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Journal articles on the topic 'Chronic hyperglycemia'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Strycharz, Justyna, Ewa Świderska, Adam Wróblewski, et al. "Hyperglycemia Affects miRNAs Expression Pattern during Adipogenesis of Human Visceral Adipocytes—Is Memorization Involved?" Nutrients 10, no. 11 (2018): 1774. http://dx.doi.org/10.3390/nu10111774.

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microRNAs are increasingly analyzed in adipogenesis, whose deregulation, especially visceral, contributes to the development of diabetes. Hyperglycemia is known to affect cells while occurring acutely and chronically. Therefore, we aimed to evaluate the effect of hyperglycemia on human visceral pre/adipocytes from the perspective of microRNAs. The relative expression of 78 microRNAs was determined by TaqMan Low Density Arrays at three stages of HPA-v adipogenesis conducted under normoglycemia, chronic, and intermittent hyperglycemia (30 mM). Hierarchical clustering/Pearson correlation revealed

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Bishara, Amy, Stephanie V. Phan, Henry N. Young, and T. Vivian Liao. "Glucose Disturbances and Atypical Antipsychotic Use in the Intensive Care Unit." Journal of Pharmacy Practice 29, no. 6 (2016): 534–38. http://dx.doi.org/10.1177/0897190015579452.

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Purpose: Chronic use of atypical antipsychotics may lead to metabolic abnormalities including hyperglycemia. Although evidence supports acute hyperglycemic episodes associated with atypical antipsychotic use, the acute use of atypical antipsychotics in the intensive care unit (ICU) setting has not been studied. The purpose of this study is to evaluate the occurrence of hyperglycemia in ICU patients receiving newly prescribed atypical antipsychotic. Summary: Of the 273 patient charts reviewed, 50 patients were included in this study. Approximately 45% of patients experienced at least 1 hypergly

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3

Luitse, Merel JA, Birgitta K. Velthuis, L. Jaap Kappelle, Yolanda van der Graaf, and Geert Jan Biessels. "Chronic hyperglycemia is related to poor functional outcome after acute ischemic stroke." International Journal of Stroke 12, no. 2 (2016): 180–86. http://dx.doi.org/10.1177/1747493016676619.

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Background Acute hyperglycemia is associated with poor functional outcome after ischemic stroke, but the association between chronic antecedent hyperglycemia and outcome is unclear. Aim We assessed the association between chronic hyperglycemia, measured by hemoglobin A1c, and functional outcome in patients with acute ischemic stroke. Methods We included 812 patients with acute ischemic stroke (mean age 66 ± 14 years; 61.5% male). Patients were categorized per hemoglobin A1c level: no (<39 mmol/mol), moderate (39–42 mmol/mol), or severe chronic hyperglycemia (>42 mmol/mol). Poor functiona

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Lund, Jenny, D. Margriet Ouwens, Marianne Wettergreen, Siril S. Bakke, G. Hege Thoresen, and Vigdis Aas. "Increased Glycolysis and Higher Lactate Production in Hyperglycemic Myotubes." Cells 8, no. 9 (2019): 1101. http://dx.doi.org/10.3390/cells8091101.

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Previous studies have shown that chronic hyperglycemia impairs glucose and fatty acid oxidation in cultured human myotubes. To further study the hyperglycemia-induced suppression of oxidation, lactate oxidation, mitochondrial function and glycolytic rate were evaluated. Further, we examined the intracellular content of reactive oxygen species (ROS), production of lactate and conducted pathway-ANOVA analysis on microarray data. In addition, the roles of the pentose phosphate pathway (PPP) and the hexosamine pathway were evaluated. Lactic acid oxidation was suppressed in hyperglycemic versus nor

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Świderska, Ewa, Marta Podolska, Justyna Strycharz та ін. "Hyperglycemia Changes Expression of Key Adipogenesis Markers (C/EBPα and PPARᵞ)and Morphology of Differentiating Human Visceral Adipocytes". Nutrients 11, № 8 (2019): 1835. http://dx.doi.org/10.3390/nu11081835.

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Disturbances in adipose tissue significantly contribute to the development of metabolic disorders, which are connected with hyperglycemia (HG) and underlain by epigenetics-based mechanisms. Therefore, we aimed to evaluate the effect of hyperglycemia on proliferating, differentiating and maturating human visceral pre/adipocytes (HPA-v). Three stages of cell culture were conducted under constant or variable glycemic conditions. Adipogenesis progress was assessed using BODIPY 505/515 staining. Lipid content typical for normal and hyperglycemic conditions of adipocytes was analyzed using Raman spe

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Frost, Mackenzie S., Aqib H. Zehri, Sean W. Limesand, William W. Hay та Paul J. Rozance. "Differential Effects of Chronic Pulsatile versus Chronic Constant Maternal Hyperglycemia on Fetal Pancreaticβ-Cells". Journal of Pregnancy 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/812094.

