Relevant bibliographies by topics / Chronic degenerative disease

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Chronic degenerative disease'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 February 2022

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Journal articles on the topic "Chronic degenerative disease"

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&NA;. "Chronic Pain a Degenerative Disease?" Lippincott's Bone and Joint Newsletter 16, no. 2 (February 2010): 21–22. http://dx.doi.org/10.1097/01.bonej.0000367962.07481.7b.

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&NA;. "Chronic Pain a Degenerative Disease?" Back Letter 24, no. 12 (December 2009): 137. http://dx.doi.org/10.1097/00130561-200912000-00006.

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Di Renzo, Laura, Paola Gualtieri, and Antonino De Lorenzo. "Diet, Nutrition and Chronic Degenerative Diseases." Nutrients 13, no. 4 (April 20, 2021): 1372. http://dx.doi.org/10.3390/nu13041372.

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Chronic degenerative diseases (CDDs), represented mainly by obesity, cardiovascular disease (CVD), diabetes, chronic kidney disease (CKD), inflammatory bowel diseases, osteoporosis, sarcopenia, neurodegenerative diseases such as Huntington’s disease (HD), rheumatoid arthritis (RA), chronic respiratory diseases, and many cancers, have been, up to now, the most frequent causes of prolonged disability and death worldwide [...]
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Madeira, Maria H., Raquel Boia, Paulo F. Santos, António F. Ambrósio, and Ana R. Santiago. "Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases." Mediators of Inflammation 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/673090.

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Retinal degenerative diseases are major causes of vision loss and blindness worldwide and are characterized by chronic and progressive neuronal loss. One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. There is growing evidence that retinal microglia, as in the brain, become activated in the course of retinal degenerative diseases, having a pivotal role in the initiation and propagation of the neurodegenerative process. A better understanding of the events elicited and mediated by retinal microglia will contribute to the clarification of disease etiology and might open new avenues for potential therapeutic interventions. This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.
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Di Nicola, V. "Degenerative osteoarthritis a reversible chronic disease." Regenerative Therapy 15 (December 2020): 149–60. http://dx.doi.org/10.1016/j.reth.2020.07.007.

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Andari, Fatmi, and Tria Damayanti. "Role of Mesenchymal Stem Cells In Chronic Obstructive Lung Disease." Respiratory Science 1, no. 3 (June 23, 2021): 202–12. http://dx.doi.org/10.36497/respirsci.v1i3.26.

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Therapy for Chronic Obstructive Pulmonary Disease (COPD) is currently still not giving effect to tissue repair and regeneration. Chronic Obstructive Pulmonary Disease is still a progressive degenerative disease. Stem cells through their regenerative ability offer a new promising alternative therapy for the management of degenerative diseases including COPD. There have been many studies conducted to determine the safety and efficacy of stem cells in COPD. Published research about stem cells on COPD is still in phase II. Further research is needed on a larger scale before stem cells can be widely applied in the management of COPD. Stem cells are a very promising alternative therapy and are a big leap in the medical world for degenerative diseases including COPD.
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Kim, Jun, Hong Lan Jin, Dae Sik Jang, Kwang Won Jeong, and Se-Young Choung. "Quercetin-3-O-α-l-arabinopyranoside protects against retinal cell death via blue light-induced damage in human RPE cells and Balb-c mice." Food & Function 9, no. 4 (2018): 2171–83. http://dx.doi.org/10.1039/c7fo01958k.

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Olszewer, Efrain, and James P. Carter. "EDTA chelation therapy in chronic degenerative disease." Medical Hypotheses 27, no. 1 (September 1988): 41–49. http://dx.doi.org/10.1016/0306-9877(88)90082-5.

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Tai TC Huang, HP. "Echocardiographic assessment of right heart indices in dogs with elevated pulmonary artery pressure associated with chronic respiratory disorders, heartworm disease, and chronic degenerative mitral valvular disease." Veterinární Medicína 58, No. 12 (December 20, 2013): 613–20. http://dx.doi.org/10.17221/7180-vetmed.

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The aim of this study was to evaluate right ventricular (RV) remodeling and right heart failure associated with different causes of elevated pulmonary arterial pressure (PAP) in dogs. In total, 169 client-owned dogs with tricuspid regurgitation (TR) and 40 client-owned clinically healthy dogs were included. Dogs with TR were further categorised as suffering from chronic respiratory disorders (CRD), heartworm disease (HWD), mild/moderate chronic degenerative mitral valvular disease (CDMD), and severe CDMD. Among the echocardiographic indices of the right heart, no significant difference in the tricuspid annular plane systolic excursion to aortic root diameter ratio was found among the clinical healthy controls and the four different TR categories. No significant differences in TR peak velocity and pulmonic regurgitation peak velocity were found among dogs in the four different TR categories. The ratio of the right to left ventricular basal diameter in the right ventricular-focused view was significantly higher in dogs with chronic respiratory disorders and dogs with heartworms. Left ventricular compression quantified using the eccentricity index and the ratio of the main pulmonary artery to aortic root diameter were significantly higher in dogs with HWD. Their right ventricular acceleration to ejection time (AT/ET) was significantly lower in dogs with HWD. Based on these findings, we conclude that right heart indices are affected by CRD, HWD, and moderate to severe CDMD. However, right heart indices derived from left heart measurements might be underestimated in dogs with CDMD.
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Choi, Keum Hwa, Gail Buhl, and Julia Ponder. "Raptor Acupuncture for Treating Chronic Degenerative Joint Disease." Journal of Acupuncture and Meridian Studies 9, no. 6 (December 2016): 330–34. http://dx.doi.org/10.1016/j.jams.2016.09.020.

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Dissertations / Theses on the topic "Chronic degenerative disease"

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Vloumidi, Eleni I. "Investigations into the development of chronic degenerative valve disease in dogs." Thesis, University of Nottingham, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.576156.

