Relevant bibliographies by topics / Chronic immobilization stress

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Academic literature on the topic 'Chronic immobilization stress'

Author: Grafiati
Published: 4 June 2025
Last updated: 23 June 2025

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Journal articles on the topic "Chronic immobilization stress"

1

JUNJUA, BASHIR AHMAD. "ACUTE AND CHRONIC IMMOBILIZATION STRESS;." Professional Medical Journal 20, no. 01 (2012): 150–55. http://dx.doi.org/10.29309/tpmj/2013.20.01.580.

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ABSTRACT…Objective: To compare the morphological changes induced by acute and chronic immobilization in vermal cerebellarcortex of young male sprague dawley rats with special reference to Purkinje cells. Study design: It was experimental. Setting:Department of Anatomy CPSP Reional Centre, Islamabad. Period: 2005 to 2007. Material and method: A total of 120 young maleSprague Dawley rats were taken and divided equally in two groups (n=60 in each). Both these groups were divided further into twosubgroups (n=30 in each) control acute (CA), immobilized acute (IA), control chronic (CC) and immobilized chronic (IC). ‘Immobilizedacute’ group IA was kept in restrainer for 24 hours continuously while ‘immobilized chronic’ group IC was kept in restrainer for 2 hoursdaily for fourteen days, one rat per restrainer separately. Sections stained with Hematoxylin and Eosin were studied under lightmicroscope for observations and data was recorded. Results of experimental acute group were compared with those of experimentalchronic’. SSPS version 10 was used for data analysis. Results: Changes in the shape and size of the soma and nucleus of the Purkinjecells were noted. The cells were looking like dried raisins in both experimental groups but these changes were more marked in acuteexperimental group as compared to controls. The size of the soma and nucleus of the Purkinje cells was reduced in both acute and chronicimmobilized stressed groups’ however; this reduction in the size of the soma and nucleus of the Purkinje cells was more pronounced inacute stressed group as compared to animals exposed to chronic stress. Total cell count and cell size was significantly decreased in bothexperimental groups as compared to their controls; however, it was more pronounced in acute stressed group as compared to animalsexposed to chronic stress. Conclusions: Immobilization stress may act as a factor causing an imbalance in the metabolic activity of theneurons which can result in neuronal injury. The Purkinje neurons were affected more under the effect of acute stress as compared tochronic. The lesser effect in chronic stress is probably due to role of the phenomena of adaptation.
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2

JUNJUA, BASHIR AHMAD. "ACUTE AND CHRONIC IMMOBILIZATION STRESS;." Professional Medical Journal 19, no. 06 (2012): 848–53. http://dx.doi.org/10.29309/tpmj/2012.19.06.2466.

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Objective: The purpose of this article is to compare the morphological changes induced by acute immobilization with thoseproduced by chronic immobilization, in vermal cerebellar cortex of young male sprague dawley rats. Study design: Experimental study.Setting: Department of Anatomy CPSP Regional Centre, Islamabad. Period: 2005 to 2007. Material and method: A total of 120 young maleSprague Dawley rats were taken and divided equally in two groups for acute and chronic immobilization stress. Both these groups were dividedfurther into two subgroups (n=30 in each) control acute, experimental acute, control chronic and experimental chronic. ‘Experimental acute’group Ib was kept in restrainer for 24 hours continuously while ‘experimental chronic’ group IIb was kept in restrainer for 2 hours daily forfourteen days, one rat per restrainer separately. Hematoxylin and Eosin stained sections were studied under light microscope to record thedata. Results of experimental acute group were compared with those of experimental chronic’. Data was analyzed by SSPS version 10.Results: Insignificant increase in thickness of vermal cerebellar cortex and molecular layer was found in both acute and chronically stressedrats; but comparatively more in group Ib, however minimal non significant change in granular layer was seen in both experimental groups.Conclusions: Immobilization stress can cause the neuronal injury. Acute stress tends to produce more severe effects on brain cortical tissueas compared with chronic stress. The reason for occurrence of less severe effects under chronic stress is probably due to role of thephenomena of adaptation.
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3

Roger, Sebastien Ndjock, Clarisse Okomolo Moto Fleur, Pierre Omam Omam Jean, Stephanie Kameni Njapdounké Jacqueline, Mbom Alain, and Ngo Bum Elisabeth. "Effects of Phragmanthera capitata (Loranthaceae) on a model of anxiety-like behaviours induced by chronic immobilization stress in mice." GSC Advanced Research and Reviews 17, no. 2 (2023): 129–43. https://doi.org/10.5281/zenodo.10614964.

