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Relevant bibliographies by topics / Chronopharmacological behaviour

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Journal articles

Academic literature on the topic 'Chronopharmacological behaviour'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Chronopharmacological behaviour"

1

Kapila, Arpita* Rambabu Sharma Agarwal Shweta. "PULSATILE DRUG DELIVERY SYSTEM: A MECHANISTIC UPDATE." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 3928–34. https://doi.org/10.5281/zenodo.1042593.

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Pulsatile drug delivery systems are the systems which deliver the drug according to the circadian rhythm of the body. The product follows a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Thus, these systems deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. Various capsular, osmotic, single and multiple unit systems that are modulated by soluble or erodible polymer coatings, rupturable membran

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2

Jiabi, Ouyang, Wang Xingli, Yang Mohui, Tan Yani, Zhang Zhen, and Li Sha. "Preparation and Drug Release Mechanism of Time Controlled Explosive Pulsatile Tablets with Ethylcellulose Coating." Journal of Pharmaceutical and Biomedical Sciences 10, no. 04 (2020): 81–90. https://doi.org/10.5281/zenodo.3903240.

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<em><strong>Core tip:</strong></em> The development of pharmacology in the decade revealed the biological rhythm of the occurrence and development of certain diseases, usually the circadian rhythm. Therefore, chronopharmacological drug delivery is of great significance in the prevention and treatment of diseases having onset rhythm inconvenient to take drug. An easy-to-prepared, time-controlled explosive metoprolol tartaric pulsatile tablet was developed in order to provide patients with timed therapy of effective blood drug concentration at the optimal time. The formulation and process were o

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3

Mohui, Yang, Wang Xingli, Ouyang Jiabi, Zhang Zhen, Tan Yani, and Li Sha. "Drug Release and Pharmacokinetics Behavior of a Simple Ethylcellulose Coating Pulsatile Tablet of Time-Controlled Explosive System." Journal of Pharmaceutical and Biomedical Sciences 10, no. 03 (2020): 57–64. https://doi.org/10.5281/zenodo.3903310.

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<em><strong>Core tip:</strong></em> The time rhythm of the human body is associated with the occurrence and development of many diseases. Kinds of diseases of particular onset biorhythm provided the room for the development of chronopharmacological drug delivery systems. Metoprolol tartrate (MT), a medicine commonly used for treatment of cardiovascular diseases in clinic, was selected as model drug to develop a time-controlled explosive pulsatile tablet. The prepared MT pulsatile tablets showed a drug release lag time of 7.10 h <em>in vitro</em> perfectly consistent with the absorption lag tim

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4

Philippova, E. V. "Chrono- and pharmacological sensitivity of the central nervous system to the action of certain psychotropic drugs against the background of chronic alcohol intoxication." Terapevt (General Physician), no. 8 (August 11, 2022): 29–34. http://dx.doi.org/10.33920/med-12-2208-04.

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The behavior of experimental animals under the influence of two drugs with psychotropic action and their combination against the background of chronic alcohol intoxication in a chronopharmacological experiment was studied. A decrease in the threshold of sensitivity to electrical irritation was revealed against the background of the use of a deprimating agent and an increase in these indicators when this drug was combined with an antioxylant. The pronounced adaptive effect of the antioxidant is evidenced by its desynchronizing effect on the behavioral reactions of laboratory animals for two day

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5

Philippova, E. V. "Chronopharmacological sensitivity of the central nervous system of the organism of experimental animals to the action of certain psychotropic drugs against the background of chronic alcohol intoxication." Terapevt (General Physician), no. 12 (December 17, 2020): 63–68. http://dx.doi.org/10.33920/med-12-2012-08.

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The behavior of experimental animals under the influence of two drugs with psychotropic action and their combination against the background of chronic alcohol intoxication in a chronopharmacological experiment was studied. A decrease in the threshold of sensitivity to electrical irritation was revealed against the background of the use of a deprimating agent and an increase in these indicators when this drug was combined with an antioxylant. The pronounced adaptive effect of the antioxidant is evidenced by its desyn chronizing effect on the behavioral reactions of laboratory animals for two da

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6

Rebuelto, M., L. Ambros, and M. Rubio. "Chronopharmacological Study of an Antimicrobial Agent, Norfloxacin, in the Rat." Biological Rhythm Research 34, no. 1 (2003): 51–60. http://dx.doi.org/10.1076/brhm.34.1.51.14085.

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7

Filippova, E. V. "Features of the sensitivity of the central nervous system of the organism of experimental animals to the effects of certain psychotropic drugs and their combinations against the background of chronic alcohol intoxication in a chronopharmacological experiment." Terapevt (General Physician), no. 12 (December 17, 2020): 56–62. http://dx.doi.org/10.33920/med-12-2012-07.

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In a chronopharmacological experiment, the effect of two drugs with psychotropic action in combinations on the behavior of laboratory animals subjected to chronic alcohol intoxication was examined. Against the background of a deprimating agent, a decrease in the threshold of sensitivity to electrical irritation and the duration of an aggressive reaction was revealed; an increase in these indicators was established with a combination of a deprimating drug with an antioxidant. It has been shown that the antioxidant has a desynchronizing effect on the behavioral reactions of laboratory animals fo

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8

Filippova, E. V. "Features of the sensitivity of the central nervous system of the organism of experimental animals to the effects of certain psychotropic drugs and their combinations against the background of chronic alcohol intoxication in a chronopharmacological experiment." Terapevt (General Physician), no. 12 (December 17, 2020): 56–62. http://dx.doi.org/10.33920/10.33920/med-12-2012-07.

Full text

Abstract:

In a chronopharmacological experiment, the effect of two drugs with psychotropic action in combinations on the behavior of laboratory animals subjected to chronic alcohol intoxication was examined. Against the background of a deprimating agent, a decrease in the threshold of sensitivity to electrical irritation and the duration of an aggressive reaction was revealed; an increase in these indicators was established with a combination of a deprimating drug with an antioxidant. It has been shown that the antioxidant has a desynchronizing effect on the behavioral reactions of laboratory animals fo

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9

Parmar, Ramesh D., Rajesh K. Parikh, G. Vidyasagar, Dhaval V. Patel, Chirag J. Patel, and Biraju D. Patel. "Pulsatile Drug Delivery Systems: An Overview." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 3 (2009): 605–14. http://dx.doi.org/10.37285/ijpsn.2009.2.3.3.

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Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. These systems are designed according to the circadian rhythm of the body. The principle rationale for the use of pulsatile release of the drugs is where a constant drug release is not desired. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. Various systems like capsular systems, osmotic systems, single- an

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10

N., Shiva Krishna* Dr. B. Jayanthi A. Madhukar. "A REVIEW OF PULSATILE DRUG DELIVERY SYSTEM." Indo American Journal of Pharmaceutical Sciences 05, no. 06 (2018): 5488–94. https://doi.org/10.5281/zenodo.1296981.

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<em>Pulsatile drug delivery systems are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site.the product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. diseases where in chronopharmaceutics are promising include asthma,peptic ulcers, cardiovascular diseases, arthritis, neurological disorders and hypercholesterolemia etc. various capsular, osmotic, single and multiple unit systems that are modulated by soluble (or) er

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