Academic literature on the topic 'Chronic bone pain with nocturnal exacerbation'

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Journal articles on the topic "Chronic bone pain with nocturnal exacerbation"

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Barakat, Mohammed M. A., Kadir Ertem, and Hüseyin Utku Özdeş. "An Uncommon Mass in The Distal Ulna; A Case of Atypical Osteoid Osteoma." European Journal of Therapeutics 31, no. 1 (2025): 67–70. https://doi.org/10.58600/eurjther2595.

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Osteoid osteoma (OO) is a benign osteoblastic tumor that commonly occurs in the diaphysis of long bones but is rarely found in peri-articular locations, particularly the wrist. This case report describes a 19-year-old female who presented with chronic wrist pain lasting two years, accompanied by nocturnal exacerbation and tenderness over the distal ulna. Imaging revealed a radiolucent lesion with a nidus, leading to a diagnosis of OO, later confirmed histologically following surgical excision. Differential diagnoses such as ulnar impingement syndrome, triangular fibrocartilage complex (TFCC) i
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Lee, Jong Wook, Jun Ho Jang, Je-Hwan Lee, et al. "Ineffective Corticosteroid Treatment for Hemolysis Management of Paroxysmal Nocturnal Hemoglobinuria." Blood 124, no. 21 (2014): 5151. http://dx.doi.org/10.1182/blood.v124.21.5151.5151.

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Abstract Background: The primary clinical manifestations of paroxysmal nocturnal hemoglobinuria (PNH) are hemolytic anemia, bone marrow failure (BMF), and thromboembolism (TE). For optimum management, the contribution of both hemolysis and BMF to the complex anemia of PNH should be determined. The treatment of a hemolytic episode should aim at diminishing hemolysis and preventing complications. Corticosteroids as treatment, for both chronic hemolysis and acute hemolytic exacerbations have been used with a variety of side effects of long term use. In the Korean PNH population, corticosteroid (7
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Kwon, Byung Jin, Hyung Wook Kim, Su Bum Park, et al. "Paroxysmal Nocturnal Hemoglobinuria Presenting with Chronic Abdominal Pain and Iron Deficiency Anemia." Korean Journal of Medicine 95, no. 1 (2020): 56–60. http://dx.doi.org/10.3904/kjm.2020.95.1.56.

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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder of hematopoietic stem cells characterized by chronic intravascular hemolysis, nocturnal hemoglobinuria, thromboembolic events and secondary bone marrow failure caused by uncontrolled complement activation. Generally, chronic abdominal pain and iron deficiency anemia are considered typical symptoms of gastrointestinal diseases, but are also common in PNH. We report a case of PNH presenting with chronic abdominal pain and iron deficiency anemia, along with a relevant literature review.
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Arnold, Louise M., Jill Stephenson, Richard Kelly, David Buchanan, Gareth Jones, and Peter Hillmen. "Home Infusion of Eculizumab: A Unique and Innovative Model of Drug Delivery to Reduce Treatment-Associated Burden and Enhance Quality of Life for Patients with PNH." Blood 112, no. 11 (2008): 4671. http://dx.doi.org/10.1182/blood.v112.11.4671.4671.

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Abstract Paroxysmal Nocturnal Hemoglobinuria (PNH) is an acquired clonal stem cell disease, characterised by intravascular hemolysis, bone marrow failure and lifethreatening thromboses. The median survival is 10–15 years, with the average age of presentation being in the 30’s. Symptoms include hemoglobinuria, fatigue, anemia, venous and arterial thromboses, recurrent pain, renal impairment, erectile dysfunction and pulmonary hypertension. The care of a patient with PNH is complex and challenging, as many experience chronic symptoms with periods of acute exacerbations. Historically the manageme
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Hussein, Naglaa. "Autoimmune hepatitis complicated with entrapment neuropathy & fibromyalgia: A case report." International Physical Medicine & Rehabilitation Journal 7, no. 2 (2022): 76–77. http://dx.doi.org/10.15406/ipmrj.2022.07.00308.

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46. y-old right-handed female with history of controlled autoimmune hepatitis since 2001 with negative liver biopsy on 2017 presented with chronic generalized pain affecting neck, upper back, buttocks, knee and chest associated with paresthesia and tingling of left hand with nocturnal exacerbation. Clinical exam revealed; Neurologically Positive Tinel sign over median nerve at wrist bilaterally, Positive Phalen test bilaterally, Musculoskeletal exam revealed multiple tender points bilaterally with limited neck Rom due to pain. Electrophysiological testing of both upper extremities documented b
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Amendola, A., G. Paternoster, S. P. Pascale, et al. "Coronary Artery By-Pass Grafting in Patient With Paroxysmal Nocturnal Hemoglobinuria (Case Report)." General Reanimatology 17, no. 2 (2021): 27–36. http://dx.doi.org/10.15360/1813-9779-2021-2-27-36.

