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Journal articles on the topic 'Chromonyl'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Berczyński, Paweł, Aleksandra Kładna, Irena Kruk, et al. "Antioxidant Activities of Some New Chromonyl-2,4-Thiazolidinediones and Chromonyl-2,4-Imidazolidinediones Having Chromone Cores." Journal of Fluorescence 23, no. 6 (2013): 1319–27. http://dx.doi.org/10.1007/s10895-013-1266-y.

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2

Hishmat, O. H., N. M. Fawzy, D. S. Farrag, and A. S. Abd El-All. "ChemInform Abstract: Aminolysis and Hydrolysis of Chromonyl Oxazolones Leading to New Chromones." ChemInform 31, no. 25 (2010): no. http://dx.doi.org/10.1002/chin.200025148.

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3

Modi, Karan, Scott Lawson, Guanglin Chen, et al. "1-Chromonyl-5-Imidazolylpentadienone Demonstrates Anti-Cancer Action against TNBC and Exhibits Synergism with Paclitaxel." International Journal of Molecular Sciences 21, no. 16 (2020): 5777. http://dx.doi.org/10.3390/ijms21165777.

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Curcumin has been well studied for its anti-oxidant, anti-inflammatory, and anti-cancer action. Its potential as a therapy is limited due to its low bioavailability and rapid metabolism. To overcome these challenges, investigators are developing curcumin analogs, nanoparticle formulations, and combining curcumin with other compounds or dietary components. In the present study, we used a 1-chromonyl-5-imidazolylpentadienone named KY-20-22 that contains both the pharmacophore of curcumin and 1,4 benzopyrone (chromone) moiety typical for flavonoids, and also included specific moieties to enhance

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4

Alizadeh, Abdolali, Akram Bagherinejad, Jasmine Kayanian, and Robert Vianello. "An expedient metal-free cascade route to chromonyl diene scaffolds: thermodynamic vs. kinetic control." RSC Advances 12, no. 54 (2022): 34946–50. http://dx.doi.org/10.1039/d2ra05704b.

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5

Lang, Si-Yao, Duo-Zhi Wang та Ling-Hua Cao. "Synthesis of Chromonyl-Containing α-Aminophosphonates". Phosphorus, Sulfur, and Silicon and the Related Elements 184, № 10 (2009): 2560–68. http://dx.doi.org/10.1080/10426500802529127.

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6

Verspohl, Eugen J., Oya Bozdağ-Dündar, Rebecca M. Kaup, Katrin Bauer, and Rahmiye Ertan. "Insulinotropic activity of chromonyl-2,4-thiazolidinediones." Medicinal Chemistry Research 18, no. 8 (2009): 665–70. http://dx.doi.org/10.1007/s00044-008-9158-4.

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7

M., S. S. SHANKAR, B. REDDY R., V. P. CHANDRA MOULl G., and D. REDDY Y. "Synthesis of a New Series of Chromonyl Chalcones." Journal of Indian Chemical Society Vol. 66, JAN 1989 (1989): 30–31. https://doi.org/10.5281/zenodo.5947752.

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Department of Chemistry, Regional Engineering College, Waranga.l-506 004. <em>Manuscript received 19 May 1988, </em>revised 23 <em>September 1988, accepted 4 October 1988</em> The  \(\propto\)β-unsaturated ketones (2 and 4) were prepared by the condensation of 3-formylchromone (1) or 8 acetyl-7-hydroxy-2,3-dimethylchromone (3) with substituted-acetophenones or different aromatic aldehydes. Structures of the compounds were established by their analytical and spectral data.

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8

Kumar, Kamal, Kathrin Wittstein, Ana García та Markus Schürmann. "Exploring α-Chromonyl Nitrones as 1,5-Dipoles". Synlett 2012, № 02 (2012): 227–32. http://dx.doi.org/10.1055/s-0031-1290070.

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9

Lévai, Albert, and József Jekö. "Synthesis of 3-aroyl-4-(3-chromonyl)-2-pyrazolines." Journal of Heterocyclic Chemistry 39, no. 6 (2002): 1333–36. http://dx.doi.org/10.1002/jhet.5570390636.

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10

Deharkar, Pravin, Shridhar Satpute, and Deepa Panhekar. "Synthetic Routes and Biological Activities of Chromone Scaffolds: An Overview." Asian Journal of Chemistry 35, no. 4 (2023): 771–93. http://dx.doi.org/10.14233/ajchem.2023.23442.

