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Journal articles on the topic 'Chronic atrophic candidiasis'
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Khan, TaiminazMohammad Sharif, FarahnazD Muddebihal, and AjitVarghese Koshy. "Chronic atrophic candidiasis: A case report and review of literature." Universal Research Journal of Dentistry 5, no. 2 (2015): 123. http://dx.doi.org/10.4103/2249-9725.157755.
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Rahman, M. Hasibur, Md Hadiuzzaman, Nahida Islam, Md Shahidul Islam, Sabrina Alam Mumu, and Atia Sharmin. "Oral candidiasis - Perleche Mimicking Malignancy." Community Based Medical Journal 3, no. 1 (February 10, 2014): 53–55. http://dx.doi.org/10.3329/cbmj.v3i1.53330.
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Candida species inhabit the mucosal surfaces of healthy individuals. Major forms of oral candidiasis are pseudomembranous and atrophic form, but chronic hyperplastic candidiasis (CHC) is rarely seen. We encountered a case of whitish plaque with nodule and ulceration. When an intraoral nodule is observed, the possibility of CHC should be taken into consideration. Biopsy of the lesion failed to show any signs of malignancy, and patient responded well to oral fluconazole therapy only.
CBMJ 2014 January: Vol. 03 No. 01 P: 53-55
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Aly, F. Z., C. C. Blackwell, D. A. C. MacKenzie, D. M. Weir, R. A. Elton, C. G. Cumming, J. A. Sofaer, and B. F. Clarke. "Chronic atrophic oral candidiasis among patients with diabetes mellitus – role of secretor status." Epidemiology and Infection 106, no. 2 (April 1991): 355–63. http://dx.doi.org/10.1017/s0950268800048500.
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SUMMARYNon-diabetic individuals who are non-secretors of blood group antigens are prone to superficial infections by Candida albicans. In this study, 216 patients with diabetes mellitus who were denture wearers were examined for the presence or absence of denture stomatitis. There was an overall trend for non-secretors to be prone to denture stomatitis compared with secretors. Stepwise linear discriminant analysis was used to dissect the contribution of secretor status and other variables to the development of the disease. Secretor status was found to be a contributory factor among patients with non-insulin dependent diabetes but not among those with insulin-dependent diabetes. The possible reasons for this are discussed.
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Lund, Rafael Guerra, Patrícia da Silva Nascente, Adriana Etges, Gladis Aver Ribeiro, Pedro Luiz Rosalen, and Francisco Augusto Burkert Del Pino. "Occurrence, isolation and differentiation ofCandidaspp. and prevalence of variables associated to chronic atrophic candidiasis." Mycoses 53, no. 3 (May 2010): 232–38. http://dx.doi.org/10.1111/j.1439-0507.2009.01697.x.
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YAN, ZHIMIN, ANDREW L. YOUNG, HONG HUA, and YANYING XU. "Multiple OralCandidaInfections in Patients with Sjögren’s Syndrome — Prevalence and Clinical and Drug Susceptibility Profiles." Journal of Rheumatology 38, no. 11 (August 15, 2011): 2428–31. http://dx.doi.org/10.3899/jrheum.100819.
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Objective.To determine the prevalence of oral candidiasis and multiple oralCandidainfections in patients with primary Sjögren’s syndrome (SS), and the clinical and drug susceptibility profile.Methods.Thirty patients with primary SS were enrolled in our study. The diagnosis of oral candidiasis was based on the clinical manifestation, and confirmed by a concentrated rinse culture.Candidaspp. assessment was accomplished using standard methods: Sabouraud dextrose agar with 50 mg/l chloramphenicol and CHROMagar were used for the rapid screening of clinical species, followed by the API 20C system for further species identification.In vitroantifungal drug susceptibility ofCandidaisolates was determined by the minimal inhibitory concentrations.Results.In our study, 87% (26/30) of subjects had oral candidiasis, in which 42% (11/26) had multipleCandidaspp. infection. AlthoughC. albicansremains the predominant isolate, other rare species such asC. tropicalis,C. glabrata,C. parapsilosis, andC. kruseiwere present, alone or in combination. Chronic atrophic candidiasis is the most common clinical type of oral candidiasis in patients with SS. The susceptibilities of the 44Candidaisolates to 7 antifungal agents varied dramatically. The resistance to azoles was remarkable, and the phenomenon of cross-resistance between itraconazole and fluconazole was observed.Conclusion.Patients with primary SS carry a high risk of oral candidiasis and a high frequency of multipleCandidainfections. The azole resistance patterns ofCandidaspp. support the necessity for drug susceptibility testing as a routine procedure for patients with oralCandidainfections.
