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Journal articles on the topic 'Cinnamyl group'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Shinde, Sunil B., and Raj M. Deshpande. "Catalytic Hydrogenation of Cinnamic Acid and Salicylic Acid." Asian Journal of Chemistry 32, no. 2 (2019): 339–41. http://dx.doi.org/10.14233/ajchem.2020.22393.

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Hydrogenation of cinnamic acid and salicylic acid was carried out using 5 %Ru/C, 5 % Pd/C and Ru-Sn/Al2O3 catalyst at 493 K and 6.89 MPa of hydrogen partial pressure. Ru-Sn/Al2O3 catalyst was found to be active for hydrogenation -COOH group to give cinnamyl alcohol. The selectivity to cinnamyl alcohol was low (15 %) as absolute inhibition of C=C bond hydrogenation in cinnamic acid is challenging. 5 %Pd/C catalyst was found to hydrogenate C=C bond and aromatic ring in cinnamic acid. 5 %Ru/C catalyst was found to be least selective catalyst as it hydrogenated C=C bond, aromatic ring and -COOH gr

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2

Ravilla, Lokesh, N. Venkata subba Naidu, Shalini Dogra, et al. "Opioid Receptor Modulators with a Cinnamyl Group." Journal of Medicinal Chemistry 60, no. 15 (2017): 6733–50. http://dx.doi.org/10.1021/acs.jmedchem.7b00643.

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3

Kaur, Pushpinder, Pralay Das, Abha Chaudhary та Bikram Singh. "Naturally Occurring Limonene to Cinnamyl-type γ-Butyrolactone Substituted Aldol Condensation Derivatives as Antioxidant Compounds". Natural Product Communications 7, № 9 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700903.

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A method has been developed for the synthesis of γ-butyrolactone substituted cinnamyl type Aldol condensation products under milder proline and triethylamine basic conditions. The antioxidant activity of all the synthesized compounds was assessed using three different assays. The cinnamyl type derivatives of γ-butyrolactone bearing an -OH group in the benzene ring exhibited excellent antioxidant activity.

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4

Ho, Su-Chen, Yi-Huang Chang та Ku-Shang Chang. "Structural Moieties Required for Cinnamaldehyde-Related Compounds to Inhibit Canonical IL-1β Secretion". Molecules 23, № 12 (2018): 3241. http://dx.doi.org/10.3390/molecules23123241.

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Suppressing canonical NOD-like receptor protein 3 (NLRP3) inflammasome-mediated interleukin (IL)-1β secretion is a reliable strategy for the development of nutraceutical to prevent chronic inflammatory diseases. This study aimed to find out the functional group responsible for the inhibitory effects of cinnamaldehyde-related compounds on the canonical IL-1β secretion. To address this, the suppressing capacities of six cinnamaldehyde-related compounds were evaluated and compared by using the lipopolysaccharide (LPS)-primed and adenosine 5′-triphosphate (ATP)-activated macrophages. At concentrat

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Benkovics, Gabor, Ondrej Hodek, Martina Havlikova та ін. "Supramolecular structures based on regioisomers of cinnamyl-α-cyclodextrins – new media for capillary separation techniques". Beilstein Journal of Organic Chemistry 12 (19 січня 2016): 97–109. http://dx.doi.org/10.3762/bjoc.12.11.

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This work focuses on the preparation and application of supramolecular structures based on mono-cinnamyl-α-cyclodextrins (Cin-α-CD). Pure regioisomers of Cin-α-CD having the cinnamyl moiety at the 2-O- or at the 3-O-position, respectively, were prepared, characterized and applied in capillary electrophoresis as additives to the background electrolyte. These new monomer units with a potential to self-organize into supramolecular structures were synthesized via a straightforward one-step synthetic procedure and purified using preparative reversed-phase chromatography allowing a large scale separ

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6

Fleming, S. A., L. Renault, E. C. Grundy, and J. A. Pincock. "The photochemistry of ring-substituted cinnamyl acetates." Canadian Journal of Chemistry 84, no. 9 (2006): 1146–54. http://dx.doi.org/10.1139/v06-140.

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The photochemistry of the (E)-cinnamyl acetates ((E)-1-aryl-3-propenyl acetates, 8a–8e) with substituents H, 4-CH3O, 3-CH3O, 4-CF3, and 3-CF3, respectively, was examined in both cyclohexane and methanol solvents. Alkene isomerization (E to Z) occurred more efficiently than other reactions and evidence is presented that this process occurs from the excited triplet state. In a slower process, 1,3-migration of the acetoxy group led to the rearranged 3-aryl-3-propenyl acetate isomers (9a–9e) as the major pathway, particularly in cylohexane. In methanol, the isomeric ethers 3-aryl-3-methoxypropene

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7

Le, Xuan Minh, Khanh Duy Nguyen, Khoa Dang Tran, Tuan Quoc Tran, and Nghiep Dai Ngo. "Inhitive ability collagenase of N-(cinnamyl) chitooligosaccharide derivative." Science and Technology Development Journal 20, K3 (2017): 83–91. http://dx.doi.org/10.32508/stdj.v20ik3.1096.