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This work aims to evaluate the anxiolytic-like effects of&nbsp;<em>Phragmanthera capitata</em>&nbsp;in a model of chronic immobilization stress in mice. Groups of mice were treated in ten consecutive days as follows: a normal control group (NaCl 0.9% per os), a negative control group (chronic immobilization stress + NaCl 0.9% per os), three test groups that were submitted to chronic immobilization stress (CIS) and received three doses of the plant (25, 125, and 250 mg/kg, p.o), and a positive control group (chronic immobilization stress + diazepam 2 mg/kg, i.p). Open field and dark/light tests were used for the evaluation of anxiolytic effects. Antioxidant activities and the involvement of gabaergic neurotransmission were determined by measuring the levels of malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), gamma amino butyric acid (GABA), and GABA-transaminase (GABA-T) in the brain. Our results show that the highest dose of&nbsp;<em>Phragmanthera capitata</em>&nbsp;induced a significant increase (p &lt; 0.001) of time spent in the centre, number of crossing and number of grooming in the open field test and a significant increase (p &lt; 0.001) of time spent in the light compartment and the latency of the first escape in the light compartment of the dak/light test. The level of MDA and the activity of GABA-T were significantly decreased by the&nbsp;<em>Phragmanthera capitata</em>&nbsp;while reduced GSH, CAT and GABA, levels were increased. These results suggest that&nbsp;<em>Phragmanthera capitata</em> possesses anxiolytic-like effects that may be supported by its antioxidant activities and or the GABA neurotransmission.
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4

Bitgul, Gulsah, Isil Tekmen, Didem Keles, and Gulgun Oktay. "Protective Effects of Resveratrol against Chronic Immobilization Stress on Testis." ISRN Urology 2013 (November 6, 2013): 1–10. http://dx.doi.org/10.1155/2013/278720.

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Objective. The aim of this study was to investigate protective effects of resveratrol, a strong antioxidant, against possible negative effects of chronic immobilization stress on testes of male rats histochemically, immunohistochemically, ultrastructurally, and biochemically. Material and Methods. Male Wistar rats were divided into 4 groups (n=7). Group I, control group (C), was not exposed to stress. Group II, stress group (S), was exposed to chronic immobilization stress. In Group III, low dose resveratrol + stress group (LRS), rats were given 10 mg/kg/day resveratrol just before the stress application. In Group IV, high dose resveratrol + stress group (HRS), rats were given 20 mg/kg/day resveratrol just before the stress application. For chronic immobilization stress application animals were put in the plastic tubes (6 cm in diameter, 15 cm in length) during 32 days for 6 hours. All animals were sacrificed 18 hours after the last stress application. Results. Histochemical and ultrastructural investigations showed that in stress group there was germ cell deprivation in seminiferous tubules and increase of connective tissue on interstitial area. No significant changes were seen in low and high dose resveratrol groups. After immunohistochemical investigations, TUNEL (+) and Active Caspase-3 (+) cells were increased in seminiferous tubules of stress group compared with those control group, but they were decreased in low and high dose resveratrol groups. According to biochemically results, MDA, GSH, and testosterone levels in stress group showed no significant difference when compared with those of the other groups. Conclusion. The chronic immobilization stress increases oxidative stress and apoptosis and causes histological tissue damages; resveratrol can minimize the histological damage in testes significantly.
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5

Himcheva, Ivelina, Galya Tz. Stavreva, Emilia Naydenova, and Adriana Bocheva. "Involvement of the opioidergic and nociceptinergic systems in the analgesic effects of novel nociceptin analogues after acute and chronic immobilization stress." Pharmacia 69, no. (4) (2022): 935–42. https://doi.org/10.3897/pharmacia.69.e89379.

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Stress is known to exert an influence on neuroendocrine, autonomic, hormonal functioning. Various stress models have been reported to induce analgesia. This is a phenomenon, referred to as stress-induced analgesia (SIA). Nociceptin/Orphanin FQ(N/OFQ) is a heptadecapeptide that has been found to play a direct role on pain perception. This study aimed to investigate the effects of novel nociceptin analogues on nociception after acute and chronic immobilization stress (CIS) and the involvement of the opioid and nociceptinergic systems in analgesic effects. Analgesic effects were examined by paw-pressure (PP) and hot-plate (HP) tests. Our data showed that acute immobilization stress induced hypoalgesia. The analgesic effect was more pronounced in pain caused by a mechanical stimulus than by a thermal one. CIS attenuated the hyperalgesic effect of naloxone and JTC-801 for mechanical and thermal stimulation. The effects of the opioid system are more pronounced in acute immobilization stress, while the nociceptin mechanisms predominate after chronic stress.
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6

Patidar, Govind, and ANIS Shaikh. "Antistress Potential of Glycyrrhizin in Chronic Immobilization Stress." Biomedical & Pharmacology Journal 5, no. 2 (2012): 273–83. http://dx.doi.org/10.13005/bpj/355.