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Reinhardt, L. C., P. S. Nascente, J. S. Ribeiro, V. B. S. Guimarães, A. Etges, and R. G. Lund. "Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC)." Brazilian Journal of Biology 80, no. 2 (June 2020): 266–72. http://dx.doi.org/10.1590/1519-6984.190454.
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Abstract The treatment of choice for chronic atrophic candidiasis (CAC), also known as denture stomatitis, is topical antifungal therapy. This study aimed to isolate, identify, and assess the antifungal susceptibility of Candida species from mucosal sites in denture wearers with a diagnosis of CAC and determine the prevalence of associated variables. The sample consisted of 44 patients wearing complete or partial dentures who had a clinical diagnosis of CAC. Using sterile cotton swabs, specimens were collected from the oral mucosa of all patients and grown at 30ºC for 48 h in CHROMagar Candida, as a means of isolating and screening the species. The complementary identification of the species was performed using the VITEK 2 automated system (BioMérieux), as well as the determination of their susceptibility to antifungal agents. Data were analyzed using the chi-square test. STATA 13.1 was used for statistical analysis (α = 5%). Of 44 patients with CAC, 33 (75%) had lesions classified as Newton type II. Yeasts were isolated in 38 cases. The most prevalent species was Candida albicans. None of the isolates were resistant to the antifungals tested. Our findings suggest that current indications for antifungal agents are appropriate. Also, antifungal susceptibility testing and proper fungal identification can help dentists to determine the optimal course of treatment for CAC.
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Mohammad, Abdel R., Peter J. Giannini, Philip M. Preshaw, and Howard Alliger. "Clinical and microbiological efficacy of chlorine dioxide in the management of chronic atrophic candidiasis: an open study." International Dental Journal 54, no. 3 (June 2004): 154–58. http://dx.doi.org/10.1111/j.1875-595x.2004.tb00272.x.
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Eisen, Drore. "The Therapy of Oral Lichen Planus." Critical Reviews in Oral Biology & Medicine 4, no. 2 (January 1993): 141–58. http://dx.doi.org/10.1177/10454411930040020101.
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Oral lichen planus is a chronic mucocutaneous disease that is relatively common. Although many patients are asymptomatic and require no therapy, those who exhibit atrophic and erosive lesions are often a challenge to treat. All therapies are palliative, and none is effective universally. Currently employed treatment modalities include corticosteroids administered topically, intralesionally, or systemically. Alternative therapies include topical and systemic retinoids, griseofulvin, Cyclosporine, and surgery. Other medical treatments and experimental modalities, including mouth PUVA, have been reported to be effective. Controversy concerning the efficacy of all these treatments suggests that oral lichen planus is a heterogeneous disorder. Eliminating lichenoid drug eruptions, candidiasis, trauma, contact mucositis, and emotional stress may play a role in the management of these patients. This article is a review of the many treatments and measures that have been employed in the management of patients with oral lichen planus.
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Andrucioli, Marcela Cristina Damião, Leandro Dorigan de Macedo, Heitor Panzeri, Elza Helena Guimarães Lara, and Helena de Freitas Oliveira Paranhos. "Comparison of two cleansing pastes for the removal of biofilm from dentures and palatal lesions in patients with atrophic chronic candidiasis." Brazilian Dental Journal 15, no. 3 (December 2004): 220–24. http://dx.doi.org/10.1590/s0103-64402004000300011.
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The efficacy of 2 oral hygiene products, an experimental toothpaste specific for complete denture cleansing and a regular standard toothpaste, was compared in terms of denture biofilm removal and cure of palatal lesions in patients with atrophic chronic candidiasis. The degree of correlation between presence of biofilm and mucosa erythema was also evaluated. Twenty-four complete denture wearers (45-80 years old) were divided into 2 groups: experimental paste and standard toothpaste (Sorriso-Kolynos, Brazil). Both groups received soft toothbrushes. The internal surfaces of upper dentures were stained using 1% sodium fluorescein and photographed at a 45º angle at 0, 15, 30 and 60 days. The slides were scanned and the areas of interest (denture total area and biofilm area) were measured (Image Tool software). The degree of erythema was evaluated on slides according to the Prosthesis Tissue Index. There was a significant reduction (1%) in the degree of biofilm (ANOVA/Tukey) between the two initial visits (0 and 15 days) and the two final visits (30 and 60 days), and in the average erythema scores (Kruskal-Wallis) between 0 and 60 days, in both groups. The Mann-Whitney test showed a significant difference (1%) between pastes in terms of biofilm degree, but no difference was found for the erythema score. Correlation values between biofilm and erythema degree were 0.3801 (experimental paste) and (0.3678 (standard toothpaste). We may therefore conclude that the experimental product was efficient for the removal of denture plaque biofilm.