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The central backbones of natural assets and therapeutic medications are chromone and flavone. Utilizing such preferred chalcone analogs in drug research has shown a successful blueprint, yielding new hits/leads and fast optimization procedures. Chromone can create novel molecules with pharmacological promise, particularly in neurological, inflammatory, infectious diseases, cancer and diabetes. The current perspective focuses mainly on flavones and flavonoids of biological significance, such as chromon-4-one analogs, both synthetic and natural sources. Furthermore, because drug repurposing is n

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11

Ceylan-Ünlüsoy, Meltem, Eugen J. Verspohl, and Rahmiye Ertan. "Synthesis and antidiabetic activity of some new chromonyl-2,4-thiazolidinediones." Journal of Enzyme Inhibition and Medicinal Chemistry 25, no. 6 (2010): 784–89. http://dx.doi.org/10.3109/14756360903357544.

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12

Sharma, V. P., and Rakesh Kumar. "Synthesis, Characterization and Antimicrobial Screening of Some Novel Chromonyl Isoxazoles." Asian Journal of Research in Chemistry 12, no. 2 (2019): 116. http://dx.doi.org/10.5958/0974-4150.2019.00025.7.

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13

LACOVA, M., H. STANKOVICOVA, and Z. ODLEROVA. "ChemInform Abstract: Chromonyl-Aminosalicylic Acid Derivatives as Possible Antimycobacterial Agents." ChemInform 27, no. 22 (2010): no. http://dx.doi.org/10.1002/chin.199622147.

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14

Letulle, Cécile, François-Xavier Toublet, Aline Pinon, et al. "Synthesis and Antiproliferative Effect of 3,4,5-Trimethoxylated Chalcones on Colorectal and Prostatic Cancer Cells." Pharmaceuticals 17, no. 9 (2024): 1207. http://dx.doi.org/10.3390/ph17091207.

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In the context of designing innovative anticancer agents, the synthesis of a series of chalcones bearing a 3,4,5-trimethoxylated A ring and a variety of B rings, including phenols and original heterocycles such as chromones, was conducted. For this end, Claisen–Schmidt condensation was performed in basic or acidic conditions between the common starting material 3,4,5-trimethoxyacetophenone and appropriate aldehydes; this allowed the recovery of fifteen chalcones in moderate–good yields. The synthesized compounds were screened for their antiproliferative activity against colorectal and prostati

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15

Teimouri, Mohammad Bagher, Elham Batebi, Shabnam Mohammadnia, and Hamid Reza Khavasi. "Water-controlled selectivity switch in a multicomponent reaction: One-pot stereoselective synthesis of (acyloxymethylidene)chromonyl-furochromones and amido-(acyloxymethylidene)chromones." Tetrahedron 96 (September 2021): 132374. http://dx.doi.org/10.1016/j.tet.2021.132374.

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16

Bozdag-Dündar, Oya, Meltem Ceylan-Ünlüsoy, Eugen Verspohl, and Rahmiye Ertan. "Synthesis and Antidiabetic Activity of Some New Chromonyl-2,4-thiazo-lidinediones." Arzneimittelforschung 57, no. 08 (2011): 532–36. http://dx.doi.org/10.1055/s-0031-1296644.

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17

Santoso, Kristiana T., Matthew W. Brett, Chen‐Yi Cheung, Gregory M. Cook, Bridget L. Stocker, and Mattie S. M. Timmer. "Synthesis of Functionalised Chromonyl‐pyrimidines and Their Potential as Antimycobacterial Agents." ChemistrySelect 5, no. 14 (2020): 4347–55. http://dx.doi.org/10.1002/slct.202000799.

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18

Oganesyan, É. T., V. A. Tuskaev, L. S. Sarkisov, and A. S. Saraf. "Synthesis of 3-(3-chromonyl)acrylic acid derivatives and their antiallergic activity." Pharmaceutical Chemistry Journal 29, no. 10 (1995): 685–87. http://dx.doi.org/10.1007/bf02219526.

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19

Mendieta-Moctezuma, Aarón, Catalina Rugerio-Escalona, Nemesio Villa-Ruano та ін. "Synthesis and biological evaluation of novel chromonyl enaminones as α-glucosidase inhibitors". Medicinal Chemistry Research 28, № 6 (2019): 831–48. http://dx.doi.org/10.1007/s00044-019-02320-w.