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In dogs chronic degenerative valve disease (CDVD) is the most common cardiac disorder and the most frequent cause of cardiac failure seen in clinical practice. The aetiology of CDVD is unknown however recent investigations have focused on the molecular mechanisms that may be implicated in the development of the disease. This thesis investigates the impact of mechanical stimuli on the canine mitral valve at both the molecular and clinical level. At the molecular level canine valvular interstitial cells (VICs) were successfully extracted from valve tissue and shown to express proteins related to both the contractile and synthetic properties of the valve; therefore they were characterized as myofibroblasts. Furthermore, no change in phenotype after freezing and thawing was evident suggesting that freezing had no effect on the integrity and the contractile, synthetic and metabolic properties of the cells. This was demonstrated by maintenance of the expression of alpha-smooth muscle actin (ASMA), prolyl-4-hydroxylase (4-HP) and creatine kinase B (CK-B) respectively. Mitral VICs (MVICs) had greater contractile and synthetic properties than tricuspid VICs (TVICs), evidenced by a higher expression of ASMA and 4-HP. This difference was likely to be a consequence of exposure to higher pressures throughout the cardiac cycle. It was also demonstrated that canine MVICs from both normal and diseased valves respond to mechanical stretch by hypertrophy, increasing the production of protein per unit cell. Furthermore, MVICs of both normal and diseased valves lose their contractile phenotype in response to mechanical stretch, indicated by a fall in ASMA expression. It was also demonstrated that the MVICs of diseased German shepherd dogs were more resistant to stretch than the MVICs of normal and diseased beagles. At the clinical level no gross lesions were observed echocardiographically on the mitral valves of the greyhounds irrespective of the dogs' age and training status. This suggests that the mitral valves of the greyhounds are more resistant to mechanical stimuli. However, these dogs develop mitral regurgitation with advancing age possibly due to alterations in heart geometry.
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Martins, Brigite de Lima Novo Dantas. "Lesão degenerativa crónica da valva mitral em canídeos: epidemiologia e diagnóstico ecocardiográfico : estudo retrospectivo de 41 casos." Bachelor's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2008. http://hdl.handle.net/10400.5/948.

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Dissertação de Mestrado Integrado em Medicina Veterinária
Esta dissertação é resultado do estágio realizado no Instituto Veterinário do Parque e integra uma exposição breve da casuística acompanhada, uma revisão bibliográfica sobre a Lesão Degenerativa Crónica da Valva Mitral (LDCVM) e o diagnóstico ecocardiográfico desta doença e, finalmente, um estudo clínico dentro deste tema. A LDCVM é a doença cardíaca adquirida mais frequente em canídeos adultos, atingindo principalmente animais a partir dos 8 anos de idade e de raças de pequeno a médio porte, sendo raríssima a sua descrição em cães de raças grandes. Esta é uma doença progressiva e sem cura, pelo que é importante que o médico veterinário possa detectar a sua presença o mais cedo possível, a fim de estabelecer um plano terapêutico que permita retardar a progressão da LDCVM e suavizar a sintomatologia clínica do paciente. A ecocardiografia é considerada o meio complementar de diagnóstico mais útil na avaliação desta afecção cardíaca, caracterização do estadio da doença e classificação do grau de insuficiência cardíaca dos pacientes. No diagnóstico ecocardiográfico da LDCVM existem vários parâmetros que podem ser avaliados, alguns dos quais quantificáveis, que fornecem informações de grande relevância para o médico-veterinário. Os objectivos principais do estudo clínico realizado consistiram na realização de medições ecocardiográficas e na verificação da existência de relação entre estas e a severidade da insuficiência cardíaca. A amostra foi constituída por 41 canídeos presentes à consulta de Cardiologia tendo todos sido sujeitos a, pelo menos, um exame ecocardiográfico. Utilizou-se o modo 2D para a avaliação do espessamento dos folhetos valvulares da mitral, detecção de situações de prolapso da valva mitral e mensuração das dimensões do átrio esquerdo e base da aorta. O modo TM foi utilizado para determinar a fracção de encurtamento, frequência cardíaca e separação do septo ao ponto E. O modo Doppler Cor permitiu detectar situações de regurgitação mitral. A análise estatística foi realizada com base em métodos descritivos e inferenciais, tendo-se para isso utilizado o teste para variáveis não paramétricas de Kruskal- Wallis. Apesar de não se terem encontrado relações estatisticamente significativas entre a severidade da insuficiência cardíaca e a variação da fracção de encurtamento, da frequência cardíaca, da idade e peso corporal, os valores obtidos encontram-se dentro dos intervalos descritos na literatura. Por fim, verificou-se um aumento do rácio da dimensão do átrio esquerdo/dimensão base aorta a par do agravamento do estado clínico do animal, e concomitante aumento do grau de insuficiência cardíaca (p=0,001).
ABSTRACT - This dissertation was based on the work performed at the Instituto Veterinário do Parque and includes a brief presentation of the followed clinical cases, a bibliographic review about the Chronic Degenerative Mitral Valve Disease and it’s echocardiographic diagnose, as well as a retrospective study within this subject. Degenerative mitral valve disease is the most frequent disease of adult dogs, affecting mostly elderly animals from aproximately the age of eight years old. Small to medium breeds are the most affected and reports of this disease on large dog breeds are very rare. This is a progressive degenerative disease wich has no cure. For this reason is very important for the veterinary surgeon to detect it as early as possible and to establish a therapeutic plane aimed to the improvement of the pacient’s quality of life. Echocardiography is considered the most useful diagnostic test for the evaluation of degenerative mitral valve disease, providing important information about the valve morphology and lesions as well as allowing a noninvasive and accurate assessment of the heart failure stage. There are several relevant echocardiographic patterns and measures used to diagnose this disease. The main objective of the presented retrospective study was to perform some of the most reliable measurements and to verify the existence of statistical relations between this measures and the heart failure severity. Forty-one dogs presented for cardiology consultation were examined and all underwent to at least one echocardiographic examination. The 2D-mode was used to evaluate the thickness of the mitral valve leaflets, to recognise the mitral valve prolapse and to measure the left atrium and aortic root dimensions. The M-mode was performed to determine the shortening fraction, heart rate and mitral E-point septal separation. Mitral valve regurgitation was detected using color Doppler. The statistical methods performed included descriptive and inferencial analysis. Statistical differences among groups were studied using the non-parametric Kruskal-Wallis test. Although there were no statistical differences between the heart failure class and the variation of the shortening fraction, heart rate, age and body weight, the obtained mean values agree with the consulted literature. Finally it was found that the left atrium to aortic ratio was higher in the more severe heart failure classes, increasing with the progression of the presented clinical signs (p=0,001).
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Ueda, Mariana Yukari. "Amplitude de distribuição das hemácias (RDW) e Proteína-C Reativa (CRP) em cães com doença valvar degenerativa crônica mitral." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-09122015-105601/.

