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Journal articles on the topic 'Cinitapride'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

&NA;. "Cinitapride." Reactions Weekly &NA;, no. 1312 (2010): 18. http://dx.doi.org/10.2165/00128415-201013120-00060.

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Roy, Shikha M. N., Santos H. M. Yetal, Sangita V. Chavan, Vara D. R. Pradhan, and Santosh S. Joshi. "Determination of Free Levels of Cinitipride in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry." E-Journal of Chemistry 5, no. 3 (2008): 453–60. http://dx.doi.org/10.1155/2008/242986.

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A rapid, sensitive and specific method to quantify cinitapride in human plasma using risperidone as the internal standard is described. Sample preparation involved simple solid phase extraction procedure. The extract was analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry API-4000 (LC-MS/MS). Chromatography was performed isocratically on Thermo Hypurity C18analytical column, (50 mm x 4.6 mm, 5µm i.d.). The assay of cinitapride was linear calibration curve over the range 20.118 pg mL−1to 2011.797 pg mL−1. Plasma concentrations of cinitapride were

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3

Roy, S. M. N., Kiran V. Mangaonkar, A. Y. Desai, and Santosh M. Yetal. "RP-HPLC Method for the Determination of Cinitapride in the Presence of its Degradation Products in Bulk Drug." E-Journal of Chemistry 7, no. 1 (2010): 311–19. http://dx.doi.org/10.1155/2010/259507.

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A reverse phase HPLC method is described for the determination of cinitapride hydrogen tartrate in the presence of its degradation products in bulk drug. A drug was subjected to all stress conditions such as reduction, oxidation acidic and alkaline medium. Chromatography was recorded on an Intersil ODS-3 column using mixture of acetonitrile and phosphate buffer, pH adjusted to 6.7 in the ratio (70:30 v/v) as the mobile phase at the rate of 1.0 mL/min with detection at 260 nm. Glimepride was used as internal standard. The retention time of drug cinitapride was 3.8 min and glimepride an internal

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4

Dighade, N. R., S. P. Padmane, and A. V. Kasture. "A VALIDATED RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PANTOPRAZOLE AND CINITAPRIDE IN A PHARMACEUTICAL FORMULATION." INDIAN DRUGS 51, no. 01 (2014): 27–33. http://dx.doi.org/10.53879/id.51.01.p0027.

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The study describes a validated stability indicating reverse- phase HPLC method for the simultaneous estimation of pantoprazole and cinitapride in capsule formulation. The proposed RP-HPLC method utilizes an Eclipse XDB C18 Column (150 × 4.6 mm i.d., 5μm), optimum mobile phase consisting of 10 mM phosphate buffer: acetonitrile: THF in the ratio of 64:36:0.5 V/V (pH 3.5) V/V, effluent flow rate 1 mL/min and UV detection wavelength of 266 nm. The selected chromatographic conditions were found to effectively separate pantoprazole and cinitapride with retention time of 7.17 min and 3.56 min, respe

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Humaira, Syeda, Akalanka Dey, S. Appala Raju, and Syed Sanaullah. "Development and Validation of a Rapid RP HPLC Method for the Determination of Cinitapride Hydrogen Tartarate in Solid Oral Dosage Forms." E-Journal of Chemistry 8, no. 3 (2011): 1424–29. http://dx.doi.org/10.1155/2011/614160.

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In the present study a simple, sensitive rapid and accurate HPLC method with UV detection for the analysis of cinitapride hydrogen tartarate was developed and validated in solid dosage forms. The method utilized gradient elution technique with C18 column (150×4.6 mm I.D, 5 μm particle size) with mobile phase consisting of 0.1% formic acid in water and acetonitrile The detection wavelength was at 268 nm, with flow rate of 0.5 mL/min and injection volume of 10 μL for separation of cinitapride in bulk drugs and pharmaceutical formulations. The gradient elution was developed for better and optimiz

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6

González Martı́n, I., C. González Pérez, and M. A. Blanco López. "Polarographic determination of cisapride and cinitapride." Analytica Chimica Acta 368, no. 1-2 (1998): 175–81. http://dx.doi.org/10.1016/s0003-2670(98)00055-5.

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7

Thangabalan, Boovizhikannan, Getu Kahsay, and Tadele Eticha. "Development and Validation of a High-Performance Liquid Chromatographic Method for the Determination of Cinitapride in Human Plasma." Journal of Analytical Methods in Chemistry 2018 (August 28, 2018): 1–5. http://dx.doi.org/10.1155/2018/8280762.

