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Relevant bibliographies by topics / Chromosome breakage

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Academic literature on the topic 'Chromosome breakage'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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Journal articles on the topic "Chromosome breakage"

1

Spell, R. M., and C. Holm. "Nature and distribution of chromosomal intertwinings in Saccharomyces cerevisiae." Molecular and Cellular Biology 14, no. 2 (1994): 1465–76. http://dx.doi.org/10.1128/mcb.14.2.1465.

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To elucidate yeast chromosome structure and behavior, we examined the breakage of entangled chromosomes in DNA topoisomerase II mutants by hybridization to chromosomal DNA resolved by pulsed-field gel electrophoresis. Our study reveals that large and small chromosomes differ in the nature and distribution of their intertwinings. Probes to large chromosomes (450 kb or larger) detect chromosome breakage, but probes to small chromosomes (380 kb or smaller) reveal no breakage products. Examination of chromosomes with one small arm and one large arm suggests that the two arms behave independently.

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Spell, R. M., and C. Holm. "Nature and distribution of chromosomal intertwinings in Saccharomyces cerevisiae." Molecular and Cellular Biology 14, no. 2 (1994): 1465–76. http://dx.doi.org/10.1128/mcb.14.2.1465-1476.1994.

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To elucidate yeast chromosome structure and behavior, we examined the breakage of entangled chromosomes in DNA topoisomerase II mutants by hybridization to chromosomal DNA resolved by pulsed-field gel electrophoresis. Our study reveals that large and small chromosomes differ in the nature and distribution of their intertwinings. Probes to large chromosomes (450 kb or larger) detect chromosome breakage, but probes to small chromosomes (380 kb or smaller) reveal no breakage products. Examination of chromosomes with one small arm and one large arm suggests that the two arms behave independently.

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3

Fluminhan, A., and T. Kameya. "Involvement of knob heterochromatin in mitotic abnormalities in germinating aged seeds of maize." Genome 40, no. 1 (1997): 91–98. http://dx.doi.org/10.1139/g97-012.

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Seeds of three inbred lines of maize, with contrasting numbers of heterochromatic knobs and stored under two different ageing treatments, were analyzed for the occurrence of abnormalities at mitotic anaphase in root meristems 3, 7, 21,42, and 56 days after germination, and in root meristems of their freshly harvested selfed progeny. The largest category of detectable aberrations involved breakage of knobbed chromosome arms. We have obtained evidence that knob heterochromatin plays a central role in the origin of primary chromosome bridges. The initial event responsible for the occurrence of br

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4

Hamilton, Eileen P., Sondra Williamson, Sandra Dunn, et al. "The Highly Conserved Family of Tetrahymena thermophila Chromosome Breakage Elements Contains an Invariant 10-Base-Pair Core." Eukaryotic Cell 5, no. 4 (2006): 771–80. http://dx.doi.org/10.1128/ec.5.4.771-780.2006.

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ABSTRACT As a typical ciliate, Tetrahymena thermophila is a unicellular eukaryote that exhibits nuclear dimorphism: each cell contains a diploid, germ line micronucleus (MICN) and a polyploid, somatic macronucleus (MACN). During conjugation, when a new MACN differentiates from a mitotic descendant of the diploid fertilization nucleus, the five MICN chromosomes are site-specifically fragmented into 250 to 300 MACN chromosomes. The classic chromosome breakage sequence (CBS) is a 15-bp element (TAAACCAACCTCTTT) reported to be necessary and sufficient for chromosome breakage. To determine whether

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Dooner, H. K., and A. Belachew. "Chromosome breakage by pairs of closely linked transposable elements of the Ac-Ds family in maize." Genetics 129, no. 3 (1991): 855–62. http://dx.doi.org/10.1093/genetics/129.3.855.

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Abstract Chromosome breaks and hence chromosomal rearrangements often occur in maize stocks harboring transposable elements (TEs), yet it is not clear what types of TE structures promote breakage. We have shown previously that chromosomes containing a complex transposon structure consisting of an Ac (Activator) element closely linked in direct orientation to a terminally deleted or fractured Ac (fAc) element have a strong tendency to break during endosperm development. Here we show that pairs of closely linked transposons with intact ends, either two Ac elements--a common product of Ac transpo

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Tamar, Samira, and Barbara Papadopoulou. "A Telomere-mediated Chromosome Fragmentation Approach to Assess Mitotic Stability and Ploidy Alterations ofLeishmaniaChromosomes." Journal of Biological Chemistry 276, no. 15 (2001): 11662–73. http://dx.doi.org/10.1074/jbc.m009006200.

