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Journal articles on the topic 'Chronic toxic damage'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Turayev, Shahkboz, and Maqsud Samadovich Hayitov. "SPECIFIC CHARACTERISTICS OF QUANTITATIVE CHANGES IN EXTRACELLULAR MATRIX COMPONENTS IN CHRONIC TOXIC LIVER INJURY." Multidisciplinary Journal of Science and Technology 5, no. 5 (2025): 1393–97. https://doi.org/10.5281/zenodo.15549516.

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This article presents an analysis of scientific sources regarding the quantitative changes of extracellular matrix components in liver tissue under chronic toxic damage. According to the research findings, prolonged exposure to toxic agents increases the levels of collagen, fibronectin, laminin, and proteoglycans, leading to the early development of liver fibrosis. The literature review serves as an important source for a deeper understanding of the morphological basis of liver injury, early diagnosis, and the development of effective therapeutic approaches.

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To'rayev, Shahzod, and Maqsud Samadovich Hayitov. "SPECIFIC CHARACTERISTICS OF QUANTITATIVE CHANGES IN EXTRACELLULAR MATRIX COMPONENTS IN CHRONIC TOXIC LIVER INJURY." Multidisciplinary Journal of Science and Technology 5, no. 5 (2025): 1491–95. https://doi.org/10.5281/zenodo.15562746.

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This article presents an analysis of scientific sources regarding the quantitative changes of extracellular matrix components in liver tissue under chronic toxic damage. According to the research findings, prolonged exposure to toxic agents increases the levels of collagen, fibronectin, laminin, and proteoglycans, leading to the early development of liver fibrosis. The literature review serves as an important source for a deeper understanding of the morphological basis of liver injury, early diagnosis, and the development of effective therapeutic approaches.

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3

Skuratov, A. G., A. N. Lyzikov, A. S. Shaforost, A. A. Zyatskov, and N. M. Golubykh. "Determination of the activity of pyruvate kinase isoforms in normal conditions, in toxic liver damage and during the process of its regeneration." Health and Ecology Issues, no. 3 (October 1, 2021): 116–23. http://dx.doi.org/10.51523/2708-6011.2021-18-3-14.

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Objective. To evaluate the activity of pyruvate kinase (PK) isoforms in normal conditions, in toxic damage of the liver and during its regeneration.Materials and methods. An experimental study was carried out on 45 Wistar rats. Toxic liver damage was induced by the intraperitoneal administration of carbon tetrachloride. Mechanical damage was simulated by the surgical resection of the liver. The levels of PK isoforms R/L and M in the blood serum and liver tissue of the laboratory animals were measured with an ELISA test.Results. It has been found that the level of PK isoform M signifcantly incr

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4

Sokolova, M. O., V. E. Sobolev, D. A. Reshetkina, and O. A. Nagibovich. "Toxic effect of organophosphate compounds on the kidneys." Bulletin of the Russian Military Medical Academy 22, no. 3 (2020): 199–205. http://dx.doi.org/10.17816/brmma50560.

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Abstract. The study describes: the toxic effect of organophosphate intoxication compounds on the human and animal organism, the contribution of organophosphate to the chronic kidney disease epidemiology and the acute kidney poisoning pathophysiology caused by organophosphate compounds. The study shows oxidative stress and systemic hemodynamic disturbance in the pathogenesis of organophosphate-induced kidney injury. We summarized effects of organophosphate substances on the structural and functional kidneys tissue characteristics in humans and animals. Biomarkers useful for early diagnosis of k

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Mukharjee, Suchismita, Sarbashri Bank, and Smarajit Maiti. "Chronic Tobacco Exposure by Smoking Develops Insulin Resistance." Endocrine, Metabolic & Immune Disorders - Drug Targets 20, no. 6 (2020): 869–77. http://dx.doi.org/10.2174/1871530320666200217123901.

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Background and Objectives: The present review critically discusses the high occurrence rate, insulin resistance and type-2 diabetes in tobacco exposed individuals. Tobacco extracts and smoke contain a large number of toxic materials and a significant number of those are metabolic disintegrators. Discussion: Glucose and lipid homeostasis is severely impaired by this compound. Tobacco exposure contributes to adverse effects by impairing the physical, biochemical and molecular mechanisms in the tissues. The immunological components are damaged by tobacco with high production of proinflammatory cy

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Aripov, A. N., O. A. Aripov, L. L. Akhunjanova, A. O. Nabiev, D. A. Nabieva, and T. T. Khamroev. "STUDY THE ANTIFIBROUS EFFICACY OF PLANT PROANTHOCYANIDIN IN RATS WITH CHRONIC HELIOTRINE LIVER DAMAGE." Frontline Medical Sciences and Pharmaceutical Journal 02, no. 05 (2022): 16–25. http://dx.doi.org/10.37547/medical-fmspj-02-05-03.