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O RDW é um índice hematológico utilizado para avaliação quantitativa da anisocitose eritrocitária, sendo útil na diferenciação das causas de quadros anêmicos. Atualmente, na medicina humana, o RDW tem sido considerado como um importante fator prognóstico em quadros de ICC, mesmo na ausência de anemia. A CRP é considerada a principal proteína de fase aguda sendo amplamente utilizada como marcadora de inflamação. O objetivo deste estudo foi determinar se há diferença nos valores do RDW e da concentração da CRP em cães com DVDCM com e sem ICC, bem como nos diferentes estágios (A, B1, B2, C e D) da doença, segundo a classificação da ACVIM, comparados a cães de raças predispostas, mas sem a doença cardíaca, e associações entre as variáveis. Esta pesquisa constituiu um estudo clínico observacional prospectivo transversal de caráter exploratório, realizada em cães com DVDCM. Para tal, foram selecionados 141 cães, de até 20kg, machos e fêmeas. O grupo com ICC e sem ICC apresentaram menor número de hemácias, hemoglobina e hematócrito em relação ao grupo controle (P<0,001). O índice RDW não diferiu entre os grupos estudados quando foram alocados quanto ao estadiamento ACVIM (P= 0,25), quanto à presença de ICC (P= 0,146), ou de remodelamento cardíaco (P=0,078). Quanto à CRP, os grupos C e D (C: 2.251 ng/dL, 962,05-5.292,5 ng/dL e D: 3.628,4 ng/dL, 4.1592,3-6.254,5 ng/dL) apresentaram concentração maior que o grupo controle (1.685,5 ng/dL, 1.045,45-3.795,5 ng/dL). Quanto ao estadiamento da DVDCM os grupos diferiram entre si (P=0,014) porém, não foi possível identificar quais grupos apresentaram diferença. O grupo com ICC (2.939,7-1.304,25-5.908,8 ng/dL) apresentou maior concentração de CRP em relação ao grupo controle (1.685 ng/dL, 1.1015,45-3.795,5 ng/dL) (P=0,03). O grupo com remodelamento (4.916,66±6.102,14) apresentou maior concentração de CRP em relação ao grupo sem remodelamento (2.510,67±3,26) (P=0,009). Houve correlação positiva fraca entre CRP e número total de leucócitos (r=0,197; P=0,019). Conclui-se que apesar de não ter sido detectada diferença significativa para o RDW houve tendência a valores maiores nos cães com remodelamento comparados aos sem remodelamento. A concentração de CRP foi maior nos cães com remodelamento cardíaco em relação àqueles sem remodelamento e nos cães com ICC em relação aos cães sem ICC e àqueles de raças predispostas, mas sem alterações cardíacas. A dosagem sérica de CRP juntamente com outros marcadores e exames complementares já utilizados rotineiramente, poderá ser útil na avaliação e acompanhamento de pacientes portadores de DVDCM
RDW is a hematological index used for anisocytosis quantitative assesment, and useful to diferenciate anemic states. In human medicine, it has been considered an important prognostic factor in heart failure (HF), even in the absence of anemia. CRP is considered the main acute phase protein, and it is widely used as a marker of inflammation. An exploratory prospective cross sectional study was conducted aiming to determine whether there is a difference in RDW and CRP concentration in dogs with chronic degenerative mitral valve disease (CDMVD) with and without HF, presence of remodeling, as well as between the different disease stages (A, B1, B2, C e D - ACVIM), compared to dogs of predisposed breeds, but without heart disease. For this study, 141 dogs, up to 20kg, males and females were distributed in groups in order to achieve the main golas. Dogs with and without HF presented smaller number of red blood cells, hemoglobin and hematocrit compared to control group (P<0.001). RDW was not diferente between groups for CDMVD stages (P= 0.25), regarding HF presence (P= 0.146), or cardiac remodeling (P=0.078). Groups C and D (C: 2,251 ng/dL, 962.05-5,292.5 ng/dL e D: 3,628.4 ng/dL, 4,1592.3-6,254.5 ng/dL) presented higher CRP concentration compared to control (1,685.5 ng/dL, 1,045.45-3,795.5 ng/dL). There was a difference in CRP concentration between groups, however, it was not possible to identify the differing groups (P=0.014). CRP concentration was higher in HF group (2,939.7-1,304.25-5,908.8 ng/dL) compared to control (1,685 ng/dL, 1,1015.45-3,795.5 ng/dL) (P=0.03). CRP concentration was higher in cardiac remodeling group (4,916.66±6,102.14) in relation to the group without remodeling (2,510.67±3.26) (P=0.009). There was a weak positive correlation between CRP and total leucocyte count (r=0.197; P=0.019). We conclude that although we could not identify a significative difference for RDW, there was a tendency to increased values in dogs with cardiac remodeling. CRP concentration was higher in cardiac remodeling group and in HF group compared to control. CRP serum together with other markers and auxiliary exames already routinely used may provide useful information for assessment and follow up of dogs with CDMVD
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Botte, José Martins de Carvalho Sacadura. "Correlações entre achados ecocardiográficos e parâmetros de qualidade de vida em cães com doença degenerativa crónica da válvula mitral." Master's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2012. http://hdl.handle.net/10400.5/4837.

