Journal articles: 'Chronic degenerative disease'

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&NA;. "Chronic Pain a Degenerative Disease?" Lippincott's Bone and Joint Newsletter 16, no. 2 (February 2010): 21–22. http://dx.doi.org/10.1097/01.bonej.0000367962.07481.7b.

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&NA;. "Chronic Pain a Degenerative Disease?" Back Letter 24, no. 12 (December 2009): 137. http://dx.doi.org/10.1097/00130561-200912000-00006.

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Di Renzo, Laura, Paola Gualtieri, and Antonino De Lorenzo. "Diet, Nutrition and Chronic Degenerative Diseases." Nutrients 13, no. 4 (April 20, 2021): 1372. http://dx.doi.org/10.3390/nu13041372.

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Chronic degenerative diseases (CDDs), represented mainly by obesity, cardiovascular disease (CVD), diabetes, chronic kidney disease (CKD), inflammatory bowel diseases, osteoporosis, sarcopenia, neurodegenerative diseases such as Huntington’s disease (HD), rheumatoid arthritis (RA), chronic respiratory diseases, and many cancers, have been, up to now, the most frequent causes of prolonged disability and death worldwide [...]

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Madeira, Maria H., Raquel Boia, Paulo F. Santos, António F. Ambrósio, and Ana R. Santiago. "Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases." Mediators of Inflammation 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/673090.

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Retinal degenerative diseases are major causes of vision loss and blindness worldwide and are characterized by chronic and progressive neuronal loss. One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. There is growing evidence that retinal microglia, as in the brain, become activated in the course of retinal degenerative diseases, having a pivotal role in the initiation and propagation of the neurodegenerative process. A better understanding of the events elicited and mediated by retinal microglia will contribute to the clarification of disease etiology and might open new avenues for potential therapeutic interventions. This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.

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Di Nicola, V. "Degenerative osteoarthritis a reversible chronic disease." Regenerative Therapy 15 (December 2020): 149–60. http://dx.doi.org/10.1016/j.reth.2020.07.007.

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Andari, Fatmi, and Tria Damayanti. "Role of Mesenchymal Stem Cells In Chronic Obstructive Lung Disease." Respiratory Science 1, no. 3 (June 23, 2021): 202–12. http://dx.doi.org/10.36497/respirsci.v1i3.26.

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Therapy for Chronic Obstructive Pulmonary Disease (COPD) is currently still not giving effect to tissue repair and regeneration. Chronic Obstructive Pulmonary Disease is still a progressive degenerative disease. Stem cells through their regenerative ability offer a new promising alternative therapy for the management of degenerative diseases including COPD. There have been many studies conducted to determine the safety and efficacy of stem cells in COPD. Published research about stem cells on COPD is still in phase II. Further research is needed on a larger scale before stem cells can be widely applied in the management of COPD. Stem cells are a very promising alternative therapy and are a big leap in the medical world for degenerative diseases including COPD.

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Kim, Jun, Hong Lan Jin, Dae Sik Jang, Kwang Won Jeong, and Se-Young Choung. "Quercetin-3-O-α-l-arabinopyranoside protects against retinal cell death via blue light-induced damage in human RPE cells and Balb-c mice." Food & Function 9, no. 4 (2018): 2171–83. http://dx.doi.org/10.1039/c7fo01958k.

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Olszewer, Efrain, and James P. Carter. "EDTA chelation therapy in chronic degenerative disease." Medical Hypotheses 27, no. 1 (September 1988): 41–49. http://dx.doi.org/10.1016/0306-9877(88)90082-5.

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Tai TC Huang, HP. "Echocardiographic assessment of right heart indices in dogs with elevated pulmonary artery pressure associated with chronic respiratory disorders, heartworm disease, and chronic degenerative mitral valvular disease." Veterinární Medicína 58, No. 12 (December 20, 2013): 613–20. http://dx.doi.org/10.17221/7180-vetmed.

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The aim of this study was to evaluate right ventricular (RV) remodeling and right heart failure associated with different causes of elevated pulmonary arterial pressure (PAP) in dogs. In total, 169 client-owned dogs with tricuspid regurgitation (TR) and 40 client-owned clinically healthy dogs were included. Dogs with TR were further categorised as suffering from chronic respiratory disorders (CRD), heartworm disease (HWD), mild/moderate chronic degenerative mitral valvular disease (CDMD), and severe CDMD. Among the echocardiographic indices of the right heart, no significant difference in the tricuspid annular plane systolic excursion to aortic root diameter ratio was found among the clinical healthy controls and the four different TR categories. No significant differences in TR peak velocity and pulmonic regurgitation peak velocity were found among dogs in the four different TR categories. The ratio of the right to left ventricular basal diameter in the right ventricular-focused view was significantly higher in dogs with chronic respiratory disorders and dogs with heartworms. Left ventricular compression quantified using the eccentricity index and the ratio of the main pulmonary artery to aortic root diameter were significantly higher in dogs with HWD. Their right ventricular acceleration to ejection time (AT/ET) was significantly lower in dogs with HWD. Based on these findings, we conclude that right heart indices are affected by CRD, HWD, and moderate to severe CDMD. However, right heart indices derived from left heart measurements might be underestimated in dogs with CDMD.

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Choi, Keum Hwa, Gail Buhl, and Julia Ponder. "Raptor Acupuncture for Treating Chronic Degenerative Joint Disease." Journal of Acupuncture and Meridian Studies 9, no. 6 (December 2016): 330–34. http://dx.doi.org/10.1016/j.jams.2016.09.020.

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James, Rachel. "Chronic degenerative valvular disease - where are we now?" Journal of Small Animal Practice 50 (September 2009): 1–2. http://dx.doi.org/10.1111/j.1748-5827.2009.00824.x.

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Di Renzo, Laura, Paola Gualtieri, Lorenzo Romano, Giulia Marrone, Annalisa Noce, Alberto Pujia, Marco Alfonso Perrone, Vincenzo Aiello, Carmela Colica, and Antonino De Lorenzo. "Role of Personalized Nutrition in Chronic-Degenerative Diseases." Nutrients 11, no. 8 (July 24, 2019): 1707. http://dx.doi.org/10.3390/nu11081707.