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Constant maternal hyperglycemia limits, while pulsatile maternal hyperglycemia may enhance, fetal glucose-stimulated insulin secretion (GSIS) in sheep. However, the impact of such different patterns of hyperglycemia on the development of the fetalβ-cell is unknown. We measured the impact of one week of chronic constant hyperglycemia (CHG,n=6) versus pulsatile hyperglycemia (PHG,n=5) versus controls (n=7) on the percentage of the fetal pancreas staining for insulin (β-cell area), mitotic and apoptotic indices and size of fetalβ-cells, and fetal insulin secretion in sheep. Baseline insulin conce

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de Mello-Sampayo, Cristina, Alaíde Alves Agripino, Duarte Stilwell, et al. "Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures." International Journal of Endocrinology 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/4603247.

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There is controversy concerning the diabetes impact on bone quality, notorious in type 2 diabetic postmenopausal women. One pointed cause might be uncontrolled glycemia. In this study, the effect of chronic hyperglycemia in bone turnover, morphology, and biomechanics was evaluated in female Wistar rats in the presence/absence of estrogens (ovariectomy). Animals (n=28) were divided into sham, ovariectomized (OVX), hyperglycemic (streptozotocin 40 mg/kg, single-dose i.p.-STZ), and hyperglycemic-ovariectomized (STZ + OVX) animals. Blood biomarkers were estimated 60 days postovariectomy. Body weig

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Khan, Shahzad, and Mohammad A. Kamal. "Wogonin Alleviates Hyperglycemia Through Increased Glucose Entry into Cells Via AKT/GLUT4 Pathway." Current Pharmaceutical Design 25, no. 23 (2019): 2602–6. http://dx.doi.org/10.2174/1381612825666190722115410.

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: Insulin resistance and type 2 Diabetes mellitus resulting in chronic hyperglycemia is a major health problem in the modern world. Many drugs have been tested to control hyperglycemia which is believed to be the main factor behind many of the diabetes-related late-term complications. Wogonin is a famous herbal medicine which has been shown to be effective in controlling diabetes and its complications. In our previous work, we showed that wogonin is beneficial in many ways in controlling diabetic cardiomyopathy. In this review, we mainly explained wogonin anti-hyperglycemic property through AK

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9

Marcovecchio, M. Loredana. "Complications of Acute and Chronic Hyperglycemia." US Endocrinology 13, no. 01 (2017): 17. http://dx.doi.org/10.17925/use.2017.13.01.17.

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Hyperglycemia is due to a dysregulation in the complex mechanisms implicated in glucose homeostasis. Chronic hyperglycemia, as measured by hemoglobin A1c (HbA1c), is a key risk factor for the development of microvascular and macrovascular complications, which in turn negatively influence the prognosis of patients with diabetes. Several studies have shown that acute hyperglycemia can add to the effect of chronic hyperglycemia in inducing tissue damage. Acute hyperglycemia can manifest as high fasting plasma glucose (FPG) or high postprandial plasma glucose (PPG) and can activate the same metabo

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10

Clark, C. M. "The Burden of Chronic Hyperglycemia." Diabetes Care 21, Supplement_3 (1998): C32—c34. http://dx.doi.org/10.2337/diacare.21.3.c32.

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11

Chang, Shu-Chun, and Wei-Chung Vivian Yang. "Hyperglycemia, tumorigenesis, and chronic inflammation." Critical Reviews in Oncology/Hematology 108 (December 2016): 146–53. http://dx.doi.org/10.1016/j.critrevonc.2016.11.003.

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12

Abad-González, Ángel Luis, Silvia Veses, María Argente Pla, et al. "Medical Nutrition Therapy and Physical Exercise for Acute and Chronic Hyperglycemic Patients with Sarcopenia." Nutrients 17, no. 3 (2025): 499. https://doi.org/10.3390/nu17030499.

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A wide range of factors contribute to the overlap of hyperglycemia—acute or chronic—and sarcopenia, as well as their associated adverse consequences, which can lead to impaired physical function, reduced quality of life, and increased mortality risk. These factors include malnutrition (both overnutrition and undernutrition) and low levels of physical activity. Hyperglycemia and sarcopenia are interconnected through a vicious cycle of events that mutually reinforce and worsen each other. To explore this association, our review compiles evidence on: (i) the impact of hyperglycemia on motor and m

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13

Mosili, Palesa, Bongeka Cassandra Mkhize, Ntethelelo Hopewell Sibiya, Phikelelani Sethu Ngubane, and Andile Khathi. "Review of the direct and indirect effects of hyperglycemia on the HPA axis in T2DM and the co-occurrence of depression." BMJ Open Diabetes Research & Care 12, no. 1 (2024): e003218. http://dx.doi.org/10.1136/bmjdrc-2022-003218.

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Type 2 diabetes mellitus (T2DM) is characterized by persistent hyperglycemia which is further associated with hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. Several studies have shown that HPA axis hyperactivity is heightened in the chronic hyperglycemic state with severe hyperglycemic events more likely to result in a depressive disorder. The HPA axis is also regulated by the immune system. Upon stress, under homeostatic conditions, the immune system is activated via the sympatho-adrenal-medullary axis resulting in an immune response which secretes proinflammatory cytokines.

