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Journal articles on the topic 'CIN1'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Hoyt, M. Andrew, Jennifer P. Macke, B. Tibor Roberts, and John R. Geiser. "Saccharomyces cerevisiae PAC2 Functions With CIN1, 2 and 4 in a Pathway Leading to Normal Microtubule Stability." Genetics 146, no. 3 (1997): 849–57. http://dx.doi.org/10.1093/genetics/146.3.849.

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The products of the Saccharomyces cerevisiae CIN1, CIN2 and CIN4 genes participate in a nonessential pathway required for normal microtubule function. In this article, we demonstrate that the product of PAC2 also functions in this pathway. PAC2 deletion mutants displayed phenotypes and genetic interactions similar to those caused by cin1Δ, cin2Δ and cin4Δ. These include cold-sensitive microtubule structures and sensitivity to the microtubule depolymerizing agent benomyl. Involvement in a common functional pathway is indicated by the observation that all double mutant combinations are viable an

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Mastutik, Gondo, Rahmi Alia, Alphania Rahniayu, Anny Setijo Rahaju, and Renny I’tishom. "Human pappilomavirus genotype in cervical tissue of patients with Cervical Intraepithelial Neoplasia (CIN) 1, CIN 2, and CIN 3." Majalah Obstetri & Ginekologi 24, no. 3 (2017): 74. http://dx.doi.org/10.20473/mog.v24i3.4568.

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Objectives: to determine the genotype of HPV in patients with precancerous lesions of cervical tissue.Materials and Methods: An observational study with cross sectional study of patients paraffin block CIN1, CIN2, CIN3 was conducted in Dr Soetomo Hospital. HPV DNA was extracted from paraffin blocks, then performed PCR and genotyping of HPV. The sample consisted of 28 patients with cervical tissue paraffin blocks CIN1, CIN2 and CIN3. Patients aged between 26-74 years (standard deviation 10,12).Results: HPV genotypes that infect patients with CIN1 were HPV16 and 18, CIN2 were HPV16 and 52 and CI

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Mastutik, Gondo, Rahmi Alia, Alphania Rahniayu, Anny Setijo Rahaju, Renny I’tishom, and Suhartono Taat Putra. "Human pappilomavirus genotype in cervical tissue of patients with Cervical Intraepithelial Neoplasia (CIN) 1, CIN 2, and CIN 3." Majalah Obstetri & Ginekologi 24, no. 3 (2018): 74. http://dx.doi.org/10.20473/mog.v24i32016.74-78.

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Objectives: to determine the genotype of HPV in patients with precancerous lesions of cervical tissue.Materials and Methods: An observational study with cross sectional study of patients paraffin block CIN1, CIN2, CIN3 was conducted in Dr Soetomo Hospital. HPV DNA was extracted from paraffin blocks, then performed PCR and genotyping of HPV. The sample consisted of 28 patients with cervical tissue paraffin blocks CIN1, CIN2 and CIN3. Patients aged between 26-74 years (standard deviation 10,12).Results: HPV genotypes that infect patients with CIN1 were HPV16 and 18, CIN2 were HPV16 and 52 and CI

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Hoyt, M. A., T. Stearns, and D. Botstein. "Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes." Molecular and Cellular Biology 10, no. 1 (1990): 223–34. http://dx.doi.org/10.1128/mcb.10.1.223-234.1990.

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By using a multiply marked supernumerary chromosome III as an indicator, we isolated mutants of Saccharomyces cerevisiae that display increased rates of chromosome loss. In addition to mutations in the tubulin-encoding TUB genes, we found mutations in the CIN1, CIN2, and CIN4 genes. These genes have been defined independently by mutations causing benomyl supersensitivity and are distinct from other known yeast genes that affect chromosome segregation. Detailed phenotypic characterization of cin mutants revealed several other phenotypes similar to those of tub mutants. Null alleles of these gen

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Hoyt, M. A., T. Stearns, and D. Botstein. "Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes." Molecular and Cellular Biology 10, no. 1 (1990): 223–34. http://dx.doi.org/10.1128/mcb.10.1.223.

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By using a multiply marked supernumerary chromosome III as an indicator, we isolated mutants of Saccharomyces cerevisiae that display increased rates of chromosome loss. In addition to mutations in the tubulin-encoding TUB genes, we found mutations in the CIN1, CIN2, and CIN4 genes. These genes have been defined independently by mutations causing benomyl supersensitivity and are distinct from other known yeast genes that affect chromosome segregation. Detailed phenotypic characterization of cin mutants revealed several other phenotypes similar to those of tub mutants. Null alleles of these gen

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Panjkovic, Milana, and Tatjana Ivkovic-Kapicl. "Ki-67 expression in squamous intraepithelial lesions of the uterine cervix." Archive of Oncology 14, no. 1-2 (2006): 23–25. http://dx.doi.org/10.2298/aoo0602023p.

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BACKGROUND: Uncontrolled cell proliferation and malignant transformation are the basic elements in the development of malignant disease including cervical cancer and its precursors. The aim of this study was to investigate the proliferative activity by using Ki-67 proliferative marker according to CIN grade. METHODS: We used immunohistochemical methods to study the expression of the proliferative marker Ki-67 in the specimens of 5 patients with normal cervical epithelium, 7 with CIN1, 13 with CIN2, and 25 patients with CIN3 grade of the cervical intraepithelial lesions. RESULTS: All cases with

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Dushkin, A. D., M. S. Afanasiev, A. M. Zatevalov, et al. "Digital analysis and quantitative assessment of the cervical surface with dysplasia." Russian Clinical Laboratory Diagnostics 66, no. 7 (2021): 417–21. http://dx.doi.org/10.51620/0869-2084-2021-66-7-417-421.