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20

Teimouri, Mohammad Bagher, Foad Mashayekhi, and Elham Alishaei. "Synthesis of 2-(3-chromonyl)-2-acyloxycarboxamides via multicomponent reactions of isocyanides." Journal of the Iranian Chemical Society 13, no. 3 (2015): 583–90. http://dx.doi.org/10.1007/s13738-015-0769-7.

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21

Bozdağ-Dündar, Oya, Begüm Evranos, Net Daş-Evcimen, Mutlu Sarıkaya, and Rahmiye Ertan. "Synthesis and aldose reductase inhibitory activity of some new chromonyl-2,4-thiazolidinediones." European Journal of Medicinal Chemistry 43, no. 11 (2008): 2412–17. http://dx.doi.org/10.1016/j.ejmech.2008.01.004.

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22

Kruk, Irena, Oya Bozdağ-Dündar, Rahmiye Ertan, Hassan Y. Aboul-Enein, and Teresa Michalska. "Hydroxyl and superoxide radical scavenging abilities of chromonyl-thiazolidine-2,4-dione compounds." Luminescence 24, no. 2 (2009): 96–101. http://dx.doi.org/10.1002/bio.1077.

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23

Miliutina, Mariia, Syeda Abida Ejaz, Viktor O. Iaroshenko, Alexander Villinger, Jamshed Iqbal, and Peter Langer. "Synthesis of 3,3′-carbonyl-bis(chromones) and their activity as mammalian alkaline phosphatase inhibitors." Organic & Biomolecular Chemistry 14, no. 2 (2016): 495–502. http://dx.doi.org/10.1039/c5ob01350j.

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Hitherto unknown 3,3′-carbonyl-bis(chromones) 8, dimeric chromones bridged by a carbonyl group, were prepared by reaction of chromone-3-carboxylic acid chloride with 3-(dimethylamino)-1-(2-hydroxyphenyl)-2-propen-1-ones 9.

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24

Ozen, Cigdem, Meltem Ceylan-Unlusoy, Mehmet Ozturk, and Oya Bozdag-Dundar. "A novel chromonyl thiohydantoin with anti-proliferative action on primary hepatocellular carcinoma cells." Medicinal Chemistry Research 27, no. 1 (2017): 153–60. http://dx.doi.org/10.1007/s00044-017-2037-0.

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25

Mrug, Galyna, and Mykhaylo Frasinyuk. "Advances in chemistry of chromone aminomethyl derivatives." French-Ukrainian Journal of Chemistry 3, no. 2 (2015): 21–39. http://dx.doi.org/10.17721/fujcv3i2p21-39.

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Chromones play an important role in the design and discovery of new pharmacologically active compounds. A large volume of reports dedicated to synthesis and study of properties of nitrogen-containing chromone derivatives show important role of chromone alkaloid-like compounds. The present review covers achievements in the field of synthesis of chromone aminomethyl derivatives as one of perspective scaffolds.

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26

Cho, Y. M. "Quark and Chromon Model and Glueball-Quarkonium Mixing in QCD." EPJ Web of Conferences 182 (2018): 02031. http://dx.doi.org/10.1051/epjconf/201818202031.

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The existence of two types of gluons in QCD, the color neutral neurons and colored chromons, implies that the chromons can be the constituent of hadrons. This generalizes the quark model to the quark and chromon model. We discuss the glueballquarkonium mixing in QCD based on the quark and chromon model. We present the neumerical analysis of glueball-quarkonium mixing below 2 GeV in 0++, 2++, and 0-+ channels, and predict the relative branching ratios of the radiative decay of to the physical states.

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27

Wang, Xiaohong, Menglin Peng, Yijin Wang та ін. "Eco-Friendly and Efficient Synthesis of 2-Hydroxy-3-Hydrazono-Chromones Through α,β-C(sp2)–H Bond Difunctionalization/Chromone Annulation Reaction of o-Hydroxyaryl Enaminones, Water, and Aryldiazonium Salts". Molecules 30, № 6 (2025): 1194. https://doi.org/10.3390/molecules30061194.