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Under experimental conditions, the effect of plant proanthocyanidin – yantacin isolated from a camel thorn plant (Alhagi pseudalhagi) – Yantacin, when administered orally at a dose of 100 mg / kg, on possible changes in the early stages of liver fibrosis that occurred against the background of chronic heliotrine hepatitis was studied. The studies were conducted on male rats with a body weight of 100 ±10 g. The effect of yantacin on the general and biochemical parameters of the blood, as well as the amount of NO – nitrates (in connection with lipoproteins), proteins in the blood against the bac

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Avdeeva, Marina G., M. I. Kulbuzheva, Ye I. Kolod’ko, N. V. Chernikova, and O. V. Zapashnyaya. "PROBLEMS OF TREATMENT OF TOXIC HEPATITIS ON THE BACKGROUND OF CHRONIC VIRAL LESION OF HCV-ETIOLOGY. CLINICAL EXAMPLE OF SUCCESSFUL THERAPY." Epidemiology and Infectious Diseases 23, no. 1 (2018): 50–56. http://dx.doi.org/10.17816/eid42644.

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Epidemiological and clinical-laboratory features of the course of drug-induced and viral liver damage are considered. Clinical observation of severe toxic liver damage in a patient suffering from chronic viral hepatitis “C” is given. The authors share the experience of successful therapy.

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Bubalo, N. M., and G. M. Balan. "Syndrome of intrahepatic cholestasis in patients with acute and chronic intoxication with pesticides." Ukrainian Journal of Modern Toxicological Aspects 81, no. 1 (2018): 39–48. http://dx.doi.org/10.33273/2663-4570-2018-81-1-39-48.

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Objective. To study the incidence and peculiarities of intrahepatic cholestasis (IHC) syndrome in patients with toxic liver damage in acute and chronic intoxications with pesticides and to substantiate rational methods of diagnosis and treatment. Material and methods. The incidence has been analysed with the description of IHC syndrome peculiarities in acute and remote periods in 238patients with acute poisoning with pesticides: 162 — herbicides based on 2,4-dichlorophenoxyacetic acid (2,4-D), 62 — phosphororganic pesticides (POP), 14 — synthetic pyrethroids (SP) and 70 — with chronic intoxica

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9

Velichko, Valentyna, Halyna Cornovan, Svitlana Kovalenko, and Halyna Danilchuk. "Evaluation of the Effectiveness and Safety of Combination Therapy Using Drugs Vazonat and Entrop in Patients with Chronic Toxic Liver Damage." Family Medicine, no. 5 (November 30, 2016): 98–102. https://doi.org/10.30841/2307-5112.5.2016.248795.

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<strong>The objective: </strong>to study the efficacy and safety of using in the complex treatment of cytoprotector Vazonat in combination with the nootropic medicine of entropy in patients with chronic toxic liver damage. <strong>Patients and methods. </strong>There were examined 60 patients (36 men and 24 women) with signs of liver toxicity in age from 35 to 63 years. The average age of the examined was 43.2±1.3 years. All patients were divided into two statistically homogeneous groups (main and control) for 30 people in each. Patients in both groups received diet therapy, h

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10

Kuznetsova, P. I., M. M. Tanashyan, and A. A. Kornilova. "Toxic encephalopathy in a clinicl case of polycythemia vera." Bulletin of Siberian Medicine 18, no. 4 (2020): 249–55. http://dx.doi.org/10.20538/1682-0363-2019-4-249-255.

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The article deals with a clinical case description of a female patient with toxic encephalopathy against the background of Ph-negative myeloproliferative diseases. The article discusses symptoms and neuroimaging of hepatic encephalopathy developed as a result of a shunt placed after portal vein thrombosis. The issues of etiology and pathogenesis of hepatic encephalopathy, principles of therapy, as well as the unique clinical picture of nervous system damage in this condition are also discussed. Data on the role of manganese in development of toxic encephalopathy, accumulation of paramagnetic s

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11

Sheremet, N. L., N. A. Khanakova, N. V. Zhorzholadze, and T. A. Nevinitsyna. "Clinical features of toxic optic neuropathies." Kazan medical journal 98, no. 3 (2017): 400–403. http://dx.doi.org/10.17750/kmj2017-400.

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Aim. To study the features of the clinical symptoms of toxic optic neuropathy.  Methods. 21 patients (42 eyes) with toxic optic neuropathy were examined with the use of standard ophthalmic exam, computer visual field test, spectral optical coherence tomography of the retina and optic nerve.  Results. Toxic optic neuropathies were caused by the acute (4 patients) or chronic (10 patients) alcohol intake, drug abuse (6 patients) and medications (ethambutol, 1 patient). In all patients bilateral visual deterioration with central scotomas with various levels of light sensitivity reducti

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12

Fimognari, Carmela. "Role of Oxidative RNA Damage in Chronic-Degenerative Diseases." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/358713.

