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Journal articles on the topic 'Cinnamic acid derivatives'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Ruwizhi, Ngonidzashe, and Blessing Atim Aderibigbe. "Cinnamic Acid Derivatives and Their Biological Efficacy." International Journal of Molecular Sciences 21, no. 16 (2020): 5712. http://dx.doi.org/10.3390/ijms21165712.

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The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes and neurological disorders, among many, has been reported. Cinnamic acid is obtained from cinnamon bark. Its structure is composed of a benzene ring, an alkene double bond and an acrylic acid functional group making it possible to modify the aforementioned functionalities with a variety of compounds resulting in bioactive agents with enhanced efficacy. The nature of the substituents incorporated into cinnamic acid has been found to play a huge role in either enhancing or decreasing the biological ef

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2

Prakash, N. S., Devendra Reddy, R. Sundaram, et al. "Identification and quantification of cinnamic acid derivatives in Cichorium intybus seed and its extract by High- Performance Liquid Chromatography with Diode-Array Detector (HPLC-DAD) and Electrospray Ionization Mass Spectrophotometry (LC-MS/MS)." Universities' Journal of Phytochemistry and Ayurvedic Heights I, no. 34 (2023): 1–16. http://dx.doi.org/10.51129/ujpah-2022-34-1(1).

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A sensitive method coupling high-performance liquid chromatography (HPLC) with diode –array detector (DAD) and electrospray ionization mass spectrometry (MS) was optimized for separation, identification, and quantification of cinnamic acid derivatives in Cichorium intybus seed and its extract. Cinnamic acid derivatives such as chlorogenic acid, caffeic acid and Chicoric acid were quantified using respective standards. Apart from 4-o-Caffeoylqunic acid, other cinnamic acid derivative such as 3-o-caffeoylquinic acid was also identified and quantified by UV and MS/MS spectra and calculated as tot

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Wery, Guillaume, Karol Pastucha, Koen Robeyns, and Tom Leyssens. "The Inability of Metal Coordination to Control the Regioselectivity of Dimerization of Trans-Cinnamic Acid Derivatives." Crystals 14, no. 6 (2024): 530. http://dx.doi.org/10.3390/cryst14060530.

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Upon exposure to irradiation, trans-cinnamic acid can dimerize, producing truxinic and truxillic acids, regioisomers distinguished by the relative arrangement of acid and phenyl groups on the formed cyclobutane ring. Solid-state dimerization, governed by Schmidt’s specified conditions, hinges on the initial molecular setup. This study endeavors to manipulate the reaction’s outcome in the solid state. To achieve this, the target molecule was paired with metals (Ag, Cu) to modify molecular orientation in the solid. Investigated derivatives included para-hydroxy-trans-cinnamic acid, ortho-methoxy

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Ernawati, Teni, Maksum Radji, Muhammad Hanafi, Abdul Mun’im та Arry Yanuar. "Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents". Indonesian Journal of Chemistry 17, № 1 (2017): 151. http://dx.doi.org/10.22146/ijc.23572.

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This paper reviews biological activity of some cinnamic acid derivative compounds which are isolated from natural materials and synthesized from the chemical compounds as an agent of α-glucosidase inhibitors for the antidiabetic drug. Aegeline, anhydroaegeline and aeglinoside B are natural products isolated compounds that have potential as an α-glucosidase inhibitor. Meanwhile, α-glucosidase inhibitor class of derivatives of cinnamic acid synthesized compounds are p-methoxy cinnamic acid and p-methoxyethyl cinnamate. Chemically, cinnamic acid has three main functional groups: first is the subs

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5

Hasegawa, Toshio, Momohiro Hashimoto, Takashi Fujihara, and Hideo Yamada. "Aroma Profile of Galangal Composed of Cinnamic Acid Derivatives and Their Structure-Odor Relationships." Natural Product Communications 11, no. 10 (2016): 1934578X1601101. http://dx.doi.org/10.1177/1934578x1601101012.

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Cinnamic acid derivatives are important odorants due to their characteristic scent. Some fragrance materials, such as cinnamon bark, matsutake mushrooms, and Kaempferia galanga L. rhizome (galangal), contain several cinnamic acid derivatives as important odor constituents. The main odor constituent of galangal is ( E)-ethyl 4-methoxycinnamate, but the odor of this compound is different from that of galangal. We investigated the aroma profile of galangal using our previously described method that considers the intermolecular interactions of the odorant compounds with their receptors. Odorant co

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Peperidou, Aikaterini, Eleni Pontiki, Dimitra Hadjipavlou-Litina, Efstathia Voulgari, and Konstantinos Avgoustakis. "Multifunctional Cinnamic Acid Derivatives." Molecules 22, no. 8 (2017): 1247. http://dx.doi.org/10.3390/molecules22081247.

