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Journal articles on the topic 'Chronic Proliferelative Periodontal Inflammatory Lesion'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

J Ford, Pauline, Erica Gemmell, and Gregory J Seymour. "The immunopathology of periodontal disease: links with atherosclerosis?" Microbiology Australia 26, no. 3 (2005): 127. http://dx.doi.org/10.1071/ma05127.

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Chronic inflammatory periodontal disease occurs as a result of an inflammatory response in the periodontium which is elicited by bacteria present in dental plaque. The specific cytokines and chemokines produced by this initial response cause a T cell/macrophage dominated inflammatory infiltrate to develop in the connective tissues. If this cell-mediated immune response does not control the bacterial challenge, progression to a B cell/plasma cell lesion occurs (reviewed in Gemmell et al. 20021). A component of the specific T cell and antibody response elicited by these bacteria however, has bee

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2

Smolyar, N. I., and M. M. Shylo. "Prevalence and structure of inflammatory periodontal diseases in tuberculosis in school-age children." Tuberculosis, Lung Diseases, HIV Infection, no. 3 (September 27, 2022): 39–44. http://dx.doi.org/10.30978/tb-2022-3-39.

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Objective — to study the prevalence and structure of inflammatory periodontal diseases in respiratory tuberculosis patients and infected with mycobacterium tuberculosis (MTB) school-aged children. Materials and methods. The examination was carried out in 168 (100 %) patients with respiratory tuberculosis and MBT-infected children and adolescents of school age (from 6 to 17 years) with inflammatory diseases of periodontal tissues. Among the examined schoolchildren, 102 (60.72 %) were school-aged children with respiratory tuberculosis (the first group). The second group included 66 (39.28

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Myhal, O. O., R. Z. Ogonovskyi, Z. M. Honta, K. A. Sichkoriz, K. A. Moroz, and O. Y. Kordiyak. "INDEX ASSESSMENT OF PERIODONTAL TISSUES AND DETERMINATION OF TREATMENT NEEDS IN PATIENTS WITH CHRONIC RHEUMATIC HEART DISEASE." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 24, no. 2 (2024): 80–86. http://dx.doi.org/10.31718/2077-1096.24.2.80.

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This study addresses the pressing scientific and practical issue in modern dentistry: enhancing dental care effectiveness for patients with chronic rheumatic heart disease. The purpose of this research is to comprehensively assess the condition of tooth-supporting tissues and quantify inflammatory phenomena in periodontal tissues among patients with chronic rheumatic heart disease, as well as to determine the necessary extent of periodontal care based on periodontal indices. Participants and methods. The periodontal tissues of 719 patients with chronic rheumatic heart disease from the Rheumato

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Gu, Ying, Hsi-Ming Lee, Nicole Napolitano, et al. "4-Methoxycarbonyl Curcumin: A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation." Mediators of Inflammation 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/329740.

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Chronic inflammatory diseases such as periodontitis have been associated with increased risk for various medical conditions including diabetes and cardiovascular disease. Endotoxin (lipopolysaccharide, LPS), derived from gram-negative periodonto-pathogens, can induce the local accumulation of mononuclear cells in the inflammatory lesion, increasing proinflammatory cytokines and matrix metalloproteinases (MMPs). This ultimately results in the destruction of periodontal connective tissues including alveolar bone. Curcumin is the principal dyestuff in the popular Indian spice turmeric and has sig

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Cortela, D. C. B., A. L. de Souza Junior, M. C. L. Virmond, and E. Ignotti. "Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review." Mediators of Inflammation 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/548540.

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Reactional episodes in leprosy are a result of complex interactions between the immune system,Mycobacterium leprae, and predisposing factors, including dental infections. To determine the main inflammatory mediators in the immunopathological process of dental infections and leprosy reactions, we conducted a systematic review of primary literature published between 1996 and 2013. A three-stage literature search was performed (Stage I, “leprosy reactions” and “inflammatory mediators”; Stage II, “dental infections” and “inflammatory mediators”; and Stage III, “leprosy reactions,” “dental infectio

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Barbudo-Selmi, Glenda Ramalho, Marileda Bonafim Carvalho, André Luis Selmi, and Silvio Emílio Cuevas Martins. "Periodontal disease characterization in dogs with normal renal function or chronic renal failure." Ciência Rural 34, no. 1 (2004): 113–18. http://dx.doi.org/10.1590/s0103-84782004000100017.

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The purpose of this study was to evaluate periodontal disease (PD) in dogs with chronic renal failure (CRF) and to compare it to PD in dogs with normal renal function (NRF). Twelve dogs with CRF and 24 dogs with NRF, all presenting dental pocket formation, were compared. In all dogs, serum creatinine, blood urea nitrogen, urine specific gravity and total red and white blood cells were determined. A complete oral examination was also performed including evaluation of bacterial plaque, gingivitis, gingival recession, pocket, calculus, dental mobility, dental loss, and ulcers. These data were use

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Moroz, P. I., A. K. Iordanishvili, V. A. Prohodnaya, S. Yu Maxyukov, A. V. Safronenko, and E. Sh Gulyaeva. "Features of clinical course and treatment principles of endodontic-periodontal lesions." Kazan medical journal 99, no. 3 (2018): 362–68. http://dx.doi.org/10.17816/kmj2018-362.