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Normal cellular metabolism and exposure to ionizing and ultraviolet radiations and exogenous agents produce reactive oxygen species (ROS). Due to their reactivity, they can interact with many critical biomolecules and induce cell damage. The reaction of ROS with free nucleobases, nucleosides, nucleotides, or oligonucleotides can generate numerous distinct modifications in nucleic acids. Oxidative damage to DNA has been widely investigated and is strongly implicated in the development of many chronic-degenerative diseases. In contrast, RNA damage is a poorly examined field in biomedical researc

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13

Samarth, Ravindra M., Rajnarayan R. Tiwari, Gopesh Modi, et al. "Evaluation of Cytogenetic Alterations in Patients of Chronic Kidney Disease." Indian Journal of Nephrology 33, no. 4 (2023): 259–63. http://dx.doi.org/10.4103/ijn.ijn_130_22.

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Introduction: In recent years, there has been a rise in chronic kidney disease (CKD), and it has been estimated that by 2040, CKD will be the fifth most common cause of death globally. In addition to diabetes, hypertension, obesity, hyperlipidemia, and nonalcoholic fatty liver disease commonly associated with CKD, exposure to various toxins as a result of pollution or industrial disasters is also discussed as a cause for multi-organ pathology including kidneys. Although few cytogenetic studies were undertaken to assess the genetic damage in survivors of the disaster, no studies are available o

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14

Furdychko, Anastasia, Marta Ilchyshyn, Adriana Barylyak, Irena Fedun, and Lesya Khoroz. "Development features of periodontal tissues inflammatory diseases of nicotine-dependent patients with chronic toxic hepatitis." SUCHASNA STOMATOLOHIYA 103, no. 4 (2020): 18–21. http://dx.doi.org/10.33295/1992-576x-2020-4-18.

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Introduction. Liver diseases and pathology of the organs of mouth cavity are interconnected. Smoking, usually increases the manifestations of the underlying disease and affects the course. The aim. To investigate the effect of chronic toxic hepatitis of nicotine-dependent patients and of patients without a bad habit on their periodontal status. Materials and methods. During the clinical examination of the oral cavity of 86 patients, the depth and incidence of inflammation of the gum were determined using the number of the Svrakov's number (SN); the conditions of hygiene of the oral cavity were

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15

Furdychko, Anastasia, Marta Ilchyshyn, Adriana Barylyak, Irena Fedun, and Lesya Khoroz. "Development features of periodontal tissues inflammatory diseases of nicotine-dependent patients with chronic toxic hepatitis." SUCHASNA STOMATOLOHIYA 104, no. 5 (2020): 26–29. http://dx.doi.org/10.33295/1992-576x-2020-5-26.

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Introduction. Liver diseases and pathology of the organs of mouth cavity are interconnected. Smoking, usually increases the manifestations of the underlying disease and affects the course. The aim. To investigate the effect of chronic toxic hepatitis of nicotine-dependent patients and of patients without a bad habit on their periodontal status. Materials and methods. During the clinical examination of the oral cavity of 86 patients, the depth and incidence of inflammation of the gum were determined using the number of the Svrakov's number (SN); the conditions of hygiene of the oral cavity were

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16

Rivadeneyra-Domínguez, Eduardo, José Eduardo Pérez-Pérez, Alma Vázquez-Luna, Rafael Díaz-Sobac, and Juan Francisco Rodríguez-Landa. "Effects of Cassava Juice (Manihot esculenta Crantz) on Renal and Hepatic Function and Motor Impairments in Male Rats." Toxins 12, no. 11 (2020): 708. http://dx.doi.org/10.3390/toxins12110708.

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Cassava (Manihot esculenta Crantz) is a plant that contains neurotoxins such as linamarin and lotaustraline. Its long-term consumption is associated with neuronal damage and contributes to the development of motor impairment in humans and rats. We investigated the effects of the consumption of cassava juice on renal and hepatic function and motor impairments in male rats. The rats received the vehicle, non-toxic and toxic doses of cassava juice, or linamarin as a pharmacological control, over 35 consecutive days. The effects were evaluated in an open field test, rotarod, and swim test. The tox

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17

Skosireva, O. V. "The late diagnosis of hemochromatosis in the patient with chronic hepatitis B and kidney damage Clinical Case Report." American Journal of Medical Sciences and Pharmaceutical Research 03, no. 04 (2021): 59–67. http://dx.doi.org/10.37547/tajmspr/volume03issue04-09.

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A late diagnosis of secondary hemochromatosis was made to a 38-year-old man with chronic hepatitis B, who after poisoning with alcohol surrogate (which was a year ago) had episodes of macrohematuria with signs of acute kidney damage, which required treatment in the ICU and hemodialysis sessions, after which kidney function was restored. In August 2020, the patient had a contact with a COVID-19 patient, but upon admission to the hospital, the results of tests for COVID-19 were negative. During the examination in our department, after the exclusion of the urological disease, the diagnosis of int

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18

Carson, D. A., S. Seto, and D. B. Wasson. "Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency." Journal of Experimental Medicine 163, no. 3 (1986): 746–51. http://dx.doi.org/10.1084/jem.163.3.746.