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We have used a telomere-associated chromosome fragmentation strategy to induce internal chromosome-specific breakage ofLeishmaniachromosomes. The integration of telomeric repeats from the kinetoplastidTrypanosoma bruceiinto defined positions of theLeishmaniagenome by homologous recombination can induce chromosome breakage accompanied by the deletion of the chromosomal part that is distal to the site of the break. The cloned telomeric DNA at the end of the truncated chromosomes is functional and it can seed the formation of new telomeric repeats. We found that genome ploidy is often altered upo

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Ta, Lan, Adrian Zordan, Bruce Mercer, Lynda J. Campbell, and Ruth N. MacKinnon. "The Breakage-Fusion-Bridge Cycle Producing MLL Amplification in a Case of Myelodysplastic Syndrome." Journal of Cancer Research 2013 (July 18, 2013): 1–6. http://dx.doi.org/10.1155/2013/452809.

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Telomere loss may lead to chromosomal instability via the breakage-fusion-bridge (BFB) cycle which can result in genetic amplification and the formation of ring and dicentric chromosomes. This cycle continues until stable chromosomes are formed. The case of a 72-year-old female with refractory anaemia with excess blasts type 2 illustrates these events. Conventional cytogenetics produced a complex karyotype which included unstable abnormalities of chromosomes 11, 12, and 15. Fluorescence in situ hybridization (FISH) analyses including multicolor-FISH (M-FISH) and multicolor-banding (M-BAND) rev

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McKim, Kim S., and Ann M. Rose. "Spontaneous duplication loss and breakage in Caenorhabditis elegans." Genome 37, no. 4 (1994): 595–606. http://dx.doi.org/10.1139/g94-085.

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Duplications in Caenorhabditis elegans spontaneously delete at frequencies ranging from 10−4 to 10−5. We have analyzed the structure and mitotic stability of 33 deleted duplications resulting from spontaneous breakage events. (i) Breakage usually occurred at a variety of sites; that is, there were no hot spots for breakage. An exception was the spontaneous breakage of the X chromosome into which hDp14 was inserted. These breaks were close to or at the site of the chromosome I insertion; therefore, the insertion created a type of fragile site. (ii) Spontaneous duplications often had complex str

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Deckbar, Dorothee, Julie Birraux, Andrea Krempler, et al. "Chromosome breakage after G2 checkpoint release." Journal of Cell Biology 176, no. 6 (2007): 749–55. http://dx.doi.org/10.1083/jcb.200612047.

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DNA double-strand break (DSB) repair and checkpoint control represent distinct mechanisms to reduce chromosomal instability. Ataxia telangiectasia (A-T) cells have checkpoint arrest and DSB repair defects. We examine the efficiency and interplay of ATM's G2 checkpoint and repair functions. Artemis cells manifest a repair defect identical and epistatic to A-T but show proficient checkpoint responses. Only a few G2 cells enter mitosis within 4 h after irradiation with 1 Gy but manifest multiple chromosome breaks. Most checkpoint-proficient cells arrest at the G2/M checkpoint, with the length of

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Nasuda, Shuhei, Bernd Friebe, and Bikram S. Gill. "Gametocidal Genes Induce Chromosome Breakage in the Interphase Prior to the First Mitotic Cell Division of the Male Gametophyte in Wheat." Genetics 149, no. 2 (1998): 1115–24. http://dx.doi.org/10.1093/genetics/149.2.1115.

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Abstract Male gametogenesis was cytologically analyzed in wheat lines homozygous or hemizygous for gametocidal (Gc) factors with different modes of action. The first and second meiotic divisions in all lines were cytologically normal. The postmeiotic mitoses were normal in the homozygous lines; however, chromosome fragments and bridges were observed in the mitoses of the hemizygous lines. The morphology of the chromosome fragments suggests that the Gc genes induce chromosome breaks in the G1 phase prior to DNA synthesis of the first postmeiotic mitosis. The age of an anther was correlated with

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Dissertations / Theses on the topic "Chromosome breakage"

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Brown, Karen E. "Telomere-directed breakage of the human Y chromosome." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260731.

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Barwell, Julian Grosvenor. "Chromosome breakage and apoptosis in breast cancer susceptibility." Thesis, St George's, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429197.

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Heyse, Serena R. "Functional divergence between Tetrahymena telomere proteins: Potential role for POT1b in chromosome breakage and new telomere synthesis." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1299168952.

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English, James J. "Elucidation of mechanisms by which maize Ac and Ds elements induce chromosome breakage." Thesis, University of East Anglia, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357252.

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Cranert, Stacey. "The functional evolution of telomere proteins in Tetrahymena thermophila." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1415283984.

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Tapia, Páez Isabel. "Characterization of human chromosome 22 : cloning of breakpoints of the constitutional translocation t(11;22)(q23;q11) and detection of small constitutional deletions by microarray CGH /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-505-0.

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Behnfeldt, Julia. "Chk2 phosphorylation of the BLM helicase promotes its interactions with topoisomerase IIa and the resolution of chromosome breakage." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429263006.

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Degerman, Sofie. "The immortalization process of T cells with focus on the regulation of telomere length and telomerase activity /." Doctoral thesis, Umeå : Umeå University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33466.