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Aim. To study the characteristic differences in the clinical course of chronic generalized periodontitis in the presence of periapical infection focus and the principles of combined treatment of endodontium and periodontium. Methods. A clinical and X-ray examination of 1525 patients of different age groups was performed. As a result, a clinical group of 68 patients with chronic generalized moderate and severe periodontitis was formed, who were divided into two groups depending on the presence or absence of periapical destruction. In group 1, 32 patients with the presence of chronic generalized

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8

Boșca, Adina Bianca, Elena Dinte, Carmen Mihaela Mihu, et al. "Local Drug Delivery Systems as Novel Approach for Controlling NETosis in Periodontitis." Pharmaceutics 16, no. 9 (2024): 1175. http://dx.doi.org/10.3390/pharmaceutics16091175.

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Periodontitis is a chronic inflammation caused by periodontopathogenic bacteria in the dental biofilm, and also involves the inflammatory-immune response of the host. Polymorphonuclear neutrophils (PMNs) play essential roles in bacterial clearance by multiple mechanisms, including the formation of neutrophil extracellular traps (NETs) that retain and destroy pathogens. During PD progression, the interaction between PMNs, NETs, and bacteria leads to an exaggerated immune response and a prolonged inflammatory state. As a lesion matures, PMNs accumulate in the periodontal tissues and die via NETo

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Kopetsky, Igor S., Lyudmila V. Pobozhieva, Alyona I. Kopetskaya, and Juliya V. Shevelyuk. "Problems of dental preservation and complex therapy of chronic generalized periodontitis." Medical Journal of the Russian Federation 27, no. 1 (2021): 71–78. http://dx.doi.org/10.17816/0869-2106-2021-27-1-71-78.

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Epidemiological studies have reported the prevalence of inflammatory periodontal diseases of 85%90% in individuals aged 30 years. Predicting the possibility of preserving teeth is an important integral part of treatment planning for periodontitis. Traditionally, the prognosis is based on the likelihood of tooth loss. The article presents a review of the literature characterizing the factors that affect the prognosis of the service life of teeth in case of periodontitis. For the literature review, a literature search was performed on the MedLine, EMBASE, CyberLeninka, and eLibrary databases. Th

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Eldzharov, Artem, Dzerassa Kabaloeva, Dmitry Nemeryuk, et al. "Evaluation of Microcirculation, Cytokine Profile, and Local Antioxidant Protection Indices in Periodontal Health, and Stage II, Stage III Periodontitis." Journal of Clinical Medicine 10, no. 6 (2021): 1262. http://dx.doi.org/10.3390/jcm10061262.

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Periodontitis, initiated by the subgingival biofilm and modified by the individual’s inflammatory/immune response, has been associated with vascular dysfunction. To analyze microcirculation indices in periodontal tissues and determine the activity of the enzymatic component of antioxidant defense and humoral immunity factors, a single-blind non-invasive clinical trial was realized. Forty subjects, aged from 30 to 65 years, with moderate to severe chronic periodontitis (chronic generalized periodontitis, CGP) vs. 40 subjects as periodontally healthy were recruited. Information such as capillary

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Rania, Mkaddem, Mabrouk Rim, and Frih Nadia. "Clinical Management of Internal Inflammatory Perforating and Non Perforating Root Resorption Associated With an Apical Resorption and a Cystic Lesion: A Case Report." EAS Journal of Dentistry and Oral Medicine 4, no. 5 (2022): 118–22. http://dx.doi.org/10.36349/easjdom.2022.v04i05.001.

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Root resorption has been defined as the loss of dental hard tissue dentin and cementum as a result of osteoclastic cell action according to the glossary American association, of endodontics. It can occur following dental trauma; orthodontic treatment or chronic infection of the pulp and periodontal structure. It can lead to the loss of the tooth if untreated. Post traumatic root resorption could be challenging. The cone beam computed tomography allows making a reliable differential diagnosis between internal and external resorption as well to assess the extent of the lesion and the thickness o

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Hadad, Henrique, Laís Kawamata de Jesus, Ana Flávia Piquera Santos, et al. "Unusual Ludwig´s angina in systemic disabled patient related with periodontal disease." Research, Society and Development 10, no. 5 (2021): e22510514896. http://dx.doi.org/10.33448/rsd-v10i5.14896.

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The Ludwig's angina is an infectious process involving submandibular, sublingual, and submental spaces bilaterally. They can rapidly progress to airway obstruction and hemodynamic instability. The most common cause of Ludwig's angina is apical dental infections, specifically involving the roots of second and third mandibular molars, which are contiguous to the submandibular space. Periodontal diseases are related with bone loss around dental roots and create a situation where the inflammatory drainage tends to assume a sulcular direction. The purpose of this article is to report a clinical pat

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Dholwani, Dimple, and Lalitagauri Mandke. "Persistent apical periodontits associated with endodontically treated teeth – A review." International Journal of Oral Health Dentistry 8, no. 4 (2022): 279–83. http://dx.doi.org/10.18231/j.ijohd.2022.053.