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The investigation aims - a quantitative assessment of cervical surface changes with digital analysis and computer technologies in dysplasia. Colposcopy was made in 90 women from 21 to 52 years (avr. age 33,9±8,13 y.o.) with mild epithelial dysplasia (CIN1), moderate dysplasia (CIN2), severe dysplasia (CIN3). The algorithm detected indicators which provide the cervical dysplasia classification on pre cytological and pre molecular-genetic patients investigations. The outcome of an algorithm was the identification of the cervix surface condition severity by an objective quantification. The cervic

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Triratanachat, S., S. Niruthisard, P. Trivijitsilp, D. Tresukosol, and N. Jarurak. "Angiogenesis in cervical intraepithelial neoplasia and early-staged uterine cervical squamous cell carcinoma: clinical significance." International Journal of Gynecologic Cancer 16, no. 2 (2006): 575–80. http://dx.doi.org/10.1136/ijgc-00009577-200603000-00017.

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The objective of this study is to evaluate angiogenesis in cervical intraepithelial neoplasia (CIN), microinvasive squamous cell carcinoma (MIC), and early-staged squamous cell carcinoma (SCC), stage IB–IIA of the cervix. Microvessel density (MVD) was evaluated and correlated with other pathologic prognostic factors and disease outcomes. Four hundred seventy-four cervical specimens were studied. Among these, 100 were designated normal cervix, 30 CIN1, 32 CIN2, 178 CIN3, 74 MIC, and 60 early-staged SCC. MVD per high-power field (×400) of early-staged SCC, MIC, and CIN3 were significantly higher

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Ishikawa, M., T. Fujii, M. Saito, et al. "Overexpression of p16^INK4aas an indicator for human papillomavirus oncogenic activity in cervical squamous neoplasia." International Journal of Gynecologic Cancer 16, no. 1 (2006): 347–53. http://dx.doi.org/10.1136/ijgc-00009577-200601000-00056.

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Overexpression of p16INK4ahas been observed when retinoblastoma protein is inactivated by high-risk human papillomavirus (HPV) oncoprotein E7. We investigated overexpression of p16INK4aand HPV infection in cervical squamous neoplasia to evaluate the oncogenic potential among various HPV subtypes. The high-risk HPV was detected by PCR in 69.8% (37/53), 97.5% (39/40), 91.7% (44/48), and 100% (16/16) of cervical intraepithelial neoplasia (CIN)1, CIN2, CIN3, and squamous cell carcinoma (SCC), respectively. The p16INK4aoverexpression was investigated immunohistochemically using a p16INK4a-specific

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Salazar-Piña, Azucena, Minerva Maldonado-Gama, Ana M. Gonzalez-Jaimes, et al. "Serum Antibodies Against the E5 Oncoprotein from Human Papillomavirus Type 16 Are Inversely Associated with the Infection and the Degree of Cervical Lesions." Biomedicines 12, no. 12 (2024): 2699. http://dx.doi.org/10.3390/biomedicines12122699.

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Background: The humoral immune response against human papillomavirus (HPV) has been suggested as a source of biomarkers for the early detection of cervical cancer (CC). Therefore, we aimed to characterize the antibody response against HPV16 E5 in the natural history of cervical cancer and to determine its usefulness as a biomarker of HPV-associated cervical lesions. Methods: This study was conducted at the Cuautla General Hospital, Morelos, Mexico, with women (18 to 64 years) who agreed to participate. Samples were obtained from 335 women with cervical lesions and 150 women with negative Papan

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Baasland, Ingrid, Tone Bjørge, Birgit Engesæter, Ameli Tropé, and Signe Opdahl. "Cervical intraepithelial neoplasia grade 1 and long-term risk of progression and treatment." PLOS One 20, no. 4 (2025): e0320739. https://doi.org/10.1371/journal.pone.0320739.

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Background Cervical intraepithelial neoplasia grade 1 (CIN1) is often managed by active surveillance, as the risk of progression to high grade lesions is reported to be low, but long-term data is sparse. To inform management of CIN1, we estimated risk of progression and occurrence of treatment in women attending a cervical cancer screening program. Methods We used nationwide, registry data on all women aged 25–69 years attending the Norwegian Cervical Cancer Screening Program in 2002–2019. The eligible source population was women with at least one cytology registration (n = 1,771,876). Women w

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Payano, Victor Jesus Huaringa, Lara Verônica de Araújo Lopes, Larissa Rodrigues Peixoto та ін. "Immunostaining of βA-Activin and Follistatin Is Decreased in HPV(+) Cervical Pre-Neoplastic and Neoplastic Lesions". Viruses 15, № 5 (2023): 1031. http://dx.doi.org/10.3390/v15051031.

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The activin–follistatin system regulates several cellular processes, including differentiation and tumorigenesis. We hypothesized that the immunostaining of βA-activin and follistatin varies in neoplastic cervical lesions. Cervical paraffin-embedded tissues from 162 patients sorted in control (n = 15), cervical intraepithelial neoplasia (CIN) grade 1 (n = 38), CIN2 (n = 37), CIN3 (n = 39), and squamous cell carcinoma (SCC; n = 33) groups were examined for βA-activin and follistatin immunostaining. Human papillomavirus (HPV) detection and genotyping were performed by PCR and immunohistochemistr

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Taguchi, Ayumi, Konan Hara, Jun Tomio, et al. "Multistate Markov Model to Predict the Prognosis of High-Risk Human Papillomavirus-Related Cervical Lesions." Cancers 12, no. 2 (2020): 270. http://dx.doi.org/10.3390/cancers12020270.

