Relevant bibliographies by topics / CIN 2

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Academic literature on the topic 'CIN 2'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "CIN 2"

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Crum, Christopher P. "Laboratory Management of CIN 2." American Journal of Clinical Pathology 130, no. 2 (August 2008): 162–64. http://dx.doi.org/10.1309/gcvb5c4kfv7tfc7f.

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Corona Gutierrez, Carlos Manuel, Alberto Tinoco, Tania Navarro, Mario López Contreras, Roberto Risco Cortes, Patricia Calzado, Lise Reyes, et al. "Therapeutic Vaccination with MVA E2 Can Eliminate Precancerous Lesions (CIN 1, CIN 2, and CIN 3) Associated with Infection by Oncogenic Human Papillomavirus." Human Gene Therapy 15, no. 5 (May 2004): 421–31. http://dx.doi.org/10.1089/10430340460745757.

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Mastutik, Gondo, Rahmi Alia, Alphania Rahniayu, Anny Setijo Rahaju, and Renny I’tishom. "Human pappilomavirus genotype in cervical tissue of patients with Cervical Intraepithelial Neoplasia (CIN) 1, CIN 2, and CIN 3." Majalah Obstetri & Ginekologi 24, no. 3 (June 21, 2017): 74. http://dx.doi.org/10.20473/mog.v24i3.4568.

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Objectives: to determine the genotype of HPV in patients with precancerous lesions of cervical tissue.Materials and Methods: An observational study with cross sectional study of patients paraffin block CIN1, CIN2, CIN3 was conducted in Dr Soetomo Hospital. HPV DNA was extracted from paraffin blocks, then performed PCR and genotyping of HPV. The sample consisted of 28 patients with cervical tissue paraffin blocks CIN1, CIN2 and CIN3. Patients aged between 26-74 years (standard deviation 10,12).Results: HPV genotypes that infect patients with CIN1 were HPV16 and 18, CIN2 were HPV16 and 52 and CIN3 were HPV16, 67, and combined infection HPV16/67 and HPV52/67. HPV genotypes in a single infection were 26/28 (HPV16, HPV18, HPV52 and HPV67), and multiple infections were 2/28 (HPV16/67 and HPV52/67).Conclusion: The most dominant HPV genotypes infect patients with precancerous lesions of the cervix were HPV16, HPV67, HPV52, and HPV18.
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Mastutik, Gondo, Rahmi Alia, Alphania Rahniayu, Anny Setijo Rahaju, Renny I’tishom, and Suhartono Taat Putra. "Human pappilomavirus genotype in cervical tissue of patients with Cervical Intraepithelial Neoplasia (CIN) 1, CIN 2, and CIN 3." Majalah Obstetri & Ginekologi 24, no. 3 (March 31, 2018): 74. http://dx.doi.org/10.20473/mog.v24i32016.74-78.

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Objectives: to determine the genotype of HPV in patients with precancerous lesions of cervical tissue.Materials and Methods: An observational study with cross sectional study of patients paraffin block CIN1, CIN2, CIN3 was conducted in Dr Soetomo Hospital. HPV DNA was extracted from paraffin blocks, then performed PCR and genotyping of HPV. The sample consisted of 28 patients with cervical tissue paraffin blocks CIN1, CIN2 and CIN3. Patients aged between 26-74 years (standard deviation 10,12).Results: HPV genotypes that infect patients with CIN1 were HPV16 and 18, CIN2 were HPV16 and 52 and CIN3 were HPV16, 67, and combined infection HPV16/67 and HPV52/67. HPV genotypes in a single infection were 26/28 (HPV16, HPV18, HPV52 and HPV67), and multiple infections were 2/28 (HPV16/67 and HPV52/67).Conclusion: The most dominant HPV genotypes infect patients with precancerous lesions of the cervix were HPV16, HPV67, HPV52, and HPV18.
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Katki, Hormuzd A., Mark Schiffman, Philip E. Castle, Barbara Fetterman, Nancy E. Poitras, Thomas Lorey, Li C. Cheung, Tina Raine-Bennett, Julia C. Gage, and Walter K. Kinney. "Five-Year Risk of Recurrence After Treatment of CIN 2, CIN 3, or AIS." Journal of Lower Genital Tract Disease 17 (April 2013): S78—S84. http://dx.doi.org/10.1097/lgt.0b013e31828543c5.

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Demarco, Maria, Thomas S. Lorey, Barbara Fetterman, Li C. Cheung, Richard S. Guido, Nicolas Wentzensen, Walter K. Kinney, et al. "Risks of CIN 2+, CIN 3+, and Cancer by Cytology and Human Papillomavirus Status." Journal of Lower Genital Tract Disease 21, no. 4 (October 2017): 261–67. http://dx.doi.org/10.1097/lgt.0000000000000343.

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Towler, Bernadette P., Les M. Irwig, and Julia M. Shelley. "The adequacy of management of women with CIN 2 and CIN 3 Pap smear abnormalities." Medical Journal of Australia 159, no. 8 (October 1993): 523–28. http://dx.doi.org/10.5694/j.1326-5377.1993.tb138005.x.

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Windrum, Graham. "The adequacy of management of women with CIN 2 and CIN 3 Pap smear abnormalities." Medical Journal of Australia 160, no. 3 (February 1994): 165–66. http://dx.doi.org/10.5694/j.1326-5377.1994.tb126581.x.

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Carcopino, X., C. Muszynski, J. L. Mergui, J. Gondry, and L. Boubli. "La CIN 2 merite-t-elle la même prise en charge que la CIN 3 ?" Gynécologie Obstétrique & Fertilité 39, no. 2 (February 2011): 94–99. http://dx.doi.org/10.1016/j.gyobfe.2010.11.001.

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Sykes, Peter, Carrie Innes, Dianne Harker, Martin Whitehead, Rachael van der Griend, Beverley Lawton, Merilyn Hibma, et al. "Observational Management of CIN 2 in Young Women." Journal of Lower Genital Tract Disease 20, no. 4 (October 2016): 343–47. http://dx.doi.org/10.1097/lgt.0000000000000244.