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The metabolic causes for immune impairment in patients with severe chronic inflammatory diseases have not been clearly defined. Recently, the overproduction of poly(ADP-ribose) in resting lymphocytes with unrepaired DNA strand breaks has been suggested to contribute to immune dysfunction in adenosine deaminase-deficient patients. Our experiments have determined to what extent DNA damage and poly(ADP-ribose) synthesis might also explain the impaired mitogen responsiveness of PBL exposed to toxic oxygen species. Treatment of normal resting human lymphocytes with xanthine oxidase and hypoxanthine

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19

Lindner, Maren, Jantje Fokuhl, Franziska Linsmeier, Corinna Trebst, and Martin Stangel. "Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination." Neuroscience Letters 453, no. 2 (2009): 120–25. http://dx.doi.org/10.1016/j.neulet.2009.02.004.

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20

Block, M. L., and J. S. Hong. "Chronic microglial activation and progressive dopaminergic neurotoxicity." Biochemical Society Transactions 35, no. 5 (2007): 1127–32. http://dx.doi.org/10.1042/bst0351127.

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PD (Parkinson's disease) is characterized by the selective and progressive loss of DA neurons (dopaminergic neurons) in the substantia nigra. Inflammation and activation of microglia, the resident innate immune cell in the brain, have been strongly linked to neurodegenerative diseases, such as PD. Microglia can respond to immunological stimuli and neuronal death to produce a host of toxic factors, including cytokines and ROS (reactive oxygen species). Microglia can also become persistently activated after a single stimulus and maintain the elevated production of both cytokines and ROS, long af

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Pérez-Martínez, J., FC Pérez-Martínez, B. Carrión, et al. "Aliskiren Prevents the Toxic Effects of Peritoneal Dialysis Fluids during Chronic Dialysis in Rats." Plos One 7, no. 4 (2012): e36268. https://doi.org/10.1371/journal.pone.0036268.

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Abstract The benefits of long-term peritoneal dialysis (PD) in patients with end-stage renal failure are short-lived due to structural and functional changes in the peritoneal membrane. In this report, we provide evidence for the in vitro and in vivo participation of the renin-angiotensin-aldosterone system (RAAS) in the signaling pathway leading to peritoneal fibrosis during PD. Exposure to high-glucose PD fluids (PDFs) increases damage and fibrosis markers in both isolated rat peritoneal mesothelial cells and in the peritoneum of rats after chronic dialysis. In both cases, the addition of th

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Tkachyshyn, V. S. "Internal organ damage in arsenic hydrogen intoxication." EMERGENCY MEDICINE 18, no. 7 (2022): 18–20. http://dx.doi.org/10.22141/2224-0586.18.7.2022.1526.

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Arsenic hydrogen is a colorless gas. It enters the body through the respiratory system, without irritating the mucous membranes of the upper respiratory tract. It is a poison with a primary hemolytic effect. In the body, arsenic hydrogen is oxidized to arsenic and excreted from the body mainly through the kidneys and intestines. The consequence of rapid and massive hemolysis is anemia, hypoxia, damage to parenchymal organs (kidneys, liver), nervous and cardiovascular system. In addition to hemolysis, a significant role is played by the direct toxic effect of arsenic, which is formed during the

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Filipets, N. D., L. І. Vlasyk, O. V. Herush, et al. "Experimental kidney pathology: models of the toxic nephropathies." One Health and Nutrition Problems of Ukraine 59, no. 2 (2023): 7–14. http://dx.doi.org/10.33273/2663-9726-2023-59-2-7-14.

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When conducting experimental studies, the question of an adequate model of renal pathology is problematic, therefore, the range of choice of methods of reproduction is extremely wide. The paper highlights the main modern methods of modeling and the principles of choosing a model of nephropathy for the study of changes in kidney functions and processes. It also investigates the effectiveness of pharmacological correction under the conditions of exposure to exotoxins. Attention is focused on models with predominant damage to nephron sections with established pathogenetic features of the course o

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Rodimova, Svetlana, Artem Mozherov, Vadim Elagin, et al. "Label-Free Imaging Techniques to Evaluate Metabolic Changes Caused by Toxic Liver Injury in PCLS." International Journal of Molecular Sciences 24, no. 11 (2023): 9195. http://dx.doi.org/10.3390/ijms24119195.

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Abuse with hepatotoxic agents is a major cause of acute liver failure. The search for new criteria indicating the acute or chronic pathological processes is still a challenging issue that requires the selection of effective tools and research models. Multiphoton microscopy with second harmonic generation (SHG) and fluorescence lifetime imaging microscopy (FLIM) are modern label-free methods of optical biomedical imaging for assessing the metabolic state of hepatocytes, therefore reflecting the functional state of the liver tissue. The aim of this work was to identify characteristic changes in

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Manoylova, I. K. "Damage to the organ of vision in chronic intoxication with trinitrotoluene." Kazan medical journal 50, no. 4 (2022): 91–93. http://dx.doi.org/10.17816/kazmj103950.

