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Journal articles on the topic 'CIN 2'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Crum, Christopher P. "Laboratory Management of CIN 2." American Journal of Clinical Pathology 130, no. 2 (2008): 162–64. http://dx.doi.org/10.1309/gcvb5c4kfv7tfc7f.

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2

Corona Gutierrez, Carlos Manuel, Alberto Tinoco, Tania Navarro, et al. "Therapeutic Vaccination with MVA E2 Can Eliminate Precancerous Lesions (CIN 1, CIN 2, and CIN 3) Associated with Infection by Oncogenic Human Papillomavirus." Human Gene Therapy 15, no. 5 (2004): 421–31. http://dx.doi.org/10.1089/10430340460745757.

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3

Mastutik, Gondo, Rahmi Alia, Alphania Rahniayu, Anny Setijo Rahaju, and Renny I’tishom. "Human pappilomavirus genotype in cervical tissue of patients with Cervical Intraepithelial Neoplasia (CIN) 1, CIN 2, and CIN 3." Majalah Obstetri & Ginekologi 24, no. 3 (2017): 74. http://dx.doi.org/10.20473/mog.v24i3.4568.

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Objectives: to determine the genotype of HPV in patients with precancerous lesions of cervical tissue.Materials and Methods: An observational study with cross sectional study of patients paraffin block CIN1, CIN2, CIN3 was conducted in Dr Soetomo Hospital. HPV DNA was extracted from paraffin blocks, then performed PCR and genotyping of HPV. The sample consisted of 28 patients with cervical tissue paraffin blocks CIN1, CIN2 and CIN3. Patients aged between 26-74 years (standard deviation 10,12).Results: HPV genotypes that infect patients with CIN1 were HPV16 and 18, CIN2 were HPV16 and 52 and CI

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Mastutik, Gondo, Rahmi Alia, Alphania Rahniayu, Anny Setijo Rahaju, Renny I’tishom, and Suhartono Taat Putra. "Human pappilomavirus genotype in cervical tissue of patients with Cervical Intraepithelial Neoplasia (CIN) 1, CIN 2, and CIN 3." Majalah Obstetri & Ginekologi 24, no. 3 (2018): 74. http://dx.doi.org/10.20473/mog.v24i32016.74-78.

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Objectives: to determine the genotype of HPV in patients with precancerous lesions of cervical tissue.Materials and Methods: An observational study with cross sectional study of patients paraffin block CIN1, CIN2, CIN3 was conducted in Dr Soetomo Hospital. HPV DNA was extracted from paraffin blocks, then performed PCR and genotyping of HPV. The sample consisted of 28 patients with cervical tissue paraffin blocks CIN1, CIN2 and CIN3. Patients aged between 26-74 years (standard deviation 10,12).Results: HPV genotypes that infect patients with CIN1 were HPV16 and 18, CIN2 were HPV16 and 52 and CI

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5

Katki, Hormuzd A., Mark Schiffman, Philip E. Castle, et al. "Five-Year Risk of Recurrence After Treatment of CIN 2, CIN 3, or AIS." Journal of Lower Genital Tract Disease 17 (April 2013): S78—S84. http://dx.doi.org/10.1097/lgt.0b013e31828543c5.

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6

Demarco, Maria, Thomas S. Lorey, Barbara Fetterman, et al. "Risks of CIN 2+, CIN 3+, and Cancer by Cytology and Human Papillomavirus Status." Journal of Lower Genital Tract Disease 21, no. 4 (2017): 261–67. http://dx.doi.org/10.1097/lgt.0000000000000343.

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7

Towler, Bernadette P., Les M. Irwig, and Julia M. Shelley. "The adequacy of management of women with CIN 2 and CIN 3 Pap smear abnormalities." Medical Journal of Australia 159, no. 8 (1993): 523–28. http://dx.doi.org/10.5694/j.1326-5377.1993.tb138005.x.

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8

Windrum, Graham. "The adequacy of management of women with CIN 2 and CIN 3 Pap smear abnormalities." Medical Journal of Australia 160, no. 3 (1994): 165–66. http://dx.doi.org/10.5694/j.1326-5377.1994.tb126581.x.