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Dissertação de Mestrado Integrado em Medicina Veterinária
Contexto: A doença degenerativa crónica da válvula mitral (DDCVM) é a doença cardíaca adquirida mais frequente em canídeos adultos e, pelo seu carácter de progressão crónica, tem um impacto negativo marcado na qualidade de vida dos doentes. A ecocardiografia transtorácica é considerada o método de diagnóstico de eleição para esta doença, e algumas variáveis ecocardiográficas ajudam a identificar animais em risco acrescido de morte. Objectivos: Analisar a existência e significância de correlações entre achados ecocardiográficos e parâmetros de qualidade de vida em cães com DDCVM, de forma a determinar a utilidade desta ferramenta de diagnóstico por imagem como método de avaliação objectiva da qualidade de vida de cães com a referida doença. Animais: Dezoito cães de clientes particulares, 9 machos e 9 fêmeas, de diversas raças e idades, com DDCVM de vários graus de gravidade. Materiais e Métodos: Estudo prospectivo observacional. A qualidade de vida dos cães foi avaliada por um questionário online entregue aos donos; foi realizada ecocardiografia transtorácica 2B, modo-M e Doppler a todos os animais. Utilizou-se o teste de correlação de postos de Spearman para determinar as correlações entre as variáveis de interesse. Resultados: Foram encontradas múltiplas correlações entre as variáveis ecocardiográficas e os parâmetros de qualidade de vida em análise. A gravidade de regurgitação mitral destacou-se pelo número e significância das correlações encontradas. Os índices ecocardiográficos de função diastólica, sobrecarga de volume e remodelação de câmaras cardíacas também demonstraram correlações importantes com os parâmetros de qualidade de vida estudados, evidenciando a responsabilidade dos fenómenos congestivos associados à insuficiência cardíaca nos sinais clínicos manifestados pelos doentes. Conclusões e Importância Clínica: A constatação de que as variáveis ecocardiográficas às quais tem sido atribuído um maior valor prognóstico podem ser igualmente úteis na avaliação objectiva do impacto da DDCVM na qualidade de vida dos doentes, confere à ecocardiografia, para além do seu comprovado valor diagnóstico, uma importância crescente no acompanhamento da progressão da doença ao longo do tempo.
ABSTRACT - CORRELATIONS BETWEEN ECHOCARDIOGRAPHIC FINDINGS AND QUALITY OF LIFE PARAMETERS IN DOGS WITH CHRONIC DEGENERATIVE MITRAL VALVE DISEASE - Background: Chronic degenerative mitral valve disease (CDMVD) is the most common acquired cardiac disease in adult canines and, due to its chronic progressive character, has a marked negative impact on the quality of life of the patients. Transthoracic echocardiography is considered to be the gold standard diagnostic method for this disease, and some echocardiographic variables help to identify animals at higher risk of death. Objectives: To analyse the existence and significance of correlations between echocardiographic findings and quality of life parameters in dogs with CDMVD, in order to determine the utility of this diagnostic imaging tool as a method to objectively evaluate the quality of life in dogs with the aforementioned disease. Animals: Eighteen client owned dogs, 9 males and 9 females, of various breeds and ages, with CDMVD of varying severity. Materials and Methods: Prospective observational study. The quality of life of the dogs was assessed by an online questionnaire sent to the owners; transthoracic 2B, M-mode and Doppler echocardiography was performed on all animals. Spearman’s rank correlation test was used to determine the correlations between the variables of interest. Results: Multiple correlations were found between the echocardiographic variables and the quality of life parameters in analysis. The severity of mitral regurgitation stood out by the number and significance of correlations found. The echocardiographic indices of diastolic function, volume overload and cardiac chamber remodeling also showed important correlations with the studied quality of life parameters, highlighting the responsibility of the congestive phenomena associated with heart failure in the clinical signs manifested by the patients. Conclusions and Clinical Importance: The evidence that the same echocardiographic variables to which a prognostic value has been attributed may be equally useful in the objective evaluation of the impact of CDMVD on the quality of life of the patients, confers echocardiography, besides its proven diagnostic value, a growing importance in the follow up of the progression of the disease over time.
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Figueiredo, Andreia Raquel Marques de. "A dilatação atrial esquerda em canídeos : lesão degenerativa crónica da valva mitral como sua principal causa : estudo integrado do biomarcador NT-proBNP." Master's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2012. http://hdl.handle.net/10400.5/4843.

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Dissertação de Mestrado Integrado em Medicina Veterinária
A dilatação atrial esquerda (DAE) é uma alteração morfológica cardíaca que acompanha grande parte das insuficiências cardíacas, podendo ser consequência de sobrecarga de volume ou de pressão. São variadíssimas as doenças capazes de conduzir a DAE, destacando-se a lesão degenerativa crónica da valva mitral (LDCVM). Esta é a doença cardíaca adquirida mais comum nos canídeos adultos e afeta principalmente raças de pequeno e médio porte. A ecocardiografia é considerada o meio complementar de diagnóstico primordial de DAE, uma vez que é mais sensível do que a radiografia torácica e o eletrocardiograma (ECG), também estes úteis na sua deteção. O biomarcador cardíaco NT-proBNP tem-se afigurado também com utilidade na deteção de doença cardíaca, tendo já sido correlacionado com o grau de DAE. O prognóstico de DAE depende essencialmente da doença subjacente, sua duração e tratamento. As complicações de DAE incluem essencialmente disritmias, hipertensão pulmonar (HP), insuficiência cardíaca congestiva (ICC) e, raramente, rotura atrial esquerda (RAE). Esta dissertação visa assim abordar os aspetos referentes às doenças subjacentes, diagnóstico e complicações da DAE, e por fim relatar um estudo efetuado com casos de DAE. Os principais objetivos deste estudo passaram pela investigação das principais doenças associadas a DAE em canídeos e do peso da LDCVM na sua prevalência, assim como pela pesquisa da relação entre o grau de DAE, a duração da onda P do ECG e a concentração plasmática do NT-proBNP (este último apenas em casos de LDCVM). Foram ainda estudadas a epidemiologia e principais complicações da DAE. Os principais parâmetros ecocardiográficos e eletrocardiográficos foram recolhidos em 54 canídeos com DAE, e ainda medida a concentração plasmática do NT-proBNP em 30 canídeos com LDCVM (com e sem DAE). A LDCVM evidenciou-se-se como a principal doença associada a DAE. A epidemiologia, assim como os resultados dos parâmetros ecocardiográficos dos casos de DAE, refletiram essencialmente o predomínio da LDCVM. A duração da onda P esteve correlacionada positivamente com o grau de DAE e mostrou-se útil no seu diagnóstico. Por seu turno, o NT-proBNP não revelou utilidade na deteção de DAE (nas condições de maneio e processamento das amostras deste trabalho). As complicações de DAE detetadas traduziram aquelas descritas na literatura.
ABSTRACT - Left atrial enlargement in dogs: chronic degenerative mitral valve disease as its main cause; Integrated study of NT-proBNP biomarker - Left atrial enlargement (LAE) is a morphological cardiac change due to volume or pressure overload that accompanies most of the heart failures. There are a lot of diseases that can lead to LAE, specially the chronic degenerative mitral valve disease (CDMVD). This is the most common acquired heart disease in adult dogs and affects mainly small and medium-sized breeds. Echocardiography is considered the primary diagnostic exam of LAE because it is more sensitive than chest radiograph and electrocardiogram (ECG), which are also useful in its diagnosis. Cardiac biomarker NT-proBNP has also become useful in detecting heart disease and has already been correlated with the degree of LAE. Prognosis of LAE depends essentially on the underlying disease, duration and treatment. Complications of LAE basically include arrhythmias, pulmonary hypertension (PH), congestive heart failure (CHF) and, rarely, left atrial rupture. This dissertation addresses the aspects related to the underlying diseases, diagnosis and complications of LAE and reports a case study conducted in dogs with LAE. The main objectives of this study were: investigation of the principal diseases related to LAE in dogs and the importance of CDMVD in its prevalence; and to research the relationship between the degreeof LAE, the P-wave duration of ECG and plasma concentration of NT-proBNP (the NT-proBNP only in cases with CDMVD). The epidemiology and major complications of LAE were also investigated. Echocardiographic and electrocardiographic main parameters were collected from 54 dogs with LAE and plasma concentrations of NT-proBNP were also measured in 30 dogs with CDMVD (with and without LAE). CDMVD proved to be the main disease related to LAE. The epidemiology and the results of the echocardiographic parameters of the LAE cases reflected the predominance of CDMVD. The P wave was positively correlated with the degree of LAE and proved useful for its diagnosis. On the other hand the NT-proBNP did not show utility for the detection of LAE (measured in these handling conditions). LAE complications detected reflect those described in the literature.
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Viar, Kenneth E. II. "Role of SARM1 in Chronic Immune-Mediated Central Nervous System Inflammation." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5819.