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14

Bhattarai, Govinda, Han-Sol So, Thi Thu Trang Kieu, Sung-Ho Kook, Jeong-Chae Lee, and Young-Mi Jeon. "Astaxanthin Inhibits Diabetes-Triggered Periodontal Destruction, Ameliorates Oxidative Complications in STZ-Injected Mice, and Recovers Nrf2-Dependent Antioxidant System." Nutrients 13, no. 10 (2021): 3575. http://dx.doi.org/10.3390/nu13103575.

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Numerous studies highlight that astaxanthin (ASTX) ameliorates hyperglycemic condition and hyperglycemia-associated chronic complications. While periodontitis and periodontic tissue degradation are also triggered under chronic hyperglycemia, the roles of ASTX on diabetes-associated periodontal destruction and the related mechanisms therein are not yet fully understood. Here, we explored the impacts of supplemental ASTX on periodontal destruction and systemic complications in type I diabetic mice. To induce diabetes, C57BL/6 mice received a single intraperitoneal injection of streptozotocin (ST

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15

Quader, Mohammad Rezaul, Mohammad Jahidur Rahman Khan, Arifa Akram, et al. "COVID-19 and Diabetes: Acknowledging the Bidirectional Link." Bangabandhu Sheikh Mujib Medical College Journal 1, no. 2 (2023): 99–103. http://dx.doi.org/10.3329/bsmmcj.v1i2.69349.

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COVID-19 and diabetes mellitus have a dynamic and bidirectional relationship. Diabetes is a risk factor for COVID19. Diabetes mellitus is linked to hypercoagulability, inflammation, hyperglycemia, and other conditions (obesity, hypertension, cardiovascular disease, chronic kidney disease). Hyperglycemia may worsen SARS-CoV-2 infection. As a result of direct pancreatic damage caused by COVID-19, the stress response is triggered response to infection (including cytokine storm), including the use of hyperglycemic prescription medications such as corticosteroids for severe COVID-19, new-onset hype

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Carnovali, Marta, Livio Luzi, Ileana Terruzzi, Giuseppe Banfi, and Massimo Mariotti. "Liquiritigenin Reduces Blood Glucose Level and Bone Adverse Effects in Hyperglycemic Adult Zebrafish." Nutrients 11, no. 5 (2019): 1042. http://dx.doi.org/10.3390/nu11051042.

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Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia that induces other pathologies including diabetic retinopathy and bone disease. Adult Danio rerio (zebrafish) represents a powerful model to study both glucose and bone metabolism. Then, the aim of this study was to evaluate the effects of liquiritigenin (LTG) on blood glucose level and diabetes complications in hyperglycemic adult zebrafish. LTG is a flavonoid extracted from Glycyrrhiza glabra roots which possess important antioxidant, anti-inflammatory, and anti-diabetic properties. During four weeks of glucose t

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Jayasuriya, Ravichandran, Kumar Ganesan, and Kunka Mohanram Ramkumar. "Mangiferin Represses Inflammation in Macrophages under a Hyperglycemic Environment through Nrf2 Signaling." International Journal of Molecular Sciences 25, no. 20 (2024): 11197. http://dx.doi.org/10.3390/ijms252011197.

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Inflammation in macrophages is exacerbated under hyperglycemic conditions, contributing to chronic inflammation and impaired wound healing in diabetes. This study investigates the potential of mangiferin, a natural polyphenol, to alleviate this inflammatory response by targeting a redox-sensitive transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2). Mangiferin, a known Nrf2 activator, was evaluated for its ability to counteract the hyperglycemia-induced inhibition of Nrf2 and enhance antioxidant defenses. The protective effects of mangiferin on macrophages in a hyperglycemi

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18

Poonoosamy, Juliana, Philippe Lopes, Priscille Huret, et al. "Impact of Intensive Glycemic Treatment on Diabetes Complications—A Systematic Review." Pharmaceutics 15, no. 7 (2023): 1791. http://dx.doi.org/10.3390/pharmaceutics15071791.

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Diabetes complications can be related to the long duration of the disease or chronic hyperglycemia. The follow-up of diabetic patients is based on the control of chronic hyperglycemia, although this correction, if obtained rapidly in people living with severe chronic hyperglycemia, can paradoxically interfere with the disease or even induce complications. We reviewed the literature describing the impact of the rapid and intense treatment of hyperglycemia on diabetic complications. The literature review showed that worsening complications occurred significantly in diabetic microangiopathy with

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Maksymova, Olena S., Svitlana M. German, Pavlo O. Moskalenko, et al. "FEATURES OF SKIN WOUNDS HEALING UNDER CHRONIC HYPERGLYCEMIA AND IMPROVEMENT OF THEIR TREATMENT METHODS." Wiadomości Lekarskie 74, no. 5 (2021): 1174–79. http://dx.doi.org/10.36740/wlek202105124.