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Chitooligosaccharides (COS) with molecular weight 4633 Da and 84.67% of deacetylation were synthesized by hydrolysis of chitosan by cellulase at room temperature (33 ± 1 ° C). This COS, then, were chemically modified by grafting cinnamaldehyde at amino groups on the COS. Derivatives of N- (cinnamyl) chitooligosaccharides (CCOS) synthesized with 50.64% of yield and 72.22% of extent of substitution had inhibitory activity enzyme collagenase (a group of matrix metalloproteinases, enzyme family related to metastatic ability of cancer). Compared with the positive control, 58.23% of the effective to

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8

Chen, Guanfan, Chenzhong Cao, Bin Sheng, Yun Zhu, Zhenxing Wu та Xiangsi Wu. "Substituent effect study onδcvalues of the bridge group carbons in disubstituted cinnamyl aniline series". Journal of Physical Organic Chemistry 25, № 10 (2012): 828–34. http://dx.doi.org/10.1002/poc.2923.

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9

Ichikawa, Yoshiyasu, Tomoyuki Hasegawa, Takahiro Minami, et al. "Further Development of the Tin-Catalyzed Transcarbamoylation Reaction." Synthesis 52, no. 16 (2020): 2373–78. http://dx.doi.org/10.1055/s-0040-1708020.

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Studies carried out to further develop tin-catalyzed transcarbamoylation reactions demonstrated that transcarbamoylation of cinnamyl alcohol in the context of allyl cyanate-to-isocyanate rearrangement can be efficiently carried out on a ten-gram scale and that tin-catalyzed transcarbamoylation is a valuable alternative to the method using trichloroacetyl isocyanate. In addition, methyl carbamate was found to be an economical carabamoyl donor in tin-catalyzed transcarbamoylation, which showed broad functional group tolerance and allowed a streamlined workup procedure. Finally, a unique synthe

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10

Hashimoto, Toru, Kei Funatsu, Atsufumi Ohtani, Erika Asano, and Yoshitaka Yamaguchi. "Cross-Coupling Reaction of Allylic Ethers with Aryl Grignard Reagents Catalyzed by a Nickel Pincer Complex." Molecules 24, no. 12 (2019): 2296. http://dx.doi.org/10.3390/molecules24122296.

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A cross-coupling reaction of allylic aryl ethers with arylmagnesium reagents was investigated using β-aminoketonato- and β-diketiminato-based pincer-type nickel(II) complexes as catalysts. An β-aminoketonato nickel(II) complex bearing a diphenylphosphino group as a third donor effectively catalyzed the reaction to afford the target cross-coupled products, allylbenzene derivatives, in high yield. The regioselective reaction of a variety of substituted cinnamyl ethers proceeded to give the corresponding linear products. In contrast, α- and γ-alkyl substituted allylic ethers afforded a mixture of

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11

Zhang, Hua, Jian Ye, Xu Wang, Zongiun Liu, Tao Chen, and Junqing Gao. "Therapeutic Effect and Mechanism of Cinnamyl Alcohol on Myocardial Ischemia-Reperfusion Injury." Evidence-Based Complementary and Alternative Medicine 2022 (May 31, 2022): 1–10. http://dx.doi.org/10.1155/2022/5107948.

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Objective. To investigate the effect of CA on autophagy and its molecular mechanism after myocardial ischemia/reperfusion injury (MI/RI). Methods. The MI/RI model was established by the ligation of the left anterior descending coronary artery with ischemia and reperfusion. In vitro cell models were established using hypoxia/reoxygenation. Western blot was used to determine the expression levels of beclin-1, P62, and LC3 II. The expression levels of IL-1β, IL-6, TNFα, and apoptosis-related genes Bax, Cyt-c, and Bcl-2 were detected by qRT-PCR. Cell activity was detected by CCK-8. Apoptosis was d

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12

Li, Hang, Rong Yang, Yating Peng, Hongwei Cao, and Jinchun Li. "Preparation of liquid crystalline polymer networks containing a cinnamyl group in the main chain with tunable thermal actuation behavior." Journal of Polymer Science Part B: Polymer Physics 57, no. 14 (2019): 904–11. http://dx.doi.org/10.1002/polb.24845.

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13

SANJAY, TALUKDAR, and BANERJI ASOKE. "Design and Development of New Chemical Reactions via Low-valent Titanium induced Cleavage of Carbon - Heteroatom Bonds." Journal of Indian Chemical Society Vol. 74, Nov-Dec 1997 (1997): 842–47. https://doi.org/10.5281/zenodo.5900308.

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Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai-400 085 <em>Manuscript received 13 August 1997</em> Low-valent titanium (LVT)-induced regioselective cleavage of <em>N</em>-aryl methyl bonds in preference to <em>N</em>-alkyl/aryl counterparts in N-arylmethylamines has been examined in detail and culminated in the design and development of new reactions, viz. novel approach to deprotection of <em>N</em>-benzylamines, reductive deoxygenation of carbonyls to methylenes and reductive amination of carbonyls under neutral conditions-all involving a known bonding change, viz. the directed

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14

Kanberga-Silina, K., A. Jansons, and Dainis Rungis. "Expression of three phenylpropanoid pathway genes in Scots pine (Pinus sylvestris L.) in open-pollinated families with differing relative wood densities during early and late wood formation." Silvae Genetica 64, no. 1-6 (2015): 148–59. http://dx.doi.org/10.1515/sg-2015-0014.