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Human nutrition is a branch of medicine based on foods biochemical interactions with the human body. The phenotypic transition from health to disease status can be attributed to changes in genes and/or protein expression. For this reason, a new discipline has been developed called “-omic science”. In this review, we analyzed the role of “-omics sciences” (nutrigenetics, nutrigenomics, proteomics and metabolomics) in the health status and as possible therapeutic tool in chronic degenerative diseases. In particular, we focused on the role of nutrigenetics and the relationship between eating habits, changes in the DNA sequence and the onset of nutrition-related diseases. Moreover, we examined nutrigenomics and the effect of nutrients on gene expression. We perused the role of proteomics and metabolomics in personalized nutrition. In this scenario, we analyzed also how dysbiosis of gut microbiota can influence the onset and progression of chronic degenerative diseases. Moreover, nutrients influencing and regulating gene activity, both directly and indirectly, paves the way for personalized nutrition that plays a key role in the prevention and treatment of chronic degenerative diseases.

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Smith, Paul. "Management of chronic degenerative mitral valve disease in dogs." In Practice 28, no. 7 (July 2006): 376–83. http://dx.doi.org/10.1136/inpract.28.7.376.

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Eser, Olcay, Cengiz Gomleksiz, Mehdi Sasani, Tunc Oktenoglu, Ahmet Levent Aydin, Yaprak Ataker, Tuncer Suzer, and Ali Fahir Ozer. "Dynamic Stabilisation in the Treatment of Degenerative Disc Disease with Modic Changes." Advances in Orthopedics 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/806267.

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Objective. Posterior dynamic stabilization is an effective alternative to fusion in the treatment of chronic instability and degenerative disc disease (DDD) of the lumbar spine. This study was undertaken to investigate the efficacy of dynamic stabilization in chronic degenerative disc disease with Modic types 1 and 2. Modic types 1 and 2 degeneration can be painful. Classic approach in such cases is spine fusion. We operated 88 DDD patients with Modic types 1 and 2 via posterior dynamic stabilization. Good results were obtained after 2 years of followup.Methods. A total of 88 DDD patients with Modic types 1 and 2 were selected for this study. The patients were included in the study between 2004 and 2010. All of them were examined with lumbar anteroposterior (AP) and lateral X-rays. Lordosis of the lumbar spine, segmental lordosis, and ratio of the height of the intervertebral disc spaces (IVSs) were measured preoperatively and at 3, 12, and 24 months after surgery. Magnetic resonance imaging (MRI) analysis was carried out, and according to the data obtained, the grade of disc degeneration was classified. The quality of life and pain scores were evaluated by visual analog scale (VAS) score and Oswestry Disability Index (ODI) preoperatively and at 3, 12, and 24 months after surgery. Appropriate statistical method was chosen.Results. The mean 3- and 12-month postoperative IVS ratio was significantly greater than that of the preoperative group (P<0.001). However, the mean 1 and 2 postoperative IVS ratio was not significantly different (P>0.05). Furthermore, the mean preoperative and 1 and 2 postoperative angles of lumbar lordosis and segmental lordosis were not significantly different (P>0.05). The mean VAS score and ODI, 3, 12, and 24 months after surgery, decreased significantly, when compared with the preoperative scores in the groups (P=0.000).Conclusion. Dynamic stabilization in chronic degenerative disc disease with Modic types 1 and 2 was effective.

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Ashok, Ajay, Neena Singh, Suman Chaudhary, Vindhya Bellamkonda, Alexander E. Kritikos, Aaron S. Wise, Neil Rana, Dallas McDonald, and Rithvik Ayyagari. "Retinal Degeneration and Alzheimer’s Disease: An Evolving Link." International Journal of Molecular Sciences 21, no. 19 (October 2, 2020): 7290. http://dx.doi.org/10.3390/ijms21197290.

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Age-related macular degeneration (AMD) and glaucoma are degenerative conditions of the retina and a significant cause of irreversible blindness in developed countries. Alzheimer’s disease (AD), the most common dementia of the elderly, is often associated with AMD and glaucoma. The cardinal features of AD include extracellular accumulation of amyloid β (Aβ) and intracellular deposits of hyper-phosphorylated tau (p-tau). Neuroinflammation and brain iron dyshomeostasis accompany Aβ and p-tau deposits and, together, lead to progressive neuronal death and dementia. The accumulation of Aβ and iron in drusen, the hallmark of AMD, and Aβ and p-tau in retinal ganglion cells (RGC), the main retinal cell type implicated in glaucoma, and accompanying inflammation suggest overlapping pathology. Visual abnormalities are prominent in AD and are believed to develop before cognitive decline. Some are caused by degeneration of the visual cortex, while others are due to RGC loss or AMD-associated retinal degeneration. Here, we review recent information on Aβ, p-tau, chronic inflammation, and iron dyshomeostasis as common pathogenic mechanisms linking the three degenerative conditions, and iron chelation as a common therapeutic option for these disorders. Additionally discussed is the role of prion protein, infamous for prion disorders, in Aβ-mediated toxicity and, paradoxically, in neuroprotection.

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Karppinen, Jaro, Francis H. Shen, Keith D. K. Luk, Gunnar B. J. Andersson, Kenneth M. C. Cheung, and Dino Samartzis. "Management of Degenerative Disk Disease and Chronic Low Back Pain." Orthopedic Clinics of North America 42, no. 4 (October 2011): 513–28. http://dx.doi.org/10.1016/j.ocl.2011.07.009.

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Doll, R. "Chronic and degenerative disease: major causes of morbidity and death." American Journal of Clinical Nutrition 62, no. 6 (December 1, 1995): 1301S—1305S. http://dx.doi.org/10.1093/ajcn/62.6.1301s.

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Magee, Wendy L., and Jane W. Davidson. "Singing in Therapy: Monitoring Disease Process in Chronic Degenerative Illness." British Journal of Music Therapy 18, no. 2 (December 2004): 65–77. http://dx.doi.org/10.1177/135945750401800205.