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Cervical intraepithelial neoplasia (CIN) has a natural history of bidirectional transition between different states. Therefore, conventional statistical models assuming a unidirectional disease progression may oversimplify CIN fate. We applied a continuous-time multistate Markov model to predict this CIN fate by addressing the probability of transitions between multiple states according to the genotypes of high-risk human papillomavirus (HPV). This retrospective cohort comprised 6022 observations in 737 patients (195 normal, 259 CIN1, and 283 CIN2 patients at the time of entry in the cohort).

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Vogel, John P., Peter Schuerman, Keith Woeste, Ingrid Brandstatter, and Joseph J. Kieber. "Isolation and Characterization of Arabidopsis Mutants Defective in the Induction of Ethylene Biosynthesis by Cytokinin." Genetics 149, no. 1 (1998): 417–27. http://dx.doi.org/10.1093/genetics/149.1.417.

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Abstract Cytokinins elevate ethylene biosynthesis in etiolated Arabidopsis seedlings via a post-transcriptional modification of one isoform of the key biosynthetic enzyme ACC synthase. In order to begin to dissect the signaling events leading from cytokinin perception to this modification, we have isolated a series of mutants that lack the ethylene-mediated triple response in the presence of cytokinin due to their failure to increase ethylene biosynthesis. Analysis of genetic complementation and mapping revealed that these Cin mutants (cytokinin-insensitive) represent four distinct complementa

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Kruse, Arnold-Jan, Jan P. A. Baak, Emiel A. Janssen, et al. "Ki67 Predicts Progression in Early CIN: Validation of a Multivariate Progression-Risk Model." Analytical Cellular Pathology 26, no. 1-2 (2004): 13–20. http://dx.doi.org/10.1155/2004/108305.

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This study of early CIN biopsies (25 CIN1 and 65 CIN2) with long follow-up was done to validate, in a new group of patients, the value of Ki67 immuno-quantitative features to predict high CIN grade in a follow-up biopsy (often denoted to as “progression”), as described in a previous study. Each biopsy in the present study was classified with the previously described Ki67-model (consisting of the stratification index and the % positive nuclei in the middle third layer of the epithelium) as “low-risk” or “high-risk”, and matched with the follow-up outcome (progression-or-not). Furthermore, it wa

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Sideri, Mario, Paola Garutti, Silvano Costa, et al. "Accuracy of Colposcopically Directed Biopsy: Results from an Online Quality Assurance Programme for Colposcopy in a Population-Based Cervical Screening Setting in Italy." BioMed Research International 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/614035.

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Purpose. To report the accuracy of colposcopically directed biopsy in an internet-based colposcopy quality assurance programme in northern Italy.Methods. A web application was made accessible on the website of the regional Administration. Fifty-nine colposcopists out of the registered 65 logged in, viewed a posted set of 50 digital colpophotographs, classified them for colposcopic impression and need for biopsy, and indicated the most appropriate site for biopsy with a left-button mouse click on the image.Results. Total biopsy failure rate, comprising both nonbiopsy and incorrect selection of

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Correa, Rita Mariel, Armando Baena, Joan Valls, et al. "Distribution of human papillomavirus genotypes by severity of cervical lesions in HPV screened positive women from the ESTAMPA study in Latin America." PLOS ONE 17, no. 7 (2022): e0272205. http://dx.doi.org/10.1371/journal.pone.0272205.

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The proportion of HPV16 and 18-associated cervical cancer (CC) appears rather constant worldwide (≥70%), but the relative importance of the other HR-HPV differs slightly by geographical region. Here, we studied the HPV genotype distribution of HPV positive Latin American (LA) women by histological grade, in a sub-cohort from the ESTAMPA study; we also explored the association of age-specific HPV genotypes in severe lesions. Cervical samples from 1,252 participants (854 ≤CIN1, 121 CIN2, 194 CIN3 and 83 CC) were genotyped by two PCRs-Reverse Blotting Hybridization strategies: i) Broad-Spectrum G

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Fleming, James A., Leticia R. Vega, and Frank Solomon. "Function of Tubulin Binding Proteins in Vivo." Genetics 156, no. 1 (2000): 69–80. http://dx.doi.org/10.1093/genetics/156.1.69.

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Abstract Overexpression of the β-tubulin binding protein Rbl2p/cofactor A is lethal in yeast cells expressing a mutant α-tubulin, tub1-724, that produces unstable heterodimer. Here we use RBL2 overexpression to identify mutations in other genes that affect formation or stability of heterodimer. This approach identifies four genes—CIN1, CIN2, CIN4, and PAC2—as affecting heterodimer formation in vivo. The vertebrate homologues of two of these gene products—Cin1p/cofactor D and Pac2p/cofactor E—can catalyze exchange of tubulin polypeptides into preexisting heterodimer in vitro. Previous work sugg

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Slavkovsky, Rose C., Pooja Bansil, Manuel A. Sandoval, et al. "Health Outcomes at 1 Year After Thermal Ablation for Cervical Precancer Among Human Papillomavirus– and Visual Inspection With Acetic Acid–Positive Women in Honduras." JCO Global Oncology, no. 6 (October 2020): 1565–73. http://dx.doi.org/10.1200/go.20.00400.