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7

Kabat, Małgorzata, Justyna Popiół, and Agnieszka Gunia-Krzyżak. "Cinnamic Acid Derivatives as Potential Multifunctional Agents in Cosmetic Formulations Used for Supporting the Treatment of Selected Dermatoses." Molecules 29, no. 23 (2024): 5806. https://doi.org/10.3390/molecules29235806.

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Cinnamic acid and its natural derivatives were primarily used in cosmetics as fragrance materials as well as skin and hair conditioners. Nowadays, not only natural but also synthetic cinnamic acid derivatives are used as active ingredients of cosmetic formulations. They still serve as fragrance ingredients but also as active ingredients supporting the treatment of selected dermatoses such as acne vulgaris, atopic dermatitis, and hyperpigmentation. They are also commonly used in anti-aging cosmetic formulations. On the other hand, several cinnamic acid derivatives used as fragrances in cosmetic

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8

Jacob, B. B., H. Baba, and J. O. Oluwadiya. "Synthesis, Characterization and evaluation of Anti-inflammatory and Antimicrobial Properties of some Cinnamic Acid Derivatives." Nigerian Journal of Pharmaceutical Research 16, no. 1 (2020): 1–8. http://dx.doi.org/10.4314/njpr.v16i1.1.

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Background: Cinnamic acid and derivatives are widely spread in plants. They are important intermediates in the synthesis of many aromatic compounds and are known to have diverse biological activities.Objectives: To synthesize, characterize and evaluate some cinnamic acid derivatives, for possible antimicrobial and anti-inflammatory activities.Material and methods: Different cinnamic acid derivatives were synthesized by Knoevenagel condensation reaction between malonic acid and various derivatives of benzaldehydes in the presence of pyridine and hydrochloric acid. The cinnamic acid epoxide was

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9

Hoai, N. T., Tran Thi Yen Ngoc, Nguyen Dang Nam та ін. "Effect oF β-Alanine on The Preparation of 4-Ethoxy-Cinnamic Acid". Open Materials Science Journal 12, № 1 (2018): 58–67. http://dx.doi.org/10.2174/1874088x01812010058.

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Objective:Cinnamic acid and its derivatives have a numerous potential applications in many different fields such as pharmacy, organic “building blocks”, and corrosion inhibitors.Method:It is well-known that Verley-Doebner modification is a high efficient method for the preparation of cinnamic acid derivaties, especially with the compounds containing electron-donating subtituents at para position in aromatic ring. In this paper, 4-ethoxy-cinnamic acid was synthesized according to Verley-Doebner reaction with the use of pyrine acting as catalyst and solvent. The effect of the β-alanine concentra

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10

Moreno-Robles, Antonio, Antonio Cala Peralta, Jesús G. Zorrilla, et al. "Structure−Activity Relationship (SAR) Study of trans-Cinnamic Acid and Derivatives on the Parasitic Weed Cuscuta campestris." Plants 12, no. 4 (2023): 697. http://dx.doi.org/10.3390/plants12040697.

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Cuscuta campestris Yunck. is a parasitic weed responsible for severe yield losses in crops worldwide. The selective control of this weed is scarce due to the difficult application of methods that kill the parasite without negatively affecting the infected crop. trans-Cinnamic acid is secreted by plant roots naturally into the rhizosphere, playing allelopathic roles in plant–plant communities, although its activity in C. campestris has never been investigated. In the search for natural molecules with phytotoxic activity against parasitic weeds, this work hypothesized that trans-cinnamic acid co

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Lorenzo, Daniel A., Sebastian J. K. Forrest, and Hazel A. Sparkes. "Crystal engineering: co-crystals of cinnamic acid derivatives with a pyridyl derivative co-crystallizer." Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 72, no. 1 (2016): 87–95. http://dx.doi.org/10.1107/s2052520615019678.

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A number of hydrogen-bonded co-crystals, consisting of a cinnamic acid derivative and a pyridyl co-crystallizer, have been synthesized and their properties investigated by X-ray diffraction. Samples were prepared by recrystallization or solvent drop grinding oftrans-cinnamic acid (1), 4-methylcinnamic acid (2), 4-methoxy cinnamic acid (3) or 3,4-methoxy cinnamic acid (4), with 4,4-dipyridyl (A),iso-nicotinamide (B) or nicotinamide (C). The X-ray single-crystal structures of seven novel co-crystals, obtained through recrystallization, are examined and the hydrogen-bonding interactions discussed

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12

Rudyanto, Marcellino, and Lanny Hartanti. "SYNTHESIS OF SOME CINNAMIC ACID DERIVATIVES: EFFECT OF GROUPS ATTACHED ON AROMATIC RING TO THE REACTIVITY OF BENZALDEHYDE." Indonesian Journal of Chemistry 8, no. 2 (2010): 226–30. http://dx.doi.org/10.22146/ijc.21626.