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Veurink, Gerald, George Perry, and Sandeep Kumar Singh. "Role of antioxidants and a nutrient rich diet in Alzheimer's disease." Open Biology 10, no. 6 (June 2020): 200084. http://dx.doi.org/10.1098/rsob.200084.

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The joint attack on the body by metabolic acidosis and oxidative stress suggests that treatment in degenerative diseases, including Alzheimer's disease (AD), may require a normalizing of extracellular and intracellular pH with simultaneous supplementation of an antioxidant combination cocktail at a sufficiently high dose. Evidence is also accumulating that combinations of antioxidants may be more effective, taking advantage of synergistic effects of appropriate antioxidants as well as a nutrient-rich diet to prevent and reverse AD. This review focuses on nutritional, nutraceutical and antioxidant treatments of AD, although they can also be used in other chronic degenerative and neurodegenerative diseases.

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Nagrik, Shatrughna Uttam, Prashant Arun Patil, Deepak M. Nagrik, Vinayak Zagare, Priyamala Avchar, Samiksha Bahurupi, and Shubhangi Ambhore. "Herbal drugs Used on Parkinson Disease." Journal of Drug Delivery and Therapeutics 10, no. 4-s (August 15, 2020): 235–39. http://dx.doi.org/10.22270/jddt.v10i4-s.4286.

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Parkinson's disease (PD) is the world's most widespread chronic neuron degenerative motion condition affecting more than 10 million people. The characteristic hallmark of PD involves a progressive loss of doperminergic neuron in the brain's Subetantia Nigra. Considerable Beware of this paid recently to the Bio-friendly Usage plant-based products for neuron prevention, cure and treatment Disease and is degenerative. The herbal drugs therefore are safer than other drugs. Herbal medicine has its roots in ancient civilizations. It includes the usage of medicinal plants to cure disease and enhance general wellbeing. Keywords: Parkinson, Herbal Drug Treatment, Ayurveda

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McGeer, P. L., E. G. McGeer, T. Kawamata, T. Yamada, and H. Akiyama. "Reactions of the Immune System in Chronic Degenerative Neurological Diseases." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 18, S3 (August 1991): 376–79. http://dx.doi.org/10.1017/s0317167100032479.

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ABSTRACT:Elements consistent with a cell mediated immune response were identified immunohistochemically in amyotrophic lateral sclerosis (ALS) spinal cord and Alzheimer disease (AD) hippocampus. T helper/inducer and cytotoxic/suppressor lymphocytes were detected in affected tissues in both diseases. In addition, abundant reactive microglia were found expressing the major histocompatibility glycoproteins HLA-A,B,C and HLA-DR, as well as receptors for the Fc chain (Fcyγl), for complement 3 and 4, and for vitronectin. In AD, the complement proteins Clq, C4d, C3d and C5b-9 were found on dystrophic neurites, neuropile threads and some neurofibrillary tangles. In ALS, the only complement proteins identified were C4d and C3d. The integrin ligands vitronectin and ICAM-1 were also identified in affected tissues in both diseases.

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Brachet, Patrick, Aurélie Chanson, Christian Demigné, Frédérique Batifoulier, Marie-Cécile Alexandre-Gouabau, Viviane Tyssandier, and Edmond Rock. "Age-associated B vitamin deficiency as a determinant of chronic diseases." Nutrition Research Reviews 17, no. 1 (June 2004): 55–68. http://dx.doi.org/10.1079/nrr200478.

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The number of elderly individuals is growing rapidly worldwide and degenerative diseases constitute an increasing problem in terms of both public health and cost. Nutrition plays a role in the ageing process and there has been intensive research during the last decade on B vitamin-related risk factors in vascular and neurological diseases and cancers. Data from epidemiological studies indicate that subclinical deficiency in most water-soluble B vitamins may occur gradually during ageing, possibly due to environmental, metabolic, genetic, nutritional and pathological determinants, as well as to lifestyle, gender and drug consumption. Older adults have distinct absorption, cell transport and metabolism characteristics that may alter B vitamin bioavailability. Case–control and longitudinal studies have shown that, concurrent with an insufficient status of certain B vitamins, hyperhomocysteinaemia and impaired methylation reactions may be some of the mechanisms involved before a degenerative pathology becomes evident. The question that arises is whether B vitamin inadequacies contribute to the development of degenerative diseases or result from ageing and disease. The present paper aims to give an overview of these issues at the epidemiological, clinical and molecular levels and to discuss possible strategies to prevent B vitamin deficiency during ageing.

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A, Sandhya, and Gomathi Kannayiram. "ALZHEIMER’S DISEASE THERAPEUTIC APPROACHES." Asian Journal of Pharmaceutical and Clinical Research 11, no. 7 (July 7, 2018): 17. http://dx.doi.org/10.22159/ajpcr.2018.v11i7.25104.

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A protein is a large biomolecule which consists of one or more chains of amino acid residues. Proteins exhibit a biological phenomenon in which, they are misfolded as aggregates (i.e., accumulate and clump together) either intra- or extracellularly. This process plays a central role in the pathogenesis of Alzheimer’s disease (AD) and diabetes mellitus (DM) - 2 and common for many degenerative diseases. In this case, the histopathological consequences of protein misfolding such as sensile plaques and neurofibrillary tangles in AD and lewy bodies in Parkinson’s disease occur. 8–10% of adult population shares risk factors with AD. Amyloid fibrils which build up in tissue as an abnormal protein form Amyloidosis. Conformational change in three-dimensional structure forms amyloid fibrils. Type 2 DM is characterized by the deposition of islet amyloid polypeptide within beta cells of the pancreas which leads to chronic cerebral hypoperfusion that result in degeneration of neuroglial cells.

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Șerdean, Călin, Alexandra Mihaela Popa, and Mario Codreanu. "Clinical-imagistic correlations in dogs with myxomatous mitral valve disease." Practica Veterinara.ro 1, no. 1 (April 19, 2018): 23–31. http://dx.doi.org/10.26416/pv.30.1.2018.1588.