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A precise and reliable reversed-phase high-performance liquid chromatographic method with ultraviolet detection was developed and validated to determine cinitapride in human plasma. After liquid-liquid extraction, chromatographic separation was achieved on a Nucleosil C18 (25 cm × 4.6 mm, 5 µm) column with an isocratic elution consisting of 10 mM ammonium acetate (pH 5.2), methanol, and acetonitrile, 40 : 50 : 10, v/v/v. The developed method was validated as per US FDA guidelines for its linearity, selectivity, sensitivity, precision, accuracy, and stability. Satisfactory findings were obtaine

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Rijhwani, Puneet, Agarwal C M, Mohammed Shoaib, Prerna Upadhyaya, and Pradeep Agarwal. "EFFICACY OF CINITAPRIDE HYDROGEN TARTARATE IN GERD." Journal of Evidence Based Medicine and Healthcare 1, no. 8 (2014): 1073–79. http://dx.doi.org/10.18410/jebmh/2014/157.

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9

Fernandez, A. G., and D. J. Roberts. "Cinitapride Hydrogen Tartrate < Rec INNM >." Drugs of the Future 16, no. 10 (1991): 885. http://dx.doi.org/10.1358/dof.1991.016.10.151174.

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10

Slíva, Jiří. "Cinitaprid expands treatment options for functional dyspepsia." Gastroenterologie a hepatologie 78, no. 5 (2024): 441–43. http://dx.doi.org/10.48095/ccgh2024441.

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reatment of functional dyspepsia is often medically difficult and requires a comprehensive approach, including the drug group prokinetics. In the Czech Republic, it is now being expanded to include the active substance cinitapride. The presented text summarizes its basic pharmacological properties and summarizes the available relevant aspects of its clinical use.

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11

Mathew, Mercy, Ravikumar, Simila Madathil, Anju Govind, and VB Narayana Swamy. "Formulation and Evaluation of Cinitapride Controlled Release Tablets." Asian Journal of Pharmaceutical Research 6, no. 2 (2016): 87. http://dx.doi.org/10.5958/2231-5691.2016.00015.0.

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12

de Souza, Aaron, and RainhaJ de Souza. "Parkinsonism and tremor complicating long-term cinitapride use." Annals of Indian Academy of Neurology 20, no. 4 (2017): 435. http://dx.doi.org/10.4103/aian.aian_225_17.

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13

Alarcón de la Lastra, C., C. La Casa, M. J. Martin, and V. Motilva. "Effects of cinitapride on gastric ulceration and secretion in rats." Inflammation Research 47, no. 3 (1998): 131–36. http://dx.doi.org/10.1007/s000110050301.

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14

D., Sri Vidya G. Chandra Sekhar* V. Prabhakara Rao K. Aruna. "DIFFERENTIAL PULSE VOLTAMMETRIC DETERMINATION OF CINITAPRIDE USING CARBON PASTE ELECTRODE." INTERNATIONAL JOURNAL OF ENGINEERING SCIENCES & RESEARCH TECHNOLOGY 6, no. 8 (2017): 220–25. https://doi.org/10.5281/zenodo.839192.

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The voltammetric performance of cinitapride (CNTP) was investigated at carbon paste electrode using differential pulse voltammetry and cyclic voltammetry. The drug under study exhibited a single, well-defined reduction peak owing to the reduction of NO<sub>2</sub>. The electrode and reaction conditions which yielded maximum peak current were established using differential pulse voltammetry. A linear relationship was observed between the peak current and the concentration of CNTP over the range 2.35x10<sup>-6</sup> M to 4.25x10<sup>-4</sup>M. The limits of detection and limits of quantitation w

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15

Chinnala, Krishna Mohan, and Sirish Vodithala. "FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISINTEGRATING TABLETS OF CINITAPRIDE HYDROGEN TARTARATE BY USING DIRECT COMPRESSION TECHNIQUE." International Journal of Current Pharmaceutical Research 9, no. 6 (2017): 98. http://dx.doi.org/10.22159/ijcpr.2017v9i6.23659.

