifolia Ridl. All structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. All isolated compounds were tested for acetylcholinesterase (AChE) inhibitory activity and cytotoxic activity against human myeloid leukemia cell line (K562). However, none of the compounds displ

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30

Rajadurai, S., and P. K. Das. "Reactivity and photophysical behavior of chromone triplet. A laser flash photolysis study." Canadian Journal of Chemistry 65, no. 9 (1987): 2277–85. http://dx.doi.org/10.1139/v87-379.

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The chromone triplet ([Formula: see text] in acetonitrile) is produced in quantitative yields upon 308- or 337.1-nm laser pulse excitation and is characterized by submicrosecond lifetimes in solutions at room temperature. The short-lived nature of the triplet is attributable to intrinsically fast T1 [Formula: see text] S0 intersystem crossing, nearly diffusion-limited self-quenching, and facile interactions with solvents in the form of charge and hydrogen-atom transfer. The unusually high self-quenching rate constants, (0.9–4.0) × 109 M−1 s−1, are related in a major part to the presence of the

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31

Saha, Arijit, Soumen Payra, and Subhash Banerjee. "On water synthesis of pyran–chromenes via a multicomponent reactions catalyzed by fluorescent t-ZrO2nanoparticles." RSC Advances 5, no. 123 (2015): 101664–71. http://dx.doi.org/10.1039/c5ra19290k.

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Here, we have reported multicomponent synthesis of diverse pyran fused chromenes namely 2-aminochromene, dihydropyrano[3,2-c]chromene, and chromeno[4,3-b]chromene derivatives using fluorescentt-ZrO<sub>2</sub>nanoparticles as reusable catalyst in water.

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32

Albuquerque, Hélio M. T., Clementina M. M. Santos, José A. S. Cavaleiro, and Artur M. S. Silva. "First intramolecular Diels–Alder reactions using chromone derivatives: synthesis of chromeno[3,4-b]xanthones and 2-(benzo[c]chromenyl)chromones." New Journal of Chemistry 42, no. 6 (2018): 4251–60. http://dx.doi.org/10.1039/c7nj05185a.

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33

Zhang, Xin-Wen, Yan-Song Ye, Fan Xia, Xing-Wei Yang, and Gang Xu. "Diverse Polyphenols from Hypericum faberi." Natural Products and Bioprospecting 9, no. 3 (2019): 215–21. http://dx.doi.org/10.1007/s13659-019-0206-1.

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Abstract Six new polyphenols with different isoprenylated xanthones, isoprenylated acylphloroglucinols, and chromone architectures, hyperfaberols A–F (1–6), were isolated from the whole plants of Hypericum faberi along with seven other related known compounds. In which hyperfaberols A/B (1/2) and 12–13 were isoprenylated xanthones, hyperfaberols C–E (3–5) and 8–11 were seven isoprenylated acylphloroglucinol derivatives, while 6–7 were two chromones. Their structures were elucidated by comprehensive analysis of their spectroscopic data as well as detailed comparison with the literature data. Co

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Park, Jang Hyun, Seung Uk Lee, Sang Hoon Kim, et al. "Chromone and chromanone derivatives as strand transfer inhibitors of HIV-1 integrase." Archives of Pharmacal Research 31, no. 1 (2008): 1–5. http://dx.doi.org/10.1007/s12272-008-1111-z.

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Mucha, Paulina, Pawel Hikisz, Krzysztof Gwoździński, Urszula Krajewska, Andrzej Leniart, and Elzbieta Budzisz. "Cytotoxic effect, generation of reactive oxygen/nitrogen species and electrochemical properties of Cu(ii) complexes in comparison to half-sandwich complexes of Ru(ii) with aminochromone derivatives." RSC Advances 9, no. 55 (2019): 31943–52. http://dx.doi.org/10.1039/c9ra05971g.

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Marinov, Teodor, Zlatina Kokanova-Nedialkova, and Paraskev Nedialkov. "UHPLC-HRMS-based profiling and simultaneous quantification of the hydrophilic phenolic compounds from the aerial parts of Hypericum aucheri Jaub. & Spach (Hypericaceae)." Pharmacia 71 (April 4, 2024): 1–11. http://dx.doi.org/10.3897/pharmacia.71.e122436.