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Abstract Wood volume and quality are the most important aspects of commercial forestry production, and studies of wood formation are important in order to increase the value and efficiency of forestry production. The phenylpropanoid pathway produces various compounds with diverse functions both for plant defence against biotic and abiotic stress as well as structural development. One of the main roles is monolignol production for lignin biosynthesis, which is a crucial aspect of wood formation. For this study three candidate genes involved in lignin biosynthesis were selected: phenylalanine am

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15

Ficeri, Vlastimír, Peter Kutschy, Milan Dzurilla, and Ján Imrich. "[3,3]- Versus [1,3]-Sigmatropic Rearrangement of O-Substituted Allyl N-Acylmonothiocarbamates." Collection of Czechoslovak Chemical Communications 59, no. 12 (1994): 2650–62. http://dx.doi.org/10.1135/cccc19942650.

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Substituted allylic alcohols (2-buten-1-ol, 1-buten-3-ol, cinnamyl alcohol and 3-methyl-2-buten-1-ol) react with acyl isothiocyanates (4-chlorobenzoyl, 2,6-difluorobenzoyl, 3-phenylpropenoyl, 2-thienocarbonyl, 3-chloro-2-thienocarbonyl and 3-chloro-2-benzo[b]thienocarbonyl isothiocyanate) with the formation of highly reactive O-substituted allyl N-acylmonothiocarbamates, which either spontaneously or by heating in boiling benzene undergo [3,3]-sigmatropic rearrangement to S-substituted allyl N-acylmonothiocarbamates. The structure of S-esters with isomerized allylic group affords the unequivoc

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16

Luo, Weihua, Tinghui Chen, Xiao Gong, Jingjing Chen, Wei Zhou, and Jihua Li. "Hydrogen Sulfide Improves Postharvest Quality of Okra (Abelmoschus esculentus (L.) Moench) Pods by Enhancing Antioxidant Capacity and Delaying Lignification." Foods 13, no. 16 (2024): 2617. http://dx.doi.org/10.3390/foods13162617.

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Okra (Abelmoschus esculentus (L.) Moench) pod storage is challenging due to its high water content and tendency to lignify. Sodium hydrosulfide (NaHS) served as an H2S donor in this investigation. Compared with the control group, the group treated with 0.5 mmol/L NaHS solution effectively maintained the appearance quality, and its weight loss was only 6.21% at 20 days. The H2S treatment not only preserved tissue nutrients but also significantly enhanced catalase (CAT), ascorbic acid peroxidase (APX), and superoxide dismutase (SOD) activities while decreasing oxidant damage. In addition, H2S sl

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17

Mieriņa, Inese, Darja Kostjuņina, Dārta Zelma Skrastiņa, and Mara Jure. "Synthesis and Antiradical Activity of 2-Arylidenemalonic Acid Dianilides." Key Engineering Materials 850 (June 2020): 230–35. http://dx.doi.org/10.4028/www.scientific.net/kem.850.230.

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The most common cinnamoyl anilines are avenanthramides, which are natural antioxidants found in oats. This is a rather uncommon and not well-investigated group of antioxidants. This paper deals with 2-arylidenemalonic acid dianilides – cinnamoyl anilines which are decorated with an additional arylaminocarbonyl moiety at α-position of double bond. The DPPH scavenging activity of the title compounds is slightly lower in comparison to the corresponding cinnamoyl anilines. On the other hand, the title dianilides are more active than cinnamic acid anilides containing an additional carboxylic group

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18

Meng, Liubei, Rui Shi, Qiong Wang, and Shu Wang. "Analysis of Floral Fragrance Compounds of Chimonanthus praecox with Different Floral Colors in Yunnan, China." Separations 8, no. 8 (2021): 122. http://dx.doi.org/10.3390/separations8080122.

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In order to better understand the floral fragrance compounds of Chimonanthus praecox belonging to genus Chimonanthus of Chimonanaceae in Yunnan, headspace solid-phase microextraction combined with gas chromatography-mass spectrometry was used to analyze these compounds from four C. praecox plants with different floral colors. Thirty-one types of floral fragrance compounds were identified, among which terpenes, alcohols, esters, phenols, and heterocyclic compounds were the main compounds. Interestingly, the floral fragrance compounds identified in the flowers of C. praecox var. concolor include

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19

Menichetti, Stefano, та Charles J. M. Stirling. "ChemInform Abstract: Phenyl Group Acceleration of [1,4] Carbon-to-Oxygen Silicon-Mediated Elimination-Rearrangement in β-Silyl Sulfones. Synthesis of O-Silylated Cinnamyl Alcohols." ChemInform 33, № 20 (2010): no. http://dx.doi.org/10.1002/chin.200220142.