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The aim: The work was aimed to study the histological, morphometric and planimetric features of skin regeneration in mature rats with chronic hyperglycemia under the influence of platelet-rich plasma. Materials and methods: 60 mature white laboratory rats were used. The animals were divided into three groups (I – control with mechanical skin injuries; II – rats with chronic hyperglycemia and modeled mechanical skin injuries; III – animals with the chronic hyperglycemia and modeled mechanical skin injuries which were injected with the platelet-rich plasma). The samples were studied using light

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20

Carlsson, Per-Ola, Arne Andersson, and Leif Jansson. "Influence of age, hyperglycemia, leptin, and NPY on islet blood flow in obese-hyperglycemic mice." American Journal of Physiology-Endocrinology and Metabolism 275, no. 4 (1998): E594—E601. http://dx.doi.org/10.1152/ajpendo.1998.275.4.e594.

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This study aimed to elucidate possible age-related changes in islet blood perfusion in lean and obese C57BL/6 mice. Obese mice aged 1 mo were hyperglycemic and hyperinsulinemic and had an increased islet blood flow compared with age-matched lean mice. This augmented blood flow could be abolished by pretreatment with leptin. The islet blood perfusion was, in contrast to this, markedly decreased in obese 6- to 7-mo-old animals compared with age-matched lean mice. Reversal of hyperglycemia, but not hyperinsulinemia, in these obese mice with phlorizin normalized the islet blood flow. Spontaneous r

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Rubin, Jonathan, Kunihiro Matsushita, Christie M. Ballantyne, Ron Hoogeveen, Josef Coresh, and Elizabeth Selvin. "Chronic Hyperglycemia and Subclinical Myocardial Injury." Journal of the American College of Cardiology 59, no. 5 (2012): 484–89. http://dx.doi.org/10.1016/j.jacc.2011.10.875.

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22

Micky, Kumari1, Beura2 Rajdeep, and Purkayastha3 Adrita. "Associative Link Between Chronic Periodontitis & Hyperglycemia." Heal Talk - A Journal of Clinical Dentitsry 16, no. 04 (2024): 2. https://doi.org/10.5281/zenodo.11000724.

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Periodontitis is an immune-inflammatory diseases of the periodontal tissue chara-cterized by destruction of bone and connective tissue attachment (Tho-mas et al. 2013)     Several experimental and human studies have shown that infections are accompanied by a decrease in glucose tolerance and hyperinsulinemia, which together indicate the presence of insulin resistance. (K. Sammalkorpi, 1989)     Periodontal infection is associated with hyperglycemia and diabetes (Demmer et al., 2012; Borgnakke et al.,2013) 

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Gordon, Erin E., Benjamin E. Reinking, Shanming Hu, et al. "Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats." Journal of Diabetes Research 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/479565.

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Cardiac septal overgrowth complicates 10–40% of births from diabetic mothers, but perplexingly hyperglycemia markers during pregnancy are not reliably predictive. We thus tested whether fetal exposure to hyperglycemia is sufficient to induce fetal cardiac septal overgrowth even in the absence of systemic maternal diabetes. To isolate the effects of hyperglycemia, we infused glucose into the blood supply of the left but not right uterine horn in nondiabetic pregnant rats starting on gestational day 19. After 24 h infusion, right-sided fetuses and dams remained euglycemic while left-sided fetuse

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Rajapakse, Angana Gupta, Xiu-Fen Ming, João M. Carvas та Zhihong Yang. "O-linked β-N-acetylglucosamine During Hyperglycemia Exerts Both Anti-Inflammatory and Pro-Oxidative Properties in the Endothelial System". Oxidative Medicine and Cellular Longevity 2, № 3 (2009): 172–75. http://dx.doi.org/10.4161/oxim.2.3.8482.

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Elevated cellular levels of proteinO-linked β-N-acetylglucosamine (O-GlcNAc) through hexosamine biosynthesis pathway (HBP) are suggested to contribute to cardiovascular adverse effects under chronic hyperglycemic condition associated with oxidative stress and inflammation. Conversely, enhancingO-GlcNAc levels have also been demonstrated being protective against myocardial ischemia/reperfusion injury. We recently demonstrated that hyperglycemia increases oxidative stress and HBP flux in endothelial cells and enhances endothelial expression of vascular adhesion molecule-1 (VCAM-1) and intercellu

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Fernandes, Sheila Marques, Daniel Malisani Martins, Cassiane Dezoti da Fonseca, Mirian Watanabe, and Maria de Fátima Fernandes Vattimo. "Impact of Iodinated Contrast on Renal Function and Hemodynamics in Rats with Chronic Hyperglycemia and Chronic Kidney Disease." BioMed Research International 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/3019410.

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Iodinated contrast (IC) is clinically used in diagnostic and interventional procedures, but its use can result in contrast-induced acute kidney injury (CI-AKI). Chronic kidney disease (CKD) and chronic hyperglycemia (CH) are important predisposing factors to CI-AKI. The aim of this study was to investigate the impact of iodinated contrast on the renal function and hemodynamics in rats with chronic hyperglycemia and chronic kidney disease. A total of 30 rats were divided into six groups; Sham: control of chronic renal disease; Citrate: control of chronic hyperglycemia (CH); Nx5/6: rats with 5/6

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Lee, S. H., C. H. Kao, and V. C. Yang. "Distribution of Low-Density Lipoprotein in the Aortic Intima of Hyperglycemic Rats." Microscopy and Microanalysis 7, S2 (2001): 646–47. http://dx.doi.org/10.1017/s1431927600029305.