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SARM1 is an injury-induced nicotinamide adenine dinucleotide nucleosidase (NADase) that was previously shown to promote axonal degeneration in response to traumatic, toxic, and excitotoxic stressors. This raises the question of whether a SARM1-dependent program of axonal degeneration is central to a common pathway contributing to disease burden in neurological disorders. The degree to and mechanism by which SARM1 inactivation decreases the pathophysiology of such disorders is of interest to establish the rationale to pursue SARM1 as a therapeutic target. In this study, we compare the course and pathology of experimental autoimmune encephalomyelitis (EAE) in Sarm1-knockout (KO) mice and wild-type littermates to test the contribution of SARM1-dependent axonal degeneration specifically in the context of chronic, immune-mediated central nervous system (CNS) inflammation. The question of whether SARM1 loss in Sarm1-KO mice would inhibit, promote, or have a negligible impact on EAE-induced axonal degeneration and more broadly CNS inflammation was explored using a variety of analyses: quantification of clinical score in a chronic EAE model, CNS immune infiltrate profile, axon initial segment morphology in layer V cortical neurons, axonal transport disruption and transection in the lumbar spinal cord. Additionally, we have proposed a method for detecting SARM1 activation in situusing a novel SARM1-mCitrine bimolecular fluorescence complementation (BiFC) technique. Successful implementation of such a molecular tool would allow for a detailed, mechanistic approach to enhance our understanding of upstream intracellular signals that trigger SARM1 activation.
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Schwartz, Joseph D. "The Prevalence of Comorbid Chronic Disease in Virginia's Adult Patient Population during the Years 2001 and 2004." VCU Scholars Compass, 2005. http://hdl.handle.net/10156/1553.

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García, Romero Bernardo Celso. "Estudio cualitativo del perfil del cuidador primario, sus estilos de afrontamiento y el vínculo afectivo con el enfermo oncológico infantil." Doctoral thesis, Universitat Ramon Llull, 2011. http://hdl.handle.net/10803/32141.

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La família és una peça clau en el suport del malalt durant el procés de la malaltia. No obstant això, les conseqüències psicològiques que comporta l'impacte de la malaltia i continus cures, sovint repercuteixen en la seva pròpia salut i per tant en la seva qualitat de vida. Objectiu: El present estudi analitza les principals necessitats del cuidador primari, així com les motivacions per a l'adquisició del rol i el manteniment de la cura. S'han identificat les principals estratègies d'afrontament que empren els cuidadors al llarg del procés de la malaltia per fer front a l'impacte de l'estrès, així com l'anàlisi del vincle afectiu que el cuidador manté amb el malalt. Metodologia: A través d'un estudi qualitatiu de tall transversal es van realitzar 35 entrevistes individuals i 10 grups focals. Es va comptar amb la participació de 26 dones i 9 homes amb una mitjana de 34 anys, tots ells cuidadors primaris de nens i nenes amb càncer albergats en un centre d'atenció que ofereix ajuda a malalts infantils de càncer de l'occident de Mèxic. Resultats: El perfil del cuidador primari correspon, principalment a dones, amb un nivell educatiu mitjà, casades i d'un estrat socioeconòmic baix, que exerceixen el seu rol de cuidadores i de mestresses de casa. La motivació de la cura està associada a sentiments amor, deure i altruisme. La majoria dels cuidadors empraven estratègies d'afrontament centrades en l'emoció i mantenien un vincle de tipus segur amb el malalt.
La familia es una pieza clave en el apoyo del enfermo durante el proceso de la enfermedad. Sin embargo, las consecuencias psicológicas que conlleva el impacto de la enfermedad y continuos cuidados, a menudo repercuten en su propia salud y por ende en su calidad de vida. Objetivo: El presente estudio analiza las principales necesidades del cuidador primario, así como las motivaciones para la adquisición del rol y el mantenimiento del cuidado. Se han identificado las principales estrategias de afrontamiento que emplean los cuidadores a lo largo del proceso de la enfermedad para hacer frente al impacto del estrés, así como el análisis del vínculo afectivo que el cuidador mantiene con el enfermo. Metodología: A través de un estudio cualitativo de corte transversal se realizaron 35 entrevistas individuales y 10 grupos focales. Se contó con la participación de 26 mujeres y 9 hombres con una media de 34 años, todos ellos cuidadores primarios de niños y niñas con cáncer albergados en un centro de atención que brinda ayuda a enfermos infantiles de cáncer del occidente de México. Resultados: El perfil del cuidador primario corresponde, principalmente a mujeres, con un nivel educativo medio, casadas y de un estrato socioeconómico bajo, que ejercen su rol de cuidadoras y de amas de casa. La motivación del cuidado está asociada a sentimientos amor, deber y altruismo. La mayoría de los cuidadores empleaban estrategias de afrontamiento centradas en la emoción y mantenían un vínculo de tipo seguro con el enfermo.
The family is essential in supporting the patient during the disease process. However, the psychological consequences that entails the impact of the disease and ongoing care, often affect their own health and quality of life. Objective: This study analyzes the main needs of primary caregiver, and the reasons for the acquisition and maintenance of the role of care. The study has identified the main coping strategies used by caregivers throughout the disease process to face the impact of stress and the attachment between the caregiver and the patient. Methodology: Through a cross-sectional qualitative study was conducted 35 individual interviews and 10 reflective groups. It was attended by 26 women and 9 men with an average of 34 years, all primary caregivers of children housed in a cancer care center that provides assistance to children of cancer patients in western Mexico. Results: The primary caregiver profile corresponds mainly to women, with an average educational level and a low socioeconomic status who carry out their role as caregivers and homemakers. The motivation of care is associated with feelings love, obligation and altruism. Most caregivers used coping strategies focused on emotion and had a positive and safe attachment with the patient.
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Berling, Holm Katarina. "The Chorda Tympani Nerve : Role in Taste Impairment in Middle Ear Disease and after Ear Surgery." Doctoral thesis, Uppsala universitet, Centrum för klinisk forskning, Västerås, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316591.