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20

Guan, Yeqing, Xiaoli Qin, Chuangqi Wei, et al. "Influence of Bagging on Fruit Quality, Incidence of Peel Browning Spots, and Lignin Content of ‘Huangguan’ Pears." Plants 13, no. 4 (2024): 516. http://dx.doi.org/10.3390/plants13040516.

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The ‘Huangguan’ pear is one of the high-quality pear cultivars produced in China. However, the bagged fruit of the ‘Huangguan’ pear often suffers from peel browning spots after rain during their mature period. In this study, in an effort to discover the impact of bagging treatments on the occurrence of peel browning spots and fruit quality, fruits were covered by single-layer, two-layer, or triple-layer paper bags six weeks after reaching full bloom. The results showed that the bagged fruits were characterized by smooth surfaces and reduced lenticels compared with the unbagged ones. The unbagg

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21

Pangaribowo, Dian Agung, Fathunnisa Fathunnisa, Ari Satia Nugraha, Ayik Rosita Puspaningtyas, and Indah Purnama Sary. "Structure Modification of Cinnamic Acid to (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one and Antioxidant Activity Test by DPPH Method." Borneo Journal of Pharmacy 7, no. 3 (2024): 254–63. http://dx.doi.org/10.33084/bjop.v7i3.6163.

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Antioxidants can protect cells from free radical damage by stabilizing them. One of the compounds that has antioxidant activity is cinnamic acid. Cinnamic acid and its derivatives have several activities: antibacterial, anticancer, and antioxidant. However, the ability of cinnamic acid to capture free radicals is still relatively low. One of the efforts that can be made to increase the antioxidant activity of cinnamic acid is to modify its structure. Structure modification is an effort to improve the pharmacological activity of a compound through chemical synthesis reactions. The cinnamic acid

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L. Dangeubun, Jane, AM Serang, Petrus Letsoin, and Maryani Maryani. "Fitokimia, Uji Antibakteri dan Uji Toksisitas dan Dari Ekstrak Daun Kayu Manis (Cinnamomum burmannii) Terhadap Tingkat Kematian Larva Artemia Salina Leach." Jurnal Akuakultur Sungai dan Danau 9, no. 1 (2024): 21. http://dx.doi.org/10.33087/akuakultur.v9i1.194.

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. Cinnamon leaves have properties as lowering blood sugar levels, inhibiting bacterial growth. Cinnamon traditional medicine contains the largest component of chemical substances, namely cinnamic alcohol, coumarin, cinnamic acid, sinamaldehyde, anthocinin and essential oils with sugar, protein, simple fat, pectin and others. Furthermore, it is said that cinnamon has antimicrobial, antifungal, antiviral, antioxidant, antitumor, blood pressure lowering, cholesterol and has low fat compounds. The dominant polyphenolic compound in cinnamon leaves is from the aldehyde group, which has insulin-like

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Hu, Lei, Xuan Zhang, Huihui Ni, Fangyu Yuan, and Shuiming Zhang. "Identification and Functional Analysis of CAD Gene Family in Pomegranate (Punica granatum)." Genes 14, no. 1 (2022): 26. http://dx.doi.org/10.3390/genes14010026.

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[Objective] Cinnamyl alcohol dehydrogenase (CAD) is a key enzyme in lignin biosynthesis. The aim of this study was to identify CAD gene family members in pomegranate and its expression correlation with seed hardness. [Methods] Based on the reported CAD sequence of Arabidopsis, the CAD gene family of pomegranate was identified by homologous comparison, and then phylogenetic, molecular characterization, and expression profile analysis were performed. [Results] Pomegranate CAD gene family has 25 members, distributed on seven chromosomes of pomegranate. All pomegranate CAD proteins have similar ph

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Ashour, Ahmed, Asmaa E. Sherif, Selwan M. El-Sayed та ін. "Tetraenone A: A New β-Ionone Derivative from Tetraena aegyptia". Metabolites 13, № 12 (2023): 1202. http://dx.doi.org/10.3390/metabo13121202.

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In this study, the chemical investigation of Tetraena aegyptia (Zygophyllaceae) led to the identification of a new megastigmene derivative, tetraenone A ((2S, 5R, 6R, 7E)-2-hydroxy-5,6-dihydro-β-ionone) (1), along with (3S, 5R, 6S, 7E)-3-hydroxy-5,6-epoxy-5,6-dihydro-β-ionone- (2), 3,4-dihydroxy-cinnamyl alcohol-4-glucoside (3), 3β,19α-dihydroxy-ursan-28-oic acid (4), quinovic acid (5), p-coumaric acid (6), and ferulic acid (7), for the first time. The chemical structures of 1–7 were confirmed by analysis of their 1D and 2D NMR and HRESIMS spectra and by their comparison with the relevant lite

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Ubaid, Moayad Mijbil, Shatha Hussein Kadhim, and Zahraa Abed Al-kareem. "Protective effect of cinnamon oil against ciprofloxacin toxicity on liver and kidney of male Wistar rats." Journal of Applied and Natural Science 14, no. 4 (2022): 1430–34. http://dx.doi.org/10.31018/jans.v14i4.3823.