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9

Carcopino, X., C. Muszynski, J. L. Mergui, J. Gondry, and L. Boubli. "La CIN 2 merite-t-elle la même prise en charge que la CIN 3 ?" Gynécologie Obstétrique & Fertilité 39, no. 2 (2011): 94–99. http://dx.doi.org/10.1016/j.gyobfe.2010.11.001.

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10

Sykes, Peter, Carrie Innes, Dianne Harker, et al. "Observational Management of CIN 2 in Young Women." Journal of Lower Genital Tract Disease 20, no. 4 (2016): 343–47. http://dx.doi.org/10.1097/lgt.0000000000000244.

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11

K, Kalpanadevi, and Sinduja C.R. "SYNTHESIS, CHARACTERISATION AND BIOLOGICAL STUDIES OF [M(CIN)2(N2H4)2] (M=NI/CD)." Kongunadu Research Journal 1, no. 1 (2014): 42–45. http://dx.doi.org/10.26524/krj10.

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12

Babkina, N., D. Heller, L. Goldsmith, and K. Houck. "Abstract 16: Outcome after cervical conization for CIN 2 or CIN 3 in HIV-positive women." Gynecologic Oncology 131, no. 1 (2013): 285. http://dx.doi.org/10.1016/j.ygyno.2013.04.046.

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13

Souza, Carlos, Michelle Discacciati, Maria d'Otavianno, et al. "Underdiagnosis of cervical intraepithelial neoplasia (CIN) 2 or Worse Lesion in Women with a Previous Colposcopy-Guided Biopsy Showing CIN 1." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 39, no. 03 (2017): 123–27. http://dx.doi.org/10.1055/s-0037-1599071.

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Objective Expectant follow-up for biopsy-proven cervical intraepithelial neoplasia (CIN) 1 is the current recommendation for the management of this lesion. Nevertheless, the performance of the biopsy guided by colposcopy might not be optimal. Therefore, this study aimed to calculate the rate of underdiagnoses of more severe lesions in women with CIN 1 diagnosis and to evaluate whether age, lesion extent and biopsy site are factors associated with diagnostic failure. Methods Eighty women with a diagnosis of CIN 1 obtained by colposcopy-guided biopsy were selected for this study. These women wer

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14

Austin, Robert Marshall. "ATHENA Trial CIN 2+ Cervical Biopsy Misclassifications Raise Questions." American Journal of Clinical Pathology 137, no. 6 (2012): 1012.1–1012. http://dx.doi.org/10.1309/ajcpmrvtj8ip1lwh.

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15

Fonseca-Moutinho, J. A., E. Cruz, L. Carvalho, et al. "Estrogen receptor, progesterone receptor, and bcl-2 are markers with prognostic significance in CIN III." International Journal of Gynecologic Cancer 14, no. 5 (2004): 911–20. http://dx.doi.org/10.1136/ijgc-00009577-200409000-00026.

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There are no known biological markers or technologies to predict the natural history of an individual CIN III. The probability of progression is considered greater with the persistence of high-risk human papillomavirus (HPV) infection and age. p53 polymorphism has been associated with cervical carcinogenesis. Hormone-induced cervical cancer is mediated by estrogen receptor (ER) and progesterone receptor (PR). In cervical cancer, increased bcl-2 and Bax immunoreactivity is generally associated with a better prognosis. The purpose of this study was to evaluate the value of HPV 16 and HPV 18 typi

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16

Wesełucha-Birczyńska, A., B. Oleksyn, C. Paluszkiewicz, and J. Śliwiński. "X-ray and vibrational temperature dependence investigations of [(cin H2)2+(CuCl4)2−]2·3H2O." Journal of Molecular Structure 511-512 (November 1999): 301–5. http://dx.doi.org/10.1016/s0022-2860(99)00172-6.

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17

Schwarz, Tino F. "Signifikant weniger CIN-Läsionen durch HPV-Impfprogramm." gynäkologie + geburtshilfe 20, no. 1 (2015): 15. http://dx.doi.org/10.1007/s15013-015-0613-2.

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18

TER HARMSEL, BRAM, FRANK SMEDTS, JOHAN KUIJPERS, MARCEL JEUNINK, BAPTIST TRIMBOS, and FRANS RAMAEKERS. "BCL-2 IMMUNOREACTIVITY INCREASES WITH SEVERITY OF CIN: A STUDY OF NORMAL CERVICAL EPITHELIA, CIN, AND CERVICAL CARCINOMA." Journal of Pathology 179, no. 1 (1996): 26–30. http://dx.doi.org/10.1002/(sici)1096-9896(199605)179:1<26::aid-path516>3.0.co;2-e.