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A novel, eco-friendly, and efficient method for constructing 2,3-disubstituted chromone skeletons from readily available water, o-hydroxyaryl enaminones (o-HPEs), and aryldiazonium salts has been developed under mild reaction conditions. This α,β-C(sp2)–H bond difunctionalization/chromone annulation reaction strategy is achieved by building two C(sp3)–O bonds and a C(sp2)-N bond, which provides a practical pathway for the preparation of 2-hydroxy-3-hydrazono-chromones in moderate to excellent yields, enabling broad substrate scope and good functional group tolerance, as well as gram-scale synt

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28

Ramadan, Sayed K., and Eman A. E. El-Helw. "Synthesis and Antimicrobial Activity Evaluation of Some Novel Heterocycles Derived from Chromonyl-2(3H)-furanone." Journal of Chemical Research 42, no. 6 (2018): 332–36. http://dx.doi.org/10.3184/174751918x15295796734379.

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6-Chloro-3-((2-oxo-5-phenylfuran-3(2 H)-ylidene)methyl)-4 H-chromen-4-one was utilised for the construction of N-heterocycles. The proclivity of this furanone towards some nitrogen nucleophiles, i.e. glycine, thiosemicarbazide, thiocarbohydrazide, phenylhydrazine and o-phenylenediamine, was studied. The structures of all products obtained were established on the basis of their analytical and spectral data. All synthesised compounds were screened for their in vitro antibacterial (two strains of bacteria; Escherichia coli and Staphylococcus aureus) and antifungal (two fungus strains; Aspergillus

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29

Siddiqui, Zeba N., Shagufta Praveen, T. N. Mohammed Musthafa, Anis Ahmad, and Asad U. Khan. "Thermal solvent-free synthesis of chromonyl chalcones, pyrazolines and their in vitro antibacterial, antifungal activities." Journal of Enzyme Inhibition and Medicinal Chemistry 27, no. 1 (2011): 84–91. http://dx.doi.org/10.3109/14756366.2011.577035.

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30

Özlem; AMİRZADEH-KHİABANİ, YILDIRIM. "Alterations of aldose reductase and superoxide dismutase activities by some chromonyl-2, 4-thiazolidinedione derivatives." Ankara Üniversitesi Veteriner Fakültesi Dergisi 61, no. 4 (2014): 249–54. http://dx.doi.org/10.1501/vetfak_0000002638.

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31

Abass, Mohamed, Mohamed Abdel‐Megid, and Mohamed Hassan. "Substituted Quinolinones, Part 12: Heterocyclization Reactions of 3‐(3‐Chromonyl)acryloylquinolinone with Some Bifunctional Nucleophiles." Synthetic Communications 37, no. 2 (2007): 329–52. http://dx.doi.org/10.1080/00397910601033930.

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32

El-Ziaty, Ahmed K., Wael S. I. Abou-Elmagd, Sayed K. Ramadan, and Ahmed I. Hashem. "Synthesis and biological screening of some chromonyl-substituted heterocycles derived from 2(3H)-furanone derivative." Synthetic Communications 47, no. 5 (2017): 471–80. http://dx.doi.org/10.1080/00397911.2016.1271896.

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33

Yamaguchi, Seiji, Masao Mutoh, Masaaki Shimakura, Kunihiro Tsuzuki та Yoshiyuki Kawase. "Some fatty acids having anO-heterocycle in their terminal positions.I. ω-(3-Chromonyl)alkanoic acids". Journal of Heterocyclic Chemistry 28, № 1 (1991): 119–23. http://dx.doi.org/10.1002/jhet.5570280121.

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34

Samar, Ghosh, and Pratim Maiti Partha. "APPLICATIONS OF CHROMONES: RECENT TRENDS." International Journal of Advance and Applied Research 3, no. 4 (2023): 115–25. https://doi.org/10.5281/zenodo.7654046.

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The rigid bicyclic chromone fragment has been classified as a privileged structure in drug discovery, due to its use in a wide variety of pharmacologically active compounds; few examples as therapeutic agents chromones are used as scaffolds for the development of bioactive compounds, the application in medicinal chemistry, such as preparation of fluorescence probes, due to photochemical properties of chromones have been also mentioned.

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35

Yu, Qing, Yunyun Liu, and Jie-Ping Wan. "Transition metal-free synthesis of 3-trifluoromethyl chromones via tandem C–H trifluoromethylation and chromone annulation of enaminones." Organic Chemistry Frontiers 7, no. 18 (2020): 2770–75. http://dx.doi.org/10.1039/d0qo00855a.

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The synthesis of 3-trifluoromethyl chromones has been realized via transition metal-free reactions of o-hydroxyphenyl enaminones and the Langlois reagent via cascade C–H trifluoromethylation and chromone annulation.