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Synthesis of cinnamic acid and its six derivatives has been done by employing Knoevenagel reaction. Benzaldehyde, 4-butylbenzaldehyde, 4-t-butylbenzaldehyde, 4-butoxybenzaldehyde, 4-phenylbenzaldehyde, 5-bromo-2,4-dimethoxybenzaldehyde, and 5-bromo-2,3-dimethoxybenzaldehyde were reacted with malonic acid in pyridine – piperidine to give cinnamic acid (85,3%), 4-butylcinnamic acid (69,3%), 4-t-butylcinnamic acid (77,7%), 4-butoxycinnamic acid (64,5%), 4-phenylcinnamic acid (65,5%), 5-bromo-2,4-dimethoxycinnamic acid (53,2%) and 5-bromo-2,4-dimethoxycinnamic acid (57,2%), respectively. It was di

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13

Katsuragi, Hisashi, Kei Shimoda, Ryohei Yamamoto, Kohji Ishihara, and Hiroki Hamada. "Glycosylation of Capsaicin Derivatives and Phenylpropanoid Derivatives Using Cultured Plant Cells." Biochemistry Insights 4 (January 2011): BCI.S6682. http://dx.doi.org/10.4137/bci.s6682.

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Biotransformations of capsaicinoids such as capsaicin and 8-nordihydrocapsaicin and phenylpropanoids such as cinnamic acid, p-coumaric acid, caffeic acid, and ferulic acid have been investigated using cultured plant cells. Capsain and 8-nordihydrocapsaicin were converted into the corresponding glycosides which are three glycosides respectively using the cultured cells of Catharanthus roseus. In a time-course study under sterile conditions, the changes in amounts of their reaction products were determined. Furthermore phenypropanoid, such as cinnamic acid, p-coumaric acid, caffeic acid and feru

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14

Hartanti, Lanny, and Henry Kurnia Setiawan. "INHIBITORY POTENTIAL OF SOME SYNTHETIC CINNAMIC ACID DERIVATIVES TOWARDS TYROSINASE ENZYME." Indonesian Journal of Chemistry 9, no. 1 (2010): 158–68. http://dx.doi.org/10.22146/ijc.21579.

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Cinnamic acid is one of known tyrosinase inhibitors. This study investigated the inhibition of tyrosinase activity of some cinnamic acid derivatives, i.e. 4-buthoxy-cinnamic acid, 4-n-butylcinnamic acid and 4-phenylcinnamic acid. Each inhibitor used in this research had the same type of inhibition towards enzymatic activity, i.e. mixed type inhibition of competitive and non competitive type. The potential sequence of tyrosinase inhibition based on the ratio of its IC50 compared to cinnamic acid, from the lowest to the highest were 4-buthoxycinnamic acid, 4-phenylcinnamic acid and 4-n-butylcinn

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15

Kustiana, Betty A., Galuh Widiyarti, and Teni Ernawati. "Recent advances in synthetic approaches for bioactive cinnamic acid derivatives." Beilstein Journal of Organic Chemistry 21 (May 28, 2025): 1031–86. https://doi.org/10.3762/bjoc.21.85.

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Cinnamic acid derivatives represent a significant class of biologically active compounds exhibiting a broad spectrum of activities, such as antifungal, antidengue, antimetastatic, antimicrobial, antibacterial, and anticancer properties. Their preparation has attracted considerable attention due to their versatile applications across the pharmaceutical, food, and chemical sectors. This review elucidates the functional groups of cinnamic acid that are instrumental in the rational design of biologically active derivatives. A comprehensive representative of recent advancements in synthetic methodo

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16

Pangaribowo, Dian Agung, Fathunnisa Fathunnisa, Ari Satia Nugraha, Ayik Rosita Puspaningtyas, and Indah Purnama Sary. "Structure Modification of Cinnamic Acid to (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one and Antioxidant Activity Test by DPPH Method." Borneo Journal of Pharmacy 7, no. 3 (2024): 254–63. http://dx.doi.org/10.33084/bjop.v7i3.6163.

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Antioxidants can protect cells from free radical damage by stabilizing them. One of the compounds that has antioxidant activity is cinnamic acid. Cinnamic acid and its derivatives have several activities: antibacterial, anticancer, and antioxidant. However, the ability of cinnamic acid to capture free radicals is still relatively low. One of the efforts that can be made to increase the antioxidant activity of cinnamic acid is to modify its structure. Structure modification is an effort to improve the pharmacological activity of a compound through chemical synthesis reactions. The cinnamic acid

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17

Taherkhani, Amir, Fateme Ghonji, Alireza Mazaheri, Mohammad Parsa Lohrasbi, Zeinab Mohamadi, and Zahra Khamverdi. "Identification of Potential Glucosyltransferase Inhibitors from Cinnamic Acid Derivatives Using Molecular Docking Analysis: A Bioinformatics Study." Avicenna Journal of Clinical Microbiology and Infection 8, no. 4 (2021): 145–55. http://dx.doi.org/10.34172/ajcmi.2021.27.