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Russell, Beatriz. "Interactions with topoisomerase IIa enhance the unwinding activity of the BLM helicase on recombination substrates and are necessary for preventing chromosome breakage." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1250676966.

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Beyer, Tracey Elaine, and Tracey Elaine Beyer. "Ontogeny of Unstable Chromosomes Formed by Telomere Replication Error." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/621103.

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The integrity of the genome relies on the maintenance of chromosomes, the structural embodiment of the genetic material. Disruption of chromosome replication can lead to extensive genomic rearrangements, spanning kilobase (Kb) to megabase (Mb) regions. Some chromosome rearrangements are inherently dynamic, beginning as a single unstable rearrangement from which multiple rearrangements emerge. The rare formation and transient behavior of unstable chromosomes renders their study challenging. Here I characterize the genetic ontogeny of unstable chromosomes in a budding yeast model, from initial r

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Books on the topic "Chromosome breakage"

1

English, James J. Elucidation of mechanisms by which maize Ac and Ds elements induce chromosome breakage. University of East Anglia, 1993.

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2

McKinlay Gardner, R. J., and David J. Amor. Chromosome Instability Syndromes. Edited by R. J. McKinlay Gardner and David J. Amor. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199329007.003.0016.

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A defect of DNA repair is the factor underlying the chromosome instability syndromes, also known as chromosome breakage syndromes. The “instability” refers to the predisposition of the chromosomes to undergo rearrangement or to display other abnormal cytogenetic behavior. The classic chromosome instability syndromes are individually rare: Fanconi syndrome, ataxia-telangiectasia, and Bloom syndrome. Smaller-print conditions are yet more rare, including Roberts syndrome; the immunodeficiency, centromeric instability, facial anomalies (ICF) syndrome; and Nijmegen breakage syndrome. The role of cy

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Book chapters on the topic "Chromosome breakage"

1

Therman, Eeva. "Chromosome Breakage Syndromes." In Human Chromosomes. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-0269-8_9.

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Therman, Eeva, and Millard Susman. "Causes of Chromosome Breakage." In Human Chromosomes. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4684-0529-3_10.

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3

Eastmond, D. A., D. S. Rupa, H. W. Chen, and L. Hasegawa. "Multicolor Fluorescence In Situ Hybridization with Centromeric DNA Probes as a New Approach to Distinguish Chromosome Breakage from Aneuploidy in Interphase Cells and Micronuclei." In Chromosome Segregation and Aneuploidy. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-84938-1_30.

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Nelsen, Birgit, R. Garber, E. Tillmann, and Hans-Peter Döring. "The Maize Transposable Element Ds as a Site for Chromosome Breakage." In Plant Molecular Biology. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4615-7598-6_93.

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Khan, S. H., and I. Emerit. "Conjugated Dienes and TBA Reactive Material as Components of Chromosome Breakage Factors." In Radiation Carcinogenesis and DNA Alterations. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5269-3_21.

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6

Joenje, H., and J. J. P. Gille. "Oxygen Metabolism and Chromosomal Breakage in Fanconi Anemia." In Fanconi Anemia. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74179-1_14.

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Demongeot, Jacques, Juglio Aracena, Samia Ben Lamine, Marie-Ange Mermet, and Olivier Cohen. "Hot Spots in Chromosomal Breakage: From Description TC Etiology." In Comparative Genomics. Springer Netherlands, 2000. http://dx.doi.org/10.1007/978-94-011-4309-7_8.

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Yamada, Takatomi, Hiroshi Murakami, and Kunihiro Ohta. "Pulsed-Field Gel Electrophoresis for Detecting Chromosomal DNA Breakage in Fission Yeast." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0323-9_12.

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Berger, R., and M. Le Coniat. "Cytogenetic Studies in Fanconi Anemia: Induced Chromosomal Breakage and Cytogenetics of Leukemia." In Fanconi Anemia. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74179-1_8.

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Ait Saada, Anissia, Alex B. Costa, and Kirill S. Lobachev. "Genetic and Molecular Approaches to Study Chromosomal Breakage at Secondary Structure–Forming Repeats." In Homologous Recombination. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0644-5_6.

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Conference papers on the topic "Chromosome breakage"

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Fooladi, Somaye, Hamid Khaloozadeh, and Farkhondeh Behjati. "Detection of increased level of chromosome breakage in peripheral blood of Iranian women with sporadic breast cancer using neural networks." In 2008 International Conference on Machine Learning and Cybernetics (ICMLC). IEEE, 2008. http://dx.doi.org/10.1109/icmlc.2008.4620592.

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Burman, Bharat, Zhuzhu Zhang, Rebecca Burgess, Vassilis Roukos, Jason Lieb, and Tom Misteli. "Abstract 2406: Epigenetics of chromosomal breakage sites and translocations." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2406.

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