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PURPOSE This study aims to assess the detection of cervical intraepithelial lesions grades 2 and 3 (CIN2-3) at 1 year after treatment with thermal ablation among human papillomavirus (HPV)–positive and visual inspection with acetic acid (VIA)–positive women. METHODS All women screened and triaged for cervical cancer at four government health facilities in Honduras who were eligible for ablative treatment were enrolled and treated with thermal ablation. Women with confirmed CIN2-3 and a subset of women with CIN1/normal diagnoses at baseline were evaluated at 12 months. Follow-up procedures incl

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Bruno, Maria Teresa, Nazario Cassaro, Francesca Bica, and Sara Boemi. "Progression of CIN1/LSIL HPV Persistent of the Cervix: Actual Progression or CIN3 Coexistence." Infectious Diseases in Obstetrics and Gynecology 2021 (March 9, 2021): 1–6. http://dx.doi.org/10.1155/2021/6627531.

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Objective. The natural history of the CIN1 lesions is characterized by an elevated rate of spontaneous regression (80%), some authors recognize a capacity to progress to HSIL in 10% of cases, and other authors do not recognize the capacity of progression of LSIL (CIN1). This study was aimed to evaluate the incidence of progression to HSIL (CIN3) in women with a histological diagnosis of LSIL (CIN1). Furthermore, to this end, we studied the histological outcomes of cone specimens collected by the LEEP. Methods. All the data were retrospectively analyzed. All participants underwent a follow-up o

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Ueda, Akihiko, Ken Yamaguchi, Sachiko Kitamura, et al. "Development of an artificial intelligence-based diagnostic system for the detection of abnormal colposcopic findings." JCO Global Oncology 9, Supplement_1 (2023): 82. http://dx.doi.org/10.1200/go.2023.9.supplement_1.82.

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82 Background: When performing colposcopic examinations in patients with abnormal cervical cytology, sufficient training is required to detect cervical intraepithelial neoplasia (CIN) with (1) high diagnostic accuracy and (2) minimizing time and reducing tissue biopsies. The aim of this study was to develop an artificial intelligence (AI)-based system that replicates expert colposcopic examination techniques to (1) identify CIN lesions with high accuracy and to (2) guide tissue sampling locations with high diagnostic performance, independent of examiner skill. Methods: A retrospective analysis

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Tian, Rui, Zifeng Cui, Dan He, et al. "Risk stratification of cervical lesions using capture sequencing and machine learning method based on HPV and human integrated genomic profiles." Carcinogenesis 40, no. 10 (2019): 1220–28. http://dx.doi.org/10.1093/carcin/bgz094.

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Abstract From initial human papillomavirus (HPV) infection and precursor stages, the development of cervical cancer takes decades. High-sensitivity HPV DNA testing is currently recommended as primary screening method for cervical cancer, whereas better triage methodologies are encouraged to provide accurate risk management for HPV-positive women. Given that virus-driven genomic variation accumulates during cervical carcinogenesis, we designed a 39 Mb custom capture panel targeting 17 HPV types and 522 mutant genes related to cervical cancer. Using capture-based next-generation sequencing, HPV

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del Pino, Marta, Adriana Sierra, Lorena Marimon, et al. "CADM1, MAL, and miR124 Promoter Methylation as Biomarkers of Transforming Cervical Intrapithelial Lesions." International Journal of Molecular Sciences 20, no. 9 (2019): 2262. http://dx.doi.org/10.3390/ijms20092262.

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Background: Squamous intraepithelial lesions/cervical intraepithelial neoplasias (SIL/CIN) are high-risk human papilloma virus (hrHPV)-related lesions which are considered as high grade (HSIL/CIN2-3) or low grade (LSIL/CIN1) lesions according to their risk of progression to cervical cancer (CC). Most HSIL/CIN2-3 are considered as transforming hrHPV infections, so truly CC precursors, although some clear spontaneously. hrHPV testing has a high sensitivity for the detection of HSIL/CIN2-3 but a relatively low specificity for identifying transforming lesions. We aimed to determine whether the com

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Cho, Bum-Joo, Jeong-Won Kim, Jungkap Park, et al. "Automated Diagnosis of Cervical Intraepithelial Neoplasia in Histology Images via Deep Learning." Diagnostics 12, no. 2 (2022): 548. http://dx.doi.org/10.3390/diagnostics12020548.

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Artificial intelligence has enabled the automated diagnosis of several cancer types. We aimed to develop and validate deep learning models that automatically classify cervical intraepithelial neoplasia (CIN) based on histological images. Microscopic images of CIN3, CIN2, CIN1, and non-neoplasm were obtained. The performances of two pre-trained convolutional neural network (CNN) models adopting DenseNet-161 and EfficientNet-B7 architectures were evaluated and compared with those of pathologists. The dataset comprised 1106 images from 588 patients; images of 10% of patients were included in the

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Kremer, Wieke, Marjolein van Zummeren, Daniëlle Heideman, et al. "HPV16-Related Cervical Cancers and Precancers Have Increased Levels of Host Cell DNA Methylation in Women Living with HIV." International Journal of Molecular Sciences 19, no. 11 (2018): 3297. http://dx.doi.org/10.3390/ijms19113297.

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Data on human papillomavirus (HPV) type-specific cervical cancer risk in women living with human immunodeficiency virus (WLHIV) are needed to understand HPV–HIV interaction and to inform prevention programs for this population. We assessed high-risk HPV type-specific prevalence in cervical samples from 463 WLHIV from South Africa with different underlying, histologically confirmed stages of cervical disease. Secondly, we investigated DNA hypermethylation of host cell genes ASCL1, LHX8, and ST6GALNAC5, as markers of advanced cervical disease, in relation to type-specific HPV infection. Overall,

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Popiel, Aneta, Aleksandra Piotrowska, Patrycja Sputa-Grzegrzolka, et al. "Preliminary Study on the Expression of Testin, p16 and Ki-67 in the Cervical Intraepithelial Neoplasia." Biomedicines 9, no. 8 (2021): 1010. http://dx.doi.org/10.3390/biomedicines9081010.

