Relevant bibliographies by topics / Cinnamic acid derivatives

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Cinnamic acid derivatives'

Author: Grafiati
Published: 4 June 2021
Last updated: 27 July 2025

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Journal articles on the topic "Cinnamic acid derivatives"

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Ruwizhi, Ngonidzashe, and Blessing Atim Aderibigbe. "Cinnamic Acid Derivatives and Their Biological Efficacy." International Journal of Molecular Sciences 21, no. 16 (2020): 5712. http://dx.doi.org/10.3390/ijms21165712.

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The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes and neurological disorders, among many, has been reported. Cinnamic acid is obtained from cinnamon bark. Its structure is composed of a benzene ring, an alkene double bond and an acrylic acid functional group making it possible to modify the aforementioned functionalities with a variety of compounds resulting in bioactive agents with enhanced efficacy. The nature of the substituents incorporated into cinnamic acid has been found to play a huge role in either enhancing or decreasing the biological ef
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Prakash, N. S., Devendra Reddy, R. Sundaram, et al. "Identification and quantification of cinnamic acid derivatives in Cichorium intybus seed and its extract by High- Performance Liquid Chromatography with Diode-Array Detector (HPLC-DAD) and Electrospray Ionization Mass Spectrophotometry (LC-MS/MS)." Universities' Journal of Phytochemistry and Ayurvedic Heights I, no. 34 (2023): 1–16. http://dx.doi.org/10.51129/ujpah-2022-34-1(1).

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A sensitive method coupling high-performance liquid chromatography (HPLC) with diode –array detector (DAD) and electrospray ionization mass spectrometry (MS) was optimized for separation, identification, and quantification of cinnamic acid derivatives in Cichorium intybus seed and its extract. Cinnamic acid derivatives such as chlorogenic acid, caffeic acid and Chicoric acid were quantified using respective standards. Apart from 4-o-Caffeoylqunic acid, other cinnamic acid derivative such as 3-o-caffeoylquinic acid was also identified and quantified by UV and MS/MS spectra and calculated as tot
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Wery, Guillaume, Karol Pastucha, Koen Robeyns, and Tom Leyssens. "The Inability of Metal Coordination to Control the Regioselectivity of Dimerization of Trans-Cinnamic Acid Derivatives." Crystals 14, no. 6 (2024): 530. http://dx.doi.org/10.3390/cryst14060530.

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Upon exposure to irradiation, trans-cinnamic acid can dimerize, producing truxinic and truxillic acids, regioisomers distinguished by the relative arrangement of acid and phenyl groups on the formed cyclobutane ring. Solid-state dimerization, governed by Schmidt’s specified conditions, hinges on the initial molecular setup. This study endeavors to manipulate the reaction’s outcome in the solid state. To achieve this, the target molecule was paired with metals (Ag, Cu) to modify molecular orientation in the solid. Investigated derivatives included para-hydroxy-trans-cinnamic acid, ortho-methoxy
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Ernawati, Teni, Maksum Radji, Muhammad Hanafi, Abdul Mun’im та Arry Yanuar. "Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents". Indonesian Journal of Chemistry 17, № 1 (2017): 151. http://dx.doi.org/10.22146/ijc.23572.

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This paper reviews biological activity of some cinnamic acid derivative compounds which are isolated from natural materials and synthesized from the chemical compounds as an agent of α-glucosidase inhibitors for the antidiabetic drug. Aegeline, anhydroaegeline and aeglinoside B are natural products isolated compounds that have potential as an α-glucosidase inhibitor. Meanwhile, α-glucosidase inhibitor class of derivatives of cinnamic acid synthesized compounds are p-methoxy cinnamic acid and p-methoxyethyl cinnamate. Chemically, cinnamic acid has three main functional groups: first is the subs
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Hasegawa, Toshio, Momohiro Hashimoto, Takashi Fujihara, and Hideo Yamada. "Aroma Profile of Galangal Composed of Cinnamic Acid Derivatives and Their Structure-Odor Relationships." Natural Product Communications 11, no. 10 (2016): 1934578X1601101. http://dx.doi.org/10.1177/1934578x1601101012.