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The chorda tympani nerve, also known as the taste nerve, runs uncovered through the middle ear cavity, a localization that exposes the nerve to pathological processes and surgical trauma in the middle ear. People operated on for otosclerosis tend to complain more about postoperative taste disturbances than those operated on for chronic otitis media. It has been suggested that this difference may be explained by gradual deterioration of chorda tympani nerve function caused by chronic otitis media infection and that further impairment caused by surgery is less noticeable in these patients. This thesis aimed to evaluate the function of the chorda tympani nerve, the effects of middle ear disease on taste and complications resulting from ear surgery for chronic otitis media or otosclerosis. This information will help to improve the ear surgeon’s ability to predict the prognosis of iatrogenic taste disturbances in patients with middle ear disease and after ear surgery. Taste was assessed using electrogustometry and the filter paper disc method before and after surgery for chronic otitis media or otosclerosis. Patients also completed questionnaires about symptoms and quality of life. The status of the chorda tympani nerve upon surgical opening of the ear and grading of the trauma to the nerve during the surgery were recorded. The ultrastructure of the chorda tympani nerve from healthy ears and from ears with chronic otitis media was examined. Electrogustometry and the filter paper disc method were evaluated. The results of electrogustometry and the filter paper disc method were highly reproducible, although their correlation was moderate. Patients with chronic otitis media, patients with a more traumatized nerve, female patients and younger patients were more likely to report postoperative taste disturbances. Most of the patients recovered their taste after 1 year. The quality of life study showed only minor changes after surgery. Electron microscopic observations of nerves from ears with chronic otitis media showed signs of structural degeneration, although signs of regeneration, such as sprouting were also observed. This results may explain the recovery of taste postoperatively and indicate that the nerve should be carefully handled during surgery.
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Ramalho, Reinaldo Flávio da Costa. "Qualidade de vida visual em pacientes com degeneração macular relacionada à idade neovascular tratados com antiangiogênicos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-24102018-135624/.

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INTRODUÇÃO: A degeneração macular relacionada à idade (DMRI) é a principal causa de perda de visão irreversível e cegueira mundialmente. A perda da visão central interfere nas atividades de vida diária, como o reconhecimento facial, leitura e escrita, direção de veículos automotores e em atividades funcionais e de lazer. Esta perda de visão relaciona-se também com o desencadeamento de quadros de ansiedade e depressão. Este estudo avaliou a qualidade de vida visual em pacientes com degeneração macular relacionada à idade neovascular por meio do questionário de função visual 25-item National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25). MÉTODOS: Estudo clínico observacional de 87 pacientes de ambos os sexos, com idade >= 50 anos e com o diagnóstico de DMRI neovascular unilateral ou bilateral. Todos os pacientes responderam ao questionário de função visual NEI VFQ- 25 no final do tratamento em regime Tratar e Estender ou PrONTO, com as drogas antiangiogênicas ranibizumabe ou aflibercepte. RESULTADOS: A idade dos pacientes foi a variável que menos influenciou a qualidade de vida visual dos pacientes. O gênero teve uma influência um pouco maior que a idade, no entanto, a lateralidade da doença demonstrou maior influência na qualidade de vida visual, comparada ao gênero e idade dos pacientes e foi significante para oito dos 12 domínios do questionário de função visual NEI VFQ-25. Os pacientes com acometimento bilateral tiveram pontuações mais baixas que os com doença unilateral em todos os domínios do questionário. A acuidade visual corrigida (AVc) foi a variável que apresentou o maior número de domínios com valores significantes e, portanto, foi a variável que mais se correlacionou com a qualidade de vida visual. A AVc do melhor olho (MO) foi significante para a maioria dos domínios relacionados com a visão, ao contrário do pior olho (PO) que não foi significante para nenhum domínio do questionário. CONCLUSÃO: Todas as variáveis testadas afetaram a qualidade de vida visual dos pacientes, onde a lateralidade teve uma maior influência, seguida pela idade e sexo dos pacientes. Na tomada de decisão para o tratamento de pacientes com DMRI neovascular, pelo menos para esta população, a manutenção da AVc do MO >= 0,5 (escala decimal de Snellen) foi essencial para a manutenção de boa qualidade de vida visual, independente da AVc do PO, que não teve efeito significante em nenhum domínio do questionário de função visual NEI VFQ-25
INTRODUCTION: The neovascular age-related macular degeneration (AMD) is the main cause of irreversible loss of vision and blindness woldwide. The loss of the central visual field interferes on daily activities such as facial recognition, reading and writing, driving as well as functional and leasure activities. This loss of vision may also increases anxiety and depression for this age group. To evaluate the impact of neovascular AMD on the visual quality of life of patients using the 25-item National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25). METHODS: This was an observational clinical, with 87 patients of both genders, with age >= 50 years and a clinical diagnosis of unilateral or bilateral neovascular age related macular degeneration. All patients answered the visual functioning questionaire NEI VFQ-25 at the end of the treatment with the Treat and Extend or PrONTO regimen using antiangiogenic drugs ranibizumab or aflibercept. RESULTS: The age of patients was the variable with the lower influence on the quality of life of the patients. Gender had an influence slightly higher then the age, however, the laterality of the disease had the highest influence on the quality of life, compared with age and gender, and was significant for 8 of the 12 domains of the visual functioning questionaire NEI VFQ-25. The patients with bilateral age-related macular degeneration had lower scores than patients with unilateral disease for all domains of the questionaire. Visual acuity was the variable with the higher number of domains with significant values, and therefore the variable with the higher correlation with the quality of life. The visual acuity of the best eye (BE) was significant for most of the vision related domains, in opposition the the visual acuity of the worst eye (WE) which was not significant for any domain of the questionaire. CONCLUSION: All variables tested affected the visual quality of life, where the laterality of the disease had the highest influence, followed by the age and gender of the patients. The decision process for the treatment of patients with neovascular AMD, at least for this population, keeping the visual acuity of the BE >= 0,5 (Snellen\'s decimal scale) was essential to maintain a long term quality of life, despite the visual acuity of the worst eye, that had no significant effect on any domain of the visual functioning quaestionaire NEI VFQ-25
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Books on the topic "Chronic degenerative disease"

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Reversibility of chronic degenerative disease and hypersensitivity. Boca Raton: Taylor & Francis Group, 2010.