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Cinnamon zeylanicum is one of many herbal medications. This herb contains different materials like, cumarin, cinnamaldehyde and cinnamic acid. The plant plays a role as antiallergic, antiviral, antimicrobial, anti-inflammatory and antioxidant and other health conditions. This study focused on the therapeutic effect of cinnamon oil on hepatorenal toxicity induced by ciprofloxacin in male rats. Forty rats were housed in the animal house of the College of Pharmacy, University of Kerbala, Karbala city, Iraq. The animals were separated into four groups: Group 1. Control group (not taken drug nor ci

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Аксенова (Aksenova), Юлия (Yuliya) Борисовна (Borisovna), Ирина (Irina) Викторовна (Viktorovna) Лапко (Lapko), Ольга (Ol'ga) Витальевна (Vital'evna) Кузнецова (Kuznetsova), et al. "COMPARATIVE ANALYSIS OF QUALITATIVE AND QUANTITATIVE COMPOSITION OF DIFFERENT KINDS OF CINNAMON BARK (CINNAMOMUM)." chemistry of plant raw material, no. 3 (March 27, 2018): 159–67. http://dx.doi.org/10.14258/jcprm.2018033805.

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The qualitative and quantitative composition of four types of cinnamon bark (Cinnamomum) was studied by gas chromatography with mass spectrometric detection.Found in these samples were 72 compounds of various classes, including terpenes, aldehydes, alcohols, organic acids, coumarins, esters, catechins, vitamins, sterols, and sugars. As a result of the comparative analysis, the specific compounds were found that are characteristic for Cinnamomum zeylanicum (3-tuyen, 4 (10) -tuyen, eugenol, (-)-α-curcumen, linolenic acid and for a group of Cinnamomum burmannii, Cinnamomum loureiroi and Cinnamomu

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Liu, Yiwei, Ziwuyun Weng, Yuanyuan Liu, et al. "Identification of the Cinnamyl Alcohol Dehydrogenase Gene Family in Brassica U-Triangle Species and Its Potential Roles in Response to Abiotic Stress and Regulation of Seed Coat Color in Brassica napus L." Plants 14, no. 8 (2025): 1184. https://doi.org/10.3390/plants14081184.

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Cinnamyl alcohol dehydrogenase (CAD) is essential for lignin precursor synthesis and responses to various abiotic stresses in plants. However, the functions of CAD in Brassica species, especially in Brassica napus, remain poorly characterized. In the present study, we identified a total of 90 CAD genes across the Brassica U-triangle species, including B. rapa, B. nigra, B. oleracea, B. juncea, B. napus, and B. carinata. Comprehensive analyses of phylogenetic relationships, sequence identity, conserved motifs, gene structure, chromosomal distribution, collinearity, and cis-acting elements were

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Kubatka, Peter, Martin Kello, Karol Kajo, et al. "Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses." Molecules 25, no. 6 (2020): 1399. http://dx.doi.org/10.3390/molecules25061399.

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Comprehensive oncology research suggests an important role of phytochemicals or whole plant foods in the modulation of signaling pathways associated with anticancer action. The goal of this study is to assess the anticancer activities of Cinnamomum zeylanicum L. using rat, mouse, and cell line breast carcinoma models. C. zeylanicum (as bark powder) was administered in the diet at two concentrations of 0.1% (w/w) and 1% (w/w) during the whole experiment in chemically induced rat mammary carcinomas and a syngeneic 4T1 mouse model. After autopsy, histopathological and molecular evaluations of mam

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Han, Ye, Ruirui Yang, Xuejiao Zhang, et al. "Brassinosteroid Accelerates Wound Healing of Potato Tubers by Activation of Reactive Oxygen Metabolism and Phenylpropanoid Metabolism." Foods 11, no. 7 (2022): 906. http://dx.doi.org/10.3390/foods11070906.

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Wound healing could effectively reduce the decay rate of potato tubers after harvest, but it took a long time to form typical and complete healing structures. Brassinosteroid (BR), as a sterol hormone, is important for enhancing plant resistance to abiotic and biotic stresses. However, it has not been reported that if BR affects wound healing of potato tubers. In the present study, we observed that BR played a positive role in the accumulation of lignin and suberin polyphenolic (SPP) at the wounds, and effectively reduced the weight loss and disease index of potato tubers (cv. Atlantic) during

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Chochkova, Maya G., Petranka P. Petrova, Boyka M. Stoykova та ін. "Structure-Activity Relationships ofN-Cinnamoyl and Hydroxycinnamoyl Amides onα-Glucosidase Inhibition". Journal of Chemistry 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/6080129.

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Currently, there is an increasing interest towardsα-glucosidase inhibition of various diseases including diabetes mellitus type 2, cancer, HIV, and B- and C-type viral hepatitis. Cinnamic acid derivatives have been shown to be potentially valuable as a new group ofα-glucosidase inhibitors. Therefore, herein, theα-glucosidase inhibitory activity oftrans-N-cinnamoyl and hydroxycinnamoyl amides was studied in vitro. Results revealed that the tested hydroxycinnamoyl amides (1–16) inhibiteda-glucosidase with IC50s ranging between 0.76 and 355.1 μg/ml. Compounds1,2,5,6,9,14, and15showed significant

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do Nascimento, Mayara S. S., Vitória R. F. Câmara, Juliana S. da Costa, et al. "Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates." Medicinal Chemistry 16, no. 6 (2020): 774–83. http://dx.doi.org/10.2174/1573406415666190627103013.