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Chronic hyperglycemia is a common feature of all forms of diabetes mellitus and may contribute greatly to the increase in the incidence of atherosclerosis. It has been demonstrated that increasing arterial permeability to the macromolecules can cause low-density lipoproteins (LDLs) to infiltrate and accumulate in the intima. This event is crucial for developing the plaques in the arterial wall. in this study, we use Evans blue to study the permeability of arterial endothelium in the streptozotocin (STZ)-induced hyperglycemic rats. We also use colloidal gold-labeled LDL to investigate in situ t

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Tri Setyawati, Sarniwaty Kamissy, and Wisnu Pradhana Merta. "Diabetic Ketoacidosis in Type 2 Diabetes Mellitus Patients with a History of Hypertension: Case Report." International Journal of Health, Economics, and Social Sciences (IJHESS) 5, no. 3 (2023): 261–64. http://dx.doi.org/10.56338/ijhess.v5i3.3674.

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Diabetes Mellitus Type 2 is a chronic hyperglycemic disease due to insensitivity of cells to insulin. High glucose levels can cause metabolic problems that occur due to abnormalities in insulin secretion resulting in symptoms of decreased consciousness, a condition known as diabetic ketoacidosis. One of the complications of diabetes is stroke caused by hypertension. This report describes a 69-year-old male patient who was diagnosed with type 2 diabetes mellitus with a history of hypertension who had decreased consciousness. Type 2 Diabetes Mellitus is a hyperglycemic disease due to insensitivi

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Mussi, Natalia, Whitney L. Stuard, Jose Marcos Sanches, and Danielle M. Robertson. "Chronic Hyperglycemia Compromises Mitochondrial Function in Corneal Epithelial Cells: Implications for the Diabetic Cornea." Cells 11, no. 16 (2022): 2567. http://dx.doi.org/10.3390/cells11162567.

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Mitochondrial dysfunction is a major pathophysiological event leading to the onset of diabetic complications. This study investigated the temporal effects of hyperglycemia on mitochondrial metabolism in corneal epithelial cells. To accomplish this, human telomerase-immortalized corneal epithelial cells were cultured in a defined growth medium containing 6 mM glucose. To simulate hyperglycemia, cells were cultured in a medium containing 25 mM D-glucose, and control cells were cultured in mannitol. Using metabolic flux analysis, there was a hyperosmolar-mediated increase in mitochondrial respira

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Espinoza-Hernández, Fernanda A., and Adolfo Andrade-Cetto. "Chronic Antihyperglycemic Effect Exerted by Traditional Extracts of Three Mexican Medicinal Plants." Evidence-Based Complementary and Alternative Medicine 2022 (November 9, 2022): 1–9. http://dx.doi.org/10.1155/2022/5970358.

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Chronic hyperglycemia, the product of uncontrolled diabetes, leads to the appearance of vascular complications that can result in the premature death of diabetic patients. Consequently, pharmacological intervention with hypoglycemic agents could delay these complications and improve the quality of life of patients in the long term. Traditional Mexican medicine provides a great wealth of medicinal plants that are used for the treatment of type 2 diabetes, the most prevalent form of diabetes, accounting for nearly 90–95% of total cases. However, there is still a lack of studies that support thei

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Mullan, Brian A., Ciaran N. Ennis, Howard J. P. Fee, Ian S. Young, and David R. McCance. "Protective effects of ascorbic acid on arterial hemodynamics during acute hyperglycemia." American Journal of Physiology-Heart and Circulatory Physiology 287, no. 3 (2004): H1262—H1268. http://dx.doi.org/10.1152/ajpheart.00153.2003.

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Mortality increases when acute coronary syndromes are complicated by stress-induced hyperglycemia. Early pulse wave reflection can augment central aortic systolic blood pressure and increase left ventricular strain. Altered pulse wave reflection may contribute to the increase in cardiac risk during acute hyperglycemia. Chronic ascorbic acid (AA) supplementation has recently been shown to reduce pulse wave reflection in diabetes. We investigated the in vivo effects of acute hyperglycemia, with and without AA pretreatment, on pulse wave reflection and arterial hemodynamics. Healthy male voluntee

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Kurniawan, Shahdevi Nandar, Muthia Marwah, Rodhiyan R, and Nanik S. "THE EFFECT OF 500 NM DOSAGE OF NIMODIPINE ON NRF2 AND NF-KB EXPRESSION IN NEURON CELL LINE CULTURE SH-SY5Y EXPOSED WITH CHRONIC HYPERGLYCEMIA." International Journal of Research -GRANTHAALAYAH 8, no. 2 (2020): 235–42. http://dx.doi.org/10.29121/granthaalayah.v8.i2.2020.214.