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Rea, William J. Reversibility of chronic degenerative disease and hypersensitivity. Boca Raton, Fla: CRC Press, 2010.

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Appleton, Nancy. Stopping inflammation: Relieving the cause of degenerative diseases. Garden City Park, N.Y: Square One Publishers, 2004.

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De algo se tiene uno que morir...: Una perspectiva sociocultural de las ECD (enfermedades crónico degenerativas). México, DF: Instituto Politécnico Nacional, 2012.

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Hale, Mary. The immune support cookbook: Easy, delicious recipes to support your health if you're HIV positive or suffer from CFIDS, cancer or other degenerative diseases. Secaucus, NJ: Carol Pub. Group, 1995.

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Ken'ichi, Kitani, Goto S, and Aoba A, eds. Pharmacological intervention in aging and age-associated disorders: Proceedings of the Sixth Congress of the International Association of Biomedical Gerontology. New York: New York Academy of Sciences, 1996.

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Rea, William J. Reversibility of Chronic Degenerative Disease Vol. 3: Diagnostic Considerations. Taylor & Francis Group, 2014.

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Singer, Michael A. Are Chronic Degenerative Diseases Part of the Ageing Process?: Insights from Comparative Biology. Nova Science Publishers, Incorporated, 2013.

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Singer, Michael A. Are Chronic Degenerative Diseases Part of the Ageing Process?: Insights from Comparative Biology. Nova Science Publishers, Incorporated, 2015.

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McCabe, John. Heart Disease, Diabetes, and Cancer Prevention: How to Avoid Those and Other Common Chronic and Degenerative Illnesses. Carmania Books, 2016.

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Book chapters on the topic "Chronic degenerative disease"

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Egwuagu, Charles E. "Chronic Intraocular Inflammation and Development of Retinal Degenerative Disease." In Retinal Degenerative Diseases, 417–25. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-3209-8_53.

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Jirovec, Mary Marmoll. "Urine Control in Patients with Chronic Degenerative Brain Disease." In Alzheimer’s Disease, 235–47. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4615-6414-0_24.

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Tucker, Amy J., Branden Deschambault, and Marica Bakovic. "Nutritional Genomics: Fundamental Role of Diet in Chronic Disease Prevention and Control." In Functional Foods, Nutraceuticals, and Degenerative Disease Prevention, 45–74. Oxford, UK: Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9780470960844.ch3.

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Zhang, Hua, Ming Fan, and Gopinadhan Paliyath. "Effects of Carotenoids and Retinoids on Immune-Mediated Chronic Inflammation in Inflammatory Bowel Disease." In Functional Foods, Nutraceuticals, and Degenerative Disease Prevention, 213–33. Oxford, UK: Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9780470960844.ch8.

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Meldrum, B. S. "Excitatory Amino Acids in Epilepsy and in Acute and Chronic Neuronal Degenerative Disorders." In Amino Acid Availability and Brain Function in Health and Disease, 325–32. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73175-4_29.

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Campbell, T. Colin, and Junshi Chen. "Diet and Chronic Degenerative Diseases." In Western Diseases, 67–118. Totowa, NJ: Humana Press, 1994. http://dx.doi.org/10.1007/978-1-4684-8136-5_4.

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Bush, Ashley I., and Lee E. Goldstein. "Specific Metal-Catalysed Protein Oxidation Reactions in Chronic Degenerative Disorders of Ageing: Focus on Alzheimer's Disease and Age-Related Cataracts." In Ageing Vulnerability: Causes and Interventions, 26–43. Chichester, UK: John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470868694.ch4.

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Petrolati, Sandro, and Fabio Ferrari. "Chronic-Degenerative Diseases in Sub-Saharan Africa." In TELe-Health, 17–24. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-72763-9_2.

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Ranchon, Isabelle, Jeremy White, Sherry Chen, Kathleen Alvarez, Yashige Kotake, and Robert E. Anderson. "Chronic Administration of Phenyl N-TERT- Butylnitrone Protects the Retina Against Light Damage." In New Insights Into Retinal Degenerative Diseases, 95–103. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1355-1_11.

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Oschman, James L. "Overcoming Chronic and Degenerative Diseases with Energy Medicine 1." In Nutrition and Integrative Medicine, 641–86. Boca Raton : Taylor & Francis, 2018.: CRC Press, 2018. http://dx.doi.org/10.1201/9781315153155-27.

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Conference papers on the topic "Chronic degenerative disease"

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Ruberté, Lissette M., Raghu Natarajan, and Gunnar B. J. Andersson. "Biomechanical Effect of Lumbar Disc Degeneration Under Flexion/Extension: A Finite Element Model Study." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176190.

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Degenerative disc disease (DDD) is a progressive pathological condition observed in 60 to 80% of the population [1]. It involves changes in both the biochemistry and morphology of the intervertebral disc and is associated with chronic low back pain, sciatica and adult scoliosis [2,3]. The most accepted theory of the effects of DDD on the kinematics of the spine is that proposed by Kirkaldy-Willis and Farfan which states that the condition initiates as a temporary dysfunction, followed by instability and then re-stabilization as the disease progresses [4]. Although there is no clear relationship between disc degeneration and the mechanical behavior of the lumbar spine, abnormal motion patterns either in the form of increased motion or erratic motion have been reported from studies on human cadaveric motion segments [5,6]. To date however no study has looked at how disc degeneration affects the adjacent segment mechanics. IN vivo testing is difficult for these purposes given that specimens are generally obtained from people at the later stages of life and consequently often display multiple pathologies. A finite element model is a viable alternative to study the mechanics of the segments adjacent to the diseased disc. It is hypothesized that moderate degeneration at one level will alter the kinematics of the whole lumbar spine.
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Spratley, Edward M., Erika A. Matheis, Curtis W. Hayes, Robert S. Adelaar, and Jennifer S. Wayne. "Patient Specific Modeling of a Stage II Flatfoot Population." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14165.