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Myxomatous mitral valve disease (MMVD; degenerative valvular disease, endocardiosis, chronic valvular disease) is one of the most common acquired cardiac disease of dogs (75-80% from the cardiac diseases), characterized by mitral valve insufficiency. Pathologically, it is characterized by myxomatous degeneration of leaflets which does not have a congenital aspect, and that can progress to prolapse of one or both leaflets toward the left atrium during systole, and severe heart failure. It seems that the diseases is age and breed dependent. In most of the cases, MMVD occurs in dogs older than 5-8 years old and progresses as the dogs get older. The most predispose breed is Cavalier King Charles Spaniel, followed by Poodle (miniature and toy), Bichon, Lhassa Apso, Shih Tzu, Miniature Schnauzer, Cocker Spaniel, Chihuahua, Fox Terrier, Beagle, Pekinese, Dachshund, Yorkshire Terrier and Boston Terrier. This study aims to correlate the clinical and paraclinical examinations with the changes found in the echocardiographic examination.

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Chattopadhyay, Helen, Biswajit Auddy, Tapas Sur, Santanu Sana, and Sriparna Datta. "Accentuated transdermal application of glucosamine sulphate attenuates experimental osteoarthritis induced by monosodium iodoacetate." Journal of Materials Chemistry B 4, no. 25 (2016): 4470–81. http://dx.doi.org/10.1039/c6tb00327c.

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Nogueira, R. B., A. C. Silva, G. F. M. Reis, R. A. L. Muzzi, and M. M. Mantovani. "Muscular arterial impedance in dogs with chronic degenerative mitral valve disease." Research in Veterinary Science 93, no. 3 (December 2012): 1434–38. http://dx.doi.org/10.1016/j.rvsc.2012.07.005.

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Medina, Alejandro Marín, Eduardo Esteban Zubero, Moisés Alejandro Alatorre Jiménez, Sara Anabel Alonso Barragan, Carlos Arturo López García, José Juan Gómez Ramos, Juan Francisco Santoscoy Gutierrez, and Zurisadai González Castillo. "NOS3 Polymorphisms and Chronic Kidney Disease." Brazilian Journal of Nephrology 40, no. 3 (May 28, 2018): 273–77. http://dx.doi.org/10.1590/2175-8239-jbn-3824.

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ABSTRACT Chronic kidney disease (CKD) is a multifactorial pathophysiologic irreversible process that often leads to a terminal state in which the patient requires renal replacement therapy. Most cases of CKD are due to chronic-degenerative diseases and endothelial dysfunction is one of the factors that contribute to its pathophysiology. One of the most important mechanisms for proper functioning of the endothelium is the regulation of the synthesis of nitric oxide. This compound is synthesized by the enzyme nitric oxide synthase, which has 3 isoforms. Polymorphisms in the NOS3 gene have been implicated as factors that alter the homeostasis of this mechanism. The Glu298Asp polymorphisms 4 b/a and -786T>C of the NOS3 gene have been associated with a more rapid deterioration of kidney function in patients with CKD. These polymorphisms have been evaluated in patients with CKD of determined and undetermined etiology and related to a more rapid deterioration of kidney function.

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Ronzani, Flávio Augusto Teixeira, Filomena Maria Kirchmaier, Nathália Mussi Monteze, Edson José de Carvalho Magacho, Marcus Gomes Bastos, and Natália Maria da Silva Fernandes. "Routine mammography: an opportunity for the diagnosis of chronic degenerative diseases? A cross-sectional study." Radiologia Brasileira 50, no. 2 (March 9, 2017): 82–89. http://dx.doi.org/10.1590/0100-3984.2015.0173.

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Abstract Objective: The aim of this study was to evaluate breast arterial calcification (BAC) detected on routine mammography, analyzing its association with chronic degenerative disease. Materials and Methods: This was a cross-sectional study involving women treated at a specialized outpatient clinic for high-risk hypertension, diabetes, or chronic kidney disease, as well as volunteers who participated in a study to validate a method of screening for occult renal disease. A total of 312 patients between 40 and 69 years of age, with no history of breast cancer, all of whom had undergone routine mammography in the last two years, were included. The mammograms were analyzed by researchers who were unaware of the risk factors for BAC in each case. Results: The mean age was 55.9 ± 7.4 years, and 64.3% of the patients were white. The mean glomerular filtration rate was 41.87 ± 6.23 mL/min/1.73 m2. Seventy-one patients (22.8%) had BAC. We found that BAC was associated with advanced age, hypertension, diabetes, chronic kidney disease, and low glomerular filtration rate. In the multivariate analysis, advanced age and diabetes continued to be associated with BAC. The odds ratio for BAC was higher for all chronic diseases. Conclusion: The association of BAC with advanced age, hypertension, diabetes, chronic kidney disease, and low glomerular filtration rate should call the attention of radiologists. Therefore, the presence of BAC should be reported, and patients with BAC should be screened for those diseases.

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Al-Sawaf, Othman, Tim Clarner, Athanassios Fragoulis, Yuet Wai Kan, Thomas Pufe, Konrad Streetz, and Christoph Jan Wruck. "Nrf2 in health and disease: current and future clinical implications." Clinical Science 129, no. 12 (September 18, 2015): 989–99. http://dx.doi.org/10.1042/cs20150436.

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The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a major regulator of oxidative stress defence in the human body. As Nrf2 regulates the expression of a large battery of cytoprotective genes, it plays a crucial role in the prevention of degenerative disease in multiple organs. Thus it has been the focus of research as a pharmacological target that could be used for prevention and treatment of chronic diseases such as multiple sclerosis, chronic kidney disease or cardiovascular diseases. The present review summarizes promising findings from basic research and shows which Nrf2-targeting therapies are currently being investigated in clinical trials and which agents have already entered clinical practice.