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Cervical cancer is one of the most common malignant cancers in women worldwide. The 5-year survival rate is 65%; nevertheless, it depends on race, age, and clinical stage. In the oncogenesis of cervical cancer, persistent HPV infection plays a pivotal role. It disrupts the expression of key proteins as Ki-67, p16, involved in regulating the cell cycle. This study aimed to identify the potential role of testin in the diagnosis of cervical precancerous lesions (CIN). The study was performed on selected archival paraffin-embedded specimens of CIN1 (31), CIN2 (75), and CIN3 (123). Moderate positiv

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Onuki, Mamiko, Kasumi Yamamoto, Hideaki Yahata, et al. "Changes in HPV16/18 Prevalence among Unvaccinated Women with Cervical Intraepithelial Neoplasia in Japan: Assessment of Herd Effects following the HPV Vaccination Program." Vaccines 10, no. 2 (2022): 188. http://dx.doi.org/10.3390/vaccines10020188.

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Since the human papillomavirus (HPV) vaccination program for Japanese girls aged 12–16 years began in 2010, vaccination uptake has been low in women born before 1993 but high (approximately 70%) in those born during 1994–1999. We previously compared the prevalence of vaccine types HPV16 and HPV18 in cervical intraepithelial neoplasia grade 1–3 (CIN1–3) or adenocarcinoma in situ (AIS) between vaccinated and unvaccinated cohorts and found direct protection effects among vaccinated women in Japan. In this study, we focused on changes in HPV16/18 prevalence among “unvaccinated” cohorts with CIN/AI

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Singh, Charanjeet, J. Carlos Manivel, Alexander M. Truskinovsky, et al. "Variability of Pathologists' Utilization of p16 and Ki-67 Immunostaining in the Diagnosis of Cervical Biopsies in Routine Pathology Practice and Its Impact on the Frequencies of Cervical Intraepithelial Neoplasia Diagnoses and Cytohistologic Correlations." Archives of Pathology & Laboratory Medicine 138, no. 1 (2014): 76–87. http://dx.doi.org/10.5858/arpa.2012-0472-oa.

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Context.—The use of p16 in cervical biopsies improves the accuracy of cervical intraepithelial neoplasia (CIN) diagnosis and grading and decreases its interpathologist variability. Objective.—To determine the impact of the frequency of use of p16 immunostains in cervical biopsies on pathologists' diagnoses of CIN grade 1 and grade 2 or above (CIN1 and CIN2+) and on cytohistologic correlations. Design.—We identified all cervical biopsy specimens with cytologic correlations subjected or not to p16 staining from January 1, 2005, to September 30, 2010; calculated each pathologist's percentage of p

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Panjkovic, Milan, and Tatjana Ivkovic-Kapicl. "Angiogenesis in squamous precancerous cervical lesions." Vojnosanitetski pregled 64, no. 1 (2007): 7–11. http://dx.doi.org/10.2298/vsp0701007p.

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Background/Aim. Vascularisation is one of basic tumor's characteristics. Neoangiogenesis starts at the stage of the dysplastic epithelial changes, thus before the progression into invasive lesion. This study was designed to determine the relation between stromal angiogenesis and the grade of cervical intraepithelial changes (CIN). Methods. The tissue sections of 50 cone biopsies were immunohistochemically stained for CD31 antigen, a marker for endothelial cells. All microvessels along the basement membrane subtending dysplastic epithelium were counted. The mean microvessel count was calculated

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Keegan, Niamh M., Andrea Arfe, Ethan Barnett, et al. "Chromosomal instability (CIN) in circulating tumor cells (CTC) predicts for taxane sensitivity in metastatic castration-resistant prostate cancer (mCRPC)." Journal of Clinical Oncology 40, no. 16_suppl (2022): 5026. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.5026.

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5026 Background: Few clinically validated biomarkers can inform therapy (tx) sequencing in mCRPC. Previously, we credentialed a biomarker of CIN in individual CTCs using phenotypic identification of cells with ≥9 large scale transitions (LSTs) and classification of CIN as high when detected in ≥3 CTC/mL (CIN3+). CIN3+ was associated with shorter radiographic progression survival (rPFS) and overall survival (OS) following taxane (T) or androgen receptor signaling inhibitor (ARSi) tx in mCRPC. Similarly, high CIN defined as ≥1 CTC/mL with ≥9 LSTs (CIN1+) predicts worse rPFS and OS following ARSi

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van Zummeren, Marjolein, Annemiek Leeman, Wieke W. Kremer, et al. "Three-tiered score for Ki-67 and p16ink4a improves accuracy and reproducibility of grading CIN lesions." Journal of Clinical Pathology 71, no. 11 (2018): 981–88. http://dx.doi.org/10.1136/jclinpath-2018-205271.

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AimsTo investigate the accuracy and reproducibility of a scoring system for cervical intraepithelial neoplasia (CIN1–3) based on immunohistochemical (IHC) biomarkers Ki-67 and p16ink4a.Methods115 cervical tissue specimens were reviewed by three expert gynaecopathologists and graded according to three strategies: (1) CIN grade based on H&E staining only; (2) immunoscore based on the cumulative score of Ki-67 and p16ink4a only (0–6); and (3) CIN grade based on H&E supported by non-objectified IHC 2 weeks after scoring 1 and 2. The majority consensus diagnosis of the CIN grade based on H&

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Doutre, Sylviane, Tanvier Omar, Olga Goumbri-Lompo, et al. "Cervical intraepithelial neoplasia (CIN) in African women living with HIV: role and effect of rigorous histopathological review by a panel of pathologists in the HARP study endpoint determination." Journal of Clinical Pathology 71, no. 1 (2017): 40–45. http://dx.doi.org/10.1136/jclinpath-2017-204512.