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Apical periodontitis, a chronic inflammatory lesion of the periradicular tissue, is caused by etiological agents of endodontic origin. It is considered as a potent communication between microbiological factors and defense system of the host at the interface of periodontal ligament and infected radicular pulp. Endodontic treatment failure is often characterized by the existence of post-treatment apical periodontitis, which may be persistent, recurrent or emergent. The major etiology of persisting disease is an intraradicular infection, however in certain cases a secondary intraradicular infecti

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Mudrov, V. P., N. V. Davidova, T. E. Mishina, and S. P. Kazakov. "Local cellular immune response in chronic periodontitis." Medical Immunology (Russia) 23, no. 6 (2021): 1389–94. http://dx.doi.org/10.15789/1563-0625-lci-2377.

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Microflora of the oral cavity forms a biofilm that induces response of immune system at the mucous membranes. Transition to periodontal lesion is provided by certain classes of resident mucosal immune cells and inflammatory/immune cells migrating to the periodont. In periodontal diseases, Th1, Th2, Th17, Treg are detected. T regulatory cells (Tregs) are proven to comprise the main anti-inflammatory cell population. Th17 cells and Treg cells play an important role in osteoclast differentiation. IL-17 secreted by Th17 cells affects osteoclastogenesis and may induce macrophages to enhance the loc

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Watri, Desi, How Kim Chuan, and Susanna Halim. "MANAGEMENT OF GINGIVAL ENLARGEMENT IN PATIENT WITH NON SURGICAL TREATMENT: A CASE REPORT." SCIENCE : Jurnal Inovasi Pendidikan Matematika dan IPA 5, no. 1 (2025): 425–32. https://doi.org/10.51878/science.v5i1.4748.

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Penyakit gingiva merupakan peradangan pada rongga mulut dan pembengkakan gingiva merupakan salah satu hal yang paling sering ditemukan. Pembesaran gingiva merupakan lesi inflamasi kronis yang disebabkan oleh plak bakteri dan kalkulus. Pembesaran gingiva muncul pada tingkat papila interdental dan/atau jaringan marginal gingiva, dapat terlokalisasi atau menyeluruh. Artikel ini mengkaji kasus pasien yang menderita pembesaran gingiva dan lesi gingiva yang disebabkan oleh plak bakteri. Kasus ini ditangani dengan perawatan periodontal nonsurgical. Selama lima hari, dilakukan terapi antibiotik dan te

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Janardhanan, Mahija, Rakesh Suresh, Vindhya Savithri, and Ravi Veeraraghavan. "Extranodal diffuse large B cell lymphoma of maxillary sinus presenting as a palatal ulcer." BMJ Case Reports 12, no. 2 (2019): bcr—2018–228605. http://dx.doi.org/10.1136/bcr-2018-228605.

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A multitude of disease processes ranging from periodontitis to malignancies can lead to formation of solitary ulcer on the palate. Hence solitary ulcers of palate can often be a challenging one to diagnose. We report an interesting case of a diffuse large B cell lymphoma of the maxillary sinus which perforated the palatal bone and presented clinically as a palatal ulcer. Initially the lesion manifested as a small ill-defined swelling in the posterior palatal slope in relation to 24and25 which were mobile and hence was erroneously diagnosed as chronic periodontal abscess. This paper is intended

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Mlachkova, Antoaneta, Christina Popova, and Velichka Doseva. "Presence of IL-8 Gene Polymorphism and IL-8 Serum Levels in Patients with Chronic Periodontitis - Literature Review." Folia Medica 62, no. 2 (2020): 253–57. http://dx.doi.org/10.3897/folmed.62.e47722.

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Multifactorial nature of chronic periodontitis is well known. The data indicate that the bacteria of subgingival biofilm (with their presence at high levels, too), as well as the immune response of the organism, genetic components and environmental factors play a significant role in the development of periodontal destructive disease. On the one hand the strong relationship between microorganisms from the &ldquo;red complex&rdquo; has been proved. On the other hand the initiation and progression of chronic periodontitis has been verified, as well. The presence of bacterial metabolic pro

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Figueredo, C. M., R. Lira-Junior, and R. M. Love. "T and B Cells in Periodontal Disease: New Functions in A Complex Scenario." International Journal of Molecular Sciences 20, no. 16 (2019): 3949. http://dx.doi.org/10.3390/ijms20163949.

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Periodontal disease is characterised by a dense inflammatory infiltrate in the connective tissue. When the resolution is not achieved, the activation of T and B cells is crucial in controlling chronic inflammation through constitutive cytokine secretion and modulation of osteoclastogenesis. The present narrative review aims to overview the recent findings of the importance of T and B cell subsets, as well as their cytokine expression, in the pathogenesis of the periodontal disease. T regulatory (Treg), CD8+ T, and tissue-resident γδ T cells are important to the maintenance of gingival homeosta

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Strobelt, Lisa, Anna-Maria Kuttenreich, Gerd Fabian Volk, Carien Beurskens, Thomas Lehmann, and Ina Manuela Schüler. "Oral health and oral health-related quality of life in patients with chronic peripheral facial nerve palsy with synkineses—A case-control-study." PLOS ONE 17, no. 11 (2022): e0276152. http://dx.doi.org/10.1371/journal.pone.0276152.