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Background: Dental caries is one of the most common oral chronic diseases. Streptococcus mutans is the main pathogenic bacteria playing a role in degrading the mineral texture of the teeth. Glucosyltransferase (GTFase) of S. mutans is responsible for producing glucan, which is the main exopolysaccharide found in the cariogenic biofilms. Further, previous studies have reported that cinnamic acid diminished biofilm formation of S. mutans. Therefore, we hypothesized that cinnamic acid and its derivatives might act as GTFase inhibitors. Methods: The binding affinity of a total of 12 plant-based co

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18

Mishra, Sonali, Shilpi Singh, Arif Ali, et al. "Microwave-assisted Single Step Cinnamic Acid Derivatization and Evaluation for Cytotoxic Potential." Current Pharmaceutical Biotechnology 21, no. 3 (2020): 236–43. http://dx.doi.org/10.2174/1389201020666191015161429.

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Background: Phenylpropylene biosynthesis pathway plays a crucial role in the vanillin and their derivative(s) production in the plants. The intermediate of vanillin synthesis i.e. cinnamic acid (CA) is converted into 2-Hydroxy 4-MethoxyBenzaldehyde (HMB) in Decalepis arayalpathra having a number of therapeutic value. Objective : Microwave-assisted modifications in cinnamic acid were planned for potential anticancer properties with better yield and efficiency. The present study also confirms the presence of HMB and its precursor i.e. cinnamic acid in D. arayalpathra tubers. Methods: We used a s

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19

Thakar, Snehal R., Pooja N. Dhamade, and Deepali A. Bansode. "CINNAMIC ACID AND ITS DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS." INDIAN DRUGS 60, no. 12 (2023): 7–19. http://dx.doi.org/10.53879/id.60.12.12905.

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Cinnamic acid is one of the naturally occurring chemical compounds present in various plants. It is obtained by both isolation from crude drugs, and by the synthetic route. In the last 10 years, many researchers have explored cinnamic acid for its pharmacological activities. Out of this anti-microbial and anti-tubercular activities are mainly focused in this review. Because of the unique structural features of cinnamic acid, various substitutions can be done. This review is an attempt to summarize the chemistry, reactions and pharmacological activities of cinnamic acid with a special focus on

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Lee, Gia-Sheu, Arief Widjaja, and Yi-Hsu Ju. "Enzymatic Synthesis of Cinnamic Acid Derivatives." Biotechnology Letters 28, no. 8 (2006): 581–85. http://dx.doi.org/10.1007/s10529-006-0019-2.

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Avanesyan, A. A., A. N. Pashkov, N. A. Simonyan, A. V. Simonyan, and O. V. Myachina. "Antiradical activity of cinnamic acid derivatives." Pharmaceutical Chemistry Journal 43, no. 5 (2009): 249–50. http://dx.doi.org/10.1007/s11094-009-0285-0.

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Zawiła, Tomasz, Denis Swolana, Marta Zawiła та Robert D. Wojtyczka. "Synergistic Interactions between Selected β-Lactam Antibiotics and Cinnamic Acid and Its Chosen Derivatives". Antibiotics 13, № 8 (2024): 710. http://dx.doi.org/10.3390/antibiotics13080710.

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Staphylococcus epidermidis, a component of human microbiota, may also cause life-threatening opportunistic infections. These are becoming increasingly common infections associated with the implantation of various implants. Due to the exhaustion of antibiotic resources, new substances with antimicrobial activity are being sought. The present study examined the antibacterial effect of cinnamic acid and its derivatives and their combinations with β-lactam antibiotics on the growth of Staphylococcus epidermidis strains isolated from vascular infections. The data obtained during the research indica

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Li, Yonglian, Kun Zhao, Zhidi Wu, et al. "Discovery of Cinnamic Acid Derivatives as Potent Anti-H. pylori Agents." Molecules 29, no. 19 (2024): 4548. http://dx.doi.org/10.3390/molecules29194548.

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Antibiotics are currently used for the treatment of Helicobacter pylori (H. pylori), which is confirmed to be the major cause of gastric disorders. However, the long-term consumption of antibiotics has already caused antibiotic resistance and side effects in vivo. Therefore, there is an emerging need for searching for safe and effective anti-H. pylori agents. Inspired by the excellent bioactivities of cinnamic acid, a series of cinnamic acid derivatives (compounds 1–30) were synthesized and determined for H. pylori inhibition. The initial screening revealed that compound 23, a 2,4-dinitro cinn

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Geetika, Vaisnav, K. Chakraborty Anup, and Karole Sarita. "Design, synthesis and evaluation of some novel derivatives of cinnamic acid as anti-inflammatory agents." World Journal of Biology Pharmacy and Health Sciences 14, no. 1 (2023): 088–96. https://doi.org/10.5281/zenodo.8037041.