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Cinnamic acid derivatives are important odorants due to their characteristic scent. Some fragrance materials, such as cinnamon bark, matsutake mushrooms, and Kaempferia galanga L. rhizome (galangal), contain several cinnamic acid derivatives as important odor constituents. The main odor constituent of galangal is ( E)-ethyl 4-methoxycinnamate, but the odor of this compound is different from that of galangal. We investigated the aroma profile of galangal using our previously described method that considers the intermolecular interactions of the odorant compounds with their receptors. Odorant co
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Peperidou, Aikaterini, Eleni Pontiki, Dimitra Hadjipavlou-Litina, Efstathia Voulgari, and Konstantinos Avgoustakis. "Multifunctional Cinnamic Acid Derivatives." Molecules 22, no. 8 (2017): 1247. http://dx.doi.org/10.3390/molecules22081247.

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Kabat, Małgorzata, Justyna Popiół, and Agnieszka Gunia-Krzyżak. "Cinnamic Acid Derivatives as Potential Multifunctional Agents in Cosmetic Formulations Used for Supporting the Treatment of Selected Dermatoses." Molecules 29, no. 23 (2024): 5806. https://doi.org/10.3390/molecules29235806.

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Cinnamic acid and its natural derivatives were primarily used in cosmetics as fragrance materials as well as skin and hair conditioners. Nowadays, not only natural but also synthetic cinnamic acid derivatives are used as active ingredients of cosmetic formulations. They still serve as fragrance ingredients but also as active ingredients supporting the treatment of selected dermatoses such as acne vulgaris, atopic dermatitis, and hyperpigmentation. They are also commonly used in anti-aging cosmetic formulations. On the other hand, several cinnamic acid derivatives used as fragrances in cosmetic
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Jacob, B. B., H. Baba, and J. O. Oluwadiya. "Synthesis, Characterization and evaluation of Anti-inflammatory and Antimicrobial Properties of some Cinnamic Acid Derivatives." Nigerian Journal of Pharmaceutical Research 16, no. 1 (2020): 1–8. http://dx.doi.org/10.4314/njpr.v16i1.1.

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Background: Cinnamic acid and derivatives are widely spread in plants. They are important intermediates in the synthesis of many aromatic compounds and are known to have diverse biological activities.Objectives: To synthesize, characterize and evaluate some cinnamic acid derivatives, for possible antimicrobial and anti-inflammatory activities.Material and methods: Different cinnamic acid derivatives were synthesized by Knoevenagel condensation reaction between malonic acid and various derivatives of benzaldehydes in the presence of pyridine and hydrochloric acid. The cinnamic acid epoxide was
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Hoai, N. T., Tran Thi Yen Ngoc, Nguyen Dang Nam та ін. "Effect oF β-Alanine on The Preparation of 4-Ethoxy-Cinnamic Acid". Open Materials Science Journal 12, № 1 (2018): 58–67. http://dx.doi.org/10.2174/1874088x01812010058.

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Objective:Cinnamic acid and its derivatives have a numerous potential applications in many different fields such as pharmacy, organic “building blocks”, and corrosion inhibitors.Method:It is well-known that Verley-Doebner modification is a high efficient method for the preparation of cinnamic acid derivaties, especially with the compounds containing electron-donating subtituents at para position in aromatic ring. In this paper, 4-ethoxy-cinnamic acid was synthesized according to Verley-Doebner reaction with the use of pyrine acting as catalyst and solvent. The effect of the β-alanine concentra
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Moreno-Robles, Antonio, Antonio Cala Peralta, Jesús G. Zorrilla, et al. "Structure−Activity Relationship (SAR) Study of trans-Cinnamic Acid and Derivatives on the Parasitic Weed Cuscuta campestris." Plants 12, no. 4 (2023): 697. http://dx.doi.org/10.3390/plants12040697.