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36

Benny, Anjitha Theres, and Ethiraj Kannatt Radhakrishnan. "Advances in the site-selective C-5, C-3 and C-2 functionalization of chromones via sp² C–H activation." RSC Advances 12, no. 6 (2022): 3343–58. http://dx.doi.org/10.1039/d1ra08214k.

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37

Lei, Jie, Yong Li, Liu-Jun He, et al. "Expeditious access of chromone analogues via a Michael addition-driven multicomponent reaction." Organic Chemistry Frontiers 7, no. 8 (2020): 987–92. http://dx.doi.org/10.1039/d0qo00145g.

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A Michael addition-driven four-component reaction (4-CR) with four Ugi inputs was developed and utilized for the synthesis of chromone derivatives and tetrazole substituted chromones under mild reaction conditions.

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38

Luo, Tian, Jie-Ping Wan та Yunyun Liu. "Toward C2-nitrogenated chromones by copper-catalyzed β-C(sp2)–H N-heteroarylation of enaminones". Organic Chemistry Frontiers 7, № 9 (2020): 1107–12. http://dx.doi.org/10.1039/d0qo00065e.

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The synthesis of C2-nitrogenated chromones has been performed via reactions of enaminones and nitrogen nucleophiles based on an unconventional β-C–H bond functionalization and a featured chromone annulation of enaminones.

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39

Rao, B. Kanakadurga, and Y. Jayaprakash Rao. "An Efficient and Facile Synthesis of Novel Triazole C-N Linked Chromone Hybrids." Asian Journal of Chemistry 32, no. 7 (2020): 1806–8. http://dx.doi.org/10.14233/ajchem.2020.22734.

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A series of new C3-N1 directly linked chromone/1,2,3-triazole molecular hybrids synthesized by adopting low cost effective CuI catalyzed azide-alkyne 1,3-dipolar cycloaddition (Cu-AAC triazole annulation) from chromone-3-aldehyde via key intermediates 3-azidochromone, synthesized from another intermediate 3-hydroxychromone. These synthetic 1,2,3-triazole embedded chromones are the new addition to the click chemistry family. The structures of final products established by IR, NMR and mass spectral analysis.

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40

Stoermer, MJ, and DP Fairlie. "A Selective and Versatile Synthesis of Substituted Chromones via Addition of Phenols to Dimethyl Acetylenedicarboxylate." Australian Journal of Chemistry 48, no. 3 (1995): 677. http://dx.doi.org/10.1071/ch9950677.

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Despite many published syntheses of chromones, none has been reported to be both selective for chromones and tolerant of ring substitution. The addition of substituted phenols to dimethyl acetylenedicarboxylate is now reported as a versatile high yield initial step in a simple three-step synthesis of chromone 2-carboxylic acids. Triethylamine being used to deprotonate the substituted phenol, the addition to dimethyl acetylenedicarboxylate proceeds under mild conditions and tolerates a wide range of functional groups on the phenol. Although not stereoselective, both fumarate and maleate aryloxy

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41

E. Ali, Tarik, Salah A. Abdel-Aziz, Somaya M. El-Edfawy, El-Hossain A. Mohamed, and Somaia M. Abdel-Kariem. "SYNTHESIS AND BIOLOGICAL EVALUATIONS OF A SERIES OF NOVEL AZOLYL, AZINYL, PYRANYL, CHROMONYL AND AZEPINYL PHOSPHONATES." HETEROCYCLES 87, no. 12 (2013): 2513. http://dx.doi.org/10.3987/com-13-12836.

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42

Sugiyama, Takuji, Yuji Narukawa, Shunsuke Shibata, Ryo Masui, and Fumiyuki Kiuchi. "New 2-(2-Phenylethyl)chromone Derivatives and Inhibitors of Phosphodiesterase (PDE) 3A from Agarwood." Natural Product Communications 11, no. 6 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100624.

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The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6,8-dihydroxy-2-[2-(4′-methoxyphenyl)ethyl]chromone (6), and 6,7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3 A inhibitory activity with IC50 of 4.83 μM.

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43

Guo, Yanhui, Shanshan Zhong, Li Wei, and Jie-Ping Wan. "Transition-metal-free synthesis of 3-sulfenylated chromones via KIO3-catalyzed radical C(sp2)–H sulfenylation." Beilstein Journal of Organic Chemistry 13 (September 27, 2017): 2017–22. http://dx.doi.org/10.3762/bjoc.13.199.