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Dissertations / Theses on the topic "CIN 2"

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Genovès, Gonzàlez Jordi. "Evolució de les lesions CIN-2 segons la P16 i el Ki-67." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/666934.

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Les lesions cervicals intraepitelials estan causades per la infecció persistent del virus del papil·loma humà (VPH) en les variants d’alt risc. Si no es resolen, poden créixer i provocar l’aparició d’un càncer de cèrvix uterí. Les lesions CIN-2 són un grau intermig d’aquestes lesions, amb una capacitat de regressió aproximada del 40% (tot i que en noies joves s’estima un 60%) i amb una capacitat de progressió a CIN-3 (pre-càncer) del 22%. El CIN-3 només té una regressió del 32%. Actualment aquestes lesions CIN-2 i CIN-3 es tracten de la mateixa manera amb cirurgia tot i tenir un comportament diferent, de manera sobretractem pacients que no ho necessitarien perquè podrien eliminar la lesió. La intervenció quirúrgica, anomenada conització, es basa en exèresi del fragment més extern del coll uterí, i en cas de realitzar-se més d’una vegada, està associat a problemes obstètrics posteriors com part preterme. La p16 és una proteïna que regula el cicle cel·lular i es troba augmentada en una infecció per un VPH d’alt risc. El Ki-67 és una proteïna del nucli cel·lular que es troba en totes les cèl·lules en replicació. El nostre treball té l’objectiu de descriure la taxa de regressió de les lesions CIN-2 passats 12 mesos de control i veure la relació amb l’estat de la p16 i Ki-67 al diagnòstic. La nostra hipòtesi és que un augment de l’expressió de la p16 i del Ki-67 indiquen una lesió en replicació activa, que necessita de tractament quirúrgic. Vàrem dissenyar un estudi prospectiu observacional per al seguiment de pacients amb biòpsia de CIN-2. Es van reclutar 96 pacients que complien criteris d’inclusió i van entrar en l’estudi estadístic final. Es varen seguir les pacients amb citologies i colposcòpia cada 4 mesos, per un màxim de 12 mesos, moment en el qual es realitzava una biòpsia de control per a comprovar l’evolució de la lesió. Les pacients podien seguir si ho desitjaven amb el seguiment 12 mesos més, fins a completar 24 mesos dins l’estudi que compartia aquesta cohort sobre el paper de les cèl·lules Natural Killer en l’evolució del CIN-2. La taxa de regressió completa a curació als 12 mesos va ser del 64% (regressió total 26% i parcial 38%), i el 8% van progressar a un CIN-3. Les característiques epidemiològiques de les pacients (edat, hàbit tabàquic, contracepció, edat d’inici de les relacions sexuals, nombre total de parelles i paritat) no tenien diferències significatives. El 100% de les pacients amb p16 negativa van regressar a CIN<2. Totes les pacients que van progressar van ser p16 positives. El 57% de les pacients amb p16 positiva van regressar també. El 100% de les pacients amb Ki-67 negativa va regressar a CIN<2. Totes les pacients que van progressar eren Ki-67 positives, i el 59,3% de les pacients p16 positives també van regressar. Una citologia diagnòstica de H-SIL, la infecció pel VPH i en particular del VPH-16, van estar associades a la no regressió de les pacients. La detecció del VPH negativa estaba associada a la regressió. Els canvis majors de la colposcòpia, les lesions de més del 50% del cèrvix i els patrons irregulars estaven associats a la no regressió. Les nostres dades donen seguretat a un maneig més conservador de les lesions CIN-2 que siguin p16 i Ki-67 negatives, de manera que no sobretractem pacients que es beneficiarien de control amb observació i evitaríem possibles complicacions obstètriques posteriors.
Intraepithelial cervical lesions are caused by persistent infection of a high risk human papilloma (HPV). If they are not resolved, they can grow and cause cervical cancer. CIN-2 lesions are an intermediate degree, with a regression rate of 40% (although in young women is 60%) and with a progression rate of CIN-3 (pre-cancer) of 22%. CIN-3 only has a 32% chance of regression. CIN-2 and CIN-3 are treated with surgery despite having a different behavior, so we overtreat patients who would not need it because they could solve the lesion. The surgical intervention is called conization, and is based on removing the outermost fragment of the cervix. It is associated to later obstetric problems such as preterm delivery when performed more than once. Biological markers are proteins that can be identified in these lesions. P16 is a protein involved in cell cycle regulation and its overexpression appears in high-risk HPV infections. Ki-67 is a nuclear protein found in all replicating cells. Our work aims to describe the outcome of CIN-2 lesions followed without treatment during 12 months to evaluate regression rates according to p16 and Ki-67 staining status. Patients with first time histologic diagnosis of CIN-2, older than 18 years old, with satisfactory colposcopy, agreed to follow-up every 4 months for at least 2 years, were prospectively recruited. Previous abnormal cytology and high-risk HPV were reported at baseline. p16 and Ki-67 expression were analyzed on CIN-2 biopsies. Regression was defined as CIN1 biopsy or two consecutive negative cytology, persistence as CIN2 biopsy and progression as histologic diagnosis of CIN3. All patients with CIN3 biopsy were treated with cone excision. The rate of spontaneous regression at 12 months was 65.7%, while 7.8% progressed and 26.5% had a persistent disease. Regression was observed in all p16 negative cases and 56.8% of the p16 positive. All Ki-67 negative cases and 59.3% of the Ki-67 positive cases regressed. HSIL previous cytology, HPV-16 and HPV-18 infection were statistically associated to non-regression compared to regression while HPV-negative was associated to regression. Big lesions (more than 50% of the cervix surface), irregular pattern and major colposcòpic changes were related to non regression. Conclusion The high regression rate of CIN-2 supports clinical observation in selected patients. Our data support that CIN-2 patients with negative p16 and Ki-67 are safe to follow conservative management. It also suggests that HPV-negative and non-HSIL patients should follow less strict follow up. Biomarkers predicting CIN2 regression seem to have a great clinical value and could reduce unnecessary cone excisions and associated complications.
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Forteza, Valadés Ana. "Validación de la sobreexpresión de la proteína p16 mediante inmunohistoquímica en el diagnóstico histológico de neoplasia intraepitelial de cérvix grado 2 y en la predicción de su capacidad evolutiva." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/663821.