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Cuscuta campestris Yunck. is a parasitic weed responsible for severe yield losses in crops worldwide. The selective control of this weed is scarce due to the difficult application of methods that kill the parasite without negatively affecting the infected crop. trans-Cinnamic acid is secreted by plant roots naturally into the rhizosphere, playing allelopathic roles in plant–plant communities, although its activity in C. campestris has never been investigated. In the search for natural molecules with phytotoxic activity against parasitic weeds, this work hypothesized that trans-cinnamic acid co
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Dissertations / Theses on the topic "Cinnamic acid derivatives"

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McNichols, Brett William. "Synthesis and Application of Styryl Phosphonic and Cinnamic Acid Derivatives." Thesis, Colorado School of Mines, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10624231.

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<p> Styryl phosphonic and cinnamic acid derivatives have been gaining attention as key candidates to modulate specific electrode properties in organic electronic devices such as work function, surface energies, wettability, and electron charge transfer kinetics that lead to increased efficiency, operational range, and device lifetimes. Very few of these acids are commercially available. The driving factor behind this research is to explore simple, high yield, and inexpensive synthetic routes towards synthesis of these acids. Herein, the novel synthesis of vinyl phosphonic acids (VPAs) and thei
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Koch, Horst, André Laschewsky, Helmut Ringsdorf, and Kang Teng. "Photodimerization and photopolymerization of amphiphilic cinnamic acid derivatives in oriented monolayers, vesicles and solution." Universität Potsdam, 1986. http://opus.kobv.de/ubp/volltexte/2008/1711/.

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Cinnamic acid moieties were incorporated into amphiphilic compounds containing one and two alkyl chains. These lipid-like compounds with photoreactive units undergo self-organization to form monolayers at the gas-water interface and bilayer structures (vesicles) in aqueous solutions. The photoreaction of the cinnamic acid moiety induced by 254 nm UV light was investigated in the crystalline state, in monolayers, in vesicles and in solution in organic solvents. The single-chain amphiphiles undergo dimerization to yield photoproducts with twice the molecular weight of the corresponding monomers
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fadhil, ali abd al-karim alkarim. "Reversed-phase and surfactant modified reversed-phase high and ultra-high performance liquid chromatography of phenolic and aliphatic carboxylic acids." Miami University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=miami1574428923192499.

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Lee, Chia-hsiu, and 李嘉修. "Enzymatic synthesis of Cinnamic Acid Derivatives." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/24397101373491962989.

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碩士<br>國立臺灣科技大學<br>化學工程系<br>93<br>Ferulic acid (4-hydroxy 3-methoxy cinnamic acid), which occurred naturally in many plants, has been shown to possess photoprotective, antioxidant, antitumor and hypertensive activities. Octyl methoxycinnamate (OMC) is the most widely used non-allergic sunscreen agent in the market. Most literatures reported low conversion and long reaction time in the syntheses of ethyl ferulate and OMC. In his study, Novozym 435 was selected as the catalyst for the syntheses of ethyl ferulate from ferulic acid and ethanol, and OMC from 4-methoxycinnamic acid and 2-ethyl hex
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Chou, Shan-Yi, and 周珊沂. "Antifungal Activity of Cinnamic Acid Derivatives." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/83506275868488364942.

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碩士<br>國立臺灣大學<br>森林環境暨資源學研究所<br>103<br>Cinnamon contains many aromatic compounds, among these compounds, trans-cinnamaldehyde has been proven to possess many bioactivities, and which belongs to trans-cinnamic acid derivatives in the biosynthesis pathway. The objective of this research is to find more cinnamic acid dervitaves to against plant pathogenic fungi, wood rotting fungi and mildew, expecting to reduce the damage from fungi diseases. In order to evaluate antifungal activities of cinnamaldehyde congeners, we classified them into three groups, cinnamic acid congeners, cinnamaldehyde congen
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Dias, Ana Luísa de Sousa e. Castro. "Evaluation of the anticancer activity of cinnamic acid derivatives targeting COX-2." Master's thesis, 2021. https://hdl.handle.net/10216/138473.

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Gomes, Joana Rodrigues da Silva. "Hybrids of Flavonoids and Cinnamic Acid Derivatives Combining Photoprotection and Antioxidant Activity." Master's thesis, 2021. https://hdl.handle.net/10216/137031.

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Telmesani, Reem. "Development of flow methodologies for the [2+2] photocycloaddition of cinnamic acid derivatives and biological exploration of truxinic acid derived scaffolds." Thesis, 2018. https://hdl.handle.net/2144/34788.