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Background:: Although several research efforts have been made worldwide to discover novel drug candidates for the treatment of Chagas disease, the nitroimidazole drug benznidazol remains the only therapeutic alternative in the control of this disease. However, this drug presents reduced efficacy in the chronic form of the disease and limited safety after long periods of administration, making it necessary to search for new, more potent and safe prototypes. Objective:: We described herein the synthesis and the trypanocidalaction of new functionalized carbohydrazonamides (2-10) against trypomast

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Hasegawa, Toshio, Momohiro Hashimoto, Takashi Fujihara, and Hideo Yamada. "Aroma Profile of Galangal Composed of Cinnamic Acid Derivatives and Their Structure-Odor Relationships." Natural Product Communications 11, no. 10 (2016): 1934578X1601101. http://dx.doi.org/10.1177/1934578x1601101012.

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Cinnamic acid derivatives are important odorants due to their characteristic scent. Some fragrance materials, such as cinnamon bark, matsutake mushrooms, and Kaempferia galanga L. rhizome (galangal), contain several cinnamic acid derivatives as important odor constituents. The main odor constituent of galangal is ( E)-ethyl 4-methoxycinnamate, but the odor of this compound is different from that of galangal. We investigated the aroma profile of galangal using our previously described method that considers the intermolecular interactions of the odorant compounds with their receptors. Odorant co

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Ruwizhi, Ngonidzashe, and Blessing Atim Aderibigbe. "Cinnamic Acid Derivatives and Their Biological Efficacy." International Journal of Molecular Sciences 21, no. 16 (2020): 5712. http://dx.doi.org/10.3390/ijms21165712.

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The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes and neurological disorders, among many, has been reported. Cinnamic acid is obtained from cinnamon bark. Its structure is composed of a benzene ring, an alkene double bond and an acrylic acid functional group making it possible to modify the aforementioned functionalities with a variety of compounds resulting in bioactive agents with enhanced efficacy. The nature of the substituents incorporated into cinnamic acid has been found to play a huge role in either enhancing or decreasing the biological ef

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Rybakova, A., D. Kim, and N. Stolpovskaya. "Synthesis and structure of new 4-amino-1,3,5-triazine-2-thione S-derivatives and their study by 1H, 13C NMR and chromatography-mass spectrometry." Bulletin of the South Ural State University series "Chemistry" 16, no. 1 (2024): 93–107. http://dx.doi.org/10.14529/chem240107.

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4-Amino-1,3,5-triazine-2-thione 1 interacts with allyl bromide, 2-methyl-3-chloro-1-propene, 2,3-dibromopropene-1, prenyl bromide in DMFA/K2CO3 and with cinnamyl chloride, butenyl bromide in DMFA/NaOH to form 4-allylsulfanyl- 2, 4-(2-methylpropene-2-yl)sulfanyl- 3, 4-(2-bromopropene-2-yl)sulfanyl- 4, 4-(2-methylbutene-2-yl)sulfanyl- 5, 4-cinnamylsulfanyl- 6 and 4-(butene-1-yl)sulfanyl-1,3,5-triazine-2-amines 7, respectively. The structure of compounds 2–7 was studied by 1H NMR, as well as of compounds 5 and 7, in their case including 13C NMR; allyl sulfide 2, prenyl sulfide 5 and butenyl sulfi

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NAKAGAWA-IZUMI, Akiko, and Ken-ichi KURODA. "Analysis of cinnamyl alcohol- and cinnamyl aldehyde end groups in lignin by trimethylsilylation/pyrolysis-gas chromatography." BUNSEKI KAGAKU 52, no. 12 (2003): 1159–66. http://dx.doi.org/10.2116/bunsekikagaku.52.1159.

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Kaitner, Branko, and Vladimir Stilinović. "p-Cresyl cinnamate." Acta Crystallographica Section E Structure Reports Online 63, no. 11 (2007): o4347. http://dx.doi.org/10.1107/s1600536807050064.

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In the crystal structure of the title compound [4-methylphenyl (E)-3-phenylpropenoate], C16H14O2, the benzene ring of the cinnamoyl group is slightly distorted due to conjugation with the double bond. The mean plane of the cinnamoyl group forms a dihedral angle of 61.1 (1)° with the plane of the cresyl group.

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Morikawa, Kouhei, Ken Tanaka, Feng Li, et al. "Analysis of MS/MS Fragmentation of Taxoids." Natural Product Communications 5, no. 10 (2010): 1934578X1000501. http://dx.doi.org/10.1177/1934578x1000501007.