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Adult Acquired Flatfoot Deformity (AAFD) is a degenerative disease characterized by chronic changes in the joint alignment of the bones of the foot leading to significant pain and dysfunction. The hallmark of this disease is the functional loss in posterior tibialis tendon (PTT) strength though mechanical degradation of passive support structures of the foot have also been implicated, namely the spring ligament, talocalcaneal interosseous ligaments, fibers of the anterior deltoid, and the long and short plantar ligaments. [1] Clinically, AAFD patients present with midfoot collapse, forefoot abduction, and valgus tilting of the hindfoot and the magnitudes of these deformities are most often graded using plane radiographs in the mediolateral (ML), oblique anteroposterior (AP) and posteroanterior (PA) views. [1–3] The objective of this study was to develop a population of patient-matched rigid-body kinematic models using a standardized methodology that can be used to predict pathologic foot function with agreement between patient and model assessed through clinically relevant radiographic joint angles.
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Ihnatouski, Mikhail, Dmitriy Karev, Boris Karev, Jolanta Pauk, and Kristina Daunoravičienė. "AFM investigation of hyaline cartilage’s surface destruction." In Biomdlore. VGTU Technika, 2016. http://dx.doi.org/10.3846/biomdlore.2016.15.

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Introduction: Osteoarthritis is a chronic, progressive disease. The aim of this paper is presenting the AFM investigation of cartilage in relation to the assessment of degenerative changes in the surface of hyaline cartilage. It can be useful in choosing the most effective methods of therapy. Methods: Samples were taken from the cartilage surface of the femoral head after its removal during total hip arthroplasty. Images of the surface of the sample were obtained using an optical microscope equipped with a digital video camera, in the reflected light and by atomic force microscopy. Results: The longitudinal orientation of the collagen fibers and sub-fibers beams on the surface, up to a diameter of 50 nm are identified in non-destroyed area sites. Conclusions: Images of the destroyed areas displaying separately passing collagen fibers, strongly exposed to the surface: the size measured and found substructure.
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Spratley, E. Meade, Erika A. Matheis, Curtis W. Hayes, Robert S. Adelaar, and Jennifer S. Wayne. "Patient Specific Modeling of Stage II Flatfoot Deformity Before and After Surgical Correction." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80366.

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Adult Acquired Flatfoot Deformity (AAFD) is a degenerative disease characterized by chronic changes in the joint alignment of the bones of the foot leading to significant pain and dysfunction. The early stages of the disease are thought to involve primarily the mechanical degradation of the soft-tissue support structures of the foot, namely the spring ligament, talocalcaneal interosseous ligaments, fibers of the anterior deltoid, and the long and short plantar ligaments, as well as a functional loss in posterior tibialis tendon (PTT) strength. [1] These changes manifest clinically as midfoot collapse, forefoot abduction, and valgus tilting hindfoot. [1–3] Various surgical corrections exist for Stage II AAFD to restore more normal biomechanical function to the foot. Treatment selection is most often based on clinical outcomes and surgeon preference. However, the optimal procedure(s) for an individual patient is unknown. Computer Aided Design (CAD) approaches offer advantages for evaluating foot function as well as the ability to predict pre-operatively the outcome of corrective procedures. This study developed a 3D patient specific computer model of the lower leg from a diagnosed Stage II flatfoot patient and evaluated its ability to predict foot function pre- and post-operatively through agreement with clinically relevant radiographic joint angles.
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Howell, Eric B., Glenn Klute, and Santosh Devasia. "Passive and Active Shock Absorbing Prostheses for Lower Limb Amputees." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-81286.

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Excessive transient forces arising from foot-ground during gait can be related to increased incidence of degenerative joint disease, residual limb blisters and ulceration, muscle tears, stress fractures, and chronic low back pain. For the lower extremity amputee with only residual capacity to attenuate transient forces, effective protective interventions are an essential element of the prosthetic prescription. To facilitate understanding of the components and design variables that may influence shock absorption, a lumped parameter model simulating the movement of the human body, prosthetic components, and footwear for the first 150 ms following initial foot-ground contact is developed in conjunction with a cost function relating dose, magnitude and frequency with adverse health effects. The prosthetic foot was found to have the greatest potential for attenuating impact forces compared to the pylon and socket liner. Using the model to explore the design space, optimal passive designs were able to reduce the adverse-health-effects, cost function by 20% from those of seven different, commercially available, prosthetic feet. Optimal passive designs at the pylon and socket liner produced smaller reductions in cost while at the same time creating undesirably large displacements that could potentially lead to asymmetrical gait and secondary disabilities. While optimal passive designs were able to provide a significant cost reduction over existing prosthetic feet, further exploration of the design space reveals active shock absorbing feet have the potential to reduce the adverse health effects cost function by 57%.
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Cox, L. G. E., C. C. van Donkelaar, B. van Rietbergen, and K. Ito. "Mechanoregulated Bone Remodeling May Explain Bone Structural Changes Observed in Osteoarthritis." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19583.

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Osteoarthritis (OA) affects both the articular cartilage and the subchondral bone. It is a complicated disease, associated with conditions varying from obesity and strenuous exercise to joint malalignment, anterior cruciate ligament (ACL) injury, and even metabolic bone diseases. Patients suffer from chronic joint pain and limitation of motion, and no cure is yet available. For many years, medical therapies have been focused on cartilage, because bone changes were thought not to play a major role in the OA disease process. However, it has been shown that bone changes occur in an early stage of OA, and that alterations to subchondral bone can lead to cartilage degeneration [1]. Therefore, currently the bone is considered as a therapeutic target as well.
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Cocco, Pierluigi. "1659c Cancer and other chronic degenerative diseases following long term exposure to pesticides." In 32nd Triennial Congress of the International Commission on Occupational Health (ICOH), Dublin, Ireland, 29th April to 4th May 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/oemed-2018-icohabstracts.1332.

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Leopold, Johannes, Luka Brcic, Sylvia Eidenhammer, Wim Timens, and Helmut H. Popper. "Degeneration of nerve fibers in chronic obstructive lung disease and usual interstitial pneumonia." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.2899.

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Vergara-Castañeda, Haydé, Rocio Campos-Vega, and Hector Pool. "Micro and nanoencapsulation: a new hope to combat the effects of chronic degenerative diseases." In Foods: Bioactives, Processing, Quality and Nutrition. Basel, Switzerland: MDPI, 2013. http://dx.doi.org/10.3390/bpqn2013-01191.

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Donaubauer, A.-J., T. Gryc, I. Becker, OJ Ott, R. Fietkau, US Gaipl, and B. Frey. "P155 IMMO-LDRT01 trial: immunomodulatory effects of low dose radiation therapy of chronic degenerative and inflammatory diseases." In 39th European Workshop for Rheumatology Research, 28 February–2 March 2019, Lyon, France. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2018-ewrr2019.137.

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