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Hasbullah, Salsabila, Roedy Budirahardjo, and Niken Probosari. "Profil lesi jaringan lunak rongga mulut anak stunting kategori pendek dan sangat pendekProfile of oral soft tissue lesions in stunted and severely stunted children." Jurnal Kedokteran Gigi Universitas Padjadjaran 33, no. 2 (August 31, 2021): 159. http://dx.doi.org/10.24198/jkg.v33i2.33134.
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Pendahuluan: Stunting adalah keadaan kekurangan gizi kronis yang dipresentasikan secara antropometri berdasarkan nilai Z-score tinggi badan kurang dari -2 standar deviasi (SD) WHO Child Growth Standards pada kelompok umur dan jenis kelamin yang sama. Salah satu faktor utama penyebab stunting adalah defisiensi mikronutrien kronis pada 1000 hari pertama kehidupan secara spesifik pada vitamin B2, vitamin B6, zinc, dan zat besi Di sisi lain, defisiensi tersebut pun dapat menyebabkan berbagai lesi pada rongga mulut. Anak stunting memiliki risiko lebih tinggi pada lesi, penyakit bahkan kematian terutama pada anak stunting kategori sangat pendek. Tujuan penelitian untuk mengetahui profil lesi jaringan lunak rongga mulut pada anak stunting kategori pendek dan sangat pendek. Metode: Jenis penelitian observasional deskriptif dengan pendekatan cross sectional. Teknik pengambilan sampel dengan purposive sampling. Penelitian ini menggunakan data sekunder berupa data rekap bulanan status gizi berdasarkan Z-score oleh Puskesmas Jelbuk dan data primer berupa hasil pemeriksaan rongga mulut pada anak stunting. Hasil: Lesi jaringan lunak rongga mulut pada anak stunting kategori pendek adalah; Glositis (41,9%), Angular cheilitis (16,1%), Ulser (9,6%), Recurrent Apthous Stomatitis (6,4%), Oral Candidiasis (3,3%). Anak stunting kategori sangat pendek: Glositis (53,5%), Angular cheilitis (17,8%), Ulser (3,5%), Recurrent Apthous Stomatitis (7,1%), Oral Candidiasis (3,5%). Simpulan: Lesi jaringan lunak rongga mulut dengan prevalensi terbesar pada kedua kelompok kategori stunting adalah Athropic glossitis. Hal ini perlu mendapat perhatian khusus oleh praktisi kesehatan maupun pemerintah setempat karena kesehatan rongga mulut secara utuh akan memengaruhi asupan nutrisi bagi anak dan sebaliknya.Kata kunci: stunting; jaringan lunak rongga mulut; anak; lesiABSTRACTIntroduction: Stunting is a condition of chronic malnutrition presented anthropometrically based on the Z-score of height less than -2 standard deviations (SD) of the WHO Child Growth Standards in the same age and sex group. One of the main factors of stunting is chronic micronutrient deficiency in the first 1000 days of life, specifically of vitamin B2, vitamin B6, zinc, and iron. On the other hand, these deficiencies can also cause various lesions in the oral cavity. Stunting children have a higher lesion risk, disease, and even death, especially in severely stunted children. This study was aimed to examine the profile of oral soft tissue lesions in stunted and severely stunted children. Methods: The type of research used was descriptive observational research with a cross-sectional approach. The sampling technique used was purposive sampling. This study uses secondary data in the form of monthly recap data on the nutritional status based on Z-score by Jelbuk Health Center and primary data in oral cavity examination results in stunted children. Results: Oral soft tissue lesions in stunted children were glossitis (41.9%), angular cheilitis (16.1%), ulcer (9.6%), recurrent aphthous stomatitis (6.4%), and oral candidiasis (3.3%). Severely stunted children: Glossitis (53.5%), angular cheilitis (17.8%), ulcer (3.5%), recurrent aphthous stomatitis (7.1%), oral candidiasis (3.5%). Conclusions: The oral soft tissue lesion with the highest prevalence in both groups of stunting children was atrophic glossitis. This condition needs special attention from health practitioners and local governments because oral health will affect nutritional intake for children and vice versa.Keywords: stunting, oral soft tissue; children; lesion
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SEREFKO, ANNA D., EWA J. POLESZAK, and ANNA MALM. "Candida albicans Denture Biofilm and its Clinical Significance." Polish Journal of Microbiology 61, no. 3 (2012): 161–67. http://dx.doi.org/10.33073/pjm-2012-021.