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19

Lubrano, Amina, Norberto Medina, Virginia Benito, et al. "Follow-up after LLETZ: a study of 682 cases of CIN 2–CIN 3 in a single institution." European Journal of Obstetrics & Gynecology and Reproductive Biology 161, no. 1 (2012): 71–74. http://dx.doi.org/10.1016/j.ejogrb.2011.11.023.

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20

Gonzalez-Bosquet, Eduardo, Monica Gibert, Mariona Serra, Alicia Hernandez-Saborit, and Alba Gonzalez-Fernandez. "Candidate HPV genotypes not included in the 9-valent vaccine for prevention of CIN 2–3." International Journal of Gynecologic Cancer 30, no. 7 (2020): 954–58. http://dx.doi.org/10.1136/ijgc-2019-001069.

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ObjectivesTo identify the prevalence of human papillomavirus genotypes – as a single infection or co-infection – not included in the 9-valent (9v) HPV vaccine among women with cervical intraepithelial neoplasia (CIN 2–3).MethodsRetrospective study of 1700 women referred due to abnormal cytology to Sant Joan de Deu Hospital. We selected 849 patients with CIN 2 or CIN 3 diagnosis confirmed by biopsy. An HPV test, a second cytology, and colposcopy were performed on all patients.Those with abnormal colposcopy underwent cervical biopsy. Patients with abnormal cytology and normal colposcopy or trans

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21

NELSON, ROXANNE. "Physicians Debate Conservative Versus Aggressive Treatment of CIN 2 Lesions." Family Practice News 36, no. 13 (2006): 40. http://dx.doi.org/10.1016/s0300-7073(06)73469-7.

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22

Mayer, R., and A. K. Müller. "1-Thiol-3-selenol-thion-(2), cin neuer Heterocyclus [1]." Zeitschrift für Chemie 4, no. 10 (2010): 384. http://dx.doi.org/10.1002/zfch.19640041007.

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23

Reich, Olaf, and Sigrid Regauer. "Initial diagnosis of CIN 2–should patients be managed expectatively?" American Journal of Obstetrics and Gynecology 206, no. 3 (2012): e11. http://dx.doi.org/10.1016/j.ajog.2011.11.003.

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24

Rodolakis, A., J. Biliatis, and N. Thomakos. "Chromosome 3q26 gain for identification of women less likely to progress from LSIL/CIN 1 to HSIL/≥CIN 2." Gynecologic Oncology 120 (March 2011): S106. http://dx.doi.org/10.1016/j.ygyno.2010.12.251.

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25

Inada, Natalia Mayumi, Hilde Harb Buzzá, Marieli Fernanda Martins Leite, et al. "Long Term Effectiveness of Photodynamic Therapy for CIN Treatment." Pharmaceuticals 12, no. 3 (2019): 107. http://dx.doi.org/10.3390/ph12030107.

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(1) Background: Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in women worldwide. The highest incidence rates are in Africa, followed by South-Central Asia and South America. According to the Brazilian National Institute of Cancer (INCA), 16,370 new cases of cervical cancer were estimated for each year of the biennium of 2018–2019. About 90% of cervical cancers originate from the malignant progression of cervical intraepithelial neoplasia (CIN) which is classified based on cytohistological characteristics (low- and high-grade lesions).

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26

Pierry, Deirdre, Gerald Weiss, Benjamin Lack, Victor Chen, and Judy Fusco. "Intracellular Human Papillomavirus E6, E7 mRNA Quantification Predicts CIN 2+ in Cervical Biopsies Better Than Papanicolaou Screening for Women Regardless of Age." Archives of Pathology & Laboratory Medicine 136, no. 8 (2012): 956–60. http://dx.doi.org/10.5858/arpa.2011-0180-oa.