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Introducción A principios de los años 70 quedó claramente establecido que el Virus del Papiloma Humano (VPH) es el agente causal del cáncer de cérvix. Además, su historia natural, de una decena de años, desde la infección hasta la aparición del cáncer, está muy bien estudiada. Estas características, hacen que el cáncer de cérvix sea una enfermedad idónea para establecer programas de prevención, tanto primaria como secundaria. Las lesiones preneoplásicas de cérvix, suponen un número muy elevado de consultas y reconsultas, generando ansiedad a las pacientes, generalmente jóvenes, que en ocasiones, deben ser sometidas a intervenciones quirúrgicas. Esto supone un elevado coste para la sanidad pública, por tanto debemos tratar de ser los más eficientes, seleccionando bien a las pacientes a seguir y tratar. Objetivos del estudio Valorar la idoneidad del uso de la clasificación en tres grados 1 – 2 y 3 de las neoplasias intrepiteliales de cérvix (CIN) estudiando la concordancia entre patólogos a la hora de establecer diagnósticos. Estudiar como modifica la concordancia entre ellos la tinción de Inmunohistoquímica p16 y valorar la idoneidad del uso de la clasificación binaria – lesiones de alto o bajo grado – para el diagnóstico de estas mismas lesiones. Estudiaremos también si p16 puede predecir qué lesiones evolucionaran peor. Material y método Hemos recogido de nuestro archivo 132 biopsias de cérvix diagnosticadas entre 1999 y 2007 de CIN 2, y las hemos mezclado con una muestra aleatoria de 154 biopsias de cérvix más, con diagnóstico de Negativo, CIN 1, CIN 2, CIN 3 o carcinoma. Las hemos hecho reevaluar por tres patólogos diferentes, estableciendo índices de concordancia. Posteriormente hemos realizado p16 a una representación de las biopsias para volver a establecer datos de concordancia. Después, pasamos una selección aleatoria de 50 biopsias teñidas sólo con HE para establecer el diagnóstico en base a la clasificación binaria. También hemos estudiado la relación entre el resultado de p16 de las biopsias de CIN 2 y el resultado de la conización posterior. Resultados y Discusión El índice de concordancia (índice Kappa) entre los diferentes patólogos a la hora de establecer un diagnóstico sobre la biopsia pequeña de cérvix con HE se sitúa alrededor de 0,40, siendo más bajo para las lesiones CIN 1 y CIN 2 que para los diagnósticos CIN3. Con el uso indiscriminado de p16 no sólo no mejora, si no que empeora, en cambio sí observamos una notable mejoría del índice Kappa utilizando la clasificación binaria (llega a alcanzar un valor de 0,75) que mejora utilizando p16 conjuntamente (hasta 0,82). En la mayor parte de los casos las biopsias CIN 2 que fueron positivas para p16 presentan una pieza de conización con una lesión de alto grado (CIN2+) pero no en el 100% de los casos, y también encontramos casos con p16 negativa que van seguidas de una lesión de alto grado. Conclusiones La clasificación binaria de las lesiones preneoplásicas de cérvix, mejora la concordancia interobservador a la hora de establecer diagnósticos. P16 ayuda, si se utiliza después de una formación, y se reserva para aquellos casos dudosos. No se pueden establecer diagnósticos basados sólo en el resultado de p16, es un complemento a la hematoxilina.
Introduction In the early 70's it was clearly established that the Human Papillomavirus (HPV) is the causative agent of cervical cancer. In addition, its natural history, of about ten years, from infection to the appearance of cancer, is very well studied. These characteristics make cervical cancer an ideal disease to establish prevention programs, both primary and secondary. The preneoplastic lesions of the cervix, suppose a very high number of consultations and reconsultations, generating anxiety to the patients, generally young, that sometimes, must be submitted to surgical interventions. This supposes a high cost for the public health, therefore we must try to be the most efficient, selecting the patients well to follow and treat.   Objectives of the study To assess the suitability of the use of the classification in three grades 1 - 2 and 3 of the intraepithelial neoplasms of the cervix (CIN), studying the agreement between pathologists when establishing diagnoses. To study how the agreement between them corrects the p16 Immunohistochemical staining and to evaluate the suitability of the use of the binary classification - high or low grade lesions - for the diagnosis of these same lesions. We will also study if p16 can predict which lesions will evolve worse.   Material and method We have collected from our archive 132 cervical biopsies diagnosed between 1999 and 2007 of CIN 2, and we have mixed them with a random sample of 154 more cervical biopsies, with a diagnosis of Negative, CIN 1, CIN 2, CIN 3 or carcinoma. We have reevaluated them by three different pathologists, establishing concordance rates. Subsequently we performed p16 to a representation of the biopsies to re-establish concordance data. Then, we passed a random selection of 50 biopsies stained with HE only to establish the diagnosis based on the binary classification. We have also studied the relationship between the p16 result of the CIN 2 biopsies and the result of the subsequent conization.   Results and Discussion The concordance index (Kappa index) between the different pathologists when establishing a diagnosis of small biopsies of the cervix with HE is around 0.40, being lower for the CIN 1 and CIN 2 lesions than for the diagnoses CIN3. With the indiscriminate use of p16 not only does it not improve, but it does get worse, however we do observe a notable improvement in the Kappa index using the binary classification (it reaches a value of 0.75) that improves using p16 together (up to 0, 82). In most cases the CIN 2 biopsies that were positive for p16 present a conization piece with a high-grade lesion (CIN2 +) but not in 100% of the cases, and we also found cases with negative p16 that are followed of a high-grade injury.   Conclusions The binary classification of preneoplastic lesions of the cervix improves the interobserver concordance when establishing diagnoses. P16 helps, if used after a training, and is reserved for those doubtful cases. You can not establish diagnoses based only on the result of p16, it is a complement to hematoxylin.
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Carrasco, García Miguel Ángel. "Neoplasia Intraepitelial Cervical grado II y III: Estudio morfométrico de sus diferencias y relación con el Virus del Papiloma Humano." Doctoral thesis, Universitat Internacional de Catalunya, 2010. http://hdl.handle.net/10803/9355.

