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Journal articles on the topic 'Chronomodulated drug delivery system'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Arora, Shilpi, and Sonia Dhiman. "Formulation Development and Evaluation of Chronomodulated Drug Delivery Systems for treatment of Diabetes." Journal of Neonatal Surgery 14, no. 19S (2025): 381–93. https://doi.org/10.63682/jns.v14i19s.4772.

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The research focuses on the formulation development and evaluation of chronomodulated drug delivery systems for anti diabetic drugs, leveraging insights from past studies to optimize the delivery of Vildagliptin microspheres. Chronomodulated drug delivery systems are designed to synchronize the release of medication with the body's natural biological rhythms, enhancing therapeutic efficacy and patient compliance. Vildagliptin microspheres were meticulously prepared using an emulsion solvent evaporation method, guided by previous findings on drug-polymer ratios, surfactant concentrations, and s

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2

Alekya, Thota, Dudhipala Narendar, Donthi Mahipal, Narala Arjun, and Banala Nagaraj. "Design and Evaluation of Chronomodulated Drug Delivery of Tramadol Hydrochloride." Drug Research 68, no. 03 (2017): 174–80. http://dx.doi.org/10.1055/s-0043-119072.

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AbstractRheumatoid arthritis is an auto immune disease which requires chronotherapy as it occurs during early morning. Tramadol hydrochloride (TH) is an analgesic drug, used to treat rheumatoid arthritis. The aim of the present investigation was to develop chronomodulated drug delivery system of tramadol hydrochloride such that it releases the drug early in the morning, during which the symptoms of rheumatoid arthritis worsen. To develop chronomodulated drug delivery system of TH, initially core tablets of TH were prepared using three different supradisintegrants followed by coating with pH de

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3

P, Mahalakshmi, Suriyaprakash T N K, and S. Lakshmana Prabu. "Chronomodulated Delivery of Pantoprazole for Nocturnal Hyperacidity." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 4 (2015): 3038–44. http://dx.doi.org/10.37285/ijpsn.2015.8.4.7.

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The objective of this work was to design and evaluate an oral site-specific, pulsatile drug delivery system containing Pantoprazole sodium which can be targeted to colon in a pH and time dependent manner, to modulate the drug level in synchrony with the circadian rhythm of nocturnal hyperacidity. Five different composition of Core tablets were prepared by direct compression technique. Based on the release studies of core tablets, nine different compositions of press coated tablets were prepared and analyzed. The press coated tablet further coated by using five different proportions of Eudragit

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4

V, Ravali, and P. Balaji. "Pulsatile Drug Delivery Systems: A Comprehensive Review." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 01 (2024): 463–71. http://dx.doi.org/10.25258/ijddt.14.1.65.

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sigmoidal drug release profile is formed when a pulsatile drug delivery system (PDDI) initiates drug administration and follows it up with rapid and complete drug release. It ensures the correct dosage of the drug is delivered at the right time and place. Pulsatile drug delivery is effective for treating asthma, arthritis, cancer, diabetes, epilepsy, hypertension, ulcers, and hypercholesterolemia, among others. There are many types of delivery systems in the pharmaceutical industry, including capsular, osmotic, single and multi-unit designs and membranes that are soluble and erodible. Innovati

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Patil, ArchanaS, VinayakS Masthiholimath, BasavarajK Najwade, PanchaxariM Dandagi, and AnandP Gadad. "Development and characterization of chronomodulated drug delivery system of captopril." International Journal of Pharmaceutical Investigation 1, no. 4 (2011): 227. http://dx.doi.org/10.4103/2230-973x.93010.

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6

Amitha, Shetty 1. *. Panneer Selvam 2. Maya Sharma 3. Smitha Shetty 4. "FORMULATION AND EVALUATION OF CHRONOMODULATED DRUG DELIVERY SYSTEM CONTAINING CAPTOPRIL AND HYDROCHLOROTHIAZIDE." Journal of Pharma Research 8, no. 7 (2019): 468–77. https://doi.org/10.5281/zenodo.3357189.