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Facial nerve palsy (FP) is the most common cranial nerve lesion, leading to partial or complete immobility of the affected half of face. If food residues on tooth surfaces cannot be removed by natural self-cleaning mechanisms that this is likely to lead to an increase dental plaque formation and the risk of dental, periodontal and general diseases. It was the aim of this study to assess oral health, oral hygiene with the influence of handedness and oral health related quality of life in patients with chronic peripheral FP. This study included 86 people. Patients with FP (n = 43) in an FP-group

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Kimak, Aleksandra, Barbara Tymczyna, Teresa Bachanek, Elżbieta Kimak, and Janusz Solski. "Chronic apical periodontitis as risk factor atherosclerosis and artery disease." Diagnostyka Laboratoryjna 53, no. 2 (2017): 79–84. http://dx.doi.org/10.5604/01.3001.0013.7966.

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Periodontitis is caused by bacteria that are present in periodontal tissues also under physiological condition. Neglected hygiene may increase the number of microorganisms and the formation of chronic apical periodontitis (CAP). The aim of the study was to evaluate changes in inflammatory expression (hsCRP and LpPLA2 in adult patients one year after the end of endodontic treatment, thereby the risk analysis of cardiovascular disease. Material and methods: Twenty-six patients who had history of inflammation outside the oral cavity were diagnosed with CAP before the treatment and one year after

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Sah, Sunita, Sajeev Shrestha, Pujan Acharya, and Khushbu Adhikari. "Comparison between Measurements of Clinical Attachment Level and Transgingival Probing with Alveolar Bone Crest Level in Chronic Periodontitis Patients." Journal of BP Koirala Institute of Health Sciences 6, no. 1 (2023): 33–37. http://dx.doi.org/10.3126/jbpkihs.v6i1.53685.

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Background: Periodontitis is an inflammatory disease of the supporting tissues of the teeth that leads to crucial changes in the bony architecture. Early detection is of great practical significance so that treatment may be administered before irreversible destruction could occur. Differences exist between different diagnostic methodology concerning the relationship between the measurements and the level of the lesion. The aim of this study was to assess relationship between clinical attachment level (CAL) and alveolar bone crest level (ABCL), reliability of transgingival bone probing level (T

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Arun, KV, Deepavalli Arumuga Nainar, and Swarna Alamelu. "Immunological Profile of Periapical and Periodontal Lesions: Current Concepts in the Role of T Cells." Journal of Operative Dentistry & Endodontics 1, no. 2 (2016): 70–75. http://dx.doi.org/10.5005/jp-journals-10047-0015.

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ABSTRACT Periapical lesions of endodontic origin and periodontitis are the two common chronic conditions that constitute the immunoinflammatory responses to putative oral pathogens. Both the conditions encompass similar patterns of development and pathologic mechanisms of host-mediated tissue destruction and subsequent establishment of the lesion. This host inflammatory response is attributed to a large array of immune cells that play a regulatory role in the protective and destructive pathways culminating in these two diseases. Hence, knowledge of the host response involved in their pathogene

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Sahoo, Nanda Kishore, Apoorva Mowar, Prajesh Dubey, and Isha Maheshwari. "An Audit of Histopathological Pattern of Peripheral Giant Cell Granuloma - A Retrospective Study." Annals of Maxillofacial Surgery 14, no. 1 (2024): 62–65. http://dx.doi.org/10.4103/ams.ams_20_24.

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Abstract Introduction: Peripheral giant cell granuloma (PGCG) is a type of reactive hyperplastic lesion in the oral cavity that develops due to local irritation or chronic trauma, originating from the periosteum or periodontal membrane. It primarily affects the alveolar mucosa of the posterior mandibular region and has a peak incidence in the age range of the fourth to sixth decades of life, with a 2:1 female predilection. The aim of the study was to analyse the histopathological pattern of peripheral giant cell granuloma. Materials and Methods: This retrospective study was conducted at a tert

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Jiang, Yanling, Luciano Magli, and Michael Russo. "Bacterium-Dependent Induction of Cytokines in Mononuclear Cells and Their Pathologic Consequences In Vivo." Infection and Immunity 67, no. 5 (1999): 2125–30. http://dx.doi.org/10.1128/iai.67.5.2125-2130.1999.

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ABSTRACT Viridans streptococci are a heterogeneous group of gram-positive bacteria that are normal inhabitants of the mouth. These organisms are thought to contribute significantly to the etiology of infective endocarditis, although recently they have been implicated in serious infections in other settings. Another group of oral bacteria, gram-negative anaerobes, is associated with chronic dental infections, such as periodontal diseases or endodontic lesion formation. We evaluated the ability of the oral pathogens Streptococcus mutans and Porphyromonas endodontalis to induce a pathogenic respo

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Shenoy, Santhosh, Madhurya N. Kedlaya, Sajna H. R., and Amitha Ramesh. "Oral Mucous Membrane Pemphigoid with Contact Dermatitis - A Rare Clinical Entity." Journal of Health and Allied Sciences NU 08, no. 03 (2018): 041–44. http://dx.doi.org/10.1055/s-0040-1708763.

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AbstractMucous membrane pemphigoid (MMP) is a rare inflammatory, autoimmune, subepithelial vesiculobullous lesion. Oral mucosa is affected in almost 90% of cases. Its development is chronic with a possible involvement of ocular, laryngeal and genital mucosa. Spontaneous remission is rare. Currently, improving oral hygiene, topical corticosteroid treatment is used to control the oral lesions of MMP. In the present case report, a 53 year old female patient with a known history of hypothyroidism reported to the department of Periodontology with a complaint of burning sensation and tenderness in t

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Marfiian, O. V., A. Ye Demkovych, Yu I. Bondarenko, and O. Z. Yaremchuk. "Modern views on the etiology and role of microbial persistence in the development of inflammatory processes in the periodontal complex (review)." Medicni perspektivi 29, no. 3 (2024): 27–35. http://dx.doi.org/10.26641/2307-0404.2024.3.313482.