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The role of Cinnamic acid derivatives as antioxidants, antimicrobial agents, antidiabetic drugs, anticancer drugs etc. is well reported. A thorough literature search revealed that the substitution on carboxylic acid group of Cinnamic acids by different amines imparts the potent conjugates. The quest for the design of effective anti-inflammatory drugs is still the primal focus of several research works world-wide owing to the side effects associated with the existing drugs. The side effects of the existing drugs are associated with the presence of the free carboxyl group in the molecules. In th

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Malekipour, Mohammad Hossein, Farzaneh Shirani, Shadi Moradi, and Amir Taherkhani. "Cinnamic acid derivatives as potential matrix metalloproteinase-9 inhibitors: molecular docking and dynamics simulations." Genomics & Informatics 21, no. 1 (2023): e9. http://dx.doi.org/10.5808/gi.22077.

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Matrix metalloproteinase-9 (MMP-9) is a zinc and calcium-dependent proteolytic enzyme involved in extracellular matrix degradation. Overexpression of MMP-9 has been confirmed in several disorders, including cancers, Alzheimer′s disease, autoimmune diseases, cardiovascular diseases, and dental caries. Therefore, MMP-9 inhibition is recommended as a therapeutic strategy for combating various diseases. Cinnamic acid derivatives have shown therapeutic effects in different cancers, Alzheimer′s disease, cardiovascular diseases, and dental caries. A computational drug discovery approach was performed

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Geetika Vaisnav, Anup K Chakraborty, and Sarita Karole. "Design, synthesis and evaluation of some novel derivatives of cinnamic acid as anti-inflammatory agents." World Journal of Biology Pharmacy and Health Sciences 14, no. 1 (2023): 088–96. http://dx.doi.org/10.30574/wjbphs.2023.14.1.0164.

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The role of Cinnamic acid derivatives as antioxidants, antimicrobial agents, antidiabetic drugs, anticancer drugs etc. is well reported. A thorough literature search revealed that the substitution on carboxylic acid group of Cinnamic acids by different amines imparts the potent conjugates. The quest for the design of effective anti-inflammatory drugs is still the primal focus of several research works world-wide owing to the side effects associated with the existing drugs. The side effects of the existing drugs are associated with the presence of the free carboxyl group in the molecules. In th

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Tian, Yuxin, Weirui Liu, Yi Lu, et al. "Naturally Occurring Cinnamic Acid Sugar Ester Derivatives." Molecules 21, no. 10 (2016): 1402. http://dx.doi.org/10.3390/molecules21101402.

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Rodríguez, Rocío B., Ramiro L. Zapata, María L. Salum, and Rosa Erra-Balsells. "Understanding the role played by protic ionic liquids (PILs) and the substituent effect for enhancing the generation of Z-cinnamic acid derivatives." Photochemical & Photobiological Sciences 19, no. 6 (2020): 819–30. http://dx.doi.org/10.1039/d0pp00072h.

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Cinnamic acids in their PIL form are more reactive than in their pure acid forms toward photoisomerization. This knowledge is successfully used for establishing an efficient and practical synthetic protocol for synthesizing Z-cinnamic derivatives.

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Wang, Rui, Wei Yang, Yiqing Fan, et al. "Design and synthesis of the novel oleanolic acid-cinnamic acid ester derivatives and glycyrrhetinic acid-cinnamic acid ester derivatives with cytotoxic properties." Bioorganic Chemistry 88 (July 2019): 102951. http://dx.doi.org/10.1016/j.bioorg.2019.102951.

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Voronkov, Andrey V., Dmitry I. Pozdnyakov, Similla L. Adjiahmetova, Nadezhda M. Chervonnaya, Victoria M. Rukovitsina, and Eduard "T" Oganesyan. "Influence of some cinnamic acid derivatives on changes of the tricarboxylic acid cycle enzymes activity in rats under brain ischemia conditions." Medical academic journal 20, no. 2 (2020): 27–32. http://dx.doi.org/10.17816/maj33994.

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The aim of the study was to assess the effect of certain derivatives of cinnamic acids on changes of the tricarboxylic acid cycle enzymes activity under experimental cerebral ischemia. Materials and methods. Brain ischemia was modeled by irreversible right-sided coagulation of the middle cerebral artery. Test compounds: 4-hydroxy-3,5-ditretbutyl cinnamic acid, coumaric, coffee, synapic, cinnamic, 4-hydroxycinnamic and ferulic acids, as well as a reference drug succinic acid was administered at a dose of 100 mg / kg per os for 3 days after the reproduction of ischemia. Then, changes in th

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Tsopka, Ioanna-Chrysoula, and Dimitra Hadjipavlou-Litina. "Hybrids as NO Donors." International Journal of Molecular Sciences 22, no. 18 (2021): 9788. http://dx.doi.org/10.3390/ijms22189788.