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AIMSTo analyse the effect of the expert end-point committee (EPC) review on histological endpoint classification of cervical intraepithelial neoplasia (CIN).MethodsA cohort of women living with HIV were recruited in Burkina Faso (BF) and South Africa (SA) and followed over 18 months. Four-quadrant cervical biopsies were obtained in women with abnormalities detected by at least one screening test. A central review by a panel of five pathologists was organised at baseline and at endline.ResultsAt baseline the prevalence of high-grade CIN (CIN2+) was 5.1% (28/554) in BF and 23.3% (134/574) in SA

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Stearns, T., M. A. Hoyt, and D. Botstein. "Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function." Genetics 124, no. 2 (1990): 251–62. http://dx.doi.org/10.1093/genetics/124.2.251.

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Abstract Three new genes affecting microtubule function in Saccharomyces cerevisiae were isolated by screening for mutants displaying supersensitivity to the antimicrotubule drug benomyl. Such mutants fall into six complementation groups: TUB1, TUB2 and TUB3, the three tubulin genes of yeast, and three new genes, which we have named CIN1, CIN2 and CIN4. Mutations in each of the CIN genes were also independently isolated by screening for mutants with increased rates of chromosome loss. Strains bearing mutations in the CIN genes are approximately tenfold more sensitive than wild type to both ben

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Okayama, Kaori, Hirokazu Kimura, Koji Teruya, et al. "Correlation between Human Papillomavirus Codetection Profiles and Cervical Intraepithelial Neoplasia in Japanese Women." Microorganisms 8, no. 12 (2020): 1863. http://dx.doi.org/10.3390/microorganisms8121863.

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Human papillomavirus (HPV) infection is thought to be strongly associated with the precarcinomatous state cervical intraepithelial neoplasia (CIN) and cervical carcinoma. To accurately assess the correlation between HPV detection profiles and CIN, the uniplex E6/E7 polymerase chain reaction (PCR) method was used. We detected HPV (37 genotypes) in 267 CIN cases. The detection of a single high-risk HPV genotype occurred in 69.7% of CIN1 and worse than CIN1 (CIN1+) cases whereas other types were detected in 11.6% of cases. Codetection of high-risk HPV genotypes occurred in 4.9% of CIN1+ cases. Th

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Li, Mingzhu, Chao Zhao, Yun Zhao, et al. "Association and Effectiveness of PAX1 Methylation and HPV Viral Load for the Detection of Cervical High-Grade Squamous Intraepithelial Lesion." Pathogens 12, no. 1 (2022): 63. http://dx.doi.org/10.3390/pathogens12010063.

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Background: PAX1 methylation (PAX1m) and HPV viral load (VL) have been reported to detect cervical high-grade squamous intraepithelial lesions (HSIL), but the relationship between them is unclear. This study aimed to evaluate the correlation between HPV VL and PAX1m and its effectiveness in predicting cervical lesions. (2) Methods: A total of 476 women referred to colposcopy for abnormal cervical screening at the Peking University People’s Hospital between November 2020 and November 2021 were enrolled. PAX1m and HPV VL were determined by QMSP and BMRT-HPV reports type-specific VL/10,000 cells,

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Wang, Wei, Aimin Yang, Yuanxing Li, et al. "Red blood cell folate, high-risk human papillomavirus risk and cervical intraepithelial neoplasia development: A large Chinese community-based cohort study of cervical screening." Journal of Clinical Oncology 39, no. 15_suppl (2021): 10547. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.10547.

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10547 Background: Although low folate status has been implicated in cervical carcinogenesis, large-scale population-based prospective cohort studies controlling for high-risk types of human papillomavirus (hrHPV) infection are lacking. The aim of this study is to evaluate the associations of red blood cell (RBC) folate, hrHPV infection risk and cervical intraepithelial neoplasia (CIN) development. Methods: In this prospective, population-based cohort study, we analyzed the cross-sectional data of 2304 women from a large cervical cancer screening program of 40,000 women aged 19-65 years in the

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Apter, Dan, Cosette M. Wheeler, Jorma Paavonen, et al. "Efficacy of Human Papillomavirus 16 and 18 (HPV-16/18) AS04-Adjuvanted Vaccine against Cervical Infection and Precancer in Young Women: Final Event-Driven Analysis of the Randomized, Double-Blind PATRICIA Trial." Clinical and Vaccine Immunology 22, no. 4 (2015): 361–73. http://dx.doi.org/10.1128/cvi.00591-14.

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ABSTRACTWe report final event-driven analysis data on the immunogenicity and efficacy of the human papillomavirus 16 and 18 ((HPV-16/18) AS04-adjuvanted vaccine in young women aged 15 to 25 years from the PApilloma TRIal against Cancer In young Adults (PATRICIA). The total vaccinated cohort (TVC) included all randomized participants who received at least one vaccine dose (vaccine,n= 9,319; control,n= 9,325) at months 0, 1, and/or 6. The TVC-naive (vaccine,n= 5,822; control,n= 5,819) had no evidence of high-risk HPV infection at baseline, approximating adolescent girls targeted by most HPV vacc

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Mazurec, Karolina, Martyna Trzeszcz, Maciej Mazurec, Christopher Kobierzycki, Robert Jach, and Agnieszka Halon. "Distribution of 14 High-Risk HPV Types and p16/Ki67 Dual-Stain Status in Post-Colposcopy Histology Results: Negative, Low- and High-Grade Cervical Squamous Intraepithelial Lesions." Cancers 16, no. 19 (2024): 3401. http://dx.doi.org/10.3390/cancers16193401.