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Alveolar tissue diseases cause the appearance of dentition defects, thereby reducing the patients' work capacity and quality of life. The purpose of this research was to investigate, modern views on the etiology of periodontitis and the role of microbial persistence in the development of inflammatory processes of periodontal complex basing on a review of literary sources. Literature review was conducted using PubMed, Web of Science, Scopus, Google Scholar from 2018 to March 2024. There were no restrictions on the date of publication or the language of scientific sources. Searches were conducte

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Marfiian, O.V., A.Ye. Demkovych, Yu.I. Bondarenko, and O.Z. Yaremchuk. "Modern views on the etiology and role of microbial persistence in the development of inflammatory processes in the periodontal complex (review)." Medicni perspektivi 29, no. 3 (2024): 27–35. https://doi.org/10.26641/2307-0404.2024.3.313482.

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Alveolar tissue diseases cause the appearance of dentition defects, thereby reducing the patients' work capacity and quality of life. The purpose of this research was to investigate, modern views on the etiology of periodontitis and the role of microbial persistence in the development of inflammatory processes of periodontal complex basing on a review of literary sources. Literature review was conducted using PubMed, Web of Science, Scopus, Google Scholar from 2018 to March 2024. There were no restrictions on the date of publication or the language of scientific sources. Searches were conducte

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Dumitrescu, Alexandra, Maria-Alexandra Martu, Alexandru Nemtoi, et al. "Association between Cone-Beam Computed Tomography and Histological and Immunohistochemical Features in Periapical Lesions Correlated with Thickened Maxillary Sinus Mucosa." Medicina 57, no. 8 (2021): 840. http://dx.doi.org/10.3390/medicina57080840.

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Background and Objectives: Odontogenic sinusitis is a frequently underestimated pathology with fewer symptoms in patients with periapical lesions, periodontal disease, or iatrogenic foreign bodies in the maxillary sinus. The aim of our study was to determine the correlation between maxillary sinusitis and periapical lesions using cone-beam computed tomography (CBCT) imaging and histological and immunohistochemical investigations. Materials and Methods: A total of 1450 initial patients diagnosed with maxillary sinusitis in the Ear-Nose-Throat (ENT) Department, University of Medicine and Pharmac

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Silva, Ana Paula da, Mariana Flores, Renata Mazaro, Flavia da Luz, Marcia Silva, and Rafael A. Fighera. "Oral lesions and retroviruses in shelter cats." Pesquisa Veterinária Brasileira 39, no. 7 (2019): 516–22. http://dx.doi.org/10.1590/1678-5150-pvb-5892.

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ABSTRACT: Oral lesions are common problems in feline medicine worldwide, and may be associated with different causes, such as infectious agents. There are only a few studies reporting the chief oral diseases and the results for retrovirus tests in shelter cats in Brazil, especially in the South region. This study aimed to identify the main inflammatory oral lesions in shelter cats and verify the test results for feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) infections. Forty-three felines from private shelters in the central region of Rio Grande do Sul state (RS) that pr

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Juan, Wang, Liu Qing, Yu Jinpin, Li Jialing, Chen Bin та Dong Yingchun. "IL-1β Expression and Change Following SRP in Gingival Crevicular Fluid in Patients with Periodontitis: A Systematic Review and Meta-Analysis". Sains Malaysiana 54, № 4 (2025): 1005–24. https://doi.org/10.17576/jsm-2025-5404-04.

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Periodontitis is a chronic inflammatory periodontal lesion, characterised by progressive destruction of connective tissue and continuous loss of marginal bone surrounding the teeth. Cytokines and chemokines play a role in the pathogenesis of chronic periodontitis (CP). Among these, IL-1β is considered one of the most important inflammatory factors and tissue-destructive cytokines. Despite numerous investigations identifying the role of IL-1β in gingival crevicular fluid (GCF) in bone resorption and connective tissue destruction, the efficacy of GCF IL-1β in assisting the diagnosis and predicti

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Villalon, Ma Melizza S., and Lei-Joan Vital. "Compound Odontoma of the Maxillary Sinus." Philippine Journal of Otolaryngology-Head and Neck Surgery 30, no. 1 (2015): 63–66. http://dx.doi.org/10.32412/pjohns.v30i1.399.

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In 1863, the term “odontoma” was introduced by Paul Broca which he described as a tumor formed by overgrowth of transitory or complete dental tissue. The World Health Organization classified them under mixed benign odontogenic tumors because of their origin from epithelial and mesenchymal cells, exhibiting different structures of dental tissue (enamel, dentin, cementum and pulp).1 There are two distinct types: compound and complex. Compound odontoma is composed of all odontogenic tissue in an orderly fashion resulting in many teeth-like structures but with no morphological resemblance to norma

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Matsuda, S., K. Nakano, H. Tsujigiwa, et al. "Overview of Cytological Dynamics of Periodontal Ligament Inflammatory Lesions." September 8, 2016. https://doi.org/10.19070/2377-8075-SI09001.