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The fragmentation pathways of seven types of taxoids were investigated by using a LC-MS/MS method, namely: (1) neutral taxoids with a C-4(20) double bond; (2) taxoids with a C-4(20) double bond and oxygenation at C-14; (3) 5-cinnamoyl taxoids with a C-4(20) double bond; (4) a basic taxoid with a C-4(20) double bond; (5) a taxoid with a C-4(20) epoxide; (6) taxoids with an oxetane ring; and (7) taxoids with an oxetane ring and a phenylisoserine C-13 side chain. Depending on the class of core structure and the substitution pattern, each taxoid gave either the molecular adduct ion [M+NH4]+ or [M+

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Indriyanti, Erwin, and Masitoh Suryaning Prahasiwi. "Synthesis of Cinnamic Acid Based on Perkin Reaction Using Sonochemical Method and Its Potential as Photoprotective Agent." JKPK (Jurnal Kimia dan Pendidikan Kimia) 5, no. 1 (2020): 54. http://dx.doi.org/10.20961/jkpk.v5i1.38136.

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<p>Cinnamic acid plays a vital role in the synthesis of other important compounds and as a precursor for the synthesis of commercial cinnamon esters used in perfumery, cosmetics, and pharmaceutical industries. The aim of this research is to synthesize cinnamic acid using sonochemical methods. Cinnamic acid was synthesized using Perkin reaction by reacting 0.05 mole of benzaldehyde with 0.073 mole of acetic acid anhydride and 0.03 mole of sodium acetate as a catalyst in the Erlenmeyer flask and then the mixture was put in a sonicator for 60 minutes at 70 <sup>o</sup>C. The syn

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Balaji, R., D. Grande, and S. Nanjundan. "Studies on photocrosslinkable polymers having bromo-substituted pendant cinnamoyl group." Reactive and Functional Polymers 56, no. 1 (2003): 45–57. http://dx.doi.org/10.1016/s1381-5148(03)00031-2.

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Kim, Jinyool, Sanghee Kim, Kyusoon Park, and Taemin Kim. "P-67: Applications of New Photoalignment Materials Containing Cinnamoyl Group." SID Symposium Digest of Technical Papers 32, no. 1 (2001): 806. http://dx.doi.org/10.1889/1.1831988.

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Lackus, Nathalie D., Axel Schmidt, Jonathan Gershenzon та Tobias G. Köllner. "A peroxisomal β-oxidative pathway contributes to the formation of C6–C1 aromatic volatiles in poplar". Plant Physiology 186, № 2 (2021): 891–909. http://dx.doi.org/10.1093/plphys/kiab111.

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Abstract Benzenoids (C6–C1 aromatic compounds) play important roles in plant defense and are often produced upon herbivory. Black cottonwood (Populus trichocarpa) produces a variety of volatile and nonvolatile benzenoids involved in various defense responses. However, their biosynthesis in poplar is mainly unresolved. We showed feeding of the poplar leaf beetle (Chrysomela populi) on P. trichocarpa leaves led to increased emission of the benzenoid volatiles benzaldehyde, benzylalcohol, and benzyl benzoate. The accumulation of salicinoids, a group of nonvolatile phenolic defense glycosides comp

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Imani, Ghazal, Alireza khalilian, Dara Dastan, Behzad Imani, and Maryam Mehrpoya. "Effects of cinnamon extract on complications of treatment and eradication of Helicobacter pylori in infected people." Journal of Herbmed Pharmacology 9, no. 1 (2020): 55–60. http://dx.doi.org/10.15171/jhp.2020.08.

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Introduction: Treatment of Helicobacter pylori has various side effects like antibiotic resistance. The purpose of this study was to evaluate the effects of cinnamon extract on complications of treatment and eradication of H. pylori in infected people. Methods: In this randomized clinical trial, a total of 98 eligible healthy and H. pylori-infected patients approved by esophageal endoscopy were selected. The cinnamon group received multi-drug treatment including clarithromycin, amoxicillin and pantoprazole as well as a cinnamon extract capsule. The control group received multi-drug treatment a

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AL-Saffar, Haidar, and Munaf H. Zalzala. "The Possible Protective Effect of Cinnamic Acid on Ovalbumin-Induced Asthma in Mice." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 32, no. 1 (2023): 133–38. http://dx.doi.org/10.31351/vol32iss1pp133-138.

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Asthma is a chronic respiratory disorder in which immunological and structural cells play a role. The limits of conventional medicines necessitate the development of innovative therapeutic techniques for asthma. In the present study, we investigated the possible protective effect of cinnamic acid (CA) on ovalbumin-induced asthma in a mouse model. Sixty albino male mice BALB/c type weighing (20-30) grams were chosen at random and divided into five groups each one contains 12 animal: Group I: PBS/liquid paraffin control. Group II: asthma model group. Group III: cinnamic acid control group; mice

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Agustia, Dilma'aarij, Sutan Sahala Muda Marpaung, and Dita Anggriani Lubis. "Effects of cinnamon extract on blood sugar levels of type 2 diabetes mellitus patients: Randomized Controlled Trial (RCT)." AcTion: Aceh Nutrition Journal 10, no. 2 (2025): 237. https://doi.org/10.30867/action.v10i2.2261.