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Introduction: Metabolic stress and mitochondrial dysfunction in chronic hyperglycemia can cause an increase in Ca2+ cytosol ions that cause dysfunction of NRF2, that will increase the activity of NF-kB which causes an increase in cytokine production, where NF-kB can modulate NRF2 transcription and its activity, so that it has positive or negative effects in the target gene. Giving nimodipine in chronic hyperglycemia conditions can increase levels of NRF2 molecules and reduce levels of NF-kB. Aim: The purpose of this research is to know the effect of treating nimodipine dose 5 μM towards expres

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Shahdevi, Nandar Kurniawan, Marwah Muthia, R. Rodhiyan, and S. Nanik. "THE EFFECT OF 500 NM DOSAGE OF NIMODIPINE ON NRF2 AND NFKB EXPRESSION IN NEURON CELL LINE CULTURE SH-SY5Y EXPOSED WITH CHRONIC HYPERGLYCEMIA." International Journal of Research - Granthaalayah 8, no. 2 (2020): 235–42. https://doi.org/10.5281/zenodo.3709190.

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Introduction: Metabolic stress and mitochondrial dysfunction in chronic hyperglycemia can cause an increase in Ca2+ cytosol ions that cause dysfunction of NRF2, that will increase the activity of NF-kB which causes an increase in cytokine production, where NF-kB can modulate NRF2 transcription and its activity, so that it has positive or negative effects in the target gene. Giving nimodipine in chronic hyperglycemia conditions can increase levels of NRF2 molecules and reduce levels of NF-kB. Aim: The purpose of this research is to know the effect of treating nimodipine dose 5 μM towards exp

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Maksymova, O. S. "Healing of Skin Wounds of Old Rats in Conditions of Chronic Hyperglycemia Using Platelet-Rich Plasma." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 2 (2021): 44–50. http://dx.doi.org/10.26693/jmbs06.02.044.

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Wound regeneration is a complex problem for modern healthcare, since the existing methods of treatment are not always effective, which necessitates the development of new promising methods. In this regard, today researchers are greatly interested in the possibility of using platelet-rich plasma in the treatment of patients with soft tissue injuries. The purpose of our research was to study the micro-, ultrastructural, planimetric and morphometric features of the skin reparative regeneration of old rats under the chronic hyperglycemia using platelet-rich plasma. Material and methods. The study

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Maharani, Arief Sjamsulaksan Kartasasmita, Fifin Luthfia Rahmi, et al. "Exploring the impact of oxidative stress, excitotoxicity, and apoptosis of retinal ganglion cells in streptozotocin-induced rats: A comprehensive investigation." Journal of Advanced Pharmaceutical Technology & Research 15, no. 4 (2024): 304–8. http://dx.doi.org/10.4103/japtr.japtr_177_24.

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Chronic hyperglycemia activates pathological molecular pathways, causing high inflammatory mediators, oxidative stress, and growth factors. This process contributes to retinal ganglion cell (RGC) apoptosis through the expression of N-methyl-D-aspartate (NMDA) receptors and nitric oxide (NO). This study analyzes the differential effect of NMDA receptor, NO expression, and RGC apoptosis in a hyperglycemic Wistar rat model. This research was designed as an experimental study, using a posttest only control group method. Fourteen male Wistar rats were split into two groups of seven: One received a

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Egyed-Kolumbán, Abigél, Benita Onhausz, Bence Pál Barta, et al. "Insulin in Myenteric Neurons: Time-Dependent and Regional Changes in Type 1 Diabetic Rats." Cells 14, no. 11 (2025): 809. https://doi.org/10.3390/cells14110809.

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Enteric neurons regulating motility display regional damage to diabetes. By inhibiting neuroinflammation, insulin can contribute to neuronal survival, therefore, we aimed to investigate the presence of insulin in myenteric neurons and their nitrergic population in acute and chronic rat models of type 1 diabetes. One or ten weeks after the onset of hyperglycemia, gut segments and the pancreas of control, diabetic, and insulin-treated diabetic rats were investigated. In the controls, insulin-immunoreactive neurons comprised 8–9% of the total myenteric neuronal population in the ileum and colon a

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Hujoel, P. P., and M. Stott-Miller. "Retinal and Gingival Hemorrhaging and Chronic Hyperglycemia." Diabetes Care 34, no. 1 (2010): 181–83. http://dx.doi.org/10.2337/dc10-0901.

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Chen, Congde, Suichun Wu, Zipu Hong, et al. "Chronic hyperglycemia regulates microglia polarization through ERK5." Aging 11, no. 2 (2019): 697–706. http://dx.doi.org/10.18632/aging.101770.

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Anfossi, Giovanni, Isabella Russo, Katia Bonomo, and Mariella Trovati. "The Old and the New in the Treatment of Type 2 Diabetes: Focus on the Combination Therapy with Dipeptidyl Peptidase-4 Inhibitors and Metformin." Clinical Medicine Insights: Therapeutics 2 (January 2010): CMT.S3420. http://dx.doi.org/10.4137/cmt.s3420.

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Type 2 diabetes mellitus (T2DM) is a complex multifactorial disease which affects the length and quality of life by severe chronic complications. Chronic hyperglycemia, which is the main alteration in T2DM, is strictly related to microvascular complications (such as retinopathy and nephropathy) and neuropathy, whereas large vessel atherosclerosis is also dependent on lipid and hemostasis abnormalities, arterial hypertension and other known cardiovascular risk factors. An early intervention to control hyperglycemia and to prevent deterioration of β-cell function is considered mandatory in patie

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Panchagnula, Neha, and William Philip Brasher. "Hyperglycemia and Venous Thromboembolism." Diagnostics 14, no. 17 (2024): 1994. http://dx.doi.org/10.3390/diagnostics14171994.