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Background: Determining the distribution of high-risk human papillomavirus (HR-HPV) types in histologic low-(LSIL) and high-grade (HSIL/CIN2+) squamous intraepithelial lesions through a diagnostic process in a cervical cancer prevention provides one of the key etiological factors behind further progression and persistence. Incorporating novel high-grade cervical lesion biomarkers such as p16/Ki67 dual staining (DS) alongside HPV typing has become important in detecting cervical precancers. Methods: Among 28,525 screening tests and 602 histology results, 559 cases with HR-HPV and histology resu

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Kruse, Arnold‐Jan, Susanne Buhr‐Wildhagen, Emiel A. Janssen, and Jan P. A. Baak. "The Relationship between Syntactic Structure Analysis Features, Histological Grade and High-Risk HPV DNA in Cervical Intraepithelial Neoplasia." Analytical Cellular Pathology 26, no. 3 (2004): 135–41. http://dx.doi.org/10.1155/2004/592020.

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Aim: To assess the correlation between syntactic structure analysis (SSA) features, revised dysplasia grade and the presence of high‐risk human papillomavirus DNA in cervical intraepithelial neoplasia (CIN). Materials and methods: HPV polymerase chain reaction (PCR) was assessed in 101 consecutive biopsies and consensus in CIN grade between the experts occurred in 88 cases (CIN1=16, CIN2=27, CIN3=45). SSA was performed in the diagnostic histological section of the CIN lesions in these patients and SSA features were compared with the blind review CIN grade, and presence/absence of high‐risk HPV

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Zuo, Qiangqiang, Weinan Zheng, Jinli Zhang, et al. "Methylation in the Promoters of HS3ST2 and CCNA1 Genes is Associated with Cervical Cancer in Uygur Women in Xinjiang." International Journal of Biological Markers 29, no. 4 (2014): 354–62. http://dx.doi.org/10.5301/jbm.5000107.

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We assessed the suitability of HS3ST2 and CCNA1 genes as biomarkers for the early detection of cervical cancer in Uygur women in Xinjiang, China. Methylation-specific PCR (MSP) and HPV (HPV16 and HPV18)–specific PCR were performed on 110 cervical samples: 40 normal cervices, 10 cervical intraepithelial neoplasia 1 (CIN1), 10 CIN2, 10 CIN3 and 40 cervical cancer tissues. The expression of the 2 genes was measured by reverse transcription PCR (RT-PCR) in 10 methylation-positive and 10 methylation-negative cervical tissues. We found that both HS3ST2 and CCNA1 genes were methylated in 38 of the 40

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Popiel-Kopaczyk, Aneta, Aleksandra Piotrowska, Patrycja Sputa-Grzegrzolka, et al. "The Immunohistochemical Expression of Epithelial–Mesenchymal Transition Markers in Precancerous Lesions and Cervical Cancer." International Journal of Molecular Sciences 24, no. 9 (2023): 8063. http://dx.doi.org/10.3390/ijms24098063.

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In the epithelial–mesenchymal transition (EMT) process, cells lose their epithelial phenotype and gain mesenchymal features. This phenomenon was observed in the metastatic phase of neoplastic diseases, e.g., cervical cancer. There are specific markers that are expressed in the EMT. The aim of this study was to determine the localization of and associations between the immunohistochemical (IHC) expression of TWIST, SNAIL, and SLUG proteins in precancerous lesions and cervical cancer. The IHC analysis disclosed higher expressions of EMT markers in precancerous lesions and cervical cancer than in

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Ramírez, Martha Isabel González, Samuel Agudelo, Maria Cecilia Agudelo, et al. "Abstract 1497: miRNA expression analysis in high-risk HPV-positive cervical scrapes for the detection of cervical disease." Cancer Research 82, no. 12_Supplement (2022): 1497. http://dx.doi.org/10.1158/1538-7445.am2022-1497.

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Abstract Cervical cancer is the fourth most frequently diagnosed cancer and the fourth leading cause of cancer death in women, with an estimated 604,000 new cases and 342,000 deaths worldwide in 2020. Persistent infections with high-risk HPV (hrHPV) genotypes can lead to high-grade lesions (Cervical Intraepithelial Neoplasia Grade 2 or higher, CIN2+), that if left untreated progress to cancer. hrHPV test has high sensitivity to detect CIN2+, but it has low specificity because close to 90% of women spontaneously clear the infection. Biomarkers to stratify hrHPV+ women with cervical lesions that

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Cortecchia, Stefania, Giuseppe Galanti, Cecilia Sgadari, et al. "ATL." International Journal of Gynecologic Cancer 23, no. 9 (2013): 1663–69. http://dx.doi.org/10.1097/igc.0b013e3182a80b14.

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ObjectiveThe p16Ink4a (p16) tumor-suppressor protein is a biomarker for activated expression of human papillomavirus oncogenes. However, data are insufficient to determine whether p16 overexpression predicts the risk for progression of low-grade cervical intraepithelial neoplasia (CIN). This study was aimed at evaluating the risk for progression to CIN2 or worse during a 3-year follow-up of an unselected series of 739 patients with CIN1 biopsy specimens tested for p16 expression.MethodsPositivity of p16 was defined as a diffuse overexpression in the basal/parabasal cell layers. Selection biase

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Basiletti, Jorge Alejandro, Joan Valls, Tomás Poklépovich, et al. "Human papillomavirus genotyping using next generation sequencing (NGS) in cervical lesions: Genotypes by histologic grade and their relative proportion in multiple infections." PLOS ONE 17, no. 11 (2022): e0278117. http://dx.doi.org/10.1371/journal.pone.0278117.

