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1

Shiffman, Mitchell L., ed. Chronic Hepatitis C Virus. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-1192-5.

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2

1944-, Gerlich W. H., ed. Research in chronic viral hepatitis. Springer-Verlag, 1993.

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3

Green, William Finley. The first year-- hepatitis B: An essential guide for the newly diagnosed. Marlowe & Co., 2002.

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4

Husereau, Donald Robert. Interferon-based therapies for chronic hepatitis C virus infection: An assessment of clinical outcomes. Canadian Coordinating Office for Health Technology Assessment, 2004.

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5

Bruce, Brady, and Canadian Agency for Drugs and Technologies in Health., eds. Pegylated interferon combined with ribavirin for chronic hepatitis c virus infection: An economic evaluation. Canadian Agency for Drugs and Technologies in Health, 2007.

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6

Lindh, Gudrun. Chronic hepatitis B: Impact of hepatitis D virus superinfection and the hepatitis B e-system on histological outcome, and correlation of the hepatitis B e-system to HBV-DNA in serum. Distributed by the Almqvist & Wiksell Periodical Co., 1986.

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7

institutet, Karolinska, ed. Chronic hepatitis B: Impact of hepatitis D virus superinfection and the hepatitis B e-system on histological outcome, and correlation of the hepatitis B e-system to HBV-DNA in serum. Distributed by Almqvist & Wiksell Periodical Co., 1986.

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8

Chronic Hepatitis B. W.B. Saunders Company, 2010.

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9

Kourtis, Athena P., Shruti Chandramouli, Gonzague Jourdain, and Marc Bulterys. Hepatitis B Virus. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190604813.003.0004.

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Hepatitis B virus (HBV) is the most common cause of chronic viral hepatitis and hepatocellular carcinoma in the world. Worldwide, more than 250 million people are chronically infected with HBV, causing nearly 780,000 deaths each year, and mother-to-child transmission (MTCT) accounts for more than one-third of chronic HBV infections. Universal vaccination in neonates is the most effective strategy for eliminating infections worldwide. Maternal antiviral treatment during the antepartum/postpartum period for mothers with high HBV viral loads is effective in preventing HBV MTCT. Full immunization
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10

Honegger, Jonathan R. Hepatitis C Virus. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190604813.003.0005.

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An estimated 185 million individuals have been infected with hepatitis C virus (HCV) worldwide. Although often clinically silent for decades, chronic HCV infection predisposes to late-onset complications, including liver cirrhosis and hepatocellular carcinoma. Mother-to-child transmission (MTCT) of HCV affects approximately 5% of children born to viremic mothers and is the primary route of HCV infection in young children. While some vertically acquired HCV infections are resolved during the first years of life, many persist indefinitely. Chronically infected children tend to be asymptomatic an
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11

Wilson, Deanna. Hepatitis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0035.

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Hepatitis A (HAV) and E (HEV) viruses are spread via the fecal-oral route. Hepatitis B virus (HBV) exposure is via occupational or recreational activities. Hepatitis D virus (HDV; also spread parentally) can only coinfect or superinfect those with chronic HBV. Hepatitis C (HCV) transmission is predominantly parenteral; the highest risk group is injection drug users. Prodromal-period patients with acute hepatitis present with vague constitutional symptoms when serum transaminases peak, with elevated serum bilirubin and varying levels of hepatic protein synthesis impairment; during the icteric p
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12

Chronic Viral Hepatitis: Diagnosis and Therapeutics. Humana, 2012.

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13

Wu, George Y., Kirti Shetty, and Raymond S. Koff. Chronic Viral Hepatitis: Diagnosis and Therapeutics. Humana Press, 2001.

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14

Ning, Qin. Acute Exacerbation of Chronic Hepatitis B: Volume 2. Diagnosis and Management. Springer, 2019.

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15

Beattie, R. Mark, Anil Dhawan, and John W.L. Puntis. Hepatitis B. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569862.003.0057.

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Epidemiology 418Transmission 418Clinical features 418Interpretation of HBV serology 419Complications 419Prevention 421Management of chronic HBV infection 422• About 2 billion people (1/3 of the world population) show evidence of exposure to hepatitis B virus (HBV) infection, with 300–400 million showing evidence of chronic HBV infection....
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16

Shiffman, Mitchell L. Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future. Springer, 2011.

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17

Ning, Qin. Acute Exacerbation of Chronic Hepatitis B: Volume 1. Definition, Research Technology, Virology, Genetics and Immunology. Springer, 2019.

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18

Ning, Qin. Acute Exacerbation of Chronic Hepatitis B: Volume 1. Definition, Research Technology, Virology, Genetics and Immunology. Springer, 2019.

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19

Keshav, Satish, and Palak Trivedi. Viral hepatitis. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0212.

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Hepatitis means ‘inflammation of the liver’ and is manifest with symptoms that include malaise, anorexia, fever, flu-like symptoms, and pain in the right upper quadrant of the abdomen, with the pain being caused by swelling of the liver and its capsule. Elevations in circulating hepatic enzymes, particularly aspartate transaminase and alanine transaminase, are common, with jaundice occurring some time after the onset of other symptoms and signs. There are five viruses that primarily cause viral hepatitis: hepatitis A, B, C, D, and E viruses, abbreviated HAV, HBV, HCV, HDV, and HEV, respectivel
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20

Van Calsteren, Kristel. Chronic maternal infections. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198713333.003.0050.