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The reactions between o-hydroxylphenyl-functionalized enaminones and sulfonyl hydrazines providing 3-sulfenylated chromones via domino chromone ring construction and C(sp2)–H bond sulfenylation have been achieved under transition-metal-free conditions by using KIO3 as the only catalyst.

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44

Hammadi, Mohamed, Oualid Talhi, Artur Silva, et al. "Regioselective and Catalyst-Free Epoxidation of (E)-3-[3-(2-Hydroxyaryl)-3-oxoprop-1-en-1-yl]chromones." Synlett 29, no. 20 (2018): 2633–37. http://dx.doi.org/10.1055/s-0037-1611082.

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The uncatalyzed reaction of hydrogen peroxide with (E)-3-[3-(2-hydroxyaryl)-3-oxoprop-1-en-1-yl]chromones resulted in a regioselective epoxidation of the chromone intracyclic C(2)=C(3) double bond to afford unique isomeric (E)-7a-[3-(2-hydroxyphenyl)-3-oxoprop-1-en-1-yl]-1aH-oxireno[2,3-b]chromen-7(7aH)-ones in high yields. 2D NMR and single-crystal X-ray diffraction were used to elucidate the structures of the chromanone epoxides. Density functional theoretical studies demonstrated a high electrophilicity of the starting chromones.

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45

Kumar, Kamal, Vivek Khedkar, Wei Liu та Heiko Dückert. "Efficient and Atom-Economic Synthesis of α-Substituted β-Chromonyl-α,β-unsaturated Carbonyls through Molecular Rearrangement". Synlett 2010, № 03 (2010): 403–6. http://dx.doi.org/10.1055/s-0029-1219176.

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46

Kumar, Kamal, Vivek Khedkar, Wei Liu та Heiko Dückert. "Efficient and Atom-Economic Synthesis of α-Substituted β-Chromonyl-α,β-unsaturated Carbonyls through Molecular Rearrangement". Synlett 2010, № 10 (2010): 1576. http://dx.doi.org/10.1055/s-0029-1219954.

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47

Siddiqui, Zeba N., and T. N. Mohammed Musthafa. "An efficient and novel synthesis of chromonyl chalcones using recyclable Zn(l-proline)2 catalyst in water." Tetrahedron Letters 52, no. 31 (2011): 4008–13. http://dx.doi.org/10.1016/j.tetlet.2011.05.118.

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48

Jamaati, Hoda, Saeed Balalaie, Maryam Kazemi Miraki, Frank Rominger, and Hamid Reza Bijanzadeh. "Choline Chloride/ Urea as Mild Media for the Synthesis of the Chromonyl Amidodiester Fragments and Succinimide Derivatives." ChemistrySelect 4, no. 31 (2019): 9074–78. http://dx.doi.org/10.1002/slct.201901893.

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49

Boutoute, Patrick, and Guy Mousset. "Réduction électrochimique régiosélective d'aroyl-2- ou d'acetyl-2 chromones en milieu non aqueux." Canadian Journal of Chemistry 70, no. 8 (1992): 2266–75. http://dx.doi.org/10.1139/v92-285.

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The electrochemical behaviour of chromones substituted in position 2 by benzoyl or acetyl groups was studied by cyclic voltammetry in a nonaqueous solvent. Self-protonation reactions were observed with compounds possessing a phenol function on the benzoyl group. Macroelectrolyses achieved in the presence of a proton donor afford a regioselective reduction of the carbonyl function in position 2 of the benzoyl-2 chromone and of the double bond for the acetyl-2 chromone. Moreover the further reduction leads to the formation of thermally unstable dimers, which may give homolytic cleavage to free r

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50

Benny, Anjitha Theres, Sonia D. Arikkatt, Cijo George Vazhappilly, et al. "Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity." Mini-Reviews in Medicinal Chemistry 22, no. 7 (2022): 1030–63. http://dx.doi.org/10.2174/1389557521666211124141859.

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: Chromones are the class of secondary metabolites that broadly occur in the plant kingdom in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged scaffolds in compounds” in medicinal chemistry. Their wide biological responses have made them an important moiety in a drug discovery program. This review provides updates on the various methods of synthesis of chromones and biological applications in medicinal chemistry. Various synthetic strategies for the construction of chromones include readily available phenols, salicylic acid and its derivatives, ynones, chal

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