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Cyto-pathological features of the periodontal ligament tissue inflammatory lesions have somehow been carried out but detailed cellular dynamics remain unclear. Therefore, in this review, we overviewed mainly our recent experimental model studies. That is performed using using ordinary ddY mice and BMP bone marrow transplanted mouse model. Regaring the experimental apical inflammatory periodontitis, at four weeks, micro-CT confirmed the presence of a radiolucent image at the apex of the tooth, which was then removed for histological examination. The results showed granulation tissue with fibros

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Mestrinho, Lisa A., Joana Travancinha, and Cristina Sobral. "A case report of leishmaniosis with primary oral manifestation in a cat." Frontiers in Veterinary Science 9 (November 29, 2022). http://dx.doi.org/10.3389/fvets.2022.1059803.

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A case of leishmaniosis with primary oral manifestations was reported in a 10-year-old neutered domestic shorthair cat. The primary lesion was a maxillary nodular lesion, painful with spontaneous bleeding associated with advanced periodontal disease, which did not resolve with tooth extraction or periodontal treatment. Biopsy revealed chronic neutrophilic and macrophagic infections and amastigote forms of Leishmania sp and molecular tests were able to identify Leishmania infantum. Oral signs resolved after the initiation of etiologic treatment with allopurinol. Distinguishing oral signs of lei

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Dr., Vivek Krishna Patil Dr.Sneha Puri Dr.Janhavi Kawtikwar Dr.Kishori Jaytalkar. "Lateral Periodontal Cyst: A Rare Developmental Odontogenic Lesion – A Case Report"." May 3, 2025. https://doi.org/10.5281/zenodo.15332442.

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<strong>Abstract</strong>Lateral periodontal cyst (LPC) is an uncommon, non-inflammatory developmental odontogenic cyst that typically occurs along the lateral aspect of the root of a vital tooth, most frequently in the mandibular canine-premolar region. This paper presents a rare case of infected LPC in a 44-year-old female, who reported with a painless swelling on the buccal aspect of the right mandibular premolar region. Clinical examination revealed a well-circumscribed, fluctuant swelling between teeth #44 and #45. Radiographic and CBCT findings showed a well-defined radiolucency with sig

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Barbosa De Accioly Mattos, Marcelo, Camila Bernardo Peixoto, José Geraldo de Castro Amino, et al. "Coronary atherosclerosis and periodontitis have similarities in their clinical presentation." Frontiers in Oral Health 4 (January 16, 2024). http://dx.doi.org/10.3389/froh.2023.1324528.

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BackgroundPeriodontitis (PE) and coronary heart disease (CHD) possess multiple mechanisms for a putative association. This case-control study compared the periodontal status among CHD subjects to controls without CHD, while also investigating atheroma invasion by known periodontal pathogens.Methods161 subjects participated in this study were divided into three CHD groups: No CHD, chronic CHD, acute CHD. Additional analysis involved grouping subjects according to number of atheromas: no atheroma, 1–4 atheromas, 5–18 atheromas. Data were collected from medical records, periodontal examinations,

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Febbraio, Maria, and Paul M. Brown. "Abstract 180: Increased Atherosclerosis Associated with Periodontal Disease Is Mediated by CD36." Arteriosclerosis, Thrombosis, and Vascular Biology 32, suppl_1 (2012). http://dx.doi.org/10.1161/atvb.32.suppl_1.a180.

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We previously showed that inflammation, and not hyperlipidemia alone, was necessary for CD36 dependent atherogenesis. Chronic periodontal disease is characterized by a persistent inflammatory state and is epidemiologically associated with cardiovascular disease. We hypothesize that CD36 is an essential link between periodontal disease and atherosclerosis. Low density lipoprotein receptor knock out (LDLR KO) mice and CD36/LDLR double KO mice were infected with the periodontal disease associated bacteria, Porphyromonas gingivalis (Pg), by oral lavage and fed a Western diet for 12 weeks (n = 7-14

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Febbraio, Maria, and Paul M. Brown. "Abstract 644: CD36 is Essential to Increased Atherosclerosis Mediated by Oral Infection With Porphromonas gingivalis." Arteriosclerosis, Thrombosis, and Vascular Biology 34, suppl_1 (2014). http://dx.doi.org/10.1161/atvb.34.suppl_1.644.

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Epidemiological evidence strongly support a link between periodontal disease & cardiovascular disease, but the mechanism(s) remains poorly understood. Using the human periodontal disease associated bacteria, Porphyromonas gingivalis (Pg) as a model, we carried out studies in macrophages & low density lipoprotein receptor (LDLR) KO mice. Pg associated similarly with macrophages from wild type & CD36 KO mice, but there were differences in responses dependent on Toll-like receptor (TLR) 2. We observed decreased NFkB activation & IL1beta generation following Pg treatment in CD36 KO

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Chukkapalli, Sasanka, Irina Velsko, Mercedes Rivera-Kweh, Donghang Zheng, Alexandra Lucas, and Kesavalu Lakshmyya. "Abstract 14157: Periodontal Microbiome Induces Inflammation and Atherosclerosis in Hyperlipidemic Atherogenic Apoe Null Mice." Circulation 132, suppl_3 (2015). http://dx.doi.org/10.1161/circ.132.suppl_3.14157.