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Numerous studies indicate that with the chronic effect of trinitrotoluene (TNT, TNT) on the human body, peculiar specific opacities appear in the lens [1, 2, 3, 4, 5, 6, 7, 10 Despite the accumulated material on the clinic of trotyl cataract, the change in the organ of vision as a whole during poisoning with trinitrotoluene has not been studied enough. There is no unified classification of opacities in the lens, the issue of the pathogenesis of toxic cataracts has not been finally resolved, insufficient attention is paid to changes in other parts of the eye when exposed to TNT. Only in some wo

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Metlyaeva, N. A., A. Yu Bushmanov, I. A. Galstyan, et al. "Toxic Pneumosclerosis as a Consequence of Chronic Plutonium Exposure." MEDICAL RADIOLOGY AND RADIATION SAFETY 68, no. 1 (2023): 41–47. http://dx.doi.org/10.33266/1024-6177-2023-68-1-41-47.

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Purpose: To assess toxic pneumosclerosis caused by inhalation intake of plutonium aerosols in a patient who worked in contact with plutonium at the Mayak Production Association from 1948–1954. Material and methods: Patient Sh., born in 1924, higher education, at the age of 24, began working as a chemical engineer at MPO Mayak from 1948 to 1954 under conditions of increased occupational hazard of ionizing radiation (exposure to gamma rays and ingestion of plutonium aerosols). During her work, she received 389, 624 R: (1950 ‒ 83, 57; 1951 ‒ 187, 29; 1952 ‒ 70, 24; 1953 ‒ 48, 14). Carrying pluton

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Yadykina, Tatyana K., Nadezhda N. Mikhailova, Maria S. Bugaeva, et al. "Problems of formation of the toxic hepatopathy forming in the conditions of chronic fluoride intoxication of the body." Hygiene and sanitation 100, no. 7 (2021): 693–99. http://dx.doi.org/10.47470/0016-9900-2021-100-7-693-699.

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Introduction. Aluminium production is characterized by the accumulation of impurities of various toxic and chemical compositions in the air of working areas, the predominant among which are fluoride compounds. The accumulation of fluorides in the body causes the development of osteoarticular and associated systemic pathology. The aim of the study was to evaluate the hygienic and medico-biological features of toxic liver damage in the conditions of chronic fluoride intoxication of the body. Material and methods. The hygienic working conditions of the workers of the primary professions in alumin

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Farias-Junior, Paulo Mecenas Alves, Francisco Bruno Teixeira, Nathalia Carolina Fernandes Fagundes, et al. "Chronic intoxication by methylmercury leads to oxidative damage and cell death in salivary glands of rats." Metallomics 9, no. 12 (2017): 1778–85. http://dx.doi.org/10.1039/c7mt00168a.

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Nicolson, Garth L. "Membrane Lipid Replacement—a functional approach to repairing cellular membranes, reducing symptoms, and restoring function." Functional Food Science 2, no. 8 (2022): 198. http://dx.doi.org/10.31989/ffs.v2i8.990.

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Abstract: Membrane Lipid Replacement (MLR) uses natural, protected membrane lipid supplements to safely replace damaged, oxidized lipids in cellular membranes in order to restore membrane function, decrease various symptoms and improve health. Membrane injury occurs in essentially all chronic and acute medical conditions as well as in normal aging and development. The repair of damaged cellular membranes, and the removal of impaired membrane lipids and other toxic molecules from cells, are essential to recovery and health. Clinical studies have demonstrated the advantages of MLR in restoring m

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Hoffmann, Stefanie, and Cordian Beyer. "A Fatal Alliance between Microglia, Inflammasomes, and Central Pain." International Journal of Molecular Sciences 21, no. 11 (2020): 3764. http://dx.doi.org/10.3390/ijms21113764.

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Microglia are the resident immune cells in the CNS, which survey the brain parenchyma for pathogens, initiate inflammatory responses, secrete inflammatory mediators, and phagocyte debris. Besides, they play a role in the regulation of brain ion homeostasis and in pruning synaptic contacts and thereby modulating neural networks. More recent work shows that microglia are embedded in brain response related to stress phenomena, the development of major depressive disorders, and pain-associated neural processing. The microglia phenotype varies between activated-toxic-neuroinflammatory to non-activa

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Ferrero, Maria Elena. "Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals." BioMed Research International 2016 (2016): 1–13. http://dx.doi.org/10.1155/2016/8274504.

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Exposure to environmental and occupational toxicants is responsible for adverse effects on human health. Chelation therapy is the only procedure able to remove toxic metals from human organs and tissue, aiming to treat damage related to acute and/or chronic intoxication. The present review focuses on the most recent evidence of the successful use of the chelating agent ethylenediaminetetraacetic acid (EDTA). Assessment of toxic-metal presence in humans, as well as the rationale of EDTA therapy in cardiovascular and neurodegenerative diseases, is reported.

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Pinto, Claudio, Elisabetta Ninfole, Antonio Benedetti, Marco Marzioni, and Luca Maroni. "Involvement of Autophagy in Ageing and Chronic Cholestatic Diseases." Cells 10, no. 10 (2021): 2772. http://dx.doi.org/10.3390/cells10102772.