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El propòsit del nostre treball és valorar morfomètricament les diferències existents entre la Neoplàsia Intraepitelial Cervical (CIN) grau 2 i 3, així com el tipus de Virus del Papil·loma Humà (VPH) present, estudiat mitjançant Hibridació in situ.
Hem estudiat 66 peces quirúrgiques d'exèresi del coll uterí de pacients amb diagnòstic histològic de CIN 2 i 82 de CIN 3. Hem demostrat amb el nostre estudi que la superfície afectada en el coll cervical per CIN 3 és significativament més gran que la de CIN 2, a la vegada que són lesions longitudinalment majors, amb major afectació glandular, major profunditat en l'afectació glandular i major índex mitòtic. També hem pogut demostrar que VPH 16/18 predomina en CIN 3. No hem trobat diferències significatives en quant a la presència de papil·les vasculars en ambdues lesions i tampoc hem trobat relació entre tipus de VPH i àrea afectada per CIN, així com entre tipus de VPH i edat de la pacient.
El propósito de nuestro trabajo es valorar morfométricamente las diferencias existentes entre la Neoplasia Intraepitelial Cervical (CIN) grado 2 y 3, así como el tipo de Virus del Papiloma Humano (VPH) presente, estudiado mediante Hibridación in Situ.
Hemos estudiado 66 piezas quirúrgicas de exéresis del cuello cervical de pacientes con diagnóstico histológico de CIN 2 y 82 de CIN 3. Hemos demostrado con nuestro estudio que la superficie afectada en el cuello cervical por CIN 3 es significativamente mayor que la de CIN 2, a la vez que son lesiones longitudinalmente mayores, con mayor afectación glandular, mayor profundidad en la afectación glandular y mayor índice mitótico. También hemos podido demostrar que VPH 16/18 predomina en CIN 3. No hemos encontrado diferencias significativas en cuanto a la presencia de papilas vasculares en las dos lesiones y tampoco hemos encontrado relación entre tipo de VPH y área afectada por CIN, así como entre tipo de VPH y edad de la paciente.
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Westin, Maria Cristina do Amaral 1949. "Expressão das proteínas MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 e VEGF-A na NIC 3 e no carcinoma invasor do colo do útero = Expression of the proteins MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 and VEGF-A in the CIN 3 and cervical cancer." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313599.

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Orientadores: Luiz Carlos Zeferino, Silvia Helena Rabelo dos Santos
Texto em português e inglês
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-23T06:30:30Z (GMT). No. of bitstreams: 1 Westin_MariaCristinadoAmaral_D.pdf: 3122088 bytes, checksum: 3d2afed3690cd3566bbb3fe26bb492a3 (MD5) Previous issue date: 2013
Resumo: Introdução: O carcinoma escamoso do colo uterino é precedido pela neoplasia intraepitelial cervical grau 3 (NIC 3). A invasão tumoral envolve a degradação da matriz extracelular e membrana basal do epitélio por enzimas proteolíticas denominadas metaloproteinases (MMPs). Os inibidores teciduais das metaloproteinases (TIMPs) também interferem no processo de invasão. Angiogênese é condição indispensável para a progressão tumoral. Objetivo: Analisar a expressão de MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 e VEGF-A na NIC 3 e carcinoma do colo uterino. Sujeito e Métodos: Estudo do tipo comparativo observacional constituído de três grupos:- Grupo 1: 55 casos com diagnóstico de NIC 3, Grupo 2: 30 casos com NIC 3 e carcinoma associados e Grupo 3: 46 casos com carcinoma. A expressão protéica foi pesquisada separadamente nas células tumorais e estromais por reação imunoistoquímica. Para estabelecer a porcentagem de células imunopositivas utilizou-se software morfométrico. Análise Estatística: Aplicou-se o Teste T-pareado ou de Mann-Whitney ou Wilcoxon Signed Rank. Resultados: Em todos os grupos, a expressão tumoral de MMP-14 foi maior que a estromal. Inversamente, a expressão de TIMP-2 foi maior nas células estromais que nas tumorais, em cada grupo diagnóstico. A expressão de MMP-9 foi maior nas células estromais que nas tumorais, com exceção do componente invasor do Grupo 2. A expressão estromal de TIMP-1 foi maior que a tumoral no carcinoma e, ao contrário, sua expressão foi maior nas células tumorais da NIC 3. A expressão de VEGF-A foi maior apenas nas células tumorais da NIC 3. Comparando a expressão dos marcadores entre os grupos, foram encontradas as maiores diferenças entre grupos extremos, ou seja, entre NIC 3 e carcinoma. A expressão de MMP-2 nas células estromais foi maior no componente NIC 3 do Grupo 2 que no NIC 3 do Grupo 1. A expressão de VEGF-A nas células estromais do carcinoma foi maior que nas células estromais da NIC 3. Conclusões: Os resultados deste estudo sugerem que a expressão de TIMP-1 aumenta nas células do estroma e diminui nas células tumorais quando a NIC 3 progride para carcinoma invasor. MMP-9 e TIMP-2 tiveram expressão similar na NIC 3 e no carcinoma, o que limita inferências sobre seu papel na progressão neoplásica. O padrão imunoistoquímico da expressão das MMPs, TIMPs e VEGF-A na NIC 3 e no carcinoma invasivo, quando estas lesões estavam associadas, foi semelhante. A expressão do VEGF-A foi maior nas células tumorais do que nas estromais da NIC 3, porém quando esta lesão progride para carcinoma invasivo sua expressão aumenta nas células do estroma e não se altera nas tumorais. A expressão de MMP-14, MMP-2, TIMP-1 e VEGF-A aumentou com a gravidade da neoplasia
Abstract: Introduction: Squamous cell carcinoma of the cervix is preceded by cervical intraepithelial neoplasia grade 3 (CIN 3). Tumor invasion involves degradation of extracellular matrix and epithelium basement membrane by proteolytic enzymes called metalloproteinases (MMPs). Tissue inhibitors of metalloproteinases (TIMPs) are also involved in the invasion process. Angiogenesis is a prerequisite for tumor progression. Objective: To analyze the expression of MMP-2, MMP-9 and MMP-14, TIMP-1, TIMP-2 and VEGF-A in CIN 3 and invasive carcinoma. Subject and Methods: This comparative observational study was consists of three groups: Group 1: 55 cases diagnosed with CIN 3, Group 2: 30 cases with CIN 3 associated with invasive carcinoma and Group 3: 46 cases with invasive carcinoma. Protein expression was investigated separately in tumor and stromal cells by immunohistochemistry and evaluated by the percentage of cells positive for immunostaining using morphometric software. Statistical Analysis: Was performed applying paired t-test or Mann-Whitney or Wilcoxon Signed Rank. Results: In each diagnostic group, expression markers were significantly higher: MMP-14 in tumor cells, and TIMP-2 in stromal cells; also MMP-9 expression was significantly higher in stromal cells, except in invasive component of group 2, and TIMP-1 had significantly higher expression in stromal cells of invasive carcinoma and in tumor cells of CIN 3. VEGF-A expression was significantly higher only in tumor cells CIN 3. Comparing the expression of markers between groups, two by two, we find the greatest differences between the extreme groups, i.e. between invasive carcinoma and CIN 3. The expression of MMP-2 was significantly greater in the stromal component CIN 3 in group 2 than in CIN 3 only. The expression of VEGF-A was significantly higher in the group stromal cell carcinoma when compared to stromal cells CIN 3. Conclusions: The results of this study suggest that the expression of TIMP-1 increases in the stromal cells and decreases in tumor cells when CIN 3 progresses to invasive carcinoma. MMP-9 and TIMP-2 had similar expression in CIN 3 and invasive carcinoma, which limits inferences about its role in neoplastic progression. The immunohistochemical pattern of expression of MMPs, TIMPs and VEGF-A in CIN 3 and invasive carcinoma, as these lesions were associated, was similar. The expression of VEGF-A was higher in tumor cells than in stromal cells in CIN 3, but when the lesion progresses to invasive carcinoma its expression increases in the stromal cells and the tumor cells does not change. The expression of MMP-14, MMP-2, TIMP-1 and VEGF-A was increased with the severity of the neoplasia
Doutorado
Oncologia Ginecológica e Mamária
Doutora em Ciências da Saúde
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Pita, César. "CineScrúpulos (Año 1. Número 2. Abril de 2013)." Universidad Peruana de Ciencias Aplicadas (UPC), 2013. http://hdl.handle.net/10757/625039.