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Objective: In the present study, efforts were taken to develop fast disintegrating tablets of Cinitapride hydrogen tartrate, is a gastro-prokinetic agent and antiulcer agent with an objective to achieve rapid disintegration, and further improving the bioavailability of the drug. Also, to resolve the swallowing problems (Dysphasia) in pediatric, geriatric patients by rapid disintegration in saliva and improve the patient compliance.Methods: Fast disintegrating tablets were prepared by direct compression method using superdisintegrants like crospovidone (CP), croscarmellose sodium (CCS), sodium

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16

Thangabalan, B., A. Elphine Prabahar, R. Kalaichelvi, and P. Vijayaraj Kumar. "UV Spectrophotometric Method for Determination of Cinitapride in Pure and its Solid Dosage Form." E-Journal of Chemistry 6, s1 (2009): S21—S24. http://dx.doi.org/10.1155/2009/856537.

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A new, rapid, precise, accurate and sensitive analytical method was developed for the UV spectrophotometric assay of cinitapride (CTP). The drug obeyed the Beer's law and showed good correlation. It showed absorption maxima at 260 nm in methanol. The linearity was observed between 5-40 µg mL-1. The results of analysis were validated by recovery studies. The recovery was more than 99%. The proposed method is the only method available for spectrophotometric determination of the drug. It is simple, precise, sensitive and reproducible and can be used for the routine quality control testing of the

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17

Satyanarayana, K. V. V., and Rao Nageswara. "Validated spectophotometric methods for the assay of cinitapride hydrogen tartrate in pharmaceuticals." Chemical Industry and Chemical Engineering Quarterly 19, no. 2 (2013): 303–11. http://dx.doi.org/10.2298/ciceq120109065s.

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Three simple, selective and rapid spectrophotometric methods have been established for the determination of cinitapride hydrogen tartrate (CHT) in pharmaceutical tablets. The proposed methods are based on the diazotization of CHT with sodium nitrite and hydrochloric acid, followed by coupling with resorcinol, 1-benzoylacetone and 8-hydroxyquinoline in alkaline medium for methods A, B and C respectively. The formed azo dyes are measured at 442, 465 and 552 nm for methods A, B and C respectively. The parameters that affect the reaction were carefully optimized. Under optimum conditions, Beer?s l

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18

Motilva, V., A. López, C. Alarcón de la Lastra, M. J. Martin, and M. C. La Casa. "Effects of cinitapride in ethanol induced ulcer: Role of neutrophils and endogenous prostaglandins." Pharmacological Research 31 (January 1995): 96. http://dx.doi.org/10.1016/1043-6618(95)86645-0.

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19

Colado, M. I., M. J. Alfaro, V. L. del Val, and M. I. Martín. "Effect of cinitapride in isolated ileum obtained from guinea-pigs treated with morphine." General Pharmacology: The Vascular System 22, no. 5 (1991): 863–66. http://dx.doi.org/10.1016/0306-3623(91)90220-z.

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20

Kumari, Shruti, and Mukthinuthalapati Mathrusri Annapurna. "New Spectrophotometric Methods for the Assay of Cinitapride Hydrogen Tartrate (A Gastroprokinetic Drug)." Acta Scientific Pharmaceutical Sciences 7, no. 5 (2023): 33–38. http://dx.doi.org/10.31080/asps.2023.07.0951.

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21

Chiner, Eusebi, José Norberto Sancho-Chust, Mónica Llombart, et al. "Sleep-Related Painful Erection in a 50-Year-Old Man Successfully Treated with Cinitapride." Journal of Sexual Medicine 7, no. 11 (2010): 3789–92. http://dx.doi.org/10.1111/j.1743-6109.2010.01939.x.

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22

Puig, J., A. G. Fernández, P. Berga, and R. W. Gristwood. "Effects of cinitapride in the isolated rat esophagus and dog L.E.S. pressure in vivo." Gastroenterology 99, no. 4 (1990): 1211. http://dx.doi.org/10.1016/0016-5085(90)90705-6.

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23

Marquez, Helena, Joan Albertí, Miquel Salvà, Javier Saurina, and Sonia Sentellas. "Development of a UHPLC method for the assessment of the metabolic profile of cinitapride." Journal of Separation Science 34, no. 24 (2011): 3502–8. http://dx.doi.org/10.1002/jssc.201100073.

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24

MASSINGHAM, R., J. BOU, and D. J. ROBERTS. "A COMPARISON OF THE STIMULATORY EFFECTS OF METOCLOPRAMIDE AND CINITAPRIDE IN THE GUINEA-PIG ISOLATED ILEUM." Journal of Autonomic Pharmacology 5, no. 1 (1985): 41–53. http://dx.doi.org/10.1111/j.1474-8673.1985.tb00564.x.