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<strong><em>ABSTRACT</em></strong> <strong><em>B</em></strong><em>lood pressures displays circadian rhythm. The objective of present study was to develop chronomodulated drug delivery system containing Captopril and Hydrochlorothiazide to achieve extended retention in upper gastro intestinal tract to enhance absorption and bioavailability. Captopril mucoadhesive microspheres were prepared by emulsification method using sodium alginate and guar gum polymers whereas Hydrochlorothiazide floating microspheres were prepared by non-aqueous solvent evaporation method using ethyl cellulose and hydroxy

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7

Raghavender, Chenna 1. *. Y. Padmanabha Reddy 2. "FORMULATION AND EVALUATION OF CHRONOMODULATED DRUG DELIVERY OF NIMODIPINE." Journal of Pharma Research 7, no. 12 (2018): 305–13. https://doi.org/10.5281/zenodo.2616666.

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<strong><em>ABSTRACT</em></strong>   <strong><em>T</em></strong><em>he objective of this study was to design and developed a rupturable coating type of pulsatile press coated tablet, which releases drug early in the morning hours. This delivery system was helpful to control an early morning surge in Blood Pressure because cardiovascular events occur more frequently in the morning. This delivery system would be useful for the prevention of cardiovascular events in hypertensive patients. Initially core tablet was prepared by using Nimodipine as a drug, and different concentration of cross c

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8

Sokar, M., A. Hanafy, A. Elkamel, and S. El-gamal. "Design of chronomodulated drug delivery system of valsartan: in vitro characterization." Indian Journal of Pharmaceutical Sciences 77, no. 4 (2015): 470. http://dx.doi.org/10.4103/0250-474x.164768.

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9

Chaudhary, SonaS, PunitB Parejiya, HetalK Patel, and PragnaK Shelat. "Chronomodulated drug delivery system of urapidil for the treatment of hypertension." International Journal of Pharmaceutical Investigation 5, no. 2 (2015): 107. http://dx.doi.org/10.4103/2230-973x.153389.

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10

Ali, J., J. Qureshi, Mohd Amir, Alka Ahuja, and Sanjula Baboota. "Chronomodulated drug delivery system of salbutamol sulphate for the treatment of nocturnal asthma." Indian Journal of Pharmaceutical Sciences 70, no. 3 (2008): 351. http://dx.doi.org/10.4103/0250-474x.43000.

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11

Lévi, Francis, Atilla Altinok, Jean Clairambault, and Albert Goldbeter. "Implications of circadian clocks for the rhythmic delivery of cancer therapeutics." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 366, no. 1880 (2008): 3575–98. http://dx.doi.org/10.1098/rsta.2008.0114.

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The circadian timing system (CTS) controls drug metabolism and cellular proliferation over the 24 hour day through molecular clocks in each cell. These cellular clocks are coordinated by a hypothalamic pacemaker, the suprachiasmatic nuclei, that generates or controls circadian physiology. The CTS plays a role in cancer processes and their treatments through the downregulation of malignant growth and the generation of large and predictable 24 hour changes in toxicity and efficacy of anti-cancer drugs. The tight interactions between circadian clocks, cell division cycle and pharmacology pathways

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12

Parmar, Komal, Almas Shaikh, and Hitesh Dalvadi. "Chronomodulated drug delivery system of Irbesartan: Formulation and development using Desing of Experiment (DoE)." Bulletin of Faculty of Pharmacy, Cairo University 56, no. 1 (2018): 11–17. http://dx.doi.org/10.1016/j.bfopcu.2017.11.004.

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13

Bichewar, Shubhangi, Sujit Pillai, Rampal Singh Mandloi, Nikhlesh Birla, and Sanket Jain. "Formulation and evaluation of chronomodulated drug delivery system of doxofylline for treatment of nocturnal asthma." RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY 13, no. 12 (2020): 6170–75. http://dx.doi.org/10.5958/0974-360x.2020.01076.8.

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14

Qureshi, M. J., J. Ali, S. Baboota, A. Ahuja, and C. Mallikarjun. "Pharmacokinetic Study of a Capsule-based Chronomodulated Drug Delivery System of Salbutamol Sulphate in Rabbits." Tropical Journal of Pharmaceutical Research 13, no. 1 (2014): 17. http://dx.doi.org/10.4314/tjpr.v13i1.

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15

Qureshi, M. J., J. Ali, S. Baboota, A. Ahuja, and C. Mallikarjun. "Pharmacokinetic Study of a Capsule-based Chronomodulated Drug Delivery System of Salbutamol Sulphate in Rabbits." Tropical Journal of Pharmaceutical Research 13, no. 1 (2014): 17. http://dx.doi.org/10.4314/tjpr.v13i1.3.