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Cinnamic acid and its derivatives have been studied for a variety of biological properties, including anti-inflammatory, antioxidant, anticancer, antihypertensive, and antibacterial. Many hybrids of cinnamic derivatives with other bioactive molecules have been synthesized and evaluated as nitric oxide (NO) donors. Since NO plays a significant role in various biological processes, including vasodilation, inflammation, and neurotransmission, NO donor groups are incorporated into the structures of already-known bioactive molecules to enhance their biological properties. In this review, we present

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B. Bakare, S. "Synthesis and biological evaluation of some hybrid 2-quinolinone derivatives containing cinnamic acid as anti-breast cancer drugs." Bulletin of the Chemical Society of Ethiopia 35, no. 3 (2022): 551–64. http://dx.doi.org/10.4314/bcse.v35i3.7.

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ABSTRACT. A new series of hybrid 2-quinolinone derivatives were synthesized by using 7-hydroxy-4-methyl-1-amino-quinolin-2-one (2) and cinnamic acid. Hybrid halogenated 2-quinolinone derivatives (3-(7-hydroxy-4-methyl-3,6,8-tribromo-2-oxo-2H-quinolin-1-ylamino)-3-phenyl acrylic acid (4) and 3-(7-acetoxy-4-methyl-3,6,8-tribromo-2-oxo-1H-quinolin-1-ylamino)-3-phenyl acrylic acid (7)) were prepared via the halogenation of 3-(7-hydroxy-4-methyl-2-oxo-2H-quinolin-1-ylamino)-3-phenyl acrylic acid (3) with bromine to give compound 4 with acetic anhydride led to the formation of hydride halogenated 2-

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Rao, Pasupuleti Visweswara, and Siew Hua Gan. "Cinnamon: A Multifaceted Medicinal Plant." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/642942.

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Cinnamon (Cinnamomum zeylanicum,and Cinnamon cassia), the eternal tree of tropical medicine, belongs to the Lauraceae family. Cinnamon is one of the most important spices used daily by people all over the world. Cinnamon primarily contains vital oils and other derivatives, such as cinnamaldehyde, cinnamic acid, and cinnamate. In addition to being an antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer, lipid-lowering, and cardiovascular-disease-lowering compound, cinnamon has also been reported to have activities against neurological disorders, such as Parkinson’s and Alzhei

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Alex, Sheeba Baby, Ullas Mohan, and M. S. Latha. "ASSESSMENT OF ANTHELMINTIC ACTIVITY OF CINNAMIC ACID AND ITS THREE ANALOGS: A COMBINED INVITRO AND INSILICO STUDY." Acta Pharma Reports 4, no. 1 (2024): 12–19. https://doi.org/10.51470/apr.2025.04.01.12.

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Concern over anthelmintic resistance is a global issue, and researchers are exploring plant-derived compounds for their effectiveness against gastrointestinal nematodes. Cinnamic acid and its primary hydroxy derivatives, including p-coumaric, ferulic, and caffeic acids, are phenolic compounds that are abundant in plants and possess numerous therapeutic properties. This investigation aimed to determine the anthelmintic properties of these compounds.Anthelmintic potential of cinnamic acid and its analogs were investigated on the Indian earthworm species, PheretimaPosthuma.The duration required f

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Nimse, Satish Balasaheb, Dilipkumar Pal, Avijit Mazumder, and Rupa Mazumder. "Synthesis of Cinnamanilide Derivatives and Their Antioxidant and Antimicrobial Activity." Journal of Chemistry 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/208910.

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The amide derivatives of cinnamic acid were synthesized and their antimicrobial and antioxidant activities were investigated. The investigation of antimicrobial potentials of the compounds demonstrated a strong activity against 21 bacterial strains comprising Gram-positive and Gram-negative bacteria. Compounds2a,2b, and3bshowed strong antimicrobial activity against all microorganisms with the pMIC value ranging from 2.45 to 3.68. Compounds2a,3a, and3bdemonstrated strong antioxidant activity with % inhibition of the DPPH radical of 51% (±1.14), 41% (±1.01), and 50% (±1.23), respectively. These

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Kraus, Christine A., and Gerhard Spiteller. "Phenolic Compounds from Ageing Shoots of Picea abies." Zeitschrift für Naturforschung C 52, no. 5-6 (1997): 308–12. http://dx.doi.org/10.1515/znc-1997-5-605.