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Pregnant women diagnosed with chronic infections are a worldwide problem. In developed countries, the most frequently encountered are hepatitis B and C, toxoplasmosis, syphilis, herpes simplex, and Cytomegalovirus infections. In developing countries, human immunodeficiency virus and malaria are also seen commonly in pregnant women. Maternal infections are associated with various complications in pregnant women, but also with congenital infections with or without structural anomalies and long-term sequelae, fetal growth restriction, preterm delivery, and perinatal mortality. Moreover, increasin
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21

Chronic Hepatitis C Virus Advances In Treatment Promise For The Future. Springer, 2011.

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22

Barnett, Ben J., and Margaret Hoffman-Terry. HIV/Hepatitis Co-infection. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0039.

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Hepatitis B virus (HBV) infection is common in people living with HIV, and all patients with HIV should be screened for HBV infection. The most common route of transmission worldwide is through perinatal or early childhood exposure, but adult transmission of HBV is often by routes similar to those for HIV, including sexual contact and injection drug use. Although it varies by exposure route, approximately 10% of HIV-positive patients also have chronic HBV infection, and up to 90% have serologic evidence of past exposure to HBV. Long-term complications of HBV infection can include cirrhosis, en
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23

Price, Jennifer Cohen, Priyanka Amin, and Antoine Douaihy. Hepatitis C and HIV Co-Infection. Edited by Mary Ann Cohen, Jack M. Gorman, Jeffrey M. Jacobson, Paul Volberding, and Scott Letendre. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199392742.003.0043.

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Chronic infection with hepatitis C virus (HCV) is a leading cause of end-stage liver disease and is the most common indication for liver transplantation in the United States. Because of shared risk factors, individuals living with HIV infection are disproportionately affected by HCV. Moreover, co-infection with HIV accelerates the natural history of chronic HCV infection, increasing the risk of cirrhosis, hepatocellular carcinoma, hepatic decompensation, and death. Highly effective medications such as direct-acting antivirals (DAA) to cure HCV are now available and have the potential to profou
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24

Franceschi, Silvia, Hashem B. El-Serag, David Forman, Robert Newton, and Martyn Plummer. Infectious Agents. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0024.

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Eleven infectious agents (seven viruses, three parasites, and one bacterium) have been classified by the International Agency for Research on Cancer as carcinogenic to humans for one or more cancer sites: hepatitis B virus; hepatitis C virus; thirteen types of human papillomavirus (HPV); human immunodeficiency virus type 1 (HIV-1); human T-cell leukemia virus type 1; Epstein-Barr virus; Kaposi sarcoma herpesvirus; Helicobacter pylori; Opisthorchis viverrini; Clonorchis sinensis; and Schistosoma haematobium. Other infectious agents, such as Merkel cell polyomavirus, Plasmodium falciparum, and c
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25

Thomas London, W., Jessica L. Petrick, and Katherine A. McGlynn. Liver Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0033.

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Primary liver cancer is the sixth most frequently occurring cancer in the world and the second most common in terms of cancer deaths. The global burden of liver cancer is borne principally by countries in East Asia and Africa, where 80% of liver cancer arises. Incidence rates of liver cancer, however, have begun to decline in Asia, while rates are increasing in low-rate areas such as Europe and North America. The dominant histology of liver cancer in almost all countries is hepatocellular carcinoma (HCC). The major risk factors for HCC—chronic infection with either hepatitis B virus (HBV) or h
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26

Proceedings of an International Symposium on Anti-Viral Agents in Chronic Hepatitis B Virus Infection. Elsevier Science & Technology, 1986.

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27

Cooke, Graham. Viral infection. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0308.

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Viral infection includes any clinical illness caused by a pathogenic virus. Acute viral infections are amongst the most common illnesses of humans and range from minor upper respiratory tract infections to viral haemorrhagic fever. The principles in diagnosing acute viral infection are, first, recognize the syndrome, then identify key features that might suggest a specific diagnosis, and, finally, consider laboratory investigations to elucidate the specific causative agent. The host–pathogen response determines different outcomes for specific viral infections. After infection with some viruses
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28

MD, Mitchell L. Shiffman. Challenging Issues in the Management of Chronic Hepatitis B Virus, An Issue of Clinics in Liver Disease. Elsevier, 2021.

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29

Thun, Michael J., Christopher P. Wild, and Graham Colditz. Framework for Understanding Cancer Prevention. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0061.

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The worldwide increase in the number of people affected by cancer and the costs of cancer care has increased the urgency of efforts to translate knowledge about the causes of cancer into effective preventive interventions. A wide range of interventions has proven to be effective for cancer prevention, either by reducing exposure to known causes of human cancer or by disrupting the multistage progression of tumors. Examples of progress include the up to 40% decrease in the age-standardized lung cancer incidence rate among men in high- and middle-income countries due to tobacco control; the 30%
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30

Thun, Michael J., Martha S. Linet, James R. Cerhan, Christopher Haiman, and David Schottenfeld. Primary Prevention of Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0062.

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Primary prevention has enormous potential to reduce the human, social, and economic costs of cancer worldwide. The following sections discuss the development and application of preventive interventions in six broad areas of public health: tobacco control, the prevention of obesity and physical inactivity, prevention of infection-related cancers, protection against excessive exposure to ultraviolet light, preventive drug therapies (chemoprevention), and the regulation of carcinogenic exposures. All of these areas affect multiple types of cancer and massive numbers of people. Different intervent
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