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Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic stem cell disease that presents with haemolytic anaemia, thrombosis and bone marrow failure. We report a case of a 51-year-old male with a history of PNH in treatment with Eculizumab admitted to our Hospital for acute chest pain and dyspnoea. The diagnosis was a triple vessel disease and patient was scheduled for coronary artery bypass grafting surgery. To balance the risk between thrombosis and bleeding in this particular clinical setting, we decided to use thromboelastography (TEG) as point of care solution and we used the
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Brodsky, Andres L., Brenner Sabando Velez, and Curutchet Ragusin. "Eculizumab Treatment of Paroxysmal Nocturnal Hemoglobinuria Relapsing After Bone Marrow Transplant and Subsequent Clonal: Case Report." Blood 118, no. 21 (2011): 5274. http://dx.doi.org/10.1182/blood.v118.21.5274.5274.

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Abstract Abstract 5274 Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a chronic and life-threatening hematopoietic stem cell disorder characterized by deficiency of the GPI-anchored complement inhibitory proteins CD55 and CD59 on blood cells. The resulting uncontrolled complement activation is responsible for chronic hemolysis and can lead to serious clinical morbidities including thromboembolism (TE) and chronic kidney disease (CKD), which have been shown to increase risk of mortality. Patients may also experience debilitating quality-of-life (QoL) issues, including fatigue, shortne
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Easwar, V. Ra Rathina, R. Navaneethakrishnan, and Yogeshwar Agharkar. "A Case Report of Acute on Chronic Osteomyelitis of Distal Femur Managed with Sequestrectomy, Saucerization, and Stimulan Placement." Journal of Orthopaedic Case Reports 15, no. 7 (2025): 163–67. https://doi.org/10.13107/jocr.2025.v15.i07.5808.

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Introduction: Osteomyelitis is a bone infection that may present acutely or chronically. Acute on chronic osteomyelitis refers to the exacerbation of symptoms in a patient with an underlying chronic infection. This case report presents a 19-year-old male diagnosed with acute on chronic osteomyelitis of the right distal femur, with no history of a discharging sinus for the past 6 months. Osteomyelitis is a bone infection commonly caused by bacteria, with Staphylococcus aureus being the most frequent pathogen. Chronic osteomyelitis can occasionally experience acute flare-ups, referred to as “acu
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Takimot, Kayo. "Serratus Plane Block for Persistent Pain after Partial Mastectomy and Axillary Node Dissection." March 2016 3;19, no. 3;3 (2016): E481—E486. http://dx.doi.org/10.36076/ppj/2019.19.e481.

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Persistent pain after breast cancer surgery (PPBCS) is defined as chronic neuropathic pain that persists for more than 3 months after surgery. The pain can be sufficiently severe to cause long-term disabilities and interfere with sleep and daily life. Serratus plane block (SPB) is a novel, ultrasound-guided regional anesthetic technique that is suggested to achieve complete anesthesia of the anterolateral chest wall. Here, we demonstrate the efficacy of SPB as one of the treatment modalities for patients with PPBCS. A 73-year-old woman underwent a left partial mastectomy and axillary node diss
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Salar, O., B. Baker, T. Kurien, A. Taylor, and C. Moran. "Septic arthritis in the era of immunosuppressive treatments." Annals of The Royal College of Surgeons of England 96, no. 2 (2014): e11-e12. http://dx.doi.org/10.1308/003588414x13814021678196.

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Immunosuppressants have been the mainstay of treatment for certain inflammatory joint conditions for many years. Developments in this field, namely biological treatments, have led to a change in the classical presentation of acute bone, joint and soft tissue infections. The normal findings of severe pain and tenderness on examination may be absent or simply mimic a typical exacerbation of the chronic joint condition. A minimally raised white cell count and elevated C-reactive protein in the absence of systemic signs of infection may be interpreted as further evidence for the diagnosis of an ex
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Books on the topic "Chronic bone pain with nocturnal exacerbation"

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Voinescu, Alexandra, Nadia Wasi Iqbal, and Kevin J. Martin. Management of chronic kidney disease-mineral and bone disorder. Edited by David J. Goldsmith. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0118_update_001.

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In all patients with chronic kidney disease (CKD) stages 3–5, regular monitoring of serum markers of CKD-mineral and bone disorder, including calcium (Ca), phosphorus (P), parathyroid hormone (PTH), 25-hydroxyvitamin D, and alkaline phosphatase, is recommended. Target ranges for these markers are endorsed by guidelines. The principles of therapy for secondary hyperparathyroidism include control of hyperphosphataemia, correction of hypocalcaemia, use of vitamin D sterols, use of calcimimetics, and parathyroidectomy. of hyperphosphataemia is crucial and may be achieved by means of dietary P rest
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