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16

Sowmya, Cherukuri, Vuppalapati Lavakumar, Narayanan Venkateshan, et al. "Microcapsule-based chronomodulated drug delivery systems of montelukast sodium in the treatment of nocturnal asthma." International Journal of Pharmaceutical Investigation 8, no. 1 (2018): 24. http://dx.doi.org/10.4103/jphi.jphi_101_17.

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17

Bisht, Rohit. "Chronomodulated drug delivery system: A comprehensive review on the recent advances in a new sub-discipline of ′chronopharmaceutics′." Asian Journal of Pharmaceutics 5, no. 1 (2011): 1. http://dx.doi.org/10.4103/0973-8398.80057.

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18

Beg, Sarwar, Suryakanta Swain, Sachin Gahoi, and Kanchan Kohli. "Design, Development and Evaluation of Chronomodulated Drug Delivery Systems of Amoxicillin Trihydrate with Enhanced Antimicrobial Activity." Current Drug Delivery 10, no. 2 (2013): 174–87. http://dx.doi.org/10.2174/1567201811310020004.

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19

Voleti, Vijaya Kumar, Ismail Yusuff, Mohamed Jalaludeen Abdulkadhar, and Mohammad Khalid Al-Sadoon. "Computational Simulation Study-Based Formulation Development and Characterization of MethylprednisoloneLoaded Nanoparticles Containing Chitosan and Pectin to Treat Nocturnal Asthma." Polymers 17, no. 1 (2024): 24. https://doi.org/10.3390/polym17010024.

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Nocturnal asthma (NA) is a high-prevalence disease that causes severe respiratory issues, leading to death from early midnight to early morning. In this research, nanoparticulate drug delivery system of methylprednisolone (MP) was developed using chitosan (CH) and pectin (PEC). MP is a synthetic corticosteroid medication widely used for its potent anti-inflammatory activity. Computational simulation study (AI-based blend analysis algorithm) was used to identify a better-mixing polymer with MP. MP nanoparticles were formulated by the ionic gelation method with the combination of CH and PEC. To

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20

Scully, Christopher G., Abdoulaye Karaboué, Wei-Min Liu, et al. "Skin surface temperature rhythms as potential circadian biomarkers for personalized chronotherapeutics in cancer patients." Interface Focus 1, no. 1 (2010): 48–60. http://dx.doi.org/10.1098/rsfs.2010.0012.

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Chronotherapeutics involve the administration of treatments according to circadian rhythms. Circadian timing of anti-cancer medications has been shown to improve treatment tolerability up to fivefold and double efficacy in experimental and clinical studies. However, the physiological and the molecular components of the circadian timing system (CTS), as well as gender, critically affect the success of a standardized chronotherapeutic schedule. In addition, a wrongly timed therapy or an excessive drug dose disrupts the CTS. Therefore, a non-invasive approach to accurately detect and monitor circ

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21

Dineshmohan, S., V. R. M. Gupta, A. Ramesh, V. Harika, and T. Sravani. "Effect of HPMC and ethyl cellulose polymeric granules and its combinations in press coated tablets of lornoxicam: fabrication and in vitro characterization." International Current Pharmaceutical Journal 4, no. 10 (2015): 447–52. http://dx.doi.org/10.3329/icpj.v4i10.24914.

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The main objective of the present exploration was to formulate and evaluate chronomodulated press-coated tablets to deliver the NSAID lornoxicam, when a pain in the joints, functional disability persist in the early morning time is typically observed in most Rheumatoid arthritis (RA) patients. Pre formulation studies and drug excipient compatibility studies were carried out for lornoxicam and excipients. Core tablets containing lornoxicam was prepared by direct compression method and the tablets were subjected to various pre-compression and post-compression parameters (C1-C4 formula) based on

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22

P. Uplanchiwar, Vaibhav, Koushik Narayan Sarma, Tabrej Mujawar, et al. "Chronotherapeutic Circadian-Based Pulsatile Drug Delivery of Etodolac for Morning Stiffness in Rheumatoid Arthritis." Journal of Neonatal Surgery 14, no. 4S (2025): 833–48. https://doi.org/10.52783/jns.v14.1879.