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CineScrúpulos es una revista digital que recopila los trabajos desarrollados por los alumnos en la clase de Historia del Cine de la Facultad de Comunicaciones de la UPC. El curso no pretende brindar una visión historicista del cine repleta de fechas, nombres de directores, títulos de películas y lugares exóticos, sino que intenta evidenciar la linealidad casi genética que es intrínseca al quehacer fílmico, una tradición que no solo se repite sino que se reinterpreta en distintos escenarios y en distintos momentos. Porque se entiende que el cine es, ante todo, la herencia permanente de lo que se ha hecho antes. Los textos de la revista CineScrúpulos han sido elaborados por los alumnos, profesores y colaboradores de la Facultad de Comunicaciones de la Universidad Peruana de Ciencias Aplicadas. Las imágenes utilizadas han sido obtenidas de distintas páginas web y el uso de las mismas se inscribe en lo estrictamente académico y divulgativo.
La presente edición de Cinescrúpulos se centra en la obra de Stanley Kubrick, excéntrico y extraño, alejado de los reflectores en los últimos años de su vida pero entregado en cuerpo y alma al entorno familiar. El director legó una filmografía del crecimiento, del descubrimiento, del enaltecimiento de la experimentación, del regocijo que origina evitar los formulismos del género, de encontrar la independencia tras haber flirteado con el monstruo corporativo, de no hacerle ascos al terror o al erotismo, de jugar cada una de sus piezas con la maestría del ajedrecista nato que era. También nos damos un tiempo para descubrir los vínculos que existen entre el cine de Charles Chaplin y la construcción de personajes y narrativas que han encumbrado a Pixar como una de las opciones más inteligentes en el terreno de los dibujos animados de los últimos años. Y como broche de oro, una pregunta válida: Francisco Lombardi, nuestro cineasta con la mayor cantidad de títulos estrenados en salas, ¿estará construyendo un cine de género en el Perú o apunta más bien hacia otro lado?.
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Yates, Thomas E. "Can we out-walk the type 2 diabetes mellitus epidemic?" Thesis, Loughborough University, 2008. https://dspace.lboro.ac.uk/2134/8077.

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Type 2 diabetes mellitus is a chronic and debilitating disease whose prevalence continues to rise inexorably. Type 2 diabetes is usually preceded by a condition called prediabetes, which is characterised by impaired glucose regulation. Those with prediabetes have a significantly increased risk of developing type 2 diabetes compared to those with normal glucose control and therefore represent a key population in the prevention of type 2 diabetes. Physical inactivity is thought to be one of the key factors driving the increasing prevalence of prediabetes and type 2 diabetes and consequently forms a pivotal focus of initiatives aimed at their prevention. The principal aims of this thesis were to: 1) conduct a systematic review investigating the effectiveness of lifestyle and physical activity interventions at promoting physical activity in individuals with prediabetes and the effect of physical activity change on the risk of developing diabetes; 2) investigate the effect of walking activity on markers of chronic low grade inflammation; and 3) design and evaluate with objectively measured endpoints a physical activity intervention for adults at risk of developing type 2 diabetes that is suitable for implementation in a health care or community setting if found to be effective. The main findings are listed in the order of the stated aims. 1) Due to the dearth of controlled exercise training studies in those with prediabetes and the absence of evidence that previous diabetes prevention programmes have been successful at initiating clinically significant increases in physical activity, the evidence for the efficacy of physical activity behaviour change at prevention or delaying the progression to type 2 diabetes in those with prediabetes is equivocal. 2) Walking at levels that are consistent with the current physical activity recommendations is associated with reduced chronic low-grade inflammation, independent of other forms of physical activity. 3) The PREPARE programme, developed after a review of health behaviour theory and the current health care climate, is a theorydriven, group-based structured education programme designed to promote increased walking activity in individuals with prediabetes in a health care setting. A randomized controlled trial was conducted to test two versions of the PREPARE programme, a standard version and a pedometer version, against control conditions (advice leaflet). The standard version encouraged participants to set time-based goals based on generic exercise recommendations, whereas the pedometer version enabled participants to set personalized steps-per-day goals and to objectively self-monitor their daily physical activity levels using a pedometer. One hundred and three individuals were recruited to the study and follow-up was conducted at 3,6 and 12 months. At 12 months both intervention conditions were successful at achieving significant increases in objectively measured ambulatory activity; compared to the control group, those who received the pedometer version of the PREPARE programme increased their ambulatory activity by 1952 steps per day (95% CI 953 to 2951) and those who received the standard version by 1480 steps per day (95% CI 436 to 2522). However, significant improvements in glucose tolerance were only seen in the pedometer group, where 2-h glucose levels decreased by -0.94 mmol/l (95% Cl -1.79 to - 0.10) compared to control conditions, despite no significant change in body weight or waist circumference. This thesis has identified important limitations in the current evidence linking physical activity to the prevention of type 2 diabetes in those with prediabetes and has addressed several of these limitations by developing a theory-driven structured education programme which was shown to be successful at promoting physical activity and improving glucose tolerance in those with prediabetes to levels that are equal to or greater than previous multifactor diabetes prevention programmes. This is likely to have important implications for future diabetes prevention trials and clinical practice in the United Kingdom.
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Davaine, Tristan. "Catch me if you can - En studie om operativ risk i svenska försäkringsföretag." Thesis, Linnéuniversitetet, Institutionen för ekonomistyrning och logistik (ELO), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-76609.