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25

Hrdlička, Luděk. "Gapulsid® (cinitapride) – the unique prokinetic indicated for the treatment of upper functional dyspepsia and gastroesophageal reflux disease." Gastroenterologie a hepatologie 78, no. 4 (2024): 343–44. http://dx.doi.org/10.48095/ccgh2024343.

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26

Robert, Marta, Miquel Salvà, Rosa Segarra, et al. "The Prokinetic Cinitapride Has No Clinically Relevant Pharmacokinetic Interaction and Effect on QT during Coadministration with Ketoconazole." Drug Metabolism and Disposition 35, no. 7 (2007): 1149–56. http://dx.doi.org/10.1124/dmd.106.010835.

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27

Zhang, Xiong, Ying Wang, Junlin Cheng, et al. "Pharmacokinetics and tolerability of cinitapride in healthy Chinese volunteers: a randomized, open-label, single- and multiple-dose study." Xenobiotica 49, no. 3 (2018): 313–21. http://dx.doi.org/10.1080/00498254.2018.1447710.

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28

Du, Yiqi, Tun Su, Xinmiao Song, et al. "Efficacy and Safety of Cinitapride in the Treatment of Mild to Moderate Postprandial Distress Syndrome–predominant Functional Dyspepsia." Journal of Clinical Gastroenterology 48, no. 4 (2014): 328–35. http://dx.doi.org/10.1097/mcg.0000000000000033.

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29

Romero, Alarcón-de-la-Lastra, A. López, M. J. Martín, C. la Casa, and V. Motilva. "Cinitapride Protects against Ethanol-lnduced Gastric Mucosal Injury in Rats: Role of 5-Hydroxytryptamine, Prostaglandins and Sulf hydryl Compounds." Pharmacology 54, no. 4 (1997): 193–202. http://dx.doi.org/10.1159/000139487.

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30

VIDYADHARA, SURYADEVARA, YARRAGUNTLA SRINIVASA RAO, ANNE RAMU, REDDYVALAM LANKAPALLI SASIDHAR, and ANNE JAYA RAMYA. "Method Development and Validation for the Simultaneous Estimation of Cinitapride and Pantoprazole in Solid Dosage Forms By RP-HPLC." Oriental Journal Of Chemistry 29, no. 03 (2013): 1213–20. http://dx.doi.org/10.13005/ojc/290355.

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31

Marcelín-Jiménez, Gabriel, Leticia Contreras, Javier Esquivel, et al. "Development of an UPLC–MS/MS micromethod for quantitation of cinitapride in plasma and its application in a pharmacokinetic interaction trial." Bioanalysis 9, no. 6 (2017): 569–79. http://dx.doi.org/10.4155/bio-2016-0210.

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32

Santosh, Karajgi, Potadar Shripad, Gaviraj E.N, Patil Sudha, Shahapur Ajay, and Bhandarakavathe Maharani. "Development of a Validated Method for the Oral Dosage and Bulk Quantification of Pantoprazole and Cinitapride using RP-HPLC and Spectrophotometry." International Journal of Zoological Investigations 10, no. 2 (2024): 755–62. http://dx.doi.org/10.33745/ijzi.2024.v10i02.073.

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33

Martín, M., and M. D. C. Molina Liétor. "Quetiapine induced ischemic colitis: about two cases." European Psychiatry 65, S1 (2022): S726. http://dx.doi.org/10.1192/j.eurpsy.2022.1874.

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Introduction Due to its anticholinergic action, antipsychotic drugs, especially phenothiazines and atypical antipsychotics, have been described as a rare cause of drug-induced ischemic colitis. We present two cases of patients that were admitted to the gastroenterology unit of a general hospital and were diagnosed of quetiapine-induced ischemic colitis. Objectives To describe an uncommon side effect of neuroleptic treatment. Methods Case report and literature review. Results First patient, aged 73, with history of dysthymia, in treatment with desvenlafaxine, quetiapine, ketazolam, lorazepam, e

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34

Marquez, Helena, Joan Albertí, Miquel Salvà, Javier Saurina, and Sonia Sentellas. "Characterization of in vitro metabolic profiles of cinitapride obtained with liver microsomes of humans and various mammal species using UHPLC and chemometric methods for data analysis." Analytical and Bioanalytical Chemistry 403, no. 4 (2012): 909–16. http://dx.doi.org/10.1007/s00216-012-5795-z.