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Context.—Cervical cancer screening in women younger than 30 years relies on cervical cytology because of the poor performance of human papillomavirus (HPV) DNA testing in this age group. Objectives.—To determine the performance of in-cell HPV E6, E7 mRNA quantification (HPV OncoTect) for the detection of high-grade cervical intraepithelial neoplasia in women younger than 30 years. Design.—We analyzed 3133 cytology specimens from a screening population of women aged 19–75 years investigate HPV OncoTect as a triage/secondary screening test for atypical squamous cells of undetermined significance

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27

Gashi, Goneta, Elton Bahtiri, Arjeta Podrimaj-Bytyqi, et al. "Genomic instability in peripheral blood lymphocytes of patients diagnosed with high-grade squamous intraepithelial lesions: CIN 2 versus CIN 3." Mutation Research/Genetic Toxicology and Environmental Mutagenesis 854-855 (June 2020): 503202. http://dx.doi.org/10.1016/j.mrgentox.2020.503202.

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28

Katki, Hormuzd A., Mark Schiffman, Philip E. Castle, et al. "Five-Year Risks of CIN 2+ and CIN 3+ Among Women With HPV-Positive and HPV-Negative LSIL Pap Results." Journal of Lower Genital Tract Disease 17 (April 2013): S43—S49. http://dx.doi.org/10.1097/lgt.0b013e3182854269.

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29

Arends, Mark J., Yvonne K. Donaldson, Edward Duvall, Andrew H. Wyllie, and Colin C. Bird. "HPV in full thickness cervical biopsies: High prevalence in CIN 2 and CIN 3 detected by a sensitive PCR method." Journal of Pathology 165, no. 4 (1991): 301–9. http://dx.doi.org/10.1002/path.1711650405.

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30

Loobuyek, Henk A., and Ian D. Duncan. "Destruction of CIN 1 and 2 With the Semm Cold Coagulator." Obstetrical & Gynecological Survey 49, no. 2 (1994): 113. http://dx.doi.org/10.1097/00006254-199402000-00018.

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31

Nygård, Jan F., Torill Sauer, Finn Egil Skjeldestad, Gry Baadstr, Skare NIL, and Steinar Østerbø Thoresen. "CIN 2/3 and Cervical Cancer After an ASCUS Pap Smear." Acta Cytologica 47, no. 6 (2003): 991–1000. http://dx.doi.org/10.1159/000326673.

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32

Cullimore, J. E., C. B. J. Woodman, D. M. Luesley, J. A. Jordan, and P. Byrne. "WHEN LASER VAPORISATION FOR CIN FAILS, WHAT NEXT?" Lancet 333, no. 8637 (1989): 561–62. http://dx.doi.org/10.1016/s0140-6736(89)90106-2.

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33

KAPETANIOS, V., A. C. LAZARIS, P. BOGRIS, et al. "Extracellular regulated kinase-2 immunoreactivity increases in parallel with cervical intraepithelial neoplasia grade in cervical neoplasia." International Journal of Gynecologic Cancer 18, no. 3 (2008): 540–45. http://dx.doi.org/10.1111/j.1525-1438.2007.01057.x.

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The cell cycle control system includes cyclins, cyclin-dependent kinases (CDK), and their inhibitors (CDK1). Extracellular regulated kinase (ERK1/2) (p44 and p42 mitogen-activated protein kinases [MAPKs]) is a component of the MAPK pathway, which is associated with cyclin D1 and CDK. It is a critical signaling system for the induction of cell proliferation, differentiation, and cell survival. The aim of this study was to investigate the usefulness of ERK2 expression as a marker of biological aggressiveness complementary to cervical intraepithelial neoplasia (CIN) grade as well as to compare it

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34

Lee, Yoon Hee, Gi-Ung Kang, Se Young Jeon, et al. "Vaginal Microbiome-Based Bacterial Signatures for Predicting the Severity of Cervical Intraepithelial Neoplasia." Diagnostics 10, no. 12 (2020): 1013. http://dx.doi.org/10.3390/diagnostics10121013.

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Although emerging evidence revealed that the gut microbiome served as a tool and as biomarkers for predicting and detecting specific cancer or illness, it is yet unknown if vaginal microbiome-derived bacterial markers can be used as a predictive model to predict the severity of CIN. In this study, we sequenced V3 region of 16S rRNA gene on vaginal swab samples from 66 participants (24 CIN 1−, 42 CIN 2+ patients) and investigated the taxonomic composition. The vaginal microbial diversity was not significantly different between the CIN 1− and CIN 2+ groups. However, we observed Lactobacillus amy

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35

Altintop, Ismail, Mehmet Tatli, Cigdem Karakukcu, et al. "Serum and Tissue HIF-2 Alpha Expression in CIN, N-Acetyl Cysteine, and Sildenafil-Treated Rat Models: An Experimental Study." Medicina 54, no. 4 (2018): 54. http://dx.doi.org/10.3390/medicina54040054.