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Abstract The influence of ageing on the amount and composition of phenolic compounds and their glucosides was studied in one to five-year-old shoots of Picea abies. The total content of phenolics increased remarkably within the first two years of growth. In this period cinnamic acid derivatives were dominating, but beginning with the end of the first vegetation period a dramatic increase of acetophenones was observed. Obviously at the end of the first vegetation period the cinnamic acid derivatives are subjected to oxidation resulting in an increase of acetophenones.

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Ahmadi, Ali, Mahdyieh Naziri, Fatemeh Fallahpour, et al. "Therapeutic potential of cinnamon for neurological disorders: A mini-review." Neurology Asia 27, no. 1 (2021): 1–17. http://dx.doi.org/10.54029/2022uxk.

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An increasing amount of evidence suggests that cinnamon, due to its rich source of polyphenol content, may exert antioxidant and anti-inflammatory properties, hence could be used in the treatment of variety of diseases. in this regard, many studies explored the effects of cinnamon and its bioactive components (coumarin, cinnamic acid, cinnamaldehyde and type A procyanidin polymers) on various neurological diseases including Parkinson’s disease, neuroinflammation, multiple sclerosis, brain injury, Alzheimer’s disease, migraine, and hyperactivity. The present study attempts to review available d

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YAMAGUCHI, Kazuo, Emi HAYASHI, and Yasukazu OHKATSU. "Cinnamic Acid Derivatives. (Part 2). Relation between Antioxidative Activities and Structures of Cinnamic Acid Drivatives." Journal of The Japan Petroleum Institute 39, no. 4 (1996): 279–84. http://dx.doi.org/10.1627/jpi1958.39.279.

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Malheiro, Maillard, Borges, and Simões. "Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives." Molecules 24, no. 21 (2019): 3918. http://dx.doi.org/10.3390/molecules24213918.

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Surface disinfection is of utmost importance in the prevention of bacterial infections. This study aims to assess the ability of ten phytochemicals and related derivatives as potentiators of two commonly used biocides—cetyltrimethylammonium bromide (CTAB) and lactic acid (LA). LA in combination with cinnamic, hydrocinnamic, α-methylcinnamic, and α-fluorocinnamic acids had a factional inhibitory concentration index (FICI) ≤ 1 for Escherichia coli and Staphylococcus aureus. Several phytochemicals/derivatives in combination with biocides improved the biocidal efficacy against early sessile bacter

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Hussain, Riaz, Bakhat Ali, Muhammad Imran, and Abdul Malik. "Thymofolinoates A and B, New Cinnamic Acid Derivatives from Euphorbia thymifolia." Natural Product Communications 7, no. 10 (2012): 1934578X1200701. http://dx.doi.org/10.1177/1934578x1200701025.

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Two new cinnamic acid derivatives, thymofolinoates A (1) and B (2) have been isolated from the chloroform soluble fraction of Euphorbia thymifolia and their structures assigned from 1H and 13C NMR spectra, DEPT and by 2D COSY, HMQC and HMBC experiments. In addition, p-hydroxy cinnamic acid (3), 5-hydroxy-6,7,8,4′-tetramethoxy flavone (4), and 5-hydroxy-3′,4′,6,7,8-pentamethoxy flavone (5) have also been isolated for the first time from this species.

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Ramazani, Ali, Yavar Ahmadi, and Fatemeh Zeinali Nasrabadi. "Four-component Synthesis of 1,3,4-Oxadiazole Derivatives from (N-Isocyanimino)triphenylphosphorane, (E)-Cinnamic Acids, Acetaldehyde and Secondary Amines." Zeitschrift für Naturforschung B 66, no. 2 (2011): 184–90. http://dx.doi.org/10.1515/znb-2011-0211.

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The 1 : 1 iminium intermediate, generated by the addition of a secondary amine to acetaldehyde is trapped by the (N-isocyanimino)triphenylphosphorane in the presence of an (E)-cinnamic acid derivative, leading to the formation of the corresponding iminophosphorane intermediate. Disubstituted 1,3,4-oxadiazole derivatives are formed via intramolecular aza-Wittig reaction of the iminophosphorane intermediates. The reactions were completed under neutral conditions at room temperature, and the corresponding disubstituted 1,3,4-oxadiazole derivatives were produced in excellent yields.

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Nouni, Christina, Panagiotis Theodosis-Nobelos, and Eleni A. Rekka. "Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives." Molecules 28, no. 18 (2023): 6732. http://dx.doi.org/10.3390/molecules28186732.

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Oxidative stress and hyperlipidemia are important factors for the initiation and progression of various cell degenerative pathological conditions, including cardiovascular and neurological diseases. A series of cinnamic acid-derived acids, such as ferulic acid, sinapic acid, 3,4-dimethoxycinnamic acid, p-coumaric acid, and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid, were esterified or amidated with various moieties, bearing different biological activities, and evaluated. The antioxidant and radical scavenging abilities of the compounds via inhibition of rat hepatic microsomal membra

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Neganova, M. E., V. Semenov, M. Semenova, et al. "Bioisosteric Analogues of Cinnamic Acid as Effective Neuroprotectors." Biomedical Chemistry: Research and Methods 1, no. 3 (2018): e00052. http://dx.doi.org/10.18097/bmcrm00052.