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Kareem, Haider, and Christian Ulbricht. "A Prospective Long-term Follow-up Study of the Posterior Dynamic Stabilizing System to Treat Back Pain Associated With Degenerative Disc Disease." Global Spine Journal 10, no. 1 (May 1, 2019): 30–38. http://dx.doi.org/10.1177/2192568219844236.

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Study Design: Prospective cohort study. Objective: To evaluate the long-term effectiveness of a posterior dynamic spine stabilization (PDS) System called PercuDyn system as a treatment for low back pain (LBP) in patients with degenerative disc disease who have failed conservative treatment. Methods: Thirty-five patients (21 males, 14 females, mean age 36 years) with chronic LBP due to degenerative disc disease underwent percutaneous facet augmentation with the PercuDyn system. Indications for implanting the PercuDyn device were chronic LBP without sciatica, significant disc degeneration, and who failed conservative treatment. Follow-up after surgery ranged from 4 to 8 years. Patients were clinically evaluated using visual analogue scale (VAS), Oswestry Disability Index (ODI) questionnaire, and the EQ-5D3L. Results: The VAS scale and ODI scores improved at 6 months, 1 year, 2 years, and 4 to 8 years in comparison with the baseline values ( P < .001 and P < .01, respectively). Equally, data from the EQ-5D-3L questionnaire suggested improvements in all domains, including pain and discomfort, over the follow-up period. However, during follow-up, 16 patients (46%) have had unsatisfactory outcome including failure of implant to resolve symptoms (n = 8), developed symptomatic disc protrusion (n = 4), and loosening of the screws (n = 4). Conclusion: Our clinical experience highlights the rather high overall failure rate of this system. Although, some patients show significant improvement in their symptoms, we believe that patients with LBP related to degenerative disc disease are a poor indication for this PDS device.However, large scale studies, with optimised selection criteria are needed to demonstrate the exact role of this device in spinal patients.

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Co-Minh, Doan. "Surgical outcomes of patients with degenerative lumbar disc disease post-IntraSPINE® device fixation: Three-year prospective study." International Journal of Clinical Case Reports and Reviews 8, no. 1 (August 11, 2021): 01–10. http://dx.doi.org/10.31579/2690-4861/130.

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Background: Lumbar degenerative disc disease is one of the most common conditions associated with chronic low back pain. IntraSPINE® is a novel inter-laminar device that allows more physiological rocking-type movements in flexion and extension. Aim: To evaluate the results of patients with symptomatic Lumbar degenerative disc disease treated with an IntraSPINE® device and followed up over a 3-year period. Materials and Methods: A Prospective longitudinal research study involving patients with imaging-confirmed Lumbar degenerative disc disease in whom conservative treatment was unsuccessful. Outcome measures were changes over baseline score on the Oswestry Disability Index (ODI), and low back and radicular pain assessed at 6, 12, 24 and 36 months postoperatively. Overall success, a composite outcome that included key safety and clinical considerations, was assessed. Secondary outcomes included satisfaction with symptoms, employment status and post-surgery medical interventions. To compare differences in longitudinal clinical score patterns over 36 months, a mixed-effect model ANCOVA with repeated measurements was performed, with adjustment for low back and radicular pain score and ODI score at baseline. Results: 231 patients were recruited and 180 completed the study. A significant improvement in ODI score (p=0.0597), as well as in VAS (Visual Analogue Scale) scores for back (p= 0.0228) and leg pain (p<0.0001) was observed during the follow-up. For ODI score, the mean percentage decrease from inclusion to month 36 was 64.5%. These scores were respectively 66.2% for radicular pain and 46.4% for low back pain. In 73% of cases, surgery was considered successful. 89% of working patients returned to work and 68% of patients were very satisfied at month 12. Only four patients presented intraoperative complications.

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Koh, Keito, Keiko Yamada, Tatsuya Enomoto, Aiko Kawai, Saeko Hamaoka, Satoko Chiba, and Masako Iseki. "Sex-Specific Impact of Pain Severity, Insomnia, and Psychosocial Factors on Disability due to Spinal Degenerative Disease." Pain Research and Management 2020 (May 7, 2020): 1–6. http://dx.doi.org/10.1155/2020/8496527.

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Purpose. Pain experience due to spinal degenerative disease decreases activity of daily living and quality of life. The present cross-sectional study was aimed at examining the sex-specific impact of pain severity, psychosocial factors, and insomnia on the disability due to chronic pain arising from spinal degenerative disease. Methods. In total, 111 outpatients with chronic spinal degenerative on initial diagnosis were analyzed. The definition of chronic spinal degenerative disease was (1) pain duration ≥3 months, (2) findings of nerve root compression on neurological examination and imaging, and (3) localized neck or lower back pain (not widespread, upper or lower limb pain). We used Numerical Rating Scale (NRS), Pain Disability Assessment Scale (PDAS), Hospital Anxiety and Depression Scale (HADS), Pain Catastrophizing Scale (PCS), and Athens Insomnia Scale (AIS) to assess patients. Univariate regression analysis was performed to investigate whether sex influences the PDAS score, and sex-stratified multivariate regression analysis was conducted to identify the variables associated with the PDAS score. Results. Sex was identified as a predictor of the PDAS score (standardized coefficient (β) = 0.28; 95% confidence interval (CI), 0.10–0.46; p=0.003). In men, the AIS score was associated with PDAS (β = 0.36, 95% CI 0.09–0.63). Age (β = 0.31, 95% CI 0.06–0.55) and NRS (β = 0.40, 95% CI 0.14–0.67) were associated with PDAS in women. HADS-A, HADS-D, and PCS were not associated with PDAS in both sexes. Conclusion. Insomnia was associated with disability in men, whereas aging and pain severity were associated with disability in women. Catastrophic thinking was not associated with disability in both sexes.

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Tri Ardianto, Efri, and Alinea Dwi Elisanti. "Survival Analysis of Chronic Kidney Failure with a History of Degenerative Disease." Indian Journal of Public Health Research & Development 11, no. 1 (January 1, 2020): 1065. http://dx.doi.org/10.37506/v11/i1/2020/ijphrd/193979.