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Bakgrund: Operativ risk är ett begrepp som har tilltagit i betydelse genom uppdagandet av skandaler och konkurser inom den finansiella sektorn. Varje svenskt försäkringsföretag är skyldigt att hantera operativa risker, men eftersom det är omöjligt att normalisera dess innebörd, åligger det företagen själva att avgöra dess omfång. Många ansträngningar har gjorts vad gäller att rama in och beskriva denna kategori för ”allmän rädsla”, en uppgift som fortsatt lider av brist på konsensus. Syfte: Syftet med denna studie är att fördjupa kunskapen om den operativa risken, sett ur de svenska försäkringsföretagens perspektiv, och sättet till vilket ett givet förhållningssätt inverkar på riskhanteringsprocessen. Metod: Studien har genomförts i två steg. Den första delen har utgjorts av en dokumentstudie, vilken sedermera har fördjupats genom två fallstudier. Slutsats: Studien visar att det finns en mängd tolkningar av operativ risk, vilka sträcker sig från väldigt enklar till väldigt komplexa. Studien visar också att vissa företag inte hanterar sina risker med utgångspunkt i konceptet ”operativ risk”, utan antar en mer pragmatisk inställning till verksamheternas risker. Detta innebär att det finns ett gap förhållande till god praxis kring hanteringen av operativ risk, vilket kompenseras för genom en ökad verksamhetsförståelse och tillämpningen av metoder som inte nödvändigtvis associeras med riskhantering.
Background: Operational risk is a notion that has gained a lot of notoriety due to a number of scandals and bankruptcies within the financial sector. Every Swedish insurance company is obliged to manage its operational risks, and due to the impossibility of normalizing its specific content, it is up to the companies themselves to judge its extent. Many efforts have been made to conceptualize and explain this “fear category”, an effort that in many respects still lacks in consensus. Purpose: The purpose of this study is to increase the knowledge of what constitutes operational risk, from the perspective of Swedish insurance companies, and the way in which a particular view affects the risk management process.  Methods: This study has been conducted in two parts. The first part constitutes a cross-sectional study, which has further been expanded on by conducting a multiple case study, encompassing two insurance companies. Conclusion: This study shows that there are many interpretations of operational risk, ranging from very simple to very complex. This study also shows that some companies do not manage risks based on the concepts of “operational risk”, but from a pragmatic approach towards the business, meaning that some of the foundational good practices are not applied. However, this is mitigated by an increased understanding of the business, as well as the application of methods not necessarily associated with risk management.
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Paiva, Melissa. "I can explain! understanding perceptions of eyewitnesses as a function of type of explanation and inconsistent confidence statements /." View thesis online, 2009. http://docs.rwu.edu/psych_thesis/2/.

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Cesur, Halil. "Development Of Cubic Boron Nitride (cbn) Coating Process For Cutting Tools." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/2/12610640/index.pdf.

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In today&
#8217
s market conditions, higher tool life and durable cutting tools which can stand high cutting speeds are required in chip removal process. In order to improve the performance of cutting tools, coatings are employed extensively. Cubic boron nitride (cBN) is a new kind of coating material for cutting tools due to its outstanding properties and testing of cBN as a hard coating for machining have been increasing in recent years. However, there are some challenges such as compressive residual stress, poor adhesion and limiting coating thickness during the deposition of cBN on substrates. In this study, cubic boron nitride (cBN) coatings are formed on cutting tools from hexagonal boron nitride (hBN) target plates. For this purpose, a physical vapor deposition (PVD) system is utilized. PVD system works on magnetron sputtering technique in which material transfer takes place from target plate to substrate surface. Firstly, cBN coatings are deposited on steel and silicon wafer substrates for measurements and analyses. Compositional, structural and mechanical measurements and analysis are performed for the characterization of coatings. Next, several types of cutting tools are coated by cBN and the effects of cBN coatings on cutting performance are investigated. Finally, it can be said that cubic boron nitride coatings are successfully formed on substrates and the improvement of wear resistance and machining performance of cBN coated cutting tools are observed.
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Lahiouel, Rachid. "Evolution du réseau Kondo en fonction de l'hybridation : les systèmes CeIn(Ag,Cu)2 et Ce(Ge,Si)2." Grenoble 1, 1987. http://www.theses.fr/1987GRE10054.

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Observation du passage d'un regime kondo mixte a un regime kondo pur ou a un regime de valence intermediaire sous l'effet de la pression chimique. Etude du diagramme de phases magnetiques. Determination du coefficient de couplage entre electrons 4 f et la bande de conduction jn(e::(f)). Coefficient de la chaleur specifique, temperature de kondo et coefficient de grueneisen electronique de ceincu::(2)
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Books on the topic "CIN 2"

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L'immaturità psico-affettiva e matrimonio canonico (can. 1095, 2-3 CIC). Città del Vaticano: Libreria editrice vaticana, 2009.