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This study focuses on the development of chronomodulated delivery systems for Etodolac, aimed at optimizing therapeutic outcomes in rheumatoid arthritis management. Core and coated microparticles were formulated using chitosan and Eudragit polymers, employing varying drug-to-polymer ratios and stirring speeds to achieve precise release profiles. Scanning electron microscopy confirmed the uniformity and integrity of the microparticles, with particle sizes ranging from 20.52 ± 0.79 µm to 105.45 ± 6.74 µm. Encapsulation efficiencies reached up to 98.34 ± 0.09% in coated formulations, demonstratin

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23

Raina, Binu, Pankaj sharma, Anurag Bhargava, Shailesh Sharma, and Abhimanyu Rai Sharma. "Design and development of chronomodulated pulsincap delivery system of deflazacort." Asian Pacific Journal of Health Sciences 5, no. 4 (2018): 210–20. http://dx.doi.org/10.21276/apjhs.2018.5.4.32.

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24

Agarwal, Vaibhav, and Mayank Bansal. "Chronomodulated Delivery System: a Tailored Cap to Fit Different Heads." Recent Patents on Drug Delivery & Formulation 6, no. 2 (2012): 171–80. http://dx.doi.org/10.2174/187221112800672930.

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25

Ankit Kumar and Sanjeev Kumar. "Intra Vaginal Drug Delivery System (Novel Drug Delivery System)." International Journal for Research in Applied Sciences and Biotechnology 7, no. 6 (2020): 234–41. http://dx.doi.org/10.31033/ijrasb.7.6.33.

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In case of intra-vaginal route of drug administration the dosage form is applied vaginally for the convenient release of the dosage form and for better therapeutic action of the medicament, it is usually used in HIV patients. many conditions that affect the female reproductive tract, such as , sexually transmitted diseases, fungal & bacterial infections, cancer and various pathogens such as virus (human immunodeficiency virus, HIV), bacteria (Gardnerella vaginalis), fungi (Candida spp.) or parasites (Trichomonas vaginalis). Systemically active drugs (contraceptive steroids) as well as loca

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26

Bhowmik, Debjit, K. P. Sampath Kumar, and Lokesh Deb. "Buccal Drug Delivery System-A Novel Drug Delivery System." Research Journal of Science and Technology 8, no. 2 (2016): 90. http://dx.doi.org/10.5958/2349-2988.2016.00012.7.

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27

SAKURAI, Y. "Drug Delivery System." JAPANES JOURNAL OF MEDICAL INSTRUMENTATION 63, no. 11 (1993): 507–10. http://dx.doi.org/10.4286/ikakikaigaku.63.11_507.

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28

TAKADA, Kanji. "Drug Delivery System." Kagaku To Seibutsu 42, no. 10 (2004): 644–50. http://dx.doi.org/10.1271/kagakutoseibutsu1962.42.644.

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29

Somberg, John C. "Drug Delivery System." Journal of Clinical Pharmacology 29, no. 8 (1989): 673. http://dx.doi.org/10.1002/j.1552-4604.1989.tb03400.x.

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30

Meghana, Raykar, and Shinde Ramesh. "SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM: A LIPID BASED DRUG DELIVERY SYSTEM." INTERNATIONAL JOURNAL OF CURRENT RESEARCH AND INNOVATIONS IN PHARMA SCIENCES 1, no. 1 (2022): 16–21. https://doi.org/10.5281/zenodo.8017592.

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31

Jayprakash, Khandelwal Mohit, Agrawal Dilip, and Goyal Rakesh. "COLON TARGETED DRUG DELIVERY SYSTEM ADVANCE IN NOVEL DRUG DELIVERY SYSTEM." International Journal of Current Pharmaceutical Review and Research 14, no. 03 (2022): 118–23. https://doi.org/10.5281/zenodo.12658882.

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The oral route is considered to be the most preferred route for administration of drugs forsystemic effect, but the oral route is not suitable to the administration of drug for lowergastrointestinal (GI) diseases, this happened due to their release at upper GI tract (stomach,small intestine), which further minimizes the accessibility of drugs at the lower GI tract. Toovercome this difficulty, colon-specific drug delivery systems have been broadly analyzedduring the last two decades. Oral delivery of drugs to the colon is valuable in the treatment ofdiseases of colon (ulcerative colitis, Chron'

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32

Fujiwara, Masahiro. "Drug Delivery System : DDS." Nippon Shokuhin Kagaku Kogaku Kaishi 57, no. 9 (2010): 400. http://dx.doi.org/10.3136/nskkk.57.400.

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33

&NA;. "Copolymer drug delivery system." Inpharma Weekly &NA;, no. 1106 (1997): 9. http://dx.doi.org/10.2165/00128413-199711060-00018.