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Guglielmini, Carlo, Helen Poser, Angela Dalla Pria, Michele Drigo, Elisa Mazzotta, Michele Berlanda, and Alessia Luciani. "Red blood cell distribution width in dogs with chronic degenerative valvular disease." Journal of the American Veterinary Medical Association 243, no. 6 (September 15, 2013): 858–62. http://dx.doi.org/10.2460/javma.243.6.858.

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&NA;. "Should “Degenerative Disc Disease” Be Relabeled “Chronic Back Pain of Unknown Origin”?" Back Letter 24, no. 3 (March 2009): 28–29. http://dx.doi.org/10.1097/01.back.0000346805.29550.cb.

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Cooper, Richard S. "Control of Cardiovascular Disease in the 20th Century: Meeting the Challenge of Chronic Degenerative Disease." Perspectives in Biology and Medicine 61, no. 4 (2018): 550–59. http://dx.doi.org/10.1353/pbm.2018.0064.

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Amila, Amia, Evarina Sembiring, and Novita Aryani. "Deteksi Dini Dan Pencegahan Penyakit Degeneratif Pada Masyarakat Wilayah Mutiara Home Care." JURNAL KREATIVITAS PENGABDIAN KEPADA MASYARAKAT (PKM) 4, no. 1 (January 29, 2021): 102–12. http://dx.doi.org/10.33024/jkpm.v4i1.3441.

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ABSTRAKPenyakit degeneratif merupakan penyakit kronik menahun yang banyak mempengaruhi kualitas hidup serta produktivitas seseorang. Umumnya masyarakat baru memeriksakan diri setelah timbul gejala, padahal deteksi dini penyakit penting dilakukan. Tujuan kegiatan pengabdian kepada masyarakat ini adalah untuk upaya preventif dan meningkatkan pengetahuan tentang deteksi dini gejala, komplikasi, pencegahan, dan terapi penyakit degeneratif khususnya penyakit hipertensi, DM, aterosklerosis, osteoporosis kepada masyarakat di sekitar Klinik Mutiara Homecare Kelurahan Dwikora. Pengabdian masyarakat ini terdiri dari 2 kegiatan utama, yaitu pemeriksaan indeks massa tubuh, tekanan darah, gula darah, asam urat dan kolesterol dan pendidikan kesehatan bagi masyarakat tentang penyakit degeneratif. Hasil kegiatan didapatkan bahwa mayoritas memiliki tekanan darah sistolik <130 mmHg sebesar 60% dan tekanan darah diastolik < 90 mmHg sebesar 58%, memiliki Indeks Massa Tubuh (IMT) 25-29,9 kg/m2 (obesitas) sebesar 32%, kadar asam urat normal sebesar 66%, gula darah sewaktu < 140 mg/dL sebesar 86%, kolesterol total > 200 mg/dL sebesar 60%. Peningkatan kualitas kesehatan perlu dilakukan dengan membangun kesadaran dan peningkatan edukasi serta melakukan kontrol kesehatan secara teratur ke pusat kesehatan terdekat. Kata Kunci : Penyakit degeneratif, asam urat, gula darah, IMT, kolesterol ABSTRACTDegenerative disease is a chronic disease that affects the quality of life and productivity of a person.In general, people only have to check themselves after symptoms occur, even though early disease detection is important. The purpose of community service activites is preventive effort and increase knowledge about early detection of symptom, complication, prevention and treatment of degenerative diseases especially hypertension, DM, atherosclerosis and osteoporosis to the community around Mutiara Home Care Clinic, Dwikora Village. This community service consists of 2 main activites, namely examination of body mass index (BMI, blood pressure, blood sugar, uric acid and cholesterol and public health education about degenerative diseases. The results of this community service activites were majority had systolic blood pressure of <130 mmHg (60,0%) and diastolic blood pressure of < 90 mmHg (58%), BMI of 25-29,9 kg/m2 (obesity) as many as 32%, normal uric acid levels (66%), blood sugar at one time < 140 mg/dL (86%), total cholesterol > 200 mg/dL (60%) The increase of the quality of health needs to be done by building awareness and increased education to community and control to the nearest health center. Keywords : degenerative disease, uric acid, blood sugar levels, BMI, cholesterol

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Bragg, Robert, William Gilbert, Ahmed M. Elmansi, Carlos M. Isales, Mark W. Hamrick, William D. Hill, and Sadanand Fulzele. "Stromal cell-derived factor-1 as a potential therapeutic target for osteoarthritis and rheumatoid arthritis." Therapeutic Advances in Chronic Disease 10 (January 2019): 204062231988253. http://dx.doi.org/10.1177/2040622319882531.

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With age, joints become subject to chronic inflammatory processes that lead to degeneration of articular cartilage. Although multifactorial, cytokines have been shown to play a role in the pathogenesis of these chronic disease states. Stromal cell-derived factor 1 (SDF-1) is a chemokine that has been shown to be active in homeostatic mechanisms and developmental processes throughout the body, such as endochondral bone formation. SDF-1 plays a role in the transition from cartilage to bone. Although it has been shown to be a factor in normal development, it has also been shown to involve in the pathogenesis of rheumatoid arthritis (RA) and osteoarthritis (OA). In RA, SDF-1 has been shown to stimulate the recruitment of proinflammatory cells, as well as osteoclasts to the synovium, aiding in the facilitation of synovial degradation. Similarly, in OA, SDF-1 has been shown to regulate key proteins involved in the degradation of the cartilage of the joint. Because of its role in degenerative joint disease, SDF-1 has been investigated as a potential therapeutic target. Animal studies have been employing SDF-1 inhibitors, such as AMD3100 and T140, to study their effects on attenuating degenerative joint disease. These studies have shown promising results in slowing the progression of cartilage degradation and could potentially be used as therapeutic target for humans OA and RA.

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Jayo, M., H. W. Leipold, S. M. Dennis, and F. E. Eldridge. "Brachygnathia Superior and Degenerative Joint Disease: A New Lethal Syndrome in Angus Calves." Veterinary Pathology 24, no. 2 (March 1987): 148–55. http://dx.doi.org/10.1177/030098588702400208.