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A validated UHPLC-HRMS method was developed to identify and quantify polar phenolic metabolites in the EtOH extract from H. aucheri Jaub. & Spach’s aerial parts. The external standards, chlorogenic acid, mangiferin, and hyperoside were selected in this analysis. Forty-four compounds, encompassing hydroxybenzoic and hydroxycinnamic acids derivatives, benzophenones, catechins, xanthones, flavonols, biflavones, and chromones were detected and quantified in the aerial parts of the titled plant. Pentahydroxyxanthone-C-glycoside 15, maclurin-O-(benzoyl)-hexoside 37, norathyriol-O-(benzoyl)-hexos

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Marinov, Teodor, Zlatina Kokanova-Nedialkova, and Paraskev Nedialkov. "UHPLC-HRMS-based profiling and simultaneous quantification of the hydrophilic phenolic compounds from the aerial parts of Hypericum aucheri Jaub. & Spach (Hypericaceae)." Pharmacia 71, no. () (2024): 1–11. https://doi.org/10.3897/pharmacia.71.e122436.

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A validated UHPLC-HRMS method was developed to identify and quantify polar phenolic metabolites in the EtOH extract from <i>H. aucheri</i> Jaub. & Spach's aerial parts. The external standards, chlorogenic acid, mangiferin, and hyperoside were selected in this analysis. Forty-four compounds, encompassing hydroxybenzoic and hydroxycinnamic acids derivatives, benzophenones, catechins, xanthones, flavonols, biflavones, and chromones were detected and quantified in the aerial parts of the titled plant. Pentahydroxyxanthone-C-glycoside 15, maclurin-O-(benzoyl)-hexoside 37, norathyriol-O-(benzoyl

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Boduszek, Bogdan, Marcin Lipiński та Maria W. Kowalska. "AMINOPHOSPHONIC DERIVATIVES OF CHROMONE. SYNTHESIS OF NOVEL CHROMONE-3-(α-AMINO) METHANEPHOSPHONIC ACIDS". Phosphorus, Sulfur, and Silicon and the Related Elements 143, № 1 (1998): 179–89. http://dx.doi.org/10.1080/10426509808045496.

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Nastasă, Cristina Mariana, Mihaela Duma, Adrian Pîrnău, Laurian Vlase, Brîndușa Tiperciuc, and Ovidiu Oniga. "Development of new 5-chromenyl-2,4-thiazolidinediones as antimicrobial agents." Medicine and Pharmacy Reports 89, no. 1 (2015): 122–27. http://dx.doi.org/10.15386/cjmed-509.

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Background and aims. In the context of the increasing phenomenon of microbial resistance to usual drugs, the development of new treatment strategies and new therapeutic protocols is a constant need. Thiazolidinedione and chromone represent two important scaffolds in medicinal chemistry due to their large pharmacological applicability.Methods. We synthesized a new 5-(chromene-3-yl)methylene-2,4-thiazolidinedione starting from 6,8-dichloro-4-oxo-4H-chromene-3-carbaldehyde. Then, by treating with different α-bromoalkylarylketones, we obtained N-substituted derivatives. All new compounds were inve

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Pochat, Francis, and Paul L'Haridon. "New Substituted Derivatives of Benzopyran and Chromone." Synthetic Communications 28, no. 6 (1998): 957–62. http://dx.doi.org/10.1080/00397919808003064.

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Walenzyk, Thomas, Christophe Carola, Herwig Buchholz, and Burkhard König. "Chromone derivatives which bind to human hair." Tetrahedron 61, no. 31 (2005): 7366–77. http://dx.doi.org/10.1016/j.tet.2005.05.081.

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Kaye, Perry T., Aloysius T. Nchinda, Liezel V. Sabbagh, and John Bacsa. "Chromone Studies. Part 14.1 Unprecedented Dimerisation of Chromone-3-Carbaldehyde-Derived Baylis–Hillman Adducts." Journal of Chemical Research 2003, no. 3 (2003): 111–13. http://dx.doi.org/10.3184/030823403103173219.