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Autophagy is a “housekeeping” lysosomal degradation process involved in numerous physiological and pathological processes in all eukaryotic cells. The dysregulation of hepatic autophagy has been described in several conditions, from obesity to diabetes and cholestatic disease. We review the role of autophagy, focusing on age-related cholestatic diseases, and discuss its therapeutic potential and the molecular targets identified to date. The accumulation of toxic BAs is the main cause of cell damage in cholestasis patients. BAs and their receptor, FXR, have been implicated in the regulation of

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Hadrian, Krzysztof, and Adam Przybyłkowski. "Toxic milk mice models of Wilson’s disease." Molecular Biology Reports 48, no. 2 (2021): 1903–14. http://dx.doi.org/10.1007/s11033-021-06192-5.

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AbstractWilson’s disease (WD) is a rare genetic disorder inherited as an autosomal recessive trait. The signs and symptoms of this disease are related to dysfunctional ATP7B protein which leads to copper accumulation and cellular damage. The organs that are most commonly affected by WD are the liver and brain. The dysfunctional ATP7B homolog has previously been identified in many different species, including two naturally occurring murine models called toxic milk mice. The aim of this paper was to compare the toxic milk mouse described by Rauch (tx) to that from Jackson Laboratory (txJ) throug

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GABITOVA, N. KH, I. N. CHEREZOVA, and A. I. VASINA. "Toxic effects of chronic nicotine and alcohol intoxication on a newborn child." Practical medicine 21, no. 5 (2023): 86–90. http://dx.doi.org/10.32000/2072-1757-2023-5-86-90.

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Smoking tobacco and consumption of nicotine containing products are a serious medical, social and economic problem throughout the world, as is the consumption of alcoholic beverages. The habit of smoking often develops in adolescence, forming the main contingent of chronic smokers in the future. Smoking during pregnancy increases the risk of perinatal morbidity and mortality by 27%. Children born to smoking mothers are characterized by neonatal adaptation disorders, which become pathological when exposed to tobacco metabolites (nicotine, carbon monoxide, etc.). The most common forms of neonata

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35

Velichko, Valentyna, Halyna Cornovan, Svitlana Kovalenko, and Halyna Danilchuk. "Evaluation of the Effectiveness and Safety of Combination Therapy Using Drugs Vazonat and Entrop in Patients with Chronic Toxic Liver Damage." Family Medicine, no. 5 (December 30, 2016): 98–102. http://dx.doi.org/10.30841/2307-5112.5.2016.248795.

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The objective: to study the efficacy and safety of using in the complex treatment of cytoprotector Vazonat in combination with the nootropic medicine of entropy in patients with chronic toxic liver damage. Patients and methods. There were examined 60 patients (36 men and 24 women) with signs of liver toxicity in age from 35 to 63 years. The average age of the examined was 43.2±1.3 years. All patients were divided into two statistically homogeneous groups (main and control) for 30 people in each. Patients in both groups received diet therapy, hepatoprotective, according to indications – a

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36

Matrosova, L. E., V. O. Dombrovsky, S. A. Tanaseva, E. Yu Tarasova, O. K. Ermolaeva, and M. A. Erohondina. "Pharmacological correction of white rats liver damage in aflatoxin B1 poisoning." International Journal of Veterinary Medicine, no. 4 (January 29, 2023): 127–33. http://dx.doi.org/10.52419/issn2072-2419.2022.4.127.

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Aflatoxin B1 is a hepatotoxic and hepatocarcinogenic compound. It is one of the common mycotoxins that causes various pathological conditions in humans and animals such as acute and chronic liver damage, neurological disorders, neoplasms and reproductive disorders.The present work was aimed to study the preventive effect of a dietary supplement based on milk thistle flour, succinic acid, bentonite, probiotic strain B. subtilis, vitamins A and E in experimental aflatoxicosis of laboratory animals. The experiments were carried out on 24 white rats, divided according to the principle of analogues

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Korkmaz, Ahmet, Sukru Oter, Melik Seyrek, and Turgut Topal. "Molecular, genetic and epigenetic pathways of peroxynitrite-induced cellular toxicity." Interdisciplinary Toxicology 2, no. 4 (2009): 219–28. http://dx.doi.org/10.2478/v10102-009-0020-4.

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Molecular, genetic and epigenetic pathways of peroxynitrite-induced cellular toxicityOxidative stress plays a key role in the pathogenesis of cancer and many metabolic diseases; therefore, an effective antioxidant therapy would be of great importance in these circumstances. Nevertheless, convincing randomized clinical trials revealed that antioxidant supplementations were not associated with significant reduction in incidence of cancer, chronic diseases and all-cause mortality. As oxidation of essential molecules continues, it turns to nitro-oxidative stress because of the involvement of nitri

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Emelyanova, A. Yu, O. E. Zinovyeva, S. R. Fedoseev, and E. V. Misyuryaeva. "Neurological complications of alcoholic disease and ways of their correction." Neurology, Neuropsychiatry, Psychosomatics 11, no. 3 (2019): 124–28. http://dx.doi.org/10.14412/2074-2711-2019-3-124-128.