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35

Mearín, Fermín, María Josep Plazas, Marta Mas, and Joan Heras. "Seguridad cardiaca de cinitaprida." Gastroenterología y Hepatología 33, no. 8 (2010): 614. http://dx.doi.org/10.1016/j.gastrohep.2010.07.004.

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36

Castro, Francisco José, José Saavedra, Francisco López, Soledad Herrera, and Ernest Bragulat. "Intoxicación aguda por cinitaprida." Gastroenterología y Hepatología 34, no. 9 (2011): 662–63. http://dx.doi.org/10.1016/j.gastrohep.2011.04.008.

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37

Chaudhary, Hira, Eric Zeidman, Nahid Punjani, and Yasemin Tashman. "0971 Case Report: Sleep-Related Painful Erections Treated with Sodium Oxybate." SLEEP 46, Supplement_1 (2023): A429. http://dx.doi.org/10.1093/sleep/zsad077.0971.

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Abstract Introduction Sleep-related painful erection (SRPE) is a rare parasomnia characterized by painful penile erections during rapid eye movement sleep. Normal, painless erections continue to occur while awake. Approximately thirty cases have been reported in the literature. Multiple theories about potential pathophysiology have been proposed including neurologic dysfunction of the ischiocavernosus and bulbocavernosus, correlation with obstructive sleep apnea, and/or autonomic dysfunction. There is no known single effective treatment to date resulting in durable response despite multiple at

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38

Blazquez, I., A. Guillen-Del-Castillo, J. Corada, et al. "AB0832 CHRONIC INTESTINAL PSEUDO-OBSTRUCTION IN PATIENTS WITH SYSTEMIC SCLEROSIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1629.2–1629. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5168.

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BackgroundChronic intestinal pseudo-obstruction (CIPO) is one of the gastrointestinal manifestations related to systemic sclerosis (SSc). Despite its low incidence (5%), it burdens a high morbimortality.ObjectivesThe objective of the present study was to analyse a selected cohort of patients with SSc and CIPO and to describe the treatments they received, the response to them and the clinical outcome.MethodsSSc patients diagnosed with CIPO were selected for the study. There was analysed the baseline clinical variables, the period between the diagnosis of SSc and CIPO, the received therapies, an

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39

Portincasa, Piero, Fermin Mearin, Marta Robert, M. Josep Plazas, Marta Mas, and Joan Heras. "Eficacia y tolerabilidad de cinitaprida en el tratamiento de los pacientes con dispepsia funcional y vaciamiento gástrico enlentecido." Gastroenterología y Hepatología 32, no. 10 (2009): 669–76. http://dx.doi.org/10.1016/j.gastrohep.2009.06.013.

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40

"Cinitapride." Reactions Weekly 1681, no. 1 (2017): 104. http://dx.doi.org/10.1007/s40278-017-39380-x.

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41

"Cinitapride." Reactions Weekly 1621, no. 1 (2016): 71. http://dx.doi.org/10.1007/s40278-016-21624-4.

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42

A, Gaur, and Yashwant . "Development and Validation of UV Spectroscopic Method for Simultaneous Estimation of Pantoprazole and Cinitapride in Bulk and in Capsule Dosage FormC." International Journal of Pharmaceutical Quality Assurance 9, no. 4 (2018). http://dx.doi.org/10.25258/ijpqa.v9i4.14535.

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A new, rapid, precise, selective and sensitive Vierodt��s/simultaneous equation method is developed for the simultaneous estimation of pantoprazole (PNT) and cinitapride (CNT) in combined dosage form. In the developed method, absorbance was measured at 289 nm (�� max of Pantoprazole) and 267.2 nm (�� max of Cinitapride). The drugs obeyed the Beer��s law in the concentration range of 13-65��g/ml and 1-5 ��g/ml respectively for pantoprazole and cinitapride. Accuracy of the method was determined by recovery studies and was found to be 101.32 % and 98.9 % for Pantoprazole and Cinitapride respect

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Qi, Qingqing, Nana Wang, Han Liu, and Yanqing Li. "Prokinetics for the treatment of functional dyspepsia: an updated systematic review and network meta-analysis." BMC Gastroenterology 23, no. 1 (2023). http://dx.doi.org/10.1186/s12876-023-03014-9.