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Cinnamon is an herbal remedy proven to lower blood sugar levels in patients with type 2 diabetes mellitus (DM). Cinnamon contains coumarin, which reduces the blood sugar levels. This study aimed to determine whether administration of a higher dose of cinnamon could lower blood sugar levels in individuals with type 2 diabetes mellitus. Methods: This study employed a randomized controlled trial (RCT) design and was conducted at the Medan Denai Health Center from November to December 2023. Participants were randomly selected and divided into two groups: the intervention group, which received cinn

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Kuroda, Ken-ichi. "Analytical pyrolysis products derived from cinnamyl alcohol-end groups in lignins." Journal of Analytical and Applied Pyrolysis 53, no. 2 (2000): 123–34. http://dx.doi.org/10.1016/s0165-2370(99)00067-4.

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Yudrika, Filza, Sri Rahayu, and Supriyadi Supriyadi. "PEMBERIAN KOMBINASI COKELAT KAYU MANIS EFEKTIF UNTUK MENURUNKAN NYERI DISMENOREA PRIMER." Media Penelitian dan Pengembangan Kesehatan 35, no. 1 (2025): 1–10. https://doi.org/10.34011/jmp2k.v35i1.2281.

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Menstruation is a monthly occurrence during the reproductive period which sometimes causes discomfort called dysmenorrhea. Dark chocolate and cinnamon are known to have good analgesic properties. Many efforts have been made to provide dark chocolate and extra cinnamon to reduce dysmenorrhea. However, the combination of the two has never been done, researchers have developed an innovative cinnamon chocolate product to reduce dysmenorrhea in adolescent girls. Objective to determine the effect of cinnamon chocolate, prostaglandin levels and the degree of menstrual pain in adolescent girls. True-e

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Kassaee, Seyed Mehrdad, Mohammad Taghi Goodarzi, and Ebrahim Abbasi Oshaghi. "Renoprotective Effects of Trigonella foenum and Cinnamon on Type 2 Diabetic Rats." Avicenna Journal of Medical Biochemistry 5, no. 1 (2017): 17–21. http://dx.doi.org/10.15171/ajmb.2017.03.

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Background: Herbal medicine is used in all parts of the world mainly for prevention and treatment of various disorders due to better cultural suitability, lower cost and less side effects. Objectives: The aim of this study was to determine the hypoglycemic and kidney-protective effects of the aqueous extract of Trigonella foenum and Cinnamon on diabetic rats. Methods: In this experimental study, rats were randomly divided into 6 groups as follows: Group 1: control group in which animals received chow diet, group 2: diabetic rats, group 3: diabetic rat + 2% T. foenum extract (w/w), group 4: dia

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Cobalt, Maya. "The effect of a warm compress of cinnamon on reducing pain in sufferers of arthritis gout." Jurnal Manajemen Asuhan Keperawatan 5, no. 1 (2021): 40–47. http://dx.doi.org/10.33655/mak.v5i1.111.

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Background: One of the disorders experienced by gout arthritis sufferers is pain in the joints. Joint pain in patients with gouty arthritis occurs due to deposits of monosodiumuric crystals that accumulate in the joints as a result of high levels of gout arthritis in the blood. One of the interventions that can be given to reduce the pain scale in sufferers of gouty arthritis is the administration of warm cinnamon compresses. The essential oil in cinnamon bark contains eugenol, where eugenol has a very hot and spicy taste so it can open the skin's pores. So that pain can be reduced with the wa

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Nishikubo, Tadatomi, Atsushi Kameyama, Nobuyuki Hayashi, and Riou Nakagome. "Synthesis of a new photoreactive polyester by addition reaction of bisepoxide with f-truxiloyl chloride and chemical modification of this polymer." High Performance Polymers 7, no. 3 (1995): 245–54. http://dx.doi.org/10.1088/0954-0083/7/3/001.

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A new reactive polyester (P-I) containing a cyclobutane ring in the main chain and a pendant chloromethyl group in the side chain was synthesized successfully by the addition reaction of diglycidyl ether of bisphenol A (DGEBA) with fi-truxiloyl chloride (TC). The addition reaction of DGEBA with TC proceeded smoothly to give P-1 with a relatively high molecular weight using quaternary onium salts or a crown ether complex as catalysts at 90-C for 15 h. However, the reaction did not occur without a catalyst. Substitution reactions of the obtained P-I with (4-dimethy Iamino)cinnamic acid (MACA), [

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Farahpour, MR, and M. Habibi. " Evaluation of the wound healing activity of an ethanolic extract of Ceylon cinnamon in mice." Veterinární Medicína 57, No. 1 (2012): 53–57. http://dx.doi.org/10.17221/4972-vetmed.

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&nbsp;The present study was conducted to verify the effect of Ceylon cinnamon on experimentally induced excision wounds in rats. Thirty-two rats were divided into four groups of eight rats each. Group A received a placebo containing 1.5% of cinnamon and Group B a placebo containing 3%. Group C, as the control group, didn&rsquo;t receive any treatment and finally Group D received a blank placebo as the reference standard group. Wound healing was monitored on Days 3, 6, 9 and 14 and histological evaluation was carried out on the samples. The results show that cinnamon extract served to a

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