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Amy, Gilbert. Symphonies pour cinq cuivres. Paris: Amphion, 1993.

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Latulippe, Gilles. Vingt-cinq sketches. 2. Montréal: Elaeis, 1999.

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Haim, Victor. Cinq comedies grincantes. Paris: Art et comedie, 2001.

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liang, Ma. Xin gai nian ying yu 2 ci hui chang xiao ji yi. Bei jing: Zhong guo shui li shui dian chu ban she, 2011.

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Xin gai nian ying yu 2 dan ci MP3 xun huan ting. Bei jing: Zhong guo shui li shui dian chu ban she, 2009.

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Haim, Victor. Cinq comedies en duo. Paris: Art et comedie, 2001.

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Arshad, Hang Tuah. Vokabulari Melayu-Cina: Bahagian 1 & 2. Petaling Jaya, Selangor, Malaysia]: Meoral Pub. House, 2009.

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Bankers, Chartered Institute of. CIB practice & revision kit: Stage 2. London: BPP, 1990.

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Grave Sins (Cin Craven #2). St. Martin's Paperback, 2009.

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Book chapters on the topic "CIN 2"

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McNeill, Patrick. "Accidents can Happen." In Society Today 2, 126–28. London: Macmillan Education UK, 1991. http://dx.doi.org/10.1007/978-1-349-12065-9_42.

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Arya, Ali. "Introduction." In Anyone Can Code, 3–19. First edition. | Boca Raton : CRC Press, 2020.: Chapman and Hall/CRC, 2020. http://dx.doi.org/10.1201/9780429244421-2.

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Domènech, Conxita, Andrés Lema-Hincapié, and Javier Muñoz-Basols. "La Huerta de España." In Saberes con sabor, 18–37. New York : Routledge, 2020.: Routledge, 2020. http://dx.doi.org/10.4324/9780429433597-2.

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Chambers, Robert. "CHAPTER 2: Biases and blind spots." In Can We Know Better?, 27–56. The Schumacher Centre, Bourton on Dunsmore, Rugby, Warwickshire, CV23 9QZ, UK: Practical Action Publishing Ltd, 2017. http://dx.doi.org/10.3362/9781780449449.002.

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Crosby, Gilmore. "Leadership." In Leadership Can Be Learned, 3–4. Boca Raton, FL : CRC Press, 2018.: Productivity Press, 2017. http://dx.doi.org/10.4324/9781315099293-2.

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Leo, Bottaryt. "No One Does It Alone, So Why Should You?" In What Anyone Can Do, 1–12. New York, NY : Taylor & Francis, [2018]: Routledge, 2018. http://dx.doi.org/10.4324/9781315151298-2.

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Connelly, Philip W., Graham F. Maguire, and J. Alick Little. "Familial Chylomicronemia Due to Mutations in Apolipoprotein CII: Apolipoprotein CII-Toronto and Apolipoprotein CII-St. Michael." In Human Apolipoprotein Mutants 2, 121–26. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4615-9549-6_15.

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Palmer, Julia E., and John A. Tidy. "Chapter 2 Management of cervical intraepithelial neoplasia (CIN)." In Vaccines for the Prevention of Cervical Cancer. Oxford University Press, 2008. http://dx.doi.org/10.1093/med/9780199543458.003.0002.

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Stöver, Bernd. "2. «Langley» als Institution." In CIA, 15–32. Verlag C.H.BECK oHG, 2017. http://dx.doi.org/10.17104/9783406704116-15.

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"Introduction to Part 2." In Quasi-Static State Analysis of Differential, Difference, Integral, and Gradient Systems, 85–87. Providence, Rhode Island: American Mathematical Society, 2010. http://dx.doi.org/10.1090/cln/021/05.

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Conference papers on the topic "CIN 2"

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Bark, V., A. Mondal, and M. Hampl. "Regressionsraten von CIN 2/CIN 3 bei Frauen unter 25 Jahren." In Kongressabstracts zur Tagung 2020 der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG). © 2020. Thieme. All rights reserved., 2020. http://dx.doi.org/10.1055/s-0040-1718120.

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Paspalj, V., S. Pils, R. Ristl, and E. Joura. "Metaanalyse zur HPV-Impfung nach Konisation und Rezidivrisiko für CIN 2+." In Kongressabstracts zur Wissenschaftlichen Tagung der Arbeitsgemeinschaft für gynäkologische Onkologie (AGO) der Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe (OEGGG). Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1681993.

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Siegler, E., O. Lavie, L. Mackuli, L. Ostrovsky, N. Kugelman, and Y. Segev. "EP402 Low Risk HPV types in CIN 2–3 and in invasive cervical cancer patients." In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.461.

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Kim, Mi Kyung, Sang Hoon Lee, Kyung-Jin Min, and Jae Kwan Lee. "Abstract 1888: HPV viral load and alcohol synergize to increase the risk of cervical intraepithelial neoplasia (CIN)1 in HPV positive women: Korean HPV Cohort Study." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-1888.

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Hillemanns, P., KU Petry, G. Böhmer, M. Jentschke, L. Wölber, I. Skjørestad, A. Frederiksen, and M. Axelsen. "P22 An exploratory safety and immunogenicity study of human papillomavirus (HPV16+) immunotherapy VB10.16 in women with high grade cervical intraepithelial neoplasia (HSIL; CIN 2/3)." In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.85.

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Park, JS, SJ Lee, SY Hur, TJ Kim, SR Hong, JK Lee, CH Cho, YS Suh, JW Woo, and YC Sung. "27 GX-188E, A therapeutic HPV vaccine, in combination with imiquimod or IL-7-HYFC for treatment of HPV-16 or HPV-18 related cin 3: results from phase 2 study." In IGCS Annual 2019 Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-igcs.27.