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Fungi belonging to Candida genus, especially C. albicans play an important role in microflora of oral cavity. Microbial colonisation process taking place within oral cavity is inseparably related to formation of multispecies biofilm, i.e. dental and denture plaque. A mature fungal biofilm is a heterogeneous three-dimensional dense conglomeration of mixture of different morphological forms: blastospores, germ tubes, pseudohyphae and hyphae surrounded by the extracellular polymeric matrix. Composition and specific properties of substratum, saliva and yeasts as well as multiple intricate interactions between all of them influence the ability of Candida spp. isolates to adhere and colonise both natural and artificial surfaces, followed by biofilm formation. Obviously, specific complex host-pathogen interactions also should not be neglected. A lot of additional factors like poor oral and denture hygiene, low pH under prosthesis, sufficient concentration of sugar and iron or antibody titres influence Candida adhesion and colonisation of acrylic resin base. C. albicans is capable of inducing a variety of superficial diseases of the oral mucosa. The most common clinical form of oral candidal infection related to biofilm formation affecting a great deal of denture wearers is denture-associated stomatitis, also known as chronic atrophic candidiasis or erythemateous candidasis. Development of C. albicans biofilm on a denture surface constitutes a difficult and hard to resolve problem which may concern every single prosthesis-wearer. Thus, careful oral and denture hygiene is highly recommended for the population of artificial teeth wearers.
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Sumintarti, Sumintarti, and Andi Rasdiana S. "Manifestasi klinis tipe kandidiasis oral pada penderita AIDS di Rumah Sakit Dr Wahidin Sudirohusodo, Makassar (Clinical manifestations of oral candidiasis types in AIDS patients at Dr Wahidin Sudirohusodo Hospital, Makassar)." Journal of Dentomaxillofacial Science 13, no. 3 (October 30, 2014): 186. http://dx.doi.org/10.15562/jdmfs.v13i3.413.
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Oral candidiasis is one of clinical manifestations in aquired immune deficiency syndrome (AIDS) patients. This conditionis a common opportunistic infection of the oral cavity caused by an overgrowth of Candida spesies. The clinical types oforal candidiasis are erythematous or atropic, pseudomembranous, hyperplastic or chronic, and angular cheilitis. AIDS isgroup of symptoms that resulting from infection of human immunodeficiency virus (HIV). This case is associated with thedecreasing of CD4 count. The aimof this study was to know the types of oral candidiasis on AIDS patients at Dr WahidinSudirohusodo Hospital. This observational studywith a cross-sectional design examined 30 patients with AIDS whosuffered fromoral candidiasis, to determine its type after the diagnosis had confirmed by culture test. Their CD4 cellcount taken fromtheir medical records. The result showed that Pseudomembranous candidiasis were found to be higher(76.7%), that was followed by angular cheilitis (23.3%), hyperplastic (16.7%), and erythematous (6.7%). They wereshowed showed CD4 T cell count <200 cells/mm3 (63.3%). From this study, it was concluded that pseudomembranous candidiasis is the most common type and showed that CD4 T cell count <200cells/mmfrom the AIDS patients.
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Nikiforova, E. M., N. V. Malyuzhinskaya, M. A. Chueva, V. V. Alferova, and E. N. Solov’ev. "Endoscopic and morphological features of chronic subatrophic gastroduodenitis in children." Kazan medical journal 96, no. 1 (February 15, 2015): 42–45. http://dx.doi.org/10.17750/kmj2015-042.