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1,4-Diazabicyclo[2.2.2]octane (DABCO)-catalysed Baylis-Hillman reactions of selected chromone-3-carbaldehydes with methyl acrylate have been shown to afford mixtures of the expected Baylis-Hillman products and unprecedented dimeric derivatives. The Baylis–Hillman products, on heating at 80°C in the presence of DABCO, are converted to the corresponding dimers, the structures of which have been unambiguously established by NMR and X-ray crystallographic analysis. Electron-impact and electrospray MS data for the dimeric systems are discussed.

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PATONAY, T., A. LEVAI, L. HEGEDUES, and E. PATONAY-PELI. "ChemInform Abstract: Synthesis of Novel [(5H-Tetrazolyl)alkoxy]-Substituted Chromone and Chromanone Derivatives." ChemInform 29, no. 49 (2010): no. http://dx.doi.org/10.1002/chin.199849161.

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Yu, Meng, Yangyang Liu, Jian Feng, et al. "Remarkable Phytochemical Characteristics of Chi-Nan Agarwood Induced from New-Found Chi-Nan Germplasm of Aquilaria sinensis Compared with Ordinary Agarwood." International Journal of Analytical Chemistry 2021 (April 10, 2021): 1–10. http://dx.doi.org/10.1155/2021/5593730.

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Wild Chi-Nan agarwood is regarded as the highest quality agarwood from Aquilaria spp. However, the comprehensive research on chemical composition of wild Chi-Nan agarwood is limited. An integrated strategy using SHS-GC-MS and UPLC-Q/Tof-MS was applied to explore the phytochemical characteristics of a kind of agarwood induced from a newly identified germplasm of Chi-Nan A. sinensis. Progenesis QI and MS-Dial were used to preprocess the UPLC-Q/Tof-MS and GC-MS raw data, respectively. Principle component analysis (PCA) and orthogonal partial least squares to latent structure-discriminant analysis

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Shanker, M. S. S., R. B. Reddy, G. V. P. Chandra Mouli, and Y. D. Reddy. "SYNTHESIS AND CLEAVAGE REACTIONS OF BENZOTHIAZEPINYL CHROMONE DERIVATIVES." Phosphorus, Sulfur, and Silicon and the Related Elements 44, no. 1-2 (1989): 143–47. http://dx.doi.org/10.1080/10426508908043717.

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Oganesyan, �. T., A. S. Saraf, and A. V. Ivchenko. "Synthesis and antiallergic activity of novel chromone derivatives." Pharmaceutical Chemistry Journal 27, no. 1 (1993): 52–54. http://dx.doi.org/10.1007/bf00772853.

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Legoabe, Lesetja J., Anél Petzer, and Jacobus P. Petzer. "Selected chromone derivatives as inhibitors of monoamine oxidase." Bioorganic & Medicinal Chemistry Letters 22, no. 17 (2012): 5480–84. http://dx.doi.org/10.1016/j.bmcl.2012.07.025.

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Gomes, Ana, Ondrej Neuwirth, Marisa Freitas, et al. "Synthesis and antioxidant properties of new chromone derivatives." Bioorganic & Medicinal Chemistry 17, no. 20 (2009): 7218–26. http://dx.doi.org/10.1016/j.bmc.2009.08.056.

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Maicheen, Chirattikarn, Narumol Phosrithong, and Jiraporn Ungwitayatorn. "Docking study on anticancer activity of chromone derivatives." Medicinal Chemistry Research 22, no. 1 (2012): 45–56. http://dx.doi.org/10.1007/s00044-012-0009-y.

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Rukachaisirikul, Vatcharin, Sirinya Chantaruk, Wipapan Pongcharoen, Masahiko Isaka, and Sanisa Lapanun. "Chromone Derivatives from the Filamentous FungusLachnumsp. BCC 2424." Journal of Natural Products 69, no. 6 (2006): 980–82. http://dx.doi.org/10.1021/np060164e.

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