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Cinnamic acids and their derivatives are building blocks for cyclobutanes in many natural products. In nature, dimerization of these derivatives is thought to occur through a [2+2] photocycloaddition. Experimentally, efficient dimerization of these substrates using UV irradiation has predominantly been achieved in the solid state and is thought to be a result of stringent requirements for distance and orientation of the participating olefins. In the following pages a new strategy is presented which achieves [2+2] dimerization of these substrates in solution through the use of a bis-thiourea ca
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Lee, Fu-Wei, and 李馥葳. "The structure-activity relationship of cinnamic acid derivatives on reactive oxygen species scavenging and xanthine oxidase inhibitory activities." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/49468018915766371013.

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Tsai, Chiung-Man, and 蔡瓊滿. "Assessment of the Anti-invasion Potential and Mechanism of Select Cinnamic Acid Derivatives on Human Lung Adenocarcinoma Cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/30158564578255666199.

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博士<br>中山醫學大學<br>醫學研究所<br>102<br>Patients with lung adenocarcinoma are often diagnosed with metastasizing symptom and die of early and distal metastasis. Metastasis is made up of a cascade of interrelated and sequential steps, including cell adhesion, extracellular matrix degradation, cell movement, and invasion. Hence, substances carry the ability against one of the metastasis-associated steps could be a potential candidate for preventing tumor cells from metastasizing and prolonging life of cancer patients. Cinnamic acid (CA) was demonstrated to be such a candidate for human lung adenocarcino
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Books on the topic "Cinnamic acid derivatives"

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Buchner, Magnus R. Eta^2 Complexes of group 10 with cinnamic acid derivatives; spectroscopic properties, stability, reactivity and application potential as photo-switchable Catalysts. Logos Verlag Berlin, 2011.

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Book chapters on the topic "Cinnamic acid derivatives"

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Bassani, Dario. "The Dimerization of Cinnamic Acid Derivatives." In CRC Handbookof Organic Photochemistry and Photobiology, Volumes 1 & 2, Second Edition. CRC Press, 2003. http://dx.doi.org/10.1201/9780203495902.ch20.

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"The Dimerization of Cinnamic Acid Derivatives." In CRC Handbook of Organic Photochemistry and Photobiology, Volumes 1 & 2. CRC Press, 2003. http://dx.doi.org/10.1201/9780203495902-26.

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Rita Estevam, Maria, Estela Mesquita, and Magali Monteiro. "Phenolic Compounds Profile of Brazilian Commercial Orange Juice." In High Performance Liquid Chromatography - Recent Advances and Applications [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.109785.

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Orange juice is largely produced, exported and consumed in Brazil. It is an important source of bioactive compounds, such as flavonoids and phenolic acids, which are beneficial to the health of consumers. The aim of this work was to evaluate the phenolic compounds profile of commercial orange juice from Brazil using HPLC-DAD and UPLC-ESI-MS, and multivariate analysis. Forty-five phenolic compounds and one precursor were identified: cinnamic acid, 19 cinnamic acid derivatives, 8 flavanones and 18 flavones. Rutin, eriocitrin, narirutin, naringin, hesperidin, naringenin, nobiletin and tangeritin
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Biswas, Pronit, Rajesh Singh Yadav, and Juli Jain. "Neuroprotective Activities of Cinnamic Acids and their Derivatives." In Frontiers in Clinical Drug Research - CNS and Neurological Disorders. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815123319123110005.

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Neurodegenerative disorders are considered major global health problems associated with nervous system dysfunction, progressive neuronal cell loss with aging, and several pathological and sporadic factors. Parkinson’s disease, Alzheimer’s disease, Prion disease, Huntington’s disease, and multiple sclerosis are the main neurodegenerative diseases that raise significant concern among health scientists. The etiology of different neurodegenerative diseases is different, and they majorly affect the nervous system, including the brain, spinal cord, and peripheral nervous system. Neurodegenerative di
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Supuran, Claudiu T. "Coumarins as Carbonic Anhydrase Inhibitors." In Flavonoids and Phenolics. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815079098122010013.