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Introduction: Periodontal disease (PD) is a polymicrobial dysbiotic chronic inflammatory disease produced by a complex subgingival microbiome, and is linked to systemic inflammatory atherosclerotic vascular disease (ASVD). American Heart Association supported the association between PD and ASVD but not causal association. Prior reports investigated the associations between these two diseases PD and ASVD. But the complex signaling molecules and mechanisms establishing a causal association are not well defined. Methods: To investigate how polybacterial infections initiate atherosclerotic plaque

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D.M., Xaydarova. "THE OBJECTIVE OF THIS STUDY IS TO ENHANCE THE EFFICACY OF DENTAL PULP LESION TREATMENT IN PATIENTS WITH CHRONIC PERIODONTITIS." May 25, 2025. https://doi.org/10.5281/zenodo.15511467.

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<em>One of the most prevalent dental pathologies, chronic inflammatory periodontal diseases continue to treat poorly. Although the microbial factor and occlusive disorders are generally acknowledged as contributing factors to the development of periodontal disease, somatic disorders are a significant aggravating factor. The challenge of diagnosing stomatogenic pathology is especially pertinent in patients with chronic somatic diseases of autoimmune origin, as their own immunity is significantly compromised. In recent years, there has been a significant amount of research conducted on the patho

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Osipova, Yu, L. Ostrovskaya, V. Morgunova, et al. "Clinical & Morphological Approach to Diagnosing Periodontium Inflammatory Diseases in Patients with Barrett’s esophagus." Journal of Clinical Physiology and Pathology 3, no. 1 (2024). http://dx.doi.org/10.59315/jiscpp.2024-3-1.35-41.

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Barrett’s esophagus (BE) is a facultative precancerous ailment affecting the distal esophagus and develops as a complication in 10-15% of patients suffering from gastroesophageal reflux disease (GERD). BE features metaplasia development, where flat differentiated cells are replaced with cylindrical differentiated ones. Inflammatory periodontal pathologies, which – given their high prevalence – are a serious medical and socioeconomic issue faced by society nowadays, account for not tooth loss only, yet also imply a negative impact involving the internal organs, the latter being explained throug

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O. P. Kobryn. "Evaluation of local immunity and level of endogenous intoxication in patients with generalized periodontitis and concomitant chlamydia infection." Bukovinian Medical Herald 18, no. 4 (72) (2014). http://dx.doi.org/10.24061/2413-0737.xviii.4.72.2014.190.

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It is defined the differences between the state of non-specific organism’s resistance and the level of endogenous intoxication in patients with generalized periodontitis (GP) and concomitant chlamydia infection. A thorough laboratory examination of 164 patients with GP of I and II stages of chronic course was conducted. To study the protective properties of periodontal tissue, nature of inflammatory response, level of phagocytosis we used the Yasinovskiy’s test (calculated migration of leukocytes in the oral cavity), we determined the concentration of lysozyme and secretory immunoglobulin A le

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Manish, Kumar, Nikita Raman, Abhishek Gautam, Samir Jain, Prakash Chandra Jha, and Amar Kumar. "A STUDY ON ASSOCIATION 0F TOOTH LOSS & PERIODONTAL DISEASE IN PATIENTS SUFFERING FROM DIABETES FROM BIHAR REGION." International Journal of Medical and Biomedical Studies 4, no. 2 (2020). http://dx.doi.org/10.32553/ijmbs.v4i2.977.

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Diabetes is one of the common diseases of modern times and one of the most common systemic disorder that is connected to periodontal disease. Periodontal diseases are bacterially induced chronic inflammatory diseases affecting the tissues surrounding and supporting the teeth. The lesion begins as gingivitis, an inflammation of the gingival tissues only, and may progress to periodontitis, where destruction of connective tissue attachment and alveolar bone can eventually lead to tooth loss. Hence based on above reported findings the present study was planned for study of prevalence of tooth Loss

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Yu, Ning, Audrey Rakian, Afsah Dean, and Thomas E. Van Dyke. "Specialized Proresolving Mediators Facilitate the Immunomodulation of the Periodontal Ligament Stem Cells." Frontiers in Dental Medicine 2 (November 15, 2021). http://dx.doi.org/10.3389/fdmed.2021.701197.

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Recent investigations into the regulation of the inflammation in the periodontitis have revealed that chronic inflammatory diseases such as periodontitis are characterized by an imbalance in the proinflammatory and proresolution mediators and can be characterized by a failure of the resolution pathways in the late stages of the acute inflammatory response. The proresolution mediators, termed as specialized proresolving mediators (SPMs), comprise the lipoxins, resolvins, protectins, and maresins that are derived from the arachidonic acid or omega-3 polyunsaturated fatty acids. In the animal stu

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N., Krishna Raj And K. Saraswathi Gopal. "COMPARISON OF CONVENTIONAL RADIOGRAPHY AND DIGITAL RADIOGRAPHY IN REGULAR AND REVERSAL IMAGE MODES FOR DETECTION OF PERIAPICAL PATHOLOGY USING INTRAORAL PERIAPICAL RADIOGRAPHS AND ALVEOLAR BONE LOSS DEPTH USING BITEWING RADIOGRAPHS." May 27, 2019. https://doi.org/10.5281/zenodo.3275051.