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Patients with diabetes mellitus (DM) have chronically increased blood glucose and multiple physiologic alterations that place them at elevated risk for vascular disease. Traditionally, this vascular risk has mainly referred to chronic atherosclerosis and embolic arterial disease. Retrospective studies have suggested an increased risk of a pulmonary embolism (PE) and deep vein thrombosis (DVT), collectively termed venous thromboembolism (VTE), in patients with DM, but this association has been difficult to demonstrate with comorbidities such as obesity in meta-analysis. Clinical studies have de

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Dardari, Dured, and Beatrice Segurence. "Rapid correction of chronic hyperglycemia and bone remodeling, warning against overdoing." World Journal of Diabetes 15, no. 9 (2024): 1858–61. http://dx.doi.org/10.4239/wjd.v15.i9.1858.

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It is widely recognized that chronic hyperglycemia decreases bone quality, although little is known about the impact of the rapid correction of chronic hyperglycemia on the quality of bone remodeling. This spotlight article explores this correlation by focusing on the stages of bone remodeling linked to glucose levels.

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Ilyas, Syafruddin, Salomo Hutahaean, Rahmat S. H. Sinaga, and Putri C. Situmorang. "Effect of sikkam (Bischofia javanica Blume) ethanolic extract on the quality and quantity of hyperglycemic rat sperm." Journal of Pharmacy & Pharmacognosy Research 10, no. 2 (2022): 270–78. http://dx.doi.org/10.56499/jppres21.1204_10.2.270.

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Context: Hyperglycemia causes diabetes mellitus (DM), abnormal metabolism, oxidative stress, and chronic complications such as impotence. Hyperglycemia causes testicular atrophy and stromal cell, seminiferous tubular damage, and spermatogenic cells. Bischofia javanica Blume is a plant that is used for the treatment of various chronic conditions and has traditionally by the people of Indonesia as a diabetes medicine. Aims: To determine the effect of B. javanica extract on the increase in the quality and quantity of sperm of hyperglycemic rats. Methods: The treatment groups consisted of; G0: neg

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Hu, Xuan, Xueming Liu, Yujiao Guo, et al. "Effects of Chicken Serum Metabolite Treatment on the Blood Glucose Control and Inflammatory Response in Streptozotocin-Induced Type 2 Diabetes Mellitus Rats." International Journal of Molecular Sciences 24, no. 1 (2022): 523. http://dx.doi.org/10.3390/ijms24010523.

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Chickens can live healthy without adverse effects despite high blood glucose levels. However, the blood biomolecules responsible for maintaining chronic hyperglycemia are unknown. Here, the effects of chicken serum metabolite treatment on blood glucose control and inflammatory response in streptozotocin (STZ)-induced Type 2 Diabetes Mellitus (T2DM) rats were investigated. First, chicken serum treatment reduced the advanced glycation end-products (AGEs) and blood glucose levels in STZ-induced T2DM rats. Second, insulin/glucose-induced acute hypoglycemic/hyperglycemic chickens and the blood biom

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Higginson, Ray, Paul Burrows, and Bridie Jones. "Continuing Professional Development: Diabetes and associated diabetic emergencies." Journal of Paramedic Practice 11, no. 6 (2019): 1–5. http://dx.doi.org/10.12968/jpar.2019.11.6.cpd1.

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Overview Diabetes is a group of metabolic diseases characterised by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic complications of diabetes include accelerated development of cardiovascular disease, end-stage renal disease, loss of visual acuity, and limb amputations. However, in the acute situation, diabetes can result in conditions such as diabetic ketoacidosis and hyperosmolar hyperglycemic state, both of which have the same cause: insufficient insulin. This article explores the physiology of glucose control, the pathophysiology of diabetes

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Taveau, Christopher, Catherine Chollet, Daniel G. Bichet, et al. "Acute and chronic hyperglycemic effects of vasopressin in normal rats: involvement of V1A receptors." American Journal of Physiology-Endocrinology and Metabolism 312, no. 3 (2017): E127—E135. http://dx.doi.org/10.1152/ajpendo.00269.2016.

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Recent epidemiological studies have revealed novel relationships between low water intake or high vasopressin (AVP) and the risk of hyperglycemia and diabetes. AVP V1A and V1B receptors (R) are expressed in the liver and pancreatic islets, respectively. The present study was designed to determine the impact of different levels of circulating AVP on glucose homeostasis in normal Sprague-Dawley rats, as well as the respective roles of V1AR and V1BR. We showed that acute injection of AVP induces a dose-dependent increase in glycemia. Pretreatment with a selective V1AR antagonist, but not a V1BR a

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Kordrostami, Saba, Maryam Zahedi, Abdolhalim Rajabi, and Shahab Eskandari-Nejad. "Glycemic Characteristics and Clinical Outcomes in Patients with COVID-19 Admitted to Referral Shahid Sayad Shirazi Hospital in Gorgan, North of Iran." Interdisciplinary Perspectives on Infectious Diseases 2023 (November 6, 2023): 1–8. http://dx.doi.org/10.1155/2023/1374819.