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34

Rathi, JC, S. Tamizharasi, and V. Rathi. "Floating drug delivery system." Systematic Reviews in Pharmacy 2, no. 1 (2011): 19. http://dx.doi.org/10.4103/0975-8453.83435.

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35

Sivalingan, Giridharan, Ganesh GNK, and Mithra Chandrasekaran. "Multiparticulate Drug Delivery System." Research Journal of Pharmacy and Technology 13, no. 7 (2020): 3501. http://dx.doi.org/10.5958/0974-360x.2020.00620.4.

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36

Thakur, Sanjay, Krishnappa Ramya, Deepak Kumar Shah, and Khadga Raj. "Floating Drug Delivery System." Journal of Drug Delivery and Therapeutics 11, no. 3-S (2021): 125–30. http://dx.doi.org/10.22270/jddt.v11i3-s.4828.

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Floating drug delivery system (FDDS) helps to improve the buoyancy property of the drug over the gastric fluids and hence maintain the longer duration of action. It is helpful in minimizing the dosing frequency. The density of dosage form must be less than the density of gastric contents (1.004 gm/ml) in FDDS. It may effervescent or non-effervescent system. The drugs having narrow absorption window in GIT is good candidate for the floating drug delivery system. The main objective of writing this review article is to compile the recent literature with special focus on classification, method of

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37

Belgamwar, VeenaS, MadhuriV Gaikwad, GaneshB Patil, and Sanjay Surana. "Pulsatile drug delivery system." Asian Journal of Pharmaceutics 2, no. 3 (2008): 141. http://dx.doi.org/10.4103/0973-8398.43297.

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38

heir, Mandeep Kaur, and Sachin Sharma. "Transdermal Drug Delivery System." Indo Global Journal of Pharmaceutical Sciences 09, no. 02 (2019): 155. http://dx.doi.org/10.35652/igjps.2019.92s53.

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39

Yamahara, Hiroshi. "Transdermal Drug Delivery System." MEMBRANE 31, no. 1 (2006): 40–41. http://dx.doi.org/10.5360/membrane.31.40.

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40

Goud, M. Sharath Chandra, and V. P. Pandey. "GASTRORETENTIVE DRUG DELIVERY SYSTEM." International Journal of Pharmacy and Biological Sciences 6, no. 3 (2016): 158–65. http://dx.doi.org/10.21276/ijpbs.2016.6.3.19.

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41

McHugh, Jessica. "Promising drug delivery system." Nature Reviews Rheumatology 15, no. 2 (2019): 64. http://dx.doi.org/10.1038/s41584-019-0158-1.

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42

Dhamore, Harshada Gorakh, Assist Prof Kalpana S. Kale, and Dr Megha Salve. "Liposomal Drug Delivery System." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 502–9. https://doi.org/10.35629/4494-0906502509.

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Liposomes have been considered promising and versatile drug vesicles. Compared with traditional drug delivery systems, liposomes exhibit better properties, including site-targeting, sustained or controlled release, protection of drugs from degradation and clearance, superior therapeutic effects, and lower toxic side effects. Given these merits, several liposomal drug products have been successfully approved and used in clinics over the last couple of decades. In this review, the liposomal drug products approved by the U.S. Food and Drug Administration (FDA) and European Medicines. Agency (EMA)

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43

Swetha, Dr M., Makka Vandana, Mandugula Shiva Nandini, and Manumari Vaishnavi. "Implantable Drug Delivery System." International Journal of Multidisciplinary Research and Growth Evaluation 6, no. 1 (2025): 1578–82. https://doi.org/10.54660/.ijmrge.2025.6.1.1578-1582.

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Implantable drug delivery systems [IDDS] provide a viable substitute for conventional medication delivery techniques. The most popular medication delivery methods, oral and injectable, frequently cause blood drug concentrations to peak and then fall. This calls for ongoing administration in order to sustain therapeutic medication levels. Oral medication distribution also has to contend with issues such first-pass metabolism and drug degradation in the gastrointestinal system. Conversely, IDDS allow for prolonged medication release, which makes them particularly useful for treating chronic illn

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44

Kim, Jin-Seok. "Liposomal drug delivery system." Journal of Pharmaceutical Investigation 46, no. 4 (2016): 387–92. http://dx.doi.org/10.1007/s40005-016-0260-1.