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Background: Periodontitis is an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms, resulting in destruction of the periodontal ligament and alveolar bone. Progressive loss of alveolar bone is the salient feature of periodontal disease. Accurate detection of periodontal disease with the use of radiographs helps in diagnosis, treatment and prognosis. Aim: The aim of the study is to analyze and compare the efficacy of conventional intraoral periapical(IOPA) and digital radiographs(PSP) in detecting periapical lesion and interdental bone loss depth in ch

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Vyshnevska, H. O., Z. Sh. Kakabadze, S. A. Schnayder, L. M. Zayats, O. I. Tiron, and R. S. Vastyanov. "A comparative study on the effectiveness of application of different types of biological matrixes on mandibular alveolar mucosa lesion healing." June 30, 2020. https://doi.org/10.12775/JEHS.2020.10.06.040.

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Vyshnevska H. O., Kakabadze Z. Sh., Schnayder S. A., Zayats L. M., Tiron O. I., Vastyanov R. S. A comparative study on the effectiveness of application of different types of biological matrixes on mandibular alveolar mucosa lesion healing. Journal of Education, Health and Sport. 2020;10(6):382-393. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.06.040 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.06.040 https://zenodo.org/record/4056927         The journal has had 5 points in Ministry of Science and Higher Education parametric evaluat

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Takagi, Ryo, Kosei Mori, Takashi Koike, et al. "A giant peripheral ossifying fibroma of the maxilla with extreme difficulty in clinical differentiation from malignancy: a case report and review of the literature." Journal of Medical Case Reports 18, no. 1 (2024). http://dx.doi.org/10.1186/s13256-024-04529-9.

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Abstract Background Peripheral ossifying fibroma is a nonneoplastic inflammatory hyperplasia that originates in the periodontal ligament or periosteum in response to chronic mechanical irritation. Peripheral ossifying fibroma develops more commonly in young females as a solitary, slow-growing, exophytic nodular mass of the gingiva, no more than 2 cm in diameter. While various synonyms have been used to refer to peripheral ossifying fibroma, very similar names have also been applied to neoplastic diseases that are pathologically distinct from peripheral ossifying fibroma, causing considerable n

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Dolgushin, I. I., and E. A. Mezentseva. "NEUTROPHIL GRANULOCYTES: PARTICIPATION IN HOMEOSTATIC AND REPARATIVE PROCESSES. PART II." Russian Journal of Infection and Immunity, June 26, 2019. http://dx.doi.org/10.15789/2220-7619-ngp-1258.

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A supportive homeostatic function of neutrophilic granulocytes is accomplished in the physiology of different tissues and body systems. Neutrophils are found along the entire female reproductive tract (FRT), gradually declining in numbers from the upper parts towards vagina. At the same time, both quantity and activity of FRT mucosal neutrophils are controlled by hormonal changes at different phases of menstrual cycle. Tissue neutrophils serve as an important source of broad-spectrum proteolytic enzymes such as matrix metal proteases and elastase necessary for extracellular matrix remodeling a

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Kudsi, Mayssoun, Louei Darjazini Nahas, Rama Alsawah, Ahmad Hamsho, and Abdullah Omar. "The prevalence of oral mucosal lesions and related factors in systemic lupus erythematosus patients." Arthritis Research & Therapy 23, no. 1 (2021). http://dx.doi.org/10.1186/s13075-021-02614-8.

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Abstract Background Systemic lupus erythematosus (SLE) is a chronic inflammatory multi systematic disease of unknown aetiology. SLE has a wide range of symptoms. The most common symptoms are joint pain, skin rash and fever. Oral lesions in SLE manifest in a variety of forms, such as oral mucosal ulceration, mouth burns, xerostomia and salivary gland diseases, temporomandibular joint disease, periodontal disease, dysgeusia, white lesions, oedema, bleeding and petechiae. Objective This study was conducted to evaluate the prevalence of oral mucosal lesions and their related factors in patients wi

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Sakis, Edardo Rebelato, Tanise Policarpo Machado, Diorges Henrique Setim, Luciante Melatti, and Adriana Costa Da Motta. "Feline Lymphoplasmacytic Gingivostomatitis: Clinical and Anatomopathological Aspects." Acta Scientiae Veterinariae 47 (December 11, 2019). http://dx.doi.org/10.22456/1679-9216.97544.

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Background: Feline lymphoplasmacytic gingivostomatitis (FLPG) is an idiopathic, multifactorial and highly challenging condition, since the results of the available treatments are partial and transitory. A set of lesions triggered by inflammatory reaction is observed, sometimes with ulcerations in the oral mucosa, leading to algia and discomfort. Histopathological examination figures as the definitive diagnostic tool, presenting distinct cellular elements. The present study aims to report three cases of FLPG, firstly addressing the anatomopathological findings, as well as the therapeutic approa

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SYED, AFFAN AKBAR. "Mitochondrial Metabolism of Mesenchymal Stem Cells: Implications for Age-Related Diseases." January 11, 2025. https://doi.org/10.5281/zenodo.14633072.

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<strong>ABSTRACT</strong> In the landscape of therapeutic strategies for age-related diseases, Mesenchymal stem cells (MSCs) have emerged as prominent contenders, showcasing notable efficacy, especially in the treatment of neurodegenerative disorders such as Parkinson's and Huntington's diseases. The potency of MSCs in therapeutic interventions is intimately linked to their mitochondrial metabolism, a pivotal factor that underpins the maintenance of cellular functions and facilitates responses to the challenges associated with aging. This comprehensive review meticulously explores the intricat

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