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Blayney, Douglas W., Lan Huang, and Ramon W. Mohanlal. "Abstract OT-06-02: Protective-2 (bpi-2358-106): A confirmatory trial to demonstrate superiority of the plinabulin+pegfilgrastim (plin/peg) combination versus standard of care pegfilgrastim for the prevention of chemotherapy-induced neutropenia (cin) in breast cancer (bc) patients (pts)." In Abstracts: 2020 San Antonio Breast Cancer Virtual Symposium; December 8-11, 2020; San Antonio, Texas. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.sabcs20-ot-06-02.

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Meyer, M., I. Schellenberg, B. Hofmann, and G. Vogel. "A GENETIC VARIANT OP PLATELET MEMBRANE GLYCOPROTEIN lb ASSOCIATED WITH A MILD BLEEDING DISORDER." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643510.

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Mild bleeding symptoms in a female patient were shown to be related to defective platelet function: Aggregation induced by ADP and PAP was decreased and platelet spreading was disturbed. Platelet membrane glycoproteins were analyzed by various electrophoretic procedures (SDS electrophoresis, nonreduced-reduced 2-dimensional and high resolution 2-dimensional electrophoresis). These studies revealed a decreased concentration of normal glycoprotein lb (GP Ib) and the appearance of an additional glycopeptide with an apparent Mr of 160.000 under reducing conditions. This component was strongly labeled in intact cells by periodate-3H-sodium borohydride. Staining characteristics of the additional glycopeptide were also similar to those of GP lb. Immunobiotting using a monospecific anti-glycocalicin antiserum provided conclusive evidence for a structural variant of GP lb molecularly characterized by an increase of about 20.000 in apparent Mp of the large subunit. The abnormal glycopeptide is cleaved by the endogenous calcium-dependent neutral protease and the resulting glycocali-cin exhibits the same increase in Mr as intact variant GP lb. The abnormal glycopeptide was also detected in 3 relatives of the proposita. All of the carriers are obviously heterozygous for the underlying mutant gene.
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Hillemanns, Peter, Karl Ulrich Petry, Linn Woelber, Gerd Böhmer, Elisabeth Stubsrud, Irene Skjørestad, Karoline Schjetne, Agnete Fredriksen, and Mads Axelsen. "Abstract CT209: Safety, efficacy and immunogenicity of VB10.16, a therapeutic DNA vaccine targeting human papillomavirus (HPV) 16 E6 and E7 proteins for high grade cervical intraepithelial neoplasia (CIN 2/3): 6-month data from an exploratory open-label phase I/2a trial." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-ct209.

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Hillemanns, Peter, Karl Ulrich Petry, Linn Woelber, Gerd Böhmer, Elisabeth Stubsrud, Irene Skjørestad, Karoline Schjetne, Agnete Fredriksen, and Mads Axelsen. "Abstract CT209: Safety, efficacy and immunogenicity of VB10.16, a therapeutic DNA vaccine targeting human papillomavirus (HPV) 16 E6 and E7 proteins for high grade cervical intraepithelial neoplasia (CIN 2/3): 6-month data from an exploratory open-label phase I/2a trial." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-ct209.

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Reports on the topic "CIN 2"

1

Eugene J Fine, Eugene J. Fine. Part 2: Can low carbohydrate ketogenic diets inhibit cancers? Experiment, July 2016. http://dx.doi.org/10.18258/7344.

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Lowell, Eini C., Daniel J. Parrent, Robert C. Deering, Dan Bihn, and Dennis R. Becker. Community biomass handbook. Volume 2: Alaska, where woody biomass can work. Portland, OR: U.S. Department of Agriculture, Forest Service, Pacific Northwest Research Station, 2015. http://dx.doi.org/10.2737/pnw-gtr-920.

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Aragon, K., and S. Denman. NWC (Nuclear Weapon Complex) CIM file header specification: Version 2. 0. Office of Scientific and Technical Information (OSTI), April 1990. http://dx.doi.org/10.2172/6799136.

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Eckman, Stephanie, Joe Eyerman, and Dorota Temple. Unmanned Aircraft Systems Can Improve Survey Data Collection. RTI Press, June 2018. http://dx.doi.org/10.3768/rtipress.2018.rb.0018.1806.

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Unmanned aircraft systems (UAS), or drones, will disrupt many industries in the next 5 to 10 years. In this research brief, we speculate about how UAS could be used in survey data collection to make survey data more accurate and/or less costly. We put forth three ideas for how UAS can be used to improve surveys in the future to (1) supplement survey data with UAS photo and sensor data; (2) deliver survey hardware to selected respondents, and (3) detect and enumerate housing units for sample selection.
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Dr. Ingrid Eisgruber. Manufacturable CuIn(Ga)Se{sub 2}-based solar cells via development of co-sputtered CuInSe{sub 2} absorber layers. Office of Scientific and Technical Information (OSTI), March 1999. http://dx.doi.org/10.2172/764593.

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Rus, Daniela, Erik Demaine, Ron Fearing, Ali Javey, Rob Wood, Vijay Kumar, and Mark Yim. Programmable Matter Creating Systems that Can Think, Talk, and Morph Autonomously. Phase 2. Fort Belvoir, VA: Defense Technical Information Center, September 2011. http://dx.doi.org/10.21236/ada584792.

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Smith, M. E. Phase 2 Can-in-Canister Cold Pour Tests for the Plutonium Immobilization Project. Office of Scientific and Technical Information (OSTI), December 2000. http://dx.doi.org/10.2172/768682.

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Eisgruber, I. L., J. R. Engel, R. Treece, and R. Hollingsworth. In-situ sensors for process control of CuIn(Ga)Se{sub 2}: Phase 2 Annual Report, February 1999 - February 2000. Office of Scientific and Technical Information (OSTI), June 2000. http://dx.doi.org/10.2172/757165.

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Trowbridge, L. D. Estimation of Flammability Limits of Selected Fluorocarbons with F(sub 2) and CIF(sub3). Office of Scientific and Technical Information (OSTI), September 1999. http://dx.doi.org/10.2172/12455.

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Desimone, David J., and Duc Ta Vo. Nondestructive Analysis of MET-5 Paint Can at TA35 Building 2 A-Wing Vault. Office of Scientific and Technical Information (OSTI), November 2016. http://dx.doi.org/10.2172/1331254.

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