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7

Oksana, Mishchenko, Zaychenko Ganna, Sharifov Churshed, Koshova Оlena, Larianovskaya Julia, and Khalieieva Olena. "Influence of extract of peach ordinary (persica vulgaris) leaves on the state of thymic-lymphatic element of the immune system of rats in conditions of chronic immobilization stress." ScienceRise: Pharmaceutical Science, no. 3(13) (June 29, 2018): 13–18. https://doi.org/10.15587/2519-4852.2018.135748.

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<strong>The aim</strong>&nbsp;&ndash; study of the influence of thick extract of peach ordinary (Persica vulgaris) leaves (TEPL) on the state of thymic-lymphatic element of the immune system of rats in conditions of chronic immobilization stress. <strong>Materials and methods.</strong>&nbsp;The model of chronic immobilization stress was reproduced for 18 days by daily four hour immobilization of rats in tight box. Investigated TEPL, which was obtained at the Department of Chemistry of Natural Compounds of National University of Pharmacy from peach leaves of the Salve variety harvested in Tajikistan was administered intragastrically in a conditionally effective dose of 100 mg/kg. Reference drug the syrup &laquo;Immuno-Ton&raquo; was used in a dose of 3 ml/kg.<strong>&nbsp;</strong>The state of thymic-lymphatic element of the immune system in conditions of chronic immobilization stress was determined after the euthanasia of animals under mild inhalation anesthesia by the results of the study of the coefficients of thymus and spleen mass and histological studies on micropreparations, which were prepared according to the generally accepted method. To assess the nature of the effect of the TEPL on the condition of the organs of the rat thymic-lymphatic system under chronic immobilization stress conditions, a comparison was made with intact control and control pathology. <strong>Results.</strong>&nbsp;It was determined that chronic immobilization stress had suppressive effect on the thymic-lymphatic element of the immune system. An increase in the width of the marginal zone of lymphoid follicles and muft and the number of perivascular lymphatic clusters 1.2 times (p &lt;0.05) compared with control pathology, reduction of signs of stressful hypoxia - the number of structures of white pulp with spasm of the central arteries was noted in the spleen. Reducing the degree of change from the third to fourth phase to the first phase of the accident transformation is set in the thymus, which is confirmed by an increase in the mass of the thymus mass by 2.7% in comparison with the control pathology. <strong>Conclusions.</strong>&nbsp;The ability of TEPL to restore impaired activity of organs of thymic-lymphatic element of the immune system has been proved. It is likely, that polyphenolic compounds of TEPL exhibit antioxidant properties, enhancing the activity of the antioxidant system, and polysaccharides exhibit immunostimulative properties, the result of which is a stressprotective action. The effectiveness of TEPL was not inferior to the reference drug &laquo;Immuno-Ton&raquo;
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8

Valeeva, E. V., I. Kh Valeeva, I. I. Semina, et al. "Dopamine receptors genes activity under chronic stress in rats." Biomics 13, no. 1 (2021): 1–7. http://dx.doi.org/10.31301/2221-6197.bmcs.2021-1.

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Stress response is a multifactorial condition which is formed under extreme environmental exposure due to various neuroendocrine systems interactions. Dopaminergic system plays a key role in stress response through the dopamine which effect is realized after binding with special dopamine receptors types D1-D5. Expression of these receptors varies in different tissues, organs and specific brain structures but there is a special interest in their genes expression level in peripheral blood that can be served as additional marker to evaluate the chronic stress degree. Herein we determine the influence of various types induced chronic stress exposure during 6 months (such as exhausting physical activity (forced swimming), immobilization stress, and their combinations (swimming with immobilization)) on Drd1, Drd2 and Drd3 genes expression level in Wistar rats’ peripheral blood. According to our results, no activity for Drd2 and Drd3 genes is shown; however significant overexpression of Drd1 gene was detected in all studied groups after 3 months exposure compared to the data before experiment beginning, whereas after 6 months the relative expression level significantly decreased in the group with immobilization stress, which proves the negative effect of this type of chronic stress on the production of dopamine receptors of the D1 type. Thus, Drd1 gene activity in the blood can serve as a marker for assessing the severity of chronic stress in rats.
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9

Himcheva, Ivelina, Galya Tz Stavreva, Emilia Naydenova, and Adriana Bocheva. "Involvement of the opioidergic and nociceptinergic systems in the analgesic effects of novel nociceptin analogues after acute and chronic immobilization stress." Pharmacia 69, no. 4 (2022): 935–42. http://dx.doi.org/10.3897/pharmacia.69.e89379.