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Suryawanshi, Dr Amrata D. "Transdermal Drug Delivery System." International Journal for Research in Applied Science and Engineering Technology 11, no. 10 (2023): 858–62. http://dx.doi.org/10.22214/ijraset.2023.56109.

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Abstract: A various non-invasive administration have recently emerged as an alternative toconventional needles. Transdermal drug delivery system is most attractive method. The transdermal as route has numerous advantages over the more traditional drug delivery system and they include high bioavailability, absence offirst pass hepatic metabolism, steady drug plasma concentration. and the fact that therapy is noninvasive. TDDS could be applicable in not only Pharmaceuticals but also in the skin industry, including cosmetics. Transdermal drug delivery has made an important contribution to medical

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M Shabbir, M. Sohil, Shaikh Imran Kalam, Dr G. J. Khan, Shaikh Md Moiz, and Shaikh Aman. "Targeted Drug Delivery System." International Journal of Research in Pharmacy and Allied Science 04, no. 01 (2025): 01–19. https://doi.org/10.71431/ijrpas.2025.4101.

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Paul Ehrlich's idea of a "magic bullet" has evolved into Nano medicine. In order to circumvent the particular harmful effect of traditional drug distribution, targeted drug delivery reduces the amount of drug needed for therapeutic efficacy by delivering the drug moiety directly to the specified body location (organ, cellular, and subcellular level of specific tissue). The idea of a "magic bullet" was developed to achieve this aim, and after more than a century of research, scientists created a number of devices that are nanometers in size, which is known as "Nano medicine." Among the carrier

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47

Sayali, shankhapal* Vaishnavi pandav Rutuja jaiswal Sonali kalam. "Transdermal Drug Delivery System." International Journal of Pharmaceutical Sciences 2, no. 8 (2024): 3570–80. https://doi.org/10.5281/zenodo.13354827.

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Transdermal drug delivery systems, or TDDSs, are adhesive patches applied to the skin with a precise dosage that are then absorbed into the bloodstream. It is important to take into account the entire morphological, biophysical, and physicochemical aspects of the skin when delivering medicinal substances through the human skin for systemic effects. A transdermal patch offers a regulated release and continuous drug administration, which is advantageous over other forms of pharmaceutical delivery. It also avoids pulsed entry into the systemic circulation, which frequently results in undesirable

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48

Yogita, Pawar* Shubhangi doer Priti Kolte Nitin kale. "Implantable Drug Delivery System." International Journal of Pharmaceutical Sciences 2, no. 8 (2024): 3684–88. https://doi.org/10.5281/zenodo.13369182.

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Implantable drug delivery system [IDDs] in modern medicine may traced to Deans by and Parkes who in 1938. The oral route is popular and convenient means of drug delivery . with there advantage there is also challenges. many drug are not suitable for the oral route of administration such as insulin. this article gives an overview of classification of these drug delivery devices ;the mechanism of drug release ;the materials used for manufacture. Implants are small sterile solid masses consisting of highly purified drug made by compression or molding or extrusion. Implants are developed with a vi

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49

Shubhangi, Jadhav* Rekha Gunja varsha aher Sonali kalam. "Niosomal Drug Delivery System." International Journal of Pharmaceutical Sciences 2, no. 8 (2024): 3689–96. https://doi.org/10.5281/zenodo.13370938.

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Niosomes (NS) are nonionic surfactant-based vesicles that are biodegradable, nontoxic, and stable drug carrier systems. NS amphiphilic nature makes them effective for encapsulation of lipophilic and hydrophilic active pharmaceutical  ingredient . The method of manufacture, the kind and quantity of surfactant, the concentration of drugs, the concentration of cholesterol, the temperature, and the kind of hydration media can all have an impact on the qualities of NS. When it comes to enhancing patient compliance, lowering side effects, achieving sustained release characteristics, lowering do

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50

Patel, Arshiya Mustak* Quazi Majaz Gulam Javed Khan. "Nasal Drug Delivery System." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 803–27. https://doi.org/10.5281/zenodo.10853329.

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Nasal route is alternative to parenteral therapy and also useful for long term therapy. Nasal route is non invasive, widely used for the local treatment may also be used for systemic therapy as drug directly goes in systemic circulation. In this article an overview of intranasal drug delivery with its various aspects like factors affecting nasal absorption are discussed. The use of the nasal route for the delivery of challenging drugs such as small polar molecules, vaccines, hormones, peptides and proteins has created much interest in nowadays. Due to the high permeability, high vasculature, l

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