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Compounds that act on mitochondrial functions are considered as promising drugs for the treatment of neurodegenerative diseases and age-related dementias. As a basis for the creation of such potential drugs, bioisosteric cinnamic acid analogs and polymethoxybenzene derivatives were selected. Derivatives of cinnamic acid have a wide range of biological activities, which can be important for drugs aimed at the treatment of neurodegenerative diseases, in particular Alzheimer′s disease. In this work, the neuroprotective activity of bioisosteric cinnamic acid analogs and polymethoxybenzene derivati

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Czuba, Z., W. Krol, S. Scheller, and J. Shani. "Effect of Cinnamic and Acrylic Acids′ Derivatives on Luminol-Enhanced Chemiluminescence of Neutrophils." Zeitschrift für Naturforschung C 47, no. 9-10 (1992): 753–56. http://dx.doi.org/10.1515/znc-1992-9-1019.

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Fourteen derivatives of cinnamic and acrylic acids were evaluated for their ability to modulate chemiluminescence, evoked by neutrophils that had been exposed to luminol and phorbolmyristate- acetate. Compounds with one or two hydroxyl groups on the phenyl ring demonstrated significant inhibition of the chemiluminescence, but this inhibition was diminished by methoxylation. Saturation of the double bond in the aliphatic chain of cinnamic acid at C 6 - enhanced the chemiluminescence to a small degree. All three acrylic acid derivatives demonstrated a marked inhibition of the luminol chemilumine

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Khalfaoui, Ouafa, Adel Beghidja, Jérôme Long, et al. "Cinnamic acid derivative rare-earth dinuclear complexes and one-dimensional architectures: synthesis, characterization and magnetic properties." Dalton Transactions 46, no. 12 (2017): 3943–52. http://dx.doi.org/10.1039/c7dt00326a.

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Rasyid, Herlina, Teni Ernawati, and Indah Muthmainnah Monoarfa. "2-Cinnamamido-4-Methylpentanamide and N-(2-Hydroxypropanoyl)Cinnamamide: Synthesis, Characterization, and Molecular Docking Studies Through PBP2a Protein." Molekul 19, no. 2 (2024): 262. http://dx.doi.org/10.20884/1.jm.2024.19.2.10154.

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ABSTRACT. Cinnamic acid has been found in several types of plants and has a diverse spectrum of bioactivity. Derivatization of cinnamic acid related to the improving bioactivity of a compound. Cinnamic acid can be found as an acid or in conjugated form with amides, esters, aldehydes. This research focus on the synthesis of amide derivatives of cinnamic acid to improve the bioactivity. Two compounds namely 2-cinnamamido-4-methylpentanamide (1a) and N-(2-hydroxypropanoyl)cinnamamide (1b) were carried out through amidation reaction using carbodiimide coupling reagent for 24 hours. The synthesized

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Fotopoulos, Ioannis, Eleni Pontiki, and Dimitra Hadjipavlou Litina. "Targeting Inflammation with Conjugated Cinnamic Amides, Ethers and Esters." Letters in Drug Design & Discovery 17, no. 1 (2019): 3–11. http://dx.doi.org/10.2174/1570180816666181129125511.

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Background: Cinnamic acid is a key intermediate in shikimate and phenylpropanoid pathways. It is found both in free form, and especially in the form of esters in various essential oils, resins and balsams which are very important intermediates in the biosynthetic pathway of several natural products. The cinnamic derivatives play a vital role in the formation of commercially important intermediate molecules which are necessary for the production of different bioactive compounds and drugs. Different substitutions on basic moiety lead to various biological activities. Furthermore, combination of

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Wei-Jun, Huang, Chen Su-Ming, Tan Fu, and Yang Zhen-Xiang. "Study on Thermodynamic Characteristics of Cinnamic Acid Derivatives." Acta Physico-Chimica Sinica 10, no. 02 (1994): 151–53. http://dx.doi.org/10.3866/pku.whxb19940212.

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Stankyavichyus, A. P., L. M. M. Stankyavichene, M. S. Sapragonene, L. V. Korobchenko, E. I. Boreko, and G. V. Vladyko. "Synthesis and antiviral activity of cinnamic acid derivatives." Pharmaceutical Chemistry Journal 22, no. 12 (1988): 896–900. http://dx.doi.org/10.1007/bf00771641.

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Sova, M. "Antioxidant and Antimicrobial Activities of Cinnamic Acid Derivatives." Mini-Reviews in Medicinal Chemistry 12, no. 8 (2012): 749–67. http://dx.doi.org/10.2174/138955712801264792.

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