Full text
Abstract:
Stress is known to exert an influence on neuroendocrine, autonomic, hormonal functioning. Various stress models have been reported to induce analgesia. This is a phenomenon, referred to as stress-induced analgesia (SIA). Nociceptin/Orphanin FQ(N/OFQ) is a heptadecapeptide that has been found to play a direct role on pain perception. This study aimed to investigate the effects of novel nociceptin analogues on nociception after acute and chronic immobilization stress (CIS) and the involvement of the opioid and nociceptinergic systems in analgesic effects. Analgesic effects were examined by paw-pressure (PP) and hot-plate (HP) tests. Our data showed that acute immobilization stress induced hypoalgesia. The analgesic effect was more pronounced in pain caused by a mechanical stimulus than by a thermal one. CIS attenuated the hyperalgesic effect of naloxone and JTC-801 for mechanical and thermal stimulation. The effects of the opioid system are more pronounced in acute immobilization stress, while the nociceptin mechanisms predominate after chronic stress.
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10

Yamanaka, K., I. Muramatsu, and S. Kigoshi. "Effect of chronic nicotine treatment against repeated immobilization stress." Pharmacology Biochemistry and Behavior 26, no. 2 (1987): 259–63. http://dx.doi.org/10.1016/0091-3057(87)90115-8.

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Book chapters on the topic "Chronic immobilization stress"

1

Li, Xiao-Hong, Xue-Ming Zhou, Xiao-Juan Li, et al. "Effects of Xiaoyaosan on the Hippocampal Gene Expression Profile in Rats Subjected to Chronic Immobilization Stress." In Insights into the Prevention and Treatment of Depression with Famous TCM Prescription Xiaoyaosan. B P International (a part of SCIENCEDOMAIN International), 2023. http://dx.doi.org/10.9734/bpi/mono/978-81-19315-94-9/ch7.

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Zhu, Hui-Zheng, Yu-Dan Liang, Qing-Yu Ma, et al. "Xiaoyaosan Improves Depressive-like Behavior in Rats with Chronic Immobilization Stress through Modulation of the Gut Microbiota." In Insights into the Prevention and Treatment of Depression with Famous TCM Prescription Xiaoyaosan. B P International (a part of SCIENCEDOMAIN International), 2023. http://dx.doi.org/10.9734/bpi/mono/978-81-19315-94-9/ch6.

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Ma, Qingyu, Xiaojuan Li, Zhiyi Yan, et al. "Xiaoyaosan Ameliorates Chronic Immobilization Stress-Induced Depression-Like Behaviors and Anorexia in Rats: The Role of the Nesfatin-1-Oxytocin-Proopiomelanocortin Neural Pathway in the Hypothalamus." In Insights into the Prevention and Treatment of Depression with Famous TCM Prescription Xiaoyaosan. B P International (a part of SCIENCEDOMAIN International), 2023. http://dx.doi.org/10.9734/bpi/mono/978-81-19315-94-9/ch9.

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Conference papers on the topic "Chronic immobilization stress"

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Chen, Jia-xu, Jie Ding, Yuan Liang, et al. "Effect of Xiaoyaosan on Changes of Behavior in Chronic Immobilization Stress Rats." In 2009 2nd International Conference on Biomedical Engineering and Informatics (BMEI). IEEE, 2009. http://dx.doi.org/10.1109/bmei.2009.5305039.

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Chen, Jiaxu, Hegu Luo, Xin Zhao, Guangxing Yue, Jie Ding, and Yuan Liang. "Notice of Retraction: Study of the Plasma Metabolic Phenotype in Rats with Chronic Immobilization Stress." In 2008 Fourth International Conference on Natural Computation (ICNC). IEEE, 2008. http://dx.doi.org/10.1109/icnc.2008.123.

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Perevoznikov, I. E., T. S. Poleshchuk, and P. V. Velansky. "EFFECT OF CHRONIC IMMOBILIZATION STRESS AND 1-0-ALKYLGLYCEROLS ON FATTY ACID COMPOSITION OF RAT'S SPLEEN." In 90 лет - от растения до лекарственного препарата: достижения и перспективы. Федеральное государственное бюджетное научное учреждение "Всероссийский научно-исследовательский институт лекарственных и ароматических растений", 2021. http://dx.doi.org/10.52101/9785870191003_2021_596.

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