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Background. Diabetes mellitus (DM) is one of the most common chronic diseases, the main manifestation of which is hyperglycemia, and is accompanied by many complications. Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, several studies have reported the occurrence of various complications associated with different degrees of hyperglycemia in COVID-19 patients. The aim of the present study was to investigate the glycemic characteristics and clinical outcomes in patients with COVID-19. Methods. In this cross-sectional study, 418 patients with COVID-19 were evaluated in ter

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Karam, Jocelyne Georges, Chinenye Uchenna Eze-Raphael, and Chrystel Calliste. "Hemi Chorea and Hemi Balllismus: A Rare Presentation of Prolonged Uncontrolled Hyperglycemia." Journal of the Endocrine Society 5, Supplement_1 (2021): A384. http://dx.doi.org/10.1210/jendso/bvab048.783.

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Abstract Background: Hemi chorea and hemiballismus interestingly, are rare presentations of severe chronic persistent hyperglycemia which resolves with correction of hyperglycemia in most cases. Clinical Case: Here we report a case of a 67 YO woman with a PMH of prolonged uncontrolled DM evidenced by average baseline HbA1c of 14.6% (n&lt;5.7%) presenting with dance-like movements of the left arm and mouth deviation. Initially the patient presented as a stroke code. Vital signs were unremarkable. On Physical exam, there was mild L face weakness and obvious abnormal hand movement. Other neur

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Cho, Hyun, Young Seok, Hae Lee, Minji Song, and InKyeom Kim. "Repression of Transcriptional Activity of Forkhead Box O1 by Histone Deacetylase Inhibitors Ameliorates Hyperglycemia in Type 2 Diabetic Rats." International Journal of Molecular Sciences 19, no. 11 (2018): 3539. http://dx.doi.org/10.3390/ijms19113539.

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Type 2 diabetes mellitus (T2DM) is a chronic disease manifested by hyperglycemia. It is essential to effectively control hyperglycemia to prevent complications of T2DM. Here, we hypothesize that repression of transcriptional activity of forkhead box O1 (FoxO1) via histone deacetylase inhibitors (HDACi) ameliorates hyperglycemia in T2DM rats. Methods: Male Long-Evans Tokushima Otsuka (LETO) and Otsuka Long-Evans Tokushima Fatty (OLETF) rats aged 14 weeks were administered sodium valproate (VPA, 0.71% w/v) dissolved in water for 20 weeks. Electrophoretic mobility shift assay (EMSA) and luciferas

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Hirose, Ryutaro, Fengyun Xu, Kim Dang, et al. "Transient Hyperglycemia Affects the Extent of Ischemia-Reperfusion-induced Renal Injury in Rats." Anesthesiology 108, no. 3 (2008): 402–14. http://dx.doi.org/10.1097/aln.0b013e318164cff8.

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Background Chronic hyperglycemia is known to increase renal injury, particularly during ischemia-reperfusion episodes. The goal of this study was to examine whether transient hyperglycemia during or after renal ischemia-reperfusion increased renal dysfunction. Methods Male Lewis rats underwent sham operations or unilateral nephrectomies followed by contralateral renal ischemia-reperfusion. Hyperglycemic rats were given 25% dextrose to induce transient hyperglycemia lasting throughout the duration of ischemia (PI rats) or beginning 2 h after initiation of reperfusion (PR rats). Additional vehic

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Ramakrishnan, R., M. Y. Nazer, N. Suthanthirarajan, and A. Namasivayam. "An Experimental Analysis of the Catecholamines in Hyperglycemia and Acidosis-Induced Rat Brain." International Journal of Immunopathology and Pharmacology 16, no. 3 (2003): 233–39. http://dx.doi.org/10.1177/039463200301600308.

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Hyperglycemia and acidosis are the hallmarks of diabetes. Since these factors play an important role in diabetic complications, we have studied the brain catecholamine levels in hyperglycemic and acidotic conditions per se. Experimentally induced hyperglycemia and acidosis are accompanied by significant alterations in the catecholamine levels in discrete areas of the brain. We and others have shown that chronic or acute diabetes in animals, as well as in humans results in altered neurotransmitter levels. In the present study, hyperglycemia maintained by daily external administration of glucose

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Čugalj Kern, Barbara, Katarina Trebušak Podkrajšek, Jernej Kovač, et al. "The Role of Epigenetic Modifications in Late Complications in Type 1 Diabetes." Genes 13, no. 4 (2022): 705. http://dx.doi.org/10.3390/genes13040705.

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Type 1 diabetes is a chronic autoimmune disease in which the destruction of pancreatic β cells leads to hyperglycemia. The prevention of hyperglycemia is very important to avoid or at least postpone the development of micro- and macrovascular complications, also known as late complications. These include diabetic retinopathy, chronic renal failure, diabetic neuropathy, and cardiovascular diseases. The impact of long-term hyperglycemia has been shown to persist long after the normalization of blood glucose levels, a phenomenon known as metabolic memory. It is believed that epigenetic mechanisms

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