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Aim. To identify the pecularities of clinical, functional features and morphological characteristics in children with subatrophic gastroduodenitis after eradication treatment.Methods. Gastrointestinal tract condition was examined in 26 children with subatrophic gastroduodenitis. Esophagogastroduodenoscopy with morphological analysis of biopsy specimens, esophageal pH test and urea breath test were performed.Results. 16 (60.7%) children reported low-grade pain, severe pain occurred in 3 (11.5%) patients, no abdominal pain was reported in 7 (27.6%) patients. A biopsy specimen was gained in 22 patients; moderate contamination with H. pylori was detected in 13 (59%) patients, severe - in 9 (41%) patients. Breath test was positive in all patients (n=26). Morphological study revealed fibrotic changes in 14 (63.6%) patients, atrophy and sclerosis lesions - in 7 (31.8%) and 17 (77.3%) patients, respectively, in addition to clear signs of inflammation. Intestinal metaplasia of the gastric mucosa was discovered in 4 (18.2%) children. Candidiasis of the stomach and duodenum was diagnosed in 7 (31.8%) children. All patients were administered standard eradication treatment. Repeated breath test after 4 weeks was positive in 9 (41%) patients, including 7 (31.8%) who were diagnosed with candidiasis by biopsy test. At 12 months, the control endoscopy performed in 19 patients: 5 patients, who failed to follow the recommendation, had marked clinical and endoscopic signs of relapse, no patients with good treatment compliance (n=14, 73.6%) had any clinical manifestations, although endoscopic signs of inflammation preserved in 9 (47.4%) children. Biopsy with histological examination was repeated in 9 patients. Signs of inflammation were significantly reduced in 6 (66.7%) patients, while the foci of atrophy, sclerosis and intestinal metaplasia retained in 2 out of 9 children. Contamination with H. pylori had significantly decreased.Conclusion. Endoscopic signs of gastroduodenal chronic inflammation correspond to the severity of morphological characteristics in the acute stage of gastroduodenitis. Children with preserved signs of intestinal metaplasia of gastric and duodenal mucosa require intensive treatment and prolonged follow-up.
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Skrypnіkova, T. P., and P. M. Skrypnikov. "DIAGNOSTIC AND TREATMENT CHARACTERISTICS OF LEPTOTHRICHOSIS OF THE ORAL MUCOSA." Ukrainian Dental Almanac, no. 3 (September 6, 2019): 16–20. http://dx.doi.org/10.31718/2409-0255.3.2019.03.
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Leptotrichia species play an important role in the microflora composition of the oral cavity, a genus of asporogenous gram-negative anaerobic bacteria, in the form of sticks that belong to the family of Fusobakterium. According to the morphological data, the structure of the cell wall, antigenic structure, they are part of the opportunistic flora of the oral cavity. Their peculiarities are the sensitivity to the toxic effects of oxygen, the absence of spores, the complexity of food processes. It also allows to refer them to the family of lactic acid bacteria that promote lactic acid fermentation.
Violation of homeostasis in the oral cavity and the presence of somatic diseases lead to the transformation of leptotrichia from the category of opportunistic microflora into pathogenic one. Different opinions about approaches to treatment in the presence of leptotrichia in the oral cavity are expressed. Some authors say that abundantly vegetative leptotrichia do not indicate pathology. Others, on the contrary, have the opposite view, believing that leptotrichosis is a disease close to opportunistic mycosis. But there is the third opinion: some authors attribute leptotrichosis to HIV - associated diseases. Clinical similarities with other fungal infections make it difficult to manage these patients.
There are some important traits for differential diagnosis such as identified symptoms, in some cases the lack of effectiveness of previous or current treatment, postponed and concomitant diseases, sociodemographic status, use of medicines. Subjective, objective and additional examination methods were used for diagnosis.
Objective examination of patients was carried out according to the recommendations of experts of the World Health Organization (WHO).
As additional method of examination it has been used microscopic research, which was the most effective, clinical analysis of blood, urine, blood for sugar. If necessary, patients were referred for consultation to other specialists. Candidiasis of the oral mucosa has a code ICD - B.370.
Patients have such complaints as burning of the mucous membrane of the lips, cheeks, hard and soft palate, dry mouth. There is a coarse keratinized epithelium of filamentous papillae, which gives them the appearance of spiky, pointed, very dense growths of gray or yellowish-gray color. The plaque may cover some areas of the oral mucosa. It adheres tightly to the tissues, is difficult to remove, exposing a loose bleeding surface. Inflammation is not identified. The mucous membrane appearance is worried patients, they examine it several times a day, which causes a phobia.
In some cases, the filamentous papillae of the tongue may be atrophied, it becomes smooth, but the color of the mucosa is not changed. Patients suffer from eating spicy food.
Among all diagnostic methods (subjective and objective) only the microscopic one is effective. Leptotrichosis accounts for 5 cases (4.09%) of the examined 122 patients with fungal origin stomatitis. This disease is quite rare, only a few clinical cases are described in the literature.