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Background and Objectives: Contrast-induced nephropathy (CIN), is acute renal damage due to contrast agents. This study is conducted to evaluate serum and renal heterodimeric nuclear transcription factor (HIF)-2 alpha levels and its tissue expression in contrast-induced nephropathy, and in N-acetyl cysteine (NAC)-and Sildenafil-treated rat models. Materials/Methods: This randomized, controlled, interventional animal study was conducted on Wistar rats. Rats (n = 36) were randomly assigned to four groups: control (n = 9), CIN group (n = 9), CIN + NAC group (n = 9), and sildenafil (n = 9). The ra

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36

Duggan, M�ire A., and Penny M. A. Brasher. "Accuracy of Pap tests reported as CIN I." Diagnostic Cytopathology 21, no. 2 (1999): 129–36. http://dx.doi.org/10.1002/(sici)1097-0339(199908)21:2<129::aid-dc10>3.0.co;2-m.

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37

Geng, L. "P534 Subsequent risk and presentation of cervical intraepithelial neoplasia (CIN) 2/3 after a colposcopic diagnosis of CIN 1 or less." International Journal of Gynecology & Obstetrics 107 (October 2009): S564—S565. http://dx.doi.org/10.1016/s0020-7292(09)62024-5.

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38

García-Hernández, E., J. L. González-Sánchez, A. Andrade-Manzano, et al. "Regression of papilloma high-grade lesions (CIN 2 and CIN 3) is stimulated by therapeutic vaccination with MVA E2 recombinant vaccine." Cancer Gene Therapy 13, no. 6 (2006): 592–97. http://dx.doi.org/10.1038/sj.cgt.7700937.

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39

Loffredo D’Ottaviano, Maria Gabriela, Michelle Garcia Discacciati, Maria Antonieta Andreoli, et al. "HPV 16 Is Related to the Progression of Cervical Intraepithelial Neoplasia Grade 2: A Case Series." Obstetrics and Gynecology International 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/328909.

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Purpose. To describe the acquisition, persistence, and clearance of HPV infection in women with CIN 2 followed up for 12 months.Methods. Thirty-seven women with CIN 2 biopsy, who have proven referral to cervical smear showing low-grade squamous intraepithelial lesions or atypical squamous cells of undetermined significance and tested for HPV, were followed up for one year with cervical smear, colposcopy, and HPV test every three months. HPV DNA was detected by the polymerase chain reaction and genotyping by reverse line blot hybridization assay.Results. CIN 2 regression rate was 49% (18/37), p

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40

Kooiman, Thea J. M., Martijn de Groot, Klaas Hoogenberg, Wim P. Krijnen, Cees P. van der Schans, and Adriaan Kooy. "Self-tracking of Physical Activity in People With Type 2 Diabetes." CIN: Computers, Informatics, Nursing 36, no. 7 (2018): 340–49. http://dx.doi.org/10.1097/cin.0000000000000443.

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41

Burns, Pippa, Judy Mullan, Robyn Gillespie, et al. "Evaluating the Managing Medicines for People With Dementia Website Version 2." CIN: Computers, Informatics, Nursing 37, no. 1 (2019): 47–54. http://dx.doi.org/10.1097/cin.0000000000000475.

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42

Lan, Jingqiu, and Genji Qin. "The Regulation of CIN-like TCP Transcription Factors." International Journal of Molecular Sciences 21, no. 12 (2020): 4498. http://dx.doi.org/10.3390/ijms21124498.

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TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR 1 and 2 (TCP) family proteins are the plant-specific transcription factors extensively participating in diverse developmental processes by integrating external cues with internal signals. The roles of CINCINNATA (CIN)-like TCPs are conserved in control of the morphology and size of leaves, petal development, trichome formation and plant flowering. The tight regulation of CIN-like TCP activity at transcriptional and post-transcriptional levels are central for plant developmental plasticity in response to the ever-changing environmental cond

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43

Edridge, William. "Recurrence of CIN 2 and 3 after treatment in HIV positive patients." American Journal of Obstetrics and Gynecology 219, no. 2 (2018): 216–17. http://dx.doi.org/10.1016/j.ajog.2018.04.019.