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Sensitive and specific genotyping of human papillomaviruses (HPVs) is critical for the surveillance and monitoring of the vaccine effectiveness. Here, HPV genotypes were identified in 137 cervical samples with different histology (79 ≤CIN1 and 58 CIN3+) using Nested-PCR followed by Next-Generation sequencing (NGS) and relative proportions for each genotype in multiple infections were computed. All samples had been previously genotyped by PCR-Reverse Blotting Hybridization (PCR-RBH) thus allowing for a concordance analysis between both techniques. Multiple infections were present in 85% of ≤CIN

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Schettino, Maria Teresa, Eleonora Petra Preti, Valeria Vietri та ін. "The Role of β1 Integrin/CD29 as a Potential Prognostic Factor for the Risk of Progression to Cervical Carcinoma in HPV-Associated Lesions". Medicina 60, № 3 (2024): 364. http://dx.doi.org/10.3390/medicina60030364.

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Background and Objectives: Available evidence reports the overexpression of β1 integrin in dysplastic rather than normal cervical tissue. We aimed to evaluate the involvement of β1 (CD29) integrin in the progressive pathogenesis of cervical intraepithelial neoplasia (CIN). Materials and Methods: From January 2019 to December 2021, we prospectively enrolled women undergoing a colposcopy with a cervical biopsy for abnormal cervical cytology and/or undefined cytology with a positive HPV DNA test and women with relapsing cervical inflammatory disorders. Based on the histopathological results, wome

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Cuschieri, Kate, Daan Geraets, Jack Cuzick, et al. "Performance of a Cartridge-Based Assay for Detection of Clinically Significant Human Papillomavirus (HPV) Infection: Lessons from VALGENT (Validation of HPV Genotyping Tests)." Journal of Clinical Microbiology 54, no. 9 (2016): 2337–42. http://dx.doi.org/10.1128/jcm.00897-16.

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The Validation of Human Papillomavirus (HPV) Genotyping Tests (VALGENT) studies offer an opportunity to clinically validate HPV assays for use in primary screening for cervical cancer and also provide a framework for the comparison of analytical and type-specific performance. Through VALGENT, we assessed the performance of the cartridge-based Xpert HPV assay (Xpert HPV), which detects 14 high-risk (HR) types and resolves HPV16 and HPV18/45. Samples from women attending the United Kingdom cervical screening program enriched with cytologically abnormal samples were collated. All had been previou

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Klinyshkova, Tatiana V., Irina B. Samosudova, and Mariia S. Buyan. "Comparative evaluation of the results of an immunocytochemical study of P16/Ki-67 coexpression in patients with cervical intraepithelial neoplasia associated with human papillomavirus." Gynecology 23, no. 4 (2021): 341–45. http://dx.doi.org/10.26442/20795696.2021.4.200949.

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Aim. To evaluate the results of an immunocytochemical study of p16/Ki-67 double staining in the cervical epithelium of patients with cervical intraepithelial neoplasia (CIN) associated with high-risk human papillomavirus (HPVhr) in comparison with patients without cervical pathology. Materials and methods. The comparative study included the results of examination of 75 patients divided into 4 groups. Patients with CIN1 comprised the 1st main group (n=21), women with CIN2CIN3 the 2nd main group (n=26), the comparison group consisted of patients with latent HPV infection (n=15) and the con

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Yuan, Gao. "Correlation between ER, PR, P53, Ki67 expression, and high-risk HPV infection in patients with different levels of cervical intraepithelial neoplasia." European Journal of Inflammation 18 (January 2020): 205873922093308. http://dx.doi.org/10.1177/2058739220933084.

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This study was designed to investigate the correlation between high-risk human papillomavirus (HPV) infection and the expression of IHC markers (ER, PR, p53, Ki67) in patients with different grades of cervical intraepithelial neoplasia (CIN). It was a retrospective study, which was conducted from June 2016 to June 2018. 140 specimens of CIN were collected from the pathology department of a certain hospital that included 40 specimens of CIN1, 50 specimens of CIN2 and 50 specimens of CIN3. The expression of ER, PR, P53 and Ki67 were determined by immunohistochemistry. The high-risk HPV infection

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Wang, Wei, Aimin Yang, Huina Zhang, et al. "Associations of RBC and Serum Folate Concentrations with Cervical Intraepithelial Neoplasia and High-Risk Human Papillomavirus Genotypes in Female Chinese Adults." Journal of Nutrition 152, no. 2 (2021): 466–74. http://dx.doi.org/10.1093/jn/nxab396.

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ABSTRACT Background Although folate status is associated with cervical carcinogenesis, it is not clear whether folate deficiency is associated with risk of cervical intraepithelial neoplasia (CIN) progression and infection with high-risk human-papillomavirus (hrHPV). Objectives To evaluate the associations of RBC and serum folate concentrations with prevalence of CIN grades and hrHPV infection, their interactions with prevalence of CIN grades, and RBC folate with the risk of CIN1 progressing to CIN2. Methods Using data from the Shanxi CIN cohort of 2304 female Chinese adults, we used logistic-

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Brun, J. L., N. Nocart, V. Charbonneau, O. Delorme, M. Marty, and I. Garrigue. "O117 HPV DNA AND mRNA EXPRESSION IN CIN2 MIMICS CIN1 MORE THAN CIN3." International Journal of Gynecology & Obstetrics 119 (October 2012): S301. http://dx.doi.org/10.1016/s0020-7292(12)60547-5.

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