The pathogenesis of the disease (incomplete cellular immunity, shift of the phagocytic activity of neutrophils, monocytes, eosinophils, the host sensitization of leptotrichia’s byproducts, high saccharolytic activity, and others) is considered in leptotrichosis management. Leptotrichosis of the oral cavity mucosa is characterized by a chronic course (for several months). The treatment plan is made with an internist. A dentist has to know different alternative kind of treatment. Patients should be examined dynamically.
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Hidayat, Wahyu, Tenny Setiani Dewi, and Rudi Wisaksana. "Oral manifestations of anemia in HIV/AIDS patients without ARV treatment." Padjadjaran Journal of Dentistry 29, no. 1 (March 31, 2017). http://dx.doi.org/10.24198/pjd.vol29no1.11752.
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AbstractIntroduction: Acquired immunodeficiency syndrome (AIDS) is a set of symptoms caused by decreases of the immune system that was infected by human immunodeficiency virus (HIV). Blood disorders often found in patient with HIV and associated with HIV infection. Mostly found disorders is anemia of chronic disease. The prevalence of anemia in HIV/AIDS patients reaches 70%. Oral manifestations of anemia are atrophy of the papillae on tongue, glossodynia, pallor, angular cheilitis, glossitis, aphthous ulcers/erosive lesions, candidiasis, and geographic tongue. There are many publications that uses anemia as indicator to determine the prognosis of HIV infection, thus the description of oral manifestation of anemia in the non-ARV HIV/AIDS patients is a necessity. The purpose of this study was to describe the oral manifestation of anemia in the non-ARV HIV/AIDS patients. Methods: The methods used were purposive random sampling. Samples were new HIV/AIDS patients who have not got antiretroviral (ARV) treatment. The study included 40 patients in Teratai Clinic Hasan Sadikin Hospital Bandung. Results: Oral manifestations of anemia were found amongst non-ARV HIV/AIDS patients, which were candidiasis in 37 patients, glossodynia in 28 patients, glossitis in 10 patients, and angular cheilitis in 1 patient. Conclusion: From the study found that oral manifestations of anemia that found in non-ARV HIV/AIDS patients were candidiasis, glossodynia, glossitis and angular cheilitis. HIV/AIDS patients with anemia needed to treat more intensive for better prognosis and quality of life.Keywords: Anemia, HIV/AIDS, Candidiasis, Glossitis, Glossodynia
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Shikdar, Yasamen Abdulmannan, Abdullah Almazrooa, and Shaza Samargandy. "SAT-071 Autoimmune Polyglandular Syndrome Type 1 with Common Variable Immunodeficiency." Journal of the Endocrine Society 4, Supplement_1 (April 2020). http://dx.doi.org/10.1210/jendso/bvaa046.152.
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Abstract BACKGROUND: Autoimmune polyglandular syndrome (APS) is a rare disorder. It’s co-existence with common variable immunodeficiency (CVID) was reported in 5 cases before but, none of them was APS type 1up to our knowledge. The overlap between the 2 conditions indicates a possible association between Autoimmunity and immunodeficiency. CLINICAL CASE: A 21-year-old lady was diagnosed to have CVID since infancy, as she was presenting to the hospital with recurrent infections and sepsis. At the age of 7 months, she was diagnosed with type 1 diabetes and was started on insulin. Furthermore, at 2 years of age she was found to have primary hypothyroidism and in her teenage she was diagnosed with primary adrenal insufficiency. Her history became more complicated when she also started to develop recurrent oral and esophageal candidiasis that required systemic anti-fungal therapy. Later in her life, she was incidentally found to have hypoparathyroidism when her labs showed hypocalcemia with inappropriately normal parathyroid hormone. She had chronic diarrhea which was thought to be due to celiac disease based on intestinal biopsy showing villous atrophy. With her IgA deficiency, her Tissue transglutaminase IgA antibodies were not reliable. Splenic atrophy was also detected on abdominal imaging. She never reached puberty and elected with her parents to not start combined hormonal therapy. With the constellation of these features, we concluded that she has type 1 APS along with CVID. CONCLUSION: Autoimmunity and immunodeficiency might be interconnected. Early diagnosis will affect the quality of life and early targeted treatment will prevent morbidity and early mortality. KEY WORDS: Autoimmune Polyglandular Syndrome, Common Variable Immunodeficiency.