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The problem of alcohol abuse and its social and medical consequences has remained relevant for many years. Damage to the nervous system is one of the most common manifestations of alcoholic disease. The effect of ethanol and its metabolites results in damage to all parts of the nervous system and skeletal muscles. The paper provides a brief overview of Russian and foreign literature on the neurological manifestations of chronic alcohol intoxication. It considers modern ideas about the pathogenesis of alcoholic neuropathy (APN). It also discusses differences in the clinical presentation, course

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Saxena, Prasoon Kumar, Rosaline Mishra, Abhishek Bhardwaj, Moumita Barman, and Rahul Chaudhary. "A Conspectus: Hepatotoxicity Caused by Drug’s." Indian Journal of Pharmaceutical and Biological Research 6, no. 03 (2018): 55–59. http://dx.doi.org/10.30750/ijpbr.6.3.9.

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Liver is the principle organ for metabolism of various drugs, endotoxins. Hepatotoxicity is one of the reversible conditions. Drugs are an vital cause of liver injury. Drug-induced injury to the liver can mimic any form of acute or chronic liver disease. The action of cytochrome P450 can induce acute injury to liver, through which drug will break down into electrophiles or free radicals. These spontaneous metabolites can covalently bind to protein and unsaturated fatty acids or induce lipid peroxidation, respectively. The clinical presentation of liver damage may be either cytolytic or cholest

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Bante, Punam, Shikha Sethiya, Mangala Thakare, and Dr.Varsha Dhurvey. "The Imapact of Paracetamol on the Excretory System: A Review of Toxicity and Protective Strategies." International Journal of Scientific Research in Biological Sciences 12, no. 2 (2025): 32–40. https://doi.org/10.26438/ijsrbs.v12i2.674.

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Paracetamol, a painkiller and antipyretic, works well for pain and fever. But its availability and perceived safety puts us at risk of accidental overdose which can cause liver damage, kidney failure, and other side effects. Paracetamol works by inhibiting COX-2 enzymes, reducing prostaglandin production, and targeting the hypothalamus to relieve pain, inflammation, and fever. But overdose can cause severe kidney damage and impairment leading to acute and chronic renal dysfunction. Studies have shown that paracetamol administration can cause nephrotoxicity characterized by histopathological ch

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Meng, Zitong, Liangliang Wang, Yuxiao Liao, et al. "The Protective Effect of Heme Oxygenase-1 on Liver Injury Caused by DON-Induced Oxidative Stress and Cytotoxicity." Toxins 13, no. 10 (2021): 732. http://dx.doi.org/10.3390/toxins13100732.

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Deoxynivalenol (DON) is a kind of Fusarium toxin that can cause a variety of toxic effects. Oxidative stress and DNA damage play a critical role in the toxicity of DON. However, previous studies focused more on acute toxicity in vivo/vitro models and lacked subchronic toxicity study in vivo. The potentially harmful effect of DON given at doses comparable to the daily human consumption in target organs, especially the liver, which is the main detoxification organ of DON, is also still not fully understood. Otherwise, Heme Oxygenase-1 (HO-1) has also reduced cell damage under the DON condition a

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Lin, Tien-An, Victor Chien-Chia Wu, and Chao-Yung Wang. "Autophagy in Chronic Kidney Diseases." Cells 8, no. 1 (2019): 61. http://dx.doi.org/10.3390/cells8010061.

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Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis. In clinical studies, autophagy activations and inhibitions are linked to acute kidney injuries, chronic kidney diseases, diabetic nephropathies, and polycystic kidney diseases. Oxidative stress, inflammation, and mitochondrial dysfunction, which are implicated as important mechanisms underlying many kidney diseases, modulate the autophagy activation and inhibition and lead to cellul

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Aroniadou-Anderjaska, Vassiliki, Taiza H. Figueiredo, Marcio de Araujo Furtado, Volodymyr I. Pidoplichko, and Maria F. M. Braga. "Mechanisms of Organophosphate Toxicity and the Role of Acetylcholinesterase Inhibition." Toxics 11, no. 10 (2023): 866. http://dx.doi.org/10.3390/toxics11100866.

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Organophosphorus compounds (OPs) have applications in agriculture (e.g., pesticides), industry (e.g., flame retardants), and chemical warfare (nerve agents). In high doses or chronic exposure, they can be toxic or lethal. The primary mechanism, common among all OPs, that initiates their toxic effects is the inhibition of acetylcholinesterase. In acute OP exposure, the subsequent surge of acetylcholine in cholinergic synapses causes a peripheral cholinergic crisis and status epilepticus (SE), either of which can lead to death. If death is averted without effective seizure control, long-term bra

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Sh.O., Urazbayeva, V. F. Tukhtasheva, Saidov S.A., and Yakubov A.K. "Analysis of models for involving experimental liver poisoning in rats." American Journal Of Biomedical Science & Pharmaceutical Innovation 5, no. 2 (2025): 5–8. https://doi.org/10.37547/ajbspi/volume05issue02-02.