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44

Umphress, Brandon, Beatriz Sanchez, Ajit Paintal, Ritu Nayar, and Kruti P. Maniar. "Utility of CK7 Versus p16 as a Prognostic Biomarker in CIN 2." American Journal of Surgical Pathology 42, no. 4 (2018): 479–84. http://dx.doi.org/10.1097/pas.0000000000001032.

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45

Rodolakis, A., E. Diakomanolis, D. Haidopoulos, G. Vlachos, and S. Michalas. "CONSERVATIVE MANAGEMENT OF CERVICAL INTRAEPITHELIAL NEOPLASIA (CIN 2–3) IN PREGNANT WOMEN." International Journal of Gynecologic Cancer 13, Suppl 1 (2003): 34.2–35. http://dx.doi.org/10.1136/ijgc-00009577-200303001-00118.

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FITZGERALD, SHARON A., ALEJANDRO GUTIERREZ OCAMPO, KENIA YAZMIN REYNA BLANCO, VIRGINIA LEWIS, A. PAULA CUPERTINO, and EDWARD F. ELLERBECK. "Addressing the Needs of Latinos With Type 2 Diabetes Through Online Patient Education." CIN: Computers, Informatics, Nursing 32, no. 9 (2014): 451–57. http://dx.doi.org/10.1097/cin.0000000000000091.

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47

Peremislov, Diana. "Patient Use of the Electronic Communication Portal in Management of Type 2 Diabetes." CIN: Computers, Informatics, Nursing 35, no. 9 (2017): 473–82. http://dx.doi.org/10.1097/cin.0000000000000348.

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48

Sverdlova, E. S., and T. V. Dianova. "Features of papillomavirus infection in HIV-infected women." Epidemiology and Infectious Diseases 17, no. 4 (2012): 9–11. http://dx.doi.org/10.17816/eid40631.

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As participation of immune system in the protection of human papillomavirus (HPV) has been proven, the incidence of HPV infection leading to cervical intraepithelial neoplasia (CIN) among HIV-positive women is 4 times higher than in HIV-negative cases. In the presence of HIV HPV implements oncoprogram during 6-12 months. Сytokine imbalance makes a significant contribution to the progression of HIV in combination with HPV. The criteria of selection of patients with HIV for therapy cytokines in CIN 2-3 (Roncoleukin used in the author's scheme). Using Ronkoleukin in combination with HAART in HIV-

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49

Weese, J., P. D. Sandhu, A. Mody, et al. "Assessment of diabetes mellitus (DM) as a risk factor for development of cisplatin-induced nephrotoxicity (CIN)." Journal of Clinical Oncology 27, no. 15_suppl (2009): e13537-e13537. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e13537.

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e13537 Background: DM is the most common cause of kidney disease in the US, and it may increase the risk of CIN. In vivo studies however suggest that DM not only is not a risk factor for CIN, it may even be protective. This may be explained by dysfunction of organic cation transporter-2, the critical transporter for cisplatin uptake in proximal tubules, in diabetic kidneys. We conducted a case-control study to assess the relationship between DM and CIN. Methods: Records of all patients (pts) who received cisplatin between 1/1/00 and 12/31/06 at Oklahoma City VA Hospital were reviewed. DM was d

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50

Discacciati, Michelle G., Ismael DCG da Silva, Luisa L. Villa, et al. "Prognostic Value of DNA and mRNA E6/E7 of Human Papillomavirus in the Evolution of Cervical Intraepithelial Neoplasia Grade 2." Biomarker Insights 9 (January 2014): BMI.S14296. http://dx.doi.org/10.4137/bmi.s14296.

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Objective This study aimed at evaluating whether human papillomavirus (HPV) groups and E6/E7 mRNA of HPV 16, 18, 31, 33, and 45 are prognostic of cervical intraepithelial neoplasia (CIN) 2 outcome in women with a cervical smear showing a low-grade squamous intraepithelial lesion (LSIL). Methods This cohort study included women with biopsy-confirmed CIN 2 who were followed up for 12 months, with cervical smear and colposcopy performed every three months. Results Women with a negative or low-risk HPV status showed 100% CIN 2 regression. The CIN 2 regression rates at the 12-month follow-up were 6

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