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Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes and relevant drug targets with many medicinal chemistry applications. Their classes of inhibitors are in clinical use as diuretics, or drugs for the management of glaucoma, epilepsy, obesity, tumors and infectious diseases. Among the inhibitors discovered so far, coumarins constitute an interesting class. They undergo CA-catalyzed hydrolysis and act as “prodrug inhibitors”, forming 2-hydroxy-cinnamic acids, which bind at the entrance of the enzyme active site, which has a relevant variability of amino acid residues among the different CA
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Bourdon, Allen K., Greg Villareal, George Perry, and Clyde F. Phelix. "Alzheimer's and Parkinson's Disease Novel Therapeutic Target." In Research Anthology on Diagnosing and Treating Neurocognitive Disorders. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-3441-0.ch021.

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Thiazolidinedione (TZD) drugs (Takeda Pharmaceuticals and Metabolic Solutions Development Company) targeting inhibition of the mitochondrial pyruvate carrier (MPC) are currently being tested in clinical trials to prevent progression into mild cognitive impairment of Alzheimer's disease (AD) or in the pipeline to prevent neurodegeneration in Parkinson's disease (PD). These have Ki values in the µM range. This study was focused on identifying candidate drug precursors of the natural cinnamic acid products that might have good bioavailability in the nM ranges forming covalent thiol bonds with tar
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Narita, Yusaku, and Kuniyo Inouye. "Inhibition of Porcine Pancreas α-Amylase by Chlorogenic Acids from Green Coffee Beans and Cinnamic Acid Derivatives." In Coffee in Health and Disease Prevention. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-409517-5.00084-x.

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Banothu, Venkanna, and Addepally Uma. "Effect of Biotic and Abiotic Stresses on Plant Metabolic Pathways." In Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.99796.

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Plants are prone to encounter some environmental stresses that include both biotic and abiotic. Plants in response to these stress conditions alter their metabolism at the genetic level with consequential effects at the metabolite production. Phenolic compounds, which are secondary metabolites are one such chemical entity which plays a significant role in various physiological processes of the plant. They are mainly formed by three different types of metabolic pathways that produce phenyl propanoid derivatives, flavonoids, terpenoids based on the needs of the plant and the rate of their produc
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Daniela Lopes, Ana, Maria Graciela Iecher Faria Nunes, João Paulo Francisco, and Eveline Henrique dos Santos. "Potential Allelopathic Effect of Species of the Asteraceae Family and Its Use in Agriculture." In Asteraceae - Characterization, Recent Advances and Applications [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108709.

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Some species are capable of producing substances that affect seed germination, stimulating, or retarding this process, and can also suppress the development of other plants, acting as an antagonistic plant. This can occur naturally, through the release of exudates, or through the action of essential oil, extracts obtained from different parts of the plant, or plant residues with potential allelopathic action. The aim of this chapter is to present the main plant genera of the Asteraceae family with potential phytotoxic or allelopathic activity, with a suppressive effect on the growth of herbici
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Conference papers on the topic "Cinnamic acid derivatives"

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Quraishi, M. A. "Lauric Hydrazide Derivatives: New Class of Volatile Corrosion Inhibitors." In CORROSION 2002. NACE International, 2002. https://doi.org/10.5006/c2002-02319.

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Abstract The protection of metals against corrosion by means of volatile compounds is the most progressive method of fighting metallic corrosion. These inhibitors are used to protect metallic articles and equipment during storage and transportation. In view of this we have synthesized six organic volatile corrosion inhibitors (VCIs) using Lauric hydrazide with various acids such as cinnamic acid, succinic acid, nitrobenzoic acid, phthalic acid and maleic acid and evaluated their inhibiting action on corrosion of mild steel, copper, brass, zinc and aluminium by weight loss and potentiodynamic p
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Barmatov, Evgeny, Trevor Hughes, and Michaela Nagl. "Performance of Organic Corrosion Inhibitors on Carbon Steels and High Alloys in 4M Hydrochloric Acid." In CORROSION 2015. NACE International, 2015. https://doi.org/10.5006/c2015-05893.