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In recent years, chronic liver diseases have become a significant cause of death and disability [2], there is a trend towards an increase in the number of patients with chronic liver disease. It is widespread mainly among people of working age [3], which is explained by the living conditions of modern humans and the presence of a large number of chemical compounds in the environment. This leads to changes in metabolic processes in the liver and its toxic damage. According to WHO data, over the past 20 years, there has been a trend towards an increase in the number of liver diseases leading to

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Gasser, Erin K., and Hildy M. Schell-Chaple. "Systemic Lupus Erythematosus and Critical Illness." AACN Advanced Critical Care 31, no. 3 (2020): 296–307. http://dx.doi.org/10.4037/aacnacc2020355.

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Systemic lupus erythematosus is a chronic autoimmune disorder that causes a wide range of mild to life-threatening conditions that require hospitalization and critical care. The morbidity and mortality of systemic lupus erythematosus are associated with the organ system damage caused by intermittent or chronic disease activity and with the complications of long-term and toxic immunosuppressant medication regimens. This article reviews the epidemiologic, clinical, diagnostic, and therapeutic information essential for critical care clinicians who provide care to patients with systemic lupus eryt

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Kondakov, I. I., I. I. Topchii, and O. M. Kirienko. "INFLUENCE OF GLICEROL ON FUNCTIONAL-MORPHOLOGICAL INDICATORS OF KIDNEYS AT MODELLING RENAL INSUFFICIENCY IN RATS." Ukrainian Journal of Nephrology and Dialysis, no. 3(39) (December 12, 2017): 14–20. http://dx.doi.org/10.31450/ukrjnd.3(39).2013.02.

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It is known, that after acute damage of kidney there is a risk of development of chronic kidney desease and death rate from its complications. Material and methods. Research are spent on 40 not purebred rats at modelling of acute damage of the kidneys caused by toxic doses of glycerol. To evaluate histopathologal changes , we used cuts of fabrics painted gematoksilin- eozinom. Ultrathin preparations analyzed in electronic microscope PЕМ-125К. Results. Administration of glycerol leads to uremia with dystrophic changes in tubular device and glomerular hypertrophy. At a stage of chron

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Cherdwongchareonsuk, Duangrudee, Artur P. Águas, Rui Henrique, Suchart Upatham, and Antonio Sousa Pereira. "Toxic effects of selenium inhalation: acute damage of the respiratory system of mice." Human & Experimental Toxicology 22, no. 10 (2003): 551–57. http://dx.doi.org/10.1191/0960327103ht396oa.

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Accidental inhalation of selenium by humans has been associated with damage of respiratory tissues that is lacking a detailed histological definition. We have investigated the natural history of injury to the tracheal epithelium and lungs induced by a single intratracheal instillation of CD-1 mice with two different doses of dimethyl selenide (0.05 and 0.1 mg Se/kg of body weight). The animals were sacrificed 1, 7, 14, and 28 days after the single selenium treatment. Samples of the trachea and lungs were studied by light microscopy. The tracheal epithelium showed loss of cilia and acute necros

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Gabbasova, Irina V., Valeria A. Sletova, Alina D. Oksentyuk, et al. "Diagnostic analysis of toxic damage due to a dose of zoledronic acid." Research Results in Pharmacology 10, no. 1 (2023): 45–51. http://dx.doi.org/10.18413/rrpharmacology.10.433.

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Introduction: Comprehensive analysis is necessary to analyze the widespread use of bisphosphonate drugs in the treatment and prevention of various diseases of connective tissue structures. The relevance of the study depends on the impact they have on the patient’s somatic condition, given the number of early and late complications diagnosed by domestic and foreign clinicians. Materials and methods: The methodology used was developed on Stavropol Regional Clinical Hospital from 2010 to 2022. A randomized and observational study of the state of connective tissue structures was conducted in

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NUHOĞLU, HİLMİ. "Chemically and pharmacologically induced liver toxicity models in experimental animals and observed changes." Rats 2, no. 2 (2024): 51–62. https://doi.org/10.5281/zenodo.14568604.

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Toxicity models conducted using laboratory animals are widely preferred in biomedical research to understand the effects of toxic substances on biological systems, to make safety assessments, and to test therapeutic approaches. Another reason is the physiological and anatomical similarities of mice, rats, and rabbits to humans. Although there are many experimental liver toxicity models, toxicity models created with drugs and chemicals are preferred over surgical models. These models aim to simulate many conditions such as acute or chronic toxicities, drug toxicities, hepatitis, steatosis, and

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Maddu, Narendra, and S. Fareeda Begum. "Review on Chronic Exposure of Acrylamide Causes a Neurotoxicity Risk." INNOSC Theranostics and Pharmacological Sciences 1, no. 1 (2018): 20–26. http://dx.doi.org/10.26689/itps.v1i1.416.

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The exposure and inhalation of acrylamide (ACR) are not safe to the human health leading to the potential neurotoxicity. ACR is widely used in biochemical techniques and highly occurs in processing foods such as potato chips prepared at high temperatures. ACR is formed from reducing sugars and asparagine through the Maillard reaction. It exerts various harmful and toxic effects such as neurotoxicity both in humans and animal studies. The extensive damage of synaptic proteins, the formation of ACR-DNA adducts, degeneration of motor neurons, neurofilament reduction, are the most common neurologi

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