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Abstract Background Since the previous network meta-analysis assessing the efficacy of prokinetics for functional dyspepsia (FD), there have been a number of new studies and cinitapride is a new prokinetic agent for FD. This updated meta-analysis aimed to explore the efficacy and safety of prokinetics for FD. Methods An updated study search in Pubmed, EMBASE, Cochrane Library and Web of Science was conducted in literatures published from July 2015 to March 2023. Randomized controlled trials investigating the use of prokinetics in adult FD patients were included. The primary outcome was the tot

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44

Yan, Bing, Shimin Wang, Jian Chen, et al. "Evaluation of cinitapride's efficacy and safety in treating functional dyspepsia with overlapping symptoms: a real-world study in Chinese healthcare settings." Revista da Associação Médica Brasileira 71, no. 3 (2025). https://doi.org/10.1590/1806-9282.20241628.

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SUMMARY OBJECTIVE: Cinitapride, a gastrointestinal prokinetic, is commonly used for treating functional dyspepsia. However, large-scale, real-world data on its efficacy, especially in patients with overlapping symptoms, are limited. The aim of this study was to evaluate the clinical effectiveness and safety of cinitapride in Chinese patients with functional dyspepsia, including those with overlapping symptoms, in a real-world setting. METHODS: In this single-arm, prospective, multicentric study, 1,012 Chinese outpatients with functional dyspepsia and functional dyspepsia overlapping with gastr

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45

Srinivasulu, Gudipati, Kudavalli Jaya Satyanarayana, Padi Pratap Reddy, Pragathi Hegde, and Ranjan Chakrabarti. "Synthesis, Characterization and Biological Activity of Triazole Derivatives of Cinitapride." ChemInform 38, no. 3 (2007). http://dx.doi.org/10.1002/chin.200703127.

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46

Srinivasulu, G., Ρ. Pratap Reddy, Pragathi Hegde, and Ranjan Chakrabart. "SYNTHESIS AND BIOLOGICAL EVALUATION OF CINITAPRIDE RELATED DERIVATIVES AS POTENTIAL PROKINETIC AGENTS." Heterocyclic Communications 11, no. 1 (2005). http://dx.doi.org/10.1515/hc.2005.11.1.23.

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47

Suros, A., F. Adell, V. De Novoa, et al. "Cinitaprida en el tratamiento del reflujo gastroesofágico." Revista de Medicina de la Universidad de Navarra, February 21, 2017, 18–23. http://dx.doi.org/10.15581/021.8152.

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Con objeto de evaluar la eficacia y tolerancia de cinitaprida, 239 pacientes con reflujo gastroesofágico (RGE) fueron incluidos de forma randomizada en un estudio doble ciego paralelo para recibir tratamiento con cinitaprida, metoclopramida o placebo.  Cinitaprida fue significativamente más eficaz que metoclopramida para curar o mejorar los vómitos de los pacientes con RGE a los 14 días de tratamiento (P= 0.031) y para curar o mejorar la pesadez postprandial, pirosis, náuseas, regurgitación, dolor retroesternal y dolor epigástrico en estos pacientes, con resultados tendentes a la s

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48

"Cinitapride, a 5-HT4 receptor agonist, reverses stress- and cisplatin-induced gastroparesia in rats." Gastroenterology 108, no. 4 (1995): A672. http://dx.doi.org/10.1016/0016-5085(95)26999-1.

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49

Karanjia, Jasmine. "DEVELOPMENT AND VALIDATION OF CHEMOMETRIC ASSISTED SPECTROPHOTOMETRIC TECHNIQUE FOR SIMULTANEOUS ESTIMATION OF CINITAPRIDE AND PANTOPRAZOLE FROM BULK AND COMBINED DOSAGE FORM." International Journal of Pharmaceutical Sciences and Drug Research, March 1, 2015, 198–204. https://doi.org/10.25004/ijpsdr.2015.070213.

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This paper describes two sensitive, accurate and precise chemometric spectrophotometric methods for the simultaneous determination of Cinitapride hydrogen tartarate (CNT) and Pantoprazole sodium (PANTO) in bulk powder and capsules without prior separation. Multivariate calibration chemometric methods are proposed for simultaneous determination of CNT and PANTO. The chemometric methods applied are Principal Component Regression (PCR) and Partial Least Squares (PLS). These approaches are successfully applied to quantify both drugs using the information included in the absorption spectra of appro

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Campodónico, Diana María, Pablo Zubiaur, Paula Soria‐Chacartegui, et al. "CYP2C8 *3 and *4 define CYP2C8 phenotype: An approach with the substrate cinitapride." Clinical and Translational Science, September 6, 2022. http://dx.doi.org/10.1111/cts.13386.

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