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Brachygnathia superior and generalized diarthrodial degenerative joint disease were seen in 17 related, purebred Angus calves ranging in age from 2 days to 4 months. Craniometrical studies revealed decreased maxillary and palatine bone lengths and increased cranial, skull, and facial indices. Radiological evaluation of major appendicular joints demonstrated lipping of the joint margins with osteophyte formation, sclerosis of subchondral bone, and narrowing of joint spaces. Synovial fluid evaluation indicated joint degeneration but no etiologic agent. Rheumatoid factor analysis of plasma was negative. Grossly, all major appendicular joints were defective including the atlanto-occipital articulation. Lesions ranged from loss of surface luster to erosions and deep ulcers with eburnation of the subchondral bone and secondary proliferative synovitis. Histological changes were degeneration of the articular cartilage matrix, chondrocyte necrosis, flaking and fibrillation, chondrone formation, erosions and ulcers of the articular cartilage with subchondral bone sclerosis, vascular invasion with fibrosis, and chronic, nonsuppurative, proliferative synovitis. Growth plates had defective chondrocyte proliferation and hypertrophy with aberrant ossification of calcified cartilaginous matrix. Histochemical analysis of cartilage and bone failed to incriminate which component was defective, glycosaminoglycan or collagen, but indicated different distribution or absence of one or the other. Genealogic studies revealed a genetic basis for the new defect.

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Meghil, Mohamed M., and Christopher W. Cutler. "Oral Microbes and Mucosal Dendritic Cells, “Spark and Flame” of Local and Distant Inflammatory Diseases." International Journal of Molecular Sciences 21, no. 5 (February 28, 2020): 1643. http://dx.doi.org/10.3390/ijms21051643.

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Mucosal health and disease is mediated by a complex interplay between the microbiota (“spark”) and the inflammatory response (“flame”). Pathobionts, a specific class of microbes, exemplified by the oral microbe Porphyromonas gingivalis, live mostly “under the radar” in their human hosts, in a cooperative relationship with the indigenous microbiota. Dendritic cells (DCs), mucosal immune sentinels, often remain undisturbed by such microbes and do not alert adaptive immunity to danger. At a certain tipping point of inflammation, an “awakening” of pathobionts occurs, wherein their active growth and virulence are stimulated, leading to a dysbiosis. Pathobiont becomes pathogen, and commensal becomes accessory pathogen. The local inflammatory outcome is the Th17-mediated degenerative bone disease, periodontitis (PD). In systemic circulation of PD subjects, inflammatory DCs expand, carrying an oral microbiome and promoting Treg and Th17 responses. At distant peripheral sites, comorbid diseases including atherosclerosis, Alzheimer’s disease, macular degeneration, chronic kidney disease, and others are reportedly induced. This review will review the immunobiology of DCs, examine the complex interplay of microbes and DCs in the pathogenesis of PD and its comorbid inflammatory diseases, and discuss the role of apoptosis and autophagy in this regard. Overall, the pathophysiological mechanisms of DC-mediated chronic inflammation and tissue destruction will be summarized.

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Xue, Xinghe, Yunlin Chen, Ye Wang, Jingdi Zhan, Bin Chen, Xiangyang Wang, and Xiaoyun Pan. "Troxerutin suppresses the inflammatory response in advanced glycation end-product-administered chondrocytes and attenuates mouse osteoarthritis development." Food & Function 10, no. 8 (2019): 5059–69. http://dx.doi.org/10.1039/c9fo01089k.

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Halpin, Michael. "Accounts of Suicidality in the Huntington Disease Community." OMEGA - Journal of Death and Dying 65, no. 4 (December 2012): 317–34. http://dx.doi.org/10.2190/om.65.4.e.

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Health professionals, researchers, and philosophers have debated extensively about suicide. Some believe suicides result from mental pathology, whereas others argue that individuals are capable of rational suicide. This debate is particularly poignant within illness communities, where individuals may be suffering from chronic and incurable conditions. This article engages with these issues by presenting the accounts of 20 individuals with Huntington disease (HD), a fatal degenerative condition, and 10 informal caregivers (e.g., spouses). Suicide is a leading cause of death amongst people with HD, with an incidence rate many times higher than the general population. In contrast to the majority of the academic literature on HD suicidality, study participants did not connect suicide with mental pathology. Instead, they perceived suicide as a response to the realities of living with HD, such as prolonged physiological degeneration and the need for long-term intensive health care. These findings are subsequently discussed in relation to the rational-pathological suicide binary.

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Cheng, Shih-Lung, Ching-Hsiung Lin, and Chao-Ling Yao. "Mesenchymal Stem Cell Administration in Patients with Chronic Obstructive Pulmonary Disease: State of the Science." Stem Cells International 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/8916570.

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Patients with chronic obstructive pulmonary disease (COPD) have chronic, irreversible airway inflammation; currently, there is no effective or curative treatment and the main goals of COPD management are to mitigate symptoms and improve patients’ quality of life. Stem cell based therapy offers a promising therapeutic approach that has shown potential in diverse degenerative lung diseases. Preclinical studies have demonstrated encouraging outcomes of mesenchymal stem/stromal cells (MSCs) therapy for lung disorders including emphysema, bronchopulmonary dysplasia, fibrosis, and acute respiratory distress syndrome. This review summarizes available data on 15 studies currently registered by the ClinicalTrials.gov repository, which used different stem cell therapy protocols for COPD; these included bone marrow mononuclear cells (BMMCs), bone marrow-derived MSCs, adipose-derived stem/stromal cells (ADSCs), and adipose-derived MSCs. Published results of three trials indicate that administering BMMCs or MSCs in the setting of degenerative lung disease is safe and may improve patients’ condition and quality of life; however, larger-scale studies are needed to evaluate efficacy. Results of another completed trial (NCT01872624) are not yet published, and eleven other studies are ongoing; these include MSCs therapy in emphysema, several studies of ADSCs in COPD, another in idiopathic pulmonary fibrosis, and plerixafor mobilization of CD117 stem cells to peripheral blood.