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Abstract Matrix acidizing of oil and gas reservoirs is a widely established technique to increase hydrocarbon production. Strong mineral acids such as HCl or HCl/HF mixtures are injected into the well at high concentrations. For this application, corrosion inhibitors are enabling because uninhibited matrix acidizing treatment fluids would induce severe corrosion of downhole equipment. A broad range of organic film-forming corrosion inhibitors have been developed to retard the acid corrosion of coiled tubing and casing through which the acidizing fluids are injected. In this paper, the corrosio
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Annur, Rose, Nisa Urribah, Lia Meilawati, et al. "Brine Shrimp Lethality Assay of Ethyl Cinnamate Derivatives Synthesized by Microwave Irradiation of Cinnamic Acids with Ethyl Acetate." In BRIN’s International Conference for Health Research (ICHR). SCITEPRESS - Science and Technology Publications, 2024. https://doi.org/10.5220/0013471800004612.

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Zhao, Lei, Yuanbiao Tu, and Yuping Guo. "Synthesis of Cinnamic Acid Derivatives." In 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016). Atlantis Press, 2017. http://dx.doi.org/10.2991/emcm-16.2017.85.

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Meilawati, Lia, Endang Saepudin, and Teni Ernawati. "Antimicrobial activities of natural cinnamic acid and synthetic derivatives: Review." In XVII MEXICAN SYMPOSIUM ON MEDICAL PHYSICS. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0173189.

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VIANA, Thiago Silva, Pedro Henrique Fonseca DUQUE, Camila Prestes PINTO, et al. "SINTHESYS OF CINNAMIC ACID DERIVATIVES WITH CORROSION INHIBITION ACTIVITY FOR CARBON STEEL ALLOY." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013108103349.

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Ernawati, Teni. "Bioactivity of cinnamic acid derivatives as potential antibacterial agents based on in silico studies approach." In XVII MEXICAN SYMPOSIUM ON MEDICAL PHYSICS. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0172772.

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Hettiger, Theresa, Arup Sarkar, Jonas Hiller, et al. "Ligand-Driven Shifts in the Electronic Properties of CsPbBr₃ Nanocrystals: Role of Cinnamic Acid Derivatives in Oxidation and Charge Injection." In MATSUS Spring 2025 Conference. FUNDACIO DE LA COMUNITAT VALENCIANA SCITO, 2024. https://doi.org/10.29363/nanoge.matsusspring.2025.241.

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Reports on the topic "Cinnamic acid derivatives"

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Yibchok-anun, Sirintorn, and Nattaya Ngamrojanavanich. Structure-activity relationships of trans-cinnamic acid derivatives on inhibitions of alpha-glucosidase. Chulalongkorn University, 2004. https://doi.org/10.58837/chula.res.2004.86.

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Trans-Cinnamic acid and its derivatives were investigated for the a-glucosidase inhibitiory activity. 4-methoxy-trans-cinnamic acid and 4-methoxy-trans-cinnamic acid ethyl ester showed the highest potent inhibitory activity among those of trans-cinnamic acid derivatives. The presence of substituents at 4-position in trans-cinnamic acid derivatives. The presence of substituents at 4-position in trans-cinnamic acid altered the a-glucosidase inhibitory activity. Increasing of bulkiness and the chain length of 4-alkoxy substituents as well as the increasing of the electron withdrawing group have b
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Yibchok-anun, Sirinthorn, Wijit Banlunara, and Sirichai Adisakwattana. Antidiabetic effects, mechanisms of of p-methoxy-trans-cinnamic acid. Faculty of Veterinary Science, Chulalongkorn University, 2008. https://doi.org/10.58837/chula.res.2008.81.

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p-Methoxycinnamic acid (p-MCA) is a cinnamic acid derivative that shows various pharmacologic actions such as neuroprotective and hepatoprotective activities. To examine the insulinotropic activity of p-MCA, the perfused rat pancreas and a pancreatic β-cell line, INS-1 were used in the studies. P-MCA increased insulin secretion from the perfused rat pancreas and INS-1 cells in a concentration-dependent manner. In addition, p-MCA increased intracellular Ca²⁺ concentration ([Ca²⁺]i) in INS-1 cells. The p-MCA-induced insulin secretion and rise in [Ca²⁺]i were markedly inhibited in the absence of
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