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Ma, Luyao, Zhenghai Sun, Yawen Zeng, Mingcan Luo, and Jiazhen Yang. "Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings." International Journal of Molecular Sciences 19, no. 9 (September 16, 2018): 2785. http://dx.doi.org/10.3390/ijms19092785.

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Functional ingredients in blueberry have the best health benefits. To obtain a better understanding of the health role of blueberry in chronic disease, we conducted systematic preventive strategies for functional ingredients in blueberry, based on comprehensive databases, especially PubMed, ISI Web of Science, and CNKI for the period 2008–2018. Blueberry is rich in flavonoids (mainly anthocyanidins), polyphenols (procyanidin), phenolic acids, pyruvic acid, chlorogenic acid, and others, which have anticancer, anti-obesity, prevent degenerative diseases, anti-inflammation, protective properties for vision and liver, prevent heart diseases, antidiabetes, improve brain function, protective lung properties, strong bones, enhance immunity, prevent cardiovascular diseases, and improve cognitive decline. The anthocyanins and polyphenols in blueberry are major functional ingredients for preventive chronic disease. These results support findings that blueberry may be one of the best functional fruits, and further reveals the mechanisms of anthocyanins and polyphenols in the health role of blueberry for chronic disease. This paper may be used as scientific evidence for developing functional foods, nutraceuticals, and novel drugs of blueberry for preventive chronic diseases.

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Borgarelli, M., S. Crosara, K. Lamb, P. Savarino, G. La Rosa, A. Tarducci, and J. Haggstrom. "Survival Characteristics and Prognostic Variables of Dogs with Preclinical Chronic Degenerative Mitral Valve Disease Attributable to Myxomatous Degeneration." Journal of Veterinary Internal Medicine 26, no. 1 (December 23, 2011): 69–75. http://dx.doi.org/10.1111/j.1939-1676.2011.00860.x.

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Fischer, Tamás. "The age-related macular degeneration as a vascular disease/part of systemic vasculopathy: contributions to its pathogenesis." Orvosi Hetilap 156, no. 9 (March 2015): 358–65. http://dx.doi.org/10.1556/oh.2015.30017.

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The wall of blood vessels including those in choroids may be harmed by several repeated and/or prolonged mechanical, physical, chemical, microbiological, immunologic, and genetic impacts (risk factors), which may trigger a protracted response, the so-called host defense response. As a consequence, pathological changes resulting in vascular injury (e. g. atherosclerosis, age-related macular degeneration) may be evolved. Risk factors can also act directly on the endothelium through an increased production of reactive oxygen species promoting an endothelial activation, which leads to endothelial dysfunction, the onset of vascular disease. Thus, endothelial dysfunction is a link between the harmful stimulus and vascular injury; any kind of harmful stimuli may trigger the defensive chain that results in inflammation that may lead to vascular injury. It has been shown that even early age-related macular degeneration is associated with the presence of diffuse arterial disease and patients with early age-related macular degeneration demonstrate signs of systemic and retinal vascular alterations. Chronic inflammation, a feature of AMD, is tightly linked to diseases associated with ED: AMD is accompanied by a general inflammatory response, in the form of complement system activation, similar to that observed in degenerative vascular diseases such as atherosclerosis. All these facts indicate that age-related macular degeneration may be a vascular disease (or part of a systemic vasculopathy). This recognition could have therapeutic implications because restoration of endothelial dysfunction may prevent the development or improve vascular disease resulting in prevention or improvement of age-related macular degeneration as well. Orv. Hetil., 2015, 156(9), 358–365.

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Rezuș, Elena, Anca Cardoneanu, Alexandra Burlui, Andrei Luca, Cătălin Codreanu, Bogdan Tamba, Gabriela-Dumitrița Stanciu, Nicoleta Dima, Codruța Bădescu, and Ciprian Rezuș. "The Link Between Inflammaging and Degenerative Joint Diseases." International Journal of Molecular Sciences 20, no. 3 (January 31, 2019): 614. http://dx.doi.org/10.3390/ijms20030614.

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Aging is an inevitable process in the human body that is associated with a multitude of systemic and localized changes. All these conditions have a common pathogenic mechanism characterized by the presence of a low-grade proinflammatory status. Inflammaging refers to all the processes that contribute to the occurrence of various diseases associated with aging such as frailty, atherosclerosis, Alzheimer’s disease, sarcopenia, type 2 diabetes, or osteoarthritis. Inflammaging is systemic, chronic, and asymptomatic. Osteoarthritis and many age-related degenerative joint diseases are correlated with aging mechanisms such as the presence of an inflammatory microenvironment and the impaired link between inflammasomes and autophagy. There is a close relationship between chondrocyte activity and local articular environment changes due to cell senescence, followed by secretion of inflammatory mediators. In addition, systemic inflammaging can lead to cartilage destruction, pain, disability, and an impaired quality of life. The purpose of this review is to summarize the main mechanisms implicated in inflammaging and the connection it has with degenerative joint diseases.

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Ayre, S. G., D. Perez Garcia y Bellon, and D. Perez Garcia. "Insulin potentiation therapy: A new concept in the management of chronic degenerative disease." Medical Hypotheses 20, no. 2 (June 1986): 199–210. http://dx.doi.org/10.1016/0306-9877(86)90126-x.

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Trinh, Kien, Xuejun Cui, and Yong-Jun Wang. "Chinese Herbal Medicine for Chronic Neck Pain due to Cervical Degenerative Disc Disease." Spine 35, no. 24 (November 2010): 2121–27. http://dx.doi.org/10.1097/brs.0b013e3181edfd17.

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Phillips, Frank M., Paul J. Slosar, Jim A. Youssef, Gunnar Andersson, and Frank Papatheofanis. "Lumbar Spine Fusion for Chronic Low Back Pain Due to Degenerative Disc Disease." Spine 38, no. 7 (April 2013): E409—E422. http://dx.doi.org/10.1097/brs.0b013e3182877f11.

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Journal articles